{"drug1": "trioxsalen", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "trioxsalen may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "5-Aminolevulinic acid", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "5-Aminolevulinic acid may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "TITANIUM DIOXIDE", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "TITANIUM DIOXIDE may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "tiaprofenic acid may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "Cyamemazine", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "Cyamemazine may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "TEMOPORFIN", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "TEMOPORFIN may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "methoxsalen may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "Hexaminolevulinate", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "Hexaminolevulinate may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "BENZOPHENONE", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "BENZOPHENONE may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "riboflavin", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "riboflavin may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "VERTEPORFIN", "interaction_type": 1, "interaction_text": "carprofen may increase the photosensitizing activities of VERTEPORFIN.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "methscopolamine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of methscopolamine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "hyoscyamine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of hyoscyamine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "pirenzepine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "TRIMETHAPHAN may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Pentolinium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Pentolinium.", "severity": 2}
{"drug1": "mequitazine", "drug2": "procarbazine", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of procarbazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Methylscopolamine bromide", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Methylscopolamine bromide.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Atracurium besylate", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Atracurium besylate.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "biperiden", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of biperiden.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "ipratropium", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of ipratropium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "pirenzepine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of pirenzepine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Tiotropium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Tiotropium.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "AMPHETAMINE", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Fesoterodine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Fesoterodine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Desloratadine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Desloratadine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "oxyphenonium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of oxyphenonium.", "severity": 2}
{"drug1": "doxylamine", "drug2": "selegiline", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of selegiline.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "pirenzepine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of pirenzepine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "ANISOTROPINE METHYLBROMIDE may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Vecuronium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Vecuronium.", "severity": 2}
{"drug1": "clemastine", "drug2": "isocarboxazid", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of isocarboxazid.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Pentolinium", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Pentolinium.", "severity": 2}
{"drug1": "doxylamine", "drug2": "procarbazine", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of procarbazine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "procyclidine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of procyclidine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "procyclidine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "tolterodine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of tolterodine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "mecamylamine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Pentolinium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Pentolinium.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ATROPINE", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of ATROPINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Butylscopolamine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Butylscopolamine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "isocarboxazid", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of isocarboxazid.", "severity": 2}
{"drug1": "propantheline", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "propantheline may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Atracurium besylate", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Atracurium besylate.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "propantheline", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of propantheline.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "TRIMETHAPHAN", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "pirenzepine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of pirenzepine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "isocarboxazid", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of isocarboxazid.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "scopolamine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of scopolamine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "doxylamine", "drug2": "AMPHETAMINE", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Pirlindole", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of Pirlindole.", "severity": 2}
{"drug1": "sulpiride", "drug2": "UMECLIDINIUM", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of UMECLIDINIUM.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Phenelzine", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of Phenelzine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "tubocurarine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of tubocurarine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "selegiline", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of selegiline.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "ipratropium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of ipratropium.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Pentolinium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Aclidinium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Aclidinium.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "moclobemide", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of moclobemide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "tubocurarine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of tubocurarine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "procyclidine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of procyclidine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "rasagiline", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of rasagiline.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Trospium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Trospium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Atracurium besylate", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Atracurium besylate.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ipratropium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of ipratropium.", "severity": 2}
{"drug1": "clemastine", "drug2": "furazolidone", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of furazolidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "quinidine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of quinidine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "methscopolamine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Propiverine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Propiverine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "quinidine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of quinidine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "TRIMETHAPHAN", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Methylscopolamine bromide", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Methylscopolamine bromide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "mecamylamine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of mecamylamine.", "severity": 2}
{"drug1": "clemastine", "drug2": "Pirlindole", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of Pirlindole.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Propiverine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Propiverine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "methscopolamine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of methscopolamine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "hyoscyamine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of hyoscyamine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "oxyphenonium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Fesoterodine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Fesoterodine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "propantheline", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of propantheline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "trihexyphenidyl", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of trihexyphenidyl.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "hyoscyamine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "doxylamine", "drug2": "Pirlindole", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of Pirlindole.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "tranylcypromine", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of tranylcypromine.", "severity": 2}
{"drug1": "Metixene", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Metixene may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "ATROPINE", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of ATROPINE.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "oxybutynin", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of oxybutynin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "oxyphenonium", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of oxyphenonium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Glycopyrronium", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Glycopyrronium.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Trospium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Trospium.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "furazolidone", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of furazolidone.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "tolterodine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of tolterodine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "methylene blue", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of methylene blue.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "tolterodine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of tolterodine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "moclobemide", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of moclobemide.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Trospium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Trospium.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Fesoterodine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Fesoterodine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ipratropium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of ipratropium.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "trihexyphenidyl", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of trihexyphenidyl.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "quinidine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of quinidine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "moclobemide", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of moclobemide.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "amantadine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of amantadine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Propiverine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "procyclidine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of procyclidine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "procarbazine", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of procarbazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Desloratadine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Desloratadine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "PIPECURONIUM", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Vecuronium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Vecuronium.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "mecamylamine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of mecamylamine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "trihexyphenidyl may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ethopropazine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of ethopropazine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "PIPECURONIUM", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "propantheline", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of propantheline.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Vecuronium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ATROPINE", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of ATROPINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "tropicamide", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of tropicamide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Pentolinium", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Pentolinium.", "severity": 2}
{"drug1": "doxylamine", "drug2": "Toloxatone", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of Toloxatone.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "tranylcypromine", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of tranylcypromine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "quinidine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of quinidine.", "severity": 2}
{"drug1": "clemastine", "drug2": "moclobemide", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of moclobemide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Trospium", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Trospium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Butylscopolamine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Butylscopolamine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "hyoscyamine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of hyoscyamine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "methscopolamine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of methscopolamine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Glycopyrronium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Glycopyrronium.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "PIPECURONIUM may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "oxyphenonium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of oxyphenonium.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "procarbazine", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of procarbazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "PIPECURONIUM", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ipratropium", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of ipratropium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Vecuronium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Vecuronium.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "scopolamine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of scopolamine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "AMPHETAMINE", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Trospium", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Trospium.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "orphenadrine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of orphenadrine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "tranylcypromine", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of tranylcypromine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "orphenadrine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "doxylamine", "drug2": "furazolidone", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of furazolidone.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "pirenzepine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of pirenzepine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "oxyphenonium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of oxyphenonium.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Desloratadine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Desloratadine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "ipratropium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "rasagiline", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of rasagiline.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "tolterodine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of tolterodine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "pancuronium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of pancuronium.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "hyoscyamine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of hyoscyamine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "propantheline", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of propantheline.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ethopropazine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of ethopropazine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "moclobemide", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of moclobemide.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Methylscopolamine bromide", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Methylscopolamine bromide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "oxyphenonium", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of oxyphenonium.", "severity": 2}
{"drug1": "pancuronium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "pancuronium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "tubocurarine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of tubocurarine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Metixene", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Metixene.", "severity": 2}
{"drug1": "clemastine", "drug2": "procarbazine", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of procarbazine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "tubocurarine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of tubocurarine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "trihexyphenidyl", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of trihexyphenidyl.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Tiotropium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Tiotropium.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "pirenzepine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of pirenzepine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "mecamylamine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of mecamylamine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Methylscopolamine bromide", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Methylscopolamine bromide.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "cyclopentolate", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of cyclopentolate.", "severity": 2}
{"drug1": "tropicamide", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "tropicamide may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "biperiden", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of biperiden.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "TRIMETHAPHAN", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Propiverine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Propiverine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "TRIMETHAPHAN", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Atracurium besylate", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Atracurium besylate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "tropicamide", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of tropicamide.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "mecamylamine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of mecamylamine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "pargyline", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of pargyline.", "severity": 2}
{"drug1": "clemastine", "drug2": "rasagiline", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of rasagiline.", "severity": 2}
{"drug1": "tolterodine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "tolterodine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "benztropine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "benztropine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Metixene", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Metixene.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "orphenadrine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of orphenadrine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Propiverine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Propiverine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Fesoterodine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Fesoterodine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "isocarboxazid", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of isocarboxazid.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Butylscopolamine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "mequitazine", "drug2": "selegiline", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of selegiline.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "quinidine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of quinidine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "rasagiline", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of rasagiline.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Toloxatone", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of Toloxatone.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "cyclopentolate", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of cyclopentolate.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "methylene blue", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of methylene blue.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "procyclidine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of procyclidine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "trihexyphenidyl", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of trihexyphenidyl.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "dicyclomine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Pirlindole", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of Pirlindole.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "mecamylamine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of mecamylamine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "tubocurarine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of tubocurarine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Tiotropium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Tiotropium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "benztropine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of benztropine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "tropicamide", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of tropicamide.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "selegiline", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of selegiline.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "propantheline", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of propantheline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "isocarboxazid", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of isocarboxazid.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "pancuronium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of pancuronium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Pentolinium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Pentolinium.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "dicyclomine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of dicyclomine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "PIPECURONIUM", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Desloratadine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Desloratadine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "doxylamine", "drug2": "pargyline", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of pargyline.", "severity": 2}
{"drug1": "clemastine", "drug2": "AMPHETAMINE", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "rasagiline", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of rasagiline.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Pirlindole", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of Pirlindole.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Atracurium besylate may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "ethopropazine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Phenelzine", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of Phenelzine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Toloxatone", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of Toloxatone.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "cyclopentolate", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of cyclopentolate.", "severity": 2}
{"drug1": "mequitazine", "drug2": "AMPHETAMINE", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "methylene blue", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of methylene blue.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "oxybutynin", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of oxybutynin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Metixene", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Metixene.", "severity": 2}
{"drug1": "biperiden", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "biperiden may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "dicyclomine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of dicyclomine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "hyoscyamine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of hyoscyamine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "scopolamine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "biperiden", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of biperiden.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "cyclopentolate may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "clemastine", "drug2": "pargyline", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of pargyline.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "biperiden", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of biperiden.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "ethopropazine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of ethopropazine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Butylscopolamine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Butylscopolamine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Phenelzine", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of Phenelzine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "scopolamine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of scopolamine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "pancuronium", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of pancuronium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ATROPINE", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of ATROPINE.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "pargyline", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of pargyline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "biperiden", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of biperiden.", "severity": 2}
{"drug1": "sulpiride", "drug2": "methscopolamine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of methscopolamine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "tranylcypromine", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of tranylcypromine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "dicyclomine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of dicyclomine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "pargyline", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of pargyline.", "severity": 2}
{"drug1": "doxylamine", "drug2": "Phenelzine", "interaction_type": 2, "interaction_text": "doxylamine may increase the anticholinergic activities of Phenelzine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "benztropine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of benztropine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Glycopyrronium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Glycopyrronium.", "severity": 2}
{"drug1": "Trospium", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Trospium may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "tubocurarine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "mequitazine", "drug2": "furazolidone", "interaction_type": 2, "interaction_text": "mequitazine may increase the anticholinergic activities of furazolidone.", "severity": 2}
{"drug1": "clemastine", "drug2": "Phenelzine", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of Phenelzine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Butylscopolamine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Butylscopolamine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "orphenadrine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of orphenadrine.", "severity": 2}
{"drug1": "clemastine", "drug2": "tranylcypromine", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of tranylcypromine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "ATROPINE may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "procyclidine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of procyclidine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "scopolamine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of scopolamine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "trihexyphenidyl", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of trihexyphenidyl.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "benztropine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of benztropine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "TRIMETHAPHAN", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "orphenadrine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of orphenadrine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "furazolidone", "interaction_type": 2, "interaction_text": "CYPROHEPTADINE may increase the anticholinergic activities of furazolidone.", "severity": 2}
{"drug1": "quinidine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "quinidine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "tropicamide", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of tropicamide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Aclidinium", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Aclidinium.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "dicyclomine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of dicyclomine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Methylscopolamine bromide may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Metixene", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Metixene.", "severity": 2}
{"drug1": "sulpiride", "drug2": "cyclopentolate", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of cyclopentolate.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "oxybutynin may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Desloratadine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of Desloratadine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "oxybutynin", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of oxybutynin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "benztropine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of benztropine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Glycopyrronium", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Glycopyrronium.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Vecuronium", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Vecuronium.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ethopropazine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of ethopropazine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "methscopolamine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of methscopolamine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "benztropine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of benztropine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "tolterodine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of tolterodine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "dicyclomine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of dicyclomine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "cyclopentolate", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of cyclopentolate.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "pancuronium", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of pancuronium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "tropicamide", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of tropicamide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Propiverine", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Propiverine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "scopolamine", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of scopolamine.", "severity": 2}
{"drug1": "clemastine", "drug2": "Toloxatone", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of Toloxatone.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "oxybutynin", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of oxybutynin.", "severity": 2}
{"drug1": "clemastine", "drug2": "selegiline", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of selegiline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Atracurium besylate", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Atracurium besylate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Fesoterodine", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of Fesoterodine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Butylscopolamine", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Butylscopolamine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "ethopropazine", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of ethopropazine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Methylscopolamine bromide", "interaction_type": 2, "interaction_text": "UMECLIDINIUM may increase the anticholinergic activities of Methylscopolamine bromide.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "mianserin", "interaction_type": 2, "interaction_text": "Desloratadine may increase the anticholinergic activities of mianserin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Metixene", "interaction_type": 2, "interaction_text": "Glycopyrronium may increase the anticholinergic activities of Metixene.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "PIPECURONIUM", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Vecuronium", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of Vecuronium.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Toloxatone", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of Toloxatone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "oxybutynin", "interaction_type": 2, "interaction_text": "sulpiride may increase the anticholinergic activities of oxybutynin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "pancuronium", "interaction_type": 2, "interaction_text": "Tiotropium may increase the anticholinergic activities of pancuronium.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "methylene blue", "interaction_type": 2, "interaction_text": "Pizotifen may increase the anticholinergic activities of methylene blue.", "severity": 2}
{"drug1": "clemastine", "drug2": "methylene blue", "interaction_type": 2, "interaction_text": "clemastine may increase the anticholinergic activities of methylene blue.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "ATROPINE", "interaction_type": 2, "interaction_text": "Aclidinium may increase the anticholinergic activities of ATROPINE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Almasilate", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Almasilate", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Almasilate", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Trometamol", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Trometamol", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Almasilate", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Trometamol", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Trometamol", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Almasilate", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aluminium", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Aluminium", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Trometamol", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aluminium", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Aluminium", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "equilin", "interaction_type": 3, "interaction_text": "The bioavailability of equilin can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "alclometasone", "interaction_type": 3, "interaction_text": "The bioavailability of alclometasone can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "flunisolide", "interaction_type": 3, "interaction_text": "The bioavailability of flunisolide can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Aluminium", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Dehydroepiandrosterone", "interaction_type": 3, "interaction_text": "The bioavailability of Dehydroepiandrosterone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "methylprednisolone", "interaction_type": 3, "interaction_text": "The bioavailability of methylprednisolone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "RIMEXOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of RIMEXOLONE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "halcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of halcinonide can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "DEFLAZACORT", "interaction_type": 3, "interaction_text": "The bioavailability of DEFLAZACORT can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "difluprednate", "interaction_type": 3, "interaction_text": "The bioavailability of difluprednate can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "estrone", "interaction_type": 3, "interaction_text": "The bioavailability of estrone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOBETASOL PROPIONATE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "fludrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of fludrocortisone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "desoximetasone", "interaction_type": 3, "interaction_text": "The bioavailability of desoximetasone can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Aluminium", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Estrone sulfate", "interaction_type": 3, "interaction_text": "The bioavailability of Estrone sulfate can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "amcinonide", "interaction_type": 3, "interaction_text": "The bioavailability of amcinonide can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUTICASONE PROPIONATE can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "ampicillin", "drug2": "atenolol", "interaction_type": 3, "interaction_text": "The bioavailability of atenolol can be decreased when combined with ampicillin.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "triamcinolone", "interaction_type": 3, "interaction_text": "The bioavailability of triamcinolone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "DESONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of DESONIDE can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "PREDNICARBATE", "interaction_type": 3, "interaction_text": "The bioavailability of PREDNICARBATE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "prednisone", "interaction_type": 3, "interaction_text": "The bioavailability of prednisone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "hydrocortisone", "interaction_type": 3, "interaction_text": "The bioavailability of hydrocortisone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with Trometamol.", "severity": 2}
{"drug1": "Almasilate", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 3, "interaction_text": "The bioavailability of BECLOMETHASONE DIPROPIONATE can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Fluprednidene", "interaction_type": 3, "interaction_text": "The bioavailability of Fluprednidene can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "FLUOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCORTOLONE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Mometasone", "interaction_type": 3, "interaction_text": "The bioavailability of Mometasone can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "betamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of betamethasone can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Clobetasone", "interaction_type": 3, "interaction_text": "The bioavailability of Clobetasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Tixocortol", "interaction_type": 3, "interaction_text": "The bioavailability of Tixocortol can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "fluocinonide", "interaction_type": 3, "interaction_text": "The bioavailability of fluocinonide can be decreased when combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Ciclesonide", "interaction_type": 3, "interaction_text": "The bioavailability of Ciclesonide can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "CLOCORTOLONE", "interaction_type": 3, "interaction_text": "The bioavailability of CLOCORTOLONE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "dexamethasone", "interaction_type": 3, "interaction_text": "The bioavailability of dexamethasone can be decreased when combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "diflorasone", "interaction_type": 3, "interaction_text": "The bioavailability of diflorasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "budesonide", "interaction_type": 3, "interaction_text": "The bioavailability of budesonide can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Fluticasone furoate", "interaction_type": 3, "interaction_text": "The bioavailability of Fluticasone furoate can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "flumethasone", "interaction_type": 3, "interaction_text": "The bioavailability of flumethasone can be decreased when combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "formestane", "interaction_type": 3, "interaction_text": "The bioavailability of formestane can be decreased when combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "CORTISONE ACETATE", "interaction_type": 3, "interaction_text": "The bioavailability of CORTISONE ACETATE can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "paramethasone", "interaction_type": 3, "interaction_text": "The bioavailability of paramethasone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "loteprednol", "interaction_type": 3, "interaction_text": "The bioavailability of loteprednol can be decreased when combined with Aluminium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "medrysone", "interaction_type": 3, "interaction_text": "The bioavailability of medrysone can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 3, "interaction_text": "The bioavailability of FLUOCINOLONE ACETONIDE can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Halobetasol", "interaction_type": 3, "interaction_text": "The bioavailability of Halobetasol can be decreased when combined with Magaldrate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "flurandrenolide", "interaction_type": 3, "interaction_text": "The bioavailability of flurandrenolide can be decreased when combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nafcillin", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lapatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lapatinib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with primidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "Bosentan", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Bortezomib", "interaction_type": 4, "interaction_text": "The metabolism of Bortezomib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "5-Fluorouracil", "interaction_type": 4, "interaction_text": "The metabolism of 5-Fluorouracil can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "salicylic acid", "interaction_type": 4, "interaction_text": "The metabolism of salicylic acid can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "primidone", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "orphenadrine", "interaction_type": 4, "interaction_text": "The metabolism of orphenadrine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ritonavir", "interaction_type": 4, "interaction_text": "The metabolism of ritonavir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "indinavir", "interaction_type": 4, "interaction_text": "The metabolism of indinavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nelfinavir", "interaction_type": 4, "interaction_text": "The metabolism of nelfinavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "metronidazole", "interaction_type": 4, "interaction_text": "The metabolism of metronidazole can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mefloquine", "interaction_type": 4, "interaction_text": "The metabolism of mefloquine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "zolpidem", "interaction_type": 4, "interaction_text": "The metabolism of zolpidem can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "dienestrol", "interaction_type": 4, "interaction_text": "The metabolism of dienestrol can be increased when combined with griseofulvin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "amobarbital", "interaction_type": 4, "interaction_text": "The metabolism of amobarbital can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "primidone", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "primidone", "interaction_type": 4, "interaction_text": "The metabolism of primidone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nevirapine", "interaction_type": 4, "interaction_text": "The metabolism of nevirapine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "promethazine", "interaction_type": 4, "interaction_text": "The metabolism of promethazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "thiopental", "interaction_type": 4, "interaction_text": "The metabolism of thiopental can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nilutamide", "interaction_type": 4, "interaction_text": "The metabolism of nilutamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "salicylic acid", "interaction_type": 4, "interaction_text": "The metabolism of salicylic acid can be increased when combined with primidone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Elvitegravir", "interaction_type": 4, "interaction_text": "The metabolism of Elvitegravir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "nevirapine", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "isoflurane", "interaction_type": 4, "interaction_text": "The metabolism of isoflurane can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Fosamprenavir", "interaction_type": 4, "interaction_text": "The metabolism of Fosamprenavir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiopental", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with griseofulvin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "isoflurane", "interaction_type": 4, "interaction_text": "The metabolism of isoflurane can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "benztropine", "interaction_type": 4, "interaction_text": "The metabolism of benztropine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "salicylic acid", "interaction_type": 4, "interaction_text": "The metabolism of salicylic acid can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "RIFABUTIN", "interaction_type": 4, "interaction_text": "The metabolism of RIFABUTIN can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenytoin", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ETONOGESTREL", "interaction_type": 4, "interaction_text": "The metabolism of ETONOGESTREL can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "benztropine", "interaction_type": 4, "interaction_text": "The metabolism of benztropine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "RANOLAZINE", "interaction_type": 4, "interaction_text": "The metabolism of RANOLAZINE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with glutethimide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "benztropine", "interaction_type": 4, "interaction_text": "The metabolism of benztropine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with primidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with glutethimide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ritonavir", "interaction_type": 4, "interaction_text": "The metabolism of ritonavir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "METHOHEXITAL", "interaction_type": 4, "interaction_text": "The metabolism of METHOHEXITAL can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mianserin", "interaction_type": 4, "interaction_text": "The metabolism of mianserin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "colchicine", "interaction_type": 4, "interaction_text": "The metabolism of colchicine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nafcillin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 4, "interaction_text": "The metabolism of MAGNESIUM SULFATE can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "dyphylline", "interaction_type": 4, "interaction_text": "The metabolism of dyphylline can be increased when combined with L-thyroxine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "efavirenz", "interaction_type": 4, "interaction_text": "The metabolism of efavirenz can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "thiopental", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "oxiconazole", "interaction_type": 4, "interaction_text": "The metabolism of oxiconazole can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "phenobarbital", "interaction_type": 4, "interaction_text": "The metabolism of phenobarbital can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nafcillin", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "METHOHEXITAL", "interaction_type": 4, "interaction_text": "The metabolism of METHOHEXITAL can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Bosentan", "interaction_type": 4, "interaction_text": "The metabolism of Bosentan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pazopanib", "interaction_type": 4, "interaction_text": "The metabolism of Pazopanib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ritonavir", "interaction_type": 4, "interaction_text": "The metabolism of ritonavir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Cilastatin", "interaction_type": 4, "interaction_text": "The metabolism of Cilastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "trandolapril", "interaction_type": 4, "interaction_text": "The metabolism of trandolapril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "amoxicillin", "interaction_type": 4, "interaction_text": "The metabolism of amoxicillin can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "primidone", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "methadone", "interaction_type": 4, "interaction_text": "The metabolism of methadone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nevirapine", "interaction_type": 4, "interaction_text": "The metabolism of nevirapine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with thiopental.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "L-thyroxine", "interaction_type": 4, "interaction_text": "The metabolism of L-thyroxine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "meprobamate", "interaction_type": 4, "interaction_text": "The metabolism of meprobamate can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "meperidine", "interaction_type": 4, "interaction_text": "The metabolism of meperidine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "promethazine", "interaction_type": 4, "interaction_text": "The metabolism of promethazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rotigotine", "interaction_type": 4, "interaction_text": "The metabolism of Rotigotine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "indinavir", "interaction_type": 4, "interaction_text": "The metabolism of indinavir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nelfinavir", "interaction_type": 4, "interaction_text": "The metabolism of nelfinavir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Netupitant", "interaction_type": 4, "interaction_text": "The metabolism of Netupitant can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "phenytoin", "interaction_type": 4, "interaction_text": "The metabolism of phenytoin can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "promethazine", "interaction_type": 4, "interaction_text": "The metabolism of promethazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with thiopental.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "buprenorphine", "interaction_type": 4, "interaction_text": "The metabolism of buprenorphine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "famotidine", "interaction_type": 4, "interaction_text": "The metabolism of famotidine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vemurafenib", "interaction_type": 4, "interaction_text": "The metabolism of Vemurafenib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ketoconazole", "interaction_type": 4, "interaction_text": "The metabolism of ketoconazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with L-thyroxine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rifampicin", "interaction_type": 4, "interaction_text": "The metabolism of Rifampicin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "phenytoin", "interaction_type": 4, "interaction_text": "The metabolism of phenytoin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "SAQUINAVIR", "interaction_type": 4, "interaction_text": "The metabolism of SAQUINAVIR can be increased when combined with primidone.", "severity": 2}
{"drug1": "nafcillin", "drug2": "nimodipine", "interaction_type": 4, "interaction_text": "The metabolism of nimodipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fosamprenavir", "interaction_type": 4, "interaction_text": "The metabolism of Fosamprenavir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Delavirdine", "interaction_type": 4, "interaction_text": "The metabolism of Delavirdine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Temsirolimus", "interaction_type": 4, "interaction_text": "The metabolism of Temsirolimus can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with primidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with primidone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "azelastine", "interaction_type": 4, "interaction_text": "The metabolism of azelastine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Conivaptan", "interaction_type": 4, "interaction_text": "The metabolism of Conivaptan can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with thiopental.", "severity": 2}
{"drug1": "thiopental", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenytoin", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ketoconazole", "interaction_type": 4, "interaction_text": "The metabolism of ketoconazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "amobarbital", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amobarbital", "interaction_type": 4, "interaction_text": "The metabolism of amobarbital can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "primidone", "interaction_type": 4, "interaction_text": "The metabolism of primidone can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "RIFABUTIN", "interaction_type": 4, "interaction_text": "The metabolism of RIFABUTIN can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ketoconazole", "interaction_type": 4, "interaction_text": "The metabolism of ketoconazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nafcillin", "drug2": "dienestrol", "interaction_type": 4, "interaction_text": "The metabolism of dienestrol can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "L-thyroxine", "interaction_type": 4, "interaction_text": "The metabolism of L-thyroxine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mirtazapine", "interaction_type": 4, "interaction_text": "The metabolism of mirtazapine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "colchicine", "interaction_type": 4, "interaction_text": "The metabolism of colchicine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "norgestrel", "interaction_type": 4, "interaction_text": "The metabolism of norgestrel can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Rotigotine", "interaction_type": 4, "interaction_text": "The metabolism of Rotigotine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "teniposide", "interaction_type": 4, "interaction_text": "The metabolism of teniposide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Spirapril", "interaction_type": 4, "interaction_text": "The metabolism of Spirapril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "pentobarbital", "interaction_type": 4, "interaction_text": "The metabolism of pentobarbital can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rotigotine", "interaction_type": 4, "interaction_text": "The metabolism of Rotigotine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cilazapril", "interaction_type": 4, "interaction_text": "The metabolism of cilazapril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "METHSUXIMIDE", "interaction_type": 4, "interaction_text": "The metabolism of METHSUXIMIDE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Torasemide", "interaction_type": 4, "interaction_text": "The metabolism of Torasemide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ropinirole", "interaction_type": 4, "interaction_text": "The metabolism of ropinirole can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Rivaroxaban", "interaction_type": 4, "interaction_text": "The metabolism of Rivaroxaban can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with primidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "primidone", "interaction_type": 4, "interaction_text": "The metabolism of primidone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Aprepitant", "interaction_type": 4, "interaction_text": "The metabolism of Aprepitant can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Darunavir", "interaction_type": 4, "interaction_text": "The metabolism of Darunavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "amobarbital", "interaction_type": 4, "interaction_text": "The metabolism of amobarbital can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lopinavir", "interaction_type": 4, "interaction_text": "The metabolism of Lopinavir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ropinirole", "interaction_type": 4, "interaction_text": "The metabolism of ropinirole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "diethylstilbestrol", "interaction_type": 4, "interaction_text": "The metabolism of diethylstilbestrol can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "metoprolol", "interaction_type": 4, "interaction_text": "The metabolism of metoprolol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "glucosamine", "interaction_type": 4, "interaction_text": "The metabolism of glucosamine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "carisoprodol", "interaction_type": 4, "interaction_text": "The metabolism of carisoprodol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "secobarbital", "interaction_type": 4, "interaction_text": "The metabolism of secobarbital can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "colchicine", "interaction_type": 4, "interaction_text": "The metabolism of colchicine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ethanol", "interaction_type": 4, "interaction_text": "The metabolism of ethanol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ethanol", "interaction_type": 4, "interaction_text": "The metabolism of ethanol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nafcillin", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "disopyramide", "interaction_type": 4, "interaction_text": "The metabolism of disopyramide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "secobarbital", "interaction_type": 4, "interaction_text": "The metabolism of secobarbital can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "metoprolol", "interaction_type": 4, "interaction_text": "The metabolism of metoprolol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rifampicin", "interaction_type": 4, "interaction_text": "The metabolism of Rifampicin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "secobarbital", "interaction_type": 4, "interaction_text": "The metabolism of secobarbital can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pitavastatin", "interaction_type": 4, "interaction_text": "The metabolism of Pitavastatin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ranitidine", "interaction_type": 4, "interaction_text": "The metabolism of ranitidine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Erlotinib", "interaction_type": 4, "interaction_text": "The metabolism of Erlotinib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "efavirenz", "interaction_type": 4, "interaction_text": "The metabolism of efavirenz can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "felbamate", "interaction_type": 4, "interaction_text": "The metabolism of felbamate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "5-Fluorouracil", "interaction_type": 4, "interaction_text": "The metabolism of 5-Fluorouracil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "promethazine", "interaction_type": 4, "interaction_text": "The metabolism of promethazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Levonorgestrel", "interaction_type": 4, "interaction_text": "The metabolism of Levonorgestrel can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "meprobamate", "interaction_type": 4, "interaction_text": "The metabolism of meprobamate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ramipril", "interaction_type": 4, "interaction_text": "The metabolism of ramipril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Atomoxetine", "interaction_type": 4, "interaction_text": "The metabolism of Atomoxetine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "disopyramide", "interaction_type": 4, "interaction_text": "The metabolism of disopyramide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "disopyramide", "interaction_type": 4, "interaction_text": "The metabolism of disopyramide can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Enalaprilat", "interaction_type": 4, "interaction_text": "The metabolism of Enalaprilat can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "L-thyroxine", "interaction_type": 4, "interaction_text": "The metabolism of L-thyroxine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ethanol", "interaction_type": 4, "interaction_text": "The metabolism of ethanol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nafcillin", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "carisoprodol", "interaction_type": 4, "interaction_text": "The metabolism of carisoprodol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "mestranol", "interaction_type": 4, "interaction_text": "The metabolism of mestranol can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Medroxyprogesterone acetate", "interaction_type": 4, "interaction_text": "The metabolism of Medroxyprogesterone acetate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "METHOHEXITAL", "interaction_type": 4, "interaction_text": "The metabolism of METHOHEXITAL can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pitavastatin", "interaction_type": 4, "interaction_text": "The metabolism of Pitavastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vildagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Vildagliptin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "glutethimide", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with glutethimide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "RANOLAZINE", "interaction_type": 4, "interaction_text": "The metabolism of RANOLAZINE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Darunavir", "interaction_type": 4, "interaction_text": "The metabolism of Darunavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Bosentan", "interaction_type": 4, "interaction_text": "The metabolism of Bosentan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tacrolimus", "interaction_type": 4, "interaction_text": "The metabolism of tacrolimus can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Conivaptan", "interaction_type": 4, "interaction_text": "The metabolism of Conivaptan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "SIMEPREVIR", "interaction_type": 4, "interaction_text": "The metabolism of SIMEPREVIR can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "buprenorphine", "interaction_type": 4, "interaction_text": "The metabolism of buprenorphine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "RIFABUTIN", "interaction_type": 4, "interaction_text": "The metabolism of RIFABUTIN can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "SAQUINAVIR", "interaction_type": 4, "interaction_text": "The metabolism of SAQUINAVIR can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "Temsirolimus", "interaction_type": 4, "interaction_text": "The metabolism of Temsirolimus can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "METHSUXIMIDE", "interaction_type": 4, "interaction_text": "The metabolism of METHSUXIMIDE can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "primidone", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Apixaban", "interaction_type": 4, "interaction_text": "The metabolism of Apixaban can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "ritonavir", "interaction_type": 4, "interaction_text": "The metabolism of ritonavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with primidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "disopyramide", "interaction_type": 4, "interaction_text": "The metabolism of disopyramide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "carisoprodol", "interaction_type": 4, "interaction_text": "The metabolism of carisoprodol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "thiopental", "interaction_type": 4, "interaction_text": "The metabolism of thiopental can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "orphenadrine", "interaction_type": 4, "interaction_text": "The metabolism of orphenadrine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "phenobarbital", "interaction_type": 4, "interaction_text": "The metabolism of phenobarbital can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "VORTIOXETINE", "interaction_type": 4, "interaction_text": "The metabolism of VORTIOXETINE can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Imatinib", "interaction_type": 4, "interaction_text": "The metabolism of Imatinib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "famotidine", "interaction_type": 4, "interaction_text": "The metabolism of famotidine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "VALPROIC ACID", "interaction_type": 4, "interaction_text": "The metabolism of VALPROIC ACID can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pentobarbital", "interaction_type": 4, "interaction_text": "The metabolism of pentobarbital can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Quinine", "interaction_type": 4, "interaction_text": "The metabolism of Quinine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ketoconazole", "interaction_type": 4, "interaction_text": "The metabolism of ketoconazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ropinirole", "interaction_type": 4, "interaction_text": "The metabolism of ropinirole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Delavirdine", "interaction_type": 4, "interaction_text": "The metabolism of Delavirdine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Pitavastatin", "interaction_type": 4, "interaction_text": "The metabolism of Pitavastatin can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Rotigotine", "interaction_type": 4, "interaction_text": "The metabolism of Rotigotine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "benazepril", "interaction_type": 4, "interaction_text": "The metabolism of benazepril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "isoflurane", "interaction_type": 4, "interaction_text": "The metabolism of isoflurane can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "indinavir", "interaction_type": 4, "interaction_text": "The metabolism of indinavir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with griseofulvin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "meperidine", "interaction_type": 4, "interaction_text": "The metabolism of meperidine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "glucosamine", "interaction_type": 4, "interaction_text": "The metabolism of glucosamine can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "GUANFACINE", "interaction_type": 4, "interaction_text": "The metabolism of GUANFACINE can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "phenytoin", "interaction_type": 4, "interaction_text": "The metabolism of phenytoin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "METHSUXIMIDE", "interaction_type": 4, "interaction_text": "The metabolism of METHSUXIMIDE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ranitidine", "interaction_type": 4, "interaction_text": "The metabolism of ranitidine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "isoflurane", "interaction_type": 4, "interaction_text": "The metabolism of isoflurane can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Delavirdine", "interaction_type": 4, "interaction_text": "The metabolism of Delavirdine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Atomoxetine", "interaction_type": 4, "interaction_text": "The metabolism of Atomoxetine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "phenytoin", "interaction_type": 4, "interaction_text": "The metabolism of phenytoin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nilutamide", "interaction_type": 4, "interaction_text": "The metabolism of nilutamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nilutamide", "interaction_type": 4, "interaction_text": "The metabolism of nilutamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "SAQUINAVIR", "interaction_type": 4, "interaction_text": "The metabolism of SAQUINAVIR can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "5-Fluorouracil", "interaction_type": 4, "interaction_text": "The metabolism of 5-Fluorouracil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "isoflurane", "interaction_type": 4, "interaction_text": "The metabolism of isoflurane can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ranitidine", "interaction_type": 4, "interaction_text": "The metabolism of ranitidine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "timolol", "interaction_type": 4, "interaction_text": "The metabolism of timolol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenytoin", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nafcillin", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "orphenadrine", "interaction_type": 4, "interaction_text": "The metabolism of orphenadrine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "mianserin", "interaction_type": 4, "interaction_text": "The metabolism of mianserin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tacrolimus", "interaction_type": 4, "interaction_text": "The metabolism of tacrolimus can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "felbamate", "interaction_type": 4, "interaction_text": "The metabolism of felbamate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Conivaptan", "interaction_type": 4, "interaction_text": "The metabolism of Conivaptan can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Atomoxetine", "interaction_type": 4, "interaction_text": "The metabolism of Atomoxetine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mestranol", "interaction_type": 4, "interaction_text": "The metabolism of mestranol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "buprenorphine", "interaction_type": 4, "interaction_text": "The metabolism of buprenorphine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Temsirolimus", "interaction_type": 4, "interaction_text": "The metabolism of Temsirolimus can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "MOEXIPRIL", "interaction_type": 4, "interaction_text": "The metabolism of MOEXIPRIL can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "primidone", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Levonorgestrel", "interaction_type": 4, "interaction_text": "The metabolism of Levonorgestrel can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "thiopental", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenytoin", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Delavirdine", "interaction_type": 4, "interaction_text": "The metabolism of Delavirdine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "malathion", "interaction_type": 4, "interaction_text": "The metabolism of malathion can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nimodipine", "interaction_type": 4, "interaction_text": "The metabolism of nimodipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "nevirapine", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Apixaban", "interaction_type": 4, "interaction_text": "The metabolism of Apixaban can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Quinine", "interaction_type": 4, "interaction_text": "The metabolism of Quinine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "gabapentin", "interaction_type": 4, "interaction_text": "The metabolism of gabapentin can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "thiopental", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "meprobamate", "interaction_type": 4, "interaction_text": "The metabolism of meprobamate can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Elvitegravir", "interaction_type": 4, "interaction_text": "The metabolism of Elvitegravir can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "METHOHEXITAL", "interaction_type": 4, "interaction_text": "The metabolism of METHOHEXITAL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "methadone", "interaction_type": 4, "interaction_text": "The metabolism of methadone can be increased when combined with Delavirdine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Conivaptan", "interaction_type": 4, "interaction_text": "The metabolism of Conivaptan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Torasemide", "interaction_type": 4, "interaction_text": "The metabolism of Torasemide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mirtazapine", "interaction_type": 4, "interaction_text": "The metabolism of mirtazapine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "thioridazine", "interaction_type": 4, "interaction_text": "The metabolism of thioridazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Aprepitant", "interaction_type": 4, "interaction_text": "The metabolism of Aprepitant can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "tacrolimus", "interaction_type": 4, "interaction_text": "The metabolism of tacrolimus can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "carisoprodol", "interaction_type": 4, "interaction_text": "The metabolism of carisoprodol can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "thioridazine", "interaction_type": 4, "interaction_text": "The metabolism of thioridazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenytoin", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "primidone", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mestranol", "interaction_type": 4, "interaction_text": "The metabolism of mestranol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "primidone", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pitavastatin", "interaction_type": 4, "interaction_text": "The metabolism of Pitavastatin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "teniposide", "interaction_type": 4, "interaction_text": "The metabolism of teniposide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "salicylic acid", "interaction_type": 4, "interaction_text": "The metabolism of salicylic acid can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mefloquine", "interaction_type": 4, "interaction_text": "The metabolism of mefloquine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "metronidazole", "interaction_type": 4, "interaction_text": "The metabolism of metronidazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "thiopental", "interaction_type": 4, "interaction_text": "The metabolism of thiopental can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "primidone", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "felbamate", "interaction_type": 4, "interaction_text": "The metabolism of felbamate can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Pitavastatin", "interaction_type": 4, "interaction_text": "The metabolism of Pitavastatin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tapentadol", "interaction_type": 4, "interaction_text": "The metabolism of Tapentadol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "metoprolol", "interaction_type": 4, "interaction_text": "The metabolism of metoprolol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiopental", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mefloquine", "interaction_type": 4, "interaction_text": "The metabolism of mefloquine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "RIFABUTIN", "interaction_type": 4, "interaction_text": "The metabolism of RIFABUTIN can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ethanol", "interaction_type": 4, "interaction_text": "The metabolism of ethanol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fosinopril", "interaction_type": 4, "interaction_text": "The metabolism of fosinopril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "disopyramide", "interaction_type": 4, "interaction_text": "The metabolism of disopyramide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tapentadol", "interaction_type": 4, "interaction_text": "The metabolism of Tapentadol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Delavirdine", "interaction_type": 4, "interaction_text": "The metabolism of Delavirdine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Voriconazole", "interaction_type": 4, "interaction_text": "The metabolism of Voriconazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "metronidazole", "interaction_type": 4, "interaction_text": "The metabolism of metronidazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "timolol", "interaction_type": 4, "interaction_text": "The metabolism of timolol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "phenytoin", "interaction_type": 4, "interaction_text": "The metabolism of phenytoin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Atomoxetine", "interaction_type": 4, "interaction_text": "The metabolism of Atomoxetine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "phenobarbital", "interaction_type": 4, "interaction_text": "The metabolism of phenobarbital can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "teniposide", "interaction_type": 4, "interaction_text": "The metabolism of teniposide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chloramphenicol", "interaction_type": 4, "interaction_text": "The metabolism of chloramphenicol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "diethylstilbestrol", "interaction_type": 4, "interaction_text": "The metabolism of diethylstilbestrol can be increased when combined with griseofulvin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "malathion", "interaction_type": 4, "interaction_text": "The metabolism of malathion can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "mirtazapine", "interaction_type": 4, "interaction_text": "The metabolism of mirtazapine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Liotrix", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with Liotrix.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vemurafenib", "interaction_type": 4, "interaction_text": "The metabolism of Vemurafenib can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Vemurafenib", "interaction_type": 4, "interaction_text": "The metabolism of Vemurafenib can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "malathion", "interaction_type": 4, "interaction_text": "The metabolism of malathion can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "L-thyroxine", "interaction_type": 4, "interaction_text": "The metabolism of L-thyroxine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Clevidipine", "interaction_type": 4, "interaction_text": "The metabolism of Clevidipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "meperidine", "interaction_type": 4, "interaction_text": "The metabolism of meperidine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "buprenorphine", "interaction_type": 4, "interaction_text": "The metabolism of buprenorphine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "quinidine", "interaction_type": 4, "interaction_text": "The metabolism of quinidine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Clevidipine", "interaction_type": 4, "interaction_text": "The metabolism of Clevidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "amobarbital", "interaction_type": 4, "interaction_text": "The metabolism of amobarbital can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Fosphenytoin", "interaction_type": 4, "interaction_text": "The metabolism of Fosphenytoin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Bosentan", "interaction_type": 4, "interaction_text": "The metabolism of Bosentan can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with thiopental.", "severity": 2}
{"drug1": "primidone", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mianserin", "interaction_type": 4, "interaction_text": "The metabolism of mianserin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "VALPROIC ACID", "interaction_type": 4, "interaction_text": "The metabolism of VALPROIC ACID can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "liothyronine", "drug2": "dyphylline", "interaction_type": 4, "interaction_text": "The metabolism of dyphylline can be increased when combined with liothyronine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "nevirapine", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Saxagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Saxagliptin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lopinavir", "interaction_type": 4, "interaction_text": "The metabolism of Lopinavir can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "methadone", "interaction_type": 4, "interaction_text": "The metabolism of methadone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Bivalirudin", "interaction_type": 4, "interaction_text": "The metabolism of Bivalirudin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Sorafenib", "interaction_type": 4, "interaction_text": "The metabolism of Sorafenib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "efavirenz", "interaction_type": 4, "interaction_text": "The metabolism of efavirenz can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "primidone", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dienogest", "interaction_type": 4, "interaction_text": "The metabolism of Dienogest can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ETONOGESTREL", "interaction_type": 4, "interaction_text": "The metabolism of ETONOGESTREL can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "glutethimide", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with glutethimide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with thiopental.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "quinidine", "interaction_type": 4, "interaction_text": "The metabolism of quinidine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "diclofenac", "interaction_type": 4, "interaction_text": "The metabolism of diclofenac can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "captopril", "interaction_type": 4, "interaction_text": "The metabolism of captopril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "Fosphenytoin", "interaction_type": 4, "interaction_text": "The metabolism of Fosphenytoin can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "colchicine", "interaction_type": 4, "interaction_text": "The metabolism of colchicine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Torasemide", "interaction_type": 4, "interaction_text": "The metabolism of Torasemide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "indinavir", "interaction_type": 4, "interaction_text": "The metabolism of indinavir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nelfinavir", "interaction_type": 4, "interaction_text": "The metabolism of nelfinavir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with primidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Trabectedin", "interaction_type": 4, "interaction_text": "The metabolism of Trabectedin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amoxicillin", "interaction_type": 4, "interaction_text": "The metabolism of amoxicillin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "orphenadrine", "interaction_type": 4, "interaction_text": "The metabolism of orphenadrine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "efavirenz", "interaction_type": 4, "interaction_text": "The metabolism of efavirenz can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Elvitegravir", "interaction_type": 4, "interaction_text": "The metabolism of Elvitegravir can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Rotigotine", "interaction_type": 4, "interaction_text": "The metabolism of Rotigotine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "isoflurane", "interaction_type": 4, "interaction_text": "The metabolism of isoflurane can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "RIFABUTIN", "interaction_type": 4, "interaction_text": "The metabolism of RIFABUTIN can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "nelfinavir", "interaction_type": 4, "interaction_text": "The metabolism of nelfinavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Canagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Canagliflozin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "oxiconazole", "interaction_type": 4, "interaction_text": "The metabolism of oxiconazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "colchicine", "interaction_type": 4, "interaction_text": "The metabolism of colchicine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Quinine", "interaction_type": 4, "interaction_text": "The metabolism of Quinine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "metronidazole", "interaction_type": 4, "interaction_text": "The metabolism of metronidazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "metronidazole", "interaction_type": 4, "interaction_text": "The metabolism of metronidazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with primidone.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "liothyronine", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with liothyronine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "azelastine", "interaction_type": 4, "interaction_text": "The metabolism of azelastine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "formoterol", "interaction_type": 4, "interaction_text": "The metabolism of formoterol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dopamine", "interaction_type": 4, "interaction_text": "The metabolism of dopamine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "5-Fluorouracil", "interaction_type": 4, "interaction_text": "The metabolism of 5-Fluorouracil can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with griseofulvin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "famotidine", "interaction_type": 4, "interaction_text": "The metabolism of famotidine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methadone", "interaction_type": 4, "interaction_text": "The metabolism of methadone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "secobarbital", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with primidone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "meperidine", "interaction_type": 4, "interaction_text": "The metabolism of meperidine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "RANOLAZINE", "interaction_type": 4, "interaction_text": "The metabolism of RANOLAZINE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amoxicillin", "interaction_type": 4, "interaction_text": "The metabolism of amoxicillin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "promethazine", "interaction_type": 4, "interaction_text": "The metabolism of promethazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nevirapine", "interaction_type": 4, "interaction_text": "The metabolism of nevirapine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "quinidine", "interaction_type": 4, "interaction_text": "The metabolism of quinidine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ritonavir", "interaction_type": 4, "interaction_text": "The metabolism of ritonavir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ropinirole", "interaction_type": 4, "interaction_text": "The metabolism of ropinirole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Remikiren", "interaction_type": 4, "interaction_text": "The metabolism of Remikiren can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Torasemide", "interaction_type": 4, "interaction_text": "The metabolism of Torasemide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "norgestrel", "interaction_type": 4, "interaction_text": "The metabolism of norgestrel can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "famotidine", "interaction_type": 4, "interaction_text": "The metabolism of famotidine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "estazolam", "interaction_type": 4, "interaction_text": "The metabolism of estazolam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dantrolene", "interaction_type": 4, "interaction_text": "The metabolism of dantrolene can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "orphenadrine", "interaction_type": 4, "interaction_text": "The metabolism of orphenadrine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "amoxicillin", "interaction_type": 4, "interaction_text": "The metabolism of amoxicillin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "promethazine", "interaction_type": 4, "interaction_text": "The metabolism of promethazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sertraline", "interaction_type": 4, "interaction_text": "The metabolism of sertraline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "diclofenac", "interaction_type": 4, "interaction_text": "The metabolism of diclofenac can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiopental", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with thiopental.", "severity": 2}
{"drug1": "nevirapine", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ETONOGESTREL", "interaction_type": 4, "interaction_text": "The metabolism of ETONOGESTREL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with primidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Canagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Canagliflozin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Quinine", "interaction_type": 4, "interaction_text": "The metabolism of Quinine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Docosahexaenoic acid", "interaction_type": 4, "interaction_text": "The metabolism of Docosahexaenoic acid can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "glucosamine", "interaction_type": 4, "interaction_text": "The metabolism of glucosamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Pregabalin", "interaction_type": 4, "interaction_text": "The metabolism of Pregabalin can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "morphine", "interaction_type": 4, "interaction_text": "The metabolism of morphine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "mefloquine", "interaction_type": 4, "interaction_text": "The metabolism of mefloquine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pentobarbital", "interaction_type": 4, "interaction_text": "The metabolism of pentobarbital can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "METHOHEXITAL", "interaction_type": 4, "interaction_text": "The metabolism of METHOHEXITAL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "primidone", "interaction_type": 4, "interaction_text": "The metabolism of primidone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "mefloquine", "interaction_type": 4, "interaction_text": "The metabolism of mefloquine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with primidone.", "severity": 2}
{"drug1": "nafcillin", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Aprepitant", "interaction_type": 4, "interaction_text": "The metabolism of Aprepitant can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Levonorgestrel", "interaction_type": 4, "interaction_text": "The metabolism of Levonorgestrel can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Bosentan", "interaction_type": 4, "interaction_text": "The metabolism of Bosentan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "PONATINIB", "interaction_type": 4, "interaction_text": "The metabolism of PONATINIB can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "lisinopril", "interaction_type": 4, "interaction_text": "The metabolism of lisinopril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Conivaptan", "interaction_type": 4, "interaction_text": "The metabolism of Conivaptan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "norgestrel", "interaction_type": 4, "interaction_text": "The metabolism of norgestrel can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "promethazine", "interaction_type": 4, "interaction_text": "The metabolism of promethazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amoxicillin", "interaction_type": 4, "interaction_text": "The metabolism of amoxicillin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dabigatran etexilate", "interaction_type": 4, "interaction_text": "The metabolism of Dabigatran etexilate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dienogest", "interaction_type": 4, "interaction_text": "The metabolism of Dienogest can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "salicylic acid", "interaction_type": 4, "interaction_text": "The metabolism of salicylic acid can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rifampicin", "interaction_type": 4, "interaction_text": "The metabolism of Rifampicin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "salicylic acid", "interaction_type": 4, "interaction_text": "The metabolism of salicylic acid can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "thiopental", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "teniposide", "interaction_type": 4, "interaction_text": "The metabolism of teniposide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chloramphenicol", "interaction_type": 4, "interaction_text": "The metabolism of chloramphenicol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "phenytoin", "interaction_type": 4, "interaction_text": "The metabolism of phenytoin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "glucosamine", "interaction_type": 4, "interaction_text": "The metabolism of glucosamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "BISOPROLOL", "interaction_type": 4, "interaction_text": "The metabolism of BISOPROLOL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "mestranol", "interaction_type": 4, "interaction_text": "The metabolism of mestranol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "doxazosin", "interaction_type": 4, "interaction_text": "The metabolism of doxazosin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Canagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Canagliflozin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Cariprazine", "interaction_type": 4, "interaction_text": "The metabolism of Cariprazine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dapagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Dapagliflozin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with thiopental.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Fosphenytoin", "interaction_type": 4, "interaction_text": "The metabolism of Fosphenytoin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "glucosamine", "interaction_type": 4, "interaction_text": "The metabolism of glucosamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Medroxyprogesterone acetate", "interaction_type": 4, "interaction_text": "The metabolism of Medroxyprogesterone acetate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "nevirapine", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Bosentan", "interaction_type": 4, "interaction_text": "The metabolism of Bosentan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "chloramphenicol", "interaction_type": 4, "interaction_text": "The metabolism of chloramphenicol can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Brivaracetam", "interaction_type": 4, "interaction_text": "The metabolism of Brivaracetam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "IDARUBICIN", "interaction_type": 4, "interaction_text": "The metabolism of IDARUBICIN can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "thiopental", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "malathion", "interaction_type": 4, "interaction_text": "The metabolism of malathion can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "epinastine", "interaction_type": 4, "interaction_text": "The metabolism of epinastine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "isoflurane", "interaction_type": 4, "interaction_text": "The metabolism of isoflurane can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "amobarbital", "interaction_type": 4, "interaction_text": "The metabolism of amobarbital can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "SAQUINAVIR", "interaction_type": 4, "interaction_text": "The metabolism of SAQUINAVIR can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Riociguat", "interaction_type": 4, "interaction_text": "The metabolism of Riociguat can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with thiopental.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Delavirdine", "interaction_type": 4, "interaction_text": "The metabolism of Delavirdine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "azelastine", "interaction_type": 4, "interaction_text": "The metabolism of azelastine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ethanol", "interaction_type": 4, "interaction_text": "The metabolism of ethanol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "L-thyroxine", "interaction_type": 4, "interaction_text": "The metabolism of L-thyroxine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Temsirolimus", "interaction_type": 4, "interaction_text": "The metabolism of Temsirolimus can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "pentobarbital", "interaction_type": 4, "interaction_text": "The metabolism of pentobarbital can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Pitavastatin", "interaction_type": 4, "interaction_text": "The metabolism of Pitavastatin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "phenytoin", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ketoprofen", "interaction_type": 4, "interaction_text": "The metabolism of ketoprofen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Pinaverium", "interaction_type": 4, "interaction_text": "The metabolism of Pinaverium can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "quinidine", "interaction_type": 4, "interaction_text": "The metabolism of quinidine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "L-thyroxine", "interaction_type": 4, "interaction_text": "The metabolism of L-thyroxine can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nafcillin", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Arformoterol", "interaction_type": 4, "interaction_text": "The metabolism of Arformoterol can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "nevirapine", "interaction_type": 4, "interaction_text": "The metabolism of nevirapine can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ritonavir", "interaction_type": 4, "interaction_text": "The metabolism of ritonavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "primidone", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Sitagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Sitagliptin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "diclofenac", "interaction_type": 4, "interaction_text": "The metabolism of diclofenac can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "thalidomide", "interaction_type": 4, "interaction_text": "The metabolism of thalidomide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rifampicin", "interaction_type": 4, "interaction_text": "The metabolism of Rifampicin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ticlopidine", "interaction_type": 4, "interaction_text": "The metabolism of ticlopidine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ifosfamide", "interaction_type": 4, "interaction_text": "The metabolism of ifosfamide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "thalidomide", "interaction_type": 4, "interaction_text": "The metabolism of thalidomide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "nilutamide", "interaction_type": 4, "interaction_text": "The metabolism of nilutamide can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "primidone", "interaction_type": 4, "interaction_text": "The metabolism of primidone can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Torasemide", "interaction_type": 4, "interaction_text": "The metabolism of Torasemide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Liotrix", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with Liotrix.", "severity": 2}
{"drug1": "primidone", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "KETAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of KETAZOLAM can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "RANOLAZINE", "interaction_type": 4, "interaction_text": "The metabolism of RANOLAZINE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "estradiol", "interaction_type": 4, "interaction_text": "The metabolism of estradiol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with thiopental.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with primidone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tacrolimus", "interaction_type": 4, "interaction_text": "The metabolism of tacrolimus can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dienogest", "interaction_type": 4, "interaction_text": "The metabolism of Dienogest can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clozapine", "interaction_type": 4, "interaction_text": "The metabolism of clozapine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Levonorgestrel", "interaction_type": 4, "interaction_text": "The metabolism of Levonorgestrel can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "pimozide", "interaction_type": 4, "interaction_text": "The metabolism of pimozide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "nevirapine", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "digoxin", "interaction_type": 4, "interaction_text": "The metabolism of digoxin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "indinavir", "interaction_type": 4, "interaction_text": "The metabolism of indinavir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Fosamprenavir", "interaction_type": 4, "interaction_text": "The metabolism of Fosamprenavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Delavirdine", "interaction_type": 4, "interaction_text": "The metabolism of Delavirdine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Canagliflozin", "interaction_type": 4, "interaction_text": "The metabolism of Canagliflozin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "metronidazole", "interaction_type": 4, "interaction_text": "The metabolism of metronidazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "doxazosin", "interaction_type": 4, "interaction_text": "The metabolism of doxazosin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "carisoprodol", "interaction_type": 4, "interaction_text": "The metabolism of carisoprodol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Torasemide", "interaction_type": 4, "interaction_text": "The metabolism of Torasemide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "timolol", "interaction_type": 4, "interaction_text": "The metabolism of timolol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "meprobamate", "interaction_type": 4, "interaction_text": "The metabolism of meprobamate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mirtazapine", "interaction_type": 4, "interaction_text": "The metabolism of mirtazapine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "calcitriol", "interaction_type": 4, "interaction_text": "The metabolism of calcitriol can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ecabet", "interaction_type": 4, "interaction_text": "The metabolism of Ecabet can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "timolol", "interaction_type": 4, "interaction_text": "The metabolism of timolol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "meprobamate", "interaction_type": 4, "interaction_text": "The metabolism of meprobamate can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "azelastine", "interaction_type": 4, "interaction_text": "The metabolism of azelastine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "felbamate", "interaction_type": 4, "interaction_text": "The metabolism of felbamate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pimecrolimus", "interaction_type": 4, "interaction_text": "The metabolism of Pimecrolimus can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "thiopental", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with thiopental.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "felbamate", "interaction_type": 4, "interaction_text": "The metabolism of felbamate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "oxiconazole", "interaction_type": 4, "interaction_text": "The metabolism of oxiconazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "zalcitabine", "interaction_type": 4, "interaction_text": "The metabolism of zalcitabine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "antipyrine", "interaction_type": 4, "interaction_text": "The metabolism of antipyrine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with primidone.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "primidone", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pilocarpine", "interaction_type": 4, "interaction_text": "The metabolism of pilocarpine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "famciclovir", "interaction_type": 4, "interaction_text": "The metabolism of famciclovir can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "liothyronine", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with liothyronine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "primidone", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ambrisentan", "interaction_type": 4, "interaction_text": "The metabolism of Ambrisentan can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "norgestrel", "interaction_type": 4, "interaction_text": "The metabolism of norgestrel can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Quinine", "interaction_type": 4, "interaction_text": "The metabolism of Quinine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lopinavir", "interaction_type": 4, "interaction_text": "The metabolism of Lopinavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "temazepam", "interaction_type": 4, "interaction_text": "The metabolism of temazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "finasteride", "interaction_type": 4, "interaction_text": "The metabolism of finasteride can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ropinirole", "interaction_type": 4, "interaction_text": "The metabolism of ropinirole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "RIFABUTIN", "interaction_type": 4, "interaction_text": "The metabolism of RIFABUTIN can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ospemifene", "interaction_type": 4, "interaction_text": "The metabolism of Ospemifene can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Rifampicin", "interaction_type": 4, "interaction_text": "The metabolism of Rifampicin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tenoxicam", "interaction_type": 4, "interaction_text": "The metabolism of tenoxicam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Atazanavir", "interaction_type": 4, "interaction_text": "The metabolism of Atazanavir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "diphenhydramine", "interaction_type": 4, "interaction_text": "The metabolism of diphenhydramine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "atorvastatin", "interaction_type": 4, "interaction_text": "The metabolism of atorvastatin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nafcillin", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clopidogrel", "interaction_type": 4, "interaction_text": "The metabolism of clopidogrel can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tacrolimus", "interaction_type": 4, "interaction_text": "The metabolism of tacrolimus can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "secobarbital", "interaction_type": 4, "interaction_text": "The metabolism of secobarbital can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "phenytoin", "interaction_type": 4, "interaction_text": "The metabolism of phenytoin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fluvastatin", "interaction_type": 4, "interaction_text": "The metabolism of fluvastatin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fosamprenavir", "interaction_type": 4, "interaction_text": "The metabolism of Fosamprenavir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Conivaptan", "interaction_type": 4, "interaction_text": "The metabolism of Conivaptan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "metoprolol", "interaction_type": 4, "interaction_text": "The metabolism of metoprolol can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "rapamycin", "interaction_type": 4, "interaction_text": "The metabolism of rapamycin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with thiopental.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tiotropium", "interaction_type": 4, "interaction_text": "The metabolism of Tiotropium can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cytarabine", "interaction_type": 4, "interaction_text": "The metabolism of cytarabine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "SAQUINAVIR", "interaction_type": 4, "interaction_text": "The metabolism of SAQUINAVIR can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tegafur", "interaction_type": 4, "interaction_text": "The metabolism of tegafur can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Palonosetron", "interaction_type": 4, "interaction_text": "The metabolism of Palonosetron can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "ethinyl estradiol", "interaction_type": 4, "interaction_text": "The metabolism of ethinyl estradiol can be increased when combined with griseofulvin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Mexiletine", "interaction_type": 4, "interaction_text": "The metabolism of Mexiletine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "etizolam", "interaction_type": 4, "interaction_text": "The metabolism of etizolam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Levocetirizine", "interaction_type": 4, "interaction_text": "The metabolism of Levocetirizine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ramelteon", "interaction_type": 4, "interaction_text": "The metabolism of Ramelteon can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "malathion", "interaction_type": 4, "interaction_text": "The metabolism of malathion can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flurbiprofen", "interaction_type": 4, "interaction_text": "The metabolism of flurbiprofen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pioglitazone", "interaction_type": 4, "interaction_text": "The metabolism of Pioglitazone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "sulfisoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfisoxazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "norgestrel", "interaction_type": 4, "interaction_text": "The metabolism of norgestrel can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chlorpheniramine", "interaction_type": 4, "interaction_text": "The metabolism of chlorpheniramine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Escitalopram", "interaction_type": 4, "interaction_text": "The metabolism of Escitalopram can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chenodeoxycholic acid", "interaction_type": 4, "interaction_text": "The metabolism of chenodeoxycholic acid can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "METHSUXIMIDE", "interaction_type": 4, "interaction_text": "The metabolism of METHSUXIMIDE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenytoin", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "podophyllotoxin", "interaction_type": 4, "interaction_text": "The metabolism of podophyllotoxin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bromocriptine", "interaction_type": 4, "interaction_text": "The metabolism of bromocriptine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "colchicine", "interaction_type": 4, "interaction_text": "The metabolism of colchicine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Levonorgestrel", "interaction_type": 4, "interaction_text": "The metabolism of Levonorgestrel can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "nevirapine", "drug2": "docetaxel", "interaction_type": 4, "interaction_text": "The metabolism of docetaxel can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fosamprenavir", "interaction_type": 4, "interaction_text": "The metabolism of Fosamprenavir can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ketoconazole", "interaction_type": 4, "interaction_text": "The metabolism of ketoconazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "vindesine", "interaction_type": 4, "interaction_text": "The metabolism of vindesine can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "quazepam", "interaction_type": 4, "interaction_text": "The metabolism of quazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "glutethimide", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with glutethimide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Valbenazine", "interaction_type": 4, "interaction_text": "The metabolism of Valbenazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Perospirone", "interaction_type": 4, "interaction_text": "The metabolism of Perospirone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bezafibrate", "interaction_type": 4, "interaction_text": "The metabolism of bezafibrate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amprenavir", "interaction_type": 4, "interaction_text": "The metabolism of amprenavir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "vinorelbine", "interaction_type": 4, "interaction_text": "The metabolism of vinorelbine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "primidone", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clorazepate", "interaction_type": 4, "interaction_text": "The metabolism of clorazepate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "triamcinolone", "interaction_type": 4, "interaction_text": "The metabolism of triamcinolone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "efavirenz", "interaction_type": 4, "interaction_text": "The metabolism of efavirenz can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "testosterone", "interaction_type": 4, "interaction_text": "The metabolism of testosterone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Darunavir", "interaction_type": 4, "interaction_text": "The metabolism of Darunavir can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Halofantrine", "interaction_type": 4, "interaction_text": "The metabolism of Halofantrine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "histamine", "interaction_type": 4, "interaction_text": "The metabolism of histamine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "mestranol", "interaction_type": 4, "interaction_text": "The metabolism of mestranol can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Estrone sulfate", "interaction_type": 4, "interaction_text": "The metabolism of Estrone sulfate can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mianserin", "interaction_type": 4, "interaction_text": "The metabolism of mianserin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "leflunomide", "interaction_type": 4, "interaction_text": "The metabolism of leflunomide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "teniposide", "interaction_type": 4, "interaction_text": "The metabolism of teniposide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Dabrafenib", "interaction_type": 4, "interaction_text": "The metabolism of Dabrafenib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "methyltestosterone", "interaction_type": 4, "interaction_text": "The metabolism of methyltestosterone can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pomalidomide", "interaction_type": 4, "interaction_text": "The metabolism of Pomalidomide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "ketoconazole", "interaction_type": 4, "interaction_text": "The metabolism of ketoconazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Mephobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Mephobarbital can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "indinavir", "interaction_type": 4, "interaction_text": "The metabolism of indinavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Coenzyme Q10", "interaction_type": 4, "interaction_text": "The metabolism of Coenzyme Q10 can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "fluoxetine", "interaction_type": 4, "interaction_text": "The metabolism of fluoxetine can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Prasugrel", "interaction_type": 4, "interaction_text": "The metabolism of Prasugrel can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "montelukast", "interaction_type": 4, "interaction_text": "The metabolism of montelukast can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "chlordiazepoxide", "interaction_type": 4, "interaction_text": "The metabolism of chlordiazepoxide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nevirapine", "interaction_type": 4, "interaction_text": "The metabolism of nevirapine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with primidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "chlorpropamide", "interaction_type": 4, "interaction_text": "The metabolism of chlorpropamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Aprepitant", "interaction_type": 4, "interaction_text": "The metabolism of Aprepitant can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Isoflurophate", "interaction_type": 4, "interaction_text": "The metabolism of Isoflurophate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "thioridazine", "interaction_type": 4, "interaction_text": "The metabolism of thioridazine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "glimepiride", "interaction_type": 4, "interaction_text": "The metabolism of glimepiride can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vilanterol", "interaction_type": 4, "interaction_text": "The metabolism of Vilanterol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "OLODATEROL", "interaction_type": 4, "interaction_text": "The metabolism of OLODATEROL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Enasidenib", "interaction_type": 4, "interaction_text": "The metabolism of Enasidenib can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "estrone", "interaction_type": 4, "interaction_text": "The metabolism of estrone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "phenoxybenzamine", "interaction_type": 4, "interaction_text": "The metabolism of phenoxybenzamine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sildenafil", "interaction_type": 4, "interaction_text": "The metabolism of sildenafil can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "caffeine", "interaction_type": 4, "interaction_text": "The metabolism of caffeine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "azithromycin", "interaction_type": 4, "interaction_text": "The metabolism of azithromycin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dofetilide", "interaction_type": 4, "interaction_text": "The metabolism of Dofetilide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "glipizide", "interaction_type": 4, "interaction_text": "The metabolism of glipizide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Melatonin", "interaction_type": 4, "interaction_text": "The metabolism of Melatonin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cephalexin", "interaction_type": 4, "interaction_text": "The metabolism of cephalexin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "doxazosin", "interaction_type": 4, "interaction_text": "The metabolism of doxazosin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dehydroepiandrosterone", "interaction_type": 4, "interaction_text": "The metabolism of Dehydroepiandrosterone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "carbamazepine", "interaction_type": 4, "interaction_text": "The metabolism of carbamazepine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "VERAPAMIL", "interaction_type": 4, "interaction_text": "The metabolism of VERAPAMIL can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "suprofen", "interaction_type": 4, "interaction_text": "The metabolism of suprofen can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Pipotiazine", "interaction_type": 4, "interaction_text": "The metabolism of Pipotiazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Aceclofenac", "interaction_type": 4, "interaction_text": "The metabolism of Aceclofenac can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zaltoprofen", "interaction_type": 4, "interaction_text": "The metabolism of zaltoprofen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Artemether", "interaction_type": 4, "interaction_text": "The metabolism of Artemether can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "CORTISONE ACETATE", "interaction_type": 4, "interaction_text": "The metabolism of CORTISONE ACETATE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clofazimine", "interaction_type": 4, "interaction_text": "The metabolism of clofazimine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "colchicine", "interaction_type": 4, "interaction_text": "The metabolism of colchicine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dapsone", "interaction_type": 4, "interaction_text": "The metabolism of dapsone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "oxazepam", "interaction_type": 4, "interaction_text": "The metabolism of oxazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Repaglinide", "interaction_type": 4, "interaction_text": "The metabolism of Repaglinide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "naloxone", "interaction_type": 4, "interaction_text": "The metabolism of naloxone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Fulvestrant", "interaction_type": 4, "interaction_text": "The metabolism of Fulvestrant can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "domperidone", "interaction_type": 4, "interaction_text": "The metabolism of domperidone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with primidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "midazolam", "interaction_type": 4, "interaction_text": "The metabolism of midazolam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "VALPROIC ACID", "interaction_type": 4, "interaction_text": "The metabolism of VALPROIC ACID can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "phenobarbital", "interaction_type": 4, "interaction_text": "The metabolism of phenobarbital can be increased when combined with pyridoxine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Neratinib", "interaction_type": 4, "interaction_text": "The metabolism of Neratinib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "trazodone", "interaction_type": 4, "interaction_text": "The metabolism of trazodone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Bexarotene", "interaction_type": 4, "interaction_text": "The metabolism of Bexarotene can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ciclesonide", "interaction_type": 4, "interaction_text": "The metabolism of Ciclesonide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "thiopental", "interaction_type": 4, "interaction_text": "The metabolism of thiopental can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dicumarol", "interaction_type": 4, "interaction_text": "The metabolism of dicumarol can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zidovudine", "interaction_type": 4, "interaction_text": "The metabolism of zidovudine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dihydroergotamine", "interaction_type": 4, "interaction_text": "The metabolism of dihydroergotamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flutamide", "interaction_type": 4, "interaction_text": "The metabolism of flutamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "phenindione", "interaction_type": 4, "interaction_text": "The metabolism of phenindione can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "irbesartan", "interaction_type": 4, "interaction_text": "The metabolism of irbesartan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "carvedilol", "interaction_type": 4, "interaction_text": "The metabolism of carvedilol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "gemfibrozil", "interaction_type": 4, "interaction_text": "The metabolism of gemfibrozil can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "ibuprofen", "interaction_type": 4, "interaction_text": "The metabolism of ibuprofen can be increased when combined with primidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ADINAZOLAM", "interaction_type": 4, "interaction_text": "The metabolism of ADINAZOLAM can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "vincristine", "interaction_type": 4, "interaction_text": "The metabolism of vincristine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "aspirin", "interaction_type": 4, "interaction_text": "The metabolism of aspirin can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zafirlukast", "interaction_type": 4, "interaction_text": "The metabolism of zafirlukast can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "IMIQUIMOD", "interaction_type": 4, "interaction_text": "The metabolism of IMIQUIMOD can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "SUFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of SUFENTANIL can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Eplerenone", "interaction_type": 4, "interaction_text": "The metabolism of Eplerenone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "lovastatin", "interaction_type": 4, "interaction_text": "The metabolism of lovastatin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "benzyl alcohol", "interaction_type": 4, "interaction_text": "The metabolism of benzyl alcohol can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "TAMSULOSIN", "interaction_type": 4, "interaction_text": "The metabolism of TAMSULOSIN can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "digitoxin", "interaction_type": 4, "interaction_text": "The metabolism of digitoxin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "thiopental", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Risedronic acid", "interaction_type": 4, "interaction_text": "The metabolism of Risedronic acid can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Propoxyphene napsylate", "interaction_type": 4, "interaction_text": "The metabolism of Propoxyphene napsylate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "primidone", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "argatroban", "interaction_type": 4, "interaction_text": "The metabolism of argatroban can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "disopyramide", "interaction_type": 4, "interaction_text": "The metabolism of disopyramide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Dothiepin", "interaction_type": 4, "interaction_text": "The metabolism of Dothiepin can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "DEFLAZACORT", "interaction_type": 4, "interaction_text": "The metabolism of DEFLAZACORT can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "pravastatin", "interaction_type": 4, "interaction_text": "The metabolism of pravastatin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "desipramine", "interaction_type": 4, "interaction_text": "The metabolism of desipramine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nefazodone", "interaction_type": 4, "interaction_text": "The metabolism of nefazodone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Cabozantinib", "interaction_type": 4, "interaction_text": "The metabolism of Cabozantinib can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dabrafenib", "interaction_type": 4, "interaction_text": "The metabolism of Dabrafenib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sulfadiazine", "interaction_type": 4, "interaction_text": "The metabolism of sulfadiazine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mefloquine", "interaction_type": 4, "interaction_text": "The metabolism of mefloquine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 4, "interaction_text": "The metabolism of Medroxyprogesterone acetate can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fosamprenavir", "interaction_type": 4, "interaction_text": "The metabolism of Fosamprenavir can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with Bosentan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "triazolam", "interaction_type": 4, "interaction_text": "The metabolism of triazolam can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dolasetron", "interaction_type": 4, "interaction_text": "The metabolism of dolasetron can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tretinoin", "interaction_type": 4, "interaction_text": "The metabolism of tretinoin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of nitrazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "quinacrine", "interaction_type": 4, "interaction_text": "The metabolism of quinacrine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tianeptine", "interaction_type": 4, "interaction_text": "The metabolism of Tianeptine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Propacetamol", "interaction_type": 4, "interaction_text": "The metabolism of Propacetamol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "malathion", "interaction_type": 4, "interaction_text": "The metabolism of malathion can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "barnidipine", "interaction_type": 4, "interaction_text": "The metabolism of barnidipine can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Cevimeline", "interaction_type": 4, "interaction_text": "The metabolism of Cevimeline can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "malathion", "interaction_type": 4, "interaction_text": "The metabolism of malathion can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Levomilnacipran", "interaction_type": 4, "interaction_text": "The metabolism of Levomilnacipran can be increased when combined with primidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "roxithromycin", "interaction_type": 4, "interaction_text": "The metabolism of roxithromycin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "TROLEANDOMYCIN", "interaction_type": 4, "interaction_text": "The metabolism of TROLEANDOMYCIN can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "codeine", "interaction_type": 4, "interaction_text": "The metabolism of codeine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clonidine", "interaction_type": 4, "interaction_text": "The metabolism of clonidine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tinidazole", "interaction_type": 4, "interaction_text": "The metabolism of tinidazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Paricalcitol", "interaction_type": 4, "interaction_text": "The metabolism of Paricalcitol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "metronidazole", "interaction_type": 4, "interaction_text": "The metabolism of metronidazole can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "5-Fluorouracil", "interaction_type": 4, "interaction_text": "The metabolism of 5-Fluorouracil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Almotriptan", "interaction_type": 4, "interaction_text": "The metabolism of Almotriptan can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with thiopental.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "astemizole", "interaction_type": 4, "interaction_text": "The metabolism of astemizole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "propranolol", "interaction_type": 4, "interaction_text": "The metabolism of propranolol can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "moclobemide", "interaction_type": 4, "interaction_text": "The metabolism of moclobemide can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "vinblastine", "interaction_type": 4, "interaction_text": "The metabolism of vinblastine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nortriptyline", "interaction_type": 4, "interaction_text": "The metabolism of nortriptyline can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ethosuximide", "interaction_type": 4, "interaction_text": "The metabolism of ethosuximide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nafcillin", "drug2": "diltiazem", "interaction_type": 4, "interaction_text": "The metabolism of diltiazem can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "doxazosin", "interaction_type": 4, "interaction_text": "The metabolism of doxazosin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "thiopental", "interaction_type": 4, "interaction_text": "The metabolism of thiopental can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Brigatinib", "interaction_type": 4, "interaction_text": "The metabolism of Brigatinib can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lorcaserin", "interaction_type": 4, "interaction_text": "The metabolism of Lorcaserin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tiagabine", "interaction_type": 4, "interaction_text": "The metabolism of tiagabine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "epoprostenol", "interaction_type": 4, "interaction_text": "The metabolism of epoprostenol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "indinavir", "interaction_type": 4, "interaction_text": "The metabolism of indinavir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "diazepam", "interaction_type": 4, "interaction_text": "The metabolism of diazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "aminophylline", "interaction_type": 4, "interaction_text": "The metabolism of aminophylline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dexlansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of dexlansoprazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clotiazepam", "interaction_type": 4, "interaction_text": "The metabolism of clotiazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Treprostinil", "interaction_type": 4, "interaction_text": "The metabolism of Treprostinil can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dorzolamide", "interaction_type": 4, "interaction_text": "The metabolism of dorzolamide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Aprepitant", "interaction_type": 4, "interaction_text": "The metabolism of Aprepitant can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "LESINURAD", "interaction_type": 4, "interaction_text": "The metabolism of LESINURAD can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ximelagatran", "interaction_type": 4, "interaction_text": "The metabolism of Ximelagatran can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "bepridil", "interaction_type": 4, "interaction_text": "The metabolism of bepridil can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "imipramine", "interaction_type": 4, "interaction_text": "The metabolism of imipramine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "selegiline", "interaction_type": 4, "interaction_text": "The metabolism of selegiline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Lopinavir", "interaction_type": 4, "interaction_text": "The metabolism of Lopinavir can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "meperidine", "interaction_type": 4, "interaction_text": "The metabolism of meperidine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "loratadine", "interaction_type": 4, "interaction_text": "The metabolism of loratadine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chlorzoxazone", "interaction_type": 4, "interaction_text": "The metabolism of chlorzoxazone can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "L-thyroxine", "interaction_type": 4, "interaction_text": "The metabolism of L-thyroxine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "promazine", "interaction_type": 4, "interaction_text": "The metabolism of promazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "isradipine", "interaction_type": 4, "interaction_text": "The metabolism of isradipine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fesoterodine", "interaction_type": 4, "interaction_text": "The metabolism of Fesoterodine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Eltrombopag", "interaction_type": 4, "interaction_text": "The metabolism of Eltrombopag can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Asenapine", "interaction_type": 4, "interaction_text": "The metabolism of Asenapine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "granisetron", "interaction_type": 4, "interaction_text": "The metabolism of granisetron can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ambroxol", "interaction_type": 4, "interaction_text": "The metabolism of ambroxol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "terbinafine", "interaction_type": 4, "interaction_text": "The metabolism of terbinafine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "PRIMAQUINE", "interaction_type": 4, "interaction_text": "The metabolism of PRIMAQUINE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Avanafil", "interaction_type": 4, "interaction_text": "The metabolism of Avanafil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "lansoprazole", "interaction_type": 4, "interaction_text": "The metabolism of lansoprazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ALFENTANIL", "interaction_type": 4, "interaction_text": "The metabolism of ALFENTANIL can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "budesonide", "interaction_type": 4, "interaction_text": "The metabolism of budesonide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tetracycline", "interaction_type": 4, "interaction_text": "The metabolism of tetracycline can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "spiramycin", "interaction_type": 4, "interaction_text": "The metabolism of spiramycin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "SERTINDOLE", "interaction_type": 4, "interaction_text": "The metabolism of SERTINDOLE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Safinamide", "interaction_type": 4, "interaction_text": "The metabolism of Safinamide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "simvastatin", "interaction_type": 4, "interaction_text": "The metabolism of simvastatin can be increased when combined with primidone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "primidone", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Hexobarbital", "interaction_type": 4, "interaction_text": "The metabolism of Hexobarbital can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nilutamide", "interaction_type": 4, "interaction_text": "The metabolism of nilutamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amitriptyline", "interaction_type": 4, "interaction_text": "The metabolism of amitriptyline can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nelfinavir", "interaction_type": 4, "interaction_text": "The metabolism of nelfinavir can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "modafinil", "interaction_type": 4, "interaction_text": "The metabolism of modafinil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "perphenazine", "interaction_type": 4, "interaction_text": "The metabolism of perphenazine can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "NAPROXEN", "interaction_type": 4, "interaction_text": "The metabolism of NAPROXEN can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "paramethasone", "interaction_type": 4, "interaction_text": "The metabolism of paramethasone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "disulfiram", "interaction_type": 4, "interaction_text": "The metabolism of disulfiram can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "propofol", "interaction_type": 4, "interaction_text": "The metabolism of propofol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "secobarbital", "drug2": "valsartan", "interaction_type": 4, "interaction_text": "The metabolism of valsartan can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ketoconazole", "interaction_type": 4, "interaction_text": "The metabolism of ketoconazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Silodosin", "interaction_type": 4, "interaction_text": "The metabolism of Silodosin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "thalidomide", "interaction_type": 4, "interaction_text": "The metabolism of thalidomide can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Iloperidone", "interaction_type": 4, "interaction_text": "The metabolism of Iloperidone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "progesterone", "interaction_type": 4, "interaction_text": "The metabolism of progesterone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Copanlisib", "interaction_type": 4, "interaction_text": "The metabolism of Copanlisib can be increased when combined with primidone.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "mestranol", "interaction_type": 4, "interaction_text": "The metabolism of mestranol can be increased when combined with griseofulvin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "salicylic acid", "interaction_type": 4, "interaction_text": "The metabolism of salicylic acid can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Salmeterol", "interaction_type": 4, "interaction_text": "The metabolism of Salmeterol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Asunaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Asunaprevir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Venetoclax", "interaction_type": 4, "interaction_text": "The metabolism of Venetoclax can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Mirabegron", "interaction_type": 4, "interaction_text": "The metabolism of Mirabegron can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nisoldipine", "interaction_type": 4, "interaction_text": "The metabolism of nisoldipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pantoprazole", "interaction_type": 4, "interaction_text": "The metabolism of pantoprazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "citalopram", "interaction_type": 4, "interaction_text": "The metabolism of citalopram can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Eletriptan", "interaction_type": 4, "interaction_text": "The metabolism of Eletriptan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Liotrix", "drug2": "dyphylline", "interaction_type": 4, "interaction_text": "The metabolism of dyphylline can be increased when combined with Liotrix.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "PERINDOPRIL", "interaction_type": 4, "interaction_text": "The metabolism of PERINDOPRIL can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "etodolac", "interaction_type": 4, "interaction_text": "The metabolism of etodolac can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Candesartan cilexetil", "interaction_type": 4, "interaction_text": "The metabolism of Candesartan cilexetil can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ranitidine", "interaction_type": 4, "interaction_text": "The metabolism of ranitidine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lomitapide", "interaction_type": 4, "interaction_text": "The metabolism of Lomitapide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cyclosporin A", "interaction_type": 4, "interaction_text": "The metabolism of cyclosporin A can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "quinapril", "interaction_type": 4, "interaction_text": "The metabolism of quinapril can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "lidocaine", "interaction_type": 4, "interaction_text": "The metabolism of lidocaine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Permethrin", "interaction_type": 4, "interaction_text": "The metabolism of Permethrin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "Baricitinib", "interaction_type": 4, "interaction_text": "The metabolism of Baricitinib can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "disopyramide", "interaction_type": 4, "interaction_text": "The metabolism of disopyramide can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "doxepin", "interaction_type": 4, "interaction_text": "The metabolism of doxepin can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "alosetron", "interaction_type": 4, "interaction_text": "The metabolism of alosetron can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ketamine", "interaction_type": 4, "interaction_text": "The metabolism of ketamine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lumefantrine", "interaction_type": 4, "interaction_text": "The metabolism of Lumefantrine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tazarotene", "interaction_type": 4, "interaction_text": "The metabolism of tazarotene can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Paritaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Paritaprevir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "sibutramine", "interaction_type": 4, "interaction_text": "The metabolism of sibutramine can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "oxymorphone", "interaction_type": 4, "interaction_text": "The metabolism of oxymorphone can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cyclophosphamide", "interaction_type": 4, "interaction_text": "The metabolism of cyclophosphamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "clindamycin", "interaction_type": 4, "interaction_text": "The metabolism of clindamycin can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "benztropine", "interaction_type": 4, "interaction_text": "The metabolism of benztropine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tolbutamide", "interaction_type": 4, "interaction_text": "The metabolism of tolbutamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "oxaprozin", "interaction_type": 4, "interaction_text": "The metabolism of oxaprozin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "thalidomide", "interaction_type": 4, "interaction_text": "The metabolism of thalidomide can be increased when combined with Lopinavir.", "severity": 2}
{"drug1": "nevirapine", "drug2": "hydromorphone", "interaction_type": 4, "interaction_text": "The metabolism of hydromorphone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "flurazepam", "interaction_type": 4, "interaction_text": "The metabolism of flurazepam can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "rabeprazole", "interaction_type": 4, "interaction_text": "The metabolism of rabeprazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "halothane", "interaction_type": 4, "interaction_text": "The metabolism of halothane can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "prazepam", "interaction_type": 4, "interaction_text": "The metabolism of prazepam can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "manidipine", "interaction_type": 4, "interaction_text": "The metabolism of manidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "pergolide", "interaction_type": 4, "interaction_text": "The metabolism of pergolide can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Efonidipine", "interaction_type": 4, "interaction_text": "The metabolism of Efonidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lacidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lacidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "propoxyphene", "interaction_type": 4, "interaction_text": "The metabolism of propoxyphene can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Azelnidipine", "interaction_type": 4, "interaction_text": "The metabolism of Azelnidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Benidipine", "interaction_type": 4, "interaction_text": "The metabolism of Benidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cilnidipine", "interaction_type": 4, "interaction_text": "The metabolism of cilnidipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "mebendazole", "interaction_type": 4, "interaction_text": "The metabolism of mebendazole can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "CABAZITAXEL", "interaction_type": 4, "interaction_text": "The metabolism of CABAZITAXEL can be increased when combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clomipramine", "interaction_type": 4, "interaction_text": "The metabolism of clomipramine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "acetaminophen", "interaction_type": 4, "interaction_text": "The metabolism of acetaminophen can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Fingolimod", "interaction_type": 4, "interaction_text": "The metabolism of Fingolimod can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rimonabant", "interaction_type": 4, "interaction_text": "The metabolism of Rimonabant can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lornoxicam", "interaction_type": 4, "interaction_text": "The metabolism of Lornoxicam can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ergocalciferol", "interaction_type": 4, "interaction_text": "The metabolism of ergocalciferol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "warfarin", "interaction_type": 4, "interaction_text": "The metabolism of warfarin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "raloxifene", "interaction_type": 4, "interaction_text": "The metabolism of raloxifene can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "celecoxib", "interaction_type": 4, "interaction_text": "The metabolism of celecoxib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Ombitasvir", "interaction_type": 4, "interaction_text": "The metabolism of Ombitasvir can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ipratropium", "interaction_type": 4, "interaction_text": "The metabolism of ipratropium can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methadone", "interaction_type": 4, "interaction_text": "The metabolism of methadone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bromazepam", "interaction_type": 4, "interaction_text": "The metabolism of bromazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "indapamide", "interaction_type": 4, "interaction_text": "The metabolism of indapamide can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "omeprazole", "interaction_type": 4, "interaction_text": "The metabolism of omeprazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pyrazinamide", "interaction_type": 4, "interaction_text": "The metabolism of pyrazinamide can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sulfamethoxazole", "interaction_type": 4, "interaction_text": "The metabolism of sulfamethoxazole can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "trimipramine", "interaction_type": 4, "interaction_text": "The metabolism of trimipramine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "glyburide", "interaction_type": 4, "interaction_text": "The metabolism of glyburide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Sitaxsentan", "interaction_type": 4, "interaction_text": "The metabolism of Sitaxsentan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Cinacalcet", "interaction_type": 4, "interaction_text": "The metabolism of Cinacalcet can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "flunitrazepam", "interaction_type": 4, "interaction_text": "The metabolism of flunitrazepam can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Rifampicin", "interaction_type": 4, "interaction_text": "The metabolism of Rifampicin can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tolfenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of tolfenamic acid can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with primidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "thiamylal", "interaction_type": 4, "interaction_text": "The metabolism of thiamylal can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methoxsalen", "interaction_type": 4, "interaction_text": "The metabolism of methoxsalen can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "proguanil", "interaction_type": 4, "interaction_text": "The metabolism of proguanil can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Udenafil", "interaction_type": 4, "interaction_text": "The metabolism of Udenafil can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "alprazolam", "interaction_type": 4, "interaction_text": "The metabolism of alprazolam can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Levobupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Levobupivacaine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bosentan", "interaction_type": 4, "interaction_text": "The metabolism of Bosentan can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "SERATRODAST", "interaction_type": 4, "interaction_text": "The metabolism of SERATRODAST can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Eszopiclone", "interaction_type": 4, "interaction_text": "The metabolism of Eszopiclone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pentamidine", "interaction_type": 4, "interaction_text": "The metabolism of pentamidine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clonazepam", "interaction_type": 4, "interaction_text": "The metabolism of clonazepam can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "SAQUINAVIR", "interaction_type": 4, "interaction_text": "The metabolism of SAQUINAVIR can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "mefenamic acid", "interaction_type": 4, "interaction_text": "The metabolism of mefenamic acid can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "oxybutynin", "interaction_type": 4, "interaction_text": "The metabolism of oxybutynin can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nateglinide", "interaction_type": 4, "interaction_text": "The metabolism of nateglinide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Esomeprazole", "interaction_type": 4, "interaction_text": "The metabolism of Esomeprazole can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "risperidone", "interaction_type": 4, "interaction_text": "The metabolism of risperidone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amiodarone", "interaction_type": 4, "interaction_text": "The metabolism of amiodarone can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bupropion", "interaction_type": 4, "interaction_text": "The metabolism of bupropion can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "PERHEXILINE", "interaction_type": 4, "interaction_text": "The metabolism of PERHEXILINE can be increased when combined with thiamylal.", "severity": 2}
{"drug1": "primidone", "drug2": "cabergoline", "interaction_type": 4, "interaction_text": "The metabolism of cabergoline can be increased when combined with primidone.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Lercanidipine", "interaction_type": 4, "interaction_text": "The metabolism of Lercanidipine can be increased when combined with nafcillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "miconazole", "interaction_type": 4, "interaction_text": "The metabolism of miconazole can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "Ziprasidone", "interaction_type": 4, "interaction_text": "The metabolism of Ziprasidone can be increased when combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nifedipine", "interaction_type": 4, "interaction_text": "The metabolism of nifedipine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "primidone", "drug2": "alclometasone", "interaction_type": 4, "interaction_text": "The metabolism of alclometasone can be increased when combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "RANOLAZINE", "interaction_type": 4, "interaction_text": "The metabolism of RANOLAZINE can be increased when combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ETONOGESTREL", "interaction_type": 4, "interaction_text": "The metabolism of ETONOGESTREL can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Telithromycin", "interaction_type": 4, "interaction_text": "The metabolism of Telithromycin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "TASOSARTAN", "interaction_type": 4, "interaction_text": "The metabolism of TASOSARTAN can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "oxycodone", "interaction_type": 4, "interaction_text": "The metabolism of oxycodone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "SULFAMOXOLE", "interaction_type": 4, "interaction_text": "The metabolism of SULFAMOXOLE can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "buspirone", "interaction_type": 4, "interaction_text": "The metabolism of buspirone can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tamoxifen", "interaction_type": 4, "interaction_text": "The metabolism of tamoxifen can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "galanthamine", "interaction_type": 4, "interaction_text": "The metabolism of galanthamine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "busulfan", "interaction_type": 4, "interaction_text": "The metabolism of busulfan can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cilostazol", "interaction_type": 4, "interaction_text": "The metabolism of cilostazol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ACENOCOUMAROL", "interaction_type": 4, "interaction_text": "The metabolism of ACENOCOUMAROL can be increased when combined with Rifaximin.", "severity": 2}
{"drug1": "primidone", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with primidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "thioridazine", "interaction_type": 4, "interaction_text": "The metabolism of thioridazine can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "PARAMETHADIONE", "interaction_type": 4, "interaction_text": "The metabolism of PARAMETHADIONE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "daunorubicin", "interaction_type": 4, "interaction_text": "The metabolism of daunorubicin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Deutetrabenazine", "interaction_type": 4, "interaction_text": "The metabolism of Deutetrabenazine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amodiaquine", "interaction_type": 4, "interaction_text": "The metabolism of amodiaquine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Alogliptin", "interaction_type": 4, "interaction_text": "The metabolism of Alogliptin can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clofibrate", "interaction_type": 4, "interaction_text": "The metabolism of clofibrate can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "protriptyline", "interaction_type": 4, "interaction_text": "The metabolism of protriptyline can be increased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "eperisone", "interaction_type": 4, "interaction_text": "The metabolism of eperisone can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ruxolitinib", "interaction_type": 4, "interaction_text": "The metabolism of Ruxolitinib can be increased when combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Imidafenacin", "interaction_type": 4, "interaction_text": "The metabolism of Imidafenacin can be increased when combined with primidone.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE DINITRATE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lumiracoxib", "interaction_type": 4, "interaction_text": "The metabolism of Lumiracoxib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nilvadipine", "interaction_type": 4, "interaction_text": "The metabolism of nilvadipine can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "donepezil", "interaction_type": 4, "interaction_text": "The metabolism of donepezil can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tolterodine", "interaction_type": 4, "interaction_text": "The metabolism of tolterodine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Medroxyprogesterone acetate", "interaction_type": 4, "interaction_text": "The metabolism of Medroxyprogesterone acetate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "IVERMECTIN", "interaction_type": 4, "interaction_text": "The metabolism of IVERMECTIN can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ZILEUTON", "interaction_type": 4, "interaction_text": "The metabolism of ZILEUTON can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Torasemide", "interaction_type": 4, "interaction_text": "The metabolism of Torasemide can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "celiprolol", "interaction_type": 4, "interaction_text": "The metabolism of celiprolol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vitamin D3", "interaction_type": 4, "interaction_text": "The metabolism of Vitamin D3 can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ETONOGESTREL", "interaction_type": 4, "interaction_text": "The metabolism of ETONOGESTREL can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ropivacaine", "interaction_type": 4, "interaction_text": "The metabolism of Ropivacaine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "rosiglitazone", "interaction_type": 4, "interaction_text": "The metabolism of rosiglitazone can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "losartan", "interaction_type": 4, "interaction_text": "The metabolism of losartan can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Fluticasone furoate", "interaction_type": 4, "interaction_text": "The metabolism of Fluticasone furoate can be increased when combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "DIHYDROCODEINE", "interaction_type": 4, "interaction_text": "The metabolism of DIHYDROCODEINE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with amobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Olopatadine", "interaction_type": 4, "interaction_text": "The metabolism of Olopatadine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "erythromycin", "interaction_type": 4, "interaction_text": "The metabolism of erythromycin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "indomethacin", "interaction_type": 4, "interaction_text": "The metabolism of indomethacin can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "SAQUINAVIR", "interaction_type": 4, "interaction_text": "The metabolism of SAQUINAVIR can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "xylometazoline", "interaction_type": 4, "interaction_text": "The metabolism of xylometazoline can be increased when combined with thiopental.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Aliskiren", "interaction_type": 4, "interaction_text": "The metabolism of Aliskiren can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sevoflurane", "interaction_type": 4, "interaction_text": "The metabolism of sevoflurane can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sulfinpyrazone", "interaction_type": 4, "interaction_text": "The metabolism of sulfinpyrazone can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nicotine", "interaction_type": 4, "interaction_text": "The metabolism of nicotine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ERGOTAMINE", "interaction_type": 4, "interaction_text": "The metabolism of ERGOTAMINE can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tramadol", "interaction_type": 4, "interaction_text": "The metabolism of Tramadol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "norethindrone", "interaction_type": 4, "interaction_text": "The metabolism of norethindrone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flunisolide", "interaction_type": 4, "interaction_text": "The metabolism of flunisolide can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Linagliptin", "interaction_type": 4, "interaction_text": "The metabolism of Linagliptin can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "amoxapine", "interaction_type": 4, "interaction_text": "The metabolism of amoxapine can be increased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cisapride", "interaction_type": 4, "interaction_text": "The metabolism of cisapride can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Voxilaprevir", "interaction_type": 4, "interaction_text": "The metabolism of Voxilaprevir can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ondansetron", "interaction_type": 4, "interaction_text": "The metabolism of ondansetron can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "niclosamide", "interaction_type": 4, "interaction_text": "The metabolism of niclosamide can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Medroxyprogesterone acetate", "interaction_type": 4, "interaction_text": "The metabolism of Medroxyprogesterone acetate can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cocaine", "interaction_type": 4, "interaction_text": "The metabolism of cocaine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zonisamide", "interaction_type": 4, "interaction_text": "The metabolism of zonisamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "chloroquine", "interaction_type": 4, "interaction_text": "The metabolism of chloroquine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ethylmorphine", "interaction_type": 4, "interaction_text": "The metabolism of Ethylmorphine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zopiclone", "interaction_type": 4, "interaction_text": "The metabolism of zopiclone can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Yohimbine", "interaction_type": 4, "interaction_text": "The metabolism of Yohimbine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Indacaterol", "interaction_type": 4, "interaction_text": "The metabolism of Indacaterol can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Etoricoxib", "interaction_type": 4, "interaction_text": "The metabolism of Etoricoxib can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Rupatadine", "interaction_type": 4, "interaction_text": "The metabolism of Rupatadine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Velpatasvir", "interaction_type": 4, "interaction_text": "The metabolism of Velpatasvir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dasabuvir", "interaction_type": 4, "interaction_text": "The metabolism of Dasabuvir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "estramustine", "interaction_type": 4, "interaction_text": "The metabolism of estramustine can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "enalapril", "interaction_type": 4, "interaction_text": "The metabolism of enalapril can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Posaconazole", "interaction_type": 4, "interaction_text": "The metabolism of Posaconazole can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "haloperidol", "interaction_type": 4, "interaction_text": "The metabolism of haloperidol can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "RUCAPARIB", "interaction_type": 4, "interaction_text": "The metabolism of RUCAPARIB can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "felodipine", "interaction_type": 4, "interaction_text": "The metabolism of felodipine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 4, "interaction_text": "The metabolism of ISOSORBIDE MONONITRATE can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vismodegib", "interaction_type": 4, "interaction_text": "The metabolism of Vismodegib can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "venlafaxine", "interaction_type": 4, "interaction_text": "The metabolism of venlafaxine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fenofibrate", "interaction_type": 4, "interaction_text": "The metabolism of fenofibrate can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 4, "interaction_text": "The metabolism of FLUTICASONE PROPIONATE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "LISURIDE", "interaction_type": 4, "interaction_text": "The metabolism of LISURIDE can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "methoxyflurane", "interaction_type": 4, "interaction_text": "The metabolism of methoxyflurane can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "allylestrenol", "interaction_type": 4, "interaction_text": "The metabolism of allylestrenol can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ketobemidone", "interaction_type": 4, "interaction_text": "The metabolism of Ketobemidone can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 4, "interaction_text": "The metabolism of HYDROXYPROGESTERONE CAPROATE can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Reboxetine", "interaction_type": 4, "interaction_text": "The metabolism of Reboxetine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "METHSUXIMIDE", "interaction_type": 4, "interaction_text": "The metabolism of METHSUXIMIDE can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bicalutamide", "interaction_type": 4, "interaction_text": "The metabolism of bicalutamide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Amrinone", "interaction_type": 4, "interaction_text": "The metabolism of Amrinone can be increased when combined with Mephobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "doxorubicin", "interaction_type": 4, "interaction_text": "The metabolism of doxorubicin can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Midostaurin", "interaction_type": 4, "interaction_text": "The metabolism of Midostaurin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "trimethoprim", "interaction_type": 4, "interaction_text": "The metabolism of trimethoprim can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dutasteride", "interaction_type": 4, "interaction_text": "The metabolism of Dutasteride can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "gliclazide", "interaction_type": 4, "interaction_text": "The metabolism of gliclazide can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "benzphetamine", "interaction_type": 4, "interaction_text": "The metabolism of benzphetamine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nevirapine", "interaction_type": 4, "interaction_text": "The metabolism of nevirapine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "letrozole", "interaction_type": 4, "interaction_text": "The metabolism of letrozole can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Tapentadol", "interaction_type": 4, "interaction_text": "The metabolism of Tapentadol can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "bupivacaine", "interaction_type": 4, "interaction_text": "The metabolism of bupivacaine can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cyclobenzaprine", "interaction_type": 4, "interaction_text": "The metabolism of cyclobenzaprine can be increased when combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flunarizine", "interaction_type": 4, "interaction_text": "The metabolism of flunarizine can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "loperamide", "interaction_type": 4, "interaction_text": "The metabolism of loperamide can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 4, "interaction_text": "The metabolism of Dexchlorpheniramine maleate can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Rosuvastatin", "interaction_type": 4, "interaction_text": "The metabolism of Rosuvastatin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Retapamulin", "interaction_type": 4, "interaction_text": "The metabolism of Retapamulin can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vardenafil", "interaction_type": 4, "interaction_text": "The metabolism of Vardenafil can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nimesulide", "interaction_type": 4, "interaction_text": "The metabolism of nimesulide can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dextromethorphan", "interaction_type": 4, "interaction_text": "The metabolism of dextromethorphan can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "thiotepa", "interaction_type": 4, "interaction_text": "The metabolism of thiotepa can be increased when combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mestranol", "interaction_type": 4, "interaction_text": "The metabolism of mestranol can be increased when combined with Rifampicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "PHENPROCOUMON", "interaction_type": 4, "interaction_text": "The metabolism of PHENPROCOUMON can be increased when combined with thiopental.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "albendazole", "interaction_type": 4, "interaction_text": "The metabolism of albendazole can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nicardipine", "interaction_type": 4, "interaction_text": "The metabolism of nicardipine can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Elbasvir", "interaction_type": 4, "interaction_text": "The metabolism of Elbasvir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Grazoprevir", "interaction_type": 4, "interaction_text": "The metabolism of Grazoprevir can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Quinine", "interaction_type": 4, "interaction_text": "The metabolism of Quinine can be increased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lenvatinib", "interaction_type": 4, "interaction_text": "The metabolism of Lenvatinib can be increased when combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nitrendipine", "interaction_type": 4, "interaction_text": "The metabolism of nitrendipine can be increased when combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "cinnarizine", "interaction_type": 4, "interaction_text": "The metabolism of cinnarizine can be increased when combined with Aprepitant.", "severity": 2}
{"drug1": "nevirapine", "drug2": "theophylline", "interaction_type": 4, "interaction_text": "The metabolism of theophylline can be increased when combined with nevirapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "mycophenolate mofetil", "interaction_type": 4, "interaction_text": "The metabolism of mycophenolate mofetil can be increased when combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "alfuzosin", "interaction_type": 4, "interaction_text": "The metabolism of alfuzosin can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "prochlorperazine", "interaction_type": 4, "interaction_text": "The metabolism of prochlorperazine can be increased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "droxidopa", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of droxidopa.", "severity": 2}
{"drug1": "spironolactone", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ERGOTAMINE", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "naphazoline", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of naphazoline.", "severity": 2}
{"drug1": "terazosin", "drug2": "Mirabegron", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of Mirabegron.", "severity": 2}
{"drug1": "Silodosin", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "brimonidine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of brimonidine.", "severity": 2}
{"drug1": "prazosin", "drug2": "dipivefrin", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of dipivefrin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "terazosin", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "terazosin", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "terazosin", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "terazosin", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "clonidine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of clonidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "naphazoline", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of naphazoline.", "severity": 2}
{"drug1": "terazosin", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "midodrine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of midodrine.", "severity": 2}
{"drug1": "terazosin", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "methyldopa", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of methyldopa.", "severity": 2}
{"drug1": "spironolactone", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "terazosin", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "prazosin", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "apraclonidine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of apraclonidine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "prazosin", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "terazosin", "drug2": "oxymetazoline", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of oxymetazoline.", "severity": 2}
{"drug1": "doxazosin", "drug2": "norepinephrine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of norepinephrine.", "severity": 2}
{"drug1": "prazosin", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "terazosin", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "terazosin", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "labetalol", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "spironolactone", "drug2": "naphazoline", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of naphazoline.", "severity": 2}
{"drug1": "Silodosin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "terazosin", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "prazosin", "drug2": "Mirabegron", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of Mirabegron.", "severity": 2}
{"drug1": "spironolactone", "drug2": "brimonidine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of brimonidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "droxidopa", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of droxidopa.", "severity": 2}
{"drug1": "carvedilol", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "spironolactone", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "prazosin", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "prazosin", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "midodrine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of midodrine.", "severity": 2}
{"drug1": "prazosin", "drug2": "midodrine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of midodrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "dipivefrin", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of dipivefrin.", "severity": 2}
{"drug1": "prazosin", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "dipivefrin", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of dipivefrin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "midodrine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of midodrine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "terazosin", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "tizanidine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of tizanidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ERGOTAMINE", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "carvedilol", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Nebivolol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of Nebivolol.", "severity": 2}
{"drug1": "terazosin", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "labetalol", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "labetalol", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "terazosin", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "naphazoline", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of naphazoline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "droxidopa", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of droxidopa.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "labetalol", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "dipivefrin", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of dipivefrin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "terazosin", "drug2": "norepinephrine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of norepinephrine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "terazosin", "drug2": "guanabenz", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of guanabenz.", "severity": 2}
{"drug1": "prazosin", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "terazosin", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "Silodosin", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "terazosin", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "terazosin", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Mirabegron", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of Mirabegron.", "severity": 2}
{"drug1": "Silodosin", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ERGOTAMINE", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "spironolactone", "drug2": "midodrine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of midodrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "prazosin", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "labetalol", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "prazosin", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "prazosin", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "apraclonidine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of apraclonidine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "spironolactone", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "guanabenz", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of guanabenz.", "severity": 2}
{"drug1": "terazosin", "drug2": "ERGOTAMINE", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "apraclonidine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of apraclonidine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "prazosin", "drug2": "oxymetazoline", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of oxymetazoline.", "severity": 2}
{"drug1": "terazosin", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "isoxsuprine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of isoxsuprine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "prazosin", "drug2": "norepinephrine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of norepinephrine.", "severity": 2}
{"drug1": "prazosin", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "terazosin", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "dipivefrin", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of dipivefrin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "midodrine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of midodrine.", "severity": 2}
{"drug1": "prazosin", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Mirabegron", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of Mirabegron.", "severity": 2}
{"drug1": "labetalol", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "droxidopa", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of droxidopa.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "norepinephrine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of norepinephrine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "terazosin", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "labetalol", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "terazosin", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "tizanidine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of tizanidine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Mirabegron", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of Mirabegron.", "severity": 2}
{"drug1": "spironolactone", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "oxymetazoline", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of oxymetazoline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "prazosin", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "terazosin", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "MEPHENTERMINE", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "Silodosin", "drug2": "norepinephrine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of norepinephrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "terazosin", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "Silodosin", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "labetalol", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "tizanidine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of tizanidine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "droxidopa", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of droxidopa.", "severity": 2}
{"drug1": "terazosin", "drug2": "clenbuterol", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of clenbuterol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "isoxsuprine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of isoxsuprine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "prazosin", "drug2": "naphazoline", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of naphazoline.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Lofexidine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of Lofexidine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "guanabenz", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of guanabenz.", "severity": 2}
{"drug1": "prazosin", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "oxymetazoline", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of oxymetazoline.", "severity": 2}
{"drug1": "prazosin", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "terazosin", "drug2": "midodrine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of midodrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "oxymetazoline", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of oxymetazoline.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "norepinephrine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of norepinephrine.", "severity": 2}
{"drug1": "labetalol", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "terazosin", "drug2": "naphazoline", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of naphazoline.", "severity": 2}
{"drug1": "terazosin", "drug2": "dipivefrin", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of dipivefrin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "terazosin", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "PROCATEROL", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of PROCATEROL.", "severity": 2}
{"drug1": "carvedilol", "drug2": "epinastine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of epinastine.", "severity": 2}
{"drug1": "terazosin", "drug2": "droxidopa", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of droxidopa.", "severity": 2}
{"drug1": "prazosin", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "guanabenz", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of guanabenz.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "dipivefrin", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of dipivefrin.", "severity": 2}
{"drug1": "prazosin", "drug2": "formoterol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of formoterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "labetalol", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "GUANFACINE", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of GUANFACINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "ritodrine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of ritodrine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "oxymetazoline", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of oxymetazoline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "PIRBUTEROL", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of PIRBUTEROL.", "severity": 2}
{"drug1": "prazosin", "drug2": "droxidopa", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of droxidopa.", "severity": 2}
{"drug1": "Silodosin", "drug2": "clonidine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of clonidine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ERGOTAMINE", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "methoxamine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of methoxamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "norepinephrine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of norepinephrine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Ephedrine", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of Ephedrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "prazosin", "drug2": "isoetharine", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of isoetharine.", "severity": 2}
{"drug1": "terazosin", "drug2": "OLODATEROL", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of OLODATEROL.", "severity": 2}
{"drug1": "spironolactone", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Salmeterol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of Salmeterol.", "severity": 2}
{"drug1": "promethazine", "drug2": "epinephrine", "interaction_type": 5, "interaction_text": "promethazine may decrease the vasoconstricting activities of epinephrine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "metaproterenol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of metaproterenol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "GUANFACINE", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of GUANFACINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "oxymetazoline", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of oxymetazoline.", "severity": 2}
{"drug1": "prazosin", "drug2": "isoproterenol", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of isoproterenol.", "severity": 2}
{"drug1": "prazosin", "drug2": "ERGOTAMINE", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "doxazosin may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "isoxsuprine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of isoxsuprine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Arformoterol", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of Arformoterol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "phenylephrine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of phenylephrine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Salbutamol", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of Salbutamol.", "severity": 2}
{"drug1": "prazosin", "drug2": "terbutaline", "interaction_type": 5, "interaction_text": "prazosin may decrease the vasoconstricting activities of terbutaline.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Lofexidine", "interaction_type": 5, "interaction_text": "Silodosin may decrease the vasoconstricting activities of Lofexidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "alfuzosin may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "labetalol", "drug2": "HEXOPRENALINE", "interaction_type": 5, "interaction_text": "labetalol may decrease the vasoconstricting activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nylidrin", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of nylidrin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ARBUTAMINE", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of ARBUTAMINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "metaraminol", "interaction_type": 5, "interaction_text": "carvedilol may decrease the vasoconstricting activities of metaraminol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "naphazoline", "interaction_type": 5, "interaction_text": "TAMSULOSIN may decrease the vasoconstricting activities of naphazoline.", "severity": 2}
{"drug1": "terazosin", "drug2": "phenylpropanolamine", "interaction_type": 5, "interaction_text": "terazosin may decrease the vasoconstricting activities of phenylpropanolamine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "methyldopa", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of methyldopa.", "severity": 2}
{"drug1": "spironolactone", "drug2": "dobutamine", "interaction_type": 5, "interaction_text": "spironolactone may decrease the vasoconstricting activities of dobutamine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "warfarin", "drug2": "amiodarone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of amiodarone.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "warfarin", "drug2": "cyclobenzaprine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cyclobenzaprine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "chlorpropamide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of chlorpropamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "CEFIXIME", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of CEFIXIME.", "severity": 2}
{"drug1": "warfarin", "drug2": "glucosamine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of glucosamine.", "severity": 2}
{"drug1": "argatroban", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tamoxifen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tamoxifen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "argatroban", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "amiodarone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of amiodarone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "MEZLOCILLIN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of MEZLOCILLIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefuroxime", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefuroxime.", "severity": 2}
{"drug1": "EDTA", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "warfarin", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "etoposide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of etoposide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "atorvastatin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of atorvastatin.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "EDTA", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "phenindione", "drug2": "phenytoin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of phenytoin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "phenindione", "drug2": "doxycycline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of doxycycline.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefuroxime", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefuroxime.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "mirtazapine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of mirtazapine.", "severity": 2}
{"drug1": "warfarin", "drug2": "sparfloxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of sparfloxacin.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "warfarin", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "Ditazole", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "EDTA", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "oxymetholone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of oxymetholone.", "severity": 2}
{"drug1": "phenindione", "drug2": "cyclobenzaprine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cyclobenzaprine.", "severity": 2}
{"drug1": "phenindione", "drug2": "CEFORANIDE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of CEFORANIDE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "tirofiban", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "mirtazapine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of mirtazapine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sparfloxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of sparfloxacin.", "severity": 2}
{"drug1": "argatroban", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Gliquidone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Gliquidone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "EDTA", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of EDTA.", "severity": 2}
{"drug1": "Triflusal", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "citric acid", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "EDTA", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "EDTA", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "EDTA", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "phenindione", "drug2": "ROSOXACIN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ROSOXACIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Ceftobiprole", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Ceftobiprole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "citric acid", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "argatroban", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "warfarin", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "warfarin", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Rosuvastatin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Rosuvastatin.", "severity": 2}
{"drug1": "phenindione", "drug2": "Dothiepin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Dothiepin.", "severity": 2}
{"drug1": "citric acid", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "amitriptyline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of amitriptyline.", "severity": 2}
{"drug1": "warfarin", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "phenindione", "drug2": "fenofibrate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fenofibrate.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "warfarin", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "phenindione", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "phenindione", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "argatroban", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "argatroban", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "argatroban", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "EDTA", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "dicumarol", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "citric acid", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "nimesulide may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ampicillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ampicillin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "VERAPAMIL", "interaction_type": 6, "interaction_text": "TROLAMINE SALICYLATE may increase the anticoagulant activities of VERAPAMIL.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "warfarin", "drug2": "cephalexin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cephalexin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "warfarin", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "argatroban", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "warfarin", "drug2": "RIMEXOLONE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of RIMEXOLONE.", "severity": 2}
{"drug1": "warfarin", "drug2": "liothyronine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of liothyronine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "phenindione", "drug2": "cephalexin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cephalexin.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "CEFIXIME", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of CEFIXIME.", "severity": 2}
{"drug1": "warfarin", "drug2": "ampicillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ampicillin.", "severity": 2}
{"drug1": "warfarin", "drug2": "penicillin v", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of penicillin v.", "severity": 2}
{"drug1": "warfarin", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "dicumarol", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "VERAPAMIL", "interaction_type": 6, "interaction_text": "mesalamine may increase the anticoagulant activities of VERAPAMIL.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "amoxicillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of amoxicillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Pitavastatin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Pitavastatin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefmetazole", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefmetazole.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cephalexin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cephalexin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "EDTA", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "tirofiban", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "warfarin", "drug2": "Vorinostat", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Vorinostat.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "tirofiban", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "citric acid", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "citric acid", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Tianeptine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Tianeptine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Liotrix", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Liotrix.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "EDTA", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "NANDROLONE DECANOATE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "citric acid", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "chloramphenicol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of chloramphenicol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "SULBACTAM", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of SULBACTAM.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "phenindione", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "bezafibrate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of bezafibrate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "EDTA", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "Ditazole", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "CYCLACILLIN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of CYCLACILLIN.", "severity": 2}
{"drug1": "warfarin", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "warfarin", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "testosterone propionate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of testosterone propionate.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "warfarin", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "citric acid", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "EDTA", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "TROLAMINE SALICYLATE may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "oxacillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of oxacillin.", "severity": 2}
{"drug1": "phenindione", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "warfarin", "drug2": "halcinonide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of halcinonide.", "severity": 2}
{"drug1": "phenindione", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "difluprednate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of difluprednate.", "severity": 2}
{"drug1": "warfarin", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "citric acid", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "citric acid", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Dabigatran etexilate", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Dabigatran etexilate.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ampicillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ampicillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "penicillin v", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of penicillin v.", "severity": 2}
{"drug1": "anagrelide", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "CEFPODOXIME", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of CEFPODOXIME.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Cefacetrile", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Cefacetrile.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "stanozolol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of stanozolol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "norfloxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of norfloxacin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cephapirin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cephapirin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "phenindione", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "Apixaban", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "phenindione", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cephalexin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cephalexin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "citric acid", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "warfarin", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "warfarin", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "phenindione", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "aspirin may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "phenindione", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "EDTA", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "phenindione", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "phenindione", "drug2": "ethotoin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ethotoin.", "severity": 2}
{"drug1": "phenindione", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "dicumarol", "drug2": "amiodarone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of amiodarone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Escitalopram", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Escitalopram.", "severity": 2}
{"drug1": "warfarin", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "argatroban", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "argatroban", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Ximelagatran", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Ximelagatran.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "pravastatin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of pravastatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cyclobenzaprine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cyclobenzaprine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "argatroban", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "dicumarol", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "citric acid", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "EDTA", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "etoposide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of etoposide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "dicumarol", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "cilostazol", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "phenindione", "drug2": "danazol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of danazol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "phenindione", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "warfarin", "drug2": "methylprednisolone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of methylprednisolone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefmetazole", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefmetazole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "liothyronine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of liothyronine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "IVERMECTIN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of IVERMECTIN.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "phenindione", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "EDTA", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "Ditazole", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "tirofiban", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "Apixaban", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "duloxetine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of duloxetine.", "severity": 2}
{"drug1": "citric acid", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fluoxetine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of fluoxetine.", "severity": 2}
{"drug1": "argatroban", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "chloramphenicol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of chloramphenicol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "Escitalopram", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Escitalopram.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefaclor", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefaclor.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cinoxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cinoxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Escitalopram", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Escitalopram.", "severity": 2}
{"drug1": "dicumarol", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "EDTA", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "phenindione", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "EDTA", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sulfamethoxazole", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of sulfamethoxazole.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "glyburide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of glyburide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "minocycline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of minocycline.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Cefacetrile", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Cefacetrile.", "severity": 2}
{"drug1": "warfarin", "drug2": "piperacillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of piperacillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "CEFPODOXIME", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of CEFPODOXIME.", "severity": 2}
{"drug1": "phenindione", "drug2": "sulfamethoxazole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sulfamethoxazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "EDTA", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "warfarin", "drug2": "acetaminophen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of acetaminophen.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "EDTA", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "EDTA", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "trimipramine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of trimipramine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "piperacillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of piperacillin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "quinidine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of quinidine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Gefitinib", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Gefitinib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "acetaminophen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of acetaminophen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "phenindione", "drug2": "protriptyline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of protriptyline.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of PENTAERYTHRITOL TETRANITRATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "bezafibrate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of bezafibrate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "danazol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of danazol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "warfarin", "drug2": "diflorasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of diflorasone.", "severity": 2}
{"drug1": "warfarin", "drug2": "glimepiride", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of glimepiride.", "severity": 2}
{"drug1": "warfarin", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "epoprostenol may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefotiam", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefotiam.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Tazobactam", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Tazobactam.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "argatroban", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "EDTA", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "glimepiride", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of glimepiride.", "severity": 2}
{"drug1": "citric acid", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "phenindione", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "citric acid", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "phenindione", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "Apixaban", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "ifosfamide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ifosfamide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "fluoxymesterone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fluoxymesterone.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "cilostazol", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "dicumarol", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "danazol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of danazol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Fenofibric acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Fenofibric acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "L-carnitine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of L-carnitine.", "severity": 2}
{"drug1": "EDTA", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "chlortetracycline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of chlortetracycline.", "severity": 2}
{"drug1": "warfarin", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "warfarin", "drug2": "proguanil", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of proguanil.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "diltiazem", "interaction_type": 6, "interaction_text": "BALSALAZIDE may increase the anticoagulant activities of diltiazem.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "dicumarol", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fluoxymesterone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of fluoxymesterone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ifosfamide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ifosfamide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "EDTA", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of EDTA.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "phenindione", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "argatroban", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "citric acid", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "warfarin", "drug2": "amoxapine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of amoxapine.", "severity": 2}
{"drug1": "warfarin", "drug2": "nortriptyline", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of nortriptyline.", "severity": 2}
{"drug1": "warfarin", "drug2": "desoximetasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of desoximetasone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "citric acid", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "citric acid", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "citric acid", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Vorinostat", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Vorinostat.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "EDTA", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "ceftazidime", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ceftazidime.", "severity": 2}
{"drug1": "citric acid", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Cefacetrile", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Cefacetrile.", "severity": 2}
{"drug1": "warfarin", "drug2": "allopurinol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of allopurinol.", "severity": 2}
{"drug1": "phenindione", "drug2": "CEFPODOXIME", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of CEFPODOXIME.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "MEZLOCILLIN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of MEZLOCILLIN.", "severity": 2}
{"drug1": "warfarin", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "dicumarol", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefmenoxime", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefmenoxime.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "L-carnitine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of L-carnitine.", "severity": 2}
{"drug1": "argatroban", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Fenofibric acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Fenofibric acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "protriptyline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of protriptyline.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "anagrelide", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Triflusal", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "argatroban", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "EDTA", "drug2": "Dabigatran etexilate", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Dabigatran etexilate.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "demeclocycline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of demeclocycline.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cephapirin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cephapirin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "Ditazole", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "warfarin", "drug2": "Tazobactam", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Tazobactam.", "severity": 2}
{"drug1": "dicumarol", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "quinidine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of quinidine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "phenindione", "drug2": "OXANDROLONE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of OXANDROLONE.", "severity": 2}
{"drug1": "phenindione", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "enoxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of enoxacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Quinine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Quinine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefadroxil", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefadroxil.", "severity": 2}
{"drug1": "Apixaban", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "warfarin", "drug2": "doxepin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of doxepin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cyclobenzaprine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cyclobenzaprine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Rosuvastatin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Rosuvastatin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "Ditazole", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "phenindione", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "cinoxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cinoxacin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Pefloxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Pefloxacin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefadroxil", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefadroxil.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "doxepin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of doxepin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefaclor", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefaclor.", "severity": 2}
{"drug1": "citric acid", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "EDTA", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Pivmecillinam", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Pivmecillinam.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Pivampicillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Pivampicillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "TICARCILLIN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of TICARCILLIN.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "methicillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of methicillin.", "severity": 2}
{"drug1": "argatroban", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "Rosuvastatin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Rosuvastatin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "anagrelide", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "diltiazem", "interaction_type": 6, "interaction_text": "Olsalazine may increase the anticoagulant activities of diltiazem.", "severity": 2}
{"drug1": "EDTA", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "MEZLOCILLIN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of MEZLOCILLIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "phenindione", "drug2": "sulfadiazine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sulfadiazine.", "severity": 2}
{"drug1": "warfarin", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefoperazone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefoperazone.", "severity": 2}
{"drug1": "warfarin", "drug2": "CEFONICID", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CEFONICID.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefazolin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefazolin.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefamandole", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefamandole.", "severity": 2}
{"drug1": "warfarin", "drug2": "Fosphenytoin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Fosphenytoin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefotiam", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefotiam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nortriptyline", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of nortriptyline.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefoperazone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefoperazone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "CEFONICID", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of CEFONICID.", "severity": 2}
{"drug1": "citric acid", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "phenindione", "drug2": "glimepiride", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of glimepiride.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefamandole", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefamandole.", "severity": 2}
{"drug1": "citric acid", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Fosphenytoin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Fosphenytoin.", "severity": 2}
{"drug1": "phenindione", "drug2": "lovastatin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of lovastatin.", "severity": 2}
{"drug1": "phenindione", "drug2": "Escitalopram", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Escitalopram.", "severity": 2}
{"drug1": "phenindione", "drug2": "pravastatin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of pravastatin.", "severity": 2}
{"drug1": "phenindione", "drug2": "fluvoxamine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fluvoxamine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "phenindione", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "warfarin", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "diflunisal", "drug2": "VERAPAMIL", "interaction_type": 6, "interaction_text": "diflunisal may increase the anticoagulant activities of VERAPAMIL.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ceftazidime", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ceftazidime.", "severity": 2}
{"drug1": "warfarin", "drug2": "chlortetracycline", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of chlortetracycline.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "allopurinol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of allopurinol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Tixocortol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Tixocortol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Ceftobiprole", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Ceftobiprole.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "phenindione", "drug2": "etoposide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of etoposide.", "severity": 2}
{"drug1": "phenindione", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "phenindione", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "phenindione", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "phenindione", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "warfarin", "drug2": "paramethasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of paramethasone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Liotrix", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Liotrix.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "phenindione", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "phenindione", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "phenindione", "drug2": "Trovafloxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Trovafloxacin.", "severity": 2}
{"drug1": "warfarin", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "phenindione", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "phenindione", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "argatroban", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "Ditazole", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "citric acid", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "argatroban", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "citric acid", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "cilostazol", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "dicumarol", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "EDTA", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "warfarin", "drug2": "CYCLACILLIN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CYCLACILLIN.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "citric acid", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "warfarin", "drug2": "betamethasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of betamethasone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ROSOXACIN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ROSOXACIN.", "severity": 2}
{"drug1": "warfarin", "drug2": "chloramphenicol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of chloramphenicol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "warfarin", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "warfarin", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "warfarin", "drug2": "Trovafloxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Trovafloxacin.", "severity": 2}
{"drug1": "citric acid", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "warfarin", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "warfarin", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "argatroban", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "citric acid", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "citric acid", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "phenytoin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of phenytoin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "citric acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of citric acid.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "OXANDROLONE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of OXANDROLONE.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "testosterone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of testosterone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cyclobenzaprine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cyclobenzaprine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "CEFORANIDE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of CEFORANIDE.", "severity": 2}
{"drug1": "argatroban", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ACENOCOUMAROL", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ACENOCOUMAROL.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "citric acid", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "citric acid", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "warfarin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "citric acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of citric acid.", "severity": 2}
{"drug1": "tirofiban", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "citric acid", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "simvastatin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of simvastatin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "dicumarol", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "EDTA", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "citric acid", "drug2": "Dabigatran etexilate", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Dabigatran etexilate.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "desipramine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of desipramine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "Gemifloxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Gemifloxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Ceftobiprole", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Ceftobiprole.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "warfarin", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Apixaban", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "warfarin", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "desipramine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of desipramine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Gemifloxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Gemifloxacin.", "severity": 2}
{"drug1": "argatroban", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "warfarin", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "dicumarol", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "tirofiban", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "EDTA", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of EDTA.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "EDTA", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "EDTA", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Ximelagatran", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Ximelagatran.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "warfarin", "drug2": "orlistat", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of orlistat.", "severity": 2}
{"drug1": "Apixaban", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "warfarin", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Dabigatran etexilate", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Dabigatran etexilate.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "EDTA", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "phenindione", "drug2": "mirtazapine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of mirtazapine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "oxymetholone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of oxymetholone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "warfarin", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Trovafloxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Trovafloxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "warfarin", "drug2": "ceftizoxime", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ceftizoxime.", "severity": 2}
{"drug1": "warfarin", "drug2": "cephradine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cephradine.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefotetan", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefotetan.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefoxitin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefoxitin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "Ceftobiprole", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Ceftobiprole.", "severity": 2}
{"drug1": "phenindione", "drug2": "citalopram", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of citalopram.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "phenindione", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ceftizoxime", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ceftizoxime.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cephradine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cephradine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefotetan", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefotetan.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefoxitin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefoxitin.", "severity": 2}
{"drug1": "EDTA", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "phenindione", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ceftriaxone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ceftriaxone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "clomipramine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of clomipramine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "warfarin", "drug2": "testosterone propionate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of testosterone propionate.", "severity": 2}
{"drug1": "argatroban", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "warfarin", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "chloramphenicol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of chloramphenicol.", "severity": 2}
{"drug1": "phenindione", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "warfarin", "drug2": "Pitavastatin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Pitavastatin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "phenindione", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "phenindione", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "phenindione", "drug2": "Rosuvastatin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Rosuvastatin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "phenindione", "drug2": "amoxapine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of amoxapine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Fosphenytoin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Fosphenytoin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefamandole", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefamandole.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefoperazone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefoperazone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "CEFONICID", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of CEFONICID.", "severity": 2}
{"drug1": "dicumarol", "drug2": "oxymetholone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of oxymetholone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "warfarin", "drug2": "etoposide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of etoposide.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "phenindione", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cephradine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cephradine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "bacampicillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of bacampicillin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fenofibrate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of fenofibrate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "citric acid", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Ximelagatran", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Ximelagatran.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Ditazole", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "dicumarol", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "warfarin", "drug2": "imipramine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of imipramine.", "severity": 2}
{"drug1": "phenindione", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "warfarin", "drug2": "L-thyroxine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of L-thyroxine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "warfarin", "drug2": "cephalothin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cephalothin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "ethyl icosapentate may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "argatroban", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "CEFORANIDE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CEFORANIDE.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "warfarin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "citric acid", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "citric acid", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "argatroban", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "dicumarol", "drug2": "clofibrate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of clofibrate.", "severity": 2}
{"drug1": "argatroban", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "argatroban", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "argatroban", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "dicumarol", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "argatroban", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "citric acid", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "warfarin", "drug2": "L-carnitine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of L-carnitine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "warfarin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Ditazole", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "citric acid", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "dicumarol", "drug2": "doxycycline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of doxycycline.", "severity": 2}
{"drug1": "dicumarol", "drug2": "CEFORANIDE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of CEFORANIDE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "phenytoin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of phenytoin.", "severity": 2}
{"drug1": "citric acid", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "EDTA", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "CEFONICID", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of CEFONICID.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "tirofiban", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "dicumarol", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "EDTA", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "Ditazole", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ROSOXACIN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ROSOXACIN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "warfarin", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "milrinone", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "milrinone may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "Ditazole", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "EDTA", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "warfarin", "drug2": "amitriptyline", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of amitriptyline.", "severity": 2}
{"drug1": "EDTA", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ifosfamide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ifosfamide.", "severity": 2}
{"drug1": "warfarin", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fluoxymesterone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of fluoxymesterone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ethotoin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ethotoin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "phenindione", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "citalopram", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of citalopram.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "amitriptyline", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of amitriptyline.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "EDTA", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "EDTA", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "EDTA", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "EDTA", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "warfarin", "drug2": "SULBACTAM", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of SULBACTAM.", "severity": 2}
{"drug1": "EDTA", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "warfarin", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Penicillin G benzathine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Penicillin G benzathine.", "severity": 2}
{"drug1": "EDTA", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "warfarin", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "CEFORANIDE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of CEFORANIDE.", "severity": 2}
{"drug1": "EDTA", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "EDTA", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "warfarin", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "phenindione", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "NANDROLONE DECANOATE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "chlortetracycline", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of chlortetracycline.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "warfarin", "drug2": "ifosfamide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ifosfamide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "argatroban", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "warfarin", "drug2": "fluoxymesterone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of fluoxymesterone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "phenindione", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "phenindione", "drug2": "desipramine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of desipramine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "phenindione", "drug2": "Gemifloxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Gemifloxacin.", "severity": 2}
{"drug1": "phenindione", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "L-carnitine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of L-carnitine.", "severity": 2}
{"drug1": "citric acid", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "danazol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of danazol.", "severity": 2}
{"drug1": "aspirin", "drug2": "diltiazem", "interaction_type": 6, "interaction_text": "aspirin may increase the anticoagulant activities of diltiazem.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sparfloxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of sparfloxacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "imipramine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of imipramine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "L-thyroxine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of L-thyroxine.", "severity": 2}
{"drug1": "phenindione", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cephalothin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cephalothin.", "severity": 2}
{"drug1": "Ditazole", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "phenindione", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "argatroban", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "EDTA", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Penicillin G benzathine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Penicillin G benzathine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "SULBACTAM", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of SULBACTAM.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefotetan", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefotetan.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefoxitin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefoxitin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ceftizoxime", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ceftizoxime.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "phenindione", "drug2": "oxymetholone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of oxymetholone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "phenindione", "drug2": "ceftizoxime", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ceftizoxime.", "severity": 2}
{"drug1": "warfarin", "drug2": "Fluticasone furoate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Fluticasone furoate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "warfarin", "drug2": "formestane", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of formestane.", "severity": 2}
{"drug1": "phenindione", "drug2": "sparfloxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sparfloxacin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "argatroban", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "citric acid", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "citric acid", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "amoxapine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of amoxapine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Tianeptine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Tianeptine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefoxitin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefoxitin.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefotetan", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefotetan.", "severity": 2}
{"drug1": "phenindione", "drug2": "cephradine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cephradine.", "severity": 2}
{"drug1": "EDTA", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "EDTA", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "warfarin", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "warfarin", "drug2": "enoxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of enoxacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefaclor", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefaclor.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tolazamide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tolazamide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefazolin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefazolin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "phenindione", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "flumethasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of flumethasone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "citric acid", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "warfarin", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "piperacillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of piperacillin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "Triflusal", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "simvastatin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of simvastatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "acetaminophen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of acetaminophen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Pefloxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Pefloxacin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "VERAPAMIL", "interaction_type": 6, "interaction_text": "Olsalazine may increase the anticoagulant activities of VERAPAMIL.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "warfarin", "drug2": "Quinine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Quinine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ceftriaxone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ceftriaxone.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "citric acid", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "protriptyline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of protriptyline.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "dicumarol", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefmenoxime", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefmenoxime.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "warfarin", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "Apixaban", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ifosfamide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ifosfamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fluoxymesterone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of fluoxymesterone.", "severity": 2}
{"drug1": "warfarin", "drug2": "cephaloridine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cephaloridine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "argatroban", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Clobetasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Clobetasone.", "severity": 2}
{"drug1": "Triflusal", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "Triflusal", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "epinastine", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "epinastine may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "L-carnitine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of L-carnitine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "EDTA", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cephalexin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cephalexin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "phenindione", "drug2": "MEZLOCILLIN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of MEZLOCILLIN.", "severity": 2}
{"drug1": "phenindione", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "citric acid", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "EDTA", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "citric acid", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "citric acid", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "citric acid", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "stanozolol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of stanozolol.", "severity": 2}
{"drug1": "phenindione", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "warfarin", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefmenoxime", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefmenoxime.", "severity": 2}
{"drug1": "warfarin", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Rosuvastatin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Rosuvastatin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "Apixaban", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "EDTA", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "EDTA", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefmenoxime", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefmenoxime.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "phenindione", "drug2": "Penicillin G benzathine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Penicillin G benzathine.", "severity": 2}
{"drug1": "phenindione", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "phenindione", "drug2": "SULBACTAM", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of SULBACTAM.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "EDTA", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Gefitinib", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Gefitinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "penicillin v", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of penicillin v.", "severity": 2}
{"drug1": "phenindione", "drug2": "ampicillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ampicillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "phenindione", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "phenindione", "drug2": "Etofibrate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Etofibrate.", "severity": 2}
{"drug1": "phenindione", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "CEFPODOXIME", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of CEFPODOXIME.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "warfarin", "drug2": "fleroxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of fleroxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "enoxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of enoxacin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Estrone sulfate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Estrone sulfate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "phenindione", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "phenindione", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Quinine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Quinine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "warfarin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "paroxetine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of paroxetine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "oxacillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of oxacillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "nalidixic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of nalidixic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "phenindione", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Pefloxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Pefloxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "argatroban", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "phenindione", "drug2": "nefazodone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of nefazodone.", "severity": 2}
{"drug1": "phenindione", "drug2": "doxepin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of doxepin.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefadroxil", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefadroxil.", "severity": 2}
{"drug1": "EDTA", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "phenindione", "drug2": "clofibrate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of clofibrate.", "severity": 2}
{"drug1": "citric acid", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "warfarin", "drug2": "paroxetine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of paroxetine.", "severity": 2}
{"drug1": "argatroban", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sulfamethoxazole", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of sulfamethoxazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "minocycline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of minocycline.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefoperazone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefoperazone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "quinidine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of quinidine.", "severity": 2}
{"drug1": "phenindione", "drug2": "Fosphenytoin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Fosphenytoin.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefamandole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefamandole.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefazolin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefazolin.", "severity": 2}
{"drug1": "EDTA", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "citric acid", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "citric acid", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "duloxetine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of duloxetine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cinoxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cinoxacin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "warfarin", "drug2": "tamoxifen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tamoxifen.", "severity": 2}
{"drug1": "warfarin", "drug2": "CEFIXIME", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CEFIXIME.", "severity": 2}
{"drug1": "warfarin", "drug2": "chlorpropamide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of chlorpropamide.", "severity": 2}
{"drug1": "warfarin", "drug2": "quinidine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of quinidine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "citric acid", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "citric acid", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "citric acid", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefotaxime", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefotaxime.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "phenindione", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "warfarin", "drug2": "loteprednol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of loteprednol.", "severity": 2}
{"drug1": "warfarin", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "penicillin g", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of penicillin g.", "severity": 2}
{"drug1": "EDTA", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "citric acid", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "EDTA", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "cilostazol", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "Ditazole", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fleroxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of fleroxacin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefmetazole", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefmetazole.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "paroxetine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of paroxetine.", "severity": 2}
{"drug1": "EDTA", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "Ditazole", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "liothyronine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of liothyronine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "stanozolol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of stanozolol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefotiam", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefotiam.", "severity": 2}
{"drug1": "warfarin", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "tirofiban", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "phenindione", "drug2": "Vorinostat", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Vorinostat.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "glimepiride", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of glimepiride.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefotaxime", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefotaxime.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "pravastatin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of pravastatin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "Apixaban", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Rivaroxaban", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Rivaroxaban.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "citric acid", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nalidixic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of nalidixic acid.", "severity": 2}
{"drug1": "EDTA", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "EDTA", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "warfarin", "drug2": "norfloxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of norfloxacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "phenindione", "drug2": "norfloxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of norfloxacin.", "severity": 2}
{"drug1": "argatroban", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "penicillin g", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of penicillin g.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Trovafloxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Trovafloxacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "norfloxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of norfloxacin.", "severity": 2}
{"drug1": "warfarin", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tamoxifen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tamoxifen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "EDTA", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "chlorpropamide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of chlorpropamide.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of PENTAERYTHRITOL TETRANITRATE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "quinidine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of quinidine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "methyltestosterone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of methyltestosterone.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "EDTA", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of EDTA.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "liothyronine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of liothyronine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Penicillin G benzathine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Penicillin G benzathine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefmetazole", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefmetazole.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "oxymetholone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of oxymetholone.", "severity": 2}
{"drug1": "EDTA", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "dicumarol", "drug2": "bezafibrate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of bezafibrate.", "severity": 2}
{"drug1": "phenindione", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "testosterone propionate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of testosterone propionate.", "severity": 2}
{"drug1": "tirofiban", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "EDTA", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "argatroban", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "citric acid", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "phenindione", "drug2": "piperacillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of piperacillin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "duloxetine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of duloxetine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Gliquidone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Gliquidone.", "severity": 2}
{"drug1": "phenindione", "drug2": "acetaminophen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of acetaminophen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Gefitinib", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Gefitinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "Gatifloxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Gatifloxacin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "warfarin", "drug2": "Pefloxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Pefloxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "ticlopidine may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "phenindione", "drug2": "toremifene", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of toremifene.", "severity": 2}
{"drug1": "phenindione", "drug2": "cephaloridine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cephaloridine.", "severity": 2}
{"drug1": "warfarin", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefotaxime", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefotaxime.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "warfarin", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "phenindione", "drug2": "cephapirin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cephapirin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "phenindione", "drug2": "LEVOFLOXACIN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "EDTA", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "testosterone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of testosterone.", "severity": 2}
{"drug1": "warfarin", "drug2": "TICARCILLIN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of TICARCILLIN.", "severity": 2}
{"drug1": "warfarin", "drug2": "Pivampicillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Pivampicillin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Pivmecillinam", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Pivmecillinam.", "severity": 2}
{"drug1": "warfarin", "drug2": "bacampicillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of bacampicillin.", "severity": 2}
{"drug1": "warfarin", "drug2": "methicillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of methicillin.", "severity": 2}
{"drug1": "warfarin", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "glipizide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of glipizide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "CYCLACILLIN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of CYCLACILLIN.", "severity": 2}
{"drug1": "phenindione", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "EDTA", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "EDTA", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "EDTA", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "citric acid", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "citric acid", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Gefitinib", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Gefitinib.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "Ditazole", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "warfarin", "drug2": "simvastatin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of simvastatin.", "severity": 2}
{"drug1": "phenindione", "drug2": "Gliquidone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Gliquidone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "argatroban", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "argatroban", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "argatroban", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "Triflusal", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "citric acid", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "argatroban", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "Triflusal", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "citric acid", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "enoxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of enoxacin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "citric acid", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "cilostazol", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "argatroban", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "citric acid", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "argatroban", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "dicumarol", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "phenindione", "drug2": "testosterone propionate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of testosterone propionate.", "severity": 2}
{"drug1": "warfarin", "drug2": "LEVOFLOXACIN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "warfarin", "drug2": "gemcitabine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of gemcitabine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Trovafloxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Trovafloxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "azelastine may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Quinine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Quinine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "cimetidine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cimetidine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "warfarin", "drug2": "Gatifloxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Gatifloxacin.", "severity": 2}
{"drug1": "warfarin", "drug2": "fluocinonide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of fluocinonide.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nortriptyline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of nortriptyline.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "amoxapine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of amoxapine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "chlortetracycline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of chlortetracycline.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Gatifloxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Gatifloxacin.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "warfarin", "drug2": "fludrocortisone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of fludrocortisone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "simvastatin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of simvastatin.", "severity": 2}
{"drug1": "warfarin", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "warfarin", "drug2": "alclometasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of alclometasone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "EDTA", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "warfarin", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "diltiazem", "interaction_type": 6, "interaction_text": "diflunisal may increase the anticoagulant activities of diltiazem.", "severity": 2}
{"drug1": "citric acid", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Tazobactam", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Tazobactam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "TICARCILLIN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of TICARCILLIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Pivampicillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Pivampicillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Pivmecillinam", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Pivmecillinam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "bacampicillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of bacampicillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "methicillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of methicillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "Romidepsin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Romidepsin.", "severity": 2}
{"drug1": "phenindione", "drug2": "allopurinol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of allopurinol.", "severity": 2}
{"drug1": "phenindione", "drug2": "ceftazidime", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ceftazidime.", "severity": 2}
{"drug1": "warfarin", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "warfarin", "drug2": "Tianeptine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Tianeptine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "warfarin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "EDTA", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "Sorafenib", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Sorafenib.", "severity": 2}
{"drug1": "warfarin", "drug2": "DESONIDE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of DESONIDE.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "warfarin", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "amitriptyline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of amitriptyline.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "CEFPODOXIME", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CEFPODOXIME.", "severity": 2}
{"drug1": "argatroban", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "phenindione", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "Cefacetrile", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Cefacetrile.", "severity": 2}
{"drug1": "phenindione", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "phenindione", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "Ciclesonide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Ciclesonide.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "phenindione", "drug2": "gliclazide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of gliclazide.", "severity": 2}
{"drug1": "phenindione", "drug2": "tolbutamide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tolbutamide.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "phenindione", "drug2": "demeclocycline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of demeclocycline.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "atorvastatin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of atorvastatin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "argatroban", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "citric acid", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "warfarin", "drug2": "estrone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "Ditazole", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sertraline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of sertraline.", "severity": 2}
{"drug1": "phenindione", "drug2": "glyburide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of glyburide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "Liotrix", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Liotrix.", "severity": 2}
{"drug1": "dicumarol", "drug2": "chlorpropamide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of chlorpropamide.", "severity": 2}
{"drug1": "Ditazole", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "citric acid", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "cilostazol", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fluoxetine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of fluoxetine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "ROSOXACIN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ROSOXACIN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "argatroban", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "EDTA", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of PENTAERYTHRITOL TETRANITRATE.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fleroxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of fleroxacin.", "severity": 2}
{"drug1": "citric acid", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "anagrelide", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ACENOCOUMAROL", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ACENOCOUMAROL.", "severity": 2}
{"drug1": "Triflusal", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cephaloridine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cephaloridine.", "severity": 2}
{"drug1": "argatroban", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "EDTA", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ACENOCOUMAROL", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ACENOCOUMAROL.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "citalopram", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of citalopram.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "citric acid", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "warfarin", "drug2": "flurandrenolide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of flurandrenolide.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "ticlopidine", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of ticlopidine.", "severity": 2}
{"drug1": "tirofiban", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "citric acid", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "desipramine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of desipramine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "citric acid", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Gemifloxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Gemifloxacin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "ILOPROST may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cimetidine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cimetidine.", "severity": 2}
{"drug1": "EDTA", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "citric acid", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "phenindione", "drug2": "Pivmecillinam", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Pivmecillinam.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "warfarin", "drug2": "Halobetasol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Halobetasol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "mirtazapine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of mirtazapine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "EDTA", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "cilostazol", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "mesalamine", "drug2": "diltiazem", "interaction_type": 6, "interaction_text": "mesalamine may increase the anticoagulant activities of diltiazem.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "NANDROLONE DECANOATE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "EDTA", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "phenindione", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "atorvastatin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of atorvastatin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "EDTA", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "warfarin", "drug2": "phenytoin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of phenytoin.", "severity": 2}
{"drug1": "warfarin", "drug2": "medrysone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of medrysone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Gliquidone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Gliquidone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "warfarin", "drug2": "CORTISONE ACETATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CORTISONE ACETATE.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "argatroban", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "citric acid", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "phenytoin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of phenytoin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "argatroban", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "dicumarol", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Ximelagatran", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Ximelagatran.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefoxitin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefoxitin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefotetan", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefotetan.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cephradine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cephradine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ceftizoxime", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ceftizoxime.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "gemfibrozil", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of gemfibrozil.", "severity": 2}
{"drug1": "citric acid", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ROSOXACIN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ROSOXACIN.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "dicumarol", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "Gliquidone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Gliquidone.", "severity": 2}
{"drug1": "citric acid", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "argatroban", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "phenindione", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "argatroban", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "trimipramine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of trimipramine.", "severity": 2}
{"drug1": "phenindione", "drug2": "amoxicillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of amoxicillin.", "severity": 2}
{"drug1": "phenindione", "drug2": "glipizide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of glipizide.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "Apixaban", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "Apixaban", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Pitavastatin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Pitavastatin.", "severity": 2}
{"drug1": "phenindione", "drug2": "Tramadol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Tramadol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefuroxime", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefuroxime.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "clomipramine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of clomipramine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "phenindione", "drug2": "amiodarone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of amiodarone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "argatroban", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "argatroban", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "phenindione", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "phenindione", "drug2": "IVERMECTIN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of IVERMECTIN.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "phenindione", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "phenindione", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "warfarin", "drug2": "trimipramine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of trimipramine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "azlocillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of azlocillin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "glipizide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of glipizide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefotiam", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefotiam.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "citric acid", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "argatroban", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "VERAPAMIL", "interaction_type": 6, "interaction_text": "BALSALAZIDE may increase the anticoagulant activities of VERAPAMIL.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "OXANDROLONE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of OXANDROLONE.", "severity": 2}
{"drug1": "warfarin", "drug2": "triamcinolone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of triamcinolone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "penicillin g", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of penicillin g.", "severity": 2}
{"drug1": "warfarin", "drug2": "testosterone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of testosterone.", "severity": 2}
{"drug1": "phenindione", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "citric acid", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Vorinostat", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Vorinostat.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefuroxime", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefuroxime.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "alprostadil", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "alprostadil may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "gemfibrozil", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of gemfibrozil.", "severity": 2}
{"drug1": "phenindione", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "phenindione", "drug2": "clomipramine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of clomipramine.", "severity": 2}
{"drug1": "EDTA", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "citric acid", "drug2": "EDTA", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of EDTA.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "citric acid", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Tramadol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Tramadol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Cefacetrile", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Cefacetrile.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "warfarin", "drug2": "Dehydroepiandrosterone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Dehydroepiandrosterone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "MEZLOCILLIN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of MEZLOCILLIN.", "severity": 2}
{"drug1": "citric acid", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "warfarin", "drug2": "cinoxacin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cinoxacin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "warfarin", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Fenofibric acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Fenofibric acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "toremifene", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of toremifene.", "severity": 2}
{"drug1": "citric acid", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "citric acid", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "glimepiride", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of glimepiride.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Penicillin G benzathine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Penicillin G benzathine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "SULBACTAM", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of SULBACTAM.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "penicillin v", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of penicillin v.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ampicillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ampicillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "EDTA", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "toremifene", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of toremifene.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Etofibrate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Etofibrate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "CEFIXIME", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of CEFIXIME.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "warfarin", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "warfarin", "drug2": "glipizide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of glipizide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of 3,4-Dihydroxybenzaldehyde.", "severity": 2}
{"drug1": "warfarin", "drug2": "amoxicillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of amoxicillin.", "severity": 2}
{"drug1": "warfarin", "drug2": "azlocillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of azlocillin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "Apixaban", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "glipizide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of glipizide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "duloxetine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of duloxetine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "amoxicillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of amoxicillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "azlocillin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of azlocillin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "doxepin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of doxepin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefadroxil", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefadroxil.", "severity": 2}
{"drug1": "warfarin", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "clomipramine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of clomipramine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "Ditazole", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "warfarin", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "clofibrate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of clofibrate.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "bezafibrate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of bezafibrate.", "severity": 2}
{"drug1": "phenindione", "drug2": "fleroxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fleroxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefoperazone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefoperazone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Fosphenytoin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Fosphenytoin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefamandole", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefamandole.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefazolin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefazolin.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cinoxacin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cinoxacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "toremifene", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of toremifene.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Etofibrate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Etofibrate.", "severity": 2}
{"drug1": "warfarin", "drug2": "clomipramine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of clomipramine.", "severity": 2}
{"drug1": "warfarin", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "LEVOFLOXACIN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "citric acid", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "OXANDROLONE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of OXANDROLONE.", "severity": 2}
{"drug1": "argatroban", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "argatroban", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "testosterone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of testosterone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ethotoin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ethotoin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Liotrix", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Liotrix.", "severity": 2}
{"drug1": "warfarin", "drug2": "amcinonide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of amcinonide.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "diltiazem", "interaction_type": 6, "interaction_text": "TROLAMINE SALICYLATE may increase the anticoagulant activities of diltiazem.", "severity": 2}
{"drug1": "phenindione", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "EDTA", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "imipramine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of imipramine.", "severity": 2}
{"drug1": "warfarin", "drug2": "Mometasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Mometasone.", "severity": 2}
{"drug1": "phenindione", "drug2": "sertraline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sertraline.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "phenindione", "drug2": "L-thyroxine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of L-thyroxine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "phenindione", "drug2": "cephalothin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cephalothin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "phenindione", "drug2": "chlorpropamide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of chlorpropamide.", "severity": 2}
{"drug1": "phenindione", "drug2": "CEFIXIME", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of CEFIXIME.", "severity": 2}
{"drug1": "dicumarol", "drug2": "norfloxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of norfloxacin.", "severity": 2}
{"drug1": "phenindione", "drug2": "tamoxifen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tamoxifen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "penicillin g", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of penicillin g.", "severity": 2}
{"drug1": "warfarin", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "warfarin", "drug2": "ethotoin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ethotoin.", "severity": 2}
{"drug1": "warfarin", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ADAPALENE", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ADAPALENE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "atorvastatin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of atorvastatin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "citric acid", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Etofibrate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Etofibrate.", "severity": 2}
{"drug1": "citric acid", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "Apixaban", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "warfarin", "drug2": "prednisone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of prednisone.", "severity": 2}
{"drug1": "warfarin", "drug2": "clofibrate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of clofibrate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "gliclazide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of gliclazide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "warfarin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "phenindione", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "phenindione", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "imipramine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of imipramine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cephalothin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cephalothin.", "severity": 2}
{"drug1": "warfarin", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "L-thyroxine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of L-thyroxine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "warfarin", "drug2": "cefaclor", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cefaclor.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "argatroban", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "warfarin", "drug2": "CLOCORTOLONE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of CLOCORTOLONE.", "severity": 2}
{"drug1": "warfarin", "drug2": "tolazamide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tolazamide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "citric acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of citric acid.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "argatroban", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "citric acid", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "phenindione", "drug2": "ceftriaxone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ceftriaxone.", "severity": 2}
{"drug1": "Triflusal", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "amoxapine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of amoxapine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "TROLAMINE SALICYLATE may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "Triflusal", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "citric acid", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "Apixaban", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "argatroban", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "argatroban", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "EDTA", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "EDTA", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "phenindione", "drug2": "bacampicillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of bacampicillin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "piperacillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of piperacillin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "citric acid", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "acetaminophen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of acetaminophen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Gefitinib", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Gefitinib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Gatifloxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Gatifloxacin.", "severity": 2}
{"drug1": "EDTA", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "warfarin", "drug2": "minocycline", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of minocycline.", "severity": 2}
{"drug1": "warfarin", "drug2": "glyburide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of glyburide.", "severity": 2}
{"drug1": "warfarin", "drug2": "sulfamethoxazole", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of sulfamethoxazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "phenindione", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "Apixaban", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "toremifene", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of toremifene.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cephaloridine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cephaloridine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "sevoflurane may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "citric acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of citric acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "testosterone propionate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of testosterone propionate.", "severity": 2}
{"drug1": "phenindione", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "minocycline", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of minocycline.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "glyburide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of glyburide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sulfamethoxazole", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of sulfamethoxazole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "danazol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of danazol.", "severity": 2}
{"drug1": "warfarin", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cephapirin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cephapirin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "EDTA", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "EDTA", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Pitavastatin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Pitavastatin.", "severity": 2}
{"drug1": "argatroban", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "warfarin", "drug2": "gliclazide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of gliclazide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "testosterone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of testosterone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "OXANDROLONE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of OXANDROLONE.", "severity": 2}
{"drug1": "aspirin", "drug2": "VERAPAMIL", "interaction_type": 6, "interaction_text": "aspirin may increase the anticoagulant activities of VERAPAMIL.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Ditazole", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "gliclazide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of gliclazide.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefaclor", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefaclor.", "severity": 2}
{"drug1": "argatroban", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "warfarin", "drug2": "oxacillin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of oxacillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tolazamide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tolazamide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "warfarin", "drug2": "ceftriaxone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ceftriaxone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "glyburide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of glyburide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Tianeptine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Tianeptine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "warfarin", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "warfarin", "drug2": "dexamethasone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of dexamethasone.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "phenindione", "drug2": "CEFONICID", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of CEFONICID.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "clofibrate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of clofibrate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "bacampicillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of bacampicillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "methicillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of methicillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Pivampicillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Pivampicillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Pivmecillinam", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Pivmecillinam.", "severity": 2}
{"drug1": "dicumarol", "drug2": "TICARCILLIN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of TICARCILLIN.", "severity": 2}
{"drug1": "phenindione", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "anagrelide", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "anagrelide", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "warfarin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "citric acid", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "trapidil", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "trapidil may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Teriflunomide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Teriflunomide.", "severity": 2}
{"drug1": "EDTA", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "EDTA", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "phenindione", "drug2": "chloramphenicol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of chloramphenicol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "argatroban", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "argatroban", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Gatifloxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Gatifloxacin.", "severity": 2}
{"drug1": "warfarin", "drug2": "hydrocortisone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of hydrocortisone.", "severity": 2}
{"drug1": "phenindione", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "phenindione", "drug2": "bezafibrate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of bezafibrate.", "severity": 2}
{"drug1": "warfarin", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "TROLAMINE SALICYLATE may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "Ditazole", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Ditazole", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "warfarin", "drug2": "IVERMECTIN", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of IVERMECTIN.", "severity": 2}
{"drug1": "phenindione", "drug2": "paroxetine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of paroxetine.", "severity": 2}
{"drug1": "phenindione", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "warfarin", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "phenindione", "drug2": "oxacillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of oxacillin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "pentosan polysulfate", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of pentosan polysulfate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "warfarin", "drug2": "equilin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of equilin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "warfarin", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of warfarin.", "severity": 2}
{"drug1": "tirofiban", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "phenindione", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "phenindione", "drug2": "Fenofibric acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Fenofibric acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "stanozolol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of stanozolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "Ditazole", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "EDTA", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of EDTA.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "citric acid", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "citric acid", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "EDTA", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "citric acid", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "EDTA", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "EDTA", "drug2": "tolfenamic acid", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of tolfenamic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "fluvastatin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fluvastatin.", "severity": 2}
{"drug1": "EDTA", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "EDTA", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "pentoxifylline may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "phenindione", "drug2": "Tianeptine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Tianeptine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "citric acid", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Apixaban", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "Triflusal", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Cangrelor may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "warfarin", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "phenindione", "drug2": "Loxoprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Loxoprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Tazobactam", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Tazobactam.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "allopurinol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of allopurinol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ceftazidime", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ceftazidime.", "severity": 2}
{"drug1": "warfarin", "drug2": "DEFLAZACORT", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of DEFLAZACORT.", "severity": 2}
{"drug1": "citric acid", "drug2": "Salsalate", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Salsalate.", "severity": 2}
{"drug1": "EDTA", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "citric acid", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "amitriptyline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of amitriptyline.", "severity": 2}
{"drug1": "citric acid", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "argatroban", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "warfarin", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "argatroban", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "penicillin g", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of penicillin g.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cimetidine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cimetidine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "NANDROLONE DECANOATE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ketoprofen", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ketoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "CYCLACILLIN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of CYCLACILLIN.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "gliclazide", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of gliclazide.", "severity": 2}
{"drug1": "citric acid", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Sugammadex", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Sugammadex.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "citric acid", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "warfarin", "drug2": "atorvastatin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of atorvastatin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "demeclocycline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of demeclocycline.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "warfarin", "drug2": "PREDNICARBATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of PREDNICARBATE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "warfarin", "drug2": "cephapirin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cephapirin.", "severity": 2}
{"drug1": "phenindione", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefotaxime", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefotaxime.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "LEVOFLOXACIN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "mesalamine", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of mesalamine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefmetazole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefmetazole.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "warfarin", "drug2": "Tramadol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Tramadol.", "severity": 2}
{"drug1": "phenindione", "drug2": "liothyronine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of liothyronine.", "severity": 2}
{"drug1": "phenindione", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "EDTA", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "warfarin", "drug2": "budesonide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of budesonide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Tramadol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Tramadol.", "severity": 2}
{"drug1": "citric acid", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tamoxifen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tamoxifen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "IVERMECTIN", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of IVERMECTIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "pravastatin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of pravastatin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "EDTA", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "warfarin", "drug2": "epirizole", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of epirizole.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "SERATRODAST", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of SERATRODAST.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "argatroban", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of argatroban.", "severity": 2}
{"drug1": "phenindione", "drug2": "duloxetine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of duloxetine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "phenindione", "drug2": "fluoxetine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of fluoxetine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cephaloridine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cephaloridine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fenofibrate", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of fenofibrate.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "warfarin", "drug2": "floctafenine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of floctafenine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "warfarin", "drug2": "FLUOCORTOLONE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of FLUOCORTOLONE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Fluprednidene", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Fluprednidene.", "severity": 2}
{"drug1": "warfarin", "drug2": "nalidixic acid", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of nalidixic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "Prasugrel", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Prasugrel.", "severity": 2}
{"drug1": "warfarin", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "dicumarol", "drug2": "desipramine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of desipramine.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefotaxime", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefotaxime.", "severity": 2}
{"drug1": "warfarin", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Fondaparinux", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Fondaparinux.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "warfarin", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "suprofen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of suprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "pravastatin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of pravastatin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nalidixic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of nalidixic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "phenindione", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "etoposide", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of etoposide.", "severity": 2}
{"drug1": "phenindione", "drug2": "minocycline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of minocycline.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sparfloxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of sparfloxacin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "phenindione", "drug2": "nortriptyline", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of nortriptyline.", "severity": 2}
{"drug1": "warfarin", "drug2": "demeclocycline", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of demeclocycline.", "severity": 2}
{"drug1": "warfarin", "drug2": "Imatinib", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Imatinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "trimipramine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of trimipramine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "doxepin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of doxepin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefadroxil", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefadroxil.", "severity": 2}
{"drug1": "argatroban", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "nefazodone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of nefazodone.", "severity": 2}
{"drug1": "citric acid", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "warfarin", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "warfarin", "drug2": "Liotrix", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Liotrix.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "milrinone", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of milrinone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "argatroban", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ceftazidime", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ceftazidime.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "allopurinol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of allopurinol.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cefazolin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of cefazolin.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "PHENPROCOUMON", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of PHENPROCOUMON.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ACENOCOUMAROL", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of ACENOCOUMAROL.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "warfarin", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "warfarin", "drug2": "cimetidine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of cimetidine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "salicylamide", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of salicylamide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ibuprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ibuprofen.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "mefenamic acid", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of mefenamic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "Ceftobiprole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Ceftobiprole.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "argatroban", "drug2": "ZILEUTON", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ZILEUTON.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "tibolone", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of tibolone.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "argatroban", "drug2": "etodolac", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of etodolac.", "severity": 2}
{"drug1": "anagrelide", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "phenindione", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "argatroban", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "citric acid", "drug2": "leflunomide", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of leflunomide.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "dicumarol", "drug2": "trimipramine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of trimipramine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "diclofenac", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of diclofenac.", "severity": 2}
{"drug1": "argatroban", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "citric acid", "drug2": "ACENOCOUMAROL", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of ACENOCOUMAROL.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "rosiglitazone may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "phenindione", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "antipyrine", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of antipyrine.", "severity": 2}
{"drug1": "argatroban", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "EDTA", "drug2": "Apremilast", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Apremilast.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Fenofibric acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of Fenofibric acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "nortriptyline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of nortriptyline.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "EDTA", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "phenindione", "drug2": "tolazamide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tolazamide.", "severity": 2}
{"drug1": "phenindione", "drug2": "CYCLACILLIN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of CYCLACILLIN.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ACENOCOUMAROL", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ACENOCOUMAROL.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "TROLAMINE SALICYLATE may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "citric acid", "drug2": "Olsalazine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Olsalazine.", "severity": 2}
{"drug1": "citric acid", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "EDTA", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "azlocillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of azlocillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "amoxicillin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of amoxicillin.", "severity": 2}
{"drug1": "warfarin", "drug2": "tolterodine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of tolterodine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "indomethacin", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of indomethacin.", "severity": 2}
{"drug1": "anagrelide", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "argatroban", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "warfarin", "drug2": "fenofibrate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of fenofibrate.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "PIRFENIDONE", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of PIRFENIDONE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "citric acid", "drug2": "trapidil", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of trapidil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Pitavastatin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Pitavastatin.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "niflumic acid", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of niflumic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fenofibrate", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of fenofibrate.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Tramadol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Tramadol.", "severity": 2}
{"drug1": "citric acid", "drug2": "Propacetamol", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Propacetamol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "tirofiban", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Vorapaxar may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "amiodarone", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of amiodarone.", "severity": 2}
{"drug1": "EDTA", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "EDTA", "drug2": "Treprostinil", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Treprostinil.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "sulfinpyrazone", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of sulfinpyrazone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "dicumarol", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of dicumarol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Vorinostat", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Vorinostat.", "severity": 2}
{"drug1": "argatroban", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sulindac", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of sulindac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "IVERMECTIN", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of IVERMECTIN.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "phenindione", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "argatroban", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "EDTA", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "methyltestosterone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of methyltestosterone.", "severity": 2}
{"drug1": "EDTA", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "EDTA", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "warfarin", "drug2": "flunisolide", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of flunisolide.", "severity": 2}
{"drug1": "phenindione", "drug2": "cefmenoxime", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of cefmenoxime.", "severity": 2}
{"drug1": "phenindione", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "phenindione", "drug2": "sulfisoxazole", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of sulfisoxazole.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "warfarin", "drug2": "protriptyline", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of protriptyline.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "dicumarol", "drug2": "methyltestosterone", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of methyltestosterone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "resveratrol may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "stanozolol", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of stanozolol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "penicillin v", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of penicillin v.", "severity": 2}
{"drug1": "EDTA", "drug2": "Cangrelor", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of Cangrelor.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "protriptyline", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of protriptyline.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "clopidogrel may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "demeclocycline", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of demeclocycline.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "gemfibrozil", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of gemfibrozil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "epoprostenol", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of epoprostenol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ceftriaxone", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of ceftriaxone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "Apixaban", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Apixaban.", "severity": 2}
{"drug1": "phenindione", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "LEVOFLOXACIN", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "zaltoprofen", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of zaltoprofen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "anagrelide", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "cilostazol may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "anagrelide", "drug2": "epinastine", "interaction_type": 6, "interaction_text": "anagrelide may increase the anticoagulant activities of epinastine.", "severity": 2}
{"drug1": "warfarin", "drug2": "Etofibrate", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Etofibrate.", "severity": 2}
{"drug1": "warfarin", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "warfarin", "drug2": "ETOFENAMATE", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "chloroquine", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of chloroquine.", "severity": 2}
{"drug1": "phenindione", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "phenindione", "drug2": "enoxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of enoxacin.", "severity": 2}
{"drug1": "phenindione", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "oxyphenbutazone", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of oxyphenbutazone.", "severity": 2}
{"drug1": "phenindione", "drug2": "Quinine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Quinine.", "severity": 2}
{"drug1": "phenindione", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tolmetin", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of tolmetin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cimetidine", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cimetidine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "warfarin", "drug2": "methyltestosterone", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of methyltestosterone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "tirofiban", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of tirofiban.", "severity": 2}
{"drug1": "phenindione", "drug2": "simvastatin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of simvastatin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Escitalopram", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Escitalopram.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Aceclofenac", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Aceclofenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "Olopatadine", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of Olopatadine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "Ticagrelor may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Pefloxacin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Pefloxacin.", "severity": 2}
{"drug1": "phenindione", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "EDTA", "drug2": "cilostazol", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of cilostazol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "Apixaban", "drug2": "diflunisal", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of diflunisal.", "severity": 2}
{"drug1": "warfarin", "drug2": "VITAMIN E", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of VITAMIN E.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "Dabigatran etexilate may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Nepafenac", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Nepafenac.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "BALSALAZIDE", "interaction_type": 6, "interaction_text": "TROLAMINE SALICYLATE may increase the anticoagulant activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "rosiglitazone", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of rosiglitazone.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Ditazole", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "phenindione", "drug2": "Pivampicillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Pivampicillin.", "severity": 2}
{"drug1": "phenindione", "drug2": "TICARCILLIN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of TICARCILLIN.", "severity": 2}
{"drug1": "phenindione", "drug2": "Tazobactam", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Tazobactam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Ditazole", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of Ditazole.", "severity": 2}
{"drug1": "phenindione", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "phenindione", "drug2": "methicillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of methicillin.", "severity": 2}
{"drug1": "argatroban", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "fenbufen", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of fenbufen.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "phenindione", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "tirofiban", "drug2": "alprostadil", "interaction_type": 6, "interaction_text": "tirofiban may increase the anticoagulant activities of alprostadil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "NAPROXEN", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of NAPROXEN.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tolazamide", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of tolazamide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Gemifloxacin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of Gemifloxacin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ethotoin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of ethotoin.", "severity": 2}
{"drug1": "argatroban", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "argatroban", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "dicumarol", "drug2": "nalidixic acid", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of nalidixic acid.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "dicumarol", "drug2": "alclofenac", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of alclofenac.", "severity": 2}
{"drug1": "citric acid", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Pimecrolimus", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Pimecrolimus.", "severity": 2}
{"drug1": "argatroban", "drug2": "Droxicam", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Droxicam.", "severity": 2}
{"drug1": "argatroban", "drug2": "CLONIXIN", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of CLONIXIN.", "severity": 2}
{"drug1": "citric acid", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "warfarin may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Icatibant", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of Icatibant.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "ethyl icosapentate", "interaction_type": 6, "interaction_text": "dipyridamole may increase the anticoagulant activities of ethyl icosapentate.", "severity": 2}
{"drug1": "phenindione", "drug2": "methyltestosterone", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of methyltestosterone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "sulfasalazine", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of sulfasalazine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "salicylic acid", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of salicylic acid.", "severity": 2}
{"drug1": "dicumarol", "drug2": "chlortetracycline", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of chlortetracycline.", "severity": 2}
{"drug1": "argatroban", "drug2": "clopidogrel", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of clopidogrel.", "severity": 2}
{"drug1": "citric acid", "drug2": "Naftifine", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Naftifine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "meclofenamic acid", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of meclofenamic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "argatroban", "drug2": "Masoprocol", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Masoprocol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ILOPROST", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of ILOPROST.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "oxaprozin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of oxaprozin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "oxacillin", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of oxacillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "paroxetine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of paroxetine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "BENZYDAMINE", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ibudilast", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of ibudilast.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Ifenprodil", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of Ifenprodil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cefuroxime", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cefuroxime.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fleroxacin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of fleroxacin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "argatroban", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cefotiam", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of cefotiam.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "mycophenolate mofetil", "interaction_type": 6, "interaction_text": "pentosan polysulfate may increase the anticoagulant activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "phenindione", "drug2": "azlocillin", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of azlocillin.", "severity": 2}
{"drug1": "citric acid", "drug2": "tiaprofenic acid", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of tiaprofenic acid.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Choline magnesium trisalicylate", "interaction_type": 6, "interaction_text": "Ximelagatran may increase the anticoagulant activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "argatroban", "drug2": "Magnesium salicylate", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Magnesium salicylate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "dipyridamole", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of dipyridamole.", "severity": 2}
{"drug1": "ibudilast", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "ibudilast may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fenoprofen", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of fenoprofen.", "severity": 2}
{"drug1": "Ditazole", "drug2": "Vorapaxar", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of Vorapaxar.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Ifenprodil may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "Triflusal", "drug2": "anagrelide", "interaction_type": 6, "interaction_text": "Triflusal may increase the anticoagulant activities of anagrelide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "mirtazapine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of mirtazapine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "celecoxib", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of celecoxib.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "Fondaparinux may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "phenindione", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "resveratrol", "interaction_type": 6, "interaction_text": "Bivalirudin may increase the anticoagulant activities of resveratrol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "aspirin", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of aspirin.", "severity": 2}
{"drug1": "phenindione", "drug2": "EDOXABAN", "interaction_type": 6, "interaction_text": "phenindione may increase the anticoagulant activities of EDOXABAN.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "pentoxifylline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of pentoxifylline.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Dasatinib", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of Dasatinib.", "severity": 2}
{"drug1": "EDTA", "drug2": "sevoflurane", "interaction_type": 6, "interaction_text": "EDTA may increase the anticoagulant activities of sevoflurane.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tenoxicam", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of tenoxicam.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "phenindione", "interaction_type": 6, "interaction_text": "Rivaroxaban may increase the anticoagulant activities of phenindione.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "flurbiprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of flurbiprofen.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "nimesulide", "interaction_type": 6, "interaction_text": "Prasugrel may increase the anticoagulant activities of nimesulide.", "severity": 2}
{"drug1": "citric acid", "drug2": "Lornoxicam", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Lornoxicam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "nabumetone", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of nabumetone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ketorolac", "interaction_type": 6, "interaction_text": "Apixaban may increase the anticoagulant activities of ketorolac.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Dabigatran etexilate", "interaction_type": 6, "interaction_text": "EDOXABAN may increase the anticoagulant activities of Dabigatran etexilate.", "severity": 2}
{"drug1": "citric acid", "drug2": "Lumiracoxib", "interaction_type": 6, "interaction_text": "citric acid may increase the anticoagulant activities of Lumiracoxib.", "severity": 2}
{"drug1": "Ditazole", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "mycophenolic acid", "interaction_type": 6, "interaction_text": "ACENOCOUMAROL may increase the anticoagulant activities of mycophenolic acid.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Triflusal", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of Triflusal.", "severity": 2}
{"drug1": "dicumarol", "drug2": "azelastine", "interaction_type": 6, "interaction_text": "dicumarol may increase the anticoagulant activities of azelastine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "carprofen", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of carprofen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "imipramine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of imipramine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sertraline", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of sertraline.", "severity": 2}
{"drug1": "argatroban", "drug2": "Etoricoxib", "interaction_type": 6, "interaction_text": "argatroban may increase the anticoagulant activities of Etoricoxib.", "severity": 2}
{"drug1": "Ditazole", "drug2": "Ticagrelor", "interaction_type": 6, "interaction_text": "Ditazole may increase the anticoagulant activities of Ticagrelor.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "L-thyroxine", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of L-thyroxine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Bivalirudin", "interaction_type": 6, "interaction_text": "3,4-Dihydroxybenzaldehyde may increase the anticoagulant activities of Bivalirudin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cephalothin", "interaction_type": 6, "interaction_text": "PHENPROCOUMON may increase the anticoagulant activities of cephalothin.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Amrubicin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of Amrubicin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "ribostamycin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of ribostamycin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "Epirubicin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of Epirubicin.", "severity": 3}
{"drug1": "ETHACRYNIC ACID", "drug2": "furosemide", "interaction_type": 7, "interaction_text": "ETHACRYNIC ACID may increase the ototoxic activities of furosemide.", "severity": 3}
{"drug1": "carboplatin", "drug2": "doxorubicin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of doxorubicin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "Valrubicin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of Valrubicin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "kanamycin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of kanamycin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "streptomycin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of streptomycin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "amikacin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of amikacin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "IDARUBICIN", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of IDARUBICIN.", "severity": 3}
{"drug1": "carboplatin", "drug2": "plicamycin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of plicamycin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "gentamicin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of gentamicin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "streptozocin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of streptozocin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "Arbekacin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of Arbekacin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "metrizamide", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of metrizamide.", "severity": 3}
{"drug1": "carboplatin", "drug2": "daunorubicin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of daunorubicin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "paromomycin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of paromomycin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "netilmicin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of netilmicin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "tobramycin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of tobramycin.", "severity": 3}
{"drug1": "carboplatin", "drug2": "Spectinomycin", "interaction_type": 7, "interaction_text": "carboplatin may increase the ototoxic activities of Spectinomycin.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "pimozide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of pimozide can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "imipramine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of imipramine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "selegiline", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with selegiline.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "prazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of prazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "quazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of quazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "KETAZOLAM", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of KETAZOLAM can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Lormetazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Lormetazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "glyburide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of glyburide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "oxprenolol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of oxprenolol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Miglustat", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Miglustat can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Oxetacaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Oxetacaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "chlorzoxazone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of chlorzoxazone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "DESFLURANE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of DESFLURANE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Melatonin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Melatonin can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "glimepiride", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of glimepiride can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "bupivacaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of bupivacaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Ethylmorphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Ethylmorphine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Fencamfamin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Fencamfamin can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Etomidate", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Etomidate can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "prilocaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of prilocaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "tranylcypromine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of tranylcypromine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "isoflurane", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of isoflurane can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "chlorpropamide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of chlorpropamide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Difenoxin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Difenoxin can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Alogliptin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Alogliptin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Desloratadine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Desloratadine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Remoxipride", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Remoxipride can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "nalbuphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of nalbuphine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Pipamperone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Pipamperone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "lidocaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of lidocaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "promethazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of promethazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Articaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Articaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Tramadol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Tramadol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "pentazocine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of pentazocine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "reserpine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of reserpine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "cocaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of cocaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "doxepin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of doxepin can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "diphenhydramine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of diphenhydramine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "midazolam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of midazolam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clomipramine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of clomipramine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "proparacaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of proparacaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "TRICHLOROETHYLENE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of TRICHLOROETHYLENE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tolbutamide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of tolbutamide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Olopatadine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Olopatadine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "fluvoxamine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of fluvoxamine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "gliclazide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of gliclazide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clemastine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of clemastine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "meperidine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of meperidine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clozapine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of clozapine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "chlormezanone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of chlormezanone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Saxagliptin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Saxagliptin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "thiopental", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of thiopental can be increased when used in combination with sulfisoxazole.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Flibanserin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Flibanserin can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "brotizolam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of brotizolam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nateglinide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of nateglinide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "azelastine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of azelastine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Flupentixol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Flupentixol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Pomalidomide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Pomalidomide can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Aripiprazole", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Aripiprazole can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with isocarboxazid.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "chlordiazepoxide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of chlordiazepoxide can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "GUANFACINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of GUANFACINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tolazamide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of tolazamide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "triazolam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of triazolam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Levobupivacaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Levobupivacaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "REMIFENTANIL", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of REMIFENTANIL can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Asenapine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Asenapine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "zotepine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of zotepine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "tiapride", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of tiapride can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "CHLOROPROCAINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of CHLOROPROCAINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Pioglitazone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Pioglitazone can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "succinylcholine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of succinylcholine can be increased when used in combination with Bambuterol.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "trifluoperazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of trifluoperazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with Pirlindole.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clidinium", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of clidinium can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "sevoflurane", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of sevoflurane can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Ropivacaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Ropivacaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "DIPHENOXYLATE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of DIPHENOXYLATE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "chloral hydrate", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of chloral hydrate can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Agomelatine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Agomelatine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "benzocaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of benzocaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "rosiglitazone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of rosiglitazone can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clonidine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of clonidine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "thioridazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of thioridazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "butamben", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of butamben can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "acarbose", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of acarbose can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ethyl loflazepate", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of ethyl loflazepate can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "triprolidine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of triprolidine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "nitrous oxide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of nitrous oxide can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "MIGLITOL", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of MIGLITOL can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with AMPHETAMINE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "tetracaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of tetracaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "DIHYDROCODEINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of DIHYDROCODEINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Empagliflozin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Empagliflozin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Pipotiazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Pipotiazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of FLUTICASONE PROPIONATE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "desipramine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of desipramine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Ketobemidone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Ketobemidone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "thiamylal", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of thiamylal can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Fluspirilene", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Fluspirilene can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "quetiapine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of quetiapine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "TETRABENAZINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of TETRABENAZINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ketamine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of ketamine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "BREXPIPRAZOLE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of BREXPIPRAZOLE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "METAXALONE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of METAXALONE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with moclobemide.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "fexofenadine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of fexofenadine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "propofol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of propofol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "flurazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of flurazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Etidocaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Etidocaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "SUFENTANIL", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of SUFENTANIL can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "nortriptyline", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of nortriptyline can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "amoxapine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of amoxapine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with rasagiline.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Gliquidone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Gliquidone can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "mepivacaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of mepivacaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Gabapentin enacarbil", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Gabapentin enacarbil can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "etizolam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of etizolam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "triflupromazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of triflupromazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "codeine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of codeine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with tranylcypromine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "METHOHEXITAL", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of METHOHEXITAL can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "pentobarbital", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of pentobarbital can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with Phenelzine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "methoxyflurane", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of methoxyflurane can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "DEZOCINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of DEZOCINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "halothane", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of halothane can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Vildagliptin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Vildagliptin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "chlorprothixene", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of chlorprothixene can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with furazolidone.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "levodopa", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of levodopa can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "voglibose", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of voglibose can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "trazodone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of trazodone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "flunitrazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of flunitrazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "secobarbital", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of secobarbital can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "thiothixene", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of thiothixene can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "sulpiride", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of sulpiride can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "pargyline", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with pargyline.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with Toloxatone.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "carisoprodol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of carisoprodol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Zuclopenthixol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Zuclopenthixol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "oxycodone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of oxycodone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Halazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Halazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ALFENTANIL", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of ALFENTANIL can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with procarbazine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "buspirone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of buspirone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "cyclobenzaprine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of cyclobenzaprine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "methylene blue", "drug2": "morphine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of morphine can be increased when used in combination with methylene blue.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Aceprometazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Aceprometazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of 4-Hydroxybutanoic acid can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "hydromorphone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of hydromorphone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "amitriptyline", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of amitriptyline can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "oxazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of oxazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Tolcapone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Tolcapone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Ziprasidone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Ziprasidone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Ramelteon", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Ramelteon can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "DIMENHYDRINATE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of DIMENHYDRINATE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "butalbital", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of butalbital can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Fospropofol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Fospropofol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Dexbrompheniramine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Dexbrompheniramine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Eszopiclone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Eszopiclone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "amisulpride", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of amisulpride can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "loxapine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of loxapine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "propoxyphene", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of propoxyphene can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "dyclonine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of dyclonine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "glutethimide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of glutethimide can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Iloperidone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Iloperidone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "dibucaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of dibucaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Methadyl acetate", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Methadyl acetate can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "SERTINDOLE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of SERTINDOLE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "procaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of procaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Repaglinide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Repaglinide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "trimipramine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of trimipramine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "maprotiline", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of maprotiline can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "MELPERONE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of MELPERONE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "CYCLIZINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of CYCLIZINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "mesoridazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of mesoridazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Canagliflozin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Canagliflozin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "CYPROHEPTADINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of CYPROHEPTADINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "baclofen", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of baclofen can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "methadone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of methadone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "thalidomide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of thalidomide can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "olanzapine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of olanzapine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ethchlorvynol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of ethchlorvynol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "temazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of temazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "butabarbital", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of butabarbital can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "loratadine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of loratadine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Pramocaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Pramocaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "prochlorperazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of prochlorperazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Levocetirizine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Levocetirizine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Propoxycaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Propoxycaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "lithium ion", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of lithium ion can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "metformin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of metformin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Hexobarbital", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Hexobarbital can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Butethal", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Butethal can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "amobarbital", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of amobarbital can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "dantrolene", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of dantrolene can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "alprazolam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of alprazolam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "meclizine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of meclizine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "risperidone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of risperidone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Pizotifen", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Pizotifen can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "butorphanol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of butorphanol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of DEXMEDETOMIDINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Oxybuprocaine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Oxybuprocaine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ondansetron", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of ondansetron can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Lurasidone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Lurasidone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Perospirone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Perospirone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "enflurane", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of enflurane can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "chlorpheniramine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of chlorpheniramine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "VORTIOXETINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of VORTIOXETINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "glipizide", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of glipizide can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "methocarbamol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of methocarbamol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "promazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of promazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "benzyl alcohol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of benzyl alcohol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "MOLINDONE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of MOLINDONE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "protriptyline", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of protriptyline can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Paliperidone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Paliperidone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "zopiclone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of zopiclone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "cetirizine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of cetirizine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Normethadone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Normethadone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "haloperidol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of haloperidol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "HEROIN", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of HEROIN can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "scopolamine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of scopolamine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Tasimelteon", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Tasimelteon can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Linagliptin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Linagliptin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Sitagliptin", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of Sitagliptin can be increased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "FLUPHENAZINE", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of FLUPHENAZINE can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "bromazepam", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of bromazepam can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "levorphanol", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of levorphanol can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "oxymorphone", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of oxymorphone can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "perphenazine", "interaction_type": 8, "interaction_text": "The therapeutic efficacy of perphenazine can be increased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "practolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "glipizide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "acarbose", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Linagliptin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "pentamidine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of pentamidine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "glipizide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "glipizide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "mifepristone", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "mifepristone", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "sulfadiazine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of sulfadiazine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Quinine", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "metformin", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "nateglinide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Quinine", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "mifepristone", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Quinine", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "glipizide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "glyburide", "drug2": "practolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "glyburide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "glipizide", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "glyburide", "drug2": "carvedilol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of carvedilol.", "severity": 2}
{"drug1": "glyburide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "glipizide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "glyburide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "disopyramide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "glimepiride", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "atorvastatin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of atorvastatin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "gliclazide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "tolazamide", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "sulfisoxazole", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of sulfisoxazole.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "gemfibrozil", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of gemfibrozil.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "glyburide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glipizide", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "glipizide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "glyburide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "sulfisoxazole", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of sulfisoxazole.", "severity": 2}
{"drug1": "tolazamide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "metformin", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "metformin", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "practolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "glipizide", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "tolazamide", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "pentamidine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "glipizide", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "acarbose", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "glyburide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "glyburide", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "glyburide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "glimepiride", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "tolbutamide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of tolbutamide.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "gliclazide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of gliclazide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "glimepiride", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "mifepristone", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "glyburide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "glyburide", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "glipizide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Quinine", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "acarbose", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "acarbose", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "metformin", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "metformin", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "gliclazide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "acarbose", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "glyburide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "nateglinide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "glimepiride", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "glimepiride", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "nateglinide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "glimepiride", "drug2": "carvedilol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of carvedilol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "disopyramide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "pentamidine", "drug2": "sulfadiazine", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of sulfadiazine.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "glipizide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of glipizide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "glyburide", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "glyburide", "drug2": "timolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "glipizide", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "glyburide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "glyburide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "glipizide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "glipizide", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "acarbose", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "disopyramide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "timolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "glyburide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "glyburide", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "gliclazide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "glyburide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "glyburide", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "glipizide", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Quinine", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "acarbose", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "glyburide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "metformin", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "Quinine", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "glipizide", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "acarbose", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "acarbose", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "metformin", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "glipizide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "acarbose", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "acarbose", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "metformin", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Quinine", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "glipizide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "glipizide", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "metformin", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "Quinine", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "glipizide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Pasireotide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of Pasireotide.", "severity": 2}
{"drug1": "glipizide", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "glipizide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "glipizide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "glipizide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "pentamidine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of pentamidine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "glyburide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "glyburide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "disopyramide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "glyburide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "glyburide", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "glipizide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "glyburide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "acarbose", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "Quinine", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "glimepiride", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "atorvastatin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of atorvastatin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "mifepristone", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "practolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "glipizide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "glipizide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "glipizide", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "metformin", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "glyburide", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "metformin", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "atorvastatin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of atorvastatin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "disopyramide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "metformin", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "metformin", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "glipizide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "Quinine", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "glyburide", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "glyburide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glyburide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "glyburide", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "glyburide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "disopyramide", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "glipizide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "metformin", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "metformin", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "gliclazide", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "metformin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "tolazamide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "glyburide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "glyburide", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "glipizide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "sulfadiazine", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of sulfadiazine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Quinine", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "acarbose", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "glimepiride", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "glimepiride", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "acarbose", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "acarbose", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "Quinine", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "acarbose", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Quinine", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "glipizide", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "metformin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "glipizide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "gliclazide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of gliclazide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "tolbutamide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of tolbutamide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "tolazamide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Quinine", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "metformin", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Miglustat", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Miglustat may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "metformin", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "acarbose", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "metformin", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "tolazamide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "acarbose", "drug2": "fluvoxamine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of fluvoxamine.", "severity": 2}
{"drug1": "glyburide", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "glipizide", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "glyburide", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "gliclazide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "metformin", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "carvedilol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of carvedilol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "tolazamide", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "Quinine", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "glyburide", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "glimepiride", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "tolazamide", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "tolazamide", "drug2": "mifepristone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of mifepristone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "mifepristone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "practolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "pentamidine", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of pentamidine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "glipizide", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "glyburide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "gliclazide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "metformin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "metformin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "glyburide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of glyburide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "acarbose", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "acarbose", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "acarbose", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "glipizide", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "metformin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "nateglinide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "glipizide", "drug2": "sulfamethoxazole", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of sulfamethoxazole.", "severity": 2}
{"drug1": "glipizide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "glipizide", "drug2": "glyburide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of glyburide.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "mifepristone", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "glimepiride", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "metformin", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "metformin", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "pentamidine", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "glipizide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of glipizide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "metformin", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "acarbose", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "pentamidine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of pentamidine.", "severity": 2}
{"drug1": "glyburide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Quinine", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "glipizide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "metformin", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "metformin", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "metformin", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "glyburide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "Quinine", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "glimepiride", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "metformin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "glyburide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "gliclazide", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "glyburide", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "timolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "glyburide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Quinine", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "acarbose", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "glyburide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "glyburide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "acarbose", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "acarbose", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "acarbose", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "acarbose", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "timolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "carvedilol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of carvedilol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "gliclazide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "nateglinide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "sulfadiazine", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of sulfadiazine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "sulfadiazine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of sulfadiazine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "metformin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "pentamidine", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "timolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glipizide", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Quinine", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "nateglinide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "glipizide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "tolazamide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "fluvoxamine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of fluvoxamine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glipizide", "drug2": "pentamidine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of pentamidine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "glipizide", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "glipizide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "glyburide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "acarbose", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "glyburide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "glyburide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "glyburide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Quinine", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "glipizide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "glipizide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "glipizide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "glimepiride", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Posaconazole", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Posaconazole.", "severity": 2}
{"drug1": "glyburide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "gliclazide", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glyburide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "tolazamide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "sulfamethoxazole", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of sulfamethoxazole.", "severity": 2}
{"drug1": "tolazamide", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "acarbose", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "sulfisoxazole", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of sulfisoxazole.", "severity": 2}
{"drug1": "Quinine", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "glipizide", "drug2": "atorvastatin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of atorvastatin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "mifepristone", "drug2": "metformin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "Quinine", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "tolazamide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "tolazamide", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "glipizide", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "acarbose", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "glimepiride", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "glipizide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "metformin", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "nateglinide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "nateglinide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "mifepristone", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "glipizide", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "tolazamide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "metformin", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "disopyramide", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "metformin", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "glyburide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "glyburide", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "glyburide", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "glipizide", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "pentamidine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of pentamidine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "Quinine", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "gliclazide", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "glyburide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "practolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "glimepiride", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "acarbose", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "acarbose", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "pentamidine", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "acarbose", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "carvedilol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of carvedilol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "nateglinide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "nateglinide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "tolazamide", "drug2": "timolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "acarbose", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "mifepristone", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "metformin", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "sulfamethoxazole", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of sulfamethoxazole.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "glyburide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of glyburide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "glipizide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "metformin", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Quinine", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "metformin", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "glimepiride", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "pentamidine", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "mifepristone", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "disopyramide", "drug2": "sulfisoxazole", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of sulfisoxazole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Quinine", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "glipizide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "sulfamethoxazole", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of sulfamethoxazole.", "severity": 2}
{"drug1": "glyburide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "glyburide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of glyburide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "sulfamethoxazole", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of sulfamethoxazole.", "severity": 2}
{"drug1": "gliclazide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Quinine", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "tolazamide", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Sunitinib", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of Sunitinib.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "metformin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "mifepristone", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of mifepristone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "acarbose", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "timolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "glipizide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "glipizide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "tolazamide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "metformin", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "gliclazide", "drug2": "atorvastatin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of atorvastatin.", "severity": 2}
{"drug1": "glipizide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "metformin", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Quinine", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "metformin", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "gliclazide", "drug2": "celiprolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of celiprolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "nateglinide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "glyburide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "glyburide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "metformin", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "gliclazide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of gliclazide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "tolbutamide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of tolbutamide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "metformin", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "pentamidine", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "glipizide", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "mifepristone", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "glyburide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of glyburide.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "sulfamethoxazole", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of sulfamethoxazole.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "acarbose", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "glipizide", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "carvedilol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of carvedilol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "acarbose", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "glyburide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "glyburide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "acarbose", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "glipizide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of glipizide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "voglibose", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "voglibose may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "BUPRANOLOL", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "BOPINDOLOL", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "glyburide", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Sunitinib", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of Sunitinib.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "gliclazide", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "acarbose", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "glyburide", "drug2": "pentamidine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of pentamidine.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "glipizide", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "pentamidine", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "tolazamide", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "Quinine", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "acarbose", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Arotinolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Arotinolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "carvedilol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of carvedilol.", "severity": 2}
{"drug1": "glipizide", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "mifepristone", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "metformin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "tolazamide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "disopyramide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "mifepristone", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "metformin", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "metformin", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "metformin", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "metformin", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "Quinine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "glipizide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of glipizide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "glyburide", "drug2": "clofibrate", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of clofibrate.", "severity": 2}
{"drug1": "metformin", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "oxprenolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of oxprenolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "glyburide", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "gliclazide", "drug2": "fenofibrate", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of fenofibrate.", "severity": 2}
{"drug1": "mifepristone", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "gliclazide", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "gemfibrozil", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of gemfibrozil.", "severity": 2}
{"drug1": "disopyramide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "acarbose", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "glyburide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "tolazamide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "glyburide", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "metformin", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "disopyramide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "Lanreotide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Repaglinide", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of Repaglinide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "gliclazide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "acarbose", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "acarbose", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "LEVOBUNOLOL", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "metoprolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of metoprolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "tolazamide", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "acarbose", "drug2": "selegiline", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of selegiline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "procarbazine", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of procarbazine.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "nateglinide", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of nateglinide.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Escitalopram", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of Escitalopram.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "metformin", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "acarbose", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "atorvastatin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of atorvastatin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "sotalol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of sotalol.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "fluvoxamine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of fluvoxamine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "acarbose", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "mifepristone", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "metformin", "drug2": "fluvoxamine", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of fluvoxamine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "acebutolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of acebutolol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "disopyramide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Vildagliptin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "mifepristone", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "nateglinide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "chlorpropamide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "Pasireotide may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Metipranolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Metipranolol.", "severity": 2}
{"drug1": "metformin", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "metformin", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "disopyramide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "acarbose", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "ROSOXACIN", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of ROSOXACIN.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "metformin", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "Quinine", "drug2": "moclobemide", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of moclobemide.", "severity": 2}
{"drug1": "glimepiride", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "glipizide", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "alprenolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of alprenolol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Octreotide", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Octreotide.", "severity": 2}
{"drug1": "glyburide", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "glyburide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "gliclazide", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "Dapagliflozin may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Quinine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Quinine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "miconazole", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of miconazole.", "severity": 2}
{"drug1": "gliclazide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "glipizide", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "glipizide", "drug2": "nadolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of nadolol.", "severity": 2}
{"drug1": "acarbose", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "oxymetholone", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of oxymetholone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "sulfadiazine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of sulfadiazine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Bevantolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Bevantolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "practolol", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Sitagliptin", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of Sitagliptin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Saxagliptin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Saxagliptin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "betaxolol", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of betaxolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Pioglitazone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Pioglitazone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Gemifloxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Gemifloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "practolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of practolol.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "fluvoxamine", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of fluvoxamine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Canagliflozin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Canagliflozin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "disopyramide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "metformin", "drug2": "nefazodone", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of nefazodone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "tolazamide", "drug2": "atenolol", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of atenolol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "propranolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of propranolol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "acarbose", "drug2": "venlafaxine", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of venlafaxine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Etofibrate", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Etofibrate.", "severity": 2}
{"drug1": "acarbose", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Empagliflozin", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of Empagliflozin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "nalidixic acid", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of nalidixic acid.", "severity": 2}
{"drug1": "glipizide", "drug2": "bezafibrate", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of bezafibrate.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "MIGLITOL", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of MIGLITOL.", "severity": 2}
{"drug1": "acarbose", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "tolazamide", "interaction_type": 9, "interaction_text": "Sunitinib may increase the hypoglycemic activities of tolazamide.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Trovafloxacin", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of Trovafloxacin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "acarbose", "drug2": "diflunisal", "interaction_type": 9, "interaction_text": "acarbose may increase the hypoglycemic activities of diflunisal.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "lipoic acid", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of lipoic acid.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "Canagliflozin may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "mifepristone may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "testosterone propionate", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of testosterone propionate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "aspirin", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of aspirin.", "severity": 2}
{"drug1": "Quinine", "drug2": "glimepiride", "interaction_type": 9, "interaction_text": "Quinine may increase the hypoglycemic activities of glimepiride.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "BISOPROLOL", "interaction_type": 9, "interaction_text": "Gliquidone may increase the hypoglycemic activities of BISOPROLOL.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Phenelzine", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Phenelzine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Gliquidone", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Gliquidone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Olsalazine", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Olsalazine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "glipizide", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "glimepiride", "drug2": "atorvastatin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of atorvastatin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Linagliptin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of Linagliptin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "glipizide", "drug2": "timolol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of timolol.", "severity": 2}
{"drug1": "glipizide", "drug2": "labetalol", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of labetalol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "methylene blue", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of methylene blue.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Toloxatone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Toloxatone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Pirlindole", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of Pirlindole.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Alogliptin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Alogliptin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "mesalamine", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of mesalamine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "sertraline", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of sertraline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "LEVOFLOXACIN", "interaction_type": 9, "interaction_text": "bromocriptine may increase the hypoglycemic activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "nateglinide", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Saxagliptin may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "glyburide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "rasagiline", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of rasagiline.", "severity": 2}
{"drug1": "glimepiride", "drug2": "AMPHETAMINE", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "glipizide", "drug2": "pargyline", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of pargyline.", "severity": 2}
{"drug1": "glimepiride", "drug2": "ESMOLOL", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of ESMOLOL.", "severity": 2}
{"drug1": "glipizide", "drug2": "OXANDROLONE", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of OXANDROLONE.", "severity": 2}
{"drug1": "glipizide", "drug2": "testosterone", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of testosterone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "paroxetine", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of paroxetine.", "severity": 2}
{"drug1": "glipizide", "drug2": "fluoxetine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of fluoxetine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "disopyramide", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of disopyramide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "acarbose", "interaction_type": 9, "interaction_text": "sulfadiazine may increase the hypoglycemic activities of acarbose.", "severity": 2}
{"drug1": "gliclazide", "drug2": "norfloxacin", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of norfloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "metformin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of metformin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Pefloxacin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Pefloxacin.", "severity": 2}
{"drug1": "glipizide", "drug2": "tranylcypromine", "interaction_type": 9, "interaction_text": "glipizide may increase the hypoglycemic activities of tranylcypromine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "tolbutamide may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Milnacipran", "interaction_type": 9, "interaction_text": "Alogliptin may increase the hypoglycemic activities of Milnacipran.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "fluoxymesterone", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of fluoxymesterone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "furazolidone", "interaction_type": 9, "interaction_text": "pentamidine may increase the hypoglycemic activities of furazolidone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Nebivolol", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Nebivolol.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "enoxacin", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of enoxacin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Vildagliptin", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of Vildagliptin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "voglibose", "interaction_type": 9, "interaction_text": "disopyramide may increase the hypoglycemic activities of voglibose.", "severity": 2}
{"drug1": "nateglinide", "drug2": "cinoxacin", "interaction_type": 9, "interaction_text": "nateglinide may increase the hypoglycemic activities of cinoxacin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "duloxetine", "interaction_type": 9, "interaction_text": "gliclazide may increase the hypoglycemic activities of duloxetine.", "severity": 2}
{"drug1": "metformin", "drug2": "citalopram", "interaction_type": 9, "interaction_text": "metformin may increase the hypoglycemic activities of citalopram.", "severity": 2}
{"drug1": "glimepiride", "drug2": "penbutolol", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of penbutolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "Miglustat", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of Miglustat.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "stanozolol", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of stanozolol.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "sulfisoxazole may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "glyburide", "drug2": "rosiglitazone", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of rosiglitazone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "methyltestosterone", "interaction_type": 9, "interaction_text": "sulfamethoxazole may increase the hypoglycemic activities of methyltestosterone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Levomilnacipran", "interaction_type": 9, "interaction_text": "chlorpropamide may increase the hypoglycemic activities of Levomilnacipran.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "BALSALAZIDE", "interaction_type": 9, "interaction_text": "MIGLITOL may increase the hypoglycemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "isocarboxazid", "interaction_type": 9, "interaction_text": "Repaglinide may increase the hypoglycemic activities of isocarboxazid.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Gatifloxacin", "interaction_type": 9, "interaction_text": "rosiglitazone may increase the hypoglycemic activities of Gatifloxacin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Fenofibric acid", "interaction_type": 9, "interaction_text": "glimepiride may increase the hypoglycemic activities of Fenofibric acid.", "severity": 2}
{"drug1": "tolazamide", "drug2": "sparfloxacin", "interaction_type": 9, "interaction_text": "tolazamide may increase the hypoglycemic activities of sparfloxacin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 9, "interaction_text": "Empagliflozin may increase the hypoglycemic activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "salicylic acid", "interaction_type": 9, "interaction_text": "Sitagliptin may increase the hypoglycemic activities of salicylic acid.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "fleroxacin", "interaction_type": 9, "interaction_text": "Pioglitazone may increase the hypoglycemic activities of fleroxacin.", "severity": 2}
{"drug1": "glyburide", "drug2": "CARTEOLOL", "interaction_type": 9, "interaction_text": "glyburide may increase the hypoglycemic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "diazoxide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of diazoxide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "tibolone", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of tibolone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "enalapril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of enalapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "methyldopa", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of methyldopa.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "chlorthalidone", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "alprenolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of alprenolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "BISOPROLOL", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Pentolinium", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Pentolinium.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Treprostinil", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Treprostinil.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Silodosin", "interaction_type": 10, "interaction_text": "alfuzosin may increase the antihypertensive activities of Silodosin.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Bimatoprost", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "dorzolamide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of dorzolamide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "rescinnamine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of rescinnamine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Bretylium", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Bretylium.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Ambrisentan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "trandolapril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of trandolapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "felodipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of felodipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "GUANFACINE", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "trichlormethiazide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "METYROSINE", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of METYROSINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "GUANETHIDINE", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "TRIMETHAPHAN", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "quinapril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of quinapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "chlorothiazide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of chlorothiazide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "phenoxybenzamine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nadolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of nadolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "benazepril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of benazepril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nimodipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of nimodipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "metoprolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of metoprolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "propranolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of propranolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "GUANFACINE", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "clonidine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of clonidine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Bretylium", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Bretylium.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "diltiazem", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of diltiazem.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Nitroprusside", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Avanafil", "drug2": "reserpine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of reserpine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "BISOPROLOL", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "sildenafil", "drug2": "celiprolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of celiprolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "epoprostenol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of epoprostenol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "nisoldipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of nisoldipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Travoprost", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Travoprost.", "severity": 2}
{"drug1": "sildenafil", "drug2": "propranolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of propranolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nisoldipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of nisoldipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "manidipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of manidipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "xylometazoline", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of xylometazoline.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Efonidipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Efonidipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Nitroprusside", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Udenafil", "drug2": "phentolamine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of phentolamine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "MOEXIPRIL", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Remikiren", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Remikiren.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nilvadipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of nilvadipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "tibolone", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of tibolone.", "severity": 2}
{"drug1": "Udenafil", "drug2": "MOXONIDINE", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "carvedilol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of carvedilol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Olmesartan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Olmesartan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "timolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of timolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Treprostinil", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Treprostinil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Eprosartan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Eprosartan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Unoprostone", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Unoprostone.", "severity": 2}
{"drug1": "Udenafil", "drug2": "celiprolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of celiprolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Travoprost", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Travoprost.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Lercanidipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Debrisoquine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Debrisoquine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "fenoldopam", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of fenoldopam.", "severity": 2}
{"drug1": "Udenafil", "drug2": "metolazone", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of metolazone.", "severity": 2}
{"drug1": "Udenafil", "drug2": "CARTEOLOL", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "mecamylamine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of mecamylamine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "metolazone", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of metolazone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "betaxolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of betaxolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "fosinopril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of fosinopril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "felodipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of felodipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "hydralazine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of hydralazine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Bethanidine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Bethanidine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "chlorothiazide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "quinapril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of quinapril.", "severity": 2}
{"drug1": "Avanafil", "drug2": "betaxolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of betaxolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "cilazapril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of cilazapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "irbesartan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of irbesartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Spirapril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Spirapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Nebivolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Nebivolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Sitaxsentan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "rescinnamine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of rescinnamine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "atenolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of atenolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Bimatoprost", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Bimatoprost.", "severity": 2}
{"drug1": "sildenafil", "drug2": "pargyline", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of pargyline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "GUANFACINE", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of GUANFACINE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Metipranolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Metipranolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "xylometazoline", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of xylometazoline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "BISOPROLOL", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Aliskiren", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Aliskiren.", "severity": 2}
{"drug1": "sildenafil", "drug2": "BISOPROLOL", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "latanoprost", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of latanoprost.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "betaxolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of betaxolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "penbutolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of penbutolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nitrendipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of nitrendipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Metipranolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Metipranolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "oxprenolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of oxprenolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "TRIMETHAPHAN", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Udenafil", "drug2": "diazoxide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of diazoxide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "diltiazem", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of diltiazem.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Bimatoprost", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nicardipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of nicardipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "MOXONIDINE", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "atenolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of atenolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "epoprostenol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of epoprostenol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "guanabenz", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of guanabenz.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "bepridil", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of bepridil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "pargyline", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of pargyline.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "enalapril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of enalapril.", "severity": 2}
{"drug1": "sildenafil", "drug2": "fenoldopam", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of fenoldopam.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "DESERPIDINE", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "indapamide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of indapamide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "GUANADREL", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of GUANADREL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "pargyline", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of pargyline.", "severity": 2}
{"drug1": "Udenafil", "drug2": "minoxidil", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of minoxidil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "cilazapril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of cilazapril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "captopril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of captopril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "diltiazem", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of diltiazem.", "severity": 2}
{"drug1": "brimonidine", "drug2": "guanabenz", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of guanabenz.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "acebutolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of acebutolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nitrendipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of nitrendipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nicardipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of nicardipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Unoprostone", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Unoprostone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "polythiazide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of polythiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "irbesartan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of irbesartan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "benazepril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of benazepril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "trichlormethiazide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "penbutolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of penbutolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "pargyline", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of pargyline.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Nitroprusside", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Avanafil", "drug2": "fosinopril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of fosinopril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "fosinopril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of fosinopril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "reserpine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of reserpine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "mecamylamine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of mecamylamine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "latanoprost", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of latanoprost.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nisoldipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of nisoldipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Unoprostone", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Unoprostone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Eprosartan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Eprosartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Debrisoquine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nisoldipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of nisoldipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "lisinopril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of lisinopril.", "severity": 2}
{"drug1": "sildenafil", "drug2": "reserpine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of reserpine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "quinapril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of quinapril.", "severity": 2}
{"drug1": "Avanafil", "drug2": "chlorothiazide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of chlorothiazide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "celiprolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of celiprolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "phenoxybenzamine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "phenoxybenzamine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nimodipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of nimodipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nisoldipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of nisoldipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "chlorthalidone", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Udenafil", "drug2": "xylometazoline", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of xylometazoline.", "severity": 2}
{"drug1": "brimonidine", "drug2": "fosinopril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of fosinopril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Terlipressin", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Terlipressin.", "severity": 2}
{"drug1": "brimonidine", "drug2": "tibolone", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of tibolone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nimodipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of nimodipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "phentolamine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of phentolamine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "MOEXIPRIL", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "sildenafil", "drug2": "latanoprost", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of latanoprost.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Olmesartan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Olmesartan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Pentolinium", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Pentolinium.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Macitentan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Macitentan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "isradipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of isradipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Pentolinium", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Pentolinium.", "severity": 2}
{"drug1": "brimonidine", "drug2": "hydrochlorothiazide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "alprenolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of alprenolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Nebivolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Nebivolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nicardipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of nicardipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Lofexidine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Lofexidine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "propranolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of propranolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "guanabenz", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of guanabenz.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "MOXONIDINE", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "bepridil", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of bepridil.", "severity": 2}
{"drug1": "brimonidine", "drug2": "GUANADREL", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of GUANADREL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "epoprostenol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of epoprostenol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "pargyline", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of pargyline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "clonidine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of clonidine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "propranolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of propranolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "tolazoline", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of tolazoline.", "severity": 2}
{"drug1": "sildenafil", "drug2": "GUANETHIDINE", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "chlorthalidone", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Pentolinium", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Pentolinium.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Eprosartan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Eprosartan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "dorzolamide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of dorzolamide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "tibolone", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of tibolone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Unoprostone", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Unoprostone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "alprenolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of alprenolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "DESERPIDINE", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "bepridil", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of bepridil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "acebutolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of acebutolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "epoprostenol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of epoprostenol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "captopril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of captopril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Lofexidine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Lofexidine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nitrendipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of nitrendipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "isradipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of isradipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Olmesartan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Olmesartan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "BISOPROLOL", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "BUPRANOLOL", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Lercanidipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "hydralazine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of hydralazine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "brimonidine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of brimonidine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "clonidine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of clonidine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "CARTEOLOL", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "propranolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of propranolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "nilvadipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of nilvadipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Olmesartan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Olmesartan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "isradipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of isradipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Treprostinil", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Treprostinil.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "timolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of timolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "indapamide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of indapamide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "timolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of timolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "fenoldopam", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of fenoldopam.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "fenoldopam", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of fenoldopam.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Pentolinium", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Pentolinium.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "indapamide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of indapamide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Torasemide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Torasemide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Bethanidine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Bethanidine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Telmisartan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Telmisartan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "guanabenz", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of guanabenz.", "severity": 2}
{"drug1": "sildenafil", "drug2": "clonidine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of clonidine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "methyldopa", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of methyldopa.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nicardipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of nicardipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Telmisartan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Telmisartan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "hydroflumethiazide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Silodosin", "interaction_type": 10, "interaction_text": "TAMSULOSIN may increase the antihypertensive activities of Silodosin.", "severity": 2}
{"drug1": "Udenafil", "drug2": "lisinopril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of lisinopril.", "severity": 2}
{"drug1": "Avanafil", "drug2": "NICORANDIL", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of NICORANDIL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "minoxidil", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of minoxidil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nimodipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of nimodipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "oxprenolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of oxprenolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "prazosin", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of prazosin.", "severity": 2}
{"drug1": "brimonidine", "drug2": "labetalol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of labetalol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "MOEXIPRIL", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "phentolamine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of phentolamine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "rescinnamine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of rescinnamine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "doxazosin", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of doxazosin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "timolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of timolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Treprostinil", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Treprostinil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "mecamylamine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of mecamylamine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "latanoprost", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of latanoprost.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Lofexidine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Lofexidine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "phentolamine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of phentolamine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "alprenolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of alprenolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "dorzolamide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of dorzolamide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "nitrendipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of nitrendipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "PERINDOPRIL", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "sildenafil", "drug2": "penbutolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of penbutolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Candesartan cilexetil", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Sitaxsentan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Enalaprilat", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Enalaprilat.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Sitaxsentan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "acebutolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of acebutolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Eprosartan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Eprosartan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "captopril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of captopril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nadolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of nadolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "guanabenz", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of guanabenz.", "severity": 2}
{"drug1": "Udenafil", "drug2": "tibolone", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of tibolone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "penbutolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of penbutolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Metipranolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Metipranolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nicardipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of nicardipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "penbutolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of penbutolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "oxprenolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of oxprenolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Lofexidine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Lofexidine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Lofexidine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Lofexidine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "cyclothiazide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "GUANADREL", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of GUANADREL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Metipranolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Metipranolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nadolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of nadolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "benazepril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of benazepril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "manidipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of manidipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "valsartan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of valsartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Olmesartan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Olmesartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "ramipril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of ramipril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "isradipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of isradipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Lacidipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Lacidipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "hydrochlorothiazide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "trichlormethiazide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "felodipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of felodipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "irbesartan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of irbesartan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "atenolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of atenolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Nitroprusside", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Avanafil", "drug2": "CARTEOLOL", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "atenolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of atenolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Lercanidipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Aliskiren", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Aliskiren.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Telmisartan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Telmisartan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "phenoxybenzamine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "polythiazide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of polythiazide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "methyldopa", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of methyldopa.", "severity": 2}
{"drug1": "Avanafil", "drug2": "chlorthalidone", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "betaxolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of betaxolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "brimonidine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of brimonidine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Remikiren", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Remikiren.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Bethanidine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Bethanidine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "METYROSINE", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of METYROSINE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "cilazapril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of cilazapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Spirapril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Spirapril.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Bimatoprost", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "metolazone", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of metolazone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Candesartan cilexetil", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "brimonidine", "drug2": "xylometazoline", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of xylometazoline.", "severity": 2}
{"drug1": "Avanafil", "drug2": "PERINDOPRIL", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "CARTEOLOL", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Bosentan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Bosentan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "phentolamine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of phentolamine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "dorzolamide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of dorzolamide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Lercanidipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "MOEXIPRIL", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "losartan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of losartan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Travoprost", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Travoprost.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Nebivolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Nebivolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Debrisoquine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Nitroprusside", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "celiprolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of celiprolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Nebivolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Nebivolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "GUANFACINE", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "hydroflumethiazide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "losartan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of losartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "hydroflumethiazide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "oxprenolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of oxprenolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "metoprolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of metoprolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "polythiazide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of polythiazide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Terlipressin", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Terlipressin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "hydrochlorothiazide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Bretylium", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Bretylium.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Pentolinium", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Pentolinium.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Nebivolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Nebivolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "metoprolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of metoprolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Eprosartan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Eprosartan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "ramipril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of ramipril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "BUPRANOLOL", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Enalaprilat", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nilvadipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of nilvadipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "valsartan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of valsartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "polythiazide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of polythiazide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "celiprolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of celiprolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Debrisoquine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Riociguat", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Riociguat.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "DESERPIDINE", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "minoxidil", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of minoxidil.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "quinapril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of quinapril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "chlorothiazide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Bethanidine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Bethanidine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Eprosartan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Eprosartan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Torasemide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Torasemide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Unoprostone", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Unoprostone.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Remikiren", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Remikiren.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Telmisartan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Telmisartan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "phenoxybenzamine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "hydralazine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of hydralazine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "NICORANDIL", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "GUANETHIDINE", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Lacidipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Lacidipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Efonidipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Efonidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Ambrisentan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "enalapril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of enalapril.", "severity": 2}
{"drug1": "Avanafil", "drug2": "TRIMETHAPHAN", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "chlorthalidone", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "diazoxide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of diazoxide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nitrendipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of nitrendipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "cyclothiazide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of cyclothiazide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "manidipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of manidipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "fosinopril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of fosinopril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "clonidine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of clonidine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "valsartan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of valsartan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "diazoxide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of diazoxide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "irbesartan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of irbesartan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "TRIMETHAPHAN", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Udenafil", "drug2": "ramipril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of ramipril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "trandolapril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of trandolapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "tibolone", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of tibolone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "trichlormethiazide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Treprostinil", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Treprostinil.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "hydralazine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of hydralazine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "trandolapril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of trandolapril.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Sitaxsentan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "reserpine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of reserpine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "timolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of timolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Efonidipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Efonidipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "GUANETHIDINE", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "PERINDOPRIL", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "tolazoline", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of tolazoline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Candesartan cilexetil", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Riociguat", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Riociguat.", "severity": 2}
{"drug1": "brimonidine", "drug2": "MOXONIDINE", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Sitaxsentan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "PERINDOPRIL", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nisoldipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of nisoldipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Unoprostone", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Unoprostone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "rescinnamine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of rescinnamine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Enalaprilat", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Avanafil", "drug2": "GUANADREL", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of GUANADREL.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "GUANADREL", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of GUANADREL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Macitentan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Macitentan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "diltiazem", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of diltiazem.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Terlipressin", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Terlipressin.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "trandolapril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of trandolapril.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Terlipressin", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Terlipressin.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "latanoprost", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of latanoprost.", "severity": 2}
{"drug1": "brimonidine", "drug2": "TRIMETHAPHAN", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "brimonidine", "drug2": "enalapril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of enalapril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "felodipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of felodipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "minoxidil", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of minoxidil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "diltiazem", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of diltiazem.", "severity": 2}
{"drug1": "brimonidine", "drug2": "indapamide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of indapamide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "irbesartan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of irbesartan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "irbesartan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of irbesartan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "xylometazoline", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of xylometazoline.", "severity": 2}
{"drug1": "sildenafil", "drug2": "felodipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of felodipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "trichlormethiazide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Bimatoprost", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Bimatoprost.", "severity": 2}
{"drug1": "sildenafil", "drug2": "BUPRANOLOL", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "rescinnamine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of rescinnamine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "NICORANDIL", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "losartan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of losartan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "hydroflumethiazide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "BUPRANOLOL", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Metipranolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Metipranolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "MOXONIDINE", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Remikiren", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Remikiren.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Lacidipine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Lacidipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nadolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of nadolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Bretylium", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Bretylium.", "severity": 2}
{"drug1": "Udenafil", "drug2": "penbutolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of penbutolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "betaxolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of betaxolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "betaxolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of betaxolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "oxprenolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of oxprenolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "xylometazoline", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of xylometazoline.", "severity": 2}
{"drug1": "Avanafil", "drug2": "rescinnamine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of rescinnamine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Debrisoquine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "phenoxybenzamine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "NICORANDIL", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of NICORANDIL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Macitentan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Macitentan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Torasemide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Torasemide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Aliskiren", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Aliskiren.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Sitaxsentan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "cyclothiazide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Terlipressin", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Terlipressin.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nadolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of nadolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "NICORANDIL", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Macitentan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Macitentan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "hydrochlorothiazide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Riociguat", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Riociguat.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Ambrisentan", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Ambrisentan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Ambrisentan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Bretylium", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Bretylium.", "severity": 2}
{"drug1": "Udenafil", "drug2": "atenolol", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of atenolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Terlipressin", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Terlipressin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "tolazoline", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of tolazoline.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Nitroprusside", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Nitroprusside.", "severity": 2}
{"drug1": "brimonidine", "drug2": "cyclothiazide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Lercanidipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "oxprenolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of oxprenolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Enalaprilat", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "CARTEOLOL", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "metolazone", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of metolazone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "MOEXIPRIL", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "phentolamine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of phentolamine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "losartan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of losartan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "hydroflumethiazide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "hydroflumethiazide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "TAMSULOSIN", "interaction_type": 10, "interaction_text": "alfuzosin may increase the antihypertensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "terazosin", "interaction_type": 10, "interaction_text": "alfuzosin may increase the antihypertensive activities of terazosin.", "severity": 2}
{"drug1": "Udenafil", "drug2": "losartan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of losartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "benazepril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of benazepril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Metipranolol", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Metipranolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Aliskiren", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Aliskiren.", "severity": 2}
{"drug1": "sildenafil", "drug2": "METYROSINE", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of METYROSINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "BUPRANOLOL", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Candesartan cilexetil", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "brimonidine", "drug2": "GUANFACINE", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of GUANFACINE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "GUANADREL", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of GUANADREL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "GUANFACINE", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "benazepril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of benazepril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "minoxidil", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of minoxidil.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "trichlormethiazide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "felodipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of felodipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "alprenolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of alprenolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "cyclothiazide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "METYROSINE", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of METYROSINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Bimatoprost", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Bimatoprost.", "severity": 2}
{"drug1": "brimonidine", "drug2": "dorzolamide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of dorzolamide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Macitentan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Macitentan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "enalapril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of enalapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "MOXONIDINE", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "valsartan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of valsartan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "metolazone", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of metolazone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Olmesartan", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Olmesartan.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Ambrisentan", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "ramipril", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of ramipril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "isradipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of isradipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "tolazoline", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of tolazoline.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "atenolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of atenolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "epoprostenol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of epoprostenol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "bepridil", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of bepridil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "metoprolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of metoprolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Enalaprilat", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Enalaprilat.", "severity": 2}
{"drug1": "brimonidine", "drug2": "DESERPIDINE", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "chlorthalidone", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of chlorthalidone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "losartan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of losartan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "fenoldopam", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of fenoldopam.", "severity": 2}
{"drug1": "sildenafil", "drug2": "hydralazine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of hydralazine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "indapamide", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of indapamide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "valsartan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of valsartan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "valsartan", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of valsartan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Travoprost", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Travoprost.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "ramipril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of ramipril.", "severity": 2}
{"drug1": "Avanafil", "drug2": "celiprolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of celiprolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "bepridil", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of bepridil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Debrisoquine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Lacidipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Lacidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "brimonidine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of brimonidine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "lisinopril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of lisinopril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "brimonidine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of brimonidine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "reserpine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of reserpine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "manidipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of manidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "acebutolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of acebutolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Aliskiren", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Aliskiren.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nilvadipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of nilvadipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Travoprost", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Travoprost.", "severity": 2}
{"drug1": "sildenafil", "drug2": "nadolol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of nadolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Torasemide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Torasemide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Efonidipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Efonidipine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "hydrochlorothiazide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "reserpine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of reserpine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Spirapril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of Spirapril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "quinapril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of quinapril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "chlorothiazide", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "methyldopa", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of methyldopa.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "PERINDOPRIL", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Telmisartan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Telmisartan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "tolazoline", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of tolazoline.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Candesartan cilexetil", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Lacidipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Lacidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Efonidipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Efonidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "manidipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of manidipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "acebutolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of acebutolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "captopril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of captopril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Lofexidine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Lofexidine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Bretylium", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Bretylium.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nitrendipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of nitrendipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Remikiren", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Remikiren.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Torasemide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Torasemide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Bethanidine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Bethanidine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "minoxidil", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of minoxidil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "acebutolol", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of acebutolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "captopril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of captopril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Spirapril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Spirapril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "alprenolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of alprenolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "cilazapril", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of cilazapril.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "dorzolamide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of dorzolamide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "lisinopril", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of lisinopril.", "severity": 2}
{"drug1": "Avanafil", "drug2": "brimonidine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of brimonidine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "cyclothiazide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of cyclothiazide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Treprostinil", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of Treprostinil.", "severity": 2}
{"drug1": "brimonidine", "drug2": "timolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of timolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Travoprost", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Travoprost.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "polythiazide", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of polythiazide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "clonidine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of clonidine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "metoprolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of metoprolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nilvadipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of nilvadipine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "propranolol", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of propranolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Telmisartan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Telmisartan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "methyldopa", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of methyldopa.", "severity": 2}
{"drug1": "sildenafil", "drug2": "chlorothiazide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Ambrisentan", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "diazoxide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of diazoxide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "TRIMETHAPHAN", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Bethanidine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Bethanidine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Nebivolol", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of Nebivolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Torasemide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Torasemide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Aliskiren", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Aliskiren.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "BUPRANOLOL", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "latanoprost", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of latanoprost.", "severity": 2}
{"drug1": "Avanafil", "drug2": "mecamylamine", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of mecamylamine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "CARTEOLOL", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Macitentan", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Macitentan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "metolazone", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of metolazone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Lercanidipine", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "METYROSINE", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of METYROSINE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Candesartan cilexetil", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "tolazoline", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of tolazoline.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nilvadipine", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of nilvadipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Spirapril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Spirapril.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "GUANETHIDINE", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "mecamylamine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of mecamylamine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "cilazapril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of cilazapril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "hydralazine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of hydralazine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "GUANETHIDINE", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "manidipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of manidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "epoprostenol", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of epoprostenol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Lacidipine", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of Lacidipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Efonidipine", "interaction_type": 10, "interaction_text": "Vardenafil may increase the antihypertensive activities of Efonidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "bepridil", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of bepridil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "polythiazide", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of polythiazide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "hydrochlorothiazide", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "DESERPIDINE", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "indapamide", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of indapamide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "lisinopril", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of lisinopril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "methyldopa", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of methyldopa.", "severity": 2}
{"drug1": "Avanafil", "drug2": "fenoldopam", "interaction_type": 10, "interaction_text": "Avanafil may increase the antihypertensive activities of fenoldopam.", "severity": 2}
{"drug1": "sildenafil", "drug2": "guanabenz", "interaction_type": 10, "interaction_text": "sildenafil may increase the antihypertensive activities of guanabenz.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "BISOPROLOL", "interaction_type": 10, "interaction_text": "Tadalafil may increase the antihypertensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "DESERPIDINE", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "trandolapril", "interaction_type": 10, "interaction_text": "Udenafil may increase the antihypertensive activities of trandolapril.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nimodipine", "interaction_type": 10, "interaction_text": "brimonidine may increase the antihypertensive activities of nimodipine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with TROLEANDOMYCIN resulting in a loss in efficacy.", "severity": 2}
{"drug1": "fluconazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with fluconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with pentobarbital resulting in a loss in efficacy.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with SERATRODAST resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Imatinib", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Imatinib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with nefazodone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with CYCLACILLIN resulting in a loss in efficacy.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with methoxsalen resulting in a loss in efficacy.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with fluvoxamine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "OXCARBAZEPINE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of OXCARBAZEPINE can be reduced when OXCARBAZEPINE is used in combination with phenobarbital resulting in a loss in efficacy.", "severity": 2}
{"drug1": "methadone", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with methadone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Fosamprenavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with nelfinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Lopinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifampicin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Crizotinib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Propacetamol", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Propacetamol can be reduced when Propacetamol is used in combination with Fosphenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "mitotane", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with mitotane resulting in a loss in efficacy.", "severity": 2}
{"drug1": "4-Methylpyrazole", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with 4-Methylpyrazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with ETHYNODIOL DIACETATE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with Cinacalcet resulting in a loss in efficacy.", "severity": 2}
{"drug1": "sildenafil", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with sildenafil resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Voriconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Dienogest resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with nevirapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with itraconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Olaparib", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Olaparib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with RUCAPARIB resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with ticlopidine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with clotrimazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with RANOLAZINE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with nelfinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with bacampicillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nicotine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with nicotine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "citalopram", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with citalopram resulting in a loss in efficacy.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with pentobarbital resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with ketoconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "OXCARBAZEPINE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of OXCARBAZEPINE can be reduced when OXCARBAZEPINE is used in combination with carbamazepine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Lorcaserin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with amiodarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with RANOLAZINE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Fosphenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with DESOGESTREL resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with clarithromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with ketoconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "haloperidol", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with haloperidol resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with Lopinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "methicillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with methicillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Posaconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with GESTODENE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with fluvoxamine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with venlafaxine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Ziprasidone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Propacetamol", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Propacetamol can be reduced when Propacetamol is used in combination with phenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Posaconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "nelfinavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of nelfinavir can be reduced when nelfinavir is used in combination with pantoprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Tesamorelin", "drug2": "CORTISONE ACETATE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of CORTISONE ACETATE can be reduced when CORTISONE ACETATE is used in combination with Tesamorelin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Dronedarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with amiodarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with RUCAPARIB resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with ketoconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Telaprevir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "efavirenz", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with efavirenz resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with nelfinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with Midostaurin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with clotrimazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Medroxyprogesterone acetate resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Delavirdine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Voriconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with isoniazid resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Atomoxetine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with clotrimazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Darunavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Bortezomib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nefazodone", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with nefazodone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Lumefantrine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clomiphene", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with clomiphene resulting in a loss in efficacy.", "severity": 2}
{"drug1": "isradipine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with isradipine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amiodarone", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of amiodarone can be reduced when amiodarone is used in combination with Rifampicin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Voriconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Delavirdine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "desipramine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with desipramine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "indinavir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with indinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with Tazobactam resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Cobicistat resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Darunavir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Darunavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with tranylcypromine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "primidone", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of primidone can be reduced when primidone is used in combination with Levomefolic acid resulting in a loss in efficacy.", "severity": 2}
{"drug1": "cimetidine", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with cimetidine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Telithromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Levonorgestrel resulting in a loss in efficacy.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with diltiazem resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with RUCAPARIB resulting in a loss in efficacy.", "severity": 2}
{"drug1": "indinavir", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with indinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with itraconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with RIFABUTIN resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Cobicistat resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Retigabine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Quinine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Quinine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Panobinostat resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Idelalisib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "indinavir", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with indinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with nevirapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with TICARCILLIN resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with amiodarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Telaprevir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Norelgestromin", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Norelgestromin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Atazanavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Isavuconazonium resulting in a loss in efficacy.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with fluoxetine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Conivaptan resulting in a loss in efficacy.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with buprenorphine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with carbamazepine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with pilocarpine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with RIFAPENTINE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Posaconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with amoxicillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "imipramine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with imipramine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with Dothiepin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "penicillin g", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with penicillin g resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with clofibrate resulting in a loss in efficacy.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with gemfibrozil resulting in a loss in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with isoniazid resulting in a loss in efficacy.", "severity": 2}
{"drug1": "oxacillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with oxacillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with phenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "paroxetine", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with paroxetine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "bupropion", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with bupropion resulting in a loss in efficacy.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with dexlansoprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Tesamorelin", "drug2": "prednisone", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of prednisone can be reduced when prednisone is used in combination with Tesamorelin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with amiodarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ropinirole", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with ropinirole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "nelfinavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of nelfinavir can be reduced when nelfinavir is used in combination with lansoprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with Flucloxacillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with ketoconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with Penicillin G benzathine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "primidone", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with primidone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with nevirapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "erythromycin", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with erythromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with clotrimazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clomipramine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with clomipramine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "desipramine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with desipramine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Rolapitant resulting in a loss in efficacy.", "severity": 2}
{"drug1": "primidone", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with primidone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with PENICILLIN G PROCAINE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with Pivmecillinam resulting in a loss in efficacy.", "severity": 2}
{"drug1": "moclobemide", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with moclobemide resulting in a loss in efficacy.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with betaxolol resulting in a loss in efficacy.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with NORGESTIMATE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenytoin", "drug2": "albendazole", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of albendazole can be reduced when albendazole is used in combination with phenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Voriconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Telithromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with isoniazid resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with ketoconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Dabigatran etexilate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be reduced when Dabigatran etexilate is used in combination with dexlansoprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with cyclosporin A resulting in a loss in efficacy.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with tranylcypromine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clemastine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with clemastine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with ETONOGESTREL resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "tegafur", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tegafur can be reduced when tegafur is used in combination with amiodarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with ketoconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Telaprevir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Artemether", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Artemether resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with ELIGLUSTAT resulting in a loss in efficacy.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Fosaprepitant", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosaprepitant can be reduced when Fosaprepitant is used in combination with paroxetine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Dabigatran etexilate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be reduced when Dabigatran etexilate is used in combination with Esomeprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "albendazole", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of albendazole can be reduced when albendazole is used in combination with carbamazepine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "methimazole", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with methimazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nicardipine", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with nicardipine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with sulfisoxazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "nelfinavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of nelfinavir can be reduced when nelfinavir is used in combination with dexlansoprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "sertraline", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with sertraline resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with RIFABUTIN resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with nelfinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "miconazole", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with miconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nelfinavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of nelfinavir can be reduced when nelfinavir is used in combination with nevirapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "topiramate", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with topiramate resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Eslicarbazepine acetate resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Enzalutamide resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with clarithromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenytoin", "drug2": "OXCARBAZEPINE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of OXCARBAZEPINE can be reduced when OXCARBAZEPINE is used in combination with phenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with ticlopidine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Armodafinil resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with ranitidine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "OXCARBAZEPINE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of OXCARBAZEPINE can be reduced when OXCARBAZEPINE is used in combination with Fosphenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with nevirapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Abiraterone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Lumacaftor resulting in a loss in efficacy.", "severity": 2}
{"drug1": "quinidine", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with quinidine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "chloroquine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with chloroquine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with SULBACTAM resulting in a loss in efficacy.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "nelfinavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of nelfinavir can be reduced when nelfinavir is used in combination with rabeprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with nevirapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Bortezomib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with lansoprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with MEZLOCILLIN resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Boceprevir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Boceprevir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with diethylstilbestrol resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with phenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with Pivampicillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with SAQUINAVIR resulting in a loss in efficacy.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with rabeprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "tegafur", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tegafur can be reduced when tegafur is used in combination with clotrimazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with AMPHETAMINE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with efavirenz resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clozapine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with clozapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Luliconazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Luliconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Nilotinib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Lopinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with lovastatin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with pantoprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Atazanavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with promazine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with dihydroergotamine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with phenobarbital resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Mirabegron resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Dexfenfluramine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with phenobarbital resulting in a loss in efficacy.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with tranylcypromine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "duloxetine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with duloxetine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with ticlopidine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "celecoxib", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with celecoxib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with RIFAPENTINE resulting in a loss in efficacy.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with dexamethasone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Telithromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "omeprazole", "drug2": "nelfinavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of nelfinavir can be reduced when nelfinavir is used in combination with omeprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "indinavir", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with indinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Drospirenone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nicardipine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with nicardipine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with rosiglitazone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "letrozole", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with letrozole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Vitamin D3 resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with phenobarbital resulting in a loss in efficacy.", "severity": 2}
{"drug1": "menadione", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with menadione resulting in a loss in efficacy.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with fluoxetine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "manidipine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with manidipine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nafcillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with nafcillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Dabigatran etexilate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be reduced when Dabigatran etexilate is used in combination with rabeprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with SAQUINAVIR resulting in a loss in efficacy.", "severity": 2}
{"drug1": "piperacillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with piperacillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Fosamprenavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with norgestrel resulting in a loss in efficacy.", "severity": 2}
{"drug1": "azlocillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with azlocillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with chloramphenicol resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Nilotinib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Zucapsaicin", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Zucapsaicin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with VERAPAMIL resulting in a loss in efficacy.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with diphenhydramine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Boceprevir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Lumacaftor resulting in a loss in efficacy.", "severity": 2}
{"drug1": "memantine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with memantine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "sertraline", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with sertraline resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Cobicistat resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "nelfinavir", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of nelfinavir can be reduced when nelfinavir is used in combination with Esomeprazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clemastine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with clemastine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "indinavir", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with indinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ritonavir", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with ritonavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "azelastine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with azelastine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Isavuconazonium", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with carbamazepine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with clarithromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nicotine", "drug2": "tegafur", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tegafur can be reduced when tegafur is used in combination with nicotine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Abiraterone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Atomoxetine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifampicin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "fluconazole", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with fluconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "efavirenz", "drug2": "buprenorphine", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of buprenorphine can be reduced when buprenorphine is used in combination with efavirenz resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with nilvadipine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "metyrapone", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with metyrapone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "cimetidine", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with cimetidine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "methadone", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with methadone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Rifampicin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "itraconazole", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with itraconazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lobeglitazone", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Lobeglitazone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Idelalisib resulting in a loss in efficacy.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with venlafaxine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "sulfaphenazole", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with sulfaphenazole resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with amiodarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with cloxacillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with Atazanavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Prasugrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Darunavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "citalopram", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with citalopram resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with nefazodone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "terbinafine", "drug2": "HYDROCODONE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of HYDROCODONE can be reduced when HYDROCODONE is used in combination with terbinafine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with azithromycin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with nevirapine resulting in a loss in efficacy.", "severity": 2}
{"drug1": "penicillin v", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with penicillin v resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Artemether", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Fosphenytoin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Imatinib", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Imatinib can be reduced when Imatinib is used in combination with gemfibrozil resulting in a loss in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "ifosfamide", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be reduced when ifosfamide is used in combination with doxycycline resulting in a loss in efficacy.", "severity": 2}
{"drug1": "ampicillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with ampicillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "modafinil", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with modafinil resulting in a loss in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with norfloxacin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "efavirenz", "drug2": "NORGESTIMATE", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of NORGESTIMATE can be reduced when NORGESTIMATE is used in combination with efavirenz resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Dronedarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Ziprasidone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "albendazole", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of albendazole can be reduced when albendazole is used in combination with phenobarbital resulting in a loss in efficacy.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "mycophenolic acid", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of mycophenolic acid can be reduced when mycophenolic acid is used in combination with dicloxacillin resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "tamoxifen", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of tamoxifen can be reduced when tamoxifen is used in combination with Cobicistat resulting in a loss in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Artesunate", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with amiodarone resulting in a loss in efficacy.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with SAQUINAVIR resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Ticagrelor", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Lopinavir resulting in a loss in efficacy.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "clopidogrel", "interaction_type": 11, "interaction_text": "The serum concentration of the active metabolites of clopidogrel can be reduced when clopidogrel is used in combination with Vitamin D3 resulting in a loss in efficacy.", "severity": 2}
{"drug1": "phenindione", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "phenindione", "drug2": "propylthiouracil", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of propylthiouracil.", "severity": 2}
{"drug1": "warfarin", "drug2": "Norelgestromin", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Norelgestromin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "methimazole", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of methimazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "potassium iodide", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of potassium iodide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "nafcillin", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of nafcillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "potassium iodide", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of potassium iodide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Dienogest", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Dienogest.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Medroxyprogesterone acetate", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "phenindione", "drug2": "NORGESTIMATE", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of NORGESTIMATE.", "severity": 2}
{"drug1": "phenindione", "drug2": "norgestrel", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of norgestrel.", "severity": 2}
{"drug1": "phenindione", "drug2": "Carbimazole", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Carbimazole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "azathioprine", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of azathioprine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "warfarin", "drug2": "estramustine", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of estramustine.", "severity": 2}
{"drug1": "warfarin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "phenindione", "drug2": "Drospirenone", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Drospirenone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "phytonadione", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of phytonadione.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "estrone", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "phenindione", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "argatroban", "drug2": "estrone", "interaction_type": 12, "interaction_text": "argatroban may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "citric acid", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Dienogest", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Dienogest.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "estrone", "interaction_type": 12, "interaction_text": "Rivaroxaban may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "citric acid", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "phenindione", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "phenindione", "drug2": "estrone", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "EDTA", "drug2": "estriol", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "estriol", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Norelgestromin", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Norelgestromin.", "severity": 2}
{"drug1": "citric acid", "drug2": "estriol", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "warfarin", "drug2": "nafcillin", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of nafcillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "NORGESTIMATE", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of NORGESTIMATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "phenindione", "drug2": "cloxacillin", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of cloxacillin.", "severity": 2}
{"drug1": "EDTA", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Carbimazole", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Carbimazole.", "severity": 2}
{"drug1": "argatroban", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "argatroban may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Dienogest", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Dienogest.", "severity": 2}
{"drug1": "argatroban", "drug2": "estriol", "interaction_type": 12, "interaction_text": "argatroban may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "EDOXABAN may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "dicumarol", "drug2": "6-Mercaptopurine", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of 6-Mercaptopurine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Drospirenone", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Drospirenone.", "severity": 2}
{"drug1": "citric acid", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "warfarin", "drug2": "estriol", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "phenindione", "drug2": "Flucloxacillin", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Flucloxacillin.", "severity": 2}
{"drug1": "EDTA", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ETONOGESTREL", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of ETONOGESTREL.", "severity": 2}
{"drug1": "phenindione", "drug2": "DESOGESTREL", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of DESOGESTREL.", "severity": 2}
{"drug1": "warfarin", "drug2": "phytonadione", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of phytonadione.", "severity": 2}
{"drug1": "phenindione", "drug2": "potassium iodide", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of potassium iodide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "phenindione", "drug2": "Norelgestromin", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Norelgestromin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "estrone", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "warfarin", "drug2": "Levonorgestrel", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Levonorgestrel.", "severity": 2}
{"drug1": "warfarin", "drug2": "Sucralfate", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Sucralfate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "GESTODENE", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of GESTODENE.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "propylthiouracil", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of propylthiouracil.", "severity": 2}
{"drug1": "phenindione", "drug2": "dicloxacillin", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of dicloxacillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "dicloxacillin", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of dicloxacillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Sucralfate", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Sucralfate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cloxacillin", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of cloxacillin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Levonorgestrel", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Levonorgestrel.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Sucralfate", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Sucralfate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Drospirenone", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Drospirenone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "dicumarol", "drug2": "phytonadione", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of phytonadione.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "estriol", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "phenindione", "drug2": "phytonadione", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of phytonadione.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "methimazole", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of methimazole.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Flucloxacillin", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Flucloxacillin.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "estrone", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "warfarin", "drug2": "cloxacillin", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of cloxacillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "potassium iodide", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of potassium iodide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Norelgestromin", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Norelgestromin.", "severity": 2}
{"drug1": "warfarin", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "phenindione", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Carbimazole", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Carbimazole.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "estrone", "interaction_type": 12, "interaction_text": "Bivalirudin may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "phenindione", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "Dabigatran etexilate may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "Apixaban", "drug2": "estrone", "interaction_type": 12, "interaction_text": "Apixaban may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "dicloxacillin", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of dicloxacillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Coenzyme Q10", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Coenzyme Q10.", "severity": 2}
{"drug1": "EDTA", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "estriol", "interaction_type": 12, "interaction_text": "Rivaroxaban may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "Rivaroxaban may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cloxacillin", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of cloxacillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "norgestrel", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of norgestrel.", "severity": 2}
{"drug1": "phenindione", "drug2": "6-Mercaptopurine", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of 6-Mercaptopurine.", "severity": 2}
{"drug1": "phenindione", "drug2": "Dienogest", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Dienogest.", "severity": 2}
{"drug1": "phenindione", "drug2": "Estrone sulfate", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Estrone sulfate.", "severity": 2}
{"drug1": "warfarin", "drug2": "Carbimazole", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Carbimazole.", "severity": 2}
{"drug1": "phenindione", "drug2": "Coenzyme Q10", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Coenzyme Q10.", "severity": 2}
{"drug1": "warfarin", "drug2": "NORGESTIMATE", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of NORGESTIMATE.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "warfarin", "drug2": "azathioprine", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of azathioprine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "estrone", "interaction_type": 12, "interaction_text": "Ximelagatran may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "phenindione", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "citric acid", "drug2": "estrone", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "estrone", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Flucloxacillin", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Flucloxacillin.", "severity": 2}
{"drug1": "EDTA", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "phenindione", "drug2": "estramustine", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of estramustine.", "severity": 2}
{"drug1": "warfarin", "drug2": "DESOGESTREL", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of DESOGESTREL.", "severity": 2}
{"drug1": "warfarin", "drug2": "Drospirenone", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Drospirenone.", "severity": 2}
{"drug1": "citric acid", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Drospirenone", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Drospirenone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "propylthiouracil", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of propylthiouracil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "NORGESTIMATE", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of NORGESTIMATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "dicloxacillin", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of dicloxacillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "DESOGESTREL", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of DESOGESTREL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "estriol", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "estriol", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Flucloxacillin", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Flucloxacillin.", "severity": 2}
{"drug1": "phenindione", "drug2": "estriol", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "DESOGESTREL", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of DESOGESTREL.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "GESTODENE", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of GESTODENE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "6-Mercaptopurine", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of 6-Mercaptopurine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "propylthiouracil", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of propylthiouracil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "estrone", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "phenindione", "drug2": "azathioprine", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of azathioprine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "phenindione", "drug2": "ETONOGESTREL", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of ETONOGESTREL.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Flucloxacillin", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Flucloxacillin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "estramustine", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of estramustine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cloxacillin", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of cloxacillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Coenzyme Q10", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Coenzyme Q10.", "severity": 2}
{"drug1": "phenindione", "drug2": "Medroxyprogesterone acetate", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "norgestrel", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of norgestrel.", "severity": 2}
{"drug1": "Apixaban", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "Apixaban may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "Apixaban", "drug2": "estriol", "interaction_type": 12, "interaction_text": "Apixaban may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "phenindione", "drug2": "nafcillin", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of nafcillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "NORGESTIMATE", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of NORGESTIMATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "norgestrel", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of norgestrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "estriol", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Estrone sulfate", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Estrone sulfate.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "warfarin", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "citric acid", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "EDTA", "drug2": "estrone", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "Bivalirudin may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "azathioprine", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of azathioprine.", "severity": 2}
{"drug1": "warfarin", "drug2": "dicloxacillin", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of dicloxacillin.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "warfarin", "drug2": "propylthiouracil", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of propylthiouracil.", "severity": 2}
{"drug1": "warfarin", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "phenindione", "drug2": "GESTODENE", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of GESTODENE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ETONOGESTREL", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of ETONOGESTREL.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "phenindione", "drug2": "Sucralfate", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Sucralfate.", "severity": 2}
{"drug1": "phenindione", "drug2": "Levonorgestrel", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of Levonorgestrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ETONOGESTREL", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of ETONOGESTREL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "norgestrel", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of norgestrel.", "severity": 2}
{"drug1": "phenindione", "drug2": "methimazole", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of methimazole.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "estriol", "interaction_type": 12, "interaction_text": "EDOXABAN may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "warfarin", "drug2": "trazodone", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of trazodone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Estrone sulfate", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Estrone sulfate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "estriol", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "warfarin", "drug2": "methimazole", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of methimazole.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Dienogest", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of Dienogest.", "severity": 2}
{"drug1": "citric acid", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "citric acid may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "phenindione", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "phenindione may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "estriol", "interaction_type": 12, "interaction_text": "Ximelagatran may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "DESOGESTREL", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of DESOGESTREL.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "Ximelagatran may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "6-Mercaptopurine", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of 6-Mercaptopurine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "GESTODENE", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of GESTODENE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Norelgestromin", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Norelgestromin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "potassium iodide", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of potassium iodide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "estriol", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "azathioprine", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of azathioprine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "warfarin", "drug2": "GESTODENE", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of GESTODENE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Coenzyme Q10", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Coenzyme Q10.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "Fondaparinux may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Carbimazole", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Carbimazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "6-Mercaptopurine", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of 6-Mercaptopurine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "estramustine", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of estramustine.", "severity": 2}
{"drug1": "EDTA", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Levonorgestrel", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Levonorgestrel.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "methimazole", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of methimazole.", "severity": 2}
{"drug1": "dicumarol", "drug2": "estrone", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nafcillin", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of nafcillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "estramustine", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of estramustine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "estrone", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Medroxyprogesterone acetate", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "pentosan polysulfate may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Sucralfate", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Sucralfate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "estradiol", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of estradiol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Levonorgestrel", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Levonorgestrel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "PHENPROCOUMON may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "phytonadione", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of phytonadione.", "severity": 2}
{"drug1": "dicumarol", "drug2": "mestranol", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of mestranol.", "severity": 2}
{"drug1": "warfarin", "drug2": "ETONOGESTREL", "interaction_type": 12, "interaction_text": "warfarin may decrease the anticoagulant activities of ETONOGESTREL.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "dienestrol", "interaction_type": 12, "interaction_text": "3,4-Dihydroxybenzaldehyde may decrease the anticoagulant activities of dienestrol.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "estriol", "interaction_type": 12, "interaction_text": "Bivalirudin may decrease the anticoagulant activities of estriol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nafcillin", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of nafcillin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "QUINESTROL", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of QUINESTROL.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Estrone sulfate", "interaction_type": 12, "interaction_text": "dicumarol may decrease the anticoagulant activities of Estrone sulfate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Medroxyprogesterone acetate", "interaction_type": 12, "interaction_text": "ACENOCOUMAROL may decrease the anticoagulant activities of Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "EDTA", "drug2": "ethinyl estradiol", "interaction_type": 12, "interaction_text": "EDTA may decrease the anticoagulant activities of ethinyl estradiol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "estrone", "interaction_type": 12, "interaction_text": "EDOXABAN may decrease the anticoagulant activities of estrone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "diethylstilbestrol", "interaction_type": 12, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may decrease the anticoagulant activities of diethylstilbestrol.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with CICLOPIROX.", "severity": 2}
{"drug1": "Micafungin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Micafungin.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with tolnaftate.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Caspofungin.", "severity": 2}
{"drug1": "THYMOL", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with THYMOL.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Tavaborole.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Miltefosine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Isoconazole.", "severity": 2}
{"drug1": "sulconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with sulconazole.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "Artemether", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "haloprogin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with haloprogin.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with 5-Fluorocytosine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Anidulafungin.", "severity": 2}
{"drug1": "chloroxine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with chloroxine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with trimetrexate.", "severity": 2}
{"drug1": "miconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "fluconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with fluconazole.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with NATAMYCIN.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with amphotericin b.", "severity": 2}
{"drug1": "nystatin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with nystatin.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with EFINACONAZOLE.", "severity": 2}
{"drug1": "tioconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with tioconazole.", "severity": 2}
{"drug1": "terbinafine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with terconazole.", "severity": 2}
{"drug1": "itraconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with benzoic acid.", "severity": 2}
{"drug1": "bifonazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with bifonazole.", "severity": 2}
{"drug1": "rapamycin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Sertaconazole.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "cerulenin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with cerulenin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "hexetidine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with hexetidine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with clotrimazole.", "severity": 2}
{"drug1": "butenafine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with butenafine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Butoconazole.", "severity": 2}
{"drug1": "Naftifine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with Naftifine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with griseofulvin.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "progesterone", "interaction_type": 13, "interaction_text": "The absorption of progesterone can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "alprenolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "alprenolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "timolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "timolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "atenolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "atenolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "atenolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "timolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "timolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "timolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "timolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "timolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "atenolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "timolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "atenolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "timolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "timolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "atenolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "timolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "atenolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "atenolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "timolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "penbutolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "atenolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "timolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "timolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "timolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "alprenolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "atenolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "timolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "timolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "timolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "atenolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "timolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "timolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "atenolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "atenolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "formoterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of formoterol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "timolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "PROCATEROL", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of PROCATEROL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Arformoterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of Arformoterol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "clenbuterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of clenbuterol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Bambuterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of Bambuterol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "timolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Indacaterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of Indacaterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "isoetharine", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of isoetharine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Salmeterol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of Salmeterol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "isoproterenol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of isoproterenol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "timolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "timolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Vilanterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of Vilanterol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "atenolol may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "theophylline", "interaction_type": 14, "interaction_text": "celiprolol may decrease the bronchodilatory activities of theophylline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "terbutaline", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of terbutaline.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "aminophylline", "interaction_type": 14, "interaction_text": "BOPINDOLOL may decrease the bronchodilatory activities of aminophylline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Salbutamol", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of Salbutamol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "BISOPROLOL may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "OLODATEROL", "interaction_type": 14, "interaction_text": "oxprenolol may decrease the bronchodilatory activities of OLODATEROL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Levalbuterol", "interaction_type": 14, "interaction_text": "betaxolol may decrease the bronchodilatory activities of Levalbuterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "metaproterenol", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of metaproterenol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "phenylpropanolamine", "interaction_type": 14, "interaction_text": "penbutolol may decrease the bronchodilatory activities of phenylpropanolamine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "dyphylline", "interaction_type": 14, "interaction_text": "alprenolol may decrease the bronchodilatory activities of dyphylline.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "PIRBUTEROL", "interaction_type": 14, "interaction_text": "BUPRANOLOL may decrease the bronchodilatory activities of PIRBUTEROL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ritodrine", "interaction_type": 14, "interaction_text": "acebutolol may decrease the bronchodilatory activities of ritodrine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "ESMOLOL may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "celiprolol", "interaction_type": 14, "interaction_text": "metoprolol may decrease the bronchodilatory activities of celiprolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "dobutamine", "interaction_type": 14, "interaction_text": "Nebivolol may decrease the bronchodilatory activities of dobutamine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ARBUTAMINE", "interaction_type": 14, "interaction_text": "CARTEOLOL may decrease the bronchodilatory activities of ARBUTAMINE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Romidepsin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Romidepsin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Iobenguane", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Iobenguane.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "tibolone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of tibolone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "pipobroman", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of pipobroman.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "5-Fluorouracil", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of 5-Fluorouracil.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Idelalisib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Idelalisib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "gemcitabine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of gemcitabine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "teniposide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of teniposide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Epirubicin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Epirubicin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "topotecan", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of topotecan.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "dexamethasone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of dexamethasone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "6-Mercaptopurine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of 6-Mercaptopurine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "IMIQUIMOD", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of IMIQUIMOD.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Alitretinoin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Alitretinoin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "anastrozole", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of anastrozole.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Amrubicin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Amrubicin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "5-Aminolevulinic acid", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of 5-Aminolevulinic acid.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "oxaliplatin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of oxaliplatin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Clofarabine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Clofarabine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Venetoclax", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Venetoclax.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "prednisone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of prednisone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "bicalutamide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of bicalutamide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "methyltestosterone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of methyltestosterone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Imatinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Imatinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "docetaxel", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of docetaxel.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "melphalan", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of melphalan.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "hydroxyurea", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of hydroxyurea.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of HYDROXYPROGESTERONE CAPROATE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "letrozole", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of letrozole.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "mitomycin C", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of mitomycin C.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Bexarotene", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Bexarotene.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "toremifene", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of toremifene.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "vindesine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of vindesine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "ciprofloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of ciprofloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "busulfan", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of busulfan.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Erlotinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Erlotinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Decitabine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Decitabine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "trimetrexate", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of trimetrexate.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Trifluridine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Trifluridine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Gemifloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Gemifloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Dexrazoxane", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Dexrazoxane.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Valrubicin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Valrubicin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "5-azacytidine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of 5-azacytidine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "flutamide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of flutamide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "dacarbazine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of dacarbazine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Pixantrone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Pixantrone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Niraparib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Niraparib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Vismodegib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Vismodegib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Vandetanib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Vandetanib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Gefitinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Gefitinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Nilotinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Nilotinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Miltefosine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Miltefosine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "diethylstilbestrol", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of diethylstilbestrol.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "azelaic acid", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of azelaic acid.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "goserelin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of goserelin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "vincristine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of vincristine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Dasatinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Dasatinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "homoharringtonine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of homoharringtonine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "osimertinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of osimertinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "fleroxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of fleroxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Vorinostat", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Vorinostat.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "streptozocin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of streptozocin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Sorafenib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Sorafenib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "RUCAPARIB", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of RUCAPARIB.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Pefloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Pefloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Lenalidomide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Lenalidomide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "testolactone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of testolactone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "MEDROGESTONE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of MEDROGESTONE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Vinflunine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Vinflunine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "carboplatin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of carboplatin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Dienogest", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Dienogest.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "altretamine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of altretamine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "methylprednisolone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of methylprednisolone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Regorafenib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Regorafenib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Pralatrexate", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Pralatrexate.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "plicamycin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of plicamycin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "vinorelbine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of vinorelbine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of 4-PHENYLBUTYRIC ACID.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Ibrutinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Ibrutinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "podophyllotoxin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of podophyllotoxin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "methotrexate", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of methotrexate.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Cladribine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Cladribine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Pirlindole", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Pirlindole.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "IDARUBICIN", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of IDARUBICIN.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "amsacrine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of amsacrine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "cabergoline", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of cabergoline.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Sunitinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Sunitinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Pemetrexed", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Pemetrexed.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "mebendazole", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of mebendazole.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Uramustine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Uramustine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "cinoxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of cinoxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Pazopanib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Pazopanib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Fulvestrant", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Fulvestrant.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "mechlorethamine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of mechlorethamine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Olaparib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Olaparib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Axitinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Axitinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Nelarabine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Nelarabine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "resveratrol", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of resveratrol.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "TEMOPORFIN", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of TEMOPORFIN.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "thiotepa", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of thiotepa.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Trabectedin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Trabectedin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "procarbazine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of procarbazine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "arsenic trioxide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of arsenic trioxide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "tegafur", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of tegafur.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Ixabepilone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Ixabepilone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "tamoxifen", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of tamoxifen.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "ofloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of ofloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "irinotecan", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of irinotecan.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Fludarabine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Fludarabine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Masoprocol", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Masoprocol.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "rapamycin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of rapamycin.", "severity": 4}
{"drug1": "pentostatin", "drug2": "cyclophosphamide", "interaction_type": 15, "interaction_text": "pentostatin may increase the cardiotoxic activities of cyclophosphamide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Midostaurin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Midostaurin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Ruxolitinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Ruxolitinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Cabozantinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Cabozantinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Erismodegib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Erismodegib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Eribulin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Eribulin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Bortezomib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Bortezomib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "PHENYLACETIC ACID", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of PHENYLACETIC ACID.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "carmustine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of carmustine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "anagrelide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of anagrelide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "estramustine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of estramustine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "vinblastine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of vinblastine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Carfilzomib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Carfilzomib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "nilutamide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of nilutamide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "thalidomide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of thalidomide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "lomustine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of lomustine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "moxifloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of moxifloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Gatifloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Gatifloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Octreotide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Octreotide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "LYCOPENE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of LYCOPENE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Calcipotriol", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Calcipotriol.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "nalidixic acid", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of nalidixic acid.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "CYPROTERONE ACETATE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of CYPROTERONE ACETATE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "sparfloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of sparfloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Bendamustine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Bendamustine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "PONATINIB", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of PONATINIB.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "tretinoin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of tretinoin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "formestane", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of formestane.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Crizotinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Crizotinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "TRIPTORELIN", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of TRIPTORELIN.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Vapreotide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Vapreotide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "thioguanine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of thioguanine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "MEGESTROL ACETATE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of MEGESTROL ACETATE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "cytarabine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of cytarabine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "aminoglutethimide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of aminoglutethimide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "etoposide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of etoposide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "daunorubicin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of daunorubicin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Lenvatinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Lenvatinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Nintedanib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Nintedanib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "norfloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of norfloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "VERTEPORFIN", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of VERTEPORFIN.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Degarelix", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Degarelix.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "enoxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of enoxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Raltitrexed", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Raltitrexed.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "chlorambucil", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of chlorambucil.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "bleomycin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of bleomycin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Trilostane", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Trilostane.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "lomefloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of lomefloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "suramin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of suramin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Lapatinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Lapatinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Nedaplatin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Nedaplatin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Bosutinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Bosutinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "CAPECITABINE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of CAPECITABINE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "actinomycin D", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of actinomycin D.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "quinacrine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of quinacrine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Pomalidomide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Pomalidomide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Trametinib", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Trametinib.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "temozolomide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of temozolomide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Radium-223 chloride", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Radium-223 chloride.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "CABAZITAXEL", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of CABAZITAXEL.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Besifloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Besifloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Gallium nitrate", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Gallium nitrate.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Ecabet", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Ecabet.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "EXEMESTANE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of EXEMESTANE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Temsirolimus", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Temsirolimus.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Methyl aminolevulinate", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Methyl aminolevulinate.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "4-Methoxyphenol", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of 4-Methoxyphenol.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "doxorubicin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of doxorubicin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "ifosfamide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of ifosfamide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Trovafloxacin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Trovafloxacin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "retinol", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of retinol.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "floxuridine", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of floxuridine.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "PIRFENIDONE", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of PIRFENIDONE.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Belinostat", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Belinostat.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "mycophenolate mofetil", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of mycophenolate mofetil.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "mycophenolic acid", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of mycophenolic acid.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "cisplatin", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of cisplatin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "PAMIDRONIC ACID", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of PAMIDRONIC ACID.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Lanreotide", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Lanreotide.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "sulindac", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of sulindac.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "mitoxantrone", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of mitoxantrone.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "albendazole", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of albendazole.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "LEVOFLOXACIN", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "Medroxyprogesterone acetate", "interaction_type": 15, "interaction_text": "cyclophosphamide may increase the cardiotoxic activities of Medroxyprogesterone acetate.", "severity": 4}
{"drug1": "reserpine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "butorphanol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "proparacaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "methadone", "drug2": "flumazenil", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of flumazenil.", "severity": 3}
{"drug1": "zolpidem", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "meprobamate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "azelastine", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "azelastine", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "phenytoin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "estazolam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "primidone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "butorphanol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "butorphanol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "methadone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "ethanol", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "ethanol", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "thiamylal", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "trazodone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "trazodone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "butamben", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "clemastine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "clonidine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "methadone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "buspirone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "Halazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "desipramine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "clorazepate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "clonidine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "alprazolam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "trimipramine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Tapentadol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "amisulpride", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "lorazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "tetracaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "isoflurane", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "halothane", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "levorphanol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Etomidate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "estazolam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "morphine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "efavirenz", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "prilocaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "felbamate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "efavirenz", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "azelastine", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "codeine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "azelastine", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "Retigabine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "meperidine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "propofol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "alprazolam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "cocaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "clidinium", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "Nabilone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Melatonin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "Melatonin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "cetirizine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "doxepin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "tetracaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "clonidine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "flurazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "enflurane", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zotepine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zotepine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "butorphanol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "doxylamine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "proparacaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Halazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "promethazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "ketamine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "ethanol", "drug2": "primidone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "protriptyline", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "azelastine", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "butamben", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "pimozide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HEROIN", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "doxylamine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "butalbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "azelastine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "brotizolam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "ethanol", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "ethanol", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "isoflurane", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "procaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "Normethadone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "hydroxyzine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "imipramine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "doxepin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "clonazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "triazolam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "triazolam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "Perospirone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "azelastine", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "cocaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "methadone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "scopolamine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Asenapine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "lithium ion", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "triprolidine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "zonisamide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "maprotiline", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "methadone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "methadone", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "topiramate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "triazolam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "Retigabine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "protriptyline", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "amisulpride", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "promazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "clomipramine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "dyclonine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "thalidomide", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "gabapentin", "drug2": "Magnesium salicylate", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of Magnesium salicylate.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "oxycodone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "temazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "butorphanol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "zolpidem", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "desipramine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "estazolam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "azelastine", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "clemastine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "amoxapine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "tizanidine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "MAGNESIUM SULFATE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "scopolamine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "clemastine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "olanzapine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "diazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "promazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "doxepin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "zolpidem", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "ethanol", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "ethanol", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "perphenazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "meperidine", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "butamben", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "alprazolam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "propofol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "dibucaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "levorphanol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "perphenazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Tramadol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "prilocaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "triazolam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "alprazolam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "trazodone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "codeine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "Melatonin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "perphenazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "butalbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "thalidomide", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "dibucaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "cocaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "triprolidine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "zolpidem", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of zolpidem.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "flurazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "MAGNESIUM SULFATE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "butamben", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "diazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "orphenadrine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of orphenadrine.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "imipramine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "triprolidine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "tiagabine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "azelastine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "dyclonine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "loratadine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "meperidine", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "zaleplon", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "Halazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Halazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "clorazepate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "azelastine", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "thiothixene", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "triprolidine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "mirtazapine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of mirtazapine.", "severity": 3}
{"drug1": "promazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "enflurane", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "enflurane", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Asenapine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "ethotoin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "tiapride", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "tiapride", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "benzocaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "phenytoin", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "doxepin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "protriptyline", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "reserpine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "protriptyline", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "propofol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "azelastine", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "Tramadol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "topiramate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "Articaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "quetiapine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "methadone", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "Butethal", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "prilocaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "butalbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "clomipramine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "quazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "primidone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "azelastine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "ethanol", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "zonisamide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "azelastine", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "propofol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "gabapentin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "oxazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "butamben", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "estazolam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "promethazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "etizolam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "pimozide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "topiramate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "triprolidine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "azelastine", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "amisulpride", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "amisulpride", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "promazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "secobarbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "scopolamine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "trimipramine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "ethanol", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "primidone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "glutethimide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "bromazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "protriptyline", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "amobarbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "triazolam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "methadone", "drug2": "Delorazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Delorazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "halothane", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "dibucaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "procaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "zolpidem", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "amoxapine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "clemastine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Etomidate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "zolpidem", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "primidone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "tiagabine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "codeine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "clonazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "hydroxyzine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "butamben", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "Tapentadol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ondansetron", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "quetiapine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "primidone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "quetiapine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "Butethal", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thiamylal", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "thiamylal", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "ethanol", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "orphenadrine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of orphenadrine.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "promethazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "azelastine", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "zaleplon", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "levorphanol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zaleplon", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "ethanol", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "ethanol", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Tramadol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "codeine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "risperidone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "prazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "haloperidol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "promazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "promazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "clorazepate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "butalbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "risperidone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "baclofen", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "alprazolam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Etomidate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "meprobamate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ondansetron", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "enflurane", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zotepine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "butamben", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "loratadine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "promazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "levorphanol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "methadone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "halothane", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Articaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zaleplon", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "ethanol", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "secobarbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "trimipramine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "lorazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "primidone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "azelastine", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "flunarizine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "topiramate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "prilocaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "secobarbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "butamben", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "meperidine", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "pentazocine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "promazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "oxazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "imipramine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thiamylal", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "efavirenz", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Asenapine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "azelastine", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "morphine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "perphenazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "Perospirone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "azelastine", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "loxapine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "proparacaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "proparacaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "codeine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "butabarbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "levodopa", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "pimozide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "tiapride", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "thalidomide", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "ethanol", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "cetirizine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "cetirizine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "methadone", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "prazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thioridazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "felbamate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "etizolam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "prilocaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "desipramine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "haloperidol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "clonidine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "lidocaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "procaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "maprotiline", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "Perospirone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zonisamide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "zolpidem", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of zolpidem.", "severity": 3}
{"drug1": "butabarbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "topiramate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "efavirenz", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "cocaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "ethanol", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "clozapine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "butorphanol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Asenapine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "flunarizine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "haloperidol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zopiclone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "clidinium", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "dantrolene", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "maprotiline", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "Normethadone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "droperidol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "droperidol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "ethanol", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "codeine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "tetracaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "clemastine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "clemastine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "amisulpride", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "felbamate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "enflurane", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "butorphanol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "quetiapine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "morphine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "codeine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "lidocaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "promethazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "quazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "oxycodone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Retigabine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "zolpidem", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "thiopental", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "azelastine", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "flunarizine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "thiamylal", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "primidone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "oxycodone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "dantrolene", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "oxybutynin", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "oxybutynin may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "meclizine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "proparacaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "tiagabine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "imipramine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HEROIN", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "ethanol", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "ethanol", "drug2": "promazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "propofol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "ethanol", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "clonidine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "desipramine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "meperidine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "alprazolam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "doxepin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "meperidine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "risperidone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "PARALDEHYDE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of PARALDEHYDE.", "severity": 3}
{"drug1": "clonazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "meperidine", "drug2": "primidone", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "cocaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "haloperidol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "phenytoin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "azelastine", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "thalidomide", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "trazodone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zotepine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "promethazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "azelastine", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "meperidine", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "Normethadone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "Normethadone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Melatonin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "pimozide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "lorazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "isoflurane", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "promethazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "azelastine", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "flunarizine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "estazolam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zaleplon", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "azelastine", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "clorazepate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "lidocaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "lidocaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "perphenazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thiopental", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "ethanol", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "Camazepam", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Camazepam.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "ethanol", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "ethotoin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thiothixene", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "oxazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "clidinium", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "meprobamate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "azelastine", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "azelastine", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "pimozide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "azelastine", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "morphine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "loxapine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "proparacaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "clonazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "ethanol", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "ethanol", "drug2": "morphine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "Etomidate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "ethanol", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Perospirone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "zotepine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "Delorazepam", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Delorazepam.", "severity": 3}
{"drug1": "azelastine", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "quazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zonisamide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "clozapine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "oxazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "quazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "trazodone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "tiagabine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "procaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thiothixene", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "procaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "doxepin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "temazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "ethotoin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "zolpidem", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "thalidomide", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HEROIN", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "trazodone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zotepine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "Tapentadol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Tapentadol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "clonidine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "tetracaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "levodopa", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "azelastine", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "azelastine", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "sulpiride", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "tizanidine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "triazolam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "pimozide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "clonazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "hydroxyzine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "midazolam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "ethanol", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "mirtazapine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of mirtazapine.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Retigabine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "amoxapine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "azelastine", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "Nabilone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "quetiapine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "pentazocine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "prazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "olanzapine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "gabapentin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "tetracaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "maprotiline", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "halothane", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "cetirizine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "azelastine", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "azelastine", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "azelastine", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "temazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "meperidine", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "maprotiline", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "amoxapine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "mirtazapine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of mirtazapine.", "severity": 3}
{"drug1": "diazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Nabilone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "levodopa", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ondansetron", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethotoin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "MAGNESIUM SULFATE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "azelastine", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "amantadine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "amantadine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "promazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "flurazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "procaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "loratadine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "alprazolam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Normethadone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "butabarbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "triazolam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "glutethimide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "tiapride", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "pentazocine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "loratadine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "dantrolene", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "clidinium", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "tizanidine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "oxycodone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "thalidomide", "drug2": "propofol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "ethanol", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "codeine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "quazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "triprolidine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "secobarbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "quetiapine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Perospirone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "tiapride", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "ethanol", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "methadone", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "thioridazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "tiagabine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "glutethimide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "baclofen", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "methadone", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "ethotoin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "zolpidem", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "midazolam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "etizolam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "morphine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "sulpiride", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "cocaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "flunarizine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "etizolam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "etizolam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "temazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "azelastine", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "midazolam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "meclizine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "promazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "protriptyline", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "ethanol", "drug2": "halothane", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "ketamine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "ketamine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "methadone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "butalbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "lidocaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "butalbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "bromazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Retigabine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "buspirone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "felbamate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thiopental", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thiopental", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "methadone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "meclizine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "risperidone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "flurazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "Nabilone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "thalidomide", "drug2": "halothane", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zolpidem", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "loxapine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "desipramine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "morphine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "amoxapine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "pimozide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "tiapride", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "oxycodone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "azelastine", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "azelastine", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "azelastine", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "ethanol", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "efavirenz", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "meclizine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "sulpiride", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "risperidone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "azelastine", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "desipramine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "brimonidine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "Butethal", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "dibucaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "brotizolam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "efavirenz", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "quetiapine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "buprenorphine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of buprenorphine.", "severity": 3}
{"drug1": "brotizolam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ondansetron", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ondansetron", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "scopolamine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "haloperidol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "bromazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "Etomidate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "isoflurane", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "procaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "loxapine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "levorphanol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "promazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "propofol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "Articaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "alprazolam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "Tramadol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "butamben", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "benzocaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "zotepine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "butorphanol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "ethanol", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "azelastine", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "morphine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "promethazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "pentazocine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "pentazocine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zonisamide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "triprolidine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "triprolidine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "ethanol", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "baclofen", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "baclofen", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Perospirone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "prilocaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "tetracaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "clozapine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "doxylamine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "olanzapine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "butabarbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Suvorexant", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "proparacaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Melatonin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "zonisamide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "ethanol", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "primidone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "prilocaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ketamine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "desipramine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "thioridazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "thioridazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "haloperidol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zopiclone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "dantrolene", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "loratadine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "promazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "oxazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "pentazocine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "tizanidine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "tizanidine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "pimozide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "thalidomide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "meperidine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zonisamide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "efavirenz", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "clomipramine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "ketamine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "lorazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "lorazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "HEROIN", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thiothixene", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "zolpidem", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "dantrolene", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "dantrolene", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "codeine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "felbamate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "felbamate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "zotepine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Asenapine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "doxylamine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "desipramine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "primidone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "ethanol", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "thalidomide", "drug2": "STIRIPENTOL", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of STIRIPENTOL.", "severity": 3}
{"drug1": "propofol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "cocaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "dibucaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "triazolam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "butamben", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "zolpidem", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "meprobamate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "propofol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Melatonin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "ethanol", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "etizolam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "Asenapine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Asenapine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "mianserin", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of mianserin.", "severity": 3}
{"drug1": "azelastine", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "baclofen", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "Retigabine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "cetirizine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Retigabine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "codeine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "clonazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "lorazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "reserpine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "oxycodone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "buspirone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "procaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "azelastine", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "clonidine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "enflurane", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "thiopental", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "oxazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "brimonidine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "ethanol", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "flunarizine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "imipramine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "enflurane", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "propofol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "bromazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "pimozide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Articaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "ethanol", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "azelastine", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "azelastine", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "azelastine", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "methadone", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "methadone", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "mirtazapine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of mirtazapine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "dibucaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "promazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "olanzapine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "benzocaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "procaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "alprazolam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "quazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "dyclonine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "dyclonine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "clozapine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zolpidem", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "ethanol", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "tizanidine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Halazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "butabarbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "meperidine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "clidinium", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "gabapentin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "clomipramine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "baclofen", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "dyclonine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "clidinium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "MAGNESIUM SULFATE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "MAGNESIUM SULFATE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "dyclonine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "trazodone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "amobarbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "amobarbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "Tapentadol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "zaleplon", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "phenytoin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "clidinium", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "maprotiline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "imipramine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "isoflurane", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "loxapine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "morphine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "prilocaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "prilocaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "methadone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "primidone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "procaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "methadone", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "reserpine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "thalidomide", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "morphine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "STIRIPENTOL", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of STIRIPENTOL.", "severity": 3}
{"drug1": "morphine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "flurazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thiothixene", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "ethanol", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "azelastine", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "methadone", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "propofol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "pimozide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "tetracaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "olanzapine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "reserpine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "thiothixene", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "glutethimide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "zopiclone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "amisulpride", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "methadone", "drug2": "pirenzepine", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of pirenzepine.", "severity": 3}
{"drug1": "procaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Butethal", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "felbamate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ketamine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "estazolam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "Melatonin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "butabarbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "dibucaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "loxapine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "methadone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "ketamine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "amisulpride", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "efavirenz", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "primidone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Asenapine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ketamine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "estazolam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "buspirone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "meperidine", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "Perospirone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "procaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "diazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "protriptyline", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "azelastine", "drug2": "procaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "flunarizine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "olanzapine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "lorazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Butethal", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "morphine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "thiamylal", "drug2": "mianserin", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of mianserin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "methadone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "meclizine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "trimipramine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "lidocaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "clonazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "levorphanol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "clonazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "clonidine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "azelastine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "perphenazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "gabapentin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM HYDROXIDE.", "severity": 3}
{"drug1": "topiramate", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "olanzapine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "olanzapine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "meperidine", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "azelastine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "amoxapine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "felbamate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Tramadol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thioridazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "secobarbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "butamben", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "secobarbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "meprobamate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "benzocaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "glutethimide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "prazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "zolpidem", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thiamylal", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "flurazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "levodopa", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "propofol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "temazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "loratadine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "clidinium", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "Normethadone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "secobarbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "gabapentin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM OXIDE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "prilocaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "meprobamate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "levorphanol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "butalbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "oxazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "reserpine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "butalbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "levorphanol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "cetirizine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "tizanidine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "primidone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "zaleplon", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "ethanol", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "sulpiride", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "sulpiride", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "reserpine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "gabapentin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "lorazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "dyclonine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "procaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "doxepin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "butamben", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "tiagabine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "butamben", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "midazolam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "thalidomide", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "levodopa", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "clomipramine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "MAGNESIUM SULFATE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "Tramadol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thioridazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "methadone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "halothane", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "codeine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "gabapentin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "methadone", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "scopolamine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "zonisamide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "protriptyline", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "azelastine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "azelastine", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "thiopental", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "etizolam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "topiramate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "azelastine", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "doxylamine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "ketamine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "zolpidem", "drug2": "morphine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "oxycodone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thiamylal", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "lidocaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "hydroxyzine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "ethanol", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "ethanol", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "thalidomide", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "zonisamide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "clozapine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "methadone", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "risperidone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "thalidomide", "drug2": "promazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "thalidomide", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "promazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "ethotoin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "primidone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "brotizolam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "brotizolam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "butamben", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "ethanol", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "halothane", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "butabarbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "azelastine", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "brotizolam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "risperidone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "thalidomide", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "thalidomide", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "Nabilone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "methadone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "estazolam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "estazolam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "clemastine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "butorphanol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "ethanol", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "buspirone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "tiapride", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Butethal", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thiamylal", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "flunarizine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thiopental", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "levodopa", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "lidocaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "clonazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "meclizine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "buspirone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "azelastine", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "brimonidine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "zolpidem", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "cetirizine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "meperidine", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "thalidomide", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "halothane", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "ethanol", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Etomidate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "gabapentin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "azelastine", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "azelastine", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "alprazolam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "Fesoterodine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Fesoterodine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "meclizine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "meclizine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "azelastine", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "morphine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "meperidine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "oxycodone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "tiapride", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Halazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "doxylamine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "zopiclone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "morphine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "doxepin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "prazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "meperidine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "azelastine", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "brotizolam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "temazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "loxapine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "diazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "baclofen", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "loxapine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "sulpiride", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "prazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "maprotiline", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "diazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "sulpiride", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "phenytoin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "clonazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "thiopental", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "levodopa", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "temazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "flurazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "levorphanol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Etomidate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "flurazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "Halazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "butamben", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "mianserin", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of mianserin.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "codeine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "amobarbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "quazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thioridazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "propofol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "propofol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "propofol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "methadone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "morphine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "gabapentin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "topiramate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "cetirizine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "amobarbital", "drug2": "mianserin", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of mianserin.", "severity": 3}
{"drug1": "lorazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Perospirone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "amoxapine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HEROIN", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "HEROIN", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "propofol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "trazodone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "scopolamine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "ethanol", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "brotizolam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "buprenorphine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of buprenorphine.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "methadone", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "scopolamine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HEROIN", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "buprenorphine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of buprenorphine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "methadone", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "ethanol", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "thalidomide", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "imipramine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "Articaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "cocaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "zolpidem", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "flunarizine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "clomipramine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "Etomidate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "clonazepam", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "butamben", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Articaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "diazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "meperidine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "clozapine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "azelastine", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "imipramine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "Tramadol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "loratadine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Butethal", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "methadone", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "Oxetacaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Oxetacaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zotepine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "thalidomide", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "cetirizine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "dyclonine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thalidomide", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "thalidomide", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "Articaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Melatonin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "Trospium", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Trospium may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "meclizine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "bromazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "butamben", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "diazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "azelastine", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "butamben", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "dibucaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "doxylamine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "azelastine", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "levodopa", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Oxybuprocaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "oxycodone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zaleplon", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "trimipramine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "methadone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "morphine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "triazolam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zonisamide", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "proparacaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "ethanol", "drug2": "procaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "Tramadol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "tizanidine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ondansetron", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "morphine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "amobarbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "benzocaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "doxepin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "ethanol", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "etizolam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "haloperidol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "phenytoin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "amobarbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "lidocaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "prilocaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "prilocaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "thalidomide", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "lidocaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "secobarbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "diazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "primidone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Dexbrompheniramine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "phenytoin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ondansetron", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "temazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Etomidate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "dantrolene", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "azelastine", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "pentazocine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "scopolamine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "clorazepate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "butabarbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "butabarbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "triazolam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "meprobamate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "levodopa", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "clomipramine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "MAGNESIUM SULFATE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "MAGNESIUM SULFATE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "ethanol", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "mirtazapine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of mirtazapine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "codeine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "halothane", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "codeine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "quazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "pimozide", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "pimozide may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "butabarbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "dyclonine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ketamine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "topiramate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "clomipramine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "promethazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "codeine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "secobarbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "ethanol", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "procaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "procaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "reserpine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "meclizine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "clemastine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Melatonin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "clozapine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "pentazocine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Lormetazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "midazolam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "felbamate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "perphenazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "olanzapine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "flurazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "thiothixene", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "flunarizine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "flunarizine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "flunarizine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "quetiapine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "ethanol", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "Tapentadol", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Tapentadol may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "azelastine", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "azelastine", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "zolpidem", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "MELPERONE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of MELPERONE.", "severity": 3}
{"drug1": "azelastine", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "thalidomide", "drug2": "procaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of procaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "azelastine", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "azelastine", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "butamben", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "halothane", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "tetracaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "prazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "azelastine", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "loratadine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "halothane", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HEROIN", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Pramocaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Pramocaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "meprobamate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "clemastine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "pentazocine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of pentazocine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "azelastine", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "diazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "primidone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "trimethobenzamide", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "midazolam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Halazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "promazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "methadone", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "primidone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "brimonidine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "tizanidine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "propofol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "zolpidem", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "Perospirone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "procaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "glutethimide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "efavirenz", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "olanzapine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Butethal", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "Normethadone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "cetirizine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thiothixene", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "enflurane", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "ethanol", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "ethanol", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "butalbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethotoin", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Melatonin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "buspirone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "halothane", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "dibucaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "doxylamine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "benzocaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "tiagabine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Mephobarbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Mephobarbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "tiagabine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "codeine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "dantrolene", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "trimipramine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "prilocaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of prilocaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "SUFENTANIL", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "SUFENTANIL may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "ethanol", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "Methadyl acetate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Methadyl acetate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thiothixene", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Tramadol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "tiagabine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "brotizolam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of brotizolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "benzocaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "PARALDEHYDE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of PARALDEHYDE.", "severity": 3}
{"drug1": "risperidone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "STIRIPENTOL", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of STIRIPENTOL.", "severity": 3}
{"drug1": "ethanol", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "secobarbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "lidocaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "lidocaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "baclofen", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "prazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "oxazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "tetracaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "brimonidine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "trimipramine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "azelastine", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "meprobamate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "clemastine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "methadone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "Tramadol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "trazodone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Tramadol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Tramadol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "azelastine", "drug2": "methadone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "midazolam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "flunarizine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of flunarizine.", "severity": 3}
{"drug1": "loxapine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "clonidine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "ethanol", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "haloperidol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "promazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Halazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethanol", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "ethotoin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethotoin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "risperidone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "risperidone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "risperidone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "amisulpride", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "tiapride", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "carbamazepine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "lorazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "secobarbital", "drug2": "mianserin", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of mianserin.", "severity": 3}
{"drug1": "ethanol", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "dantrolene", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "doxylamine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "brimonidine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "ethanol", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "pirenzepine", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of pirenzepine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "meprobamate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "glutethimide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thioridazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "ethanol", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "ethanol", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "azelastine", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "brotizolam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "phenytoin", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "ethanol", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "chlormezanone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "chlormezanone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "procaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "propofol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "lithium ion", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "tiagabine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "amobarbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "protriptyline", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "ethanol", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "doxylamine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "doxylamine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "oxycodone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Nabilone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "sulpiride", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "ethanol", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "brimonidine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "tiapride", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "azelastine", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "azelastine", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "loxapine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "clozapine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "lorazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "lorazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "Levocetirizine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "bromazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "dantrolene", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "ethanol", "drug2": "clidinium", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of clidinium.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "dyclonine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Perospirone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buspirone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buspirone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "FLUPHENAZINE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "FLUPHENAZINE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "benzocaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "isoflurane", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HEROIN", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "isoflurane", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "bromazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Asenapine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "butamben", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "proparacaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "azelastine", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "glutethimide", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "ethanol", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "oxazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ondansetron", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Ramelteon", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Ramelteon may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Olopatadine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "azelastine", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "ethanol", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "trimipramine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "butorphanol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "ethanol", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "topiramate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "benzyl alcohol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "ethanol", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "azelastine", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "midazolam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zopiclone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "methadone", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "baclofen", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "droperidol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "droperidol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "gabapentin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "felbamate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "efavirenz", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "hydroxyzine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "amoxapine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "procaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "perphenazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "REMIFENTANIL", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of REMIFENTANIL.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "triazolam", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of triazolam.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "tiagabine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "tiagabine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "perphenazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "oxazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "zotepine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "morphine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "morphine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "morphine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "benzocaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "meperidine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Butethal", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thiopental", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "quazepam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "clorazepate", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Desloratadine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "nitrous oxide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "orphenadrine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of orphenadrine.", "severity": 3}
{"drug1": "brimonidine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Normethadone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "STIRIPENTOL", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of STIRIPENTOL.", "severity": 3}
{"drug1": "clorazepate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "haloperidol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "tiapride", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of tiapride.", "severity": 3}
{"drug1": "clonazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "clonazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "methadone", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "amisulpride", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of amisulpride.", "severity": 3}
{"drug1": "azelastine", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "amobarbital", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "scopolamine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "perphenazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "cetirizine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "cetirizine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thioridazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "sulpiride", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "quetiapine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "benzocaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "hydroxyzine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "zolpidem", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of zolpidem.", "severity": 3}
{"drug1": "pentazocine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "glutethimide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "promazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "ethanol", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "bromazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of bromazepam.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Butethal", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Levobupivacaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.", "severity": 3}
{"drug1": "cyclobenzaprine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "VALPROIC ACID may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethanol", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "clemastine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of clemastine.", "severity": 3}
{"drug1": "Articaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "clozapine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "azelastine", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "clidinium", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zaleplon", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zopiclone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Sodium oxybate", "drug2": "flumazenil", "interaction_type": 16, "interaction_text": "Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of flumazenil.", "severity": 3}
{"drug1": "prazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "oxprenolol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "oxprenolol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "haloperidol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "methadone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "ketamine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ketamine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "promazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "halothane", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "mirtazapine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of mirtazapine.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "thiopental", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "orphenadrine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of orphenadrine.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "benzocaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of benzocaine.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "SERTINDOLE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "SERTINDOLE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of TRICHLOROETHYLENE.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Etomidate", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "trifluoperazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "levorphanol", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of levorphanol.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "perphenazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of perphenazine.", "severity": 3}
{"drug1": "maprotiline", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "HEROIN", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "methocarbamol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of methocarbamol.", "severity": 3}
{"drug1": "ethanol", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "proparacaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "PARALDEHYDE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of PARALDEHYDE.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "chlordiazepoxide", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ondansetron", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "clomipramine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of clomipramine.", "severity": 3}
{"drug1": "methadone", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "reserpine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of reserpine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "promethazine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "vigabatrin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "vigabatrin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "azelastine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HEROIN", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "HEROIN may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "quazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "tetracaine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "dibucaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "REMIFENTANIL", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "REMIFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "clozapine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "gabapentin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "zonisamide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "zonisamide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "zopiclone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "protriptyline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Fluspirilene", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "azelastine", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "Ziprasidone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "Perampanel", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Perampanel may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "maprotiline", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "mesoridazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "mesoridazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Asenapine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Asenapine.", "severity": 3}
{"drug1": "thiothixene", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "propofol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "quazepam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "quazepam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "ethanol", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "ethanol", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "nalbuphine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "nalbuphine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "orphenadrine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of orphenadrine.", "severity": 3}
{"drug1": "scopolamine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "azelastine", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "morphine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "proparacaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of proparacaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "VORTIOXETINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of VORTIOXETINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "DIPHENOXYLATE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of DIPHENOXYLATE.", "severity": 3}
{"drug1": "bromazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "halothane", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "proparacaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "proparacaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "dantrolene", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of dantrolene.", "severity": 3}
{"drug1": "Flibanserin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Flibanserin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "estazolam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of estazolam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "codeine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "STIRIPENTOL", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of STIRIPENTOL.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "secobarbital", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "secobarbital may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "clemastine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "clemastine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "PARALDEHYDE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of PARALDEHYDE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "PARALDEHYDE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of PARALDEHYDE.", "severity": 3}
{"drug1": "ethanol", "drug2": "butamben", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of butamben.", "severity": 3}
{"drug1": "azelastine", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "phenytoin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Fosphenytoin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "perphenazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "perphenazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "primidone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "zaleplon", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Suvorexant", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.", "severity": 3}
{"drug1": "thalidomide", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "VORTIOXETINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "VORTIOXETINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "amobarbital", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Propoxycaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Pramocaine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.", "severity": 3}
{"drug1": "azelastine", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "imipramine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "halothane", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "temazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Tramadol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "azelastine", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "baclofen", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "nitrous oxide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of nitrous oxide.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "clonidine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "clonidine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "butalbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "butalbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "butalbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "quetiapine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of quetiapine.", "severity": 3}
{"drug1": "estazolam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Levomepromazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Levomepromazine.", "severity": 3}
{"drug1": "Asenapine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "zolpidem", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "ethyl loflazepate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "codeine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "azelastine", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "clorazepate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of clorazepate.", "severity": 3}
{"drug1": "azelastine", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "efavirenz", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of efavirenz.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "lidocaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of lidocaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "methadone", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Tapentadol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Tapentadol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Articaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "Articaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "buspirone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "amisulpride", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "chloral hydrate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of chloral hydrate.", "severity": 3}
{"drug1": "trazodone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "morphine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of morphine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "clozapine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "clozapine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "ethanol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of 4-Hydroxybutanoic acid.", "severity": 3}
{"drug1": "ethanol", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "isoflurane", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Tasimelteon", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "desipramine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "desipramine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Aripiprazole", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thiothixene", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "thiothixene may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "FLUPHENAZINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "mianserin", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of mianserin.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "thalidomide", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of thalidomide.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Etomidate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Etomidate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Zuclopenthixol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Nabilone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "STIRIPENTOL", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "STIRIPENTOL may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "METAXALONE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "METAXALONE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "DESFLURANE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of DESFLURANE.", "severity": 3}
{"drug1": "Lurasidone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Lurasidone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "DIMENHYDRINATE", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "DIMENHYDRINATE may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "DEXMEDETOMIDINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "DEXMEDETOMIDINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ethotoin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ethotoin.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "diphenhydramine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "reserpine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "CYCLIZINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "CYCLIZINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "tetracaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "tetracaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "gabapentin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of gabapentin.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "triprolidine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "bromazepam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Melatonin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Melatonin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "clorazepate", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "phenytoin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "triflupromazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of triflupromazine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "pentazocine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "4-Hydroxybutanoic acid may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "olanzapine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "olanzapine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "halothane", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "azelastine", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "fludiazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of fludiazepam.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "doxepin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "KETAZOLAM", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "KETAZOLAM may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethotoin", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "ethanol", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "clorazepate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "clorazepate", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "azelastine", "drug2": "codeine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "azelastine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of azelastine.", "severity": 3}
{"drug1": "azelastine", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "azelastine", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "triprolidine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "clidinium", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "bromazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "procaine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "procaine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "prazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of prazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "topiramate", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of topiramate.", "severity": 3}
{"drug1": "flurazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "oxprenolol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of oxprenolol.", "severity": 3}
{"drug1": "clomipramine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Flupentixol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.", "severity": 3}
{"drug1": "clomipramine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Fencamfamin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "meprobamate", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "meprobamate may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "tizanidine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of tizanidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "CYPROHEPTADINE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of CYPROHEPTADINE.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "maprotiline", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "fludiazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "fludiazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "prochlorperazine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of prochlorperazine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Articaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Articaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "tetracaine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of tetracaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "pimozide", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of pimozide.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "isoflurane", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of isoflurane.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "Butethal", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Butethal may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "trimipramine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "tizanidine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "phenytoin", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "phenytoin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "azelastine", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "azelastine", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "doxepin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "doxepin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "primidone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "BREXPIPRAZOLE", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "BREXPIPRAZOLE may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "oxymorphone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "oxymorphone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "triflupromazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "triflupromazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "tranylcypromine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of tranylcypromine.", "severity": 3}
{"drug1": "amisulpride", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "oxycodone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "oxycodone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "levodopa", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "levodopa may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "lithium ion may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "Normethadone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "zolpidem", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "DIPHENOXYLATE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "DIPHENOXYLATE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "phenobarbital", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of phenobarbital.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Levocetirizine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Pregabalin", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "temazepam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of temazepam.", "severity": 3}
{"drug1": "MAGNESIUM SULFATE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "MAGNESIUM SULFATE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "mepivacaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of mepivacaine.", "severity": 3}
{"drug1": "zopiclone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "zopiclone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "MOLINDONE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of MOLINDONE.", "severity": 3}
{"drug1": "glutethimide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "butabarbital", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of butabarbital.", "severity": 3}
{"drug1": "loratadine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "felbamate", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "felbamate may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "codeine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "zopiclone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of zopiclone.", "severity": 3}
{"drug1": "methadone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "loxapine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "loxapine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "clonazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of clonazepam.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "oxymorphone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of oxymorphone.", "severity": 3}
{"drug1": "thioridazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "bupivacaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Perospirone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Perospirone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "clomipramine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "clomipramine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "DIMENHYDRINATE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of DIMENHYDRINATE.", "severity": 3}
{"drug1": "thalidomide", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "cocaine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of cocaine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Retigabine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Retigabine.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "thalidomide", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Desloratadine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "chlorpheniramine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "loratadine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "estazolam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "estazolam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "maprotiline", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "maprotiline may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "sulpiride", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Fospropofol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "tizanidine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "tizanidine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "ethanol", "drug2": "ketamine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of ketamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "codeine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of codeine.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "trazodone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of trazodone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Ketobemidone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.", "severity": 3}
{"drug1": "carisoprodol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "pentobarbital", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of pentobarbital.", "severity": 3}
{"drug1": "ethanol", "drug2": "VALPROIC ACID", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of VALPROIC ACID.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "diazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "diazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "methocarbamol", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "ethanol", "drug2": "benzyl alcohol", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of benzyl alcohol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "promethazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of promethazine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "doxepin", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of doxepin.", "severity": 3}
{"drug1": "azelastine", "drug2": "halothane", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Lurasidone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.", "severity": 3}
{"drug1": "azelastine", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "nortriptyline", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "nortriptyline may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "midazolam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "GUANFACINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of GUANFACINE.", "severity": 3}
{"drug1": "Iloperidone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Iloperidone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Iloperidone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "clozapine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of clozapine.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "thalidomide", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "brimonidine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "propofol", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of propofol.", "severity": 3}
{"drug1": "temazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Flupentixol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Flupentixol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "carbamazepine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of carbamazepine.", "severity": 3}
{"drug1": "fluvoxamine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "GUANFACINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "GUANFACINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Pizotifen", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "Retigabine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "thiothixene", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of thiothixene.", "severity": 3}
{"drug1": "promazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "promazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "BREXPIPRAZOLE", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "STIRIPENTOL", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of STIRIPENTOL.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of FLUTICASONE PROPIONATE.", "severity": 3}
{"drug1": "bromazepam", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "bromazepam may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "zotepine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of zotepine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "primidone", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of primidone.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Normethadone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "PARALDEHYDE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of PARALDEHYDE.", "severity": 3}
{"drug1": "Levetiracetam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "Retigabine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Eszopiclone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "phenytoin", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of phenytoin.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "HEROIN", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of HEROIN.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Gabapentin enacarbil", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Gabapentin enacarbil.", "severity": 3}
{"drug1": "alprazolam", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "alprazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "butorphanol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of butorphanol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Butethal", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Butethal.", "severity": 3}
{"drug1": "primidone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "primidone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "primidone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "meperidine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "loratadine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of loratadine.", "severity": 3}
{"drug1": "azelastine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "imipramine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of imipramine.", "severity": 3}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "FLUTICASONE PROPIONATE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "METHSUXIMIDE", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "METHSUXIMIDE may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "dyclonine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "dyclonine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "brotizolam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "amoxapine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "SUFENTANIL", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of SUFENTANIL.", "severity": 3}
{"drug1": "gabapentin", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Ketobemidone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Ketobemidone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "ondansetron", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "lorazepam", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of lorazepam.", "severity": 3}
{"drug1": "pentobarbital", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "glutethimide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "glutethimide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Difenoxin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Difenoxin may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "baclofen", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of baclofen.", "severity": 3}
{"drug1": "Remoxipride", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Remoxipride may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "butorphanol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "butorphanol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "ethchlorvynol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of ethchlorvynol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "azelastine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "desipramine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "desipramine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "buprenorphine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of buprenorphine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "dyclonine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of dyclonine.", "severity": 3}
{"drug1": "ethanol", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "Normethadone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Normethadone may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "glutethimide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of glutethimide.", "severity": 3}
{"drug1": "trazodone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "trazodone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "enflurane", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "halothane", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "halothane", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "amitriptyline", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of amitriptyline.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "azelastine", "drug2": "CYCLIZINE", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of CYCLIZINE.", "severity": 3}
{"drug1": "ethchlorvynol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "etizolam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "amoxapine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "haloperidol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of haloperidol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Ethylmorphine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.", "severity": 3}
{"drug1": "quetiapine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "dantrolene", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "dantrolene may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "amoxapine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of amoxapine.", "severity": 3}
{"drug1": "amoxapine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "amoxapine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levobupivacaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Levobupivacaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "nortriptyline", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of nortriptyline.", "severity": 3}
{"drug1": "flurazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "flurazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Levetiracetam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Etomidate", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Ropivacaine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Pipamperone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.", "severity": 3}
{"drug1": "ALFENTANIL", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "ALFENTANIL may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "thiamylal", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "Tasimelteon", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.", "severity": 3}
{"drug1": "loratadine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "loratadine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "flurazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of flurazepam.", "severity": 3}
{"drug1": "efavirenz", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "efavirenz may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "zotepine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "zotepine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "TRICHLOROETHYLENE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "cocaine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "clonidine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of clonidine.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "quetiapine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "quetiapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "zonisamide", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of zonisamide.", "severity": 3}
{"drug1": "thioridazine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "thioridazine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "meperidine", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "chloral hydrate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "amobarbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "nitrazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of nitrazepam.", "severity": 3}
{"drug1": "zopiclone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mepivacaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "amisulpride", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "amisulpride may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "propoxyphene", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "propoxyphene may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Gabapentin enacarbil", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "chlordiazepoxide", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of chlordiazepoxide.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "ethosuximide", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "meprobamate", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of meprobamate.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "halothane", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "halothane may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Pomalidomide", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "trimipramine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "Asenapine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Asenapine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "trimipramine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "trimipramine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "azelastine", "drug2": "Etidocaine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Halazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Halazepam.", "severity": 3}
{"drug1": "chlorprothixene", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Pomalidomide", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.", "severity": 3}
{"drug1": "meclizine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "meclizine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Pipamperone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Pipamperone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "amobarbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of amobarbital.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Hexobarbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.", "severity": 3}
{"drug1": "ondansetron", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "ondansetron may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "dibucaine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "dibucaine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "sevoflurane", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "sevoflurane may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Halazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "Retigabine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "levorphanol", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Retigabine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Retigabine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "promethazine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "benzocaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "benzocaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "isoflurane", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "MELPERONE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "MELPERONE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Dexbrompheniramine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Hexobarbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Pizotifen", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Pizotifen may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "azelastine", "drug2": "ethyl loflazepate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of ethyl loflazepate.", "severity": 3}
{"drug1": "azelastine", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "Melatonin", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Melatonin may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "thalidomide", "drug2": "olanzapine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of olanzapine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "methadone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of methadone.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Ramelteon", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.", "severity": 3}
{"drug1": "TETRABENAZINE", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "TETRABENAZINE may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "prazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "prazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "prazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "clorazepate", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "clorazepate may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "temazepam", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "temazepam may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "baclofen", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "baclofen may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Pregabalin", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "clidinium", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "clidinium may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "oxazepam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "oxazepam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "buspirone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "buspirone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "carisoprodol", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of carisoprodol.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "flunitrazepam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "ethotoin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "ethotoin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "flunitrazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of flunitrazepam.", "severity": 3}
{"drug1": "Fosphenytoin", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Lormetazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Agomelatine", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.", "severity": 3}
{"drug1": "butabarbital", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "butabarbital may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Tolcapone", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Tolcapone may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "ethanol", "drug2": "thioridazine", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of thioridazine.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "propofol", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Pipotiazine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "bupivacaine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of bupivacaine.", "severity": 3}
{"drug1": "DIHYDROCODEINE", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "DIHYDROCODEINE may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "midazolam", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "pentazocine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "pentazocine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Articaine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Articaine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "amobarbital", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "amobarbital may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Ropivacaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "zolpidem", "drug2": "secobarbital", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of secobarbital.", "severity": 3}
{"drug1": "thalidomide", "drug2": "chlormezanone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of chlormezanone.", "severity": 3}
{"drug1": "etizolam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "CHLOROPROCAINE", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "CHLOROPROCAINE may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "ethanol", "drug2": "KETAZOLAM", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of KETAZOLAM.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "mirtazapine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of mirtazapine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "oxazepam", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of oxazepam.", "severity": 3}
{"drug1": "meperidine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "nalbuphine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of nalbuphine.", "severity": 3}
{"drug1": "codeine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "codeine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Mephobarbital", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Mephobarbital.", "severity": 3}
{"drug1": "zolpidem", "drug2": "trimipramine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of trimipramine.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "TETRABENAZINE", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of TETRABENAZINE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "chlorzoxazone", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of chlorzoxazone.", "severity": 3}
{"drug1": "Nabilone", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Nabilone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zolpidem", "drug2": "ALFENTANIL", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of ALFENTANIL.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "triprolidine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of triprolidine.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "zolpidem", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of zolpidem.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Eszopiclone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "alprazolam", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of alprazolam.", "severity": 3}
{"drug1": "reserpine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "reserpine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "promazine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of promazine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Remoxipride", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "loxapine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of loxapine.", "severity": 3}
{"drug1": "thiopental", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "thiopental may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "prochlorperazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "ethosuximide", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of ethosuximide.", "severity": 3}
{"drug1": "OXCARBAZEPINE", "drug2": "ethanol", "interaction_type": 16, "interaction_text": "OXCARBAZEPINE may increase the central nervous system depressant (CNS depressant) activities of ethanol.", "severity": 3}
{"drug1": "levorphanol", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "levorphanol may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "chlorpheniramine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of chlorpheniramine.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "cyclobenzaprine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of cyclobenzaprine.", "severity": 3}
{"drug1": "azelastine", "drug2": "Fencamfamin", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of Fencamfamin.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "methoxyflurane", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "Oxetacaine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.", "severity": 3}
{"drug1": "CYPROHEPTADINE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "CYPROHEPTADINE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "etizolam", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "etizolam may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Difenoxin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.", "severity": 3}
{"drug1": "thalidomide", "drug2": "thiopental", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of thiopental.", "severity": 3}
{"drug1": "midazolam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "midazolam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "hydromorphone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "MOLINDONE", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "MOLINDONE may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "brotizolam", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "brotizolam may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "sulpiride", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of sulpiride.", "severity": 3}
{"drug1": "azelastine", "drug2": "trifluoperazine", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of trifluoperazine.", "severity": 3}
{"drug1": "DESFLURANE", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "DESFLURANE may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "zolpidem", "drug2": "Methadyl acetate", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of Methadyl acetate.", "severity": 3}
{"drug1": "enflurane", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "zolpidem", "drug2": "dibucaine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of dibucaine.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Agomelatine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "Agomelatine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "METHSUXIMIDE", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of METHSUXIMIDE.", "severity": 3}
{"drug1": "thiamylal", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "cocaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "triprolidine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "triprolidine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "ondansetron", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of ondansetron.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "tiagabine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of tiagabine.", "severity": 3}
{"drug1": "amitriptyline", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "amitriptyline may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "thalidomide", "drug2": "Paliperidone", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.", "severity": 3}
{"drug1": "topiramate", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "Halazepam", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Halazepam may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "haloperidol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "haloperidol may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "butalbital", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of butalbital.", "severity": 3}
{"drug1": "imipramine", "drug2": "brimonidine", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of brimonidine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Ziprasidone", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.", "severity": 3}
{"drug1": "imipramine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "imipramine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "zolpidem", "drug2": "scopolamine", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of scopolamine.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "Zuclopenthixol", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.", "severity": 3}
{"drug1": "butamben", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "butamben may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "meclizine", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of meclizine.", "severity": 3}
{"drug1": "Perospirone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Perospirone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "lithium ion", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of lithium ion.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "risperidone", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of risperidone.", "severity": 3}
{"drug1": "meperidine", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "meperidine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "enflurane", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of enflurane.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "tiapride", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "tiapride may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "zolpidem", "drug2": "METHOHEXITAL", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of METHOHEXITAL.", "severity": 3}
{"drug1": "fexofenadine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "fexofenadine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Olopatadine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "sulpiride", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "sulpiride may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "thiamylal", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "thiamylal may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "quazepam", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of quazepam.", "severity": 3}
{"drug1": "ethanol", "drug2": "CHLOROPROCAINE", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of CHLOROPROCAINE.", "severity": 3}
{"drug1": "methadone", "drug2": "midazolam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of midazolam.", "severity": 3}
{"drug1": "METHOHEXITAL", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "METHOHEXITAL may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "methadone", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "gabapentin", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "gabapentin may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "azelastine", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "fexofenadine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of fexofenadine.", "severity": 3}
{"drug1": "azelastine", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "zopiclone", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "zopiclone may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "mesoridazine", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of mesoridazine.", "severity": 3}
{"drug1": "azelastine", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "thalidomide", "drug2": "maprotiline", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of maprotiline.", "severity": 3}
{"drug1": "orphenadrine", "drug2": "Flibanserin", "interaction_type": 16, "interaction_text": "orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.", "severity": 3}
{"drug1": "zolpidem", "drug2": "DEXMEDETOMIDINE", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of DEXMEDETOMIDINE.", "severity": 3}
{"drug1": "zolpidem", "drug2": "methoxyflurane", "interaction_type": 16, "interaction_text": "zolpidem may increase the central nervous system depressant (CNS depressant) activities of methoxyflurane.", "severity": 3}
{"drug1": "brimonidine", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "brimonidine may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "Perampanel", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "DEZOCINE", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "DEZOCINE may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "nitrazepam may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "zaleplon", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "zaleplon may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "propofol", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "propofol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "ethanol", "drug2": "vigabatrin", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of vigabatrin.", "severity": 3}
{"drug1": "protriptyline", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "protriptyline may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "fluvoxamine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of fluvoxamine.", "severity": 3}
{"drug1": "ethanol", "drug2": "sevoflurane", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of sevoflurane.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "propoxyphene", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of propoxyphene.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "METAXALONE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of METAXALONE.", "severity": 3}
{"drug1": "ethanol", "drug2": "Tolcapone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.", "severity": 3}
{"drug1": "cocaine", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "cocaine may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "promethazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "promethazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "ethanol", "drug2": "hydromorphone", "interaction_type": 16, "interaction_text": "ethanol may increase the central nervous system depressant (CNS depressant) activities of hydromorphone.", "severity": 3}
{"drug1": "Fluspirilene", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "isoflurane", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "buprenorphine", "drug2": "Normethadone", "interaction_type": 16, "interaction_text": "buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Normethadone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "thiamylal", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of thiamylal.", "severity": 3}
{"drug1": "enflurane", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "enflurane may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "PARALDEHYDE", "drug2": "SERTINDOLE", "interaction_type": 16, "interaction_text": "PARALDEHYDE may increase the central nervous system depressant (CNS depressant) activities of SERTINDOLE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "desipramine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of desipramine.", "severity": 3}
{"drug1": "azelastine", "drug2": "oxycodone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of oxycodone.", "severity": 3}
{"drug1": "scopolamine", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "scopolamine may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "thalidomide", "drug2": "zaleplon", "interaction_type": 16, "interaction_text": "thalidomide may increase the central nervous system depressant (CNS depressant) activities of zaleplon.", "severity": 3}
{"drug1": "Aceprometazine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "azelastine", "drug2": "buspirone", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of buspirone.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "halothane", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of halothane.", "severity": 3}
{"drug1": "Paliperidone", "drug2": "Dronabinol", "interaction_type": 16, "interaction_text": "Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "diphenhydramine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of diphenhydramine.", "severity": 3}
{"drug1": "isoflurane", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "isoflurane may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "Propoxycaine", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "Propoxycaine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "Ethylmorphine", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "Ethylmorphine may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "azelastine", "drug2": "felbamate", "interaction_type": 16, "interaction_text": "azelastine may increase the central nervous system depressant (CNS depressant) activities of felbamate.", "severity": 3}
{"drug1": "Pipotiazine", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "Fospropofol", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Fospropofol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "Oxybuprocaine", "drug2": "Perampanel", "interaction_type": 16, "interaction_text": "Oxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.", "severity": 3}
{"drug1": "methadone", "drug2": "Nabilone", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Nabilone.", "severity": 3}
{"drug1": "HYDROCODONE", "drug2": "Aceprometazine", "interaction_type": 16, "interaction_text": "HYDROCODONE may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.", "severity": 3}
{"drug1": "chlorzoxazone", "drug2": "Tapentadol", "interaction_type": 16, "interaction_text": "chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.", "severity": 3}
{"drug1": "methadone", "drug2": "etizolam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of etizolam.", "severity": 3}
{"drug1": "Suvorexant", "drug2": "DEZOCINE", "interaction_type": 16, "interaction_text": "Suvorexant may increase the central nervous system depressant (CNS depressant) activities of DEZOCINE.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "diazepam", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of diazepam.", "severity": 3}
{"drug1": "topiramate", "drug2": "droperidol", "interaction_type": 16, "interaction_text": "topiramate may increase the central nervous system depressant (CNS depressant) activities of droperidol.", "severity": 3}
{"drug1": "methadone", "drug2": "Camazepam", "interaction_type": 16, "interaction_text": "methadone may increase the central nervous system depressant (CNS depressant) activities of Camazepam.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "DIHYDROCODEINE", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of DIHYDROCODEINE.", "severity": 3}
{"drug1": "triazolam", "drug2": "doxylamine", "interaction_type": 16, "interaction_text": "triazolam may increase the central nervous system depressant (CNS depressant) activities of doxylamine.", "severity": 3}
{"drug1": "Perampanel", "drug2": "minocycline", "interaction_type": 16, "interaction_text": "Perampanel may increase the central nervous system depressant (CNS depressant) activities of minocycline.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "chlorprothixene", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of chlorprothixene.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "Aripiprazole", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.", "severity": 3}
{"drug1": "Levomepromazine", "drug2": "hydroxyzine", "interaction_type": 16, "interaction_text": "Levomepromazine may increase the central nervous system depressant (CNS depressant) activities of hydroxyzine.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "Sodium oxybate", "interaction_type": 16, "interaction_text": "phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "protriptyline", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of protriptyline.", "severity": 3}
{"drug1": "Etidocaine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 16, "interaction_text": "Etidocaine may increase the central nervous system depressant (CNS depressant) activities of MAGNESIUM SULFATE.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "levodopa", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of levodopa.", "severity": 3}
{"drug1": "mirtazapine", "drug2": "cetirizine", "interaction_type": 16, "interaction_text": "mirtazapine may increase the central nervous system depressant (CNS depressant) activities of cetirizine.", "severity": 3}
{"drug1": "ETHACRYNIC ACID", "drug2": "Rocuronium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of Rocuronium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "decamethonium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of decamethonium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Doxacurium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of Doxacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Atracurium besylate", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of Atracurium besylate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "mefloquine may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "succinylcholine", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of succinylcholine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "galanthamine may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "decamethonium may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "furosemide", "drug2": "succinylcholine", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of succinylcholine.", "severity": 2}
{"drug1": "furosemide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "furosemide", "drug2": "pancuronium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of pancuronium.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "rivastigmine may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "donepezil", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "donepezil may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Doxacurium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of Doxacurium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "decamethonium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of decamethonium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "pancuronium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of pancuronium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "METOCURINE", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of METOCURINE.", "severity": 2}
{"drug1": "furosemide", "drug2": "PIPECURONIUM", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of PIPECURONIUM.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "phenytoin may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "tubocurarine", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of tubocurarine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Atracurium besylate", "interaction_type": 17, "interaction_text": "Fosphenytoin may decrease the neuromuscular blocking activities of Atracurium besylate.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "succinylcholine", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of succinylcholine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Rocuronium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of Rocuronium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Rocuronium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of Rocuronium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "PYRANTEL", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of PYRANTEL.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "ambenonium may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "GALLAMINE TRIETHIODIDE may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "Echothiophate may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "physostigmine may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "malathion", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "malathion may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Vecuronium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of Vecuronium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "pancuronium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of pancuronium.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "edrophonium may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "pyridostigmine may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Atracurium besylate", "interaction_type": 17, "interaction_text": "phenytoin may decrease the neuromuscular blocking activities of Atracurium besylate.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Rocuronium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of Rocuronium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Vecuronium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of Vecuronium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Atracurium besylate", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of Atracurium besylate.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tubocurarine", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of tubocurarine.", "severity": 2}
{"drug1": "furosemide", "drug2": "PYRANTEL", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of PYRANTEL.", "severity": 2}
{"drug1": "furosemide", "drug2": "decamethonium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of decamethonium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "PYRANTEL", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of PYRANTEL.", "severity": 2}
{"drug1": "bumetanide", "drug2": "PIPECURONIUM", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of PIPECURONIUM.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "PIPECURONIUM", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of PIPECURONIUM.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Vecuronium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of Vecuronium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "NEOSTIGMINE may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "pancuronium", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of pancuronium.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "tubocurarine may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "METOCURINE", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of METOCURINE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "metoclopramide may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "PYRANTEL", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of PYRANTEL.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "PIPECURONIUM", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of PIPECURONIUM.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Atracurium besylate", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of Atracurium besylate.", "severity": 2}
{"drug1": "Torasemide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Cisatracurium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of Cisatracurium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Atracurium besylate", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of Atracurium besylate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "Fosphenytoin may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Doxacurium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of Doxacurium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "METOCURINE", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of METOCURINE.", "severity": 2}
{"drug1": "memantine", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "memantine may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "succinylcholine", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of succinylcholine.", "severity": 2}
{"drug1": "furosemide", "drug2": "METOCURINE", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of METOCURINE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "tubocurarine", "interaction_type": 17, "interaction_text": "ETHACRYNIC ACID may decrease the neuromuscular blocking activities of tubocurarine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Doxacurium", "interaction_type": 17, "interaction_text": "Torasemide may decrease the neuromuscular blocking activities of Doxacurium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "decamethonium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of decamethonium.", "severity": 2}
{"drug1": "furosemide", "drug2": "tubocurarine", "interaction_type": 17, "interaction_text": "furosemide may decrease the neuromuscular blocking activities of tubocurarine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Vecuronium", "interaction_type": 17, "interaction_text": "bumetanide may decrease the neuromuscular blocking activities of Vecuronium.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "Isoflurophate may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Mivacurium", "interaction_type": 17, "interaction_text": "Demecarium may decrease the neuromuscular blocking activities of Mivacurium.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "SODIUM BICARBONATE can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "famotidine", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "famotidine can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "doxepin", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "doxepin can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "ROXATIDINE ACETATE can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "dextroamphetamine", "interaction_type": 18, "interaction_text": "lansoprazole can cause an increase in the absorption of dextroamphetamine resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "promethazine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "promethazine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "ranitidine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "dextroamphetamine", "interaction_type": 18, "interaction_text": "dexlansoprazole can cause an increase in the absorption of dextroamphetamine resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Trometamol can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ethanol", "drug2": "tacrolimus", "interaction_type": 18, "interaction_text": "ethanol can cause an increase in the absorption of tacrolimus resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "olanzapine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "CALCIUM CARBONATE can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Trometamol", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Trometamol can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "SODIUM BICARBONATE can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "dextroamphetamine", "interaction_type": 18, "interaction_text": "Esomeprazole can cause an increase in the absorption of dextroamphetamine resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "promethazine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "promethazine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "omeprazole", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "omeprazole can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "epinastine", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "epinastine can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Magaldrate can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "Aluminium hydroxide", "interaction_type": 18, "interaction_text": "l-ascorbic acid can cause an increase in the absorption of Aluminium hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "AMPHETAMINE", "interaction_type": 18, "interaction_text": "dexlansoprazole can cause an increase in the absorption of AMPHETAMINE resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "olanzapine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "famotidine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "famotidine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "lansoprazole can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "CALCIUM CARBONATE can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "rabeprazole can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "famotidine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "famotidine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Almasilate", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Almasilate can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Aluminium hydroxide can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "dextroamphetamine", "interaction_type": 18, "interaction_text": "pantoprazole can cause an increase in the absorption of dextroamphetamine resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "rabeprazole can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "Asenapine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Potassium citrate", "drug2": "Aluminium hydroxide", "interaction_type": 18, "interaction_text": "Potassium citrate can cause an increase in the absorption of Aluminium hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "nizatidine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ranitidine", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "ranitidine can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "omeprazole", "drug2": "AMPHETAMINE", "interaction_type": 18, "interaction_text": "omeprazole can cause an increase in the absorption of AMPHETAMINE resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "lansoprazole can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "cimetidine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "omeprazole can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "AMPHETAMINE", "interaction_type": 18, "interaction_text": "lansoprazole can cause an increase in the absorption of AMPHETAMINE resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "AMPHETAMINE", "interaction_type": 18, "interaction_text": "pantoprazole can cause an increase in the absorption of AMPHETAMINE resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Asenapine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "pantoprazole can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Magnesium trisilicate can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "AMPHETAMINE", "interaction_type": 18, "interaction_text": "Esomeprazole can cause an increase in the absorption of AMPHETAMINE resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "ROXATIDINE ACETATE can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "cimetidine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "pantoprazole can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "AMPHETAMINE", "interaction_type": 18, "interaction_text": "rabeprazole can cause an increase in the absorption of AMPHETAMINE resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Bismuth subcitrate potassium can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Magaldrate can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "dexlansoprazole can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Aluminium hydroxide can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "dexlansoprazole can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Sodium citrate", "drug2": "Aluminium hydroxide", "interaction_type": 18, "interaction_text": "Sodium citrate can cause an increase in the absorption of Aluminium hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "MAGNESIUM OXIDE can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "ranitidine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "dextroamphetamine", "interaction_type": 18, "interaction_text": "rabeprazole can cause an increase in the absorption of dextroamphetamine resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "nizatidine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "MAGNESIUM OXIDE can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Esomeprazole can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Bismuth subcitrate potassium can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "epinastine", "drug2": "Risedronic acid", "interaction_type": 18, "interaction_text": "epinastine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "cimetidine", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "cimetidine can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "MAGNESIUM HYDROXIDE can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "MAGNESIUM HYDROXIDE can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Magnesium trisilicate can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Almasilate can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ethanol", "drug2": "Levomilnacipran", "interaction_type": 18, "interaction_text": "ethanol can cause an increase in the absorption of Levomilnacipran resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ethanol", "drug2": "Treprostinil", "interaction_type": 18, "interaction_text": "ethanol can cause an increase in the absorption of Treprostinil resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "promethazine", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "promethazine can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "Aluminium can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "cyclosporin A", "interaction_type": 18, "interaction_text": "metoclopramide can cause an increase in the absorption of cyclosporin A resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Esomeprazole can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "omeprazole", "drug2": "dextroamphetamine", "interaction_type": 18, "interaction_text": "omeprazole can cause an increase in the absorption of dextroamphetamine resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "epinastine", "drug2": "Dexmethylphenidate", "interaction_type": 18, "interaction_text": "epinastine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "ROXATIDINE ACETATE can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "Aluminium", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "Aluminium can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "nizatidine", "drug2": "methylphenidate", "interaction_type": 18, "interaction_text": "nizatidine can cause an increase in the absorption of methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.", "severity": 2}
{"drug1": "cabergoline", "drug2": "acebutolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of acebutolol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ERGOTAMINE", "interaction_type": 19, "interaction_text": "LISURIDE may increase the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Metipranolol", "interaction_type": 19, "interaction_text": "dihydroergotamine may increase the vasoconstricting activities of Metipranolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "LEVOBUNOLOL", "interaction_type": 19, "interaction_text": "dihydroergotamine may increase the vasoconstricting activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "atenolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of atenolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "sotalol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of sotalol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sotalol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of sotalol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "propranolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of propranolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "celiprolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of celiprolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "ropinirole may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "dihydroergotamine", "interaction_type": 19, "interaction_text": "apomorphine may increase the vasoconstricting activities of dihydroergotamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "LEVOBUNOLOL", "interaction_type": 19, "interaction_text": "bromocriptine may increase the vasoconstricting activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Metipranolol", "interaction_type": 19, "interaction_text": "bromocriptine may increase the vasoconstricting activities of Metipranolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nadolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of nadolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "CARTEOLOL", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of CARTEOLOL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "atenolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of atenolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "BUPRANOLOL", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of BUPRANOLOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Metipranolol", "interaction_type": 19, "interaction_text": "ERGOTAMINE may increase the vasoconstricting activities of Metipranolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "LEVOBUNOLOL", "interaction_type": 19, "interaction_text": "ERGOTAMINE may increase the vasoconstricting activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "ERGOTAMINE", "interaction_type": 19, "interaction_text": "pergolide may increase the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "BOPINDOLOL", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of BOPINDOLOL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "alprenolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of alprenolol.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "rizatriptan may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "cabergoline", "interaction_type": 19, "interaction_text": "ropinirole may increase the vasoconstricting activities of cabergoline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "acebutolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of acebutolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "LEVOBUNOLOL", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Nebivolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of Nebivolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Arotinolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of Arotinolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "penbutolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of penbutolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "practolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of practolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Bevantolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of Bevantolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ESMOLOL", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of ESMOLOL.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "VORTIOXETINE may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "bromocriptine", "interaction_type": 19, "interaction_text": "LISURIDE may increase the vasoconstricting activities of bromocriptine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "cabergoline", "interaction_type": 19, "interaction_text": "apomorphine may increase the vasoconstricting activities of cabergoline.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "Vilazodone may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "pergolide", "drug2": "bromocriptine", "interaction_type": 19, "interaction_text": "pergolide may increase the vasoconstricting activities of bromocriptine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "CARTEOLOL", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of CARTEOLOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "metoprolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of metoprolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "carvedilol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of carvedilol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "betaxolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of betaxolol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "cabergoline", "interaction_type": 19, "interaction_text": "LISURIDE may increase the vasoconstricting activities of cabergoline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "propranolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of propranolol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "Frovatriptan may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "pergolide", "drug2": "cabergoline", "interaction_type": 19, "interaction_text": "pergolide may increase the vasoconstricting activities of cabergoline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "timolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of timolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "oxprenolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of oxprenolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "alprenolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of alprenolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Arotinolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of Arotinolol.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "sumatriptan may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "zolmitriptan may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Metipranolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of Metipranolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "carvedilol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of carvedilol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Metipranolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of Metipranolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "BOPINDOLOL", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of BOPINDOLOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "LEVOBUNOLOL", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "BUPRANOLOL", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of BUPRANOLOL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "timolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of timolol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "Almotriptan may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "practolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of practolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Bevantolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of Bevantolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Nebivolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of Nebivolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "penbutolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of penbutolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "apomorphine may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "labetalol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of labetalol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "betaxolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of betaxolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nadolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of nadolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "labetalol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of labetalol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "metoprolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of metoprolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "oxprenolol", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of oxprenolol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "Eletriptan may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "BISOPROLOL", "interaction_type": 19, "interaction_text": "methylergonovine may increase the vasoconstricting activities of BISOPROLOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "BISOPROLOL", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of BISOPROLOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ESMOLOL", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of ESMOLOL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ERGOTAMINE", "interaction_type": 19, "interaction_text": "apomorphine may increase the vasoconstricting activities of ERGOTAMINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "celiprolol", "interaction_type": 19, "interaction_text": "cabergoline may increase the vasoconstricting activities of celiprolol.", "severity": 2}
{"drug1": "naratriptan", "drug2": "methylergonovine", "interaction_type": 19, "interaction_text": "naratriptan may increase the vasoconstricting activities of methylergonovine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "methadone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "domperidone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Asenapine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "Asenapine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Lurasidone", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Lurasidone.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Artemether", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "amiodarone", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Quinine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "cisapride", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Artemether", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Artemether", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "granisetron", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "clozapine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "granisetron", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "pentamidine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "granisetron", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "thioridazine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "disopyramide", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "promazine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Telavancin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "toremifene", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "arsenic trioxide", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of arsenic trioxide.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "amiodarone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "cisapride", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "cisapride", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "disopyramide", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "methadone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "propafenone", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "propafenone", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Asenapine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "granisetron", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "propafenone", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "granisetron", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "sotalol", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "Telavancin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Quinine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "citalopram", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "quinidine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "sotalol", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "flecainide", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "flecainide", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "sotalol", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "pimozide", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "sotalol", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Quinine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "sotalol", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "quinidine", "drug2": "amiodarone", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of amiodarone.", "severity": 4}
{"drug1": "droperidol", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "domperidone", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "domperidone", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "citalopram", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "cisapride", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Quinine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "cisapride", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "toremifene", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "flecainide", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "toremifene", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "promazine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "promazine", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "methadone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "citalopram", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "pimozide", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "promazine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "galanthamine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "galanthamine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "pimozide", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "domperidone", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "quinidine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "azithromycin", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "promazine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Artemether", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "flecainide", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "goserelin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "quinidine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "flecainide", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "flecainide", "drug2": "methadone", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "flecainide", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "granisetron", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "goserelin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "quinidine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "quinidine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "quinidine", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "quinidine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "disopyramide", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "ceritinib", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "toremifene", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "Quinine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "toremifene", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "methadone", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "ondansetron", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Telavancin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "erythromycin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "cisapride", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "quinidine", "drug2": "Fosphenytoin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Fosphenytoin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "promazine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "droperidol", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Quinine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "quetiapine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "propafenone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "propafenone", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "azithromycin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "furosemide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of furosemide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "erythromycin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "cisapride", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Artemether", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Artemether.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "cisapride", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "azithromycin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "promazine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Asenapine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "haloperidol", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "sotalol", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "flecainide", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "flecainide", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "flecainide", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "pimozide", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Quinine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "sotalol", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Artemether", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Artemether", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Artemether", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "citalopram", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "chloroquine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "quinidine", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "droperidol", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "thioridazine", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "sotalol", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "citalopram", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "sotalol", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "sotalol", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "droperidol", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "granisetron", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "droperidol", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "methadone", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "erythromycin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Ibandronic Acid", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Ibandronic Acid may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Artemether", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "promazine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "domperidone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "hydrochlorothiazide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of hydrochlorothiazide.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "granisetron", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "quetiapine", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "promazine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "methadone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "promazine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "promazine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Quinine", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "goserelin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "chloroquine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Artemether", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "propafenone", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "ondansetron", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "flecainide", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "erythromycin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Asenapine", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "disopyramide", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "cisapride", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "toremifene", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "citalopram", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Quinine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Quinine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "citalopram", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "citalopram", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of citalopram.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "pimozide", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "quetiapine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "quetiapine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "domperidone", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "pimozide", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "promazine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "haloperidol", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Asenapine", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "haloperidol", "drug2": "fluoxetine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of fluoxetine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Zuclopenthixol", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Zuclopenthixol.", "severity": 4}
{"drug1": "isradipine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "isradipine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "pimozide", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Artemether", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "citalopram", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "quinidine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "ceritinib", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "sotalol", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "cisapride", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "sotalol", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "clozapine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "droperidol", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "granisetron", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "citalopram", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "pimozide", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "mifepristone", "drug2": "sotalol", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of sotalol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "quinidine", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "cisapride", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "cisapride", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "quetiapine", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Telavancin", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Artemether", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "mifepristone", "drug2": "anagrelide", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of anagrelide.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "pimozide", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "quetiapine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "pimozide", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "granisetron", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "fluoxetine", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of fluoxetine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "propofol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "chloroquine", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Artemether", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "granisetron", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Artemether", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "domperidone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "flecainide", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "flecainide", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "flecainide", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "toremifene", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "sotalol", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "ceritinib", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "droperidol", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "goserelin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "propafenone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Quinine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "erythromycin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "methadone", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "amantadine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "amantadine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "cisapride", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "promazine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "goserelin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "goserelin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "droperidol", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "domperidone", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Asenapine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "pimozide", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "sotalol", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "droperidol", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "cisapride", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "droperidol", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "pimozide", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "quinidine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Quinine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Artemether", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "propafenone", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "quinidine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "dolasetron", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "domperidone", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "methadone", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "bumetanide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of bumetanide.", "severity": 4}
{"drug1": "granisetron", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "ceritinib", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "sotalol", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "sotalol", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "sotalol", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "citalopram", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "sotalol", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "toremifene", "drug2": "methadone", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "citalopram", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "pimozide", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "droperidol", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "clozapine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "clozapine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "pimozide", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "pimozide", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "granisetron", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "sotalol", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "anagrelide", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "methadone", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "amiodarone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "Quinine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "domperidone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "chloroquine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "toremifene", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Quinine", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "quetiapine", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "pimozide", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "cisapride", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "flecainide", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Artemether", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "dolasetron", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "quinidine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "quinidine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "methadone", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "flecainide", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "toremifene", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "sotalol", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "anagrelide", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "toremifene", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "goserelin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "sotalol", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "clozapine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "pentamidine", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "droperidol", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "methadone", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "pimozide", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Artemether", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "toremifene", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "goserelin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "goserelin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "granisetron", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "methadone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Iloperidone", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Iloperidone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "azithromycin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "cisapride", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "granisetron", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Asenapine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "methadone", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "toremifene", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "goserelin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "goserelin", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "cisapride", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "cisapride", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "methadone", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "cisapride", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "anagrelide", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "granisetron", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "toremifene", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of toremifene.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "disopyramide", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "quinidine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "goserelin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Telavancin", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "anagrelide", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "clozapine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "toremifene", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "granisetron", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Quinine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "cisapride", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "bepridil", "drug2": "cisapride", "interaction_type": 20, "interaction_text": "bepridil may increase the QTc-prolonging activities of cisapride.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Asenapine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Asenapine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "methadone", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "azithromycin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "azithromycin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "propafenone", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "anagrelide", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "promazine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "quinidine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "pentamidine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Artemether", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "sotalol", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "flecainide", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "haloperidol", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "apomorphine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "apomorphine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "clozapine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "domperidone", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "droperidol", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Artemether", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Artemether", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "propafenone", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "flecainide", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Telavancin", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "toremifene", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "domperidone", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "goserelin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "methadone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "methadone", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "pimozide", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "cisapride", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Artemether", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Artemether", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "itraconazole", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "itraconazole may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "citalopram", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "thioridazine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "ELIGLUSTAT", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of ELIGLUSTAT.", "severity": 4}
{"drug1": "droperidol", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "toremifene", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Quinine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "quetiapine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "domperidone", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "domperidone", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Artemether", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "citalopram", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "goserelin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "ceritinib", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "flecainide", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "sotalol", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "flecainide", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "granisetron", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "sotalol", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "flecainide", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "quinidine", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "domperidone", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "ceritinib", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "cisapride", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "toremifene", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "quinidine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Asenapine", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Asenapine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "promazine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "granisetron", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Quinine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Quinine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "granisetron", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "erythromycin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "erythromycin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "quinidine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "goserelin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "domperidone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Asenapine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "promazine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "pimozide", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "flecainide", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "dolasetron", "drug2": "methadone", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "sotalol", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "flecainide", "drug2": "amiodarone", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of amiodarone.", "severity": 4}
{"drug1": "sotalol", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "dolasetron", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "domperidone", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "dolasetron", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "flecainide", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Artemether", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "azithromycin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "domperidone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "droperidol", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Artemether", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "citalopram", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "flecainide", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Quinine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "sotalol", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "erythromycin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "azithromycin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "thioridazine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "thioridazine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "pimozide", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "methadone", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "promazine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "sotalol", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "domperidone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "granisetron", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "granisetron", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "goserelin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "ketoconazole", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "ketoconazole may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Quinine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "cisapride", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "promazine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "sotalol", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "propafenone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "domperidone", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "azithromycin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "goserelin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Indacaterol", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Indacaterol may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "domperidone", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "propafenone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "quinidine", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "goserelin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "erythromycin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "clozapine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "flecainide", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Vorinostat", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Vorinostat may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "disopyramide", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "methadone", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "thioridazine", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Asenapine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "toremifene", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "propafenone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "citalopram", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "citalopram", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "quetiapine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "clozapine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Dasatinib", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Dasatinib may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "cisapride", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Atomoxetine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Atomoxetine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Asenapine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "domperidone", "drug2": "propofol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "sotalol", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Artemether", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "sotalol", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "sotalol", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "chloroquine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "goserelin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "droperidol", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "domperidone", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Quinine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Artemether", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "toremifene", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "flecainide", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "propafenone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "toremifene", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "droperidol", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Asenapine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "quinidine", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "disopyramide", "drug2": "propofol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "azithromycin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "azithromycin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "methadone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "cisapride", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "cisapride", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Artemether", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "quetiapine", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "quetiapine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "propafenone", "drug2": "propofol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "ondansetron", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "toremifene", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "domperidone", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "domperidone", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "ondansetron", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "tacrolimus", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "tacrolimus may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "cisapride", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "trichlormethiazide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of trichlormethiazide.", "severity": 4}
{"drug1": "erythromycin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "droperidol", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "droperidol", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "pimozide", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "citalopram", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "azithromycin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "azithromycin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "citalopram", "drug2": "propofol", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "toremifene", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "azithromycin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "cisapride", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "granisetron", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "granisetron", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "disopyramide", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of disopyramide.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "quetiapine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "azithromycin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "goserelin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "goserelin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "goserelin", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Fosphenytoin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Fosphenytoin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "sotalol", "drug2": "methadone", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "sotalol", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "sotalol", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "promazine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "chloroquine", "drug2": "promazine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "fluconazole", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "fluconazole may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Artemether", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "domperidone", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Quinine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Quinine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Quinine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "haloperidol", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "flecainide", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "flecainide", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "flecainide", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "dolasetron", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "quinidine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Posaconazole", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Posaconazole may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "quinidine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "azithromycin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "granisetron", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "quinidine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "thioridazine", "drug2": "fluoxetine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of fluoxetine.", "severity": 4}
{"drug1": "droperidol", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "pimozide", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "citalopram", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "citalopram", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "citalopram", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "domperidone", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "domperidone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Retigabine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Retigabine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "amiodarone", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "pentamidine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "amiodarone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "promazine", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "quinidine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "promazine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "methadone", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "methadone", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Artemether", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "amiodarone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Salmeterol", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Salmeterol may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "propafenone", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "haloperidol", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "propafenone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Quinine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "pimozide", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Artemether", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "goserelin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "pimozide", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "granisetron", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "promazine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "chloroquine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Artemether", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Artemether", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "propafenone", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "haloperidol", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "quinidine", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "goserelin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "flecainide", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "toremifene", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "flecainide", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "clozapine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "quinidine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "disopyramide", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "droperidol", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "erythromycin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "erythromycin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "disopyramide", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "azithromycin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "disopyramide", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "ceritinib", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "famotidine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "famotidine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "erythromycin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "erythromycin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "pimozide", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "pimozide", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "chloroquine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "granisetron", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "granisetron", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "citalopram", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Quinine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "quetiapine", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "azithromycin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Vardenafil", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Vardenafil may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "propofol", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "methadone", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "granisetron", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "flecainide", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "domperidone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "dolasetron", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Artemether", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "promazine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "sotalol", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "dolasetron", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "goserelin", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "clozapine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "dolasetron", "drug2": "propofol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "droperidol", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "pimozide", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "quinidine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "quinidine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "domperidone", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "quinidine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "toremifene", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "amoxapine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "amoxapine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "domperidone", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Asenapine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "propafenone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ondansetron", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "pimozide", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "mifepristone", "drug2": "Flupentixol", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of Flupentixol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "promazine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "promazine", "drug2": "methadone", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Aripiprazole", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Aripiprazole may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "alfuzosin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "alfuzosin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Artemether", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "propafenone", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "haloperidol", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "flecainide", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "sotalol", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "sotalol", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "droperidol", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "droperidol", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "droperidol", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "norfloxacin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "norfloxacin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "histrelin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "histrelin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "propafenone", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "propafenone", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "disopyramide", "drug2": "promazine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "promazine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Telavancin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "flecainide", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "azithromycin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "sevoflurane", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "sevoflurane may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "granisetron", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "chlorothiazide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of chlorothiazide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "methadone", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "methadone", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "citalopram", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "promazine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "promazine", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "promazine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "domperidone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "sotalol", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "erythromycin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "erythromycin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "propafenone", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "dolasetron", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "goserelin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "dolasetron", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "promazine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "goserelin", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "quinidine", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of quinidine.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "thioridazine", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of thioridazine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "flecainide", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "goserelin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "thioridazine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "domperidone", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "ceritinib", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "anagrelide", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "thioridazine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Quinine", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "promazine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "citalopram", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "methadone", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "quinidine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "erythromycin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Quinine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "ondansetron", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "granisetron", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Artemether", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Telavancin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "domperidone", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "disopyramide", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "goserelin", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "quetiapine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "cisapride", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Artemether", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "cisapride", "drug2": "propofol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Quinine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Artemether", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "ceritinib", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "domperidone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "propafenone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "toremifene", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "citalopram", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "azithromycin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "azithromycin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "droperidol", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "clozapine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "goserelin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "clozapine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "clozapine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "chloroquine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "thiothixene", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "thiothixene may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "azithromycin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "goserelin", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "goserelin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Asenapine", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "granisetron", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "pimozide", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "flecainide", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "ondansetron", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "toremifene", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "citalopram", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "fluconazole", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "fluconazole may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "toremifene", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "flecainide", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "flecainide", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "toremifene", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "risperidone", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "risperidone may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "toremifene", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "toremifene", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "amiodarone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "quinidine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "pimozide", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "droperidol", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "droperidol", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "thioridazine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "quinidine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "quinidine", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "quinidine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "promazine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "clozapine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "methadone", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "methadone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Octreotide", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Octreotide may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "promazine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Quinine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "azithromycin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "granisetron", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "granisetron", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "propafenone", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "propafenone", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "goserelin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "granisetron", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "goserelin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Asenapine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Asenapine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "quetiapine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "ondansetron", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "promazine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "domperidone", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "flecainide", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "quinidine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "flecainide", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "granisetron", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "pimozide", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "clozapine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "droperidol", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "clozapine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "domperidone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "citalopram", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Quinine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "haloperidol", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "granisetron", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "clozapine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "erythromycin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "toremifene", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "erythromycin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Quinine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "goserelin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "clozapine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Telavancin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "erythromycin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "hydroflumethiazide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of hydroflumethiazide.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "cisapride", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "cisapride", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "granisetron", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "sotalol", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "propafenone", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "pimozide", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "azithromycin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "propafenone", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Quinine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "pimozide", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "pimozide", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "pimozide", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "citalopram", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "pentamidine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "flecainide", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "clozapine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "flecainide", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "sotalol", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "flecainide", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "pentamidine", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "sotalol", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "amiodarone", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "methadone", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "droperidol", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "thioridazine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "quinidine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Lurasidone", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Lurasidone.", "severity": 4}
{"drug1": "citalopram", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "propafenone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "propafenone", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "propafenone", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "propafenone", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "clozapine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "ETHACRYNIC ACID", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of ETHACRYNIC ACID.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "anagrelide", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "granisetron", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Salbutamol", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Salbutamol may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "domperidone", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "domperidone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "ondansetron", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "goserelin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "flecainide", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "pimozide", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Artemether", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "quinidine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "quinidine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "quinidine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "quinidine", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "propafenone", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "chloroquine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "goserelin", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "clozapine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Quinine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "TRIPTORELIN", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "TRIPTORELIN may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "clozapine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "disopyramide", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "pimozide", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "toremifene", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "clozapine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "citalopram", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "methadone", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "cisapride", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Artemether", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Artemether", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "chloroquine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Fosphenytoin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Fosphenytoin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "anagrelide", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "propafenone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "propafenone", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "citalopram", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "citalopram", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "ondansetron", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "amiodarone", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Quinine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "flecainide", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "propofol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "chloroquine", "drug2": "methadone", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "droperidol", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "chloroquine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Quinine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Mirabegron", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Mirabegron may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "goserelin", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "promazine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Artemether", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "ceritinib", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Artemether", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "olanzapine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "olanzapine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "promazine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "sotalol", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Lopinavir", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Lopinavir.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "pentamidine", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "sotalol", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "promazine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "quinidine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "citalopram", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "citalopram", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "pimozide", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "ondansetron", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "clomipramine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "clomipramine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "sotalol", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "domperidone", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "haloperidol", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "goserelin", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Artemether", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "trazodone", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "trazodone may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Quinine", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "granisetron", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "cisapride", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Sunitinib", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Sunitinib may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "pimozide", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "pimozide", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Artemether", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Quinine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "cisapride", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "flecainide", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "haloperidol", "drug2": "propofol", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "haloperidol", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "haloperidol", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "cisapride", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "dolasetron", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "granisetron", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "anagrelide", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "clozapine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "thioridazine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "chloroquine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "pimozide", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "chloroquine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "domperidone", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "ondansetron", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "clozapine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "citalopram", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "citalopram", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Dasatinib", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Dasatinib may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "erythromycin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "disopyramide", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "azithromycin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "quinidine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Halofantrine", "drug2": "Lumefantrine", "interaction_type": 20, "interaction_text": "Halofantrine may increase the QTc-prolonging activities of Lumefantrine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "cisapride", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "cisapride", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Degarelix", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Degarelix may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "cisapride", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Artemether", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Artemether", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "ondansetron", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "erythromycin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Quinine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "flecainide", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "cisapride", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "granisetron", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Asenapine", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Telavancin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "quinidine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "clozapine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "dolasetron", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "granisetron", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "sotalol", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "QUINETHAZONE", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of QUINETHAZONE.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "polythiazide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of polythiazide.", "severity": 4}
{"drug1": "flecainide", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "Asenapine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "sotalol", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "sotalol", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "domperidone", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "quinidine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Quinine", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "cisapride", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "toremifene", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "toremifene", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Telavancin", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "pentamidine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "pimozide", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "granisetron", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Levomepromazine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Levomepromazine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "citalopram", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "methadone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "promazine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "erythromycin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "amiodarone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "granisetron", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "granisetron", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "granisetron", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "astemizole", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "astemizole may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "promazine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "amiodarone", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of amiodarone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "granisetron", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "granisetron", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "goserelin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "goserelin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "clozapine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "droperidol", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "droperidol", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Telavancin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "toremifene", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "toremifene", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "ondansetron", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "erythromycin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Escitalopram", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Escitalopram.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "cisapride", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "domperidone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "cisapride", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "cisapride", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "pimozide", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "propafenone", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Quinine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "propofol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "quinidine", "drug2": "Tianeptine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Tianeptine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "goserelin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "promazine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "amiodarone", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Asenapine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "clozapine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "quinidine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "methadone", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "cisapride", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "cisapride", "drug2": "methadone", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "sotalol", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "foscarnet", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "foscarnet may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "sotalol", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "quinidine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "disopyramide", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "disopyramide", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "domperidone", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "ceritinib", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "toremifene", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "citalopram", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "citalopram", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Quinine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Quinine", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Quinine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Artemether", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "droperidol", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "thioridazine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "methadone", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "promazine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Torasemide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Torasemide.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "cisapride", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "cisapride", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "quinidine", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "toremifene", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "flecainide", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "anagrelide", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "methadone", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "cisapride", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "granisetron", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "pimozide", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "pimozide", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "methadone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "methadone", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "haloperidol", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "domperidone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Artemether", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "goserelin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "goserelin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "quinidine", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Artemether", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "quinidine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "quinidine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "flecainide", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "azithromycin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "toremifene", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "toremifene", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "methadone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "cisapride", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "methadone", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "pimozide", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "pimozide", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "disopyramide", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "citalopram", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Asenapine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "toremifene", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "propafenone", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ondansetron", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Dofetilide", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Dofetilide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "clozapine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "droperidol", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "cisapride", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "granisetron", "drug2": "promazine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "azithromycin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "promazine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "quetiapine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "quinidine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "propafenone", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "goserelin", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "sotalol", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "domperidone", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "pimozide", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "anagrelide", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Asenapine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Quinine", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Quinine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "pentamidine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "citalopram", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "chloroquine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "domperidone", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "citalopram", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "clozapine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "sotalol", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "sotalol", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "disopyramide", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "droperidol", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "clozapine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "clozapine", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "clozapine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "droperidol", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "propafenone", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "propafenone", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "methadone", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "quinidine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "pimozide", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "cisapride", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "nelfinavir", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "nelfinavir may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Fosphenytoin", "drug2": "disopyramide", "interaction_type": 20, "interaction_text": "Fosphenytoin may increase the QTc-prolonging activities of disopyramide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "methyclothiazide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of methyclothiazide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "quetiapine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "granisetron", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "quinidine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "goserelin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Quinine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "goserelin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Quinine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "goserelin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "cisapride", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "pimozide", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "quetiapine", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "goserelin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "chloroquine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "flecainide", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Artemether", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "propafenone", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "clozapine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "flecainide", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "ondansetron", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "domperidone", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "flecainide", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "clozapine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "toremifene", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "toremifene", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "toremifene", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "flecainide", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "methadone", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "cisapride", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "droperidol", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "cisapride", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "disopyramide", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Telavancin", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "anagrelide", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of anagrelide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "ondansetron", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "azithromycin", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "promazine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Asenapine", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "propafenone", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "quetiapine", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "azithromycin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "cisapride", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "droperidol", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "methadone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "pimozide", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "promazine", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Quinine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "sotalol", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Quinine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "sotalol", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Quinine", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "quinidine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "quinidine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Flupentixol", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Flupentixol.", "severity": 4}
{"drug1": "citalopram", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "methadone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "granisetron", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "tacrolimus", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "tacrolimus may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "clozapine", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "flecainide", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "sotalol", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Quinine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "sotalol", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "pimozide", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "pentamidine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "citalopram", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "granisetron", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "droperidol", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "citalopram", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "domperidone", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "pimozide", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "pimozide", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "citalopram", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "erythromycin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "toremifene", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "toremifene", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of BENDROFLUMETHIAZIDE.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Lumefantrine", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Lumefantrine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "domperidone", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "domperidone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "anagrelide", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "propafenone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "domperidone", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "pimozide", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "toremifene", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "chloroquine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "chloroquine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "mifepristone", "drug2": "PROCAINAMIDE", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of PROCAINAMIDE.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "propafenone", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "quinidine", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "haloperidol", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "flecainide", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "flecainide", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "flecainide", "drug2": "propofol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "sotalol", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "amiodarone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "sotalol", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "clozapine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "erythromycin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "droperidol", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "methadone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "quinidine", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "disopyramide", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "disopyramide", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Quinine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "goserelin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "pimozide", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "clozapine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "thioridazine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "cisapride", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "cisapride", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "fluoxetine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of fluoxetine.", "severity": 4}
{"drug1": "promazine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "domperidone", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "pimozide", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "methadone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "ondansetron", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "droperidol", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "promazine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "promazine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "azithromycin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "amiodarone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "goserelin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "amiodarone", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "anagrelide", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "methadone", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "protriptyline", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "protriptyline may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "sotalol", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "droperidol", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "promazine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "promazine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "promazine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Quinine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "RANOLAZINE", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "RANOLAZINE may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Artemether", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "quinidine", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "dolasetron", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "droperidol", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "clozapine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "granisetron", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "flecainide", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "goserelin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "goserelin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "quinidine", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "methadone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "ondansetron", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "chloroquine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "pimozide", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "pentamidine", "drug2": "promazine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "pimozide", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "granisetron", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "granisetron", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "toremifene", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "droperidol", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "domperidone", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "domperidone", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Telavancin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "clozapine", "drug2": "methadone", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "toremifene", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "droperidol", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "felbamate", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "felbamate may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "granisetron", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "citalopram", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "promazine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Quinine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "propafenone", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "anagrelide", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Artemether", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Quinine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "promazine", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "promazine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "propafenone", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "flecainide", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "sotalol", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "sotalol", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "clozapine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "pentamidine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "droperidol", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "clozapine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Artemether", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Artemether", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "cisapride", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "quinidine", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "propafenone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "domperidone", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Rilpivirine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Rilpivirine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "pentamidine", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "granisetron", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "granisetron", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "methadone", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "clozapine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "granisetron", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "toremifene", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "promazine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "methadone", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Asenapine", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "methadone", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "methadone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "toremifene", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "azithromycin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Quinine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "azithromycin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "granisetron", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Lurasidone", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Lurasidone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "pentamidine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "granisetron", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "promazine", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "propafenone", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "sotalol", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Pasireotide", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Pasireotide may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "domperidone", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "domperidone", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Asenapine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "domperidone", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "goserelin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "goserelin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "haloperidol", "drug2": "promazine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "ondansetron", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "granisetron", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Artemether", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "flecainide", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "sotalol", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "citalopram", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "goserelin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "anagrelide", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "promazine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Quinine", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "propafenone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "granisetron", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "toremifene", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "cisapride", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "granisetron", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "methadone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "anagrelide", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "methadone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "citalopram", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Artemether", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "azithromycin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "propafenone", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "promazine", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "tacrolimus", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of tacrolimus.", "severity": 4}
{"drug1": "pentamidine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Artemether", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Artemether", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "domperidone", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "flecainide", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "sotalol", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "sotalol", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "sotalol", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "clozapine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "domperidone", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "droperidol", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Quinine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Artemether", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "propafenone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "domperidone", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "goserelin", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "goserelin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "methadone", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "clozapine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "terbutaline", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "terbutaline may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Telavancin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Telavancin", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "quetiapine", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of quetiapine.", "severity": 4}
{"drug1": "Artemether", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "propafenone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "amiodarone", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "quetiapine", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "goserelin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "methadone", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "methadone", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "quetiapine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "promazine", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "ondansetron", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "domperidone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "propofol", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "domperidone", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "maprotiline", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "maprotiline may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "sotalol", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "domperidone", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "sotalol", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "pimozide", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "goserelin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "ondansetron", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "domperidone", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "cisapride", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "ceritinib", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "PROCAINAMIDE", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of PROCAINAMIDE.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "goserelin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "quinidine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "pimozide", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "anagrelide", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Quinine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "methadone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "granisetron", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "citalopram", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "quinidine", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "citalopram", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "imipramine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "imipramine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "citalopram", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "sotalol", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Asenapine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Quinine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "quetiapine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "promazine", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "domperidone", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "sotalol", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "sotalol", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "flecainide", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "sotalol", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "anagrelide", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "droperidol", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Quinine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Quinine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Quinine", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Quinine", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "goserelin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "propafenone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "chloroquine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "pimozide", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "cisapride", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "amiodarone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Telavancin", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "propafenone", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "chlorthalidone", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of chlorthalidone.", "severity": 4}
{"drug1": "azithromycin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Artemether", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Artemether", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "sotalol", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "sotalol", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "methadone", "drug2": "propofol", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "propafenone", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "ondansetron", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "disopyramide", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "dolasetron", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "pimozide", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "chloroquine", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Artemether", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "ondansetron", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "disopyramide", "drug2": "josamycin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of josamycin.", "severity": 4}
{"drug1": "domperidone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "dolasetron", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "cisapride", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "droperidol", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "pentamidine", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "flecainide", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "propafenone", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "quinidine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "droperidol", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Asenapine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "toremifene", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "toremifene", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "mifepristone", "drug2": "TETRABENAZINE", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of TETRABENAZINE.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "toremifene", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "citalopram", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "propofol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "toremifene", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "toremifene", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "granisetron", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "flecainide", "drug2": "promazine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Asenapine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "haloperidol", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "sotalol", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "promazine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "citalopram", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "promazine", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "erythromycin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "chloroquine", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "quinidine", "drug2": "Lopinavir", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Lopinavir.", "severity": 4}
{"drug1": "chloroquine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Quinine", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Quinine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Artemether", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Telavancin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "toremifene", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "sotalol", "drug2": "propofol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "methadone", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "toremifene", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "toremifene", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "flecainide", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "quinidine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "promethazine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "promethazine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "desipramine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "desipramine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Telavancin", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "clozapine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "cisapride", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "cisapride", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "mefloquine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "mefloquine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Artemether", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "promazine", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Artemether", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "granisetron", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "propafenone", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "sotalol", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "domperidone", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "domperidone", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "dolasetron", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "goserelin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "pimozide", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "amiodarone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "pimozide", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "granisetron", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "granisetron", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "chloroquine", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "promazine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Artemether", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "Artemether", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "propafenone", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "domperidone", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "domperidone", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "quinidine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "mifepristone", "drug2": "Paliperidone", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of Paliperidone.", "severity": 4}
{"drug1": "goserelin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "flecainide", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "ceritinib", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "erythromycin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "promazine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "thioridazine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "propofol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "pentamidine", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "Quinine", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "domperidone", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "quinidine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "citalopram", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "azithromycin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "ceritinib", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Ibutilide", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Ibutilide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "cisapride", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Asenapine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "methadone", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Asenapine", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "citalopram", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "promazine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "dolasetron", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "sotalol", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "sotalol", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "toremifene", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "promazine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "dolasetron", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "promazine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "quinidine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "domperidone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Quinine", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Quinine", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "flecainide", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "sotalol", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "clozapine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "toremifene", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "toremifene", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "granisetron", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "droperidol", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "pimozide", "drug2": "fluoxetine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of fluoxetine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "citalopram", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "propafenone", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "quinidine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "goserelin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "thioridazine", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "domperidone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "propafenone", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "domperidone", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "pentamidine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "pimozide", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "toremifene", "drug2": "promazine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "ondansetron", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "toremifene", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "clozapine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "metoclopramide", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "metoclopramide may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "clozapine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "thioridazine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "thioridazine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "promazine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "Asenapine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "methadone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "amiodarone", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "cisapride", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "promazine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "domperidone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "promazine", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "ondansetron", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "toremifene", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "toremifene", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "cisapride", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "pentamidine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Artemether", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "granisetron", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "granisetron", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "granisetron", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "granisetron", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "clozapine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "pentamidine", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "disopyramide", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Artemether", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "quinidine", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "propafenone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "flecainide", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "goserelin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "clozapine", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "flecainide", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "flecainide", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "dolasetron", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "disopyramide", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "domperidone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "domperidone", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "flecainide", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "thioridazine", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "pentamidine", "drug2": "methadone", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "pentamidine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Vilanterol", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Vilanterol may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "hydroxyzine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "hydroxyzine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "propafenone", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "disopyramide", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Atazanavir", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Atazanavir.", "severity": 4}
{"drug1": "Telavancin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "citalopram", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "clozapine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Asenapine", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Asenapine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "ceritinib", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "granisetron", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "clozapine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "cisapride", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "trazodone", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "trazodone may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "methadone", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "metolazone", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of metolazone.", "severity": 4}
{"drug1": "Asenapine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "haloperidol", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "domperidone", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of domperidone.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "quetiapine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "azithromycin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Vandetanib", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Vandetanib.", "severity": 4}
{"drug1": "granisetron", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "goserelin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "goserelin", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Fingolimod", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Fingolimod may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "sotalol", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "sotalol", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "cisapride", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "propafenone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "sotalol", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Artemether", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "flecainide", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "sotalol", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Artemether", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Artemether", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Quinine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "flecainide", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "flecainide", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "toremifene", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "sotalol", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "droperidol", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "quinidine", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "domperidone", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "domperidone", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "amiodarone", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of amiodarone.", "severity": 4}
{"drug1": "quinidine", "drug2": "Crizotinib", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Crizotinib.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "toremifene", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "domperidone", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "domperidone", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "methadone", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "propafenone", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "promazine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "promazine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "cisapride", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "pimozide", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "pentamidine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "anagrelide", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "promazine", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "anagrelide", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "pentamidine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "quinidine", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "erythromycin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "erythromycin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "ondansetron", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "haloperidol", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Artemether", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "methadone", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "promazine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "cisapride", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "ondansetron", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Artemether", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "Paliperidone", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of Paliperidone.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "domperidone", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "haloperidol", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "goserelin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "sotalol", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "cisapride", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "clozapine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "thioridazine", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Artemether", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "DESFLURANE", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "DESFLURANE may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "propafenone", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "propafenone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "flecainide", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "ajmaline", "drug2": "amiodarone", "interaction_type": 20, "interaction_text": "ajmaline may increase the QTc-prolonging activities of amiodarone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "Telavancin", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "toremifene", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "erythromycin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Quinine", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "goserelin", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "cisapride", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "methadone", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "sotalol", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Quinine", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "droperidol", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "granisetron", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "goserelin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "citalopram", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "pimozide", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "ondansetron", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Asenapine", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "risperidone", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of risperidone.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "granisetron", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "flecainide", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "goserelin", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "goserelin", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "ketoconazole", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of ketoconazole.", "severity": 4}
{"drug1": "ondansetron", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "ritonavir", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "ritonavir may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "cisapride", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "domperidone", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "domperidone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "domperidone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "cisapride", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "sotalol", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "sotalol", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "ceritinib", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "ceritinib", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "ceritinib", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "granisetron", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "dolasetron", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "pentamidine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "citalopram", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "disopyramide", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "promazine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "ondansetron", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "ondansetron", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "erythromycin", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Quinine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ondansetron", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "propafenone", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "propafenone", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "granisetron", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "anagrelide", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Artemether", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Artemether", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "droperidol", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "quinidine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "propafenone", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "paroxetine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "paroxetine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "dolasetron", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "dolasetron", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "domperidone", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "goserelin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Artemether", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "methadone", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "Artemether", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "citalopram", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "clozapine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "droperidol", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "thioridazine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "domperidone", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "domperidone", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "chloroquine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "chloroquine", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "pentamidine", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Telavancin", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "toremifene", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "toremifene", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "domperidone", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "toremifene", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "droperidol", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "goserelin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "pimozide", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "cisapride", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "methadone", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "citalopram", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "citalopram", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Telithromycin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Telithromycin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "quetiapine", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "cisapride", "drug2": "promazine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "quinidine", "drug2": "Dothiepin", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Dothiepin.", "severity": 4}
{"drug1": "quetiapine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "quetiapine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "granisetron", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Asenapine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "propafenone", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Quinine", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "Quinine", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "goserelin", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "MOEXIPRIL", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "MOEXIPRIL may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Quinine", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "mifepristone", "drug2": "Ibutilide", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of Ibutilide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "flecainide", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "anagrelide", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "quetiapine", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "clozapine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "cisapride", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "goserelin", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "ondansetron", "drug2": "promazine", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "flecainide", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "flecainide", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "flecainide", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "mifepristone", "drug2": "arsenic trioxide", "interaction_type": 20, "interaction_text": "mifepristone may increase the QTc-prolonging activities of arsenic trioxide.", "severity": 4}
{"drug1": "flecainide", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "toremifene", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "toremifene", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "amiodarone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "pentamidine", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Dabrafenib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Dabrafenib.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "thioridazine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "granisetron", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "quinidine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "citalopram", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "promazine", "drug2": "propofol", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "erythromycin", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Quinine", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "propofol", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "TETRABENAZINE", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of TETRABENAZINE.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "granisetron", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "promazine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "indapamide", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "indapamide may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Asenapine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "promazine", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "itraconazole", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of itraconazole.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "isoflurane", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "isoflurane may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Halofantrine", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "Halofantrine may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "anagrelide", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "flecainide", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "anagrelide", "drug2": "propofol", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "cisapride", "drug2": "RANOLAZINE", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of RANOLAZINE.", "severity": 4}
{"drug1": "pimozide", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "pimozide", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Quinine", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "Telavancin", "drug2": "SAQUINAVIR", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of SAQUINAVIR.", "severity": 4}
{"drug1": "Telavancin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "Telavancin", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "Quinine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "quinidine", "drug2": "cyclobenzaprine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of cyclobenzaprine.", "severity": 4}
{"drug1": "quinidine", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "clozapine", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "propafenone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "granisetron", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "granisetron", "drug2": "methadone", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "dolasetron", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "clozapine", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "erythromycin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "cisapride", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Telavancin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "droperidol", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "droperidol", "drug2": "Dasatinib", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Dasatinib.", "severity": 4}
{"drug1": "clozapine", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "pimozide", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "chloroquine", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "chloroquine", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "pimozide", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "ceritinib", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Sorafenib", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Sorafenib.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "domperidone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "domperidone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "thioridazine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "citalopram", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "citalopram", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "toremifene", "drug2": "Telavancin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Telavancin.", "severity": 4}
{"drug1": "erythromycin", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "amiodarone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "amiodarone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "erythromycin", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "lithium ion", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "lithium ion may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "erythromycin", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "tizanidine", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "tizanidine may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "cisapride", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "quetiapine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "Artemether", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Asenapine", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "propafenone", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "Quinine", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "goserelin", "drug2": "nelfinavir", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of nelfinavir.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "methadone", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "flecainide", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "flecainide", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "hydroxyzine", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of hydroxyzine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "cisapride", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of cisapride.", "severity": 4}
{"drug1": "granisetron", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "clozapine", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of clozapine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "droperidol", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "quetiapine", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "clomipramine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of clomipramine.", "severity": 4}
{"drug1": "promazine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "dolasetron", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "flecainide", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "PRIMAQUINE", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of PRIMAQUINE.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Mirabegron", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Mirabegron.", "severity": 4}
{"drug1": "Dronedarone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Dronedarone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "LEVOFLOXACIN", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of LEVOFLOXACIN.", "severity": 4}
{"drug1": "sotalol", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Vemurafenib may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "sotalol", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "granisetron", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "azithromycin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "droperidol", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "Asenapine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Bedaquiline", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Bedaquiline may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "methadone", "drug2": "olanzapine", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of olanzapine.", "severity": 4}
{"drug1": "methadone", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "Panobinostat may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "quinidine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "propafenone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "ondansetron", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "citalopram", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Fingolimod", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Fingolimod.", "severity": 4}
{"drug1": "propafenone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "promazine", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of promazine.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "clozapine", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "granisetron", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "pimozide", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "granisetron", "drug2": "Perfluoropropane", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of Perfluoropropane.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "promazine", "drug2": "MOEXIPRIL", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of MOEXIPRIL.", "severity": 4}
{"drug1": "methadone", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "promazine", "drug2": "tizanidine", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of tizanidine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Gadobenic acid", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "Gadobenic acid may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "sevoflurane", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of sevoflurane.", "severity": 4}
{"drug1": "ondansetron", "drug2": "formoterol", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of formoterol.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "Aripiprazole", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of Aripiprazole.", "severity": 4}
{"drug1": "Telavancin", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "haloperidol", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "ritonavir", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of ritonavir.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "sotalol", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "methadone", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "methadone may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "promazine", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "promazine", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "PROCAINAMIDE may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "Telavancin", "drug2": "clarithromycin", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of clarithromycin.", "severity": 4}
{"drug1": "Quinine", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "goserelin", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Artemether", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "ELIGLUSTAT", "drug2": "tolterodine", "interaction_type": 20, "interaction_text": "ELIGLUSTAT may increase the QTc-prolonging activities of tolterodine.", "severity": 4}
{"drug1": "Quinine", "drug2": "promethazine", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of promethazine.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "haloperidol", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "flecainide", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "haloperidol", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "disopyramide", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Telavancin", "drug2": "methadone", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of methadone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "toremifene", "drug2": "propofol", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "trazodone", "drug2": "Lopinavir", "interaction_type": 20, "interaction_text": "trazodone may increase the QTc-prolonging activities of Lopinavir.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "isradipine", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of isradipine.", "severity": 4}
{"drug1": "clozapine", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "sotalol", "drug2": "Indacaterol", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of Indacaterol.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "azithromycin", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "azithromycin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "azithromycin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "clozapine", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "ondansetron", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Panobinostat", "interaction_type": 20, "interaction_text": "anagrelide may increase the QTc-prolonging activities of Panobinostat.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "trazodone", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of trazodone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "disopyramide", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "chloroquine", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "pimozide", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Eribulin", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Eribulin.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "ondansetron", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "ondansetron may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Pasireotide", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Pasireotide.", "severity": 4}
{"drug1": "sotalol", "drug2": "indapamide", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of indapamide.", "severity": 4}
{"drug1": "toremifene", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "clozapine", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "clozapine may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Salbutamol", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Salbutamol.", "severity": 4}
{"drug1": "Ivabradine", "drug2": "pimozide", "interaction_type": 20, "interaction_text": "Ivabradine may increase the QTc-prolonging activities of pimozide.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Bortezomib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Bortezomib.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "imipramine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of imipramine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "Fosphenytoin", "interaction_type": 20, "interaction_text": "ciprofloxacin may increase the QTc-prolonging activities of Fosphenytoin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "cisapride", "drug2": "trimipramine", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of trimipramine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "mefloquine", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of mefloquine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "azithromycin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of azithromycin.", "severity": 4}
{"drug1": "Artemether", "drug2": "famotidine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of famotidine.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "propafenone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "propafenone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "granisetron", "interaction_type": 20, "interaction_text": "Zuclopenthixol may increase the QTc-prolonging activities of granisetron.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Pazopanib", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of Pazopanib.", "severity": 4}
{"drug1": "Lopinavir", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "Lopinavir may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "Artemether", "drug2": "Degarelix", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Degarelix.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "Asenapine", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Asenapine", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "ciprofloxacin", "interaction_type": 20, "interaction_text": "Ibutilide may increase the QTc-prolonging activities of ciprofloxacin.", "severity": 4}
{"drug1": "propafenone", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "propafenone", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "Quinine", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "propafenone", "drug2": "ondansetron", "interaction_type": 20, "interaction_text": "propafenone may increase the QTc-prolonging activities of ondansetron.", "severity": 4}
{"drug1": "erythromycin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "erythromycin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "haloperidol", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "haloperidol may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Escitalopram may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "erythromycin", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of erythromycin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Lenvatinib may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "diphenhydramine", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of diphenhydramine.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "maprotiline", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of maprotiline.", "severity": 4}
{"drug1": "Perfluoropropane", "drug2": "Salmeterol", "interaction_type": 20, "interaction_text": "Perfluoropropane may increase the QTc-prolonging activities of Salmeterol.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "fluconazole", "interaction_type": 20, "interaction_text": "Crizotinib may increase the QTc-prolonging activities of fluconazole.", "severity": 4}
{"drug1": "Quinine", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "Quinine may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "clarithromycin", "drug2": "terbutaline", "interaction_type": 20, "interaction_text": "clarithromycin may increase the QTc-prolonging activities of terbutaline.", "severity": 4}
{"drug1": "pimozide", "drug2": "Bedaquiline", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Bedaquiline.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "granisetron", "drug2": "propofol", "interaction_type": 20, "interaction_text": "granisetron may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "goserelin", "drug2": "Vorinostat", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of Vorinostat.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Lenvatinib", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of Lenvatinib.", "severity": 4}
{"drug1": "Asenapine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "cisapride", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "chloroquine", "interaction_type": 20, "interaction_text": "Vandetanib may increase the QTc-prolonging activities of chloroquine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Telavancin", "drug2": "felbamate", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of felbamate.", "severity": 4}
{"drug1": "quetiapine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "quetiapine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "Artemether", "drug2": "Levomepromazine", "interaction_type": 20, "interaction_text": "Artemether may increase the QTc-prolonging activities of Levomepromazine.", "severity": 4}
{"drug1": "Eribulin", "drug2": "mifepristone", "interaction_type": 20, "interaction_text": "Eribulin may increase the QTc-prolonging activities of mifepristone.", "severity": 4}
{"drug1": "sotalol", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "pentamidine", "drug2": "doxepin", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of doxepin.", "severity": 4}
{"drug1": "goserelin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "goserelin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "flecainide", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "SAQUINAVIR", "drug2": "pentamidine", "interaction_type": 20, "interaction_text": "SAQUINAVIR may increase the QTc-prolonging activities of pentamidine.", "severity": 4}
{"drug1": "dolasetron", "drug2": "droperidol", "interaction_type": 20, "interaction_text": "dolasetron may increase the QTc-prolonging activities of droperidol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "dolasetron", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of dolasetron.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "isoflurane", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of isoflurane.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "Dofetilide may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "flecainide", "drug2": "Arformoterol", "interaction_type": 20, "interaction_text": "flecainide may increase the QTc-prolonging activities of Arformoterol.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "disopyramide may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "ofloxacin may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "flecainide", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of flecainide.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Sunitinib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Sunitinib.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Posaconazole", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of Posaconazole.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "amantadine", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of amantadine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "metronidazole", "interaction_type": 20, "interaction_text": "PRIMAQUINE may increase the QTc-prolonging activities of metronidazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "mirtazapine", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of mirtazapine.", "severity": 4}
{"drug1": "sotalol", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "sotalol may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "toremifene", "drug2": "Treprostinil", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of Treprostinil.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "moxifloxacin", "interaction_type": 20, "interaction_text": "TETRABENAZINE may increase the QTc-prolonging activities of moxifloxacin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "ceritinib", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of ceritinib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "galanthamine", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of galanthamine.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Rilpivirine", "interaction_type": 20, "interaction_text": "chloroquine may increase the QTc-prolonging activities of Rilpivirine.", "severity": 4}
{"drug1": "pentamidine", "drug2": "nortriptyline", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of nortriptyline.", "severity": 4}
{"drug1": "pentamidine", "drug2": "amoxapine", "interaction_type": 20, "interaction_text": "pentamidine may increase the QTc-prolonging activities of amoxapine.", "severity": 4}
{"drug1": "pimozide", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "droperidol", "drug2": "nicardipine", "interaction_type": 20, "interaction_text": "droperidol may increase the QTc-prolonging activities of nicardipine.", "severity": 4}
{"drug1": "citalopram", "drug2": "Retigabine", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of Retigabine.", "severity": 4}
{"drug1": "ceritinib", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Pazopanib may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Gadobenic acid", "interaction_type": 20, "interaction_text": "fluoxetine may increase the QTc-prolonging activities of Gadobenic acid.", "severity": 4}
{"drug1": "citalopram", "drug2": "norfloxacin", "interaction_type": 20, "interaction_text": "citalopram may increase the QTc-prolonging activities of norfloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "DESFLURANE", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of DESFLURANE.", "severity": 4}
{"drug1": "sulfisoxazole", "drug2": "Octreotide", "interaction_type": 20, "interaction_text": "sulfisoxazole may increase the QTc-prolonging activities of Octreotide.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Voriconazole", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of Voriconazole.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Ivabradine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Ivabradine.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "haloperidol", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of haloperidol.", "severity": 4}
{"drug1": "cisapride", "drug2": "Lapatinib", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of Lapatinib.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "ofloxacin", "interaction_type": 20, "interaction_text": "Nilotinib may increase the QTc-prolonging activities of ofloxacin.", "severity": 4}
{"drug1": "ceritinib", "drug2": "foscarnet", "interaction_type": 20, "interaction_text": "ceritinib may increase the QTc-prolonging activities of foscarnet.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Atomoxetine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Atomoxetine.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "amitriptyline", "interaction_type": 20, "interaction_text": "Lumefantrine may increase the QTc-prolonging activities of amitriptyline.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "venlafaxine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of venlafaxine.", "severity": 4}
{"drug1": "Telavancin", "drug2": "trimethoprim", "interaction_type": 20, "interaction_text": "Telavancin may increase the QTc-prolonging activities of trimethoprim.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Gemifloxacin", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of Gemifloxacin.", "severity": 4}
{"drug1": "toremifene", "drug2": "lithium ion", "interaction_type": 20, "interaction_text": "toremifene may increase the QTc-prolonging activities of lithium ion.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "desipramine", "interaction_type": 20, "interaction_text": "Iloperidone may increase the QTc-prolonging activities of desipramine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Vardenafil", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Vardenafil.", "severity": 4}
{"drug1": "erythromycin", "drug2": "goserelin", "interaction_type": 20, "interaction_text": "erythromycin may increase the QTc-prolonging activities of goserelin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "paroxetine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of paroxetine.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "histrelin", "interaction_type": 20, "interaction_text": "Asenapine may increase the QTc-prolonging activities of histrelin.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "metoclopramide", "interaction_type": 20, "interaction_text": "LEVOFLOXACIN may increase the QTc-prolonging activities of metoclopramide.", "severity": 4}
{"drug1": "thioridazine", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "quinidine", "drug2": "sulfamethoxazole", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of sulfamethoxazole.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "thioridazine may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "Telithromycin", "drug2": "sulfisoxazole", "interaction_type": 20, "interaction_text": "Telithromycin may increase the QTc-prolonging activities of sulfisoxazole.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "apomorphine", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of apomorphine.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "Ibandronic Acid", "interaction_type": 20, "interaction_text": "Gemifloxacin may increase the QTc-prolonging activities of Ibandronic Acid.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "TRIPTORELIN", "interaction_type": 20, "interaction_text": "moxifloxacin may increase the QTc-prolonging activities of TRIPTORELIN.", "severity": 4}
{"drug1": "cisapride", "drug2": "thiothixene", "interaction_type": 20, "interaction_text": "cisapride may increase the QTc-prolonging activities of thiothixene.", "severity": 4}
{"drug1": "pimozide", "drug2": "propofol", "interaction_type": 20, "interaction_text": "pimozide may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "propofol", "interaction_type": 20, "interaction_text": "Flupentixol may increase the QTc-prolonging activities of propofol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "tamoxifen", "interaction_type": 20, "interaction_text": "Paliperidone may increase the QTc-prolonging activities of tamoxifen.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "propafenone", "interaction_type": 20, "interaction_text": "arsenic trioxide may increase the QTc-prolonging activities of propafenone.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "protriptyline", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of protriptyline.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "alfuzosin", "interaction_type": 20, "interaction_text": "Ziprasidone may increase the QTc-prolonging activities of alfuzosin.", "severity": 4}
{"drug1": "promazine", "drug2": "sertraline", "interaction_type": 20, "interaction_text": "promazine may increase the QTc-prolonging activities of sertraline.", "severity": 4}
{"drug1": "quinidine", "drug2": "OLODATEROL", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of OLODATEROL.", "severity": 4}
{"drug1": "quinidine", "drug2": "Vilanterol", "interaction_type": 20, "interaction_text": "quinidine may increase the QTc-prolonging activities of Vilanterol.", "severity": 4}
{"drug1": "Atracurium besylate", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "diltiazem", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of diltiazem.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "xylometazoline", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of xylometazoline.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nitrous oxide", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nitrous oxide.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "DESFLURANE", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of DESFLURANE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "Epirubicin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Epirubicin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "netilmicin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of netilmicin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Pinaverium", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Pinaverium.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "decamethonium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "VERAPAMIL", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of VERAPAMIL.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "paromomycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of paromomycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "streptomycin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "streptomycin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "metrizamide", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "metrizamide may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Colistimethate", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Colistimethate may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "decamethonium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "kanamycin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "kanamycin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "plicamycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of plicamycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "barnidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of barnidipine.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "decamethonium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nimodipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nimodipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Spectinomycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of Spectinomycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Pregabalin", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Pregabalin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nicardipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nicardipine.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "IDARUBICIN may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "isradipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of isradipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "TRICHLOROETHYLENE", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "decamethonium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Valrubicin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of Valrubicin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "pancuronium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Epirubicin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of Epirubicin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "gabapentin", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of gabapentin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "bepridil", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of bepridil.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nifedipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nifedipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nitrendipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nitrendipine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Amrinone", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Amrinone.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nitrendipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nitrendipine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "plicamycin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "plicamycin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "tobramycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of tobramycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "isradipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of isradipine.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "streptozocin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "streptozocin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "tobramycin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "tobramycin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "isoflurane", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of isoflurane.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Pregabalin", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Pregabalin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "decamethonium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "pancuronium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "TRICHLOROETHYLENE", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "cilnidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of cilnidipine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Benidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Benidipine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Azelnidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Azelnidipine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Lacidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Lacidipine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Efonidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Efonidipine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "xylometazoline", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of xylometazoline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "manidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of manidipine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nitrous oxide", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nitrous oxide.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nisoldipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nisoldipine.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "Amrubicin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Amrubicin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Phenelzine", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of Phenelzine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Amrubicin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of Amrubicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Lacidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Lacidipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Efonidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Efonidipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "cilnidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of cilnidipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Azelnidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Azelnidipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Benidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Benidipine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "manidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of manidipine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "spironolactone", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of spironolactone.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "netilmicin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "netilmicin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nimodipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nimodipine.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "amikacin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "amikacin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "halothane", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of halothane.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nimesulide", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nimesulide.", "severity": 2}
{"drug1": "pancuronium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Pinaverium", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Pinaverium.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "decamethonium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "streptomycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of streptomycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Lercanidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Lercanidipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "diltiazem", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of diltiazem.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "Valrubicin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Valrubicin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "daunorubicin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "eperisone", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of eperisone.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "sevoflurane", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of sevoflurane.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "decamethonium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "gabapentin", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of gabapentin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "methoxyflurane", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of methoxyflurane.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "pancuronium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "felodipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of felodipine.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "daunorubicin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of daunorubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Amrinone", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Amrinone.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "sevoflurane", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of sevoflurane.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nilvadipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nilvadipine.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "cinnarizine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of cinnarizine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "enflurane", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of enflurane.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "halothane", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of halothane.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "ribostamycin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "decamethonium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "barnidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of barnidipine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "ribostamycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of ribostamycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "methoxyflurane", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of methoxyflurane.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "metrizamide", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of metrizamide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "DESFLURANE", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of DESFLURANE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Risedronic acid", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Risedronic acid.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "polymyxin b", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "polymyxin b may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "gentamicin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of gentamicin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "PERHEXILINE", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of PERHEXILINE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Clevidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Clevidipine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nilvadipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nilvadipine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "doxorubicin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Arbekacin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Arbekacin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "decamethonium", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Colistimethate", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Colistimethate may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "lincomycin", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of lincomycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "gentamicin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "gentamicin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "felodipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of felodipine.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "streptozocin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of streptozocin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "isoflurane", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of isoflurane.", "severity": 2}
{"drug1": "paromomycin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "paromomycin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "PERHEXILINE", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of PERHEXILINE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Risedronic acid", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Risedronic acid.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "eperisone", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of eperisone.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Spectinomycin may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Lercanidipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Lercanidipine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "minocycline", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of minocycline.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "pancuronium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "bepridil", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of bepridil.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "capreomycin", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of capreomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nicardipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nicardipine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "piperacillin", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of piperacillin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "enflurane", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of enflurane.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "chlortetracycline", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of chlortetracycline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "pancuronium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "polymyxin b", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of polymyxin b.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "tolfenamic acid", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of tolfenamic acid.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "cyclosporin A", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of cyclosporin A.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "Rocuronium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "spironolactone", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of spironolactone.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "flunarizine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of flunarizine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "doxorubicin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of doxorubicin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "tubocurarine may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Clevidipine", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of Clevidipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "doxycycline", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of doxycycline.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "quinidine", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of quinidine.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "demeclocycline", "interaction_type": 21, "interaction_text": "METOCURINE may increase the neuromuscular blocking activities of demeclocycline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "amikacin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of amikacin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "flunarizine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of flunarizine.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "Cisatracurium may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Arbekacin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of Arbekacin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "cinnarizine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of cinnarizine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Magnesium salicylate", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nimesulide", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of nimesulide.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "PYRANTEL may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "dantrolene", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of dantrolene.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nisoldipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nisoldipine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "Vecuronium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "kanamycin", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of kanamycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Colistimethate", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of Colistimethate.", "severity": 2}
{"drug1": "decamethonium", "drug2": "lithium ion", "interaction_type": 21, "interaction_text": "decamethonium may increase the neuromuscular blocking activities of lithium ion.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "IDARUBICIN", "interaction_type": 21, "interaction_text": "mecamylamine may increase the neuromuscular blocking activities of IDARUBICIN.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 21, "interaction_text": "PIPECURONIUM may increase the neuromuscular blocking activities of MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "nifedipine", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of nifedipine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "clindamycin", "interaction_type": 21, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the neuromuscular blocking activities of clindamycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "VERAPAMIL", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of VERAPAMIL.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Quinine", "interaction_type": 21, "interaction_text": "succinylcholine may increase the neuromuscular blocking activities of Quinine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "PROCAINAMIDE", "interaction_type": 21, "interaction_text": "Atracurium besylate may increase the neuromuscular blocking activities of PROCAINAMIDE.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "VANCOMYCIN", "interaction_type": 21, "interaction_text": "Doxacurium may increase the neuromuscular blocking activities of VANCOMYCIN.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "tolfenamic acid", "interaction_type": 21, "interaction_text": "Mivacurium may increase the neuromuscular blocking activities of tolfenamic acid.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Fluticasone furoate may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Dehydroepiandrosterone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "diflorasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "flumethasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "desoximetasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Mometasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "CLOBETASOL PROPIONATE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "estrone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "estrone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "difluprednate may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "prednisone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "prednisone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Fluprednidene may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "diflorasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "dexamethasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Tixocortol may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "FLUTICASONE PROPIONATE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "fluocinonide may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Ciclesonide may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "CORTISONE ACETATE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "FLUTICASONE PROPIONATE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "alclometasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "fludrocortisone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "flunisolide may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "difluprednate may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "triamcinolone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "paramethasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "PREDNICARBATE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Tixocortol may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "RIMEXOLONE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Fluprednidene may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "betamethasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "DEFLAZACORT may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "alclometasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "DESONIDE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "CORTISONE ACETATE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "amcinonide may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "triamcinolone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Estrone sulfate may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "methylprednisolone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "equilin", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "equilin may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "fludrocortisone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Halobetasol may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "flunisolide may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "loteprednol may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "halcinonide may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "formestane", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "formestane may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "FLUOCORTOLONE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "estrone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "estrone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "flurandrenolide may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "budesonide", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "budesonide may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "flurandrenolide may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "methylprednisolone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "RIMEXOLONE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "amcinonide may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "prednisone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "prednisone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "CLOBETASOL PROPIONATE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "medrysone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "medrysone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "paramethasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Ciclesonide may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "fluocinonide may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "loteprednol may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Estrone sulfate may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "DEFLAZACORT may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "CLOCORTOLONE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "hydrocortisone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "PREDNICARBATE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Fluticasone furoate may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "DESONIDE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "betamethasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Dehydroepiandrosterone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "medrysone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "medrysone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "FLUOCORTOLONE may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "flumethasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "formestane", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "formestane may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Clobetasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "CLOCORTOLONE may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "desoximetasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "budesonide", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "budesonide may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "hydrocortisone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "dexamethasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "halcinonide may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "equilin", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "equilin may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Atracurium besylate", "interaction_type": 22, "interaction_text": "Mometasone may increase the adverse neuromuscular activities of Atracurium besylate.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Halobetasol may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Mivacurium", "interaction_type": 22, "interaction_text": "Clobetasone may increase the adverse neuromuscular activities of Mivacurium.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "nortriptyline", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of nortriptyline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "amoxapine", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of amoxapine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "desipramine", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of desipramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "cyclobenzaprine", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of cyclobenzaprine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Tianeptine", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of Tianeptine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "imipramine", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of imipramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "clomipramine", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of clomipramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "amoxapine", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of amoxapine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "nortriptyline", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of nortriptyline.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "amoxapine", "interaction_type": 23, "interaction_text": "dextroamphetamine may increase the stimulatory activities of amoxapine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "nortriptyline", "interaction_type": 23, "interaction_text": "dextroamphetamine may increase the stimulatory activities of nortriptyline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "amitriptyline", "interaction_type": 23, "interaction_text": "AMPHETAMINE may increase the stimulatory activities of amitriptyline.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "trimipramine", "interaction_type": 23, "interaction_text": "dextroamphetamine may increase the stimulatory activities of trimipramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "imipramine", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of imipramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "amitriptyline", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of amitriptyline.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "amitriptyline", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of amitriptyline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "cyclobenzaprine", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of cyclobenzaprine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Tianeptine", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of Tianeptine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "trimipramine", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of trimipramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "protriptyline", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of protriptyline.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "trimipramine", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of trimipramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Dothiepin", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of Dothiepin.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "protriptyline", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of protriptyline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "amitriptyline", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of amitriptyline.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "protriptyline", "interaction_type": 23, "interaction_text": "dextroamphetamine may increase the stimulatory activities of protriptyline.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "nortriptyline", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of nortriptyline.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "amoxapine", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of amoxapine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nortriptyline", "interaction_type": 23, "interaction_text": "AMPHETAMINE may increase the stimulatory activities of nortriptyline.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "cyclobenzaprine", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of cyclobenzaprine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "protriptyline", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of protriptyline.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Tianeptine", "interaction_type": 23, "interaction_text": "dextroamphetamine may increase the stimulatory activities of Tianeptine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "amitriptyline", "interaction_type": 23, "interaction_text": "dextroamphetamine may increase the stimulatory activities of amitriptyline.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Dothiepin", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of Dothiepin.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "imipramine", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of imipramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "trimipramine", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of trimipramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "clomipramine", "interaction_type": 23, "interaction_text": "hydroxyamphetamine may increase the stimulatory activities of clomipramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "cyclobenzaprine", "interaction_type": 23, "interaction_text": "dextroamphetamine may increase the stimulatory activities of cyclobenzaprine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "amoxapine", "interaction_type": 23, "interaction_text": "AMPHETAMINE may increase the stimulatory activities of amoxapine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "clomipramine", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of clomipramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "trimipramine", "interaction_type": 23, "interaction_text": "AMPHETAMINE may increase the stimulatory activities of trimipramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Tianeptine", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of Tianeptine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Dothiepin", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of Dothiepin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "protriptyline", "interaction_type": 23, "interaction_text": "AMPHETAMINE may increase the stimulatory activities of protriptyline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "desipramine", "interaction_type": 23, "interaction_text": "Amfepramone may increase the stimulatory activities of desipramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "desipramine", "interaction_type": 23, "interaction_text": "Lisdexamfetamine may increase the stimulatory activities of desipramine.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "daunorubicin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of daunorubicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "kanamycin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of kanamycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "tobramycin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of tobramycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Valrubicin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of Valrubicin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "Amrubicin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of Amrubicin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "Zoledronic acid may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "Spectinomycin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of Spectinomycin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "Cis-mdp may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "gentamicin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of gentamicin.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "Epirubicin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of Epirubicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "Arbekacin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of Arbekacin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "metrizamide", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of metrizamide.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "PAMIDRONIC ACID may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "paromomycin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of paromomycin.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "netilmicin", "interaction_type": 24, "interaction_text": "Ibandronic Acid may increase the hypocalcemic activities of netilmicin.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "streptozocin", "interaction_type": 24, "interaction_text": "ALENDRONIC ACID may increase the hypocalcemic activities of streptozocin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "doxorubicin", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of doxorubicin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "amikacin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of amikacin.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "streptomycin", "interaction_type": 24, "interaction_text": "Clodronic Acid may increase the hypocalcemic activities of streptomycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "ribostamycin", "interaction_type": 24, "interaction_text": "Risedronic acid may increase the hypocalcemic activities of ribostamycin.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "plicamycin", "interaction_type": 24, "interaction_text": "Etidronic acid may increase the hypocalcemic activities of plicamycin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "IDARUBICIN", "interaction_type": 24, "interaction_text": "Tiludronic Acid may increase the hypocalcemic activities of IDARUBICIN.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "timolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "practolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "timolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "timolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "risperidone", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "risperidone may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "droxidopa", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "pergolide", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "timolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "practolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "clonidine", "drug2": "digitoxin", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of digitoxin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "clonidine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "practolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "timolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "risperidone", "drug2": "practolol", "interaction_type": 25, "interaction_text": "risperidone may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "risperidone may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "acetyldigitoxin", "interaction_type": 25, "interaction_text": "VERAPAMIL may increase the atrioventricular blocking (AV block) activities of acetyldigitoxin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "practolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "practolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "timolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ouabain", "interaction_type": 25, "interaction_text": "VERAPAMIL may increase the atrioventricular blocking (AV block) activities of ouabain.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "practolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "practolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "pergolide", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Dronedarone", "interaction_type": 25, "interaction_text": "VERAPAMIL may increase the atrioventricular blocking (AV block) activities of Dronedarone.", "severity": 2}
{"drug1": "pergolide", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "nicotine", "drug2": "adenosine", "interaction_type": 25, "interaction_text": "nicotine may increase the atrioventricular blocking (AV block) activities of adenosine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "deslanoside", "interaction_type": 25, "interaction_text": "VERAPAMIL may increase the atrioventricular blocking (AV block) activities of deslanoside.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "practolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "brimonidine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "naphazoline", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "ouabain", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of ouabain.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "deslanoside", "interaction_type": 25, "interaction_text": "edrophonium may increase the atrioventricular blocking (AV block) activities of deslanoside.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Dronedarone", "interaction_type": 25, "interaction_text": "diltiazem may increase the atrioventricular blocking (AV block) activities of Dronedarone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "ouabain", "interaction_type": 25, "interaction_text": "edrophonium may increase the atrioventricular blocking (AV block) activities of ouabain.", "severity": 2}
{"drug1": "epinephrine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "risperidone", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "risperidone may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "risperidone", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "risperidone may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "naphazoline", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "naphazoline", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "timolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "timolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "practolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "practolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "tizanidine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "pergolide", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "acetyldigitoxin", "interaction_type": 25, "interaction_text": "diltiazem may increase the atrioventricular blocking (AV block) activities of acetyldigitoxin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ouabain", "interaction_type": 25, "interaction_text": "diltiazem may increase the atrioventricular blocking (AV block) activities of ouabain.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "brimonidine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "droxidopa", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "VERAPAMIL", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of VERAPAMIL.", "severity": 2}
{"drug1": "droxidopa", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "epinephrine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "timolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "acetyldigitoxin", "interaction_type": 25, "interaction_text": "edrophonium may increase the atrioventricular blocking (AV block) activities of acetyldigitoxin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "practolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "practolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "timolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "droxidopa", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "risperidone", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "risperidone may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "Dronedarone", "interaction_type": 25, "interaction_text": "digoxin may increase the atrioventricular blocking (AV block) activities of Dronedarone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "deslanoside", "interaction_type": 25, "interaction_text": "diltiazem may increase the atrioventricular blocking (AV block) activities of deslanoside.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "practolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "brimonidine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "brimonidine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "timolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "practolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "practolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "practolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "timolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "deslanoside", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of deslanoside.", "severity": 2}
{"drug1": "guanabenz", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "brimonidine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "digitoxin", "interaction_type": 25, "interaction_text": "edrophonium may increase the atrioventricular blocking (AV block) activities of digitoxin.", "severity": 2}
{"drug1": "guanabenz", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "naphazoline", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "acetyldigitoxin", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of acetyldigitoxin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "epinephrine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "apomorphine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "droxidopa", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "practolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Bevantolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of Bevantolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "tizanidine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "timolol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "pergolide may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "digoxin", "interaction_type": 25, "interaction_text": "edrophonium may increase the atrioventricular blocking (AV block) activities of digoxin.", "severity": 2}
{"drug1": "droxidopa", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "epinephrine", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "bromocriptine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "acebutolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of acebutolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "BOPINDOLOL", "interaction_type": 25, "interaction_text": "Paliperidone may increase the atrioventricular blocking (AV block) activities of BOPINDOLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "diltiazem", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of diltiazem.", "severity": 2}
{"drug1": "clonidine", "drug2": "metoprolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of metoprolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "timolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "levonordefrin may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "tizanidine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Nebivolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of Nebivolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "timolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "Lofexidine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "naphazoline", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "Bethanidine may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "betaxolol", "interaction_type": 25, "interaction_text": "DEXMEDETOMIDINE may increase the atrioventricular blocking (AV block) activities of betaxolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "practolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of practolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "BISOPROLOL", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of BISOPROLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "GUANFACINE may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "propranolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of propranolol.", "severity": 2}
{"drug1": "naphazoline", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "naphazoline may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "celiprolol", "interaction_type": 25, "interaction_text": "ERGOTAMINE may increase the atrioventricular blocking (AV block) activities of celiprolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "benzphetamine may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Arotinolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of Arotinolol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "brimonidine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "timolol", "interaction_type": 25, "interaction_text": "METHAMPHETAMINE may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "sotalol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of sotalol.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "timolol", "interaction_type": 25, "interaction_text": "dipivefrin may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "ESMOLOL", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of ESMOLOL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "BUPRANOLOL", "interaction_type": 25, "interaction_text": "ropinirole may increase the atrioventricular blocking (AV block) activities of BUPRANOLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "xylometazoline may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "carvedilol", "interaction_type": 25, "interaction_text": "oxymetazoline may increase the atrioventricular blocking (AV block) activities of carvedilol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "alprenolol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of alprenolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "labetalol", "interaction_type": 25, "interaction_text": "MOXONIDINE may increase the atrioventricular blocking (AV block) activities of labetalol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "guanabenz may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "CARTEOLOL", "interaction_type": 25, "interaction_text": "droxidopa may increase the atrioventricular blocking (AV block) activities of CARTEOLOL.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "timolol", "interaction_type": 25, "interaction_text": "dihydroergotamine may increase the atrioventricular blocking (AV block) activities of timolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "digoxin", "interaction_type": 25, "interaction_text": "clonidine may increase the atrioventricular blocking (AV block) activities of digoxin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "nadolol", "interaction_type": 25, "interaction_text": "norepinephrine may increase the atrioventricular blocking (AV block) activities of nadolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "penbutolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of penbutolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "Etomidate may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "oxprenolol", "interaction_type": 25, "interaction_text": "PSEUDOEPHEDRINE may increase the atrioventricular blocking (AV block) activities of oxprenolol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "atenolol", "interaction_type": 25, "interaction_text": "epinephrine may increase the atrioventricular blocking (AV block) activities of atenolol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Prasugrel", "interaction_type": 26, "interaction_text": "Rifampicin may decrease the antiplatelet activities of Prasugrel.", "severity": 2}
{"drug1": "omeprazole", "drug2": "clopidogrel", "interaction_type": 26, "interaction_text": "omeprazole may decrease the antiplatelet activities of clopidogrel.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "clopidogrel", "interaction_type": 26, "interaction_text": "Cangrelor may decrease the antiplatelet activities of clopidogrel.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "clopidogrel", "interaction_type": 26, "interaction_text": "Esomeprazole may decrease the antiplatelet activities of clopidogrel.", "severity": 2}
{"drug1": "erythromycin", "drug2": "clopidogrel", "interaction_type": 26, "interaction_text": "erythromycin may decrease the antiplatelet activities of clopidogrel.", "severity": 2}
{"drug1": "morphine", "drug2": "clopidogrel", "interaction_type": 26, "interaction_text": "morphine may decrease the antiplatelet activities of clopidogrel.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "Prasugrel", "interaction_type": 26, "interaction_text": "Cangrelor may decrease the antiplatelet activities of Prasugrel.", "severity": 2}
{"drug1": "fenbufen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "nefazodone may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "suprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "diflunisal", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "antipyrine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "amitriptyline may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "cyclobenzaprine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "protriptyline may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "diflunisal", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "floctafenine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "nimesulide", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ketorolac", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "resveratrol", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "furazolidone", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of furazolidone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Salsalate", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "selegiline", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of selegiline.", "severity": 2}
{"drug1": "Icatibant", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "etodolac", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "acemetacin", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "aspirin", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Salsalate", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "diclofenac", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "fluoxetine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Toloxatone", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of Toloxatone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Pirlindole", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of Pirlindole.", "severity": 2}
{"drug1": "Icatibant", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "duloxetine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "diclofenac", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "suprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Droxicam", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "nimesulide", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "diflunisal", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "alclofenac", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "resveratrol", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "amoxapine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "doxepin may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "resveratrol", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "nabumetone", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Naftifine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "fluvoxamine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "aspirin", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "mirtazapine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "alclofenac", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "diflunisal", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "diflunisal", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "clomipramine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "Levomilnacipran may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "leflunomide", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "leflunomide", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "epirizole", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "ketorolac", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Apremilast", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "methylene blue", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of methylene blue.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "suprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "antipyrine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "floctafenine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "Escitalopram may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "nortriptyline may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "Tianeptine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "isocarboxazid", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of isocarboxazid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "resveratrol", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Tramadol", "drug2": "tranylcypromine", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of tranylcypromine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "suprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "trimipramine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Tramadol", "drug2": "moclobemide", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of moclobemide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "desipramine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "desipramine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "floctafenine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "azelastine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "epirizole", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "Milnacipran may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Phenelzine", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of Phenelzine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "AMPHETAMINE", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of AMPHETAMINE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "paroxetine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Apremilast may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "suprofen", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "etodolac", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "tolmetin", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "salicylamide", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "fenbufen", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "rasagiline", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of rasagiline.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "nabumetone", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "nabumetone may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "floctafenine", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "mycophenolate mofetil may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "imipramine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "imipramine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "oxyphenbutazone may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "salicylic acid may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Teriflunomide may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "tiaprofenic acid may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "chloroquine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "carprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "sulindac", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Droxicam may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "flurbiprofen may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "ZILEUTON may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Naftifine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "azelastine may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "resveratrol", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "celecoxib may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Salsalate may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "leflunomide may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Aceclofenac may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "tolmetin may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "diflunisal may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Icatibant may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Propacetamol may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "citalopram", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "citalopram may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "ibuprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "Olopatadine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "mesalamine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "meclofenamic acid may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "Olsalazine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "ketoprofen may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "resveratrol may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "Dothiepin may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "suprofen may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "tenoxicam may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "ETOFENAMATE may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "ketorolac may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Lornoxicam may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "indomethacin may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "mefenamic acid may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "tolfenamic acid may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "nimesulide", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "nimesulide may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "diclofenac", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "diclofenac may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "BENZYDAMINE may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "CLONIXIN may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "acemetacin may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "procarbazine", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of procarbazine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "sulfasalazine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Lumiracoxib may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "Nepafenac may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "aspirin may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "NAPROXEN may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "fenbufen", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "fenbufen may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "zaltoprofen may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "sertraline", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "sertraline may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Tramadol", "interaction_type": 27, "interaction_text": "venlafaxine may increase the neuroexcitatory activities of Tramadol.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "BALSALAZIDE may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "enoxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of enoxacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "ADAPALENE may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Pefloxacin", "interaction_type": 27, "interaction_text": "Pimecrolimus may increase the neuroexcitatory activities of Pefloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "sulindac may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "antipyrine may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "SERATRODAST may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "PIRFENIDONE may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Gatifloxacin", "interaction_type": 27, "interaction_text": "mesalamine may increase the neuroexcitatory activities of Gatifloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "alclofenac may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "Choline magnesium trisalicylate may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "norfloxacin", "interaction_type": 27, "interaction_text": "floctafenine may increase the neuroexcitatory activities of norfloxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Gemifloxacin", "interaction_type": 27, "interaction_text": "oxaprozin may increase the neuroexcitatory activities of Gemifloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "fleroxacin", "interaction_type": 27, "interaction_text": "epirizole may increase the neuroexcitatory activities of fleroxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "sparfloxacin", "interaction_type": 27, "interaction_text": "niflumic acid may increase the neuroexcitatory activities of sparfloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Loxoprofen may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "nalidixic acid", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of nalidixic acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "LEVOFLOXACIN", "interaction_type": 27, "interaction_text": "Masoprocol may increase the neuroexcitatory activities of LEVOFLOXACIN.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ROSOXACIN", "interaction_type": 27, "interaction_text": "fenoprofen may increase the neuroexcitatory activities of ROSOXACIN.", "severity": 2}
{"drug1": "salicylamide", "drug2": "cinoxacin", "interaction_type": 27, "interaction_text": "salicylamide may increase the neuroexcitatory activities of cinoxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "pargyline", "interaction_type": 27, "interaction_text": "Tramadol may increase the neuroexcitatory activities of pargyline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "Etoricoxib may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Trovafloxacin", "interaction_type": 27, "interaction_text": "etodolac may increase the neuroexcitatory activities of Trovafloxacin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "lansoprazole", "interaction_type": 28, "interaction_text": "Imatinib may increase the dermatologic adverse activities of lansoprazole.", "severity": 2}
{"drug1": "thalidomide", "drug2": "dexamethasone", "interaction_type": 28, "interaction_text": "thalidomide may increase the dermatologic adverse activities of dexamethasone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "mycophenolic acid may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Lumiracoxib may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Apremilast may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "epirizole", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "epirizole may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "salicylic acid may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Salsalate may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nabumetone", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "nabumetone may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Magnesium salicylate may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "CLONIXIN may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "ibuprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "fenoprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "ketorolac may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "phenytoin may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Olopatadine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Loxoprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "BENZYDAMINE may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "salicylamide may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "chloroquine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "chloroquine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "nimesulide may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "ibuprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "ADAPALENE may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "ADAPALENE may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "antipyrine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Olsalazine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "suprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "suprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "carprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "carprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Icatibant may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "ketorolac may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "TROLAMINE SALICYLATE may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Teriflunomide may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "sulindac", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "sulindac may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "mefenamic acid may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "azelastine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "azelastine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "fenbufen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "fenbufen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "floctafenine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "suprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "suprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "salicylamide may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "sulindac", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "sulindac may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "SERATRODAST may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "zaltoprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "phenytoin may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "indomethacin may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "meclofenamic acid may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Choline magnesium trisalicylate may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "ZILEUTON may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "BENZYDAMINE may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Nepafenac may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Pimecrolimus may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "salicylamide may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "tenoxicam may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "antipyrine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "PIRFENIDONE may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "tolmetin may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "mycophenolate mofetil may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "tiaprofenic acid may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Masoprocol may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Magnesium salicylate may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Lornoxicam may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "epirizole", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "epirizole may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "mycophenolic acid may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "celecoxib may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "mesalamine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "mesalamine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "ZILEUTON may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "TROLAMINE SALICYLATE may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "tolfenamic acid may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "SERATRODAST may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "ketoprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Pimecrolimus may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Teriflunomide may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "mycophenolic acid may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "ibuprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ketorolac", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "ketorolac may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Olsalazine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "tolmetin may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Olsalazine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "nimesulide may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "BALSALAZIDE may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulindac", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "sulindac may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Aceclofenac may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "PIRFENIDONE may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Teriflunomide may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "niflumic acid may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "suprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "suprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "leflunomide may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "nimesulide may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Nepafenac may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "NAPROXEN may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "phenytoin may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Icatibant may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "ketoprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "BENZYDAMINE may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "fenoprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "NAPROXEN may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "flurbiprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "celecoxib may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "celecoxib may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Fosphenytoin may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Teriflunomide may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Magnesium salicylate may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "phenytoin may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "ETOFENAMATE may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Nepafenac may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "tenoxicam may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "etodolac", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "etodolac may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Salsalate may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "tolmetin may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "meclofenamic acid may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "SERATRODAST may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "NAPROXEN may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "diclofenac may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "nimesulide may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Icatibant may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Choline magnesium trisalicylate may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "diflunisal may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "tenoxicam may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "sulfasalazine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Loxoprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "mycophenolic acid may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "ibuprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "sulfasalazine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "ETOFENAMATE may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "nabumetone may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "resveratrol may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "azelastine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "azelastine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "tolfenamic acid may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "tiaprofenic acid may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Etoricoxib may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "ZILEUTON may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "mycophenolate mofetil may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "TROLAMINE SALICYLATE may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "indomethacin may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Aceclofenac may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "diclofenac may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Choline magnesium trisalicylate may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "etodolac", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "etodolac may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "ZILEUTON may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Droxicam", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Droxicam may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Apremilast may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Loxoprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "ETOFENAMATE may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "oxyphenbutazone may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "carprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "carprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "resveratrol may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Loxoprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "epirizole", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "epirizole may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Naftifine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Naftifine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Lumiracoxib may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "alclofenac may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Droxicam", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Droxicam may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "aspirin", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "aspirin may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "niflumic acid may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "floctafenine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "leflunomide may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "nabumetone may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "leflunomide", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "leflunomide may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "oxaprozin may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "mesalamine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "mesalamine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "tolfenamic acid may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "fenoprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "ketoprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "diflunisal may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "chloroquine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "sulfasalazine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Lornoxicam may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "oxyphenbutazone may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Pimecrolimus may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "alclofenac may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Aceclofenac may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "oxaprozin may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "zaltoprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Olopatadine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Magnesium salicylate may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "flurbiprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "diclofenac may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "NAPROXEN may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "niflumic acid may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "BALSALAZIDE may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "oxyphenbutazone may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Nepafenac may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Propacetamol may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "tiaprofenic acid may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "oxyphenbutazone may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "resveratrol may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "zaltoprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "indomethacin", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "indomethacin may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "ADAPALENE may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "tolmetin may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Olopatadine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Etoricoxib may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Fosphenytoin may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "tolfenamic acid may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "mefenamic acid may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Fosphenytoin may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "PIRFENIDONE may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Droxicam", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Droxicam may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "aspirin", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "aspirin may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "salicylic acid may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "meclofenamic acid may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "diflunisal may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "oxaprozin may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "resveratrol may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Lumiracoxib may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Masoprocol may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Propacetamol may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "SERATRODAST may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "mesalamine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "salicylamide may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "TROLAMINE SALICYLATE may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "BENZYDAMINE may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "niflumic acid may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "mefenamic acid may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Olsalazine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "indomethacin may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "mesalamine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "mesalamine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "chloroquine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "chloroquine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "nabumetone may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "etodolac", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "etodolac may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "fenbufen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "fenbufen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "leflunomide may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Propacetamol may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Propacetamol may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "meclofenamic acid may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "suprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "suprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "zaltoprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "diflunisal may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Lornoxicam may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "ketoprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Lornoxicam may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Naftifine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Naftifine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "fenoprofen may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "epirizole", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "epirizole may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "flurbiprofen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "ADAPALENE may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Masoprocol may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Lumiracoxib may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "antipyrine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Aceclofenac may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Pimecrolimus may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "azelastine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "azelastine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Fosphenytoin may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Apremilast", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Apremilast may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "BALSALAZIDE may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Icatibant may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "tenoxicam may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "salicylic acid may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "PIRFENIDONE may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "salicylic acid may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Naftifine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "chloroquine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "etodolac", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "etodolac may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "floctafenine may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "ketorolac may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "antipyrine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Etoricoxib may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "tiaprofenic acid may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "azelastine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "azelastine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "mycophenolate mofetil may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "BALSALAZIDE may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Etoricoxib may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "sulfasalazine may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "flurbiprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Olopatadine may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Salsalate may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "oxaprozin may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "mefenamic acid may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "celecoxib may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "CLONIXIN may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "carprofen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "carprofen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulindac", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "sulindac may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "carprofen", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "carprofen may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "CLONIXIN may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "fenbufen", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "fenbufen may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "alclofenac", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "alclofenac may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "diclofenac may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "ETOFENAMATE may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "fenbufen may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "Choline magnesium trisalicylate may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "aspirin", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "aspirin may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "CLONIXIN may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Salsalate", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "Salsalate may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "aspirin", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "aspirin may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Droxicam may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Torasemide", "interaction_type": 29, "interaction_text": "Apremilast may decrease the diuretic activities of Torasemide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "furosemide", "interaction_type": 29, "interaction_text": "floctafenine may decrease the diuretic activities of furosemide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ETHACRYNIC ACID", "interaction_type": 29, "interaction_text": "mycophenolate mofetil may decrease the diuretic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "alclofenac", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "alclofenac may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "bumetanide", "interaction_type": 29, "interaction_text": "Masoprocol may decrease the diuretic activities of bumetanide.", "severity": 2}
{"drug1": "practolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "propranolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "amiodarone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "propranolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "sotalol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "timolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Sacubitril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "REMIFENTANIL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "altretamine", "drug2": "moclobemide", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of moclobemide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "doxazosin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "TAMSULOSIN may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "apomorphine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "apomorphine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Telmisartan may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Carbetocin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "cilazapril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "cilazapril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "rasagiline", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "rasagiline may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Candesartan cilexetil may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "betaxolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "atenolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "BUPRANOLOL may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "thiopental", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "tranylcypromine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Bretylium", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Bretylium may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Metipranolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Riociguat may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "ethanol", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "labetalol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Tolcapone may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "alfuzosin", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "epoprostenol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nitroglycerin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "REMIFENTANIL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Lofexidine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "isoflurane may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Olmesartan may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "ISOSORBIDE MONONITRATE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Nitroprusside may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "timolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "chlorthalidone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Aliskiren may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "cilazapril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "cilazapril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "timolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "ILOPROST may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "BENDROFLUMETHIAZIDE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "thiamylal", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "D-mannitol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "NITROUS ACID may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "thalidomide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "thalidomide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "apraclonidine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ethanol", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "tretinoin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "ISOSORBIDE DINITRATE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "thiopental", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "methyclothiazide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "lisinopril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "mecamylamine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Clofarabine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Levobupivacaine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "diltiazem", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "diltiazem may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Clevidipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "celiprolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "sotalol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nimodipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "lisinopril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "secobarbital", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "felodipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "felodipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "propranolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "metoprolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "apomorphine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "indapamide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "indapamide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "primidone", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "morphine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "morphine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "BUPRANOLOL may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "halothane", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "halothane may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "labetalol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "minoxidil", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "minoxidil may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "labetalol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "dichlorphenamide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "enalapril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "enalapril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Eprosartan may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "SUFENTANIL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "AMILORIDE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "levodopa may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "felodipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "felodipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Lacidipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "isradipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "isradipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "nadolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nisoldipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "nadolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "triamterene", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "triamterene may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "selegiline", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of selegiline.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "isoxsuprine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "labetalol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "hydrochlorothiazide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "altretamine", "drug2": "protriptyline", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of protriptyline.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "dipyridamole may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "altretamine", "drug2": "furazolidone", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of furazolidone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "metoprolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "labetalol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "altretamine", "drug2": "pargyline", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of pargyline.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Enalaprilat may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "thiopental", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "nadolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "halothane", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "halothane may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "amifostine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "amifostine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "ISOSORBIDE MONONITRATE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "altretamine", "drug2": "trimipramine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of trimipramine.", "severity": 2}
{"drug1": "altretamine", "drug2": "doxepin", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of doxepin.", "severity": 2}
{"drug1": "ethanol", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "minoxidil", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "minoxidil may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "tizanidine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "celiprolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "thiopental", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "furosemide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "furosemide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "timolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "cilnidipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "practolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "sevoflurane may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nicardipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Canagliflozin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "nortriptyline", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of nortriptyline.", "severity": 2}
{"drug1": "valsartan", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "valsartan may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "altretamine", "drug2": "rasagiline", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "LEVOBUNOLOL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "phenoxybenzamine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "ISOSORBIDE DINITRATE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "diltiazem may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "altretamine", "drug2": "Pirlindole", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of Pirlindole.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "alfuzosin", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "altretamine", "drug2": "methylene blue", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of methylene blue.", "severity": 2}
{"drug1": "thiopental", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "hydralazine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "betaxolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "clozapine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "clozapine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "morphine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "morphine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "LEVOBUNOLOL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "chlorthalidone may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "timolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "GUANFACINE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "ethanol", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "celiprolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "labetalol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "primidone", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "primidone", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "amphotericin b may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "atenolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "atenolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "terazosin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "terazosin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "primidone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "LEVOSIMENDAN may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "nadolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nilvadipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "arsenic trioxide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Pentyl nitrite may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "amiodarone may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "nadolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "acebutolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Ropivacaine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "acebutolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "hydrochlorothiazide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "isoxsuprine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "acebutolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nifedipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Levobupivacaine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Eplerenone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "GUANFACINE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "carvedilol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "carvedilol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "amoxapine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of amoxapine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Conivaptan may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "metoprolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "altretamine", "drug2": "Phenelzine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Bortezomib may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Conivaptan may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "bepridil", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "bepridil may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "nadolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "furosemide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "furosemide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "arsenic trioxide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "bupivacaine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "bromocriptine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Carbetocin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "ETHACRYNIC ACID may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "bepridil", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "bepridil may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Bretylium may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Rotigotine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "imipramine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "imipramine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Lercanidipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "thioridazine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Tolcapone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Lofexidine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "methyldopa may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "BUPRANOLOL may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "ethanol", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Torasemide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "bumetanide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ethanol", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "thiopental", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Enalaprilat may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "metoprolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "metoprolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "fenoldopam may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "timolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "altretamine", "drug2": "isocarboxazid", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "altretamine", "drug2": "clomipramine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of clomipramine.", "severity": 2}
{"drug1": "atenolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "captopril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "captopril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "methyclothiazide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "DEXMEDETOMIDINE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "celiprolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "fosinopril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "ILOPROST may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "MOEXIPRIL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nilvadipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "amobarbital", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "ethanol", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "ethanol", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "clonidine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "clonidine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "NITROUS ACID may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nimodipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "tolazoline", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "tolazoline may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "primidone", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "nifedipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nifedipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "amobarbital", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "thiopental", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "apraclonidine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "altretamine", "drug2": "mirtazapine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of mirtazapine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "hydroflumethiazide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "quetiapine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "spironolactone", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "spironolactone may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "metolazone", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "metolazone may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "amobarbital", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "practolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "thiopental", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "practolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "trandolapril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "irbesartan", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "irbesartan may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "isoflurane may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "pramipexole", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "pramipexole may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "tranylcypromine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of tranylcypromine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nitrendipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Clofarabine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "fenoldopam may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "enalapril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "enalapril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "phentolamine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "phentolamine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "MOXONIDINE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "primidone", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "AMILORIDE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "MOXONIDINE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Empagliflozin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "nadolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "primidone", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "sotalol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "atenolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Pipamperone may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Aliskiren may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "sevoflurane may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "secobarbital", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Torasemide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "propofol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "propofol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "irbesartan", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "irbesartan may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "losartan", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "losartan may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "clomipramine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "clomipramine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "DEXMEDETOMIDINE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nitrendipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "metoprolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "alprenolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "primidone", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "alprenolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "alprenolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "sotalol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nicardipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Dapagliflozin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "Toloxatone", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of Toloxatone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "QUINETHAZONE", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of QUINETHAZONE.", "severity": 2}
{"drug1": "propranolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "ethanol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "SUFENTANIL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "VERAPAMIL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "sotalol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "nadolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "altretamine", "drug2": "desipramine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of desipramine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "practolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "D-mannitol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "PERINDOPRIL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "BENDROFLUMETHIAZIDE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "thiopental", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "spironolactone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "polythiazide", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Pentyl nitrite may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "carvedilol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "alprenolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "metolazone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "metolazone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "alprenolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "propranolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Lacidipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ethanol", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "hydrochlorothiazide", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "TAMSULOSIN may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "amphotericin b may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "metoprolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Lercanidipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "timolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "amobarbital", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "BUPRANOLOL may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "BUPRANOLOL may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Phenelzine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "BUPRANOLOL may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "atenolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "DESFLURANE may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "acebutolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "dipyridamole may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "Tianeptine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of Tianeptine.", "severity": 2}
{"drug1": "altretamine", "drug2": "Dothiepin", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of Dothiepin.", "severity": 2}
{"drug1": "valsartan", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "valsartan may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Metipranolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "carvedilol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "carvedilol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "sotalol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "phentolamine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "timolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "tizanidine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "PERINDOPRIL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Efonidipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nitric oxide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nitroglycerin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "epoprostenol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Ropivacaine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Candesartan cilexetil may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Olmesartan may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "practolol", "drug2": "alfuzosin", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "bromocriptine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "methazolamide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "altretamine", "drug2": "AMPHETAMINE", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "terazosin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "terazosin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "procarbazine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of procarbazine.", "severity": 2}
{"drug1": "reserpine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "reserpine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "selegiline", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "selegiline may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "sotalol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "ETHACRYNIC ACID may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "isradipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "isradipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "thalidomide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "penbutolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "thiamylal may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Clevidipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "BUPRANOLOL may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "quetiapine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "quetiapine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "dichlorphenamide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "thioridazine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "thioridazine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "hydroflumethiazide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "tretinoin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "tretinoin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "ramipril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "ramipril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "propranolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "alfuzosin", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Dapagliflozin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "sotalol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "prazosin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "prazosin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "benazepril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "benazepril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Canagliflozin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "MOEXIPRIL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "secobarbital", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "benazepril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "benazepril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "acebutolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "CARTEOLOL may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Pipamperone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "trichlormethiazide", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "alprenolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "alprenolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "fosinopril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "quinapril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "quinapril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "captopril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "captopril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Eprosartan may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "clonidine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "clonidine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "amobarbital", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "amobarbital may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "ropinirole may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nitric oxide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "barnidipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "secobarbital may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "losartan", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "losartan may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "brimonidine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "carvedilol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "carvedilol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "triamterene", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "triamterene may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "ramipril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "ramipril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "practolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "prazosin", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "prazosin may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "DESFLURANE may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "ethanol", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "ethanol may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "alprenolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "alprenolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "atenolol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "tolazoline may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "phenoxybenzamine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "alprenolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "alprenolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Nabilone may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Empagliflozin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "methyldopa may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "propranolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "betaxolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "Arotinolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "labetalol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "papaverine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "papaverine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "nisoldipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Nitroprusside may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Efonidipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "thiopental", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "methazolamide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "methazolamide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "Bevantolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "propranolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "propranolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "labetalol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "labetalol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "amifostine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "amifostine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Bortezomib may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "doxazosin", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "doxazosin may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Sacubitril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "barnidipine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "barnidipine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "cilnidipine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Riociguat", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Riociguat may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "atenolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "atenolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "brimonidine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "brimonidine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "practolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "practolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "bupivacaine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "timolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "timolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "alfuzosin", "interaction_type": 30, "interaction_text": "ESMOLOL may increase the orthostatic hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "indapamide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "indapamide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "primidone", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "thiopental", "drug2": "metolazone", "interaction_type": 30, "interaction_text": "thiopental may increase the orthostatic hypotensive activities of metolazone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "chlorothiazide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "altretamine", "drug2": "cyclobenzaprine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "METHOHEXITAL may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "Eplerenone may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "mecamylamine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "Telmisartan may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "primidone", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "primidone may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "methyclothiazide", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "hydralazine may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "propofol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "propofol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "penbutolol may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "altretamine", "drug2": "amitriptyline", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of amitriptyline.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "hydroflumethiazide", "interaction_type": 30, "interaction_text": "Mephobarbital may increase the orthostatic hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chlorthalidone", "interaction_type": 30, "interaction_text": "pentobarbital may increase the orthostatic hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "reserpine may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "TAMSULOSIN", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "quinapril", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "quinapril may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Silodosin", "interaction_type": 30, "interaction_text": "acebutolol may increase the orthostatic hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "nadolol", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "nadolol may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "BISOPROLOL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "bumetanide", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "bumetanide may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "carvedilol", "interaction_type": 30, "interaction_text": "BOPINDOLOL may increase the orthostatic hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "isocarboxazid may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "altretamine", "drug2": "imipramine", "interaction_type": 30, "interaction_text": "altretamine may increase the orthostatic hypotensive activities of imipramine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "levodopa", "interaction_type": 30, "interaction_text": "VERAPAMIL may increase the orthostatic hypotensive activities of levodopa.", "severity": 2}
{"drug1": "trandolapril", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "trandolapril may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlorothiazide", "interaction_type": 30, "interaction_text": "phenobarbital may increase the orthostatic hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "Nebivolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "indapamide", "interaction_type": 30, "interaction_text": "Hexobarbital may increase the orthostatic hypotensive activities of indapamide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "chlorothiazide may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "celiprolol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "carvedilol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "LEVOSIMENDAN may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "labetalol", "interaction_type": 30, "interaction_text": "celiprolol may increase the orthostatic hypotensive activities of labetalol.", "severity": 2}
{"drug1": "sotalol", "drug2": "duloxetine", "interaction_type": 30, "interaction_text": "sotalol may increase the orthostatic hypotensive activities of duloxetine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "prazosin", "interaction_type": 30, "interaction_text": "carvedilol may increase the orthostatic hypotensive activities of prazosin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "terazosin", "interaction_type": 30, "interaction_text": "oxprenolol may increase the orthostatic hypotensive activities of terazosin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "doxazosin", "interaction_type": 30, "interaction_text": "celiprolol may increase the orthostatic hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "methylene blue", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when methylene blue is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Toloxatone", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when Toloxatone is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Pirlindole", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when Pirlindole is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "tranylcypromine", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when tranylcypromine is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "selegiline", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when selegiline is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "pargyline", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when pargyline is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "furazolidone", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when furazolidone is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "moclobemide", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when moclobemide is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Phenelzine", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when Phenelzine is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "rasagiline", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when rasagiline is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "AMPHETAMINE", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when AMPHETAMINE is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "procarbazine", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when procarbazine is combined with methyldopa.", "severity": 2}
{"drug1": "methyldopa", "drug2": "isocarboxazid", "interaction_type": 31, "interaction_text": "The risk or severity of hypertension can be increased when isocarboxazid is combined with methyldopa.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "VALPROIC ACID may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "baclofen", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "baclofen may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Dexbrompheniramine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "topiramate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "topiramate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "clidinium", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "clidinium may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Lormetazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "DIHYDROCODEINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Eszopiclone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Tolcapone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "DESFLURANE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "CHLOROPROCAINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "HYDROCODONE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "MOLINDONE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "thiamylal may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "quetiapine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "quetiapine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "fludiazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Dexbrompheniramine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "amitriptyline may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "trazodone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "trazodone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "midazolam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "oxprenolol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "halothane", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "halothane may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Ziprasidone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Lormetazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ethosuximide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Methadyl acetate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "thioridazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "thioridazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "oxprenolol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "flurazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "flunarizine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Hexobarbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Perospirone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "imipramine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "GUANFACINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Lormetazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "clozapine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "clozapine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "KETAZOLAM may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Pipamperone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "METHOHEXITAL may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "clonazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "clonazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ondansetron may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "lithium ion may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "zonisamide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "carbamazepine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Butethal may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "desipramine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "desipramine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "FLUPHENAZINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Pipotiazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "prilocaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "clomipramine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Levobupivacaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Ropivacaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "butamben", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "butamben may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "efavirenz may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ethchlorvynol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Suvorexant may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "chloral hydrate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Etidocaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "brotizolam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Pramocaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "quetiapine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Zuclopenthixol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "ethanol", "interaction_type": 32, "interaction_text": "STIRIPENTOL may increase the sedative activities of ethanol.", "severity": 2}
{"drug1": "triprolidine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "triprolidine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "orphenadrine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "oxymorphone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "sulpiride", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "sulpiride may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Pipamperone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clidinium", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "clidinium may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zopiclone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "zopiclone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "alprazolam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "morphine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "morphine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "nitrazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "FLUPHENAZINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "nalbuphine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "bupivacaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Levetiracetam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "butorphanol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethanol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ethanol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "amobarbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "doxepin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "doxepin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "MOLINDONE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "vigabatrin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Articaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Articaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "clomipramine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "clomipramine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "cocaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "cocaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "amisulpride may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "dantrolene may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "promethazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "promethazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "promazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "promazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "nortriptyline may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Zuclopenthixol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Suvorexant may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "quetiapine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "pentobarbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "bupivacaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "hydromorphone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "clidinium", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "clidinium may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "pentazocine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Fencamfamin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "carbamazepine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "felbamate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "felbamate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Eszopiclone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Mephobarbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Olopatadine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Sodium oxybate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clozapine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "clozapine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "methoxyflurane may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Pomalidomide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "imipramine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "tizanidine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "chlorprothixene may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Oxybuprocaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "clozapine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "CHLOROPROCAINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "zaleplon may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "meperidine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "meperidine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "butamben", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "butamben may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "chlordiazepoxide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "tizanidine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Levocetirizine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "benzyl alcohol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "olanzapine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Iloperidone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Pramocaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "oxazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "CYPROHEPTADINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "propofol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "propofol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Retigabine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "fludiazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Remoxipride may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Pipotiazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "thioridazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "quetiapine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "flunarizine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "pimozide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "pimozide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "MOLINDONE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "codeine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "codeine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "isoflurane may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "chlorpheniramine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Ziprasidone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Fospropofol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "promazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "promazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "nitrazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "cetirizine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "4-Hydroxybutanoic acid may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Articaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Articaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "brimonidine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "mirtazapine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Melatonin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Levetiracetam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "pentobarbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "methoxyflurane may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "meprobamate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "tizanidine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "proparacaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "proparacaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Methadyl acetate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Aceprometazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "DEZOCINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Retigabine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Retigabine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "thiothixene", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "thiothixene may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "PARALDEHYDE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "STIRIPENTOL may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "azelastine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "azelastine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "diphenhydramine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "estazolam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "carisoprodol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "BREXPIPRAZOLE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "olanzapine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "olanzapine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "loxapine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "meprobamate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "meprobamate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Perampanel", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Perampanel may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "isoflurane may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "SERTINDOLE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "levorphanol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Ethylmorphine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "SERTINDOLE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Pregabalin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Gabapentin enacarbil may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "meprobamate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "prochlorperazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "BREXPIPRAZOLE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "METHOHEXITAL may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "lorazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "prazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "prazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "lithium ion may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Levetiracetam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Iloperidone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "baclofen", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "baclofen may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "methoxyflurane may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "brimonidine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "oxycodone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "SUFENTANIL may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "clonidine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "clonidine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Lurasidone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Asenapine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "mesoridazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Halazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Halazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "GUANFACINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "thioridazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Gabapentin enacarbil may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "loxapine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "DEXMEDETOMIDINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "PARALDEHYDE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "amoxapine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "meclizine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "meclizine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "isoflurane may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Tasimelteon may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "dibucaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "dibucaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "DESFLURANE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "trimipramine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Fosphenytoin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "DIPHENOXYLATE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "pimozide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "pimozide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "nitrous oxide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clidinium", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "clidinium may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Perospirone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "chlormezanone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "topiramate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "topiramate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "procaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "procaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Gabapentin enacarbil may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "DEXMEDETOMIDINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "DIPHENOXYLATE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "methadone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "methadone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "SERTINDOLE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "primidone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "primidone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "vigabatrin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "METHOHEXITAL may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Normethadone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "lorazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ethosuximide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "tetracaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "fexofenadine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "fludiazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Etidocaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "DEXMEDETOMIDINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ethchlorvynol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "ethotoin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ethotoin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "diphenhydramine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "fexofenadine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "reserpine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "reserpine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Butethal", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Butethal may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Perampanel", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Perampanel may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "hydromorphone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "brotizolam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Flupentixol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "loratadine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "loratadine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "KETAZOLAM may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "METAXALONE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "bromazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "clorazepate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "4-Hydroxybutanoic acid may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "droperidol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "droperidol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "TETRABENAZINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "trimipramine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "chlordiazepoxide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "carbamazepine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Lurasidone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "METHSUXIMIDE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Halazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Tramadol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "estazolam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "thiamylal", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "thiamylal may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "gabapentin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "buspirone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "buspirone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "DEZOCINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "amoxapine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Propoxycaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "propofol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "propofol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "benzocaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "benzocaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "triazolam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Perampanel", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Perampanel may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "HYDROCODONE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "oxprenolol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "cetirizine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Flupentixol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "DESFLURANE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Nabilone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "midazolam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "midazolam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "enflurane", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "enflurane may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Tolcapone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "mirtazapine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "nitrazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "cetirizine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "cetirizine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "diazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "nitrazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "fluvoxamine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "diphenhydramine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "oxazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "FLUTICASONE PROPIONATE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "trimipramine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "trimipramine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ALFENTANIL may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "glutethimide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "glutethimide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "scopolamine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "dyclonine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "dyclonine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Dexbrompheniramine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "flurazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "clorazepate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "risperidone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "risperidone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Paliperidone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "brotizolam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "brotizolam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "clomipramine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "clonazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "lorazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Nabilone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "CYPROHEPTADINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "tranylcypromine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "prochlorperazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Articaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Articaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "VALPROIC ACID may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "levorphanol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "levorphanol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "quazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "quazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "mirtazapine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "trimipramine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "sulpiride may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Ketobemidone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "benzyl alcohol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "zonisamide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "SUFENTANIL may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "clonazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "clonazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "efavirenz may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Agomelatine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Pomalidomide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "CYCLIZINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Flupentixol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Tasimelteon may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "zolpidem may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Lurasidone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "MAGNESIUM SULFATE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Olopatadine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "flunarizine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "primidone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "primidone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Gabapentin enacarbil may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Lormetazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Fospropofol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ALFENTANIL may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "halothane", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "halothane may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "tranylcypromine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "gabapentin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "gabapentin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Etomidate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "hydroxyzine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "HEROIN", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "HEROIN may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "imipramine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "imipramine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "levorphanol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "etizolam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "etizolam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "fluvoxamine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "meclizine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "meclizine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "maprotiline", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "maprotiline may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "trazodone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "trazodone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ethyl loflazepate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "propoxyphene may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "risperidone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "risperidone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Oxybuprocaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "olanzapine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "glutethimide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "cyclobenzaprine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "oxazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "TRICHLOROETHYLENE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "4-Hydroxybutanoic acid may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "loxapine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Eszopiclone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "mepivacaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "CYPROHEPTADINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "orphenadrine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Pomalidomide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "doxepin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "doxepin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Articaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Articaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "flunitrazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "oxycodone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Sodium oxybate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "pimozide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Desloratadine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "amobarbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "haloperidol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Aripiprazole may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "tetracaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Normethadone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Normethadone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amobarbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "amobarbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "BREXPIPRAZOLE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "trifluoperazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "doxylamine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "doxylamine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "chlormezanone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "DEZOCINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Tapentadol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "dantrolene", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "dantrolene may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Lurasidone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "CYCLIZINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "HYDROCODONE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "thiopental may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "estazolam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "FLUTICASONE PROPIONATE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "perphenazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "lithium ion may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "triflupromazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "promazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "promazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "cyclobenzaprine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Tasimelteon may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Perampanel may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "DIMENHYDRINATE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "orphenadrine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Agomelatine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "FLUPHENAZINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "lidocaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Tapentadol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Ramelteon may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "procaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "procaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "chloral hydrate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "temazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "triflupromazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "CHLOROPROCAINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "tiapride", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "tiapride may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Oxetacaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ethyl loflazepate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "doxepin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "doxepin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "butamben", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "butamben may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Oxybuprocaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "desipramine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "desipramine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "risperidone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "etizolam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "etizolam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "fluvoxamine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "bromazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "REMIFENTANIL may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "TRICHLOROETHYLENE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "flurazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clonidine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "clonidine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "cyclobenzaprine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "thiopental", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "thiopental may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "flunitrazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ethyl loflazepate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Iloperidone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ketamine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ketamine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "DIMENHYDRINATE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "methocarbamol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Ziprasidone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "pentazocine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "pentazocine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "estazolam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "TRICHLOROETHYLENE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "butorphanol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zolpidem", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "zolpidem may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "chlorzoxazone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Methadyl acetate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ethyl loflazepate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Retigabine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Retigabine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "doxylamine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "doxylamine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Tasimelteon may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "hydroxyzine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "methocarbamol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethotoin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ethotoin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "efavirenz", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "efavirenz may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "zonisamide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "zonisamide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "carisoprodol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "prilocaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "reserpine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "reserpine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "promazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "promazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "benzyl alcohol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "thiopental may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "scopolamine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "levodopa", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "levodopa may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "enflurane", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "enflurane may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "propofol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "propofol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "levodopa", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "levodopa may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "triprolidine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "nitrous oxide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Hexobarbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "alprazolam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "lorazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "felbamate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "felbamate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "cocaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "cocaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Zuclopenthixol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "TETRABENAZINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Melatonin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "doxylamine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "doxylamine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "dibucaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "REMIFENTANIL may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Ethylmorphine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "triazolam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "phenobarbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "butorphanol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "DIMENHYDRINATE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "cocaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "cocaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Aripiprazole may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Aceprometazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "trifluoperazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "PARALDEHYDE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "nitrous oxide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "pentobarbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "bromazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Fluspirilene may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Etomidate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "chlorpheniramine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "morphine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "morphine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ethosuximide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "halothane", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "halothane may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "carbamazepine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Eszopiclone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "codeine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "codeine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clozapine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "clozapine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "pentazocine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "VORTIOXETINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Levocetirizine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Levetiracetam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "baclofen", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "baclofen may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "procaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "procaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "butabarbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "haloperidol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "haloperidol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "METHOHEXITAL may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Tolcapone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "tetracaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "tetracaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "carisoprodol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "trazodone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "trazodone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "zopiclone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Oxetacaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "levorphanol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "propofol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "propofol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Tolcapone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "amoxapine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Flibanserin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Dexbrompheniramine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "MELPERONE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "PARALDEHYDE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "thioridazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "pentazocine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "pentazocine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "DIPHENOXYLATE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "butorphanol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "butorphanol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "chlorzoxazone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "mesoridazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "DESFLURANE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "baclofen", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "baclofen may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Ethylmorphine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "sevoflurane may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "CHLOROPROCAINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "thalidomide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "tranylcypromine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "MELPERONE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "triflupromazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "zolpidem may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Ziprasidone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "topiramate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "topiramate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "secobarbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Fosphenytoin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Levobupivacaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Aceprometazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Tapentadol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "buspirone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "phenobarbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "clorazepate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "tiapride", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "tiapride may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "loratadine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "loratadine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "nortriptyline may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "fludiazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "SUFENTANIL may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "oxycodone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "ketamine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ketamine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "protriptyline may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Ramelteon may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ondansetron may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Ethylmorphine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Ketobemidone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "thiamylal may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "buprenorphine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "orphenadrine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "tiagabine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "nortriptyline may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amisulpride", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "amisulpride may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethanol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ethanol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "propoxyphene may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Fosphenytoin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "SERTINDOLE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "triprolidine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "triprolidine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "meperidine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "amoxapine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "DIHYDROCODEINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Propoxycaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "reserpine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "reserpine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "secobarbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "alprazolam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "alprazolam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "nalbuphine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "butabarbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Levomepromazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "maprotiline", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "maprotiline may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "tiagabine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "fexofenadine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "DIHYDROCODEINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "lidocaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "buspirone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "doxylamine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "doxylamine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "haloperidol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Ramelteon may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "thalidomide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "perphenazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ketamine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "enflurane", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "enflurane may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Remoxipride may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Perospirone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "bupivacaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "flunarizine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "flunarizine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "HEROIN may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ALFENTANIL may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "DIHYDROCODEINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "MELPERONE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "prochlorperazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "promethazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "promethazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ethanol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "glutethimide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Nabilone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "loratadine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "loratadine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "thiamylal may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "quazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "quazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Pipamperone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "chlorzoxazone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "phenytoin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Fencamfamin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Agomelatine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "chlorprothixene may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "GUANFACINE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "chlorpheniramine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Pregabalin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ethchlorvynol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Sodium oxybate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "oxymorphone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "dantrolene may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Flibanserin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "buspirone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "buspirone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "trifluoperazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "zaleplon may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "dibucaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "isoflurane", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "isoflurane may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "sevoflurane may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "chloral hydrate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Pregabalin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Levobupivacaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ondansetron may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Pomalidomide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ethosuximide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "quazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "quazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "hydromorphone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "triprolidine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "triprolidine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "perphenazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "ethanol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ethanol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ALFENTANIL may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "chlordiazepoxide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "olanzapine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zopiclone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "zopiclone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "thiothixene may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Etidocaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "zopiclone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "reserpine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "reserpine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "etizolam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "etizolam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "midazolam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "midazolam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Melatonin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "butalbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "butalbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "scopolamine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "scopolamine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "quazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "quazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "VORTIOXETINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Etomidate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "secobarbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "REMIFENTANIL may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "butamben", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "butamben may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "nitrous oxide may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Asenapine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zotepine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "zotepine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clemastine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "clemastine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "diphenhydramine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "protriptyline", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "protriptyline may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "METAXALONE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "protriptyline may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "thalidomide may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "sevoflurane may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "chloral hydrate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "prochlorperazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "lithium ion may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Desloratadine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "meperidine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "meperidine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Aripiprazole may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Olopatadine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "HYDROCODONE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "perphenazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "perphenazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clemastine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "clemastine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Mephobarbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Etidocaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Mephobarbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "METHSUXIMIDE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Fosphenytoin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "hydroxyzine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "flunitrazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "STIRIPENTOL may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "buprenorphine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "VALPROIC ACID may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Asenapine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Fencamfamin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "FLUTICASONE PROPIONATE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "diazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "diazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "VORTIOXETINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "doxepin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "doxepin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Zuclopenthixol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "primidone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "primidone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Hexobarbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "zaleplon may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Flupentixol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "proparacaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Ketobemidone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "protriptyline", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "protriptyline may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Levomepromazine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Fluspirilene may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "zotepine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "zotepine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "desipramine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "desipramine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "phenytoin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "phenytoin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "meperidine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "DEZOCINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "etizolam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "etizolam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "amisulpride may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Pramocaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "dyclonine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "dyclonine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "BREXPIPRAZOLE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "propoxyphene may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "flunitrazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "levodopa", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "levodopa may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Suvorexant may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Halazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Halazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "felbamate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "felbamate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "mepivacaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "thalidomide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "methocarbamol may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "azelastine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "azelastine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "maprotiline may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "tetracaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "methadone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "methadone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "temazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "temazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "tiagabine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "tiagabine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "MELPERONE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "alprazolam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "amitriptyline may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "METAXALONE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Perospirone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "FLUTICASONE PROPIONATE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "oxymorphone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Fospropofol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "SUFENTANIL may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Tapentadol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "METHSUXIMIDE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Pregabalin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "KETAZOLAM may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "loxapine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "oxazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Levocetirizine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "desipramine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "desipramine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "chlormezanone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "butalbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "butalbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Fluspirilene may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "glutethimide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "glutethimide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "pimozide", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "pimozide may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "amitriptyline may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Suvorexant may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "ethotoin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Remoxipride may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "butalbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "butalbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "fexofenadine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Nabilone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Nabilone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "CYPROHEPTADINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "promethazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "promethazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "droperidol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "droperidol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "chlordiazepoxide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "METHSUXIMIDE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "REMIFENTANIL may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Levomepromazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Melatonin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "chlorprothixene may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "cetirizine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "prazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "prazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "benzocaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "DEXMEDETOMIDINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "azelastine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "azelastine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Sodium oxybate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "nalbuphine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "dyclonine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "dyclonine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "methoxyflurane may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "tranylcypromine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "meclizine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "meclizine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "CYCLIZINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "MAGNESIUM SULFATE may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "chlorzoxazone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "halothane", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "halothane may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Levocetirizine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "methadone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "methadone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "scopolamine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "scopolamine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Fluspirilene may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "midazolam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "loratadine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "loratadine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "mepivacaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "gabapentin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "gabapentin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Pramocaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "mesoridazine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "clomipramine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "tiapride", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "tiapride may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Olopatadine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Desloratadine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Oxetacaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Butethal", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Butethal may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "oxymorphone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Methadyl acetate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "chlorprothixene may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "DIPHENOXYLATE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "fluvoxamine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "prilocaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "prilocaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "TRICHLOROETHYLENE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "clorazepate may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Oxybuprocaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "secobarbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "chlormezanone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "clemastine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "clemastine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Ropivacaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "dyclonine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Pizotifen may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "meclizine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "meclizine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Pizotifen may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Hexobarbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "gabapentin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Paliperidone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "diazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "diazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "triazolam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "4-Hydroxybutanoic acid may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "VALPROIC ACID may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "KETAZOLAM may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "phenobarbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "morphine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "morphine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "proparacaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "proparacaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Aripiprazole may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "primidone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "primidone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "procaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "procaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "cyclobenzaprine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "nortriptyline may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "brimonidine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Pipotiazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "DIMENHYDRINATE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "dantrolene", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "dantrolene may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Remoxipride may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Propoxycaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Fospropofol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "HEROIN may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zotepine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "zotepine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "phenobarbital may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "phenytoin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "tiapride", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "tiapride may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Paliperidone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Oxetacaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "flurazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "benzocaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "zolpidem may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "temazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "temazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "levodopa", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "levodopa may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "MAGNESIUM SULFATE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "propoxyphene may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Pizotifen may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "prazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "prazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "bupivacaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "imipramine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "imipramine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Ramelteon may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Desloratadine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "thiopental may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "METAXALONE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "brimonidine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amobarbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "amobarbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "maprotiline may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Ketobemidone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ondansetron may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clonazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "clonazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "TETRABENAZINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Propoxycaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "felbamate", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "felbamate may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "vigabatrin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Difenoxin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "bromazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "prilocaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "prilocaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Difenoxin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Aceprometazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "clonidine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "clonidine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "risperidone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "risperidone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "buprenorphine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "brotizolam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "ketamine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "chlorpheniramine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Levobupivacaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "diazepam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "diazepam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "temazepam", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "temazepam may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "topiramate", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "topiramate may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Pizotifen may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Paliperidone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "azelastine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "azelastine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "clonidine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "CYCLIZINE may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "oxycodone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "amisulpride may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "proparacaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Halazepam", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Halazepam may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Butethal", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Butethal may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "lidocaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "morphine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "morphine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "phenytoin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "HEROIN", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "HEROIN may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "hydroxyzine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "butabarbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Etomidate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Etomidate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "amitriptyline may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "buprenorphine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "trifluoperazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "sevoflurane may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "pentobarbital may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "GUANFACINE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "hydromorphone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "MAGNESIUM SULFATE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "prazepam may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "triflupromazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "zotepine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "zotepine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "haloperidol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "methadone", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "methadone may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "dibucaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "dibucaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Difenoxin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Mephobarbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "benzyl alcohol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "meprobamate", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "meprobamate may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "ethotoin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "ethotoin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "MOLINDONE may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "droperidol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "droperidol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "ethchlorvynol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Agomelatine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "mesoridazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "butabarbital may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "thiothixene may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "efavirenz", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "efavirenz may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "methocarbamol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Fencamfamin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "zaleplon may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "mepivacaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Normethadone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "triazolam may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Normethadone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Normethadone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "thiothixene may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Flibanserin may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "enflurane", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "enflurane may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Pipamperone may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Tramadol may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "Retigabine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Retigabine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Asenapine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Asenapine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "zonisamide", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "zonisamide may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "Ropivacaine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "FLUPHENAZINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Iloperidone may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "VORTIOXETINE may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "trazodone", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "trazodone may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Difenoxin may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "carisoprodol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "vigabatrin may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Tramadol", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Tramadol may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "Pipotiazine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Flibanserin may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "tiagabine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "Levomepromazine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "oxprenolol may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "cocaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "cocaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "benzocaine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "benzocaine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "Ropivacaine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "butalbital", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "butalbital may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ropinirole", "interaction_type": 32, "interaction_text": "lidocaine may increase the sedative activities of ropinirole.", "severity": 2}
{"drug1": "clemastine", "drug2": "pramipexole", "interaction_type": 32, "interaction_text": "clemastine may increase the sedative activities of pramipexole.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Rotigotine", "interaction_type": 32, "interaction_text": "nalbuphine may increase the sedative activities of Rotigotine.", "severity": 2}
{"drug1": "codeine", "drug2": "METYROSINE", "interaction_type": 32, "interaction_text": "codeine may increase the sedative activities of METYROSINE.", "severity": 2}
{"drug1": "toremifene", "drug2": "cisapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with cisapride.", "severity": 4}
{"drug1": "disopyramide", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with arsenic trioxide.", "severity": 4}
{"drug1": "hydroxychloroquine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when hydroxychloroquine is combined with Artemether.", "severity": 4}
{"drug1": "domperidone", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when domperidone is combined with Iloperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "propofol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with propofol.", "severity": 4}
{"drug1": "cisapride", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Vandetanib.", "severity": 4}
{"drug1": "sotalol", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Flupentixol.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when fluoxetine is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Salbutamol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Salbutamol.", "severity": 4}
{"drug1": "sotalol", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Artemether.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "prochlorperazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with prochlorperazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "SULFADOXINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with SULFADOXINE.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Artemether.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with Vandetanib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Lumefantrine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Asenapine is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Quinine", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with Paliperidone.", "severity": 4}
{"drug1": "sotalol", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with quinidine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "REMIFENTANIL", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with REMIFENTANIL.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "tofisopam", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with tofisopam.", "severity": 4}
{"drug1": "pimozide", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pimozide is combined with Artemether.", "severity": 4}
{"drug1": "toremifene", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Lumefantrine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "pentazocine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with pentazocine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Flupentixol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "terbutaline", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with terbutaline.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "fleroxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with fleroxacin.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "L-tryptophan", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with L-tryptophan.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "astemizole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with astemizole.", "severity": 4}
{"drug1": "sotalol", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "sotalol", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Vandetanib.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "EFINACONAZOLE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with EFINACONAZOLE.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Escitalopram is combined with domperidone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "moclobemide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with moclobemide.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "toremifene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when fluoxetine is combined with toremifene.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Paliperidone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with sotalol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Pefloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Pefloxacin.", "severity": 4}
{"drug1": "toremifene", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Paliperidone.", "severity": 4}
{"drug1": "trimethoprim", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when trimethoprim is combined with Artemether.", "severity": 4}
{"drug1": "Halofantrine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Artemether.", "severity": 4}
{"drug1": "anagrelide", "drug2": "toremifene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with toremifene.", "severity": 4}
{"drug1": "cisapride", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with pimozide.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with sotalol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "viloxazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with viloxazine.", "severity": 4}
{"drug1": "sotalol", "drug2": "toremifene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with toremifene.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Asenapine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Paliperidone.", "severity": 4}
{"drug1": "quetiapine", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quetiapine is combined with Vandetanib.", "severity": 4}
{"drug1": "mefloquine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when mefloquine is combined with Artemether.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Flupentixol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "toremifene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with toremifene.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "HEROIN", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with HEROIN.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Lumefantrine.", "severity": 4}
{"drug1": "toremifene", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "cisapride", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Iloperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with quinidine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "toremifene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with toremifene.", "severity": 4}
{"drug1": "sotalol", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "nalidixic acid", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with nalidixic acid.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Asenapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Dronedarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Dronedarone.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Iloperidone.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when TETRABENAZINE is combined with Vandetanib.", "severity": 4}
{"drug1": "pimozide", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pimozide is combined with Lumefantrine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "droperidol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with droperidol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "PIRBUTEROL", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with PIRBUTEROL.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "sulconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with sulconazole.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Nilotinib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Nilotinib.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "lithium ion", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with lithium ion.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "domperidone", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when domperidone is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "triflupromazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with triflupromazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "flecainide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with flecainide.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Terlipressin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Terlipressin.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "norfloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with norfloxacin.", "severity": 4}
{"drug1": "Iloperidone", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Iloperidone is combined with Vandetanib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "toremifene", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with quinidine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Progabide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Progabide.", "severity": 4}
{"drug1": "citalopram", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when citalopram is combined with arsenic trioxide.", "severity": 4}
{"drug1": "anagrelide", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with domperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "roxithromycin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with roxithromycin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "ATOVAQUONE", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when ATOVAQUONE is combined with Artemether.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with pimozide.", "severity": 4}
{"drug1": "toremifene", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Halofantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Halofantrine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Cyamemazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Cyamemazine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Dronedarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with Dronedarone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Vandetanib.", "severity": 4}
{"drug1": "Zuclopenthixol", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Zuclopenthixol is combined with Vandetanib.", "severity": 4}
{"drug1": "toremifene", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Asenapine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "oxiconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with oxiconazole.", "severity": 4}
{"drug1": "disopyramide", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with Lumefantrine.", "severity": 4}
{"drug1": "toremifene", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with domperidone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "fluoxetine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with fluoxetine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Artemether.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Lopinavir", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Lopinavir.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Lumefantrine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "mesoridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with mesoridazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "DIPHENOXYLATE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with DIPHENOXYLATE.", "severity": 4}
{"drug1": "Artesunate", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Artesunate is combined with Artemether.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with sotalol.", "severity": 4}
{"drug1": "citalopram", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when citalopram is combined with sotalol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Ibutilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Ibutilide.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Flupentixol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Iloperidone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "fluoxetine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with fluoxetine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "tropisetron", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with tropisetron.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "pentamidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with pentamidine.", "severity": 4}
{"drug1": "thioridazine", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when thioridazine is combined with Vandetanib.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with quinidine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Ibutilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Ibutilide.", "severity": 4}
{"drug1": "quinidine", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quinidine is combined with Vandetanib.", "severity": 4}
{"drug1": "sotalol", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with pimozide.", "severity": 4}
{"drug1": "domperidone", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when domperidone is combined with Vandetanib.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Escitalopram.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Fencamfamin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Fencamfamin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Flupentixol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Dronedarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Dronedarone.", "severity": 4}
{"drug1": "Lumefantrine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Lumefantrine is combined with Artemether.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "amoxapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with amoxapine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with quetiapine.", "severity": 4}
{"drug1": "Quinine", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with pimozide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Paliperidone is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "pentamidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with pentamidine.", "severity": 4}
{"drug1": "sotalol", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Quinine", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with Vandetanib.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Paliperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Ibutilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Ibutilide.", "severity": 4}
{"drug1": "pimozide", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pimozide is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with pimozide.", "severity": 4}
{"drug1": "sotalol", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Iloperidone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "ACETOPHENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with ACETOPHENAZINE.", "severity": 4}
{"drug1": "trimethoprim", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when trimethoprim is combined with Lumefantrine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with pimozide.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Lumefantrine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "ritodrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with ritodrine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "chloroquine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with chloroquine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Escitalopram.", "severity": 4}
{"drug1": "quinidine", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quinidine is combined with Paliperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "cisapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with cisapride.", "severity": 4}
{"drug1": "proguanil", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when proguanil is combined with Lumefantrine.", "severity": 4}
{"drug1": "ATOVAQUONE", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when ATOVAQUONE is combined with Lumefantrine.", "severity": 4}
{"drug1": "quinidine", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quinidine is combined with Asenapine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "periciazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with periciazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "protriptyline", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with protriptyline.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Nilotinib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Nilotinib.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with Vandetanib.", "severity": 4}
{"drug1": "Quinine", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with Asenapine.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with quinidine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "zotepine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with zotepine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "MELPERONE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with MELPERONE.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with domperidone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "ATOVAQUONE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with ATOVAQUONE.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Paliperidone.", "severity": 4}
{"drug1": "SULFADOXINE", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when SULFADOXINE is combined with Lumefantrine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Vandetanib.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "enoxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with enoxacin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with Artemether.", "severity": 4}
{"drug1": "cisapride", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Asenapine.", "severity": 4}
{"drug1": "SULFALENE", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when SULFALENE is combined with Lumefantrine.", "severity": 4}
{"drug1": "sotalol", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Escitalopram.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "tiapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with tiapride.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "anagrelide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with anagrelide.", "severity": 4}
{"drug1": "cisapride", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Flupentixol.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "papaverine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with papaverine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Methadyl acetate", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Methadyl acetate.", "severity": 4}
{"drug1": "sotalol", "drug2": "Nilotinib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Nilotinib.", "severity": 4}
{"drug1": "domperidone", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when domperidone is combined with quetiapine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with domperidone.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PRIMAQUINE is combined with Artemether.", "severity": 4}
{"drug1": "doxycycline", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when doxycycline is combined with Lumefantrine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Pizotifen", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Pizotifen.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with quinidine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "probucol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with probucol.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "cocaine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with cocaine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "ondansetron", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with ondansetron.", "severity": 4}
{"drug1": "toremifene", "drug2": "thioridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with thioridazine.", "severity": 4}
{"drug1": "quinidine", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quinidine is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Isoconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Isoconazole.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "cinoxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with cinoxacin.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Lumefantrine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Lopinavir", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Lopinavir.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "butorphanol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with butorphanol.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with Asenapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "Quinine", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with sotalol.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Toloxatone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Toloxatone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "cisapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with cisapride.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "cilostazol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with cilostazol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Nilotinib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Nilotinib.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "sparfloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with sparfloxacin.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "chlorprothixene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with chlorprothixene.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Vandetanib.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "amiodarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with amiodarone.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "amiodarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with amiodarone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "isoetharine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with isoetharine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Quinine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Quinine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Quinine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Quinine.", "severity": 4}
{"drug1": "cisapride", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with quinidine.", "severity": 4}
{"drug1": "toremifene", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Butoconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Butoconazole.", "severity": 4}
{"drug1": "pimozide", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pimozide is combined with arsenic trioxide.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Vandetanib.", "severity": 4}
{"drug1": "sotalol", "drug2": "Lopinavir", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Lopinavir.", "severity": 4}
{"drug1": "toremifene", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Iloperidone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Asenapine.", "severity": 4}
{"drug1": "pyrimethamine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pyrimethamine is combined with Artemether.", "severity": 4}
{"drug1": "fluoxetine", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when fluoxetine is combined with Vandetanib.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "citalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with citalopram.", "severity": 4}
{"drug1": "disopyramide", "drug2": "thioridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with thioridazine.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Artemether.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Tianeptine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Tianeptine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Sertaconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Sertaconazole.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Pipamperone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Pipamperone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Gemifloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Gemifloxacin.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Quinine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Quinine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "clotrimazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with clotrimazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Ibutilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Ibutilide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "doxycycline", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with doxycycline.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "terconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with terconazole.", "severity": 4}
{"drug1": "anagrelide", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with quinidine.", "severity": 4}
{"drug1": "cisapride", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Dothiepin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Dothiepin.", "severity": 4}
{"drug1": "cisapride", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Lumefantrine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with domperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "mesoridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with mesoridazine.", "severity": 4}
{"drug1": "doxycycline", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when doxycycline is combined with Artemether.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Artemether.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Levomepromazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Levomepromazine.", "severity": 4}
{"drug1": "toremifene", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with pimozide.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Nilotinib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Nilotinib.", "severity": 4}
{"drug1": "disopyramide", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with domperidone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Dronedarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Dronedarone.", "severity": 4}
{"drug1": "SULFADOXINE", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when SULFADOXINE is combined with Artemether.", "severity": 4}
{"drug1": "sotalol", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with domperidone.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Escitalopram.", "severity": 4}
{"drug1": "quinacrine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quinacrine is combined with Lumefantrine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Asenapine is combined with Artemether.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "methadone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with methadone.", "severity": 4}
{"drug1": "citalopram", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when citalopram is combined with Vandetanib.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "bepridil", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with bepridil.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "thioridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with thioridazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Tapentadol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Tapentadol.", "severity": 4}
{"drug1": "Paliperidone", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Vandetanib.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Asenapine.", "severity": 4}
{"drug1": "domperidone", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when domperidone is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "sotalol", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Lumefantrine.", "severity": 4}
{"drug1": "hydroxychloroquine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when hydroxychloroquine is combined with Lumefantrine.", "severity": 4}
{"drug1": "citalopram", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when citalopram is combined with pimozide.", "severity": 4}
{"drug1": "disopyramide", "drug2": "quinidine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with quinidine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "levorphanol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with levorphanol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Dimetacrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Dimetacrine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Dofetilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Dofetilide.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "azithromycin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with azithromycin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Lopinavir", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with Lopinavir.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Lopinavir", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Lopinavir.", "severity": 4}
{"drug1": "toremifene", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Vandetanib.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "DEZOCINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with DEZOCINE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Milnacipran", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Milnacipran.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "formoterol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with formoterol.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "sevoflurane", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with sevoflurane.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Flupentixol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Arformoterol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Arformoterol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "MOLINDONE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with MOLINDONE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "hydroxychloroquine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with hydroxychloroquine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with pimozide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Aceprometazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Aceprometazine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Dronedarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Dronedarone.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Iloperidone.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when chloroquine is combined with Lumefantrine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "amiodarone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with amiodarone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "fluconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with fluconazole.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "haloperidol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with haloperidol.", "severity": 4}
{"drug1": "cisapride", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "disopyramide", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with quetiapine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "flecainide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with flecainide.", "severity": 4}
{"drug1": "cisapride", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "quinacrine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quinacrine is combined with Artemether.", "severity": 4}
{"drug1": "quinidine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when quinidine is combined with Lumefantrine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with Escitalopram.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "droperidol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with droperidol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "tranylcypromine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with tranylcypromine.", "severity": 4}
{"drug1": "PRIMAQUINE", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PRIMAQUINE is combined with Lumefantrine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with sotalol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "ELIGLUSTAT", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vandetanib is combined with ELIGLUSTAT.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Agomelatine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Agomelatine.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Artemether.", "severity": 4}
{"drug1": "sotalol", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Artemether.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "toremifene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with toremifene.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "5-hydroxy-L-tryptophan", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with 5-hydroxy-L-tryptophan.", "severity": 4}
{"drug1": "Quinine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with Artemether.", "severity": 4}
{"drug1": "domperidone", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when domperidone is combined with Asenapine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Levomepromazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Levomepromazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Asenapine.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Iloperidone.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Escitalopram.", "severity": 4}
{"drug1": "sotalol", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with Asenapine.", "severity": 4}
{"drug1": "toremifene", "drug2": "Asenapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Asenapine.", "severity": 4}
{"drug1": "Escitalopram", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Escitalopram is combined with Vandetanib.", "severity": 4}
{"drug1": "proguanil", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when proguanil is combined with Artemether.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "HEXOPRENALINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with HEXOPRENALINE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "bifonazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with bifonazole.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "anagrelide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with anagrelide.", "severity": 4}
{"drug1": "mefloquine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when mefloquine is combined with Lumefantrine.", "severity": 4}
{"drug1": "cisapride", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Paliperidone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "isocarboxazid", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with isocarboxazid.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Ibutilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Ibutilide.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Iloperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Escitalopram.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with sotalol.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "josamycin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with josamycin.", "severity": 4}
{"drug1": "disopyramide", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with arsenic trioxide.", "severity": 4}
{"drug1": "toremifene", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with arsenic trioxide.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with quetiapine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Phenelzine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Phenelzine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "fluoxetine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with fluoxetine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Normethadone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Normethadone.", "severity": 4}
{"drug1": "citalopram", "drug2": "Ibutilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when citalopram is combined with Ibutilide.", "severity": 4}
{"drug1": "domperidone", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when domperidone is combined with Paliperidone.", "severity": 4}
{"drug1": "pimozide", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pimozide is combined with Vandetanib.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "FLUPHENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with FLUPHENAZINE.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "oxaliplatin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with oxaliplatin.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Vandetanib.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Artesunate", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Artesunate.", "severity": 4}
{"drug1": "SULFALENE", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when SULFALENE is combined with Artemether.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Fluspirilene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Fluspirilene.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "sulpiride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with sulpiride.", "severity": 4}
{"drug1": "amodiaquine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when amodiaquine is combined with Artemether.", "severity": 4}
{"drug1": "disopyramide", "drug2": "cisapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with cisapride.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "ROSOXACIN", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with ROSOXACIN.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "metaproterenol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with metaproterenol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "cisapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with cisapride.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "citalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with citalopram.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with quetiapine.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "disopyramide", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when disopyramide is combined with Paliperidone.", "severity": 4}
{"drug1": "cisapride", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Escitalopram.", "severity": 4}
{"drug1": "anagrelide", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "paroxetine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with paroxetine.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "disopyramide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with disopyramide.", "severity": 4}
{"drug1": "Quinine", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with Flupentixol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "thioridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with thioridazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "sulpiride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with sulpiride.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "ciprofloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with ciprofloxacin.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "amisulpride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with amisulpride.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Lumefantrine.", "severity": 4}
{"drug1": "TETRABENAZINE", "drug2": "Vemurafenib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when TETRABENAZINE is combined with Vemurafenib.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Quinine", "drug2": "toremifene", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with toremifene.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "chloroquine", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when chloroquine is combined with Artemether.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "loxapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with loxapine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Remoxipride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Remoxipride.", "severity": 4}
{"drug1": "cisapride", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with domperidone.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "Ibutilide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Ibutilide.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "disopyramide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with disopyramide.", "severity": 4}
{"drug1": "pimozide", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pimozide is combined with domperidone.", "severity": 4}
{"drug1": "anagrelide", "drug2": "thioridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with thioridazine.", "severity": 4}
{"drug1": "cisapride", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with quetiapine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "PROCATEROL", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with PROCATEROL.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "LEVOFLOXACIN", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with LEVOFLOXACIN.", "severity": 4}
{"drug1": "Quinine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with Lumefantrine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Gatifloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Gatifloxacin.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "Nilotinib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with Nilotinib.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Artemether", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Artemether.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "donepezil", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with donepezil.", "severity": 4}
{"drug1": "toremifene", "drug2": "Flupentixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Flupentixol.", "severity": 4}
{"drug1": "pyrimethamine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when pyrimethamine is combined with Lumefantrine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "thioridazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with thioridazine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "nalbuphine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with nalbuphine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "SULFALENE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with SULFALENE.", "severity": 4}
{"drug1": "amodiaquine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when amodiaquine is combined with Lumefantrine.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "moxifloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with moxifloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Iloperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with Iloperidone.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "erythromycin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with erythromycin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "Lopinavir", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with Lopinavir.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "toremifene", "drug2": "Escitalopram", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with Escitalopram.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Lumefantrine.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "sotalol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with sotalol.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with domperidone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Thioproperazine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Thioproperazine.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Paliperidone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Isavuconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Isavuconazole.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "pyrimethamine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with pyrimethamine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "TETRABENAZINE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with TETRABENAZINE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Vorinostat", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Vorinostat.", "severity": 4}
{"drug1": "Ibutilide", "drug2": "cisapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ibutilide is combined with cisapride.", "severity": 4}
{"drug1": "cisapride", "drug2": "PROCAINAMIDE", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with PROCAINAMIDE.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "fluconazole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with fluconazole.", "severity": 4}
{"drug1": "sotalol", "drug2": "cisapride", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when sotalol is combined with cisapride.", "severity": 4}
{"drug1": "Artesunate", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Artesunate is combined with Lumefantrine.", "severity": 4}
{"drug1": "Asenapine", "drug2": "Lumefantrine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Asenapine is combined with Lumefantrine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "pimozide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with pimozide.", "severity": 4}
{"drug1": "amiodarone", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when amiodarone is combined with Paliperidone.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Pirlindole", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Pirlindole.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with domperidone.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "Paliperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with Paliperidone.", "severity": 4}
{"drug1": "Ziprasidone", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "anagrelide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with anagrelide.", "severity": 4}
{"drug1": "Ribociclib", "drug2": "Gatifloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Gatifloxacin.", "severity": 4}
{"drug1": "PROCAINAMIDE", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when PROCAINAMIDE is combined with arsenic trioxide.", "severity": 4}
{"drug1": "cisapride", "drug2": "Zuclopenthixol", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when cisapride is combined with Zuclopenthixol.", "severity": 4}
{"drug1": "anagrelide", "drug2": "Vandetanib", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with Vandetanib.", "severity": 4}
{"drug1": "toremifene", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when toremifene is combined with quetiapine.", "severity": 4}
{"drug1": "anagrelide", "drug2": "disopyramide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when anagrelide is combined with disopyramide.", "severity": 4}
{"drug1": "Quinine", "drug2": "arsenic trioxide", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Quinine is combined with arsenic trioxide.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "Trovafloxacin", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Trovafloxacin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when arsenic trioxide is combined with domperidone.", "severity": 4}
{"drug1": "Flupentixol", "drug2": "domperidone", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Flupentixol is combined with domperidone.", "severity": 4}
{"drug1": "Dofetilide", "drug2": "quetiapine", "interaction_type": 33, "interaction_text": "The risk or severity of QTc prolongation can be increased when Dofetilide is combined with quetiapine.", "severity": 4}
{"drug1": "Nelarabine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Nelarabine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Ruxolitinib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Ruxolitinib.", "severity": 2}
{"drug1": "5-azacytidine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "5-azacytidine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "ifosfamide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "cytarabine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "rapamycin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of rapamycin.", "severity": 2}
{"drug1": "lomustine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "lomustine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Tofacitinib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "triamcinolone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Panobinostat may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "actinomycin D", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of actinomycin D.", "severity": 2}
{"drug1": "mechlorethamine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "mechlorethamine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Pemetrexed", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Pemetrexed.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "tretinoin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "vincristine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Lenalidomide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Lenalidomide.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "irinotecan", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of irinotecan.", "severity": 2}
{"drug1": "temozolomide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "temozolomide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "cyclosporin A may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Panobinostat", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Panobinostat.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "BENZNIDAZOLE", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of BENZNIDAZOLE.", "severity": 2}
{"drug1": "busulfan", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "busulfan may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Stepronin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Stepronin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "lomustine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of lomustine.", "severity": 2}
{"drug1": "altretamine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "altretamine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "mitoxantrone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of mitoxantrone.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "vinorelbine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of vinorelbine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "DEFLAZACORT may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Fludarabine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Fludarabine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "vinorelbine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "DEFLAZACORT", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of DEFLAZACORT.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "amsacrine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of amsacrine.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "carboplatin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "procarbazine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "thioguanine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "thioguanine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "mitoxantrone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "cytarabine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of cytarabine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "5-Fluorouracil may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "methotrexate", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of methotrexate.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "IMIQUIMOD may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "oxaliplatin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Ibrutinib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Ibrutinib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "dexamethasone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Nilotinib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "cyclosporin A", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of cyclosporin A.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Apremilast may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "mechlorethamine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of mechlorethamine.", "severity": 2}
{"drug1": "Pemetrexed", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Pemetrexed may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "CAPECITABINE", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "CAPECITABINE may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Icatibant may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "betamethasone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Fludarabine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Fludarabine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Pralatrexate may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Pazopanib may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "etoposide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "etoposide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Idelalisib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "temozolomide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "temozolomide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "busulfan", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "busulfan may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Ruxolitinib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "melphalan", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "melphalan may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Sorafenib may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "ifosfamide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of ifosfamide.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Nilotinib may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "CAPECITABINE", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "CAPECITABINE may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Sorafenib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Sorafenib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Imatinib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "IDARUBICIN", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of IDARUBICIN.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Dimethyl fumarate", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Dimethyl fumarate.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Pralatrexate", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Pralatrexate.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "pentostatin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of pentostatin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "daunorubicin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "teniposide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "teniposide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Teriflunomide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "prednisone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "prednisone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "methylprednisolone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of methylprednisolone.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "carboplatin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of carboplatin.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Pomalidomide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Pomalidomide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "DEFLAZACORT may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "budesonide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "budesonide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "fludrocortisone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "PIRFENIDONE may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "cyclosporin A", "interaction_type": 34, "interaction_text": "cyclophosphamide may increase the immunosuppressive activities of cyclosporin A.", "severity": 2}
{"drug1": "azathioprine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "azathioprine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "actinomycin D may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "mitomycin C", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "mitomycin C may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Teriflunomide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Teriflunomide.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Sunitinib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Sunitinib.", "severity": 2}
{"drug1": "cisplatin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "cisplatin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "streptozocin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of streptozocin.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "triamcinolone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of triamcinolone.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Pazopanib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Pazopanib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "mycophenolate mofetil may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "carmustine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "carmustine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "daunorubicin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of daunorubicin.", "severity": 2}
{"drug1": "lomustine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "lomustine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "hydroxyurea", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "hydroxyurea may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Dimethyl fumarate", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Dimethyl fumarate may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Cladribine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Cladribine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Ibrutinib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Cladribine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Cladribine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "amsacrine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "vindesine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of vindesine.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "vincristine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of vincristine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "doxorubicin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "mitomycin C", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of mitomycin C.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Pazopanib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "actinomycin D may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Apremilast may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "altretamine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of altretamine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "vinblastine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Palbociclib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Palbociclib.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "hydrocortisone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "rapamycin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Epirubicin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Epirubicin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "5-Fluorouracil may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "mechlorethamine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "mechlorethamine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "L-phenylalanine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "L-phenylalanine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "vinblastine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Temsirolimus may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "tretinoin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "thiotepa may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "gemcitabine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "gemcitabine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Dasatinib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Dasatinib.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Icatibant may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Vilanterol may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Clofarabine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Clofarabine.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "glimepiride", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of glimepiride.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "rapamycin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "docetaxel may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Panobinostat may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "hydroxyurea", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "hydroxyurea may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "docetaxel may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "cyclophosphamide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of cyclophosphamide.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "busulfan", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of busulfan.", "severity": 2}
{"drug1": "altretamine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "altretamine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "streptozocin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "streptozocin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "pentostatin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "pentostatin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Temsirolimus", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Temsirolimus.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "hydroxyurea", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of hydroxyurea.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Temsirolimus may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "mitomycin C", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "mitomycin C may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "mitoxantrone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "ifosfamide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Pimecrolimus", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Pimecrolimus.", "severity": 2}
{"drug1": "BENZNIDAZOLE", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "BENZNIDAZOLE may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Sunitinib may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "cytarabine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Pimecrolimus may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "CORTISONE ACETATE may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Idelalisib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Idelalisib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "tacrolimus may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "mycophenolate mofetil may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Pomalidomide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "carboplatin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "glimepiride may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Dimethyl fumarate", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Dimethyl fumarate may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "dexamethasone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "IMIQUIMOD", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of IMIQUIMOD.", "severity": 2}
{"drug1": "streptozocin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "streptozocin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Palbociclib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Lenalidomide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Fludarabine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Fludarabine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "chlorambucil", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "chlorambucil may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "cyclophosphamide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Nilotinib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Nilotinib.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "IMIQUIMOD may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "fludrocortisone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Cladribine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Cladribine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "hydrocortisone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "IDARUBICIN may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "docetaxel", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of docetaxel.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "tacrolimus may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "6-Mercaptopurine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "mycophenolate mofetil", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "CABAZITAXEL may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "floxuridine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of floxuridine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "methotrexate may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "oxaliplatin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of oxaliplatin.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "topotecan", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of topotecan.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Epirubicin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Epirubicin.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "teniposide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of teniposide.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "betamethasone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of betamethasone.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "fludrocortisone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of fludrocortisone.", "severity": 2}
{"drug1": "BENZNIDAZOLE", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "BENZNIDAZOLE may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Epirubicin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Epirubicin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Sunitinib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "gemcitabine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "gemcitabine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "L-phenylalanine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "L-phenylalanine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "mycophenolic acid may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "prednisone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of prednisone.", "severity": 2}
{"drug1": "bleomycin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "bleomycin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "pentostatin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "pentostatin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "estramustine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "estramustine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Pomalidomide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Stepronin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Stepronin.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "5-azacytidine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of 5-azacytidine.", "severity": 2}
{"drug1": "5-azacytidine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "5-azacytidine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Imatinib", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Imatinib.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "mycophenolic acid may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "6-Mercaptopurine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of 6-Mercaptopurine.", "severity": 2}
{"drug1": "vindesine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "vindesine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "triamcinolone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "tretinoin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of tretinoin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "daunorubicin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "5-Fluorouracil", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of 5-Fluorouracil.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "cisplatin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of cisplatin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "procarbazine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "thalidomide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Nelarabine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Nelarabine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "cyclosporin A may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "thioguanine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of thioguanine.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "mycophenolic acid", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "dexamethasone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of dexamethasone.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "L-phenylalanine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of L-phenylalanine.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "gemcitabine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of gemcitabine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "vincristine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "azathioprine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "azathioprine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "procarbazine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of procarbazine.", "severity": 2}
{"drug1": "melphalan", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "melphalan may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "azathioprine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of azathioprine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Dasatinib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "cyclophosphamide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "doxorubicin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of doxorubicin.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "thalidomide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "vindesine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "vindesine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "betamethasone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Lenalidomide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "cisplatin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "cisplatin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "dacarbazine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of dacarbazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "methylprednisolone may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "temozolomide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of temozolomide.", "severity": 2}
{"drug1": "Pemetrexed", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Pemetrexed may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "floxuridine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "floxuridine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "etoposide", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "etoposide may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Sorafenib may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "CABAZITAXEL may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Clofarabine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Apremilast", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Apremilast.", "severity": 2}
{"drug1": "budesonide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "budesonide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "CORTISONE ACETATE may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "dacarbazine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "CAPECITABINE", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of CAPECITABINE.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "hydrocortisone", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of hydrocortisone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "methotrexate may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Trabectedin may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "dacarbazine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "thiotepa may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Ibrutinib may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "irinotecan may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "prednisone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "prednisone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Trabectedin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Trabectedin.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "vinorelbine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "glimepiride may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "budesonide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of budesonide.", "severity": 2}
{"drug1": "teniposide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "teniposide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Vilanterol may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Gallium nitrate", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Gallium nitrate.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "bleomycin", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of bleomycin.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "chlorambucil", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of chlorambucil.", "severity": 2}
{"drug1": "chlorambucil", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "chlorambucil may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "IDARUBICIN may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "6-Mercaptopurine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "leflunomide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of leflunomide.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Ruxolitinib may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Teriflunomide may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Nelarabine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Nelarabine.", "severity": 2}
{"drug1": "Stepronin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Stepronin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "bleomycin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "bleomycin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "tacrolimus", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of tacrolimus.", "severity": 2}
{"drug1": "carmustine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "carmustine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "irinotecan may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Imatinib may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "amsacrine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Gallium nitrate", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Gallium nitrate may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "methylprednisolone may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "topotecan may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Trabectedin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "thioguanine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "thioguanine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Gallium nitrate", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Gallium nitrate may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "CORTISONE ACETATE", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of CORTISONE ACETATE.", "severity": 2}
{"drug1": "topotecan", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "topotecan may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "oxaliplatin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "etoposide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of etoposide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Fingolimod", "interaction_type": 34, "interaction_text": "Clofarabine may increase the immunosuppressive activities of Fingolimod.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "doxorubicin may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Icatibant", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Icatibant.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "PIRFENIDONE", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "CABAZITAXEL", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of CABAZITAXEL.", "severity": 2}
{"drug1": "estramustine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "estramustine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "Pralatrexate may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "thalidomide", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of thalidomide.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "melphalan", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of melphalan.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "thiotepa", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of thiotepa.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "carmustine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of carmustine.", "severity": 2}
{"drug1": "floxuridine", "drug2": "Tofacitinib", "interaction_type": 34, "interaction_text": "floxuridine may increase the immunosuppressive activities of Tofacitinib.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "estramustine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of estramustine.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Vilanterol", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of Vilanterol.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "vinblastine", "interaction_type": 34, "interaction_text": "Roflumilast may increase the immunosuppressive activities of vinblastine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "perphenazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of perphenazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Flupentixol", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Flupentixol.", "severity": 3}
{"drug1": "teniposide", "drug2": "vincristine", "interaction_type": 35, "interaction_text": "teniposide may increase the neurotoxic activities of vincristine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Tianeptine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Tianeptine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Dothiepin", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Dothiepin.", "severity": 3}
{"drug1": "lithium ion", "drug2": "BREXPIPRAZOLE", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of BREXPIPRAZOLE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "tiapride", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of tiapride.", "severity": 3}
{"drug1": "lithium ion", "drug2": "MELPERONE", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of MELPERONE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "protriptyline", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of protriptyline.", "severity": 3}
{"drug1": "lithium ion", "drug2": "clozapine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of clozapine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Aceprometazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Aceprometazine.", "severity": 3}
{"drug1": "VERAPAMIL", "drug2": "lithium ion", "interaction_type": 35, "interaction_text": "VERAPAMIL may increase the neurotoxic activities of lithium ion.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Fencamfamin", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Fencamfamin.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Cyamemazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Cyamemazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "reserpine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of reserpine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "SERTINDOLE", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of SERTINDOLE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Paliperidone", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Paliperidone.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Pipamperone", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Pipamperone.", "severity": 3}
{"drug1": "lithium ion", "drug2": "amitriptyline", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of amitriptyline.", "severity": 3}
{"drug1": "lithium ion", "drug2": "clomipramine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of clomipramine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "chlorprothixene", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of chlorprothixene.", "severity": 3}
{"drug1": "lithium ion", "drug2": "risperidone", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of risperidone.", "severity": 3}
{"drug1": "lithium ion", "drug2": "imipramine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of imipramine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Perospirone", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Perospirone.", "severity": 3}
{"drug1": "ethanol", "drug2": "D-cycloserine", "interaction_type": 35, "interaction_text": "ethanol may increase the neurotoxic activities of D-cycloserine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "cyclobenzaprine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of cyclobenzaprine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "desipramine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of desipramine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "prochlorperazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of prochlorperazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "quetiapine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of quetiapine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Cariprazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Cariprazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "MOLINDONE", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of MOLINDONE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "ACETOPHENAZINE", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of ACETOPHENAZINE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "periciazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of periciazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "ondansetron", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of ondansetron.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "imipenem", "interaction_type": 35, "interaction_text": "cyclosporin A may increase the neurotoxic activities of imipenem.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Fluspirilene", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Fluspirilene.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Iloperidone", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Iloperidone.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Asenapine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Asenapine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "amisulpride", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of amisulpride.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Ziprasidone", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Ziprasidone.", "severity": 3}
{"drug1": "diltiazem", "drug2": "lithium ion", "interaction_type": 35, "interaction_text": "diltiazem may increase the neurotoxic activities of lithium ion.", "severity": 3}
{"drug1": "lithium ion", "drug2": "mirtazapine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of mirtazapine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "olanzapine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of olanzapine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "FLUPHENAZINE", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of FLUPHENAZINE.", "severity": 3}
{"drug1": "lithium ion", "drug2": "zotepine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of zotepine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "thioridazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of thioridazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Aripiprazole", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Aripiprazole.", "severity": 3}
{"drug1": "lithium ion", "drug2": "loxapine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of loxapine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Remoxipride", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Remoxipride.", "severity": 3}
{"drug1": "lithium ion", "drug2": "amoxapine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of amoxapine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Zuclopenthixol", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Zuclopenthixol.", "severity": 3}
{"drug1": "lithium ion", "drug2": "nortriptyline", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of nortriptyline.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Pipotiazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Pipotiazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "trimipramine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of trimipramine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "thiothixene", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of thiothixene.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Thioproperazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Thioproperazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "mesoridazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of mesoridazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "doxepin", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of doxepin.", "severity": 3}
{"drug1": "lithium ion", "drug2": "promazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of promazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "haloperidol", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of haloperidol.", "severity": 3}
{"drug1": "lithium ion", "drug2": "sulpiride", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of sulpiride.", "severity": 3}
{"drug1": "lithium ion", "drug2": "Lurasidone", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of Lurasidone.", "severity": 3}
{"drug1": "lithium ion", "drug2": "trifluoperazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of trifluoperazine.", "severity": 3}
{"drug1": "lithium ion", "drug2": "pimozide", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of pimozide.", "severity": 3}
{"drug1": "lithium ion", "drug2": "triflupromazine", "interaction_type": 35, "interaction_text": "lithium ion may increase the neurotoxic activities of triflupromazine.", "severity": 3}
{"drug1": "amisulpride", "drug2": "thioridazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of thioridazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "SERTINDOLE", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of SERTINDOLE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "periciazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of periciazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "reserpine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of reserpine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "chlorprothixene", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of chlorprothixene.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Aripiprazole", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Aripiprazole.", "severity": 2}
{"drug1": "sulpiride", "drug2": "perphenazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of perphenazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Pipamperone", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Pipamperone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "perphenazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of perphenazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Cariprazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Cariprazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "trifluoperazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of trifluoperazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Fluspirilene", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Fluspirilene.", "severity": 2}
{"drug1": "sulpiride", "drug2": "reserpine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of reserpine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "SERTINDOLE", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of SERTINDOLE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Cariprazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Cariprazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "risperidone", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of risperidone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "clozapine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of clozapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "periciazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of periciazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "quetiapine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of quetiapine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "tiapride", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of tiapride.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Remoxipride", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Remoxipride.", "severity": 2}
{"drug1": "amisulpride", "drug2": "loxapine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of loxapine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Lurasidone", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Lurasidone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "ondansetron", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of ondansetron.", "severity": 2}
{"drug1": "sulpiride", "drug2": "prochlorperazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of prochlorperazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "quetiapine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of quetiapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Perospirone", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Perospirone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Fencamfamin", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Fencamfamin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Aceprometazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Aceprometazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "ACETOPHENAZINE", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "MOLINDONE", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of MOLINDONE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "zotepine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of zotepine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "MELPERONE", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of MELPERONE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "olanzapine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of olanzapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "mesoridazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of mesoridazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Aripiprazole", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Aripiprazole.", "severity": 2}
{"drug1": "sulpiride", "drug2": "chlorprothixene", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of chlorprothixene.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Cyamemazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Cyamemazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "promazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of promazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Pipotiazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Pipotiazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "thiothixene", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of thiothixene.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Thioproperazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Thioproperazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "FLUPHENAZINE", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Zuclopenthixol", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Zuclopenthixol.", "severity": 2}
{"drug1": "amisulpride", "drug2": "BREXPIPRAZOLE", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "promazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of promazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Iloperidone", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Iloperidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "BREXPIPRAZOLE", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "pimozide", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of pimozide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Cyamemazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Cyamemazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "risperidone", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of risperidone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Aceprometazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Aceprometazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ondansetron", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of ondansetron.", "severity": 2}
{"drug1": "amisulpride", "drug2": "prochlorperazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of prochlorperazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Ziprasidone", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Ziprasidone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "olanzapine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of olanzapine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Perospirone", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Perospirone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "FLUPHENAZINE", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Flupentixol", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Flupentixol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "loxapine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of loxapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Lurasidone", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Lurasidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Ziprasidone", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Ziprasidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "thioridazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of thioridazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Asenapine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Asenapine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "MELPERONE", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of MELPERONE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "zotepine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of zotepine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Fluspirilene", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Fluspirilene.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Paliperidone", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Paliperidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "clozapine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of clozapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Asenapine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Asenapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Paliperidone", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Paliperidone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Pipotiazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Pipotiazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Thioproperazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Thioproperazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "thiothixene", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of thiothixene.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Zuclopenthixol", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of Zuclopenthixol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Flupentixol", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Flupentixol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "triflupromazine", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of triflupromazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Pipamperone", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Pipamperone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "trifluoperazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of trifluoperazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "haloperidol", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of haloperidol.", "severity": 2}
{"drug1": "amisulpride", "drug2": "mesoridazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of mesoridazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Iloperidone", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Iloperidone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "triflupromazine", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of triflupromazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Fencamfamin", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of Fencamfamin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "MOLINDONE", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of MOLINDONE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "haloperidol", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of haloperidol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ACETOPHENAZINE", "interaction_type": 36, "interaction_text": "sulpiride may increase the antipsychotic activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "pimozide", "interaction_type": 36, "interaction_text": "amisulpride may increase the antipsychotic activities of pimozide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "timolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "atenolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "droxidopa", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "triamterene", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "timolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "celiprolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "timolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "clonidine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "NICORANDIL may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Bimatoprost may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "irbesartan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "floctafenine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of floctafenine.", "severity": 2}
{"drug1": "propranolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "carvedilol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "sotalol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "tibolone", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "tibolone may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "propranolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "propranolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "phenoxybenzamine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "penbutolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "alprenolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "timolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "minoxidil may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "isradipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "isradipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "nicardipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "nicardipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "atenolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "labetalol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "practolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "sotalol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "practolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "alprenolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "captopril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "guanabenz", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "triamterene", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "pergolide", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "labetalol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "triamterene", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "labetalol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "atenolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "carvedilol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "nadolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "nadolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "pargyline", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "pargyline may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "epinephrine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "triamterene", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "nadolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "pargyline", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "pargyline may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "hydralazine", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "atenolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "clonidine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "hydralazine", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "celiprolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "nadolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "nadolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "isradipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "practolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "hydralazine", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "nadolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "clonidine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "timolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "timolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "triamterene", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "triamterene", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "atenolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "sotalol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "nadolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "nadolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "nadolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "nadolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "timolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "chloroquine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of chloroquine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "atenolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "labetalol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "triamterene", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "guanabenz", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "Bretylium", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Bretylium may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "alprenolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "sotalol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "propranolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "epoprostenol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "timolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "captopril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "sotalol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "chlorthalidone may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "alprenolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "atenolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "atenolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "atenolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "labetalol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "droxidopa", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Macitentan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "penbutolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Travoprost may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "pergolide", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "practolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Pentolinium may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "practolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "timolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "acebutolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "pergolide", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "nadolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "nadolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "propranolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "labetalol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "atenolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "triamterene", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "propranolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "quinapril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "atenolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "atenolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "atenolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "atenolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "propranolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "labetalol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "nadolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "nadolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "nadolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "nadolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "timolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "risperidone", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Telmisartan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "sotalol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "nadolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "brimonidine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "duloxetine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of duloxetine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "celiprolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "cyclothiazide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "fosinopril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "clonidine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "clonidine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "ramipril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "guanabenz", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "lisinopril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Ambrisentan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "hydralazine", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "nadolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "sotalol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "polythiazide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "polythiazide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Remikiren may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "MOXONIDINE may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "triamterene", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "sotalol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "practolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "practolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "atenolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "propranolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "Spirapril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "Spirapril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "naphazoline", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "practolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "acebutolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "acebutolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "timolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "penbutolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "atenolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Ambrisentan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "acebutolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "practolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "naphazoline", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "propranolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "venlafaxine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of venlafaxine.", "severity": 2}
{"drug1": "nadolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "mecamylamine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "atenolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "atenolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "practolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "spironolactone", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "triamterene", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "nadolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "penbutolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "nadolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "triamterene", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "metolazone", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "metolazone may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "triamterene", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "duloxetine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of duloxetine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "triamterene", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "alprenolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "duloxetine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of duloxetine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "nadolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "timolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "apomorphine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "timolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "propranolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "labetalol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Nitroprusside may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "epoprostenol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "penbutolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "penbutolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "labetalol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "brimonidine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "brimonidine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "nadolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "guanabenz", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "alprenolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "TRIMETHAPHAN may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "felodipine", "drug2": "Melatonin", "interaction_type": 37, "interaction_text": "felodipine may decrease the antihypertensive activities of Melatonin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "benazepril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "labetalol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "chloroquine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of chloroquine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "celiprolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "triamterene", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Treprostinil may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "timolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "labetalol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "naphazoline", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "triamterene", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "triamterene", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "venlafaxine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of venlafaxine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "atenolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "ropinirole may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "sotalol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "indapamide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "indapamide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "spironolactone", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "atenolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "timolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "practolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "labetalol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "atenolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "labetalol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "labetalol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "enalapril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "duloxetine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of duloxetine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "labetalol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "naphazoline", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "felodipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "felodipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "sotalol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "BENDROFLUMETHIAZIDE may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "nadolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "ropinirole may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "GUANADREL may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "triamterene", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "acebutolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "timolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "METYROSINE may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "labetalol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "Etomidate", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "hydralazine", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "hydralazine", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "hydralazine", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "nadolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "acebutolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "propranolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "triamterene", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "celiprolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "propranolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Debrisoquine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "betaxolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "atenolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "floctafenine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of floctafenine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "triamterene", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "timolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "timolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "sotalol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "propranolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "brimonidine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "enalapril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "practolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "spironolactone", "drug2": "floctafenine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of floctafenine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "nilvadipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "atenolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "propranolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "timolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "penbutolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "nimodipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "nimodipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "labetalol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "naphazoline", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "tolazoline", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "tolazoline may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "GUANETHIDINE may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "labetalol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "venlafaxine", "interaction_type": 37, "interaction_text": "MOXONIDINE may decrease the antihypertensive activities of venlafaxine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "sotalol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "sotalol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "sotalol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "atenolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "nisoldipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "sotalol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "timolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "nicardipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "timolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "sotalol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "alprenolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "floctafenine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of floctafenine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Bimatoprost may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "celiprolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "alprenolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "latanoprost", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "latanoprost may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "acemetacin", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of acemetacin.", "severity": 2}
{"drug1": "sotalol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "sotalol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "sotalol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "betaxolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "labetalol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "labetalol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "sotalol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "hydroflumethiazide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "propranolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "atenolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "practolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "nisoldipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "clonidine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "atenolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "nadolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Unoprostone may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "fenoldopam may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "triamterene", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "celiprolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "celiprolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "tolazoline may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "metoprolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "nadolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "triamterene", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "enalapril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "triamterene", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "practolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "captopril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "practolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "metoprolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "practolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "penbutolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "propranolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "timolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "triamterene", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "nitrendipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "labetalol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "apomorphine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "MOXONIDINE may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "propranolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "nadolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "diltiazem may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "naphazoline", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "timolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "quinapril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "timolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "celiprolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "labetalol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "brimonidine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "nadolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "doxazosin may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Lacidipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "penbutolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "hydrochlorothiazide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Lercanidipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "atenolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "lisinopril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "betaxolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "droxidopa", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "practolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "triamterene", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Eprosartan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "atenolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "atenolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "sotalol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "fosinopril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "practolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "acemetacin", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of acemetacin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "acemetacin", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of acemetacin.", "severity": 2}
{"drug1": "triamterene", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "clonidine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "propranolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "timolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "sotalol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Eprosartan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "labetalol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "labetalol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "ramipril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "timolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "atenolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "propranolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "propranolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "nadolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "practolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "timolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "chlorthalidone may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "dorzolamide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "practolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "polythiazide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "nadolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "triamterene", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "droxidopa", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "sotalol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "timolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "atenolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "timolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Efonidipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "ramipril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "chloroquine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of chloroquine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "phenoxybenzamine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "tibolone", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "tibolone may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "timolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Melatonin", "interaction_type": 37, "interaction_text": "isradipine may decrease the antihypertensive activities of Melatonin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "sotalol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "manidipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "manidipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "propranolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "timolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "atenolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "alprenolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "methyldopa", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "methyldopa may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "captopril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "timolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "cilazapril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "Torasemide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Torasemide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "practolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "carvedilol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Torasemide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "nadolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "trandolapril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "chloroquine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of chloroquine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "risperidone", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "sotalol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "captopril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "sotalol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "penbutolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "acebutolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Melatonin", "interaction_type": 37, "interaction_text": "nicardipine may decrease the antihypertensive activities of Melatonin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "clonidine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "pergolide", "drug2": "duloxetine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of duloxetine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "nimodipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Olmesartan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "atenolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "DESERPIDINE may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "atenolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "naphazoline", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "atenolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "atenolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "penbutolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "sotalol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "metolazone", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "metolazone may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Spirapril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "risperidone", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "practolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "atenolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "quinapril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "practolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "practolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "enalapril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "penbutolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "practolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "carvedilol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "nadolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "practolol", "drug2": "acemetacin", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of acemetacin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "penbutolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "celiprolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "pergolide", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "practolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "naphazoline", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "chlorothiazide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "labetalol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "naphazoline", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "nadolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "chloroquine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of chloroquine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "propranolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "propranolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "labetalol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "sotalol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "propranolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "practolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "labetalol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "valsartan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "valsartan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "penbutolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "atenolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "practolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "atenolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Efonidipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Lercanidipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "penbutolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "timolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "labetalol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "naphazoline", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "labetalol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "labetalol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "DESERPIDINE may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "sotalol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "prazosin", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "prazosin may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "atenolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "sotalol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "diazoxide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "practolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "timolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "atenolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "labetalol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "atenolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "chloroquine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of chloroquine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "hydralazine", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "triamterene", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "nadolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Nitroprusside may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "labetalol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "acebutolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "triamterene", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "dorzolamide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "nadolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "triamterene", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "timolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "propranolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "atenolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "sotalol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "celiprolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "triamterene", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "venlafaxine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of venlafaxine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "trichlormethiazide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "timolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "timolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "labetalol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "droxidopa", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "practolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "methyldopa may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "triamterene", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "practolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "timolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "practolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "guanabenz", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "fosinopril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "irbesartan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "minoxidil may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "atenolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "triamterene", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Melatonin", "interaction_type": 37, "interaction_text": "Clevidipine may decrease the antihypertensive activities of Melatonin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "sotalol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "propranolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "timolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "timolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "propranolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "acebutolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "GUANETHIDINE may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "nadolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "latanoprost may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "propranolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "cyclothiazide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "atenolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "atenolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "atenolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "sotalol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "MOXONIDINE may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "timolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "timolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "timolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "timolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "labetalol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "nadolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "nadolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "sotalol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "timolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "labetalol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "naphazoline", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Bosentan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "tizanidine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "labetalol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "valsartan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "pergolide", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "practolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "practolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "fosinopril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Sitaxsentan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Terlipressin may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "nadolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "quinapril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "triamterene", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "nadolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "nadolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Unoprostone may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "celiprolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "atenolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "practolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "benazepril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "atenolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "captopril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "mecamylamine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "propranolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "nadolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "timolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "propranolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "PERINDOPRIL may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "labetalol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Candesartan cilexetil may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "tizanidine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "timolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "triamterene", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "practolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "triamterene", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "risperidone", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "risperidone", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "propranolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "nadolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "practolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "clonidine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "nadolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "atenolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Telmisartan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "timolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "timolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "benazepril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "penbutolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "felodipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "felodipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "hydrochlorothiazide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "atenolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "atenolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "timolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "acebutolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "apomorphine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "nadolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "venlafaxine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of venlafaxine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Olmesartan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "penbutolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "penbutolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "sotalol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "Macitentan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Macitentan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "risperidone", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "practolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "practolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "labetalol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "practolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "atenolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "penbutolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "labetalol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "diltiazem may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "nadolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "indapamide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "propranolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "clonidine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "clonidine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "labetalol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "practolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "practolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "betaxolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "penbutolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "pergolide", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "sotalol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "epinephrine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "nadolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "labetalol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "atenolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "labetalol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "ramipril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "hydralazine", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "carvedilol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "pergolide", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "bepridil", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "bepridil may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "fenoldopam may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "triamterene", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "epinephrine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "triamterene", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "nadolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "nadolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "timolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "timolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "propranolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "BENDROFLUMETHIAZIDE may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "timolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "triamterene", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "atenolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "timolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "sotalol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "propranolol", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "rescinnamine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "bepridil", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "bepridil may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "spironolactone", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "risperidone", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "betaxolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "alprenolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "labetalol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Debrisoquine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "guanabenz", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "venlafaxine", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of venlafaxine.", "severity": 2}
{"drug1": "propranolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "nadolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "triamterene", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Riociguat may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "penbutolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "nilvadipine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "quinapril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "hydralazine", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "timolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "acebutolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "hydroflumethiazide may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "atenolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "sotalol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "losartan", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "losartan may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "atenolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "sotalol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "penbutolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "timolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "alprenolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "norepinephrine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "practolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "sotalol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "sotalol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "atenolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "nadolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Etomidate", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "timolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "duloxetine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of duloxetine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "nadolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "nadolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "ramipril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Etomidate", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "triamterene", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "reserpine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Melatonin", "interaction_type": 37, "interaction_text": "nisoldipine may decrease the antihypertensive activities of Melatonin.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "hydralazine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "hydralazine", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "ropinirole may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "nadolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "nadolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "nadolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "triamterene", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "labetalol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "clonidine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "clonidine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "atenolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "enalapril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "metoprolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "risperidone", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Melatonin", "interaction_type": 37, "interaction_text": "nifedipine may decrease the antihypertensive activities of Melatonin.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "floctafenine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of floctafenine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "risperidone", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "sotalol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Melatonin", "interaction_type": 37, "interaction_text": "nimodipine may decrease the antihypertensive activities of Melatonin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "timolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "labetalol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "propranolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "triamterene", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "triamterene", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "propranolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "nitrendipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "timolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Etomidate", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "timolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "naphazoline", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Lacidipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "penbutolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "sotalol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "atenolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "betaxolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "Riociguat", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Riociguat may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "practolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "penbutolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "labetalol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "sotalol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "labetalol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "labetalol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "ropinirole may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "enalapril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "hydralazine", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "METYROSINE may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "propranolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "lisinopril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "triamterene", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "pergolide", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "acebutolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "triamterene", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "niflumic acid", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of niflumic acid.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "NICORANDIL may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clomipramine", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of clomipramine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "atenolol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "practolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "acemetacin", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of acemetacin.", "severity": 2}
{"drug1": "practolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "carvedilol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "tizanidine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "labetalol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "alprenolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "labetalol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "ERGOTAMINE may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "Lofexidine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "propranolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "propranolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "propranolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "floctafenine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of floctafenine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "practolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "sotalol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "sotalol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "sotalol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "GUANADREL may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "sulindac", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of sulindac.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "penbutolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "timolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "benazepril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "nadolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "nadolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "sotalol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "atenolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "dihydroergotamine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Terlipressin may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "timolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "timolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "propranolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "spironolactone", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "nadolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "penbutolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "PSEUDOEPHEDRINE may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "betaxolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "bromocriptine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "MOXONIDINE may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "ramipril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "risperidone", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "risperidone may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "MOEXIPRIL may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "nadolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "triamterene", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "labetalol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "sotalol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "MOXONIDINE may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "tizanidine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Remikiren", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Remikiren may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "Spirapril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "alprenolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "losartan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "losartan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "lisinopril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "captopril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "sotalol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Mirabegron", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Mirabegron.", "severity": 2}
{"drug1": "practolol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "labetalol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "benazepril", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Candesartan cilexetil may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "atenolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "practolol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "practolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "betaxolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "nadolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "practolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "cyclobenzaprine", "interaction_type": 37, "interaction_text": "GUANFACINE may decrease the antihypertensive activities of cyclobenzaprine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Sitaxsentan may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "nadolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "timolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "levonordefrin may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "acebutolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "oxymetazoline may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "trandolapril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Spirapril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "Spirapril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "tizanidine", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "tizanidine may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "Bethanidine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "phentolamine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "pergolide", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "acemetacin", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of acemetacin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "captopril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "captopril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "guanabenz", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "quinapril", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "carvedilol", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "fosinopril may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "epinephrine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "carvedilol", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "epinephrine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "epinephrine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "triamterene", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "labetalol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "mycophenolic acid", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of mycophenolic acid.", "severity": 2}
{"drug1": "alprenolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "labetalol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "practolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "atenolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "nadolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "alprenolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "betaxolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "practolol", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "labetalol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "trichlormethiazide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "droxidopa", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "droxidopa may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "sotalol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "nadolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Bretylium may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "propranolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "hydralazine", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "triamterene", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "cilazapril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "triamterene", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "pergolide", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "timolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "sotalol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Lornoxicam", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of Lornoxicam.", "severity": 2}
{"drug1": "brimonidine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "brimonidine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "triamterene", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "ramipril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "ramipril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "nimesulide", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of nimesulide.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "penbutolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "sotalol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "betaxolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "acebutolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "acebutolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "timolol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "resveratrol", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of resveratrol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Pentolinium may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Pimecrolimus", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of Pimecrolimus.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "labetalol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Travoprost may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "xylometazoline may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Olopatadine", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Olopatadine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ketoprofen", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of ketoprofen.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "AMILORIDE may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "lisinopril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "nortriptyline", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of nortriptyline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "amoxapine", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of amoxapine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "timolol", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "benzphetamine may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "hydralazine", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "BISOPROLOL may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "TRIMETHAPHAN may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "fenbufen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of fenbufen.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "antipyrine", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of antipyrine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "Bevantolol may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "quinapril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "quinapril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "diflunisal", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of diflunisal.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "chlorothiazide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "labetalol", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "meclofenamic acid", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of meclofenamic acid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "salicylamide", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of salicylamide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "Treprostinil may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "naphazoline", "drug2": "protriptyline", "interaction_type": 37, "interaction_text": "naphazoline may decrease the antihypertensive activities of protriptyline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "imipramine", "interaction_type": 37, "interaction_text": "apraclonidine may decrease the antihypertensive activities of imipramine.", "severity": 2}
{"drug1": "propranolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "trimipramine", "interaction_type": 37, "interaction_text": "METHAMPHETAMINE may decrease the antihypertensive activities of trimipramine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "leflunomide", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of leflunomide.", "severity": 2}
{"drug1": "labetalol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "propranolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "desipramine", "interaction_type": 37, "interaction_text": "DEXMEDETOMIDINE may decrease the antihypertensive activities of desipramine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "salicylic acid", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of salicylic acid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "enalapril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "enalapril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "sotalol", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Teriflunomide", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Teriflunomide.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "mefenamic acid", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of mefenamic acid.", "severity": 2}
{"drug1": "practolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "ESMOLOL may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "etodolac", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of etodolac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "tiaprofenic acid", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of tiaprofenic acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "practolol", "drug2": "sulfasalazine", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of sulfasalazine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Etomidate", "drug2": "amitriptyline", "interaction_type": 37, "interaction_text": "Etomidate may decrease the antihypertensive activities of amitriptyline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "LEVOBUNOLOL may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "betaxolol", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "betaxolol may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "alprenolol", "drug2": "diclofenac", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of diclofenac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Apremilast", "interaction_type": 37, "interaction_text": "Aliskiren may decrease the antihypertensive activities of Apremilast.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "Tianeptine", "interaction_type": 37, "interaction_text": "dipivefrin may decrease the antihypertensive activities of Tianeptine.", "severity": 2}
{"drug1": "atenolol", "drug2": "mycophenolate mofetil", "interaction_type": 37, "interaction_text": "atenolol may decrease the antihypertensive activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "Enalaprilat may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "manidipine", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "manidipine may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Icatibant", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Icatibant.", "severity": 2}
{"drug1": "pergolide", "drug2": "Dothiepin", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of Dothiepin.", "severity": 2}
{"drug1": "diazoxide", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "diazoxide may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ETOFENAMATE", "interaction_type": 37, "interaction_text": "metoprolol may decrease the antihypertensive activities of ETOFENAMATE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "mirtazapine", "interaction_type": 37, "interaction_text": "guanabenz may decrease the antihypertensive activities of mirtazapine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Etoricoxib", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Etoricoxib.", "severity": 2}
{"drug1": "cilazapril", "drug2": "mesalamine", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of mesalamine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "fenoprofen", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of fenoprofen.", "severity": 2}
{"drug1": "pergolide", "drug2": "doxepin", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of doxepin.", "severity": 2}
{"drug1": "practolol", "drug2": "Masoprocol", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of Masoprocol.", "severity": 2}
{"drug1": "practolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "practolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "benazepril", "drug2": "aspirin", "interaction_type": 37, "interaction_text": "benazepril may decrease the antihypertensive activities of aspirin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Naftifine", "interaction_type": 37, "interaction_text": "penbutolol may decrease the antihypertensive activities of Naftifine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "carprofen", "interaction_type": 37, "interaction_text": "spironolactone may decrease the antihypertensive activities of carprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "propranolol", "drug2": "Loxoprofen", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Loxoprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Droxicam", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of Droxicam.", "severity": 2}
{"drug1": "propranolol", "drug2": "tolfenamic acid", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "propranolol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "doxazosin", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "doxazosin may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "timolol", "drug2": "Olsalazine", "interaction_type": 37, "interaction_text": "timolol may decrease the antihypertensive activities of Olsalazine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "Eplerenone may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "PIRFENIDONE", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of PIRFENIDONE.", "severity": 2}
{"drug1": "pergolide", "drug2": "Levomilnacipran", "interaction_type": 37, "interaction_text": "pergolide may decrease the antihypertensive activities of Levomilnacipran.", "severity": 2}
{"drug1": "sotalol", "drug2": "flurbiprofen", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of flurbiprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "epirizole", "interaction_type": 37, "interaction_text": "Nebivolol may decrease the antihypertensive activities of epirizole.", "severity": 2}
{"drug1": "cilazapril", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "cilazapril may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tenoxicam", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of tenoxicam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "oxaprozin", "interaction_type": 37, "interaction_text": "CARTEOLOL may decrease the antihypertensive activities of oxaprozin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "sotalol", "drug2": "Lumiracoxib", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of Lumiracoxib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Magnesium salicylate", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Magnesium salicylate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ADAPALENE", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of ADAPALENE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "oxyphenbutazone", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of oxyphenbutazone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Salsalate", "interaction_type": 37, "interaction_text": "oxprenolol may decrease the antihypertensive activities of Salsalate.", "severity": 2}
{"drug1": "triamterene", "drug2": "BALSALAZIDE", "interaction_type": 37, "interaction_text": "triamterene may decrease the antihypertensive activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "BENZYDAMINE", "interaction_type": 37, "interaction_text": "Arotinolol may decrease the antihypertensive activities of BENZYDAMINE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "alclofenac", "interaction_type": 37, "interaction_text": "celiprolol may decrease the antihypertensive activities of alclofenac.", "severity": 2}
{"drug1": "alprenolol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "indomethacin", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of indomethacin.", "severity": 2}
{"drug1": "labetalol", "drug2": "azelastine", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of azelastine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "duloxetine", "interaction_type": 37, "interaction_text": "Paliperidone may decrease the antihypertensive activities of duloxetine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "ibuprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of ibuprofen.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "nabumetone", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of nabumetone.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ketorolac", "interaction_type": 37, "interaction_text": "BUPRANOLOL may decrease the antihypertensive activities of ketorolac.", "severity": 2}
{"drug1": "labetalol", "drug2": "NAPROXEN", "interaction_type": 37, "interaction_text": "labetalol may decrease the antihypertensive activities of NAPROXEN.", "severity": 2}
{"drug1": "hydralazine", "drug2": "tolmetin", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of tolmetin.", "severity": 2}
{"drug1": "nadolol", "drug2": "ZILEUTON", "interaction_type": 37, "interaction_text": "nadolol may decrease the antihypertensive activities of ZILEUTON.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Milnacipran", "interaction_type": 37, "interaction_text": "apomorphine may decrease the antihypertensive activities of Milnacipran.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "celecoxib", "interaction_type": 37, "interaction_text": "Metipranolol may decrease the antihypertensive activities of celecoxib.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Propacetamol", "interaction_type": 37, "interaction_text": "BOPINDOLOL may decrease the antihypertensive activities of Propacetamol.", "severity": 2}
{"drug1": "prazosin", "drug2": "Yohimbine", "interaction_type": 37, "interaction_text": "prazosin may decrease the antihypertensive activities of Yohimbine.", "severity": 2}
{"drug1": "sotalol", "drug2": "CLONIXIN", "interaction_type": 37, "interaction_text": "sotalol may decrease the antihypertensive activities of CLONIXIN.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Nepafenac", "interaction_type": 37, "interaction_text": "alprenolol may decrease the antihypertensive activities of Nepafenac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Aceclofenac", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of Aceclofenac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "zaltoprofen", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of zaltoprofen.", "severity": 2}
{"drug1": "hydralazine", "drug2": "suprofen", "interaction_type": 37, "interaction_text": "hydralazine may decrease the antihypertensive activities of suprofen.", "severity": 2}
{"drug1": "phentolamine", "drug2": "methylphenidate", "interaction_type": 37, "interaction_text": "phentolamine may decrease the antihypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "SERATRODAST", "interaction_type": 37, "interaction_text": "carvedilol may decrease the antihypertensive activities of SERATRODAST.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "ethanol", "interaction_type": 38, "interaction_text": "ISOSORBIDE DINITRATE may increase the vasodilatory activities of ethanol.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Avanafil", "interaction_type": 38, "interaction_text": "nitroglycerin may increase the vasodilatory activities of Avanafil.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "Avanafil", "interaction_type": 38, "interaction_text": "ERYTHRITYL TETRANITRATE may increase the vasodilatory activities of Avanafil.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Udenafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE DINITRATE may increase the vasodilatory activities of Udenafil.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Udenafil", "interaction_type": 38, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the vasodilatory activities of Udenafil.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "Tadalafil", "interaction_type": 38, "interaction_text": "ERYTHRITYL TETRANITRATE may increase the vasodilatory activities of Tadalafil.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Vardenafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE MONONITRATE may increase the vasodilatory activities of Vardenafil.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Udenafil", "interaction_type": 38, "interaction_text": "Pentyl nitrite may increase the vasodilatory activities of Udenafil.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Tadalafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE MONONITRATE may increase the vasodilatory activities of Tadalafil.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "Vardenafil", "interaction_type": 38, "interaction_text": "ERYTHRITYL TETRANITRATE may increase the vasodilatory activities of Vardenafil.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Vardenafil", "interaction_type": 38, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the vasodilatory activities of Vardenafil.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "Udenafil", "interaction_type": 38, "interaction_text": "ERYTHRITYL TETRANITRATE may increase the vasodilatory activities of Udenafil.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "sildenafil", "interaction_type": 38, "interaction_text": "Pentyl nitrite may increase the vasodilatory activities of sildenafil.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Avanafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE MONONITRATE may increase the vasodilatory activities of Avanafil.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Avanafil", "interaction_type": 38, "interaction_text": "Pentyl nitrite may increase the vasodilatory activities of Avanafil.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "sildenafil", "interaction_type": 38, "interaction_text": "nitroglycerin may increase the vasodilatory activities of sildenafil.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Avanafil", "interaction_type": 38, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the vasodilatory activities of Avanafil.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Vardenafil", "interaction_type": 38, "interaction_text": "Pentyl nitrite may increase the vasodilatory activities of Vardenafil.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Udenafil", "interaction_type": 38, "interaction_text": "nitroglycerin may increase the vasodilatory activities of Udenafil.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "ethanol", "interaction_type": 38, "interaction_text": "ISOSORBIDE MONONITRATE may increase the vasodilatory activities of ethanol.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "sildenafil", "interaction_type": 38, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the vasodilatory activities of sildenafil.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Tadalafil", "interaction_type": 38, "interaction_text": "nitroglycerin may increase the vasodilatory activities of Tadalafil.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Tadalafil", "interaction_type": 38, "interaction_text": "Pentyl nitrite may increase the vasodilatory activities of Tadalafil.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Vardenafil", "interaction_type": 38, "interaction_text": "nitroglycerin may increase the vasodilatory activities of Vardenafil.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Tadalafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE DINITRATE may increase the vasodilatory activities of Tadalafil.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Avanafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE DINITRATE may increase the vasodilatory activities of Avanafil.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "ethanol", "interaction_type": 38, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the vasodilatory activities of ethanol.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "ethanol", "interaction_type": 38, "interaction_text": "nitroglycerin may increase the vasodilatory activities of ethanol.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "sildenafil", "interaction_type": 38, "interaction_text": "ERYTHRITYL TETRANITRATE may increase the vasodilatory activities of sildenafil.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Vardenafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE DINITRATE may increase the vasodilatory activities of Vardenafil.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Tadalafil", "interaction_type": 38, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the vasodilatory activities of Tadalafil.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "ethanol", "interaction_type": 38, "interaction_text": "ERYTHRITYL TETRANITRATE may increase the vasodilatory activities of ethanol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Udenafil", "interaction_type": 38, "interaction_text": "ISOSORBIDE MONONITRATE may increase the vasodilatory activities of Udenafil.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Butylscopolamine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "REMIFENTANIL may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "meperidine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "meperidine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "TRIMETHAPHAN may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "pentazocine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "pancuronium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "nalbuphine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Methylscopolamine bromide may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "tropicamide may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "mecamylamine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "methadone", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "methadone may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "oxycodone may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "ANISOTROPINE METHYLBROMIDE may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "tubocurarine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Atracurium besylate may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Normethadone may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "orphenadrine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Aclidinium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "loperamide", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "loperamide may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "hydromorphone may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "DEZOCINE may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "oxyphenonium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "oxycodone may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "tolterodine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Vecuronium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "dicyclomine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Desloratadine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "cyclopentolate may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "HYDROCODONE may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "ALFENTANIL may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "propoxyphene may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "codeine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "codeine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "levorphanol may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "oxybutynin may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "propoxyphene may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Methylscopolamine bromide may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "oxybutynin may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "cyclopentolate may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "quinidine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "quinidine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "meperidine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "meperidine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "oxymorphone may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "buprenorphine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "REMIFENTANIL may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Metixene", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Metixene may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "ethopropazine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "biperiden", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "biperiden may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "propantheline", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "propantheline may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "hydromorphone may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Vecuronium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "quinidine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "quinidine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "orphenadrine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "oxyphenonium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Metixene", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Metixene may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "ethopropazine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "oxymorphone may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Ethylmorphine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "ipratropium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "SUFENTANIL may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Propiverine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "codeine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "codeine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Ketobemidone may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "pentazocine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "DEZOCINE may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "methscopolamine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Tiotropium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "ipratropium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Tramadol may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "buprenorphine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Trospium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Trospium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Fesoterodine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "scopolamine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "SUFENTANIL may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "hyoscyamine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "procyclidine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "benztropine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "benztropine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Normethadone may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Aclidinium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "levorphanol may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Atracurium besylate may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "butorphanol may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "biperiden", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "biperiden may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "ATROPINE may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "PIPECURONIUM may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "HEROIN may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "alosetron", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "alosetron may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Ethylmorphine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "DIHYDROCODEINE may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Propiverine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "UMECLIDINIUM may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "ATROPINE may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "butorphanol may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "dicyclomine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "ANISOTROPINE METHYLBROMIDE may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "trihexyphenidyl may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Glycopyrronium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "morphine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "morphine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "pirenzepine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "DIPHENOXYLATE may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Pentolinium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Methadyl acetate may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Pentolinium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "pirenzepine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Tramadol may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "mecamylamine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Ketobemidone may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "benztropine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "benztropine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Tiotropium may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "tubocurarine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Fesoterodine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "hyoscyamine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "HYDROCODONE may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "ALFENTANIL may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "pancuronium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "tropicamide may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "methscopolamine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Tapentadol may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "methadone", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "methadone may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "nalbuphine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "scopolamine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "TRIMETHAPHAN may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "DIHYDROCODEINE may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "trihexyphenidyl may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "procyclidine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "tolterodine may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "HEROIN may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Butylscopolamine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Tapentadol may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Desloratadine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "morphine", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "morphine may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Glycopyrronium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "DIPHENOXYLATE may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "PIPECURONIUM may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "propantheline", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "propantheline may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Ramosetron", "interaction_type": 39, "interaction_text": "Methadyl acetate may increase the constipating activities of Ramosetron.", "severity": 2}
{"drug1": "Trospium", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "Trospium may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Eluxadoline", "interaction_type": 39, "interaction_text": "UMECLIDINIUM may increase the constipating activities of Eluxadoline.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "pancuronium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Arbekacin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Arbekacin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "metrizamide", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of metrizamide.", "severity": 2}
{"drug1": "decamethonium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "PYRANTEL", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "PYRANTEL may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "succinylcholine may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "tobramycin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of tobramycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "pancuronium may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "Valrubicin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of Valrubicin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "doxorubicin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of doxorubicin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "streptozocin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of streptozocin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "ribostamycin", "interaction_type": 40, "interaction_text": "Vecuronium may increase the respiratory depressant activities of ribostamycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "paromomycin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of paromomycin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "Rocuronium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "Rocuronium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Spectinomycin", "interaction_type": 40, "interaction_text": "Atracurium besylate may increase the respiratory depressant activities of Spectinomycin.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "amikacin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of amikacin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "decamethonium may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "IDARUBICIN", "interaction_type": 40, "interaction_text": "tubocurarine may increase the respiratory depressant activities of IDARUBICIN.", "severity": 2}
{"drug1": "Cisatracurium", "drug2": "Amrubicin", "interaction_type": 40, "interaction_text": "Cisatracurium may increase the respiratory depressant activities of Amrubicin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "netilmicin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of netilmicin.", "severity": 2}
{"drug1": "Mivacurium", "drug2": "Epirubicin", "interaction_type": 40, "interaction_text": "Mivacurium may increase the respiratory depressant activities of Epirubicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "gentamicin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of gentamicin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "kanamycin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of kanamycin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "plicamycin", "interaction_type": 40, "interaction_text": "PIPECURONIUM may increase the respiratory depressant activities of plicamycin.", "severity": 2}
{"drug1": "Doxacurium", "drug2": "daunorubicin", "interaction_type": 40, "interaction_text": "Doxacurium may increase the respiratory depressant activities of daunorubicin.", "severity": 2}
{"drug1": "METOCURINE", "drug2": "streptomycin", "interaction_type": 40, "interaction_text": "METOCURINE may increase the respiratory depressant activities of streptomycin.", "severity": 2}
{"drug1": "methylene blue", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "methylene blue may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "selegiline", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "selegiline may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "tranylcypromine may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "Phenelzine", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "Phenelzine may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "Pirlindole", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "Pirlindole may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "furazolidone", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "furazolidone may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "rasagiline", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "rasagiline may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "isocarboxazid", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "isocarboxazid may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "AMPHETAMINE", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "AMPHETAMINE may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "procarbazine", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "procarbazine may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "Toloxatone", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "Toloxatone may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "pargyline", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "pargyline may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "moclobemide", "drug2": "meperidine", "interaction_type": 41, "interaction_text": "moclobemide may increase the hypotensive and central nervous system depressant (CNS depressant) activities of meperidine.", "severity": 3}
{"drug1": "spironolactone", "drug2": "cyclosporin A", "interaction_type": 42, "interaction_text": "The risk or severity of hyperkalemia can be increased when spironolactone is combined with cyclosporin A.", "severity": 2}
{"drug1": "triamterene", "drug2": "tacrolimus", "interaction_type": 42, "interaction_text": "The risk or severity of hyperkalemia can be increased when triamterene is combined with tacrolimus.", "severity": 2}
{"drug1": "spironolactone", "drug2": "tacrolimus", "interaction_type": 42, "interaction_text": "The risk or severity of hyperkalemia can be increased when spironolactone is combined with tacrolimus.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "tacrolimus", "interaction_type": 42, "interaction_text": "The risk or severity of hyperkalemia can be increased when AMILORIDE is combined with tacrolimus.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "cyclosporin A", "interaction_type": 42, "interaction_text": "The risk or severity of hyperkalemia can be increased when AMILORIDE is combined with cyclosporin A.", "severity": 2}
{"drug1": "triamterene", "drug2": "cyclosporin A", "interaction_type": 42, "interaction_text": "The risk or severity of hyperkalemia can be increased when triamterene is combined with cyclosporin A.", "severity": 2}
{"drug1": "glipizide", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cefazolin", "interaction_type": 43, "interaction_text": "The protein binding of cefazolin can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with tolazamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cefazolin", "interaction_type": 43, "interaction_text": "The protein binding of cefazolin can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "glyburide", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with Gliquidone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "probenecid", "interaction_type": 43, "interaction_text": "The protein binding of probenecid can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "Toloxatone may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "rasagiline", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "rasagiline may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "tranylcypromine", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "tranylcypromine may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "pargyline", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "pargyline may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "moclobemide", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "moclobemide may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "Phenelzine", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "Phenelzine may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "isocarboxazid", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "isocarboxazid may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "Pirlindole", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "Pirlindole may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "selegiline", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "selegiline may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "procarbazine", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "procarbazine may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "furazolidone", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "furazolidone may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "methylene blue", "drug2": "Atomoxetine", "interaction_type": 44, "interaction_text": "methylene blue may increase the central neurotoxic activities of Atomoxetine.", "severity": 3}
{"drug1": "123I-Ioflupane", "drug2": "citalopram", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of citalopram as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "Escitalopram", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of Escitalopram as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "selegiline", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of selegiline as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "Milnacipran", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of Milnacipran as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "bupropion", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of bupropion as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "cocaine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of cocaine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "MEPHENTERMINE", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of MEPHENTERMINE as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "nefazodone", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of nefazodone as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "fluoxetine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of fluoxetine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "duloxetine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of duloxetine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "norepinephrine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of norepinephrine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "dextroamphetamine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of dextroamphetamine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "METHAMPHETAMINE", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of METHAMPHETAMINE as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "paroxetine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of paroxetine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "fluvoxamine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of fluvoxamine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "benztropine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of benztropine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "buspirone", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of buspirone as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "sertraline", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of sertraline as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "Amfepramone", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of Amfepramone as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "Levomilnacipran", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of Levomilnacipran as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "hydroxyamphetamine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of hydroxyamphetamine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "venlafaxine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of venlafaxine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "phenylephrine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of phenylephrine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of PSEUDOEPHEDRINE as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "Lisdexamfetamine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of Lisdexamfetamine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "methylphenidate", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of methylphenidate as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "AMPHETAMINE", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of AMPHETAMINE as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "amoxapine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of amoxapine as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "Dexmethylphenidate", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of Dexmethylphenidate as a diagnostic agent.", "severity": 2}
{"drug1": "123I-Ioflupane", "drug2": "benzphetamine", "interaction_type": 45, "interaction_text": "123I-Ioflupane may decrease effectiveness of benzphetamine as a diagnostic agent.", "severity": 2}
{"drug1": "penbutolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "penbutolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "timolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "timolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "metoprolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "Bevantolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "Arotinolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "alprenolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "Nebivolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "ESMOLOL may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "LEVOBUNOLOL may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "oxprenolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "labetalol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "labetalol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "practolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "practolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "CARTEOLOL may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "carvedilol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "acebutolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "BISOPROLOL may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "nadolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "nadolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "BUPRANOLOL may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "betaxolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "propranolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "propranolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "Metipranolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "BOPINDOLOL may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "atenolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "atenolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "sotalol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "sotalol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "methacholine", "interaction_type": 46, "interaction_text": "celiprolol may increase the bronchoconstrictory activities of methacholine.", "severity": 2}
{"drug1": "albendazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "felodipine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "proguanil", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "isradipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "propranolol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "propranolol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "buspirone", "drug2": "CICLOPIROX", "interaction_type": 47, "interaction_text": "The metabolism of CICLOPIROX can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "propranolol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "cisapride", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "desipramine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "clofibrate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "diazepam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Amrinone", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Amrinone.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Palbociclib.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Palbociclib.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Encainide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "dolasetron", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "epinastine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "pravastatin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "primidone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with primidone.", "severity": 2}
{"drug1": "spiramycin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "montelukast", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "levodopa", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "levodopa", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "theophylline", "drug2": "cinoxacin", "interaction_type": 47, "interaction_text": "The metabolism of cinoxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "albendazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Encainide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Encainide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "riluzole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "erythromycin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Encainide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Encainide", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "sertraline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "estramustine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Quinine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "prednisone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "imipramine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "clozapine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "promazine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with promazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "mianserin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "clonidine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "bromazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "omeprazole", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "tinidazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "argatroban", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "theophylline", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "miconazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "ajmaline", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "diltiazem", "drug2": "MOEXIPRIL", "interaction_type": 47, "interaction_text": "The metabolism of MOEXIPRIL can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "progesterone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "nevirapine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "digoxin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "digoxin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "domperidone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "prazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "halothane", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "glyburide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "pentamidine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "guanabenz", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "moclobemide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "dopamine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "ethanol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "estradiol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "glucosamine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "estradiol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "astemizole", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nimesulide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "dopamine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "halothane", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with halothane.", "severity": 2}
{"drug1": "apomorphine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "teniposide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "bepridil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "flutamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "benztropine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Letermovir", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Letermovir", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "amiodarone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "nilutamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "halothane", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "mestranol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "caffeine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "nateglinide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "propranolol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "alosetron", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "lomustine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "lomustine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "sertraline", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "morphine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with morphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "clorazepate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "losartan", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "quinidine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "flutamide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "clonidine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "propranolol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "piperazine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "doxepin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "etizolam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "doxepin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "theobromine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "formoterol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Risedronic acid.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "methadone", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with methadone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "propafenone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with propafenone.", "severity": 2}
{"drug1": "thiotepa", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "buspirone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "testosterone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "formoterol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "estramustine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "isradipine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "testosterone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "modafinil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "modafinil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "buspirone", "drug2": "haloprogin", "interaction_type": 47, "interaction_text": "The metabolism of haloprogin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "busulfan", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "morphine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "cisapride", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "benztropine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "paroxetine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "formoterol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Quinine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "levodopa", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "ketamine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "metronidazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "modafinil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "metronidazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "modafinil", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "metronidazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "cocaine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "progesterone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "etoposide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ximelagatran", "interaction_type": 47, "interaction_text": "The metabolism of Ximelagatran can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Safinamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Milnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Milnacipran can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "montelukast", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "nicardipine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "AMPHETAMINE", "interaction_type": 47, "interaction_text": "The metabolism of AMPHETAMINE can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "prazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "spiramycin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "theobromine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "naloxone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "prazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "prazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "menadione", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with menadione.", "severity": 2}
{"drug1": "celecoxib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "amsacrine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "bepridil", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "ranitidine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "domperidone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "mefloquine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "azelastine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "glucosamine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "vinblastine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "norethindrone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "donepezil", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "halothane", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "warfarin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "glipizide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "theophylline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "glipizide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "theophylline", "drug2": "Pefloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Pefloxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "triazolam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "losartan", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "halothane", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Encainide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "histamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "temazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "ketamine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "dopamine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "indapamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "indapamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "progesterone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "estradiol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with penbutolol.", "severity": 2}
{"drug1": "praziquantel", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "triazolam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "histamine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "alclometasone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "proguanil", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "piperazine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "testosterone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "riluzole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "flurazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "halothane", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with halothane.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Enalaprilat", "interaction_type": 47, "interaction_text": "The metabolism of Enalaprilat can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "progesterone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "progesterone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "timolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Sitagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Sitagliptin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "diclofenac", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "propranolol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "miconazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "benztropine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "miconazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "miconazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "nicotine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with gabapentin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "morphine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "flutamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "famciclovir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "famotidine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "clofibrate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "temazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with mitoxantrone.", "severity": 2}
{"drug1": "montelukast", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "cisapride", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "dyphylline", "drug2": "enoxacin", "interaction_type": 47, "interaction_text": "The metabolism of enoxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "nicotine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "nicotine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "epinastine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "epinastine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Isoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Isoconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "gliclazide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "miconazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "meperidine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "tazarotene", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "cisapride", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "isradipine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "cephalexin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "spiramycin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "granisetron", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "docetaxel", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Melatonin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Quinine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "loratadine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "cilazapril", "interaction_type": 47, "interaction_text": "The metabolism of cilazapril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Spirapril", "interaction_type": 47, "interaction_text": "The metabolism of Spirapril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "caffeine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "buspirone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "perphenazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "clonidine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "losartan", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "losartan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "benzoic acid", "interaction_type": 47, "interaction_text": "The metabolism of benzoic acid can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "dolasetron", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "dolasetron", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "busulfan", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "testosterone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ajmaline", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "meperidine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "benztropine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "astemizole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "thiotepa", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "loratadine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "mianserin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "mestranol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "norgestrel", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "propofol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "clofazimine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "clofazimine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "caffeine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "carmustine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "temazepam", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "progesterone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "aspirin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "vincristine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "vincristine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "vincristine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Macitentan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "loperamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Milnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Milnacipran can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "THYMOL", "interaction_type": 47, "interaction_text": "The metabolism of THYMOL can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Artemether", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Letermovir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "nilutamide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "glyburide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "morphine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "benztropine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "benztropine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "argatroban", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "miconazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "teniposide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "clozapine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "mianserin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "dopamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "formoterol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "buspirone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "buspirone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "risperidone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "propranolol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "raloxifene", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "methyprylon", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "nifedipine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "cisapride", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "modafinil", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "glipizide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "famotidine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "loratadine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Apixaban", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "flecainide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "zolpidem", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "perphenazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Apremilast", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "testosterone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "formoterol", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "formoterol", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "etodolac", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "tolterodine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "methyprylon", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "desipramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "enflurane", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with enflurane.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "metronidazole", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "desipramine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Artemether", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "metronidazole", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "tiagabine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "prazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "loratadine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "dolasetron", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "montelukast", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "timolol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with timolol.", "severity": 2}
{"drug1": "timolol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "naloxone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "alosetron", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "naloxone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "fosinopril", "interaction_type": 47, "interaction_text": "The metabolism of fosinopril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "toremifene", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "proguanil", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "buspirone", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "nicotine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "methadone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with methadone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "flutamide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "mequitazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with nimesulide.", "severity": 2}
{"drug1": "Encainide", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "montelukast", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "timolol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "argatroban", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "argatroban", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "lomustine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "propranolol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "teniposide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "tetracycline", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "mebendazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "granisetron", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "bupropion", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "bupropion", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "bupropion", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Macitentan", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "omeprazole", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "donepezil", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "omeprazole", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "terbinafine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "buspirone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "amsacrine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "nicotine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "aspirin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "aspirin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "etoposide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "flutamide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "etoposide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clonidine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "riluzole", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "docetaxel", "drug2": "salicylic acid", "interaction_type": 47, "interaction_text": "The metabolism of salicylic acid can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "estrone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "ambroxol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "morphine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "citalopram", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "flurazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "guanabenz", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "flurazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Netupitant", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "guanabenz", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "dopamine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "cocaine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "clozapine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "etoposide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "bepridil", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "sibutramine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "dopamine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Asenapine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "tolterodine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "suprofen", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Metipranolol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "astemizole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "docetaxel", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "docetaxel", "drug2": "terconazole", "interaction_type": 47, "interaction_text": "The metabolism of terconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "prednisone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "letrozole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "risperidone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "etodolac", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "amoxapine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "methyprylon", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "progesterone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "galanthamine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Gatifloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Gatifloxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "warfarin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "digitoxin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "timolol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "alosetron", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "benazepril", "interaction_type": 47, "interaction_text": "The metabolism of benazepril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "vincristine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "halothane", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "doxepin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "nicotine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "loperamide", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "theophylline", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "theophylline", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Artemether", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Artemether", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "flutamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "glipizide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "flutamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "propafenone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with propafenone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "folic acid", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with folic acid.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "formoterol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "glyburide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "glyburide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "progesterone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "4-aminopyridine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with 4-aminopyridine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "pergolide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "cisapride", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "sertraline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "pergolide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "diazepam", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "methadone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "calcitriol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "famotidine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "piperazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "clonazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "etodolac", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "dapsone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "glipizide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "montelukast", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "caffeine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "cisapride", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "meperidine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "meperidine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "dolasetron", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "dolasetron", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "epinastine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "bupropion", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "propafenone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with propafenone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "sildenafil", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "estrone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with estrone.", "severity": 2}
{"drug1": "levodopa", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "finasteride", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "celecoxib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "trandolapril", "interaction_type": 47, "interaction_text": "The metabolism of trandolapril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "spiramycin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "meprobamate", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "disulfiram", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "ethanol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "aspirin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "nicotine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "busulfan", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "doxepin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "prednisone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "loratadine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "amprenavir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "tinidazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "tinidazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "azelastine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "aspirin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "clonidine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "aspirin", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "estrone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with estrone.", "severity": 2}
{"drug1": "theophylline", "drug2": "sparfloxacin", "interaction_type": 47, "interaction_text": "The metabolism of sparfloxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "donepezil", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "promethazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "rapamycin", "interaction_type": 47, "interaction_text": "The metabolism of rapamycin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "flecainide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "testosterone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "glimepiride", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "nicardipine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "ethanol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "dapsone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "etizolam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "tolazamide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with tolazamide.", "severity": 2}
{"drug1": "estradiol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "cocaine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "clofibrate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "zidovudine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "prazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Perampanel", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "astemizole", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "risperidone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "risperidone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "irinotecan", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "letrozole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "benztropine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "alosetron", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "benztropine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "dopamine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "loperamide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "warfarin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "prednisone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "caffeine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "oxiconazole", "interaction_type": 47, "interaction_text": "The metabolism of oxiconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "letrozole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "propranolol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "meperidine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "glipizide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "labetalol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "etoposide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "guanabenz", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "quinidine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "propranolol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Safinamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "zaleplon", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "zaleplon", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Imatinib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "duloxetine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "imipramine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "pergolide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "proguanil", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Milnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Milnacipran can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "felbamate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "zidovudine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "felbamate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Tavaborole", "interaction_type": 47, "interaction_text": "The metabolism of Tavaborole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "EFINACONAZOLE", "interaction_type": 47, "interaction_text": "The metabolism of EFINACONAZOLE can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "nicotine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "montelukast", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "histamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "midazolam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "amsacrine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "teniposide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "morphine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "suprofen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "diazepam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "isradipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "halothane", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "theophylline", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "halothane", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with halothane.", "severity": 2}
{"drug1": "isradipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "propranolol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "suprofen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "captopril", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with captopril.", "severity": 2}
{"drug1": "morphine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "etodolac", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "loratadine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "quazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "benztropine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "clonidine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "teniposide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Pinaverium.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "promethazine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "amprenavir", "interaction_type": 47, "interaction_text": "The metabolism of amprenavir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Capsaicin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Capsaicin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "triamterene", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "etoposide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "gliclazide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "docetaxel", "drug2": "amphotericin b", "interaction_type": 47, "interaction_text": "The metabolism of amphotericin b can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "ajmaline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Encainide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "ketamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "methadone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with methadone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "menadione", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with menadione.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "propranolol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "etoposide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Melatonin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "loperamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "donepezil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Gatifloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Gatifloxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "vincristine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "vincristine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "bepridil", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "aspirin", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "cytarabine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "quinidine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "tazarotene", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "estrone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "halothane", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "testosterone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "malathion", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "mianserin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "dopamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "dopamine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "promethazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "quinidine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "promethazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "caffeine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "alclometasone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "propofol", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with propofol.", "severity": 2}
{"drug1": "albendazole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "alclometasone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "azithromycin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "histamine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "glyburide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "nicotine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "ropinirole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "domperidone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "nilutamide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "benztropine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "etodolac", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "metronidazole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "progesterone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "amprenavir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "antipyrine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "ranitidine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "loperamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "letrozole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "moclobemide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "letrozole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "desipramine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "desipramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "moclobemide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "methadone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with methadone.", "severity": 2}
{"drug1": "dopamine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "diltiazem", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "isradipine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "raloxifene", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "celecoxib", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "loperamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Silodosin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Artemether", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "dolasetron", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "montelukast", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "levodopa", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "temazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "indomethacin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "granisetron", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "selegiline", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "mequitazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "flutamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "clozapine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "trazodone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "trazodone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "formoterol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "montelukast", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "niclosamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "loratadine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "nefazodone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "theophylline", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "malathion", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with malathion.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "felodipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "selegiline", "interaction_type": 47, "interaction_text": "The metabolism of selegiline can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "caffeine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Sertaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Sertaconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "diazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "sertraline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "haloperidol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "flurazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "zaleplon", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "benztropine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "mianserin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "ambroxol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Netupitant", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "irinotecan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "irinotecan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "triamterene", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "levodopa", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Encainide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "donepezil", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "dopamine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Asenapine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "flunarizine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "tolterodine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "progesterone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "glucosamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "propofol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Axitinib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "letrozole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "losartan", "drug2": "NATAMYCIN", "interaction_type": 47, "interaction_text": "The metabolism of NATAMYCIN can be decreased when combined with losartan.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "sertraline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "theophylline", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "timolol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with timolol.", "severity": 2}
{"drug1": "buspirone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Macitentan", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "simvastatin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "suprofen", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "caffeine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "losartan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "ipratropium", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "nilutamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "norethindrone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "clonidine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "norethindrone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "famciclovir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "glipizide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "labetalol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "quinidine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "quinidine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "flunarizine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "praziquantel", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "proguanil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "suprofen", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Permethrin", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "ketamine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Permethrin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Safinamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Safinamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "mianserin", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "indomethacin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "piperazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "flutamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "clonazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "tretinoin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "buspirone", "drug2": "Miltefosine", "interaction_type": 47, "interaction_text": "The metabolism of Miltefosine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "alprazolam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "ketamine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cocaine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "metronidazole", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "quinidine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "epinastine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "meperidine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "losartan", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "lomustine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Artemether", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "amsacrine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "propofol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "estramustine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Neratinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "alosetron", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "tiagabine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "temazepam", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "famotidine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "thalidomide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "epinastine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "mianserin", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "tinidazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "levodopa", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "estramustine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Artemether", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Encainide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "glimepiride", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "busulfan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Melatonin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "busulfan", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "perphenazine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Levomilnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Levomilnacipran can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "mianserin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "estrone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with estrone.", "severity": 2}
{"drug1": "loratadine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "suprofen", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "warfarin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "granisetron", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ecabet", "interaction_type": 47, "interaction_text": "The metabolism of Ecabet can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "sertraline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "progesterone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Netupitant", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "risperidone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "epinastine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Perampanel", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Perampanel", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Benidipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Benidipine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "risperidone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "chloroxine", "interaction_type": 47, "interaction_text": "The metabolism of chloroxine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "trazodone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "naloxone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "nicotine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Axitinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "enalapril", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "malathion", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with malathion.", "severity": 2}
{"drug1": "modafinil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "estradiol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "propofol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with propofol.", "severity": 2}
{"drug1": "doxepin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "glyburide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "azelastine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with xylometazoline.", "severity": 2}
{"drug1": "progesterone", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "progesterone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "warfarin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with ESMOLOL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "propofol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with propofol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "Artemether", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Benidipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Benidipine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "ondansetron", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sertraline", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "vincristine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Artemether", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "valsartan", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "ipratropium", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with atorvastatin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "selegiline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "doxepin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Letermovir", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "temazepam", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "citalopram", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "citalopram", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "propranolol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "granisetron", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "diazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Macitentan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "selegiline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "cisapride", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "quinacrine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "mianserin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "temazepam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "piperazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "riluzole", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Artemether", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "dopamine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "progesterone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "nicotine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "bromazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "terbinafine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "isradipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "spiramycin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "halothane", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "timolol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with timolol.", "severity": 2}
{"drug1": "timolol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with timolol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "alprazolam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "desipramine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "meperidine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "halothane", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "dapsone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dapsone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "captopril", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "loratadine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "thiotepa", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "morphine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "montelukast", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "terconazole", "interaction_type": 47, "interaction_text": "The metabolism of terconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "loratadine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "etoposide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "loratadine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "levodopa", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "captopril", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "captopril", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "captopril", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "progesterone", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Miltefosine", "interaction_type": 47, "interaction_text": "The metabolism of Miltefosine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "toremifene", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "disulfiram", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "argatroban", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "epinastine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "proguanil", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ambroxol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "theobromine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "donepezil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "ethanol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "zonisamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "zonisamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "methadone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with methadone.", "severity": 2}
{"drug1": "azelastine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "methadone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with methadone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "vinblastine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "halothane", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with halothane.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "theophylline", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "flecainide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "suprofen", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "levodopa", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "lidocaine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "digoxin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "digoxin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "labetalol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "tolperisone", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "vincristine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "testosterone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "celiprolol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "etizolam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "citalopram", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "triazolam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "promazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "irinotecan", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "testosterone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "dopamine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "timolol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with timolol.", "severity": 2}
{"drug1": "proguanil", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "sertraline", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "mestranol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "etodolac", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "etodolac", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "caffeine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "caffeine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sertraline", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "morphine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "donepezil", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "estrone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with estrone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "astemizole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "caffeine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "doxepin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "meperidine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "norgestrel", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "norgestrel", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "diclofenac", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "ipratropium", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "ipratropium", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "warfarin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "alosetron", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "alosetron", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "alosetron", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "alosetron", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "Letermovir", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "mianserin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "glipizide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "doxepin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "risperidone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "nicotine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "calcitriol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "thioridazine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "albendazole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "albendazole", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "zidovudine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "felbamate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "albendazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "azelastine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "piperazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "piperazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "piperazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "nicotine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "cytarabine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "diazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Quinine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "albendazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "propranolol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "propranolol", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Artemether", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "cisapride", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Melatonin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Melatonin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "acebutolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with acebutolol.", "severity": 2}
{"drug1": "diazepam", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Quinine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "Quinine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "diazepam", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "clindamycin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "naloxone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "naloxone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "naloxone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "testosterone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "teniposide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "chloroquine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "calcitriol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "spiramycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "estramustine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Encainide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "thalidomide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Perospirone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "formoterol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "caffeine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "azelastine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "halothane", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "theophylline", "drug2": "nalidixic acid", "interaction_type": 47, "interaction_text": "The metabolism of nalidixic acid can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "bepridil", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "testosterone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "menadione", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with menadione.", "severity": 2}
{"drug1": "menadione", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with menadione.", "severity": 2}
{"drug1": "menadione", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with menadione.", "severity": 2}
{"drug1": "aspirin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "clonidine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "naloxone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "ajmaline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "haloperidol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "chloroquine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "argatroban", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "clonazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "mianserin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Cilastatin", "interaction_type": 47, "interaction_text": "The metabolism of Cilastatin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "mianserin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "etizolam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "promethazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "theophylline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "felbamate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "felbamate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "quazepam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with METHOHEXITAL.", "severity": 2}
{"drug1": "felbamate", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "estradiol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "praziquantel", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "praziquantel", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "glyburide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "etizolam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "bepridil", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "bepridil", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "azelastine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "citalopram", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "progesterone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "amprenavir", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "cocaine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "cocaine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "desipramine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "ambroxol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "promazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "histamine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "warfarin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "loperamide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "sertraline", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "caffeine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "prazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "benazepril", "interaction_type": 47, "interaction_text": "The metabolism of benazepril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "loratadine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with propofol.", "severity": 2}
{"drug1": "temazepam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "indapamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "lomustine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "loperamide", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "zopiclone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "argatroban", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "ondansetron", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "theobromine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "temazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "toremifene", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "quazepam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "alprenolol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "cisapride", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "quazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "famotidine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "piperazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "donepezil", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "proguanil", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Riociguat", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "bupropion", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "estramustine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "vinblastine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "diazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "modafinil", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Imatinib", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "morphine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with morphine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "azelastine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "losartan", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "alprazolam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "benztropine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "flecainide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "progesterone", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "triamterene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Encainide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "estrone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "mequitazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "warfarin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "clonidine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "naloxone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "trazodone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "propranolol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "CICLOPIROX", "interaction_type": 47, "interaction_text": "The metabolism of CICLOPIROX can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "clonidine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "azelastine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "trazodone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "citalopram", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "aspirin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "glipizide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "estramustine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "zidovudine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "argatroban", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "albendazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "riluzole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "glyburide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "glyburide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "bepridil", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "temazepam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "temazepam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "aminophylline", "drug2": "fleroxacin", "interaction_type": 47, "interaction_text": "The metabolism of fleroxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "quinacrine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "meperidine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "dopamine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "ketamine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "citalopram", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "zolpidem", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "meperidine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "mestranol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dapsone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "alosetron", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "dapsone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "progesterone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "progesterone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "epinastine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "desipramine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "timolol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with timolol.", "severity": 2}
{"drug1": "finasteride", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "loperamide", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "trimipramine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "naloxone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "captopril", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "norgestrel", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "flutamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "tiagabine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "modafinil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "temazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "cisapride", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with halothane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "clozapine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "ambroxol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "methadone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with methadone.", "severity": 2}
{"drug1": "flutamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "flutamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "teniposide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "formoterol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "bupropion", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "bepridil", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Sertaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Sertaconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "trimetrexate", "interaction_type": 47, "interaction_text": "The metabolism of trimetrexate can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with BOPINDOLOL.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "promazine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with promazine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "mifepristone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mifepristone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with mifepristone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "niclosamide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "diazepam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "labetalol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Benidipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Benidipine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "digitoxin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "losartan", "drug2": "oxiconazole", "interaction_type": 47, "interaction_text": "The metabolism of oxiconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "theophylline", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "losartan", "drug2": "CICLOPIROX", "interaction_type": 47, "interaction_text": "The metabolism of CICLOPIROX can be decreased when combined with losartan.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "cytarabine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "losartan", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "vinblastine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "ethanol", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "ethanol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "miconazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "digoxin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Dienogest", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "domperidone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "testosterone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "trazodone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Axitinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "sertraline", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Neratinib", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "azelastine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "leflunomide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Anidulafungin", "interaction_type": 47, "interaction_text": "The metabolism of Anidulafungin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "leflunomide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "naloxone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "domperidone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "cisapride", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "norgestrel", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "norgestrel", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "losartan", "drug2": "THYMOL", "interaction_type": 47, "interaction_text": "The metabolism of THYMOL can be decreased when combined with losartan.", "severity": 2}
{"drug1": "timolol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "propofol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with propofol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "haloprogin", "interaction_type": 47, "interaction_text": "The metabolism of haloprogin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "sibutramine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "mianserin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "amprenavir", "interaction_type": 47, "interaction_text": "The metabolism of amprenavir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "alosetron", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "alosetron", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "alosetron", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "alosetron", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "alosetron", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "indapamide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "theophylline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "captopril", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "ipratropium", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "olanzapine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "Artemether", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "chloroquine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "oxazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "valsartan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "valsartan", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Asenapine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "doxepin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "pergolide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "temazepam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "amsacrine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "glipizide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "montelukast", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Artemether", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "mianserin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "captopril", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "piperazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "piperazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "piperazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "proguanil", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "modafinil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "methadone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with methadone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "promazine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "diazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "felodipine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Quinine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "formoterol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "meperidine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "tretinoin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "naloxone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "naloxone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with naratriptan.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with naratriptan.", "severity": 2}
{"drug1": "naratriptan", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with naratriptan.", "severity": 2}
{"drug1": "desipramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "halothane", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "finasteride", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "finasteride", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "methadone", "drug2": "Milnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Milnacipran can be decreased when combined with methadone.", "severity": 2}
{"drug1": "piperazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "toremifene", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "busulfan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Perospirone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "astemizole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "doxazosin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "nicotine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "argatroban", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "clindamycin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "mequitazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "trazodone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Quinine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "famotidine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "olanzapine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "flunarizine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "promazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "methadone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "proguanil", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "menadione", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with menadione.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Quinine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "naloxone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "paramethasone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "clozapine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Darunavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "dapsone", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "etoposide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "estrone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with estrone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "mefloquine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Melatonin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "digoxin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clonidine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "miconazole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "rasagiline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "flecainide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "domperidone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "losartan", "drug2": "sulconazole", "interaction_type": 47, "interaction_text": "The metabolism of sulconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "citalopram", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Permethrin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "moclobemide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "cephalexin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "propofol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with propofol.", "severity": 2}
{"drug1": "epinastine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "imipramine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "dopamine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "bepridil", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "timolol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "metronidazole", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "benztropine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "letrozole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "halothane", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with halothane.", "severity": 2}
{"drug1": "buspirone", "drug2": "amphotericin b", "interaction_type": 47, "interaction_text": "The metabolism of amphotericin b can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "metronidazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "betaxolol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "caffeine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "formoterol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "sertraline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "desipramine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "prednisone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "caffeine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "raloxifene", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "benztropine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "halothane", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with halothane.", "severity": 2}
{"drug1": "warfarin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "methyprylon", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "sertraline", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "mianserin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Letermovir", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Letermovir", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "glipizide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "codeine", "drug2": "Vapreotide", "interaction_type": 47, "interaction_text": "The metabolism of Vapreotide can be decreased when combined with codeine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Macitentan", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "clozapine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ketamine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "ketamine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "morphine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "morphine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Riociguat", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "methadone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "pergolide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Phenelzine", "interaction_type": 47, "interaction_text": "The metabolism of Phenelzine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "doxepin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "histamine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "zidovudine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "histamine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "histamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "piperazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "4-aminopyridine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with 4-aminopyridine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "dapsone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "nifedipine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "zopiclone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "celecoxib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "captopril", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "quazepam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "cisapride", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "losartan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with losartan.", "severity": 2}
{"drug1": "terbinafine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "azelastine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "finasteride", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "terbinafine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "methadone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Quinine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Quinine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "loratadine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "meperidine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "promazine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with promazine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "granisetron", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "clozapine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "clofibrate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "quetiapine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Linagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Linagliptin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "ketamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "cocaine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "promazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with promazine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "imipramine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Riociguat", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "prazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Cilastatin", "interaction_type": 47, "interaction_text": "The metabolism of Cilastatin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "etoposide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "imipramine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "diazepam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Isoflurophate", "interaction_type": 47, "interaction_text": "The metabolism of Isoflurophate can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "flunisolide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "disulfiram", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "quazepam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Naftifine", "interaction_type": 47, "interaction_text": "The metabolism of Naftifine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "pentamidine", "interaction_type": 47, "interaction_text": "The metabolism of pentamidine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "domperidone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "domperidone", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "imipramine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "granisetron", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "donepezil", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "omeprazole", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with oxprenolol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "amsacrine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "methadone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with methadone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "pergolide", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "progesterone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "theophylline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "donepezil", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "azelastine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "testosterone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "azelastine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "aspirin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "clonidine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "promazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "quinidine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "promazine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with promazine.", "severity": 2}
{"drug1": "promazine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "glyburide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "finasteride", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "haloperidol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "theophylline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "warfarin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "aminophylline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "testosterone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "testosterone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "losartan", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "clonidine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "progesterone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "estradiol", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "estradiol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "felodipine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "piperazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "halothane", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "argatroban", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "nilutamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "bepridil", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "testosterone", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "sertraline", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sertraline", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "estradiol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "testosterone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "nilutamide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "flutamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "halothane", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with halothane.", "severity": 2}
{"drug1": "propranolol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "toremifene", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "propranolol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "losartan", "drug2": "Sertaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Sertaconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "losartan", "drug2": "trimetrexate", "interaction_type": 47, "interaction_text": "The metabolism of trimetrexate can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "proguanil", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "betaxolol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "miconazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "nateglinide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "enalapril", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "warfarin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "glipizide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "warfarin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "meperidine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "loperamide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "bepridil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "warfarin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "losartan", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "valsartan", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "ipratropium", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "temazepam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "alosetron", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "alosetron", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "rapamycin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "etoposide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "nicotine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "histamine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with histamine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "zaleplon", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "famciclovir", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "duloxetine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "epinastine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "formoterol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "temazepam", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "antipyrine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Azelnidipine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "perphenazine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "timolol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "tazarotene", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "famotidine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "proguanil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Darunavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "glimepiride", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "glimepiride", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "glimepiride", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "doxazosin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "zolpidem", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "selegiline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "cisapride", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "formoterol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "formoterol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "dantrolene", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Vilazodone", "interaction_type": 47, "interaction_text": "The metabolism of Vilazodone can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "omeprazole", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "propranolol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "nicotine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "diazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Apremilast", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "oxiconazole", "interaction_type": 47, "interaction_text": "The metabolism of oxiconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Apremilast", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "midazolam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "diazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "diazepam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "estrone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with estrone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "buspirone", "drug2": "salicylic acid", "interaction_type": 47, "interaction_text": "The metabolism of salicylic acid can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "finasteride", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "loratadine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "losartan", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with losartan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "testosterone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "thiotepa", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "dantrolene", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "suprofen", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "epinastine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "azelastine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "quazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "argatroban", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "clonidine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "teniposide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "pentamidine", "interaction_type": 47, "interaction_text": "The metabolism of pentamidine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Naftifine", "interaction_type": 47, "interaction_text": "The metabolism of Naftifine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "amiodarone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "glyburide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "glyburide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "enalapril", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "flunarizine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "metronidazole", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "propofol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "enalapril", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "mefloquine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "mestranol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "clonidine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "aspirin", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "aspirin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "risperidone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "hexetidine", "interaction_type": 47, "interaction_text": "The metabolism of hexetidine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "promazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "pergolide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "caffeine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "carmustine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Imatinib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Letermovir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "vincristine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "zolpidem", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "nilutamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "nifedipine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "zidovudine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "glipizide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "benztropine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "glipizide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "timolol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "clomipramine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "lidocaine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "piperazine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "mianserin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "mianserin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "mianserin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "dopamine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "dopamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "dantrolene", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "ketamine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "propofol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with propofol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "propofol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with propofol.", "severity": 2}
{"drug1": "bupropion", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Perampanel", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "histamine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with histamine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "mianserin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "estramustine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "piperazine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "argatroban", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "isradipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "halothane", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "loperamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "loratadine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "propofol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "loratadine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Miltefosine", "interaction_type": 47, "interaction_text": "The metabolism of Miltefosine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "zolpidem", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "vincristine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "timolol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "clozapine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "pravastatin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "morphine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Artemether", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Udenafil", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "citalopram", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Quinine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "montelukast", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "theobromine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "temazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "quazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "proguanil", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "argatroban", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "argatroban", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "cephalexin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "mequitazine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "methadone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with methadone.", "severity": 2}
{"drug1": "flutamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "teniposide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "granisetron", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "bupropion", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "felbamate", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "selegiline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "doxazosin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "methadone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with methadone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "trazodone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "amsacrine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "promazine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with promazine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Artemether", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "bupropion", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "bupropion", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "granisetron", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "methadone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with methadone.", "severity": 2}
{"drug1": "clindamycin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "trazodone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "loratadine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "buspirone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "dapsone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "formoterol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "pergolide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "perphenazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Artemether", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "busulfan", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "ajmaline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ambroxol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "ambroxol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "rasagiline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "propofol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "tiagabine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "malathion", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with malathion.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "dapsone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "benztropine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "donepezil", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Netupitant", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "glyburide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Netupitant", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "irinotecan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "irinotecan", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "astemizole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Pefloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Pefloxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "mianserin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Neratinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Perampanel", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "docetaxel", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Encainide", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "propranolol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "disopyramide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "aspirin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "timolol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "histamine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with histamine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "diclofenac", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "bepridil", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "cisapride", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "prednisone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "alosetron", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "prednisone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "prednisone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "CICLOPIROX", "interaction_type": 47, "interaction_text": "The metabolism of CICLOPIROX can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "ketamine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "caffeine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Tavaborole", "interaction_type": 47, "interaction_text": "The metabolism of Tavaborole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "sertraline", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "caffeine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "theophylline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "ketamine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "clozapine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "praziquantel", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "lomustine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "glimepiride", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "alosetron", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "benztropine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "azelastine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "lidocaine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "indapamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "benzoic acid", "interaction_type": 47, "interaction_text": "The metabolism of benzoic acid can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "flutamide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "flutamide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "glipizide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "sertraline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "amoxapine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "propranolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "ipratropium", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "clonazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "proguanil", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Safinamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Safinamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "terbinafine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "indomethacin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "zolpidem", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "digitoxin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "diazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "diazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "nateglinide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "dyphylline", "drug2": "cinoxacin", "interaction_type": 47, "interaction_text": "The metabolism of cinoxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "diltiazem", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "morphine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "etodolac", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "etodolac", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Artemether", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "isradipine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Udenafil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Artemether", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "niclosamide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "norgestrel", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Encainide", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "meperidine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "nateglinide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "benazepril", "interaction_type": 47, "interaction_text": "The metabolism of benazepril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "amoxapine", "interaction_type": 47, "interaction_text": "The metabolism of amoxapine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "amsacrine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "metronidazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Perospirone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Permethrin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "nicotine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Perospirone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "disulfiram", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "omeprazole", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "donepezil", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "epinastine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "famotidine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "piperazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with Bevantolol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "buspirone", "drug2": "griseofulvin", "interaction_type": 47, "interaction_text": "The metabolism of griseofulvin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with STIRIPENTOL.", "severity": 2}
{"drug1": "estrone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with estrone.", "severity": 2}
{"drug1": "menadione", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with menadione.", "severity": 2}
{"drug1": "warfarin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "aspirin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "promazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "promazine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "progesterone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "riluzole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "NATAMYCIN", "interaction_type": 47, "interaction_text": "The metabolism of NATAMYCIN can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "estrone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "flecainide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Conivaptan", "interaction_type": 47, "interaction_text": "The metabolism of Conivaptan can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "lidocaine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Macitentan", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "domperidone", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "dapsone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "morphine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with morphine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "quinidine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "protriptyline", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "theophylline", "drug2": "ROSOXACIN", "interaction_type": 47, "interaction_text": "The metabolism of ROSOXACIN can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "testosterone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "carvedilol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ethanol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "naloxone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "naloxone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "sertraline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "propofol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with propofol.", "severity": 2}
{"drug1": "gliclazide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "astemizole", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "caffeine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "citalopram", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "donepezil", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "quazepam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "warfarin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "methyprylon", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "galanthamine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "benztropine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "caffeine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "sertraline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Imatinib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "clorazepate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "tretinoin", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "tretinoin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "temazepam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "sertraline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "morphine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "midazolam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "valsartan", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "ketamine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "ketamine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "pergolide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "selegiline", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "flutamide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "clozapine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "clozapine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "albendazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "maprotiline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "histamine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with histamine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "glimepiride", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "felbamate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "montelukast", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "clozapine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "pergolide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pergolide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "quinacrine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "quinacrine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "risperidone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "cisapride", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Udenafil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "Quinine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "mianserin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "ranitidine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "proguanil", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "letrozole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "sildenafil", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "bromazepam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Tramadol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "diazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "quazepam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "meperidine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "metronidazole", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "morphine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "estrone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "meperidine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "suprofen", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Torasemide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "morphine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "imipramine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "flutamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "pravastatin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "epinastine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Ecabet", "interaction_type": 47, "interaction_text": "The metabolism of Ecabet can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "enalapril", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "cephalexin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "enalapril", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "tazarotene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "loratadine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "teniposide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "teniposide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "estazolam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "menadione", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with menadione.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "CICLOPIROX", "interaction_type": 47, "interaction_text": "The metabolism of CICLOPIROX can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Capsaicin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Capsaicin.", "severity": 2}
{"drug1": "promazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Letermovir", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "loratadine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "promazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "promazine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "desipramine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "donepezil", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "dopamine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "aminophylline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "estrone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with estrone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Rifaximin.", "severity": 2}
{"drug1": "buspirone", "drug2": "THYMOL", "interaction_type": 47, "interaction_text": "The metabolism of THYMOL can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "loratadine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "omeprazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "mianserin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "isoniazid", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with isoniazid.", "severity": 2}
{"drug1": "ethanol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "codeine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "nicotine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "mestranol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Permethrin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "modafinil", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "triazolam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "modafinil", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "cocaine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "sertraline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "alosetron", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "clozapine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "tolterodine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "busulfan", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "piperazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "astemizole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "maprotiline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Permethrin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "sildenafil", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Perampanel", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "risperidone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "progesterone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "bupropion", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "sotalol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with sotalol.", "severity": 2}
{"drug1": "buspirone", "drug2": "EFINACONAZOLE", "interaction_type": 47, "interaction_text": "The metabolism of EFINACONAZOLE can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "moclobemide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "triamterene", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "sertraline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "antipyrine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "loperamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "meperidine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "toremifene", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "diltiazem", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "alosetron", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "formoterol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "propranolol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "meperidine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "norethindrone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "nicotine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "bupropion", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with atorvastatin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "doxazosin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "temazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "risperidone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "amsacrine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "proguanil", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "glimepiride", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "methadone", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with methadone.", "severity": 2}
{"drug1": "albendazole", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "albendazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "metronidazole", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "formoterol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "quinidine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "nicotine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "propranolol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "losartan", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with losartan.", "severity": 2}
{"drug1": "antipyrine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "morphine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cilnidipine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "diazepam", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "disulfiram", "interaction_type": 47, "interaction_text": "The metabolism of disulfiram can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "finasteride", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "cisapride", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Quinine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "timolol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with timolol.", "severity": 2}
{"drug1": "formoterol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "timolol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "nalidixic acid", "interaction_type": 47, "interaction_text": "The metabolism of nalidixic acid can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "trazodone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Netupitant", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "omeprazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "nabumetone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "mianserin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "testosterone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "felodipine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "testosterone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Encainide", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Encainide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "flecainide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "dapsone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "epinastine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "warfarin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "hesperetin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "triamterene", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "irinotecan", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "etoposide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "glyburide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "irinotecan", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "quinacrine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "busulfan", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "teniposide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "menadione", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with menadione.", "severity": 2}
{"drug1": "carmustine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "prednisone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "prednisone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "caffeine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "alosetron", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "teniposide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "valsartan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Rivaroxaban", "interaction_type": 47, "interaction_text": "The metabolism of Rivaroxaban can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "doxepin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "valsartan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Conivaptan.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "aspirin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "aspirin", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "chloroxine", "interaction_type": 47, "interaction_text": "The metabolism of chloroxine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "glipizide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "glipizide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "felbamate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "losartan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "felbamate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "felbamate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "malathion", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with malathion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "norethindrone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "histamine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "estrone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "testosterone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "nicardipine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "folic acid", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with folic acid.", "severity": 2}
{"drug1": "pravastatin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "ketamine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "ketamine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "estradiol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "midazolam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "praziquantel", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "cisapride", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "protriptyline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "histamine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "risperidone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Levomilnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Levomilnacipran can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "proguanil", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "carvedilol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Axitinib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "azelastine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "progesterone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "loratadine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "loperamide", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "loperamide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "letrozole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "mestranol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "vincristine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "caffeine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with amobarbital.", "severity": 2}
{"drug1": "paroxetine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "glyburide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "piperazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Macitentan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "lomustine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "lomustine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "lomustine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "clozapine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "clozapine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "montelukast", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Quinine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "ajmaline", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "epinastine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "nicotine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "etoposide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "clindamycin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "selegiline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "omeprazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "theophylline", "drug2": "Trovafloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Trovafloxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "selegiline", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "alclometasone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "selegiline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "midazolam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "histamine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "estramustine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "estramustine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "estramustine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "famotidine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "amsacrine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "granisetron", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "bupropion", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "buspirone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "teniposide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "warfarin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "promazine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with promazine.", "severity": 2}
{"drug1": "ethanol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "ethanol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "busulfan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "imipramine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "valsartan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "thalidomide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "tolnaftate", "interaction_type": 47, "interaction_text": "The metabolism of tolnaftate can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "modafinil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "modafinil", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "vinblastine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "dapsone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "etizolam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "tioconazole", "interaction_type": 47, "interaction_text": "The metabolism of tioconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "estrone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with estrone.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "paramethasone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "tetracycline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "paramethasone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "losartan", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "theophylline", "drug2": "fleroxacin", "interaction_type": 47, "interaction_text": "The metabolism of fleroxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "promethazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "propofol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with propofol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "triamterene", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "thalidomide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "buspirone", "drug2": "oxiconazole", "interaction_type": 47, "interaction_text": "The metabolism of oxiconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "carmustine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "estradiol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "risperidone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "progesterone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "sertraline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "enalapril", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "loperamide", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "estradiol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "loperamide", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "propofol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "caffeine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "propofol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "caffeine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "bepridil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "donepezil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "glucosamine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "propofol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "astemizole", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Axitinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "astemizole", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "levodopa", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "pergolide", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "cytarabine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "codeine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with codeine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "quinidine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "labetalol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "malathion", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with malathion.", "severity": 2}
{"drug1": "clozapine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "clozapine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "midazolam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "proguanil", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "codeine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with codeine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "indapamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "indapamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "indapamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "nystatin", "interaction_type": 47, "interaction_text": "The metabolism of nystatin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "nicotine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Safinamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "epinastine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "dantrolene", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "progesterone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "loratadine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "citalopram", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "nifedipine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "astemizole", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "estrone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with estrone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "proguanil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "zolpidem", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "dopamine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Apremilast", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "halothane", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "tolterodine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "loperamide", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "meperidine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "propofol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "niclosamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "citalopram", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "norgestrel", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "spiramycin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "ritonavir", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "miconazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "efavirenz", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "miconazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Perospirone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "naloxone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "loratadine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "nicotine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "mebendazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "VORTIOXETINE", "interaction_type": 47, "interaction_text": "The metabolism of VORTIOXETINE can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "toremifene", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "morphine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with morphine.", "severity": 2}
{"drug1": "morphine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "terbinafine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Pinaverium.", "severity": 2}
{"drug1": "montelukast", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Ethamolin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ethamolin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Pefloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Pefloxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "disulfiram", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "bupropion", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "irinotecan", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "methadone", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with methadone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "flunarizine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "sulconazole", "interaction_type": 47, "interaction_text": "The metabolism of sulconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "promazine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with promazine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "bupropion", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "meperidine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "histamine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "testosterone propionate", "interaction_type": 47, "interaction_text": "The metabolism of testosterone propionate can be decreased when combined with diethylstilbestrol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with oxprenolol.", "severity": 2}
{"drug1": "quazepam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "buspirone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Anidulafungin", "interaction_type": 47, "interaction_text": "The metabolism of Anidulafungin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "teniposide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "suprofen", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "losartan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "suprofen", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "resveratrol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "busulfan", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Melatonin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with mifepristone.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "niclosamide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "prazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "tolperisone", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "theophylline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "theophylline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "propranolol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "lidocaine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "promethazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "etizolam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "praziquantel", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "losartan", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "progesterone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "testosterone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "promethazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "dopamine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "busulfan", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "propofol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Dothiepin.", "severity": 2}
{"drug1": "propofol", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with propofol.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "sibutramine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "methadone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Pregabalin.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Efonidipine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "mestranol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "warfarin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "prednisone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "codeine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with codeine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "estradiol", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "doxepin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "alosetron", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Macitentan", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "indapamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "valsartan", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "nateglinide", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "valsartan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "ipratropium", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "doxepin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "teniposide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "mianserin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Artemether", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "toremifene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "zidovudine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "zolpidem", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "doxepin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Rifaximin.", "severity": 2}
{"drug1": "nicotine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "histamine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "malathion", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with malathion.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "dantrolene", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "selegiline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with atorvastatin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "famciclovir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "propofol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with propofol.", "severity": 2}
{"drug1": "diazepam", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "proguanil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "alclometasone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "indapamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "captopril", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "isradipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "nifedipine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "domperidone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "raloxifene", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "methadone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "indomethacin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "clofibrate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "diazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "clofibrate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "diazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "dyphylline", "drug2": "thiabendazole", "interaction_type": 47, "interaction_text": "The metabolism of thiabendazole can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "formoterol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "lomustine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "formoterol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "halothane", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "calcitriol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "THYMOL", "interaction_type": 47, "interaction_text": "The metabolism of THYMOL can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "zopiclone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "loratadine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "cephalexin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "famotidine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "teniposide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "busulfan", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "gliclazide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "estradiol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "donepezil", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "felodipine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "caffeine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Tolcapone", "interaction_type": 47, "interaction_text": "The metabolism of Tolcapone can be decreased when combined with methyldopa.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "vinblastine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "labetalol", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Macitentan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "busulfan", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "clofazimine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "amsacrine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ajmaline", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ajmaline", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "miconazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "estrone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "teniposide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "teniposide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "digoxin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "ketamine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "labetalol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "famciclovir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "labetalol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "rasagiline", "interaction_type": 47, "interaction_text": "The metabolism of rasagiline can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "halothane", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "etodolac", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "glyburide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "naloxone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cocaine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "cocaine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "propofol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "mianserin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "progesterone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "estradiol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "progesterone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "cocaine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "cocaine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "bepridil", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "cocaine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Perampanel", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "calcitriol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "calcitriol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "loperamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "bupropion", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "halothane", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with halothane.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "mestranol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "mestranol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "methyprylon", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "etodolac", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "amoxapine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "desipramine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "selegiline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "trandolapril", "interaction_type": 47, "interaction_text": "The metabolism of trandolapril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Levomilnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Levomilnacipran can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "apomorphine", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "nateglinide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "propranolol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "losartan", "drug2": "hexetidine", "interaction_type": 47, "interaction_text": "The metabolism of hexetidine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "lomustine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "mianserin", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "theobromine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "theobromine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "histamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "histamine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with histamine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "toremifene", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "bupropion", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "etodolac", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "bupropion", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "ritonavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "indapamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "lomustine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "ketamine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "doxepin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with tolfenamic acid.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "cisapride", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "ritonavir", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ritonavir", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "albendazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "pergolide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "isradipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "etizolam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "amprenavir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "methadone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with methadone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "captopril", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with captopril.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "propranolol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "4-aminopyridine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with 4-aminopyridine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "hexetidine", "interaction_type": 47, "interaction_text": "The metabolism of hexetidine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "cisapride", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "azelastine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "suprofen", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "paramethasone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "paramethasone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Quinine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with barnidipine.", "severity": 2}
{"drug1": "histamine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "metronidazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "metronidazole", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "ambroxol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "morphine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with morphine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "granisetron", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "granisetron", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Vildagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Vildagliptin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "promazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with promazine.", "severity": 2}
{"drug1": "atenolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with atenolol.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "dantrolene", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "estradiol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "testosterone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "clonidine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "formoterol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "prazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "montelukast", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "estazolam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "erythromycin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nystatin", "interaction_type": 47, "interaction_text": "The metabolism of nystatin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "zonisamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "progesterone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Levomilnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Levomilnacipran can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "progesterone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "tinidazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "azelastine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "imipramine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "prednisone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "promazine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with promazine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "dapsone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "malathion", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with malathion.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "levodopa", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "estrone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "donepezil", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "theophylline", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "vinblastine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "vinblastine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "procarbazine", "interaction_type": 47, "interaction_text": "The metabolism of procarbazine can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "ajmaline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "donepezil", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "halothane", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "buspirone", "drug2": "sulconazole", "interaction_type": 47, "interaction_text": "The metabolism of sulconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "lomustine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "astemizole", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "diltiazem", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "pentamidine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "flutamide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "indapamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "estradiol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "sparfloxacin", "interaction_type": 47, "interaction_text": "The metabolism of sparfloxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "piperazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "proguanil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "ketamine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "risperidone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "mianserin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "proguanil", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "irinotecan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "letrozole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "etizolam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Encainide", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "etizolam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "testosterone", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "flurazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "nilutamide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "indapamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "propofol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with propofol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "tolterodine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Neratinib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "ranitidine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "efavirenz", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "loperamide", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "letrozole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "ritonavir", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "meperidine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "losartan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "fosinopril", "interaction_type": 47, "interaction_text": "The metabolism of fosinopril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "labetalol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "alosetron", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "trimipramine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with codeine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "warfarin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "quazepam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "theobromine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "epinastine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "selegiline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "midazolam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "amprenavir", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "irbesartan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "argatroban", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "theobromine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Artemether", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "formoterol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "felodipine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "disulfiram", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "loratadine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "perphenazine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "buspirone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "midazolam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "quinidine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "domperidone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "loratadine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "benztropine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "progesterone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "dopamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "benztropine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "benztropine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "paramethasone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "promethazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "losartan", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "levodopa", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "benztropine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "mestranol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Asenapine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "trazodone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "carmustine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "methadone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with methadone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "sertraline", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "finasteride", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "diclofenac", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "sibutramine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "carmustine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "estradiol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "azelastine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "albendazole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "halothane", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "vincristine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Macitentan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "caffeine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "trazodone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Udenafil", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "alprazolam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "miconazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "nilutamide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nilutamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "theophylline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "warfarin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "quinacrine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "etizolam", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "labetalol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "clozapine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "digoxin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "granisetron", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "sotalol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with sotalol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "sertraline", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "pergolide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "proguanil", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "captopril", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "risperidone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "piperazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "progesterone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "dantrolene", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "progesterone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "modafinil", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "argatroban", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "mianserin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "temazepam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "azithromycin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "zolpidem", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "clofibrate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "zolpidem", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "dopamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "clonazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "methyprylon", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "antipyrine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "captopril", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "tolterodine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "loperamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "modafinil", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "bupropion", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Artemether", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "thiotepa", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "timolol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with timolol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "flunisolide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Asenapine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "mequitazine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "flutamide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "mequitazine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "montelukast", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "piperazine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "oxazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "lomustine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "quazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "epinastine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "methadone", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with methadone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "teniposide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "promazine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with promazine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "promazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with acebutolol.", "severity": 2}
{"drug1": "bupropion", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "tolperisone", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "bupropion", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "diazepam", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "buspirone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "alprenolol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "zidovudine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "teniposide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "teniposide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "etoposide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "etoposide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "metoprolol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "busulfan", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "dapsone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "moclobemide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "nifedipine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "estrone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with estrone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "flurazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "ambroxol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "ambroxol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "domperidone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "etizolam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Apixaban", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "teniposide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "dopamine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "flecainide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "loperamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "losartan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with losartan.", "severity": 2}
{"drug1": "propofol", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "astemizole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "protriptyline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "leflunomide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "rapamycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "letrozole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "irbesartan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "halothane", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "progesterone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "progesterone", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "warfarin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "estradiol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "caffeine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "salicylic acid", "interaction_type": 47, "interaction_text": "The metabolism of salicylic acid can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "caffeine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "estradiol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "loperamide", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "estradiol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "timolol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with timolol.", "severity": 2}
{"drug1": "alosetron", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "estrone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "indinavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "cisapride", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "risperidone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "clorazepate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "selegiline", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "propranolol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "azelastine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "nicotine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "flutamide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "methadone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "cisapride", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "cisapride", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Apixaban", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "propofol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with propofol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "calcitriol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "calcitriol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "indapamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "pentamidine", "interaction_type": 47, "interaction_text": "The metabolism of pentamidine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "letrozole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "buspirone", "drug2": "Naftifine", "interaction_type": 47, "interaction_text": "The metabolism of Naftifine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "cephalexin", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "propranolol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Artemether", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "progesterone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "etodolac", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "terbinafine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "morphine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "astemizole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "finasteride", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "niclosamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "diazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "metronidazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "metronidazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "formoterol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "eperisone", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with eperisone.", "severity": 2}
{"drug1": "meperidine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "suprofen", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "suprofen", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "enflurane", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with enflurane.", "severity": 2}
{"drug1": "caffeine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Torasemide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "finasteride", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "finasteride", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "losartan", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with losartan.", "severity": 2}
{"drug1": "amsacrine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "etoposide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "piperazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "argatroban", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "amsacrine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "estramustine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "loperamide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "gliclazide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "trimipramine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "estramustine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "docetaxel", "drug2": "cerulenin", "interaction_type": 47, "interaction_text": "The metabolism of cerulenin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "cephalexin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "labetalol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "estrone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "methadone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "promazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "halothane", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "promethazine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "estrone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "donepezil", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "suprofen", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "aminophylline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "imipramine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "busulfan", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "busulfan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "busulfan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "BALSALAZIDE", "interaction_type": 47, "interaction_text": "The metabolism of BALSALAZIDE can be decreased when combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "losartan", "drug2": "nystatin", "interaction_type": 47, "interaction_text": "The metabolism of nystatin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "docetaxel", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Imatinib", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "flecainide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with BUPRANOLOL.", "severity": 2}
{"drug1": "cytarabine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "testosterone", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "testosterone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "promethazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "ethanol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "etizolam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "estradiol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "estradiol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "triazolam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Perampanel", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "benztropine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "ethanol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "domperidone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "risperidone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "citalopram", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "mestranol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "epinastine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "irinotecan", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "meperidine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "azelastine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "estradiol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "quinidine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Escitalopram", "interaction_type": 47, "interaction_text": "The metabolism of Escitalopram can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "ketamine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "alosetron", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "doxepin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Macitentan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "sildenafil", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "sildenafil", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "proguanil", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "formoterol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Milnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Milnacipran can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "tetracycline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Perospirone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "felbamate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "quinidine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "felbamate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "montelukast", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "captopril", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with captopril.", "severity": 2}
{"drug1": "meperidine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "thalidomide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "quinacrine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "propranolol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "lomustine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "lomustine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "nicotine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "levodopa", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "omeprazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "letrozole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "letrozole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "niclosamide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "buspirone", "drug2": "5-Fluorocytosine", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorocytosine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "butenafine", "interaction_type": 47, "interaction_text": "The metabolism of butenafine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "Olsalazine", "interaction_type": 47, "interaction_text": "The metabolism of Olsalazine can be decreased when combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "methyprylon", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "prazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "nicotine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "felbamate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Quinine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "meperidine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "cocaine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "diazepam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "etoposide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "dolasetron", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "diazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Quinine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "captopril", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Encainide", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "estrone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "propranolol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "naloxone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "NATAMYCIN", "interaction_type": 47, "interaction_text": "The metabolism of NATAMYCIN can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "captopril", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with captopril.", "severity": 2}
{"drug1": "quazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "ethanol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "quazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "etoposide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "pimozide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "quazepam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "domperidone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "teniposide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "teniposide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "azelastine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "azelastine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "domperidone", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "aspirin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "AMPHETAMINE", "interaction_type": 47, "interaction_text": "The metabolism of AMPHETAMINE can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Perospirone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "hesperetin", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "donepezil", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "flunarizine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "imipramine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Riociguat", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "vinblastine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "meperidine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "nicotine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "malathion", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with malathion.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "donepezil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "haloperidol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "temazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "labetalol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "cilostazol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "dopamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "dopamine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "testosterone propionate", "interaction_type": 47, "interaction_text": "The metabolism of testosterone propionate can be decreased when combined with Micafungin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "felbamate", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "triazolam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "ajmaline", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "calcitriol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "progesterone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "mianserin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "ethanol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "halothane", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "histamine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dopamine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "histamine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "protriptyline", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with tolfenamic acid.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "etizolam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "astemizole", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "ropinirole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "citalopram", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "alosetron", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "dopamine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "miconazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "astemizole", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "letrozole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "amprenavir", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "midazolam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "astemizole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "desipramine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "clomipramine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "halothane", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "halothane", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "halothane", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "zolpidem", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "alosetron", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "alosetron", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "griseofulvin", "interaction_type": 47, "interaction_text": "The metabolism of griseofulvin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "loperamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "mestranol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "nateglinide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "terbinafine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "estrone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "clorazepate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "dapsone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "temazepam", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "clozapine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "codeine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with codeine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "modafinil", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "epinastine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "epinastine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "epinastine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "nicotine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "bupropion", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "temazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "bupropion", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "azelastine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "glimepiride", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "histamine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with histamine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "doxazosin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "famotidine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "vinblastine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "formoterol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "etoposide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "histamine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "captopril", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "mequitazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "propranolol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "buspirone", "drug2": "miconazole", "interaction_type": 47, "interaction_text": "The metabolism of miconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "morphine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "loratadine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "ajmaline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "loratadine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Escitalopram", "interaction_type": 47, "interaction_text": "The metabolism of Escitalopram can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "trazodone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "etoposide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "triamterene", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "testosterone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "levodopa", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Encainide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "flecainide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "glyburide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "etoposide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "imipramine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "donepezil", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "mianserin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "carmustine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "leflunomide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "teniposide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "menadione", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with menadione.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "donepezil", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "cytarabine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "donepezil", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "caffeine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "letrozole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Letermovir", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Asunaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Asunaprevir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "theophylline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "flecainide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "mianserin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "doxepin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "cilostazol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "azelastine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "labetalol", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "warfarin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "betaxolol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "ajmaline", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "alclometasone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "trimipramine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "malathion", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with malathion.", "severity": 2}
{"drug1": "triazolam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "testosterone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "dapsone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "folic acid", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with folic acid.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "proguanil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "proguanil", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "estradiol", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estazolam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "estradiol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "quinidine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "albendazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "midazolam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "PERINDOPRIL", "interaction_type": 47, "interaction_text": "The metabolism of PERINDOPRIL can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "halothane", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Safinamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "buspirone", "drug2": "hexetidine", "interaction_type": 47, "interaction_text": "The metabolism of hexetidine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "progesterone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "promazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "astemizole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "timolol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "nicotine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "toremifene", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "timolol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with timolol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "clonazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "progesterone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "etodolac", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "nilutamide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "alosetron", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "vincristine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "alprazolam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "isradipine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ketamine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "caffeine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Artemether", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "desipramine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Artemether", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "loratadine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loperamide", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "timolol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "quinidine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with Nebivolol.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "diclofenac", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Perampanel", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "methyprylon", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "losartan", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Gatifloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Gatifloxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "clozapine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "labetalol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "selegiline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "etoposide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "selegiline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "indomethacin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with acebutolol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "buspirone", "drug2": "rapamycin", "interaction_type": 47, "interaction_text": "The metabolism of rapamycin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "histamine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with histamine.", "severity": 2}
{"drug1": "indinavir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "lomustine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "lomustine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "lomustine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "trazodone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "naloxone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "menadione", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with menadione.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "quinidine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "irinotecan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "mequitazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "miconazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Apixaban", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Letermovir", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "estramustine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Riociguat", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "quazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "timolol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with timolol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "thalidomide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "aspirin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "teniposide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "codeine", "drug2": "Pasireotide", "interaction_type": 47, "interaction_text": "The metabolism of Pasireotide can be decreased when combined with codeine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "busulfan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "busulfan", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "flecainide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with sumatriptan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "riluzole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "cerulenin", "interaction_type": 47, "interaction_text": "The metabolism of cerulenin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "buspirone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "riluzole", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "naloxone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "estrone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "naloxone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "cytarabine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "naloxone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "ambroxol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "lomustine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "ajmaline", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "dapsone", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "naloxone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "estrone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "azelastine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "epinastine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "labetalol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "estradiol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "astemizole", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "domperidone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "azelastine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "progesterone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "caffeine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "MOEXIPRIL", "interaction_type": 47, "interaction_text": "The metabolism of MOEXIPRIL can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "trazodone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "warfarin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "sertraline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Rivaroxaban", "interaction_type": 47, "interaction_text": "The metabolism of Rivaroxaban can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "estradiol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "loperamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "loperamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "domperidone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "rapamycin", "interaction_type": 47, "interaction_text": "The metabolism of rapamycin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "diltiazem", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ramipril", "interaction_type": 47, "interaction_text": "The metabolism of ramipril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "niclosamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "haloperidol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "loperamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "alosetron", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "caffeine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "alosetron", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Artemether", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Artemether", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "theophylline", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "ritonavir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with propafenone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "calcitriol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "temazepam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "proguanil", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "toremifene", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "clozapine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "clozapine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Azelnidipine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "indapamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "clomipramine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "estradiol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "quinacrine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "quinacrine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "doxepin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "citalopram", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "propofol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "nicergoline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "mianserin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "felbamate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "felbamate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "valsartan", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "felbamate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "granisetron", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "clonidine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "dopamine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "ranitidine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "ranitidine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Artemether", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "cisapride", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "quinidine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "gliclazide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "bromazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "ranitidine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "quetiapine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "nifedipine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "dopamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Trovafloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Trovafloxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "dapsone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "halothane", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "dapsone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "cisapride", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "methyprylon", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "methyprylon", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "spiramycin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "argatroban", "interaction_type": 47, "interaction_text": "The metabolism of argatroban can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "bifonazole", "interaction_type": 47, "interaction_text": "The metabolism of bifonazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "montelukast", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "loratadine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "temazepam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "mebendazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "mebendazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "alprenolol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "toremifene", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Ethamolin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ethamolin.", "severity": 2}
{"drug1": "pimozide", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "thiothixene", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "atenolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with atenolol.", "severity": 2}
{"drug1": "loratadine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "nadolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with nadolol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "progesterone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "lomustine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "zonisamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "levodopa", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "clofazimine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "clonidine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "methadone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with methadone.", "severity": 2}
{"drug1": "prazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "montelukast", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "donepezil", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "theophylline", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "theophylline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "dapsone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "resveratrol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "promazine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Melatonin", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "prazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "prazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "tolperisone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "tolperisone", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "tetracycline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "tolperisone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "testosterone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Encainide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Encainide", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Encainide", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "labetalol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "flunisolide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "proguanil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "donepezil", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "propofol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "clomipramine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "azelastine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "valsartan", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "bepridil", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "loperamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "leflunomide", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "labetalol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "sertraline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sertraline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "miconazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "thiamylal", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "vincristine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "sibutramine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Neratinib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "Quinine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "warfarin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Torasemide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "valsartan", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "tretinoin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "losartan", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "progesterone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "caffeine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mitoxantrone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Letermovir", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "digoxin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "ketamine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "doxepin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "manidipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with manidipine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Riociguat", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "nicotine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "lomustine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "clonidine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "albendazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "ketamine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "pergolide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "primidone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with primidone.", "severity": 2}
{"drug1": "labetalol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "terbinafine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "doxepin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "zidovudine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "codeine", "drug2": "Octreotide", "interaction_type": 47, "interaction_text": "The metabolism of Octreotide can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "piperazine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "piperazine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "histamine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "antipyrine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "Apixaban", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "captopril", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with captopril.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "finasteride", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "buspirone", "drug2": "NATAMYCIN", "interaction_type": 47, "interaction_text": "The metabolism of NATAMYCIN can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "nicergoline", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "trimipramine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "epinastine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "methadone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with methadone.", "severity": 2}
{"drug1": "cisapride", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "clofibrate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "diazepam", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Quinine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Quinine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "finasteride", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "felbamate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "levodopa", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "digitoxin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "clonazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "Encainide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "valsartan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "aspirin", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "eperisone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with eperisone.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "spiramycin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "clozapine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "griseofulvin", "interaction_type": 47, "interaction_text": "The metabolism of griseofulvin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "cocaine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "montelukast", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "alosetron", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "methadone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with methadone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "busulfan", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "anagrelide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "trazodone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "caffeine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "prednisone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "promazine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with promazine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Sertaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Sertaconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "cephalexin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "trimetrexate", "interaction_type": 47, "interaction_text": "The metabolism of trimetrexate can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "rapamycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "amsacrine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "nystatin", "interaction_type": 47, "interaction_text": "The metabolism of nystatin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "amsacrine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "gliclazide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "testosterone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "flunarizine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "nicotine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "montelukast", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "theophylline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "cocaine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "estrone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with estrone.", "severity": 2}
{"drug1": "glimepiride", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "progesterone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "amoxapine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "mianserin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "aspirin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "aspirin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "propofol", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with propofol.", "severity": 2}
{"drug1": "losartan", "drug2": "Naftifine", "interaction_type": 47, "interaction_text": "The metabolism of Naftifine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "losartan", "drug2": "pentamidine", "interaction_type": 47, "interaction_text": "The metabolism of pentamidine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "valsartan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "felbamate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "zidovudine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "duloxetine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "calcitriol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "calcitriol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "glipizide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "azithromycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "benztropine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "benztropine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "azelastine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "benztropine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "benztropine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "estradiol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "cocaine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "finasteride", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "bepridil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "progesterone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "antipyrine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "caffeine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "loratadine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Anidulafungin", "interaction_type": 47, "interaction_text": "The metabolism of Anidulafungin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Artemether", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "nateglinide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "letrozole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "letrozole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "lomustine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "dopamine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "sertraline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "buspirone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "sertraline", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sertraline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "sertraline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "dicumarol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "epinastine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "flutamide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "tretinoin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Efonidipine.", "severity": 2}
{"drug1": "theobromine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "theobromine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "theobromine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "histamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "histamine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "histamine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "glimepiride", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "piperazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "Riociguat", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "pergolide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "famotidine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "clozapine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "loperamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "thiotepa", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "glimepiride", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "bupropion", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "midazolam", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Apixaban", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "histamine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with histamine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "formoterol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "argatroban", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "diazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "alprazolam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "alprazolam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "felodipine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "disopyramide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "riluzole", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "cisapride", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "glipizide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "cilazapril", "interaction_type": 47, "interaction_text": "The metabolism of cilazapril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Spirapril", "interaction_type": 47, "interaction_text": "The metabolism of Spirapril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "ajmaline", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "morphine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with morphine.", "severity": 2}
{"drug1": "imipramine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "morphine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "morphine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Netupitant", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "enalapril", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "estazolam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "quazepam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "testosterone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "clonidine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "promazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "imipramine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "ipratropium", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "glucosamine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "gliclazide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "domperidone", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Isoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Isoconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "risperidone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "clonidine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "protriptyline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "clindamycin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "aminophylline", "drug2": "cinoxacin", "interaction_type": 47, "interaction_text": "The metabolism of cinoxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "vinblastine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "promazine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with promazine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "donepezil", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "clonidine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "vincristine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "norethindrone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "glipizide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "azelastine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "nateglinide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "zidovudine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "argatroban", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "azelastine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "alosetron", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Butoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Butoconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "triazolam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "astemizole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "indapamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "dopamine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with penbutolol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "progesterone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "azelastine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "propofol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "amprenavir", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Permethrin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "mianserin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "halothane", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "dapsone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "epinastine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "epinastine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "ranitidine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "efavirenz", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "zolpidem", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "mianserin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "mestranol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "loratadine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "buspirone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "captopril", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with captopril.", "severity": 2}
{"drug1": "flutamide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "metronidazole", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "finasteride", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "tiagabine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "montelukast", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "tiagabine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "thiothixene", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Alogliptin", "interaction_type": 47, "interaction_text": "The metabolism of Alogliptin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "naloxone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Darunavir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "famciclovir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "famciclovir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "epinastine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "zonisamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "miconazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "flunarizine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "bupropion", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "montelukast", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "simvastatin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with sumatriptan.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "bupropion", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "dapsone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "bupropion", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "bupropion", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "loratadine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "tolperisone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Apixaban", "interaction_type": 47, "interaction_text": "The metabolism of Apixaban can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "alprazolam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "tolperisone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "moclobemide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "terconazole", "interaction_type": 47, "interaction_text": "The metabolism of terconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "dapsone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "losartan", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "cytarabine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "ambroxol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "midazolam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "ethanol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "niclosamide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "ambroxol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "domperidone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "levodopa", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "procarbazine", "interaction_type": 47, "interaction_text": "The metabolism of procarbazine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Dienogest", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "promethazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "quinapril", "interaction_type": 47, "interaction_text": "The metabolism of quinapril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "benztropine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "trazodone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Netupitant", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "irinotecan", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Dothiepin.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "enalapril", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "felodipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "astemizole", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "flunarizine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Phenelzine", "interaction_type": 47, "interaction_text": "The metabolism of Phenelzine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "leflunomide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "trazodone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "azelastine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Conivaptan.", "severity": 2}
{"drug1": "norgestrel", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "norgestrel", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "oxycodone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "flunarizine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "sertraline", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "flunarizine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "caffeine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "carmustine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "carmustine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "carmustine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "modafinil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "losartan", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "sibutramine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "doxepin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "lisinopril", "interaction_type": 47, "interaction_text": "The metabolism of lisinopril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "alosetron", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Macitentan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "azelastine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "primidone", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with primidone.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "doxepin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "aspirin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "valsartan", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "clozapine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "warfarin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "sotalol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with sotalol.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "argatroban", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "zopiclone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "codeine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "zidovudine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "selegiline", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Axitinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "mianserin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "propofol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "propranolol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "methyprylon", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Tramadol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "dapsone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "niclosamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "loratadine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "perphenazine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "dapsone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Escitalopram", "interaction_type": 47, "interaction_text": "The metabolism of Escitalopram can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "formoterol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "halothane", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "dapsone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "tolterodine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "metronidazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "maprotiline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "ritonavir", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "desipramine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Artemether", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Quinine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "olanzapine", "interaction_type": 47, "interaction_text": "The metabolism of olanzapine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "loratadine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "dolasetron", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "naloxone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "naloxone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "naloxone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "toremifene", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "toremifene", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "morphine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "Netupitant", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "sertraline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "morphine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "methadone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with methadone.", "severity": 2}
{"drug1": "argatroban", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "quazepam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "terbinafine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "halothane", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with halothane.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "estradiol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "benztropine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "quazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "mestranol", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "rapamycin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "granisetron", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "zonisamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "selegiline", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Melatonin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "promazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "haloperidol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "diazepam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Apixaban", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "buspirone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "vincristine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "buspirone", "drug2": "Butoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Butoconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "etoposide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Tolcapone", "interaction_type": 47, "interaction_text": "The metabolism of Tolcapone can be decreased when combined with Micafungin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "losartan", "drug2": "griseofulvin", "interaction_type": 47, "interaction_text": "The metabolism of griseofulvin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "riluzole", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "praziquantel", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "estrone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with estrone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Encainide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "ajmaline", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ajmaline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "morphine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Netupitant", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "domperidone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "finasteride", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "propofol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "dopamine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "protriptyline", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "vinblastine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "nilutamide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "tolterodine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "mianserin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "tolterodine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "prednisone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "epinastine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "propofol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "glyburide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Neratinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "astemizole", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "dopamine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "ranitidine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "prednisone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "albendazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "raloxifene", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "chloroquine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "loperamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "halothane", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "irbesartan", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "amoxapine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "theophylline", "drug2": "norfloxacin", "interaction_type": 47, "interaction_text": "The metabolism of norfloxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "caffeine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "sertraline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "sertraline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Artemether", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "mestranol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "sertraline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "timolol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "buspirone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "quinidine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "valsartan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "miconazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Letermovir", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "ketamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "ritonavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "lomustine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "ketamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ketamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "theobromine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "flutamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "theobromine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "histamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "histamine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with histamine.", "severity": 2}
{"drug1": "histamine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "bupropion", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "codeine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with codeine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "codeine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with codeine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "methadone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "bupropion", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "midazolam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "proguanil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "proguanil", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "etodolac", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "dapsone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "triazolam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "formoterol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "lisinopril", "interaction_type": 47, "interaction_text": "The metabolism of lisinopril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "sildenafil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "buspirone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "terbinafine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "methadone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "histamine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with histamine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "metronidazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "suprofen", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "suprofen", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "meperidine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "meperidine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "etoposide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "granisetron", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "epinastine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "granisetron", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "modafinil", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "nicotine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Netupitant", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "flutamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "promazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "montelukast", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with BOPINDOLOL.", "severity": 2}
{"drug1": "meprobamate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "erythromycin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "MOEXIPRIL", "interaction_type": 47, "interaction_text": "The metabolism of MOEXIPRIL can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with BUPRANOLOL.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "doxazosin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "gliclazide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "imipramine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "caffeine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "norfloxacin", "interaction_type": 47, "interaction_text": "The metabolism of norfloxacin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "disulfiram", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "disulfiram", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "estramustine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "glyburide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "omeprazole", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "caffeine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Saxagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Saxagliptin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "progesterone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "theophylline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "mefloquine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "azelastine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "digoxin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "flecainide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Gemifloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Gemifloxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with naratriptan.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "estrone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "promazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "promazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "promazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with promazine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "cephalexin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "meperidine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "estrone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with estrone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "aminophylline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "flecainide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "testosterone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "testosterone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Escitalopram", "interaction_type": 47, "interaction_text": "The metabolism of Escitalopram can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "donepezil", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Letermovir", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "felodipine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "ethanol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "losartan", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with losartan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "bepridil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "etizolam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "etizolam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "estradiol", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "nevirapine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Safinamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "halothane", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "quazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "temazepam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "warfarin", "drug2": "sulfinpyrazone", "interaction_type": 47, "interaction_text": "The metabolism of sulfinpyrazone can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "dopamine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "halothane", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "tolterodine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "caffeine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "propofol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with propofol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "caffeine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "amprenavir", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Amrinone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Amrinone.", "severity": 2}
{"drug1": "raloxifene", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "doxepin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "prazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "nilutamide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "malathion", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with malathion.", "severity": 2}
{"drug1": "clozapine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "sertraline", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "lomustine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "quinidine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "clofibrate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "dapsone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "zaleplon", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "zaleplon", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "ketamine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "nicergoline", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Risedronic acid.", "severity": 2}
{"drug1": "doxepin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "felbamate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "temazepam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "morphine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "pergolide", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "clozapine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "clozapine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "thiotepa", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "trimipramine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "methadone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with methadone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "methadone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with methadone.", "severity": 2}
{"drug1": "granisetron", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "bupropion", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Perospirone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "clozapine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "meperidine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "glimepiride", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "tetracycline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "loratadine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "thioguanine", "drug2": "mesalamine", "interaction_type": 47, "interaction_text": "The metabolism of mesalamine can be decreased when combined with thioguanine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "busulfan", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "estrone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "loratadine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "calcitriol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "metronidazole", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "cocaine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "captopril", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "alprenolol", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "trazodone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "morphine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "estrone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estramustine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with Metipranolol.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "estrone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with estrone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "riluzole", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "quazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "teniposide", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "clonidine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "thiotepa", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "clonidine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "gliclazide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "losartan", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Encainide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "trimipramine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "teniposide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "teniposide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "donepezil", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "teniposide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "bepridil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "mestranol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "mestranol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Caspofungin", "interaction_type": 47, "interaction_text": "The metabolism of Caspofungin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "tolnaftate", "interaction_type": 47, "interaction_text": "The metabolism of tolnaftate can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "mestranol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "methadone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with methadone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "promazine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "clindamycin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "menadione", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with menadione.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "caffeine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "pentamidine", "interaction_type": 47, "interaction_text": "The metabolism of pentamidine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Naftifine", "interaction_type": 47, "interaction_text": "The metabolism of Naftifine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "carmustine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "felodipine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "loratadine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "donepezil", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "methadone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with methadone.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "aminophylline", "drug2": "norfloxacin", "interaction_type": 47, "interaction_text": "The metabolism of norfloxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "loratadine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "buspirone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "pergolide", "drug2": "rasagiline", "interaction_type": 47, "interaction_text": "The metabolism of rasagiline can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "estrone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with estrone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "doxepin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "donepezil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "albendazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "testosterone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "triamterene", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "codeine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with codeine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "dopamine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "dopamine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "sertraline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "felbamate", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "citalopram", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "imipramine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "astemizole", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "amprenavir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "astemizole", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "amprenavir", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "histamine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with histamine.", "severity": 2}
{"drug1": "glyburide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "glyburide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "nicotine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "sertraline", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "codeine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with codeine.", "severity": 2}
{"drug1": "nilutamide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "bepridil", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "piperazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "tazarotene", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "halothane", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "progesterone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Safinamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "maprotiline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "maprotiline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "loperamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "dapsone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "loperamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "loperamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "letrozole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "zolpidem", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "morphine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "diltiazem", "drug2": "captopril", "interaction_type": 47, "interaction_text": "The metabolism of captopril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "metronidazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "meperidine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "argatroban", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "modafinil", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "loratadine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "cytarabine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "gliclazide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "levodopa", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "montelukast", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "temazepam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "temazepam", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "alprenolol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "clozapine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "codeine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with codeine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with oxprenolol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "granisetron", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "famciclovir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "mequitazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "pergolide", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "midazolam", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "enalapril", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "pergolide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "formoterol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "etodolac", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "histamine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with histamine.", "severity": 2}
{"drug1": "histamine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "estramustine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "selegiline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Encainide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "bupropion", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "clorazepate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "diazepam", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "promazine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with promazine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "estrone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with estrone.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dapsone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "tolperisone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with Arotinolol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "ambroxol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "ajmaline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ambroxol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Micafungin", "interaction_type": 47, "interaction_text": "The metabolism of Micafungin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "dopamine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "loperamide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "astemizole", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "flurazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "zidovudine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "irinotecan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "caffeine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "levodopa", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "omeprazole", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "dopamine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "dopamine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "flunarizine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "progesterone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "estazolam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "loperamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "oxycodone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "mianserin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "sertraline", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sertraline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "loperamide", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "loperamide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "timolol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with timolol.", "severity": 2}
{"drug1": "mianserin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Bivalirudin", "interaction_type": 47, "interaction_text": "The metabolism of Bivalirudin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "5-Fluorocytosine", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorocytosine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "bepridil", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "butenafine", "interaction_type": 47, "interaction_text": "The metabolism of butenafine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "alosetron", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Artemether", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "olanzapine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "halothane", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "famciclovir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "mesalamine", "interaction_type": 47, "interaction_text": "The metabolism of mesalamine can be decreased when combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "oxazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "losartan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with losartan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "azelastine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "norethindrone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "lidocaine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "ranitidine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "doxepin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "glipizide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "warfarin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "morphine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "promethazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "praziquantel", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "alclometasone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "desipramine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "midazolam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "desipramine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "clozapine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "bifonazole", "interaction_type": 47, "interaction_text": "The metabolism of bifonazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "cisapride", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "glipizide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "propranolol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "dantrolene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "pergolide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "pergolide", "drug2": "AMPHETAMINE", "interaction_type": 47, "interaction_text": "The metabolism of AMPHETAMINE can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Tramadol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "cisapride", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "modafinil", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "felbamate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "propofol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "ondansetron", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "nicotine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "piperazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "desipramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "albendazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "mestranol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "antipyrine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "formoterol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "halothane", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "granisetron", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "enflurane", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with enflurane.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "triazolam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Artemether", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "loperamide", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "celecoxib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "cephalexin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "testosterone propionate", "interaction_type": 47, "interaction_text": "The metabolism of testosterone propionate can be decreased when combined with methyldopa.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "propranolol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "nalidixic acid", "interaction_type": 47, "interaction_text": "The metabolism of nalidixic acid can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "losartan", "drug2": "Tavaborole", "interaction_type": 47, "interaction_text": "The metabolism of Tavaborole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "losartan", "drug2": "EFINACONAZOLE", "interaction_type": 47, "interaction_text": "The metabolism of EFINACONAZOLE can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "proguanil", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "selegiline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "glyburide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "morphine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "nimesulide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nimesulide.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "clindamycin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "histamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "formoterol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "cephalexin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "thalidomide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "quazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "dicumarol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "primidone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with primidone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "nicotine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "epinastine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "nicotine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "bupropion", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "selegiline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "busulfan", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "zonisamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "estramustine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "hesperetin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "estramustine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "estramustine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "estramustine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "quazepam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "granisetron", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "buspirone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "dolasetron", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "dolasetron", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "losartan", "drug2": "Anidulafungin", "interaction_type": 47, "interaction_text": "The metabolism of Anidulafungin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "imipramine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "losartan", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "aminophylline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "AMPHETAMINE", "interaction_type": 47, "interaction_text": "The metabolism of AMPHETAMINE can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "progesterone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "riluzole", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "estrone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with estrone.", "severity": 2}
{"drug1": "theophylline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "cytarabine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "losartan", "drug2": "butenafine", "interaction_type": 47, "interaction_text": "The metabolism of butenafine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "cytarabine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "losartan", "drug2": "5-Fluorocytosine", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorocytosine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "lomustine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "estradiol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Bivalirudin", "interaction_type": 47, "interaction_text": "The metabolism of Bivalirudin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "testosterone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "anagrelide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "cisapride", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "bepridil", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "proguanil", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "sertraline", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "astemizole", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "astemizole", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Perampanel", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "propofol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with propofol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "losartan", "drug2": "benzoic acid", "interaction_type": 47, "interaction_text": "The metabolism of benzoic acid can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "risperidone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "azelastine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "warfarin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "losartan", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with losartan.", "severity": 2}
{"drug1": "meperidine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "labetalol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "miconazole", "interaction_type": 47, "interaction_text": "The metabolism of miconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "mestranol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "clorazepate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "hesperetin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "theophylline", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "indomethacin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "BALSALAZIDE", "interaction_type": 47, "interaction_text": "The metabolism of BALSALAZIDE can be decreased when combined with azathioprine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "trazodone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Artemether", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "citalopram", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "etizolam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "finasteride", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "tretinoin", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "propafenone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with propafenone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "malathion", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with malathion.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "temazepam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "glyburide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "citalopram", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "clozapine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "citalopram", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pergolide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pergolide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "temazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "quinacrine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "malathion", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with malathion.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Letermovir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "nifedipine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with gabapentin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "trimetrexate", "interaction_type": 47, "interaction_text": "The metabolism of trimetrexate can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "felbamate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "captopril", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "proguanil", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "suprofen", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "lomustine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "letrozole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "famotidine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "famotidine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "mianserin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "efavirenz", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "timolol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "glyburide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "formoterol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "finasteride", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "clofibrate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "meperidine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "meperidine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "ipratropium", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "halothane", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "halothane", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "methyprylon", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "modafinil", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "felbamate", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "montelukast", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "loratadine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "glipizide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Dothiepin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "piperazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "PERINDOPRIL", "interaction_type": 47, "interaction_text": "The metabolism of PERINDOPRIL can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "haloprogin", "interaction_type": 47, "interaction_text": "The metabolism of haloprogin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "buspirone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "nadolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with nadolol.", "severity": 2}
{"drug1": "benztropine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "quazepam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "nicotine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "montelukast", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "montelukast", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "methadone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "carmustine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "estradiol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "azelastine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "methadone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with methadone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "promazine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with promazine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "omeprazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "donepezil", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "theophylline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "theophylline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Vemurafenib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "lidocaine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "flecainide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "ajmaline", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "loperamide", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "losartan", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "pentamidine", "interaction_type": 47, "interaction_text": "The metabolism of pentamidine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "cilostazol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Naftifine", "interaction_type": 47, "interaction_text": "The metabolism of Naftifine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "labetalol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "tolperisone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "haloperidol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "triazolam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "lidocaine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "mianserin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "vincristine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "flunisolide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "triazolam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "azelastine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "ethanol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ethanol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "propofol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with propofol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "maprotiline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Permethrin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "halothane", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "proguanil", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "tolterodine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "tolterodine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "vincristine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "astemizole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "astemizole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "niclosamide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "timolol", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "argatroban", "interaction_type": 47, "interaction_text": "The metabolism of argatroban can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Quinine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "nateglinide", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "indapamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "montelukast", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "galanthamine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "diltiazem", "drug2": "PERINDOPRIL", "interaction_type": 47, "interaction_text": "The metabolism of PERINDOPRIL can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "temazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Torasemide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "miconazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "azathioprine", "drug2": "Olsalazine", "interaction_type": 47, "interaction_text": "The metabolism of Olsalazine can be decreased when combined with azathioprine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "toremifene", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "tretinoin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with atorvastatin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "doxepin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "risperidone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "risperidone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "formoterol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "histamine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "lomustine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "proguanil", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "methadone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with methadone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "manidipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with manidipine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "bupropion", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "selegiline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Apremilast", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "mianserin", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "albendazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "albendazole", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "albendazole", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "albendazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "zidovudine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "toremifene", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "toremifene", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "terbinafine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "caffeine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "lomustine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "piperazine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "progesterone", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "finasteride", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Netupitant", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "perphenazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "desipramine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "estrone", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with estrone.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "nifedipine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "diazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "nicergoline", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "donepezil", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "cisapride", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "prazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "nabumetone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "trazodone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Quinine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "modafinil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "ambroxol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "celecoxib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "ajmaline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ajmaline", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "dolasetron", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "dolasetron", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "miconazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "felbamate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Palbociclib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "quazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "levodopa", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Encainide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Encainide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "levodopa", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "spiramycin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "clozapine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "clonidine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "loratadine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "hesperetin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "quinapril", "interaction_type": 47, "interaction_text": "The metabolism of quinapril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Encainide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "amsacrine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "teniposide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "quinacrine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "omeprazole", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "griseofulvin", "interaction_type": 47, "interaction_text": "The metabolism of griseofulvin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "trazodone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "menadione", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with menadione.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Riociguat", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "prednisone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "promazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with promazine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "theophylline", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "aspirin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "promethazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "estrone", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "theophylline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "terbinafine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "testosterone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "losartan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "mianserin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "buspirone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "losartan", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "ketamine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "glipizide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "felbamate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "estradiol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "glyburide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "glyburide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with STIRIPENTOL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "testosterone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "astemizole", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "morphine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "levodopa", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "ethanol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "labetalol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "guanabenz", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Safinamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "estradiol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "estradiol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "cocaine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "bupropion", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "pergolide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "bupropion", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "halothane", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "glyburide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "progesterone", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "progesterone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "etodolac", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Artemether", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "dantrolene", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Quinine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "timolol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Letermovir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "donepezil", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "letrozole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "sulconazole", "interaction_type": 47, "interaction_text": "The metabolism of sulconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "diltiazem", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "letrozole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "diltiazem", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "diltiazem", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "sildenafil", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "antipyrine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "mestranol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "vincristine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "raloxifene", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "warfarin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Artemether", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "dopamine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "temazepam", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "lomustine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "dapsone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "epinastine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "argatroban", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "selegiline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "clindamycin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "selegiline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "ritonavir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "selegiline", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "theobromine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Lacidipine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "toremifene", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "ajmaline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "loratadine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "estramustine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "nicotine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "estramustine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "lomustine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "proguanil", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "mestranol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "formoterol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Quinine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "tetracycline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "nicotine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "buspirone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "labetalol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "modafinil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "aminophylline", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "dapsone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "dapsone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Rivaroxaban", "interaction_type": 47, "interaction_text": "The metabolism of Rivaroxaban can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "glipizide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "morphine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "efavirenz", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "argatroban", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "cephalexin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "theophylline", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "salicylic acid", "interaction_type": 47, "interaction_text": "The metabolism of salicylic acid can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "THYMOL", "interaction_type": 47, "interaction_text": "The metabolism of THYMOL can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Encainide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "testosterone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "mestranol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "promethazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "imipramine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "cocaine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "progesterone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "bupropion", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "etoposide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "NATAMYCIN", "interaction_type": 47, "interaction_text": "The metabolism of NATAMYCIN can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Imatinib", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Arotinolol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "estrone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with estrone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "pergolide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "azelastine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "desipramine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "temazepam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "temazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "glyburide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "clozapine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "amiodarone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "dopamine", "drug2": "Tolcapone", "interaction_type": 47, "interaction_text": "The metabolism of Tolcapone can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "caffeine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "etizolam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "rapamycin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "letrozole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Permethrin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "letrozole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "letrozole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "etodolac", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "dantrolene", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "tretinoin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "propofol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "flutamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "digitoxin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "halothane", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "dapsone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "methyprylon", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "antipyrine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "isradipine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "modafinil", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "efavirenz", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "tolterodine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "citalopram", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "suprofen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "trimipramine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "trimipramine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "ketamine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "miconazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "itraconazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "nicergoline", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "nicergoline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "losartan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "alprenolol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "alprenolol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "norgestrel", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "ethanol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "resveratrol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "felbamate", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "tiagabine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "montelukast", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "montelukast", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "manidipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with manidipine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "EFINACONAZOLE", "interaction_type": 47, "interaction_text": "The metabolism of EFINACONAZOLE can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Tavaborole", "interaction_type": 47, "interaction_text": "The metabolism of Tavaborole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "calcitriol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "modafinil", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "trazodone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "dobutamine", "drug2": "Tolcapone", "interaction_type": 47, "interaction_text": "The metabolism of Tolcapone can be decreased when combined with dobutamine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "promazine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "epinastine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "enalapril", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with BOPINDOLOL.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "cephalexin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "morphine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "tazarotene", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "busulfan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "montelukast", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "primidone", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with primidone.", "severity": 2}
{"drug1": "tazarotene", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "theophylline", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "theophylline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "losartan", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with losartan.", "severity": 2}
{"drug1": "theophylline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "suprofen", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "zidovudine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "dienestrol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dienestrol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "albendazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "estrone", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with estrone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "praziquantel", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "morphine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Netupitant", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "flunisolide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "donepezil", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Dienogest", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Dienogest", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "benztropine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "theophylline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "cisapride", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Benidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Benidipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "testosterone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Encainide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "simvastatin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "theophylline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Asenapine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "labetalol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "glyburide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "sertraline", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "glyburide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "sertraline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "tolterodine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Quinine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "indinavir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "propofol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with propofol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "propofol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with propofol.", "severity": 2}
{"drug1": "sibutramine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "progesterone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "sibutramine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "astemizole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "protriptyline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "astemizole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "leflunomide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "warfarin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "promazine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Milnacipran.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "alosetron", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "norethindrone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "praziquantel", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "alosetron", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "alosetron", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "indapamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "valsartan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mitoxantrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "risperidone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "risperidone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "risperidone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "trazodone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "pergolide", "drug2": "selegiline", "interaction_type": 47, "interaction_text": "The metabolism of selegiline can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "albendazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "estazolam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "primidone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with primidone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "temazepam", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "albendazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "albendazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "albendazole", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "albendazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "doxepin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "doxepin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "nicotine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "practolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with practolol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "glipizide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "selegiline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "mebendazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "mianserin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "sertraline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "nicergoline", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "propranolol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "dopamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "granisetron", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "progesterone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "methyprylon", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Dienogest", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "temazepam", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "antipyrine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "clofibrate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "clofibrate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "clofibrate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "perphenazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "suprofen", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "formoterol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "formoterol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "quetiapine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "epinastine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "epinastine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Torasemide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Artemether", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "albendazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Anidulafungin", "interaction_type": 47, "interaction_text": "The metabolism of Anidulafungin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ranitidine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "epinastine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Encainide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunisolide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "toremifene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "toremifene", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "nicotine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "cisapride", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "pravastatin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "terbinafine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "selegiline", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "gliclazide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "famotidine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "rapamycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "leflunomide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "flunarizine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "tetracycline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "flunarizine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Melatonin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "busulfan", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "estramustine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "dapsone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "aspirin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "ketamine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "ketamine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "etizolam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "captopril", "interaction_type": 47, "interaction_text": "The metabolism of captopril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "estrone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "NATAMYCIN", "interaction_type": 47, "interaction_text": "The metabolism of NATAMYCIN can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "estrone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with estrone.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "estrone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with estrone.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Encainide", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "caffeine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "flecainide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "astemizole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "dapsone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dapsone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "moclobemide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "nilutamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "nilutamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "zidovudine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with propofol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "progesterone", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "protriptyline", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "calcitriol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "flecainide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "loperamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "halothane", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with halothane.", "severity": 2}
{"drug1": "benztropine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "naloxone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "etodolac", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "ranitidine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "timolol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "timolol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "timolol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "caffeine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "raloxifene", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "nabumetone", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "loperamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "halothane", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "astemizole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "nateglinide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Letermovir", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "cisapride", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "malathion", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with malathion.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "mianserin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "mianserin", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "sertraline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sertraline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "azithromycin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Artemether", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "miconazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "galanthamine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Artemether", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "toremifene", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "nateglinide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "estradiol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "naloxone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "theophylline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "risperidone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Macitentan", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "histamine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "ketamine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with gabapentin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "pergolide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "mebendazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "pergolide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "albendazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "formoterol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "tazarotene", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "zidovudine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "temazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "codeine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with codeine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "propranolol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "histamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "piperazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "propofol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "risperidone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "terbinafine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "ketamine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "nicergoline", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "buspirone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "clonazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "quazepam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "spiramycin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "nicotine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "menadione", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with menadione.", "severity": 2}
{"drug1": "alprenolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "prazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "raloxifene", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Quinine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "metronidazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "letrozole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "ondansetron", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "dolasetron", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "morphine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "quazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "primidone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with primidone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "ambroxol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "prazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "amsacrine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "erythromycin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tinidazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "quazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "tioconazole", "interaction_type": 47, "interaction_text": "The metabolism of tioconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "vinblastine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "quetiapine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "caffeine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "azelastine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "thiabendazole", "interaction_type": 47, "interaction_text": "The metabolism of thiabendazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "quinidine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "alosetron", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "ketamine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "ajmaline", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "zidovudine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "theophylline", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "haloperidol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "theophylline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "lidocaine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "losartan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with losartan.", "severity": 2}
{"drug1": "losartan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "pentamidine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "promethazine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "labetalol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "labetalol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "labetalol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "flutamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "nicotine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "glyburide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "felbamate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "zidovudine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Quinine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "etizolam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "etizolam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "testosterone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "risperidone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "propofol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "ethanol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "testosterone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "testosterone", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "estradiol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "diclofenac", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Neratinib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "halothane", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "methyprylon", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "methyprylon", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "methyprylon", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "timolol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with timolol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "mebendazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "montelukast", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "glipizide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "loratadine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "codeine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with codeine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "losartan", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "captopril", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "alosetron", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "lomustine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "propranolol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "granisetron", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "duloxetine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Risedronic acid.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "busulfan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "nicotine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "proguanil", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "isradipine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "flutamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "loperamide", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "bupropion", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "captopril", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "zolpidem", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "omeprazole", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "omeprazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "nicotine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "flecainide", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "buspirone", "drug2": "cerulenin", "interaction_type": 47, "interaction_text": "The metabolism of cerulenin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dapsone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "naloxone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "modafinil", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "bupropion", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "aminophylline", "drug2": "sparfloxacin", "interaction_type": 47, "interaction_text": "The metabolism of sparfloxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "estrone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with estrone.", "severity": 2}
{"drug1": "nadolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with nadolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "riluzole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "tiagabine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "domperidone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "estrone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with estrone.", "severity": 2}
{"drug1": "domperidone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "finasteride", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "cephalexin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "nicotine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "losartan", "drug2": "miconazole", "interaction_type": 47, "interaction_text": "The metabolism of miconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "losartan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "morphine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "benztropine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "etoposide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "etoposide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "clindamycin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "ambroxol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "ajmaline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "etoposide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "clonidine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "clonidine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Encainide", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "benztropine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "teniposide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "menadione", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with menadione.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "theophylline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "promethazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "cytarabine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "etoposide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "glyburide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "glyburide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "glyburide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "donepezil", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "quetiapine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "promazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "carmustine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "mestranol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "ketamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "donepezil", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "propofol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "vincristine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Macitentan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "risperidone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "donepezil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Letermovir", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "donepezil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Letermovir", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "imipramine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "estrone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "ranitidine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "doxepin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "probenecid", "interaction_type": 47, "interaction_text": "The metabolism of probenecid can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "temazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "clozapine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "etoposide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "dopamine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "dopamine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "pergolide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "dantrolene", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "aspirin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "propofol", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "mianserin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "azithromycin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "piperazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "progesterone", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "dolasetron", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "desipramine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "glucosamine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "loperamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "olanzapine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "quazepam", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "loratadine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "meperidine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Remikiren", "interaction_type": 47, "interaction_text": "The metabolism of Remikiren can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "captopril", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "piperazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "glipizide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "glipizide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "proguanil", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "morphine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Artemether", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Quinine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Artemether", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "finasteride", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "selegiline", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "mefloquine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Quinine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "perphenazine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "aminophylline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "montelukast", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "benztropine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "benztropine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "quazepam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "proguanil", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "histamine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with histamine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "mequitazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "argatroban", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "bupropion", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "histamine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with histamine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "omeprazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Neratinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "cephalexin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "buspirone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "buspirone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "halothane", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with halothane.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "teniposide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Encainide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Apremilast", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "bupropion", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "etoposide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "etoposide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Melatonin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "finasteride", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "loratadine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "busulfan", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "morphine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "dapsone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "methadone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "miconazole", "interaction_type": 47, "interaction_text": "The metabolism of miconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "progesterone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Asunaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Asunaprevir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "vinblastine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "thalidomide", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ajmaline", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "sertraline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "meperidine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "morphine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with morphine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Quinine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "flecainide", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "flecainide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Dienogest", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Dienogest", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "teniposide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "etizolam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "morphine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with morphine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "diazepam", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "nilutamide", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "astemizole", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "dopamine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "amprenavir", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "dopamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "leflunomide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "diltiazem", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "risperidone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Quinine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "azelastine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "propofol", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "miconazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "timolol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "histamine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with histamine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "nicotine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "alosetron", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "irbesartan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "amoxapine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "montelukast", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "norethindrone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "indapamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "enalapril", "interaction_type": 47, "interaction_text": "The metabolism of enalapril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "olanzapine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "norethindrone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "ritonavir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "risperidone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Artemether", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "azelastine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "azelastine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "azelastine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "doxepin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "codeine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "flutamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "azelastine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with sumatriptan.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "mianserin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "captopril", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with captopril.", "severity": 2}
{"drug1": "loperamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "glipizide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "proguanil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "piperazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "propranolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "ritonavir", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "proguanil", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "cisapride", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "prednisone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "oxycodone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "raloxifene", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "loratadine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "nicotine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "amprenavir", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "astemizole", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "nateglinide", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "ROSOXACIN", "interaction_type": 47, "interaction_text": "The metabolism of ROSOXACIN can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "progesterone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "meperidine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "tretinoin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "meperidine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "ipratropium", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "finasteride", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "caffeine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "suprofen", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "meperidine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "etoposide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "caffeine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "buspirone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "morphine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nimesulide.", "severity": 2}
{"drug1": "nicotine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "practolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with practolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "indinavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "levodopa", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "alosetron", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "thiotepa", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "zopiclone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "thiotepa", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "disulfiram", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "temazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "flunarizine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "menadione", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with menadione.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "bepridil", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "busulfan", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Boceprevir.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "vinblastine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "theophylline", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "tinidazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "cocaine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "suprofen", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "digoxin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "aspirin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "zidovudine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "promazine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "nystatin", "interaction_type": 47, "interaction_text": "The metabolism of nystatin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "lomustine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "5-Fluorocytosine", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorocytosine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "riluzole", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "butenafine", "interaction_type": 47, "interaction_text": "The metabolism of butenafine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "domperidone", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "amsacrine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "proguanil", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "estrone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "digoxin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "flecainide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "felodipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "testosterone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "nilutamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "testosterone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "testosterone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "testosterone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "sulconazole", "interaction_type": 47, "interaction_text": "The metabolism of sulconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "etoposide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "ranitidine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "Perampanel", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "anagrelide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "bupropion", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "dopamine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "dopamine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "warfarin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "propofol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "caffeine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Axitinib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "glyburide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "astemizole", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "loperamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "clonazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "propofol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "proguanil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "caffeine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "sertraline", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "albendazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Micafungin", "interaction_type": 47, "interaction_text": "The metabolism of Micafungin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "quinidine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "Imatinib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "tretinoin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "ketamine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "clonidine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "menadione", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with menadione.", "severity": 2}
{"drug1": "selegiline", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "glipizide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "malathion", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "zidovudine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Milnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Milnacipran can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "tetracycline", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "amprenavir", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "pergolide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "quinacrine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "morphine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with morphine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "nicotine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Miltefosine", "interaction_type": 47, "interaction_text": "The metabolism of Miltefosine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "letrozole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "progesterone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "alosetron", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "famotidine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "progesterone", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "dapsone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "dapsone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "caffeine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "methyprylon", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "prazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "loratadine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "loperamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "loratadine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "morphine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with morphine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "epinastine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "naloxone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "suprofen", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "epinastine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "alosetron", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "prazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "argatroban", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "dapsone", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "cisapride", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "quazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "quazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "quazepam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Riociguat", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "teniposide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "teniposide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "clofazimine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "mequitazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "finasteride", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "cisapride", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "haloperidol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "zonisamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "mefloquine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "azelastine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Melatonin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "teniposide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "promazine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "prazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "thalidomide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "warfarin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "flecainide", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "flecainide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with Arotinolol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "losartan", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with losartan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "galanthamine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "losartan", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with losartan.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "lomustine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "albendazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Letermovir", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Lacidipine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "nicotine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with Bevantolol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "glucosamine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "formoterol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "astemizole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "ranitidine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "maprotiline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "felodipine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "halothane", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "bepridil", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "ropinirole", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "methyprylon", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "progesterone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Neratinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Neratinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "piperazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Isoflurophate", "interaction_type": 47, "interaction_text": "The metabolism of Isoflurophate can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "pergolide", "drug2": "isocarboxazid", "interaction_type": 47, "interaction_text": "The metabolism of isocarboxazid can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Tramadol", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "dyphylline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "chloroquine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "benztropine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "timolol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "captopril", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with captopril.", "severity": 2}
{"drug1": "finasteride", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "felbamate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "proguanil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "codeine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with codeine.", "severity": 2}
{"drug1": "proguanil", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "glimepiride", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "piperazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "methadone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with methadone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "pergolide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "albendazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "albendazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "citalopram", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "halothane", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with halothane.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "formoterol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "captopril", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with captopril.", "severity": 2}
{"drug1": "toremifene", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "omeprazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "amprenavir", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "histamine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with histamine.", "severity": 2}
{"drug1": "estramustine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "montelukast", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "nicotine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "pimozide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "quinidine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "diazepam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "diazepam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "glimepiride", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "meperidine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Encainide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Encainide", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "sulfinpyrazone", "interaction_type": 47, "interaction_text": "The metabolism of sulfinpyrazone can be decreased when combined with phenindione.", "severity": 2}
{"drug1": "cisapride", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "cisapride", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "cephalexin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "cephalexin", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "nabumetone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "alprenolol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Quinine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "etoposide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "citalopram", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "loratadine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "thiotepa", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "ajmaline", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "estrone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "hesperetin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "hesperetin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "hesperetin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "Encainide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "glyburide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "glyburide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "triamterene", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "flunarizine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "sibutramine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "rapamycin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "celiprolol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "clozapine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Escitalopram", "interaction_type": 47, "interaction_text": "The metabolism of Escitalopram can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "theophylline", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "clozapine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "azelastine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "losartan", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "losartan", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "mianserin", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "alclometasone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "mianserin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "testosterone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "ketamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "bupropion", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "benztropine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "indapamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "ketamine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "estazolam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "estazolam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "estradiol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "midazolam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "famotidine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "proguanil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "ondansetron", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Axitinib", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "albendazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "azelastine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "dapsone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Quinine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "bupropion", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "meperidine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "meperidine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "progesterone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "loperamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "loperamide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "glucosamine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "loperamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "bupropion", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "warfarin", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "loperamide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "flutamide", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "timolol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with timolol.", "severity": 2}
{"drug1": "propofol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "zaleplon", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diltiazem", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "propranolol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "propranolol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "etodolac", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "enalapril", "interaction_type": 47, "interaction_text": "The metabolism of enalapril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "raloxifene", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "raloxifene", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Artemether", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "dolasetron", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Quinine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "selegiline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "diazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "docetaxel", "interaction_type": 47, "interaction_text": "The metabolism of docetaxel can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "montelukast", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "montelukast", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "montelukast", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "epinastine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "nicotine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "clindamycin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "thiotepa", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "dicumarol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "dicumarol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "flutamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "montelukast", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "mestranol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "estramustine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "butenafine", "interaction_type": 47, "interaction_text": "The metabolism of butenafine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "5-Fluorocytosine", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorocytosine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "methadone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with methadone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "dantrolene", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "piperazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "busulfan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "amsacrine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "doxepin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "suprofen", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "cytarabine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "naloxone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "ajmaline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "dapsone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Encainide", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "flecainide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "losartan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "donepezil", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "morphine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "morphine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "morphine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "glipizide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "glucosamine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "theophylline", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "mianserin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "quinidine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "suprofen", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "Dienogest", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Capsaicin", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Capsaicin.", "severity": 2}
{"drug1": "Artemether", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "estradiol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "clonidine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "progesterone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "risperidone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "estradiol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "loperamide", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "bupropion", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "ondansetron", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Imatinib", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "estrone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with estrone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "astemizole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Imatinib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Letermovir", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Letermovir", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "quinidine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "danazol", "interaction_type": 47, "interaction_text": "The metabolism of danazol can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "riluzole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Lacidipine.", "severity": 2}
{"drug1": "triamterene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "doxepin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "doxepin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "sulfinpyrazone", "interaction_type": 47, "interaction_text": "The metabolism of sulfinpyrazone can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "glipizide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "azelastine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "risperidone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "doxepin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "indapamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "flutamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "desipramine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "estradiol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "malathion", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "malathion", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with malathion.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "malathion", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "proguanil", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with sumatriptan.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "mianserin", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "granisetron", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cisapride", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "propranolol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "buspirone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "progesterone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "methyprylon", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "citalopram", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "celiprolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "cephalexin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "loratadine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "clonidine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zonisamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Encainide", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "4-aminopyridine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with 4-aminopyridine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "dapsone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "itraconazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "dapsone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "halothane", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "ipratropium", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "desipramine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "ambroxol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "paroxetine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "indapamide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "halothane", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "tiagabine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Remikiren", "interaction_type": 47, "interaction_text": "The metabolism of Remikiren can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "celecoxib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "loratadine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "timolol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with timolol.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "mebendazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "quazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "methadone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with methadone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "flutamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "lomustine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "alosetron", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "meprobamate", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "pergolide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "docetaxel", "drug2": "nystatin", "interaction_type": 47, "interaction_text": "The metabolism of nystatin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "nicotine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "loratadine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "bupropion", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Artemether", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "docetaxel", "drug2": "miconazole", "interaction_type": 47, "interaction_text": "The metabolism of miconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "diazepam", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "meperidine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "dolasetron", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "promazine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "ipratropium", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "dapsone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "doxepin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "loperamide", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "clonidine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "busulfan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "riluzole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "ambroxol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "loperamide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "theophylline", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "alclometasone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "donepezil", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "flunisolide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "benztropine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "benztropine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "benztropine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "dopamine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "timolol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with timolol.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "ethanol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "trazodone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "lomustine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "warfarin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ropinirole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "propofol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with propofol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "cephalexin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "clofazimine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Axitinib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "glyburide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "bepridil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Axitinib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "bepridil", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "sibutramine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Neratinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "azelastine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "azelastine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "timolol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "caffeine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "timolol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with timolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Quinine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "halothane", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with halothane.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Conivaptan.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "etodolac", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "flunarizine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "norgestrel", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "Torasemide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Ecabet", "interaction_type": 47, "interaction_text": "The metabolism of Ecabet can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "alosetron", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "alosetron", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "captopril", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "risperidone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "risperidone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "etizolam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Artemether", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Artemether", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "zidovudine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "alosetron", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "theobromine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "doxepin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "histamine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with histamine.", "severity": 2}
{"drug1": "nicotine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "nateglinide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "toremifene", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "tetracycline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "midazolam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "desipramine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "zidovudine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "diazepam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "niclosamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "diazepam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "piperazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "piperazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "proguanil", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "nicergoline", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with diethylstilbestrol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "clonazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "niclosamide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "albendazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "diazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "finasteride", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with Nebivolol.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "bepridil", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "suprofen", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "granisetron", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "argatroban", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "aspirin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "cocaine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "nabumetone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "naloxone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "flutamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "estrone", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "flunisolide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "levodopa", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "hesperetin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "amsacrine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "theophylline", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Gemifloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Gemifloxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "perphenazine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "doxepin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "indinavir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "Perospirone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "teniposide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "clozapine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "halothane", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with halothane.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pimozide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "promethazine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Amrinone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Amrinone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "selegiline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "estramustine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "estramustine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "prednisone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "morphine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "donepezil", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "caffeine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "promethazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Enalaprilat", "interaction_type": 47, "interaction_text": "The metabolism of Enalaprilat can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "simvastatin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "thioguanine", "drug2": "Olsalazine", "interaction_type": 47, "interaction_text": "The metabolism of Olsalazine can be decreased when combined with thioguanine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "warfarin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "azelastine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "epinastine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "carmustine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "loratadine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "bupropion", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "quinidine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "hesperetin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "donepezil", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "histamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with histamine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "estrone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with estrone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "aspirin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "aspirin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "loratadine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "quinidine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "ajmaline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "promazine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "promazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "progesterone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "estradiol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "glucosamine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "estradiol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "dopamine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "mequitazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "timolol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with timolol.", "severity": 2}
{"drug1": "calcitriol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "formoterol", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "risperidone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "risperidone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "halothane", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with halothane.", "severity": 2}
{"drug1": "benztropine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "halothane", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "progesterone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "progesterone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "antipyrine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "imipramine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "celecoxib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "halothane", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nateglinide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "sertraline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "lomustine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "doxazosin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "losartan", "drug2": "Isoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Isoconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with secobarbital.", "severity": 2}
{"drug1": "pergolide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "sertraline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "sertraline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "codeine", "drug2": "SOMATOSTATIN", "interaction_type": 47, "interaction_text": "The metabolism of SOMATOSTATIN can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "quinidine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "teniposide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "propranolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "piperazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "methadone", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Riociguat", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "pergolide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "tretinoin", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "bifonazole", "interaction_type": 47, "interaction_text": "The metabolism of bifonazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "histamine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with histamine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "formoterol", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "histamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "thioridazine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "formoterol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "captopril", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with captopril.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "azithromycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "buspirone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "isradipine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "epinastine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "terbinafine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "antipyrine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "levodopa", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "morphine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "morphine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Isoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Isoconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "cephalexin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "histamine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Quinine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "ambroxol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "morphine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with morphine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "morphine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "erythromycin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "erythromycin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "atenolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with atenolol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "prazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "estrone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "clonidine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "bifonazole", "interaction_type": 47, "interaction_text": "The metabolism of bifonazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Pinaverium.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "imipramine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "granisetron", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "etoposide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "etoposide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Butoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Butoconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "carmustine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "lidocaine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "enalapril", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "tinidazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "azelastine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "promazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with promazine.", "severity": 2}
{"drug1": "azelastine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "cerulenin", "interaction_type": 47, "interaction_text": "The metabolism of cerulenin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "donepezil", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "aminophylline", "drug2": "LEVOFLOXACIN", "interaction_type": 47, "interaction_text": "The metabolism of LEVOFLOXACIN can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "meperidine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "estrone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with estrone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "glipizide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "valsartan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "zidovudine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "azelastine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "miconazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "diclofenac", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "norethindrone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "diclofenac", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "temazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "malathion", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "malathion", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "halothane", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with halothane.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Encainide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "glipizide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "nicotine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "praziquantel", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Alogliptin", "interaction_type": 47, "interaction_text": "The metabolism of Alogliptin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "risperidone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "proguanil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "letrozole", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "letrozole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "propranolol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "testosterone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "dopamine", "drug2": "testosterone propionate", "interaction_type": 47, "interaction_text": "The metabolism of testosterone propionate can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "labetalol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "loperamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "estradiol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "terbinafine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "loperamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "timolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "argatroban", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "halothane", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with halothane.", "severity": 2}
{"drug1": "mestranol", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "sildenafil", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "meperidine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "antipyrine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "morphine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "captopril", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with captopril.", "severity": 2}
{"drug1": "paroxetine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "paroxetine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "finasteride", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Artemether", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "levodopa", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "teniposide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "montelukast", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Coenzyme Q10.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "meprobamate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "nicotine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "thiotepa", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "famciclovir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "famciclovir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "selegiline", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "mianserin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "tretinoin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "nilutamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "practolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with practolol.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "amprenavir", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "olanzapine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "ethanol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "citalopram", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "alprenolol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "flunarizine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "histamine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Artemether", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "imipramine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "niclosamide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "buspirone", "drug2": "tioconazole", "interaction_type": 47, "interaction_text": "The metabolism of tioconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "amsacrine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "captopril", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with captopril.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "digitoxin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Enalaprilat", "interaction_type": 47, "interaction_text": "The metabolism of Enalaprilat can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "dobutamine", "drug2": "testosterone propionate", "interaction_type": 47, "interaction_text": "The metabolism of testosterone propionate can be decreased when combined with dobutamine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "aminophylline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "domperidone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "histamine", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "losartan", "drug2": "Micafungin", "interaction_type": 47, "interaction_text": "The metabolism of Micafungin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "benztropine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "aminophylline", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "levodopa", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "doxazosin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "modafinil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Dienogest", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Dienogest", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "glyburide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "triamterene", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "pravastatin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "clonidine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "amoxapine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "promethazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "leflunomide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "norgestrel", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "timolol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "propofol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "clindamycin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "sertraline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "mestranol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with cilnidipine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Dabrafenib.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "codeine", "drug2": "Lanreotide", "interaction_type": 47, "interaction_text": "The metabolism of Lanreotide can be decreased when combined with codeine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Macitentan", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Macitentan", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "valsartan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "theophylline", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "promazine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "promazine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "tolterodine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Artemether", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Letermovir", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Letermovir", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "lidocaine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "lidocaine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "azelastine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "dicumarol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "clomipramine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "propofol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "quinidine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "mianserin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "clozapine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "procarbazine", "interaction_type": 47, "interaction_text": "The metabolism of procarbazine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "progesterone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "progesterone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "amprenavir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "cisapride", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "mianserin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "propofol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "amprenavir", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "midazolam", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "zolpidem", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "loratadine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "estrone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "amiodarone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "lomustine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "formoterol", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "diltiazem", "drug2": "quinapril", "interaction_type": 47, "interaction_text": "The metabolism of quinapril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "ipratropium", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "trimipramine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "diclofenac", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "desipramine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "formoterol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "loratadine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "trimipramine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "diltiazem", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "meperidine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "suprofen", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "suprofen", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "naloxone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "alosetron", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "toremifene", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "toremifene", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "toremifene", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "toremifene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Artemether", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Artemether", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Artemether", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "flutamide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "diltiazem", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "montelukast", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Palbociclib.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "histamine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "warfarin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "isradipine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Efonidipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "dyphylline", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "quazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "granisetron", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "argatroban", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "argatroban", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "nicotine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "rapamycin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "thalidomide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "acebutolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with acebutolol.", "severity": 2}
{"drug1": "formoterol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "selegiline", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "selegiline", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "estramustine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "granisetron", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Encainide", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "buspirone", "drug2": "terconazole", "interaction_type": 47, "interaction_text": "The metabolism of terconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "buspirone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "glucosamine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "etoposide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "ketamine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Palbociclib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "estrone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "vinblastine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "estrone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with estrone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "flecainide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "ambroxol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "dapsone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dapsone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "dapsone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "montelukast", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "guanabenz", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "mianserin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "dopamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "testosterone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "formoterol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "testosterone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "meperidine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "propofol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "sibutramine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with Metipranolol.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "dopamine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Efonidipine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "estradiol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "halothane", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "risperidone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "halothane", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with halothane.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "halothane", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "progesterone", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "progesterone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "tolterodine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "nateglinide", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "caffeine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "miconazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "mianserin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "cerulenin", "interaction_type": 47, "interaction_text": "The metabolism of cerulenin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "timolol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "enflurane", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with enflurane.", "severity": 2}
{"drug1": "halothane", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "cilostazol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "theophylline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "dyphylline", "drug2": "fleroxacin", "interaction_type": 47, "interaction_text": "The metabolism of fleroxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "ritonavir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "granisetron", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "zolpidem", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "histamine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "histamine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "formoterol", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "codeine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with codeine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "nicotine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "cisapride", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "thioguanine", "drug2": "BALSALAZIDE", "interaction_type": 47, "interaction_text": "The metabolism of BALSALAZIDE can be decreased when combined with thioguanine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "mianserin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "formoterol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "cisapride", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "diazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "propofol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "triazolam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "tiagabine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "histamine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with histamine.", "severity": 2}
{"drug1": "nicotine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "proguanil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "letrozole", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "amprenavir", "interaction_type": 47, "interaction_text": "The metabolism of amprenavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "letrozole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "niclosamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "dapsone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "spiramycin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "loratadine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "morphine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with morphine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "mesalamine", "interaction_type": 47, "interaction_text": "The metabolism of mesalamine can be decreased when combined with azathioprine.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "formoterol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "granisetron", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "granisetron", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "granisetron", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "epinastine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "cocaine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "diazepam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "finasteride", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "levodopa", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Torasemide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "loperamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "clindamycin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "clindamycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "piperazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "ethanol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "nicotine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "nicotine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "formoterol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "digoxin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "disulfiram", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "alprenolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "disulfiram", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "quazepam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "quazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "methadone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with methadone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "alosetron", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "labetalol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "zonisamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "tinidazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "loratadine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "promazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "vinblastine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Micafungin", "interaction_type": 47, "interaction_text": "The metabolism of Micafungin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "suprofen", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "aminophylline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Cilastatin", "interaction_type": 47, "interaction_text": "The metabolism of Cilastatin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "ketamine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "triamterene", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "flecainide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "testosterone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "felodipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "ethanol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ethanol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "estradiol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "progesterone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "Perampanel", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "zidovudine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "propofol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with propofol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "quazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "carvedilol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "praziquantel", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "ropinirole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "oxycodone", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "caffeine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "chloroquine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "ranitidine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "loperamide", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "loperamide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "glipizide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "labetalol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "loperamide", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "morphine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with morphine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "sertraline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "albendazole", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "losartan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with losartan.", "severity": 2}
{"drug1": "clofibrate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Isoflurophate", "interaction_type": 47, "interaction_text": "The metabolism of Isoflurophate can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "temazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "dopamine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "famciclovir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "famciclovir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Letermovir", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "donepezil", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "donepezil", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "alosetron", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "temazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "calcitriol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "temazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Ximelagatran", "interaction_type": 47, "interaction_text": "The metabolism of Ximelagatran can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "albendazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "theobromine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "granisetron", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "granisetron", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "haloperidol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "timolol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with timolol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "felbamate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "amprenavir", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "tazarotene", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "amprenavir", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "captopril", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with captopril.", "severity": 2}
{"drug1": "cisapride", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "dapsone", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "terbinafine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "cisapride", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "thalidomide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "midazolam", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "omeprazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "cephalexin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "nateglinide", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nicotine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "loratadine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "ajmaline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "methadone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with methadone.", "severity": 2}
{"drug1": "morphine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Dienogest", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Dienogest", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "clonidine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "benztropine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "clonidine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "testosterone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "clonidine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "epinastine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "enalapril", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "pimozide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "cocaine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "Netupitant", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "enalapril", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "enalapril", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "etoposide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "domperidone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "zonisamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "teniposide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "teniposide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "granisetron", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "proguanil", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "glipizide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "azelastine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "imipramine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "azelastine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "azelastine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "busulfan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "clindamycin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "azelastine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "proguanil", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "haloperidol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "donepezil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "captopril", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with captopril.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "finasteride", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "bepridil", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "aspirin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "prazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "malathion", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with malathion.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Lacidipine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with mitoxantrone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "galanthamine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "lidocaine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "famotidine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "estrone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "estrone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with estrone.", "severity": 2}
{"drug1": "temazepam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "mianserin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "dopamine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "estazolam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "ketamine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "halothane", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "etoposide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "nicotine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "etizolam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Permethrin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "codeine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with codeine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "ropinirole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "dantrolene", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "amprenavir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "astemizole", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "astemizole", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "bromazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "loperamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "warfarin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "loperamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Miltefosine", "interaction_type": 47, "interaction_text": "The metabolism of Miltefosine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "halothane", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "halothane", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with halothane.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "halothane", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "mestranol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "mestranol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "metronidazole", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "metronidazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "methadone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "antipyrine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Remikiren", "interaction_type": 47, "interaction_text": "The metabolism of Remikiren can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "celecoxib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "loperamide", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "loperamide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "prednisone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "terbinafine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "argatroban", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "diclofenac", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "albendazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Quinine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "temazepam", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "diazepam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "clozapine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "diazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "toremifene", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "nicotine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "modafinil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "selegiline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tiagabine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "histamine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with histamine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "quazepam", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Perospirone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "busulfan", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "isradipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "alprenolol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "formoterol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "promazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "bupropion", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "progesterone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "histamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with histamine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "tolterodine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "montelukast", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "cisapride", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "vinblastine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "vinblastine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "mebendazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "ajmaline", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Encainide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "donepezil", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "mequitazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Encainide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "benztropine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "aminophylline", "drug2": "thiabendazole", "interaction_type": 47, "interaction_text": "The metabolism of thiabendazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "etoposide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "glyburide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "levodopa", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with cilnidipine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "testosterone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Encainide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cilnidipine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "testosterone", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "rapamycin", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "flecainide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "etizolam", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "imipramine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "naloxone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "montelukast", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "zonisamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "theobromine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "carmustine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "letrozole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "timolol", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "olanzapine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Macitentan", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Aprepitant", "interaction_type": 47, "interaction_text": "The metabolism of Aprepitant can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "mianserin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "tolterodine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Riociguat", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "selegiline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "bepridil", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Pregabalin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "caffeine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ombitasvir.", "severity": 2}
{"drug1": "nevirapine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "progesterone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "doxepin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "donepezil", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "glipizide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "azelastine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "lidocaine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "losartan", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with losartan.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "temazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "mianserin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "propofol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "glipizide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "triazolam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "granisetron", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "proguanil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Axitinib", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "captopril", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "captopril", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with captopril.", "severity": 2}
{"drug1": "captopril", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with captopril.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "estazolam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "estazolam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "resveratrol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "estazolam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "estazolam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "midazolam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "letrozole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "nicotine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Isoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Isoconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "piperazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "piperazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "piperazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "dapsone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "dopamine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "mestranol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "mestranol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "tretinoin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Safinamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "glucosamine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "tolterodine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "finasteride", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "trimipramine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ketamine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "etoposide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "timolol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "dolasetron", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "meperidine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "efavirenz", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "dyphylline", "drug2": "norfloxacin", "interaction_type": 47, "interaction_text": "The metabolism of norfloxacin can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "losartan", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with losartan.", "severity": 2}
{"drug1": "mebendazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Bivalirudin", "interaction_type": 47, "interaction_text": "The metabolism of Bivalirudin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "clindamycin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "terbinafine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "morphine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "ranitidine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "quazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Quinine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "indinavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "granisetron", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "thiothixene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Axitinib", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "quazepam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "disulfiram", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "calcitriol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "primidone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with primidone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Vildagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Vildagliptin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "bupropion", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "nicotine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "methadone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with methadone.", "severity": 2}
{"drug1": "nicotine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "formoterol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "flutamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "selegiline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "calcitriol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "perphenazine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "cephalexin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "bepridil", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "buspirone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "amsacrine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "buspirone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "methadone", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with methadone.", "severity": 2}
{"drug1": "aspirin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "thiopental", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with thiopental.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "imipramine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "estramustine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "progesterone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "riluzole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "salicylic acid", "interaction_type": 47, "interaction_text": "The metabolism of salicylic acid can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "selegiline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "estrone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Perampanel", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "cytarabine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "primidone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with primidone.", "severity": 2}
{"drug1": "ethanol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "dapsone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "glipizide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "felodipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "flecainide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "felodipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "theophylline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "felodipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "testosterone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "testosterone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "anagrelide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "anagrelide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "anagrelide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "promazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Netupitant", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "cocaine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "sertraline", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sibutramine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "carmustine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "estradiol", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "glyburide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "doxepin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Neratinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "azelastine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "dopamine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "progesterone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "benztropine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "warfarin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "vincristine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "warfarin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "temazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with ESMOLOL.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Artemether", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "propranolol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "bepridil", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "bepridil", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "donepezil", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "donepezil", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "valsartan", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "norethindrone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "dopamine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "protriptyline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "theophylline", "drug2": "enoxacin", "interaction_type": 47, "interaction_text": "The metabolism of enoxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "etizolam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "riluzole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "ritonavir", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "chloroquine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "temazepam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "temazepam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "clozapine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "azithromycin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "estradiol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "flutamide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pergolide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "pergolide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "midazolam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "clomipramine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "codeine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with codeine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "citalopram", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "terbinafine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Letermovir", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "astemizole", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "mianserin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "nicotine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "letrozole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "letrozole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "quetiapine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "progesterone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "nicotine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "itraconazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "itraconazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "terbinafine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Apixaban", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "quetiapine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "astemizole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "nicotine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "alosetron", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "sildenafil", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "diazepam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "naloxone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "meperidine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "ipratropium", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "dapsone", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "halothane", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "dapsone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "prazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "loratadine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "flutamide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "nilutamide", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Netupitant", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "teniposide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "teniposide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "benzoic acid", "interaction_type": 47, "interaction_text": "The metabolism of benzoic acid can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "gliclazide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "imipramine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "methadone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "cephalexin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "flutamide", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "quazepam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "resveratrol", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "thiotepa", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "flutamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "naloxone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "promazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "clonidine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "methadone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "nicardipine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Melatonin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "donepezil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "omeprazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "theophylline", "drug2": "LEVOFLOXACIN", "interaction_type": 47, "interaction_text": "The metabolism of LEVOFLOXACIN can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "theophylline", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "dapsone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "clonidine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "aspirin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "thalidomide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "etoposide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "teniposide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "aspirin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "labetalol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "mifepristone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mifepristone.", "severity": 2}
{"drug1": "tolperisone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "clomipramine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "glyburide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "dolasetron", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "etizolam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "felodipine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "testosterone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "flurazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "clonidine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "labetalol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "praziquantel", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "dopamine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "triazolam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "astemizole", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "clonidine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "propofol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "flunarizine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "flunarizine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "astemizole", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Neratinib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "glyburide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "cocaine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "bepridil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "loperamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "loperamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "amoxapine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "halothane", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "ipratropium", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "halothane", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with halothane.", "severity": 2}
{"drug1": "miconazole", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "methyprylon", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "vincristine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "glyburide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "theophylline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "triamterene", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "celiprolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "ipratropium", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "halothane", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "propranolol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "risperidone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "temazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "maprotiline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Artemether", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "diltiazem", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "diazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "captopril", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "risperidone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "captopril", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "risperidone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "risperidone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "nicotine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "anagrelide", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "lomustine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "albendazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "sertraline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "albendazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "labetalol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "albendazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "albendazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "doxepin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "histamine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with histamine.", "severity": 2}
{"drug1": "domperidone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "zidovudine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "bupropion", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "enalapril", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "carvedilol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "piperazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "nicotine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "proguanil", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "ondansetron", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "antipyrine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sulfinpyrazone", "interaction_type": 47, "interaction_text": "The metabolism of sulfinpyrazone can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "felodipine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "diazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Artemether", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "propranolol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "diltiazem", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "prazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "indapamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "cisapride", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "diazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "finasteride", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "paroxetine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "Quinine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "meperidine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "donepezil", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "morphine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with morphine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "morphine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "suprofen", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "suprofen", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "morphine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with morphine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "testosterone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "spiramycin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "cisapride", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "gliclazide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "timolol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with timolol.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "diclofenac", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "quazepam", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "methadone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with methadone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "estramustine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "azelastine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "caffeine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "prednisone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "dopamine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Micafungin", "interaction_type": 47, "interaction_text": "The metabolism of Micafungin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "bepridil", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Quinine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "menadione", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with menadione.", "severity": 2}
{"drug1": "thiotepa", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "lomustine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "chloroquine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "cocaine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "warfarin", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "quinidine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "donepezil", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "thalidomide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "doxepin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "estrone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "estrone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "progesterone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "estrone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "mianserin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "digoxin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "aspirin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "felbamate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "cilostazol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "ketamine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "felbamate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ketamine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "estazolam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "estazolam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "methadone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "warfarin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "glyburide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "ethanol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with tolfenamic acid.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "clozapine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "ethanol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "quinacrine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "glipizide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "estradiol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "prednisone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "estradiol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "amprenavir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "amprenavir", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "oxycodone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "desipramine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Macitentan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "halothane", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "letrozole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Asenapine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "folic acid", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with folic acid.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "promethazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with thiabendazole.", "severity": 2}
{"drug1": "propranolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "metronidazole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "loratadine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "meperidine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "vincristine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "vinblastine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "cisapride", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "nateglinide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "famotidine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "formoterol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "alosetron", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "lomustine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "lomustine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "argatroban", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "naloxone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "morphine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with morphine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "nicotine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "bupropion", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "nicotine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "trimipramine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "selegiline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "theobromine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "morphine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with morphine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "formoterol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Azelnidipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "flutamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "cisapride", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "flutamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "flutamide", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "mebendazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "thiotepa", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "thiotepa", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "celecoxib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Apixaban", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Apixaban", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "flunarizine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "histamine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "loperamide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "formoterol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "captopril", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with captopril.", "severity": 2}
{"drug1": "simvastatin", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "azithromycin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "montelukast", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "quinidine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "haloprogin", "interaction_type": 47, "interaction_text": "The metabolism of haloprogin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Melatonin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "diazepam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "modafinil", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "modafinil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Tianeptine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "oxazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "suprofen", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "suprofen", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "alprenolol", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "nicotine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "losartan", "drug2": "cerulenin", "interaction_type": 47, "interaction_text": "The metabolism of cerulenin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "meperidine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "levodopa", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "erythromycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "erythromycin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "etoposide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "benztropine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "quazepam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "clonidine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "naloxone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "prazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "propofol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "imipramine", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "imipramine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "glyburide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "glyburide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "quazepam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "hexetidine", "interaction_type": 47, "interaction_text": "The metabolism of hexetidine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "mestranol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "mestranol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "azelastine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "theophylline", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "cytarabine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "risperidone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "aminophylline", "drug2": "ROSOXACIN", "interaction_type": 47, "interaction_text": "The metabolism of ROSOXACIN can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "donepezil", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Perospirone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "propranolol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with Pregabalin.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "donepezil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "donepezil", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "theophylline", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "zidovudine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "indapamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "benzoic acid", "interaction_type": 47, "interaction_text": "The metabolism of benzoic acid can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Tramadol", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "temazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "theophylline", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "temazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "glyburide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "etizolam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "valsartan", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "famotidine", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "AMPHETAMINE", "interaction_type": 47, "interaction_text": "The metabolism of AMPHETAMINE can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "indapamide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "pergolide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pergolide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "modafinil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "rapamycin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "diltiazem", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "ipratropium", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "flunarizine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "histamine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with histamine.", "severity": 2}
{"drug1": "histamine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with histamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "ketamine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Axitinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "astemizole", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "piperazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "glimepiride", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "nicotine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "meperidine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "alosetron", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "dapsone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "halothane", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "codeine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with codeine.", "severity": 2}
{"drug1": "progesterone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "indinavir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "quetiapine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "loperamide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "isradipine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Quinine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "propofol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "benztropine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "propranolol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "miconazole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "mebendazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "mebendazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "mebendazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "terbinafine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "flutamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "trimipramine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "temazepam", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "tiagabine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "montelukast", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "imipramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "doxazosin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "indomethacin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "zopiclone", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "benztropine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "caffeine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "bupropion", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "methadone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "enalapril", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "epinastine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "epinastine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "formoterol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "epinastine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "buspirone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "spiramycin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Micafungin", "interaction_type": 47, "interaction_text": "The metabolism of Micafungin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "simvastatin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "ethanol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "promazine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with promazine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "mebendazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Netupitant", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "bupropion", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "bupropion", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "teniposide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Apixaban", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "dicumarol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "digitoxin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "digitoxin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "losartan", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "dapsone", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Vemurafenib.", "severity": 2}
{"drug1": "losartan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with losartan.", "severity": 2}
{"drug1": "losartan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "haloprogin", "interaction_type": 47, "interaction_text": "The metabolism of haloprogin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "naratriptan", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with naratriptan.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "ethanol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ethanol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "flunisolide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "flunisolide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Amrinone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Amrinone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "benztropine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "benztropine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "zolpidem", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "dopamine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "clofibrate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "etizolam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "methyprylon", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "trazodone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "trazodone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Permethrin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "flecainide", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "meperidine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "astemizole", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "sibutramine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "clofazimine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Neratinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "epinastine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "leflunomide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "warfarin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "caffeine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "timolol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "propofol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with propofol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "azelastine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "clonidine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "diclofenac", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "azelastine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "donepezil", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "ondansetron", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Macitentan", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "alosetron", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "theophylline", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "betaxolol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "dicumarol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "nilutamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "zolpidem", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "donepezil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "zolpidem", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "warfarin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "codeine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with codeine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "prazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with codeine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "pergolide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "montelukast", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "mebendazole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "felbamate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "promazine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "mianserin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "propofol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "buspirone", "drug2": "Caspofungin", "interaction_type": 47, "interaction_text": "The metabolism of Caspofungin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "tolnaftate", "interaction_type": 47, "interaction_text": "The metabolism of tolnaftate can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "nicotine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "proguanil", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "glipizide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "estazolam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "diazepam", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "tretinoin", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "propranolol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "nicotine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Perampanel", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "propofol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with propofol.", "severity": 2}
{"drug1": "dolasetron", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "formoterol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "isradipine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "etodolac", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "quetiapine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "clonazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "bupropion", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "bupropion", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Tavaborole", "interaction_type": 47, "interaction_text": "The metabolism of Tavaborole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "EFINACONAZOLE", "interaction_type": 47, "interaction_text": "The metabolism of EFINACONAZOLE can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Artemether", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "flutamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "tiagabine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "montelukast", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "toremifene", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with STIRIPENTOL.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "quazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "methadone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with methadone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "nicotine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "selegiline", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "pravastatin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "loratadine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "captopril", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "docetaxel", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "omeprazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "lomustine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "tetracycline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "granisetron", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Torasemide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "cocaine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "valsartan", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "selegiline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "donepezil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "donepezil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "promethazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "estrone", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "glipizide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "etoposide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "teniposide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "teniposide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "levodopa", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "caffeine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "domperidone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "estrone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Encainide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Encainide", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "citalopram", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "guanabenz", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "flurazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "glyburide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "praziquantel", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "estradiol", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "codeine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with codeine.", "severity": 2}
{"drug1": "estradiol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "estradiol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "astemizole", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "dopamine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "valsartan", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "glucosamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "glyburide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "raloxifene", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "diltiazem", "drug2": "cilazapril", "interaction_type": 47, "interaction_text": "The metabolism of cilazapril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Spirapril", "interaction_type": 47, "interaction_text": "The metabolism of Spirapril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "halothane", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "donepezil", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "vincristine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Permethrin", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "theophylline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "theophylline", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "labetalol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "sertraline", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sertraline", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "sertraline", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "tioconazole", "interaction_type": 47, "interaction_text": "The metabolism of tioconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "alosetron", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "estradiol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "digitoxin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "miconazole", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "gliclazide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "valsartan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "aspirin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "clonidine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "timolol", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "halothane", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with halothane.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "lomustine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ketamine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "codeine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "flutamide", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "albendazole", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "selegiline", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "famciclovir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "glyburide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "proguanil", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "azithromycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "proguanil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "dapsone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "etodolac", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "proguanil", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "captopril", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "buspirone", "drug2": "chloroxine", "interaction_type": 47, "interaction_text": "The metabolism of chloroxine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "dapsone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "perphenazine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "cisapride", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "modafinil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "timolol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with timolol.", "severity": 2}
{"drug1": "raloxifene", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "modafinil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "modafinil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "modafinil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "meperidine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "meperidine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Encainide", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "morphine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "sildenafil", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "betaxolol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "spiramycin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Pinaverium.", "severity": 2}
{"drug1": "promazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "epinastine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "prazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with BOPINDOLOL.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "amphotericin b", "interaction_type": 47, "interaction_text": "The metabolism of amphotericin b can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "disulfiram", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "quazepam", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "domperidone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "montelukast", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "montelukast", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "thiotepa", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "imipramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "imipramine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "tinidazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "imipramine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "domperidone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "alosetron", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "nefazodone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "ethanol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "aminophylline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "promazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with promazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "clofazimine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with Bevantolol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Bendamustine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with isoflurane.", "severity": 2}
{"drug1": "lomustine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "digoxin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "testosterone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "theophylline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "warfarin", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "flecainide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "promethazine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "propofol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with propofol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "histamine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "felodipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "ethanol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ethanol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "ethanol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "etizolam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "dopamine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "tolterodine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "halothane", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with halothane.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "astemizole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "warfarin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Letermovir", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "warfarin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "etizolam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "sildenafil", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "thiamylal", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "caffeine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "flunisolide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "terconazole", "interaction_type": 47, "interaction_text": "The metabolism of terconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "miconazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "antipyrine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "miconazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "loperamide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "celecoxib", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "loperamide", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "doxepin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "warfarin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "sertraline", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "etoposide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "lomustine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "lomustine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "felbamate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "loratadine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "epinastine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "famciclovir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "famciclovir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "epinastine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "epinastine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "letrozole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "oxycodone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "quazepam", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "timolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "calcitriol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "pergolide", "drug2": "procarbazine", "interaction_type": 47, "interaction_text": "The metabolism of procarbazine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "amprenavir", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "mebendazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "proguanil", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "granisetron", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "losartan", "drug2": "Miltefosine", "interaction_type": 47, "interaction_text": "The metabolism of Miltefosine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "formoterol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "tretinoin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "dopamine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "citalopram", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "nicotine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "famotidine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "bupropion", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "tetracycline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "loperamide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "omeprazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "meperidine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "metronidazole", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "modafinil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "felodipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "diazepam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "buspirone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "buspirone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "loratadine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "suprofen", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "meperidine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "dolasetron", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "dolasetron", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "Melatonin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "trazodone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Quinine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "domperidone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "enalapril", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "enalapril", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Trovafloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Trovafloxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "losartan", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with losartan.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "dolasetron", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "estrone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "quazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "clonidine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "teniposide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "prazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "epinastine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "testosterone", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "lisinopril", "interaction_type": 47, "interaction_text": "The metabolism of lisinopril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "glyburide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "glyburide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "montelukast", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "donepezil", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "dopamine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "domperidone", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "clofazimine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "bepridil", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "apomorphine", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "glipizide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "modafinil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "caffeine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "etoposide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "caffeine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "carmustine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "donepezil", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "donepezil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Letermovir", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "vincristine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "estrone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with estrone.", "severity": 2}
{"drug1": "doxepin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "morphine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with morphine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "chloroquine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "labetalol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "labetalol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "calcitriol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "morphine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zidovudine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "timolol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with timolol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "maprotiline", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "lomustine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "Macitentan", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "carvedilol", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "dopamine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "dopamine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "tretinoin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "labetalol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with atorvastatin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "mianserin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "bromazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "proguanil", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "felbamate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "proguanil", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "bepridil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "piperazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "piperazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Apremilast", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "etodolac", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "methyprylon", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "dantrolene", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "desipramine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "loratadine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "buspirone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "methyprylon", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "zolpidem", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "doxepin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "nicotine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "argatroban", "interaction_type": 47, "interaction_text": "The metabolism of argatroban can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "raloxifene", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "clonazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "pergolide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "diclofenac", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ramipril", "interaction_type": 47, "interaction_text": "The metabolism of ramipril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Artemether", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "meperidine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "etodolac", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "eperisone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with eperisone.", "severity": 2}
{"drug1": "temazepam", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "amiodarone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Levomilnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Levomilnacipran can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "clozapine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "thiotepa", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "theophylline", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "proguanil", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "granisetron", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "epinastine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "tretinoin", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "mequitazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "busulfan", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "selegiline", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "epinastine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "formoterol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Apixaban", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "dopamine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Telithromycin.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "buspirone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "alprenolol", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "promazine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "bupropion", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "antipyrine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Quinine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "estrone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with estrone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "buspirone", "drug2": "Sertaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Sertaconazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "trimetrexate", "interaction_type": 47, "interaction_text": "The metabolism of trimetrexate can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "dapsone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Anidulafungin", "interaction_type": 47, "interaction_text": "The metabolism of Anidulafungin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Apremilast", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "dapsone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "granisetron", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "antipyrine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "granisetron", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "alprenolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "domperidone", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ajmaline", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "dapsone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "etizolam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "AMPHETAMINE", "interaction_type": 47, "interaction_text": "The metabolism of AMPHETAMINE can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "ambroxol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "labetalol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "triamterene", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "gliclazide", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "bepridil", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "levodopa", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "glyburide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "oxiconazole", "interaction_type": 47, "interaction_text": "The metabolism of oxiconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "naloxone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "naloxone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "naloxone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "progesterone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "propofol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "amphotericin b", "interaction_type": 47, "interaction_text": "The metabolism of amphotericin b can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "timolol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "timolol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with timolol.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "diclofenac", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "alosetron", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "doxepin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "histamine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "theophylline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Pregabalin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "loperamide", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "azelastine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "praziquantel", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "meperidine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "flecainide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "famciclovir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "famciclovir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "doxepin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "theophylline", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "azelastine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "azelastine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "cisapride", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "codeine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "pergolide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "praziquantel", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "praziquantel", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "finasteride", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "maprotiline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "maprotiline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "loperamide", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "finasteride", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "propofol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Axitinib", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "proguanil", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "cisapride", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "zidovudine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "morphine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "mianserin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "loratadine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "glipizide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "propranolol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "epinastine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "captopril", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with captopril.", "severity": 2}
{"drug1": "nifedipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "dapsone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "clonazepam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "nateglinide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "dolasetron", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "dolasetron", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "nateglinide", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "mestranol", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "tretinoin", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "clonazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "clonazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "bupropion", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "losartan", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "caffeine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "prazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "finasteride", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "finasteride", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "flutamide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "Apixaban", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "norgestrel", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "ranitidine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "tiagabine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "clozapine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "pravastatin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "diclofenac", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Dienogest", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "estradiol", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "indinavir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "argatroban", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "cephalexin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "menadione", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with menadione.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "disulfiram", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "bupropion", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "nicotine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "famotidine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "selegiline", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "levodopa", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Bevantolol.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "amoxapine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "flecainide", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "meperidine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "losartan", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "aspirin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "teniposide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "pentamidine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "loratadine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "theophylline", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "estrone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "losartan", "drug2": "amphotericin b", "interaction_type": 47, "interaction_text": "The metabolism of amphotericin b can be decreased when combined with losartan.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ethanol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "mianserin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Perampanel", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Perampanel", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Perampanel", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "testosterone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "trazodone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "moclobemide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "benztropine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "progesterone", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Permethrin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "testosterone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "propofol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "astemizole", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "timolol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with timolol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "loperamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Sitagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Sitagliptin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "letrozole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "mestranol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "warfarin", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "propofol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Artemether", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with penbutolol.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "caffeine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "labetalol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "losartan", "drug2": "bifonazole", "interaction_type": 47, "interaction_text": "The metabolism of bifonazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "estradiol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "loperamide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "quinidine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "codeine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with codeine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "raloxifene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "valsartan", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "etizolam", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "valsartan", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Macitentan", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "flutamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "glipizide", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "glipizide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "finasteride", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "temazepam", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Perospirone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "formoterol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "meprobamate", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "doxepin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "clozapine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "pergolide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "proguanil", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "selegiline", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "theobromine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "selegiline", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "malathion", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with malathion.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "etodolac", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "etodolac", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Udenafil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Axitinib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "loratadine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "felbamate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "mianserin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "proguanil", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "zopiclone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "buspirone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "dopamine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "Ethamolin", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Ethamolin.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "itraconazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "isradipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "halothane", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "digitoxin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "halothane", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "tolterodine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "digoxin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "metronidazole", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "metronidazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "meperidine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "suprofen", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "eperisone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with eperisone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "felbamate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "nateglinide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with gabapentin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "methyprylon", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "betaxolol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "thiotepa", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "tiagabine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "loratadine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "loratadine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "piperazine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "timolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with timolol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ethanol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "zonisamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "teniposide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "teniposide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "proguanil", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "methadone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with methadone.", "severity": 2}
{"drug1": "imipramine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "donepezil", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "nefazodone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "ethanol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "loratadine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "halothane", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "granisetron", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "granisetron", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "docetaxel", "drug2": "chloroxine", "interaction_type": 47, "interaction_text": "The metabolism of chloroxine can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "theophylline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "methadone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with methadone.", "severity": 2}
{"drug1": "aminophylline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "methadone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with methadone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "nicardipine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "menadione", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with menadione.", "severity": 2}
{"drug1": "flunarizine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "triazolam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "bepridil", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "alprenolol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "ajmaline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ajmaline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ajmaline", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "zidovudine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "donepezil", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "mianserin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "trazodone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "testosterone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "losartan", "drug2": "Caspofungin", "interaction_type": 47, "interaction_text": "The metabolism of Caspofungin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "losartan", "drug2": "tolnaftate", "interaction_type": 47, "interaction_text": "The metabolism of tolnaftate can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "labetalol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "malathion", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with malathion.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "clomipramine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "albendazole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "dolasetron", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "nicotine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "theophylline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "theophylline", "drug2": "Gemifloxacin", "interaction_type": 47, "interaction_text": "The metabolism of Gemifloxacin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "busulfan", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with amoxapine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "bepridil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "bepridil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "bepridil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "etodolac", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "sildenafil", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "irbesartan", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "etodolac", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "sotalol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with sotalol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "clofibrate", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "testosterone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "sertraline", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "loperamide", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "glipizide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "celecoxib", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with xylometazoline.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "loperamide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "ipratropium", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "maprotiline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "clonazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "morphine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "lomustine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "modafinil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "temazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "halothane", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with halothane.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "quazepam", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "diltiazem", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "prednisone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "doxepin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "galanthamine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "midazolam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "histamine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "histamine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "temazepam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "methadone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "methadone", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "tazarotene", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "tazarotene", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with tazarotene.", "severity": 2}
{"drug1": "tretinoin", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "lomustine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Axitinib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "glimepiride", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "piperazine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "nicotine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "histamine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "digitoxin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "buspirone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "propranolol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "trazodone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "sertraline", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Tolcapone", "interaction_type": 47, "interaction_text": "The metabolism of Tolcapone can be decreased when combined with diethylstilbestrol.", "severity": 2}
{"drug1": "diazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "cisapride", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "loratadine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "captopril", "interaction_type": 47, "interaction_text": "The metabolism of captopril can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "dolasetron", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "felodipine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "trazodone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Quinine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "Quinine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "trazodone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "trazodone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "granisetron", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "estrone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "quazepam", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "mianserin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "morphine", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Encainide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "glyburide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "hesperetin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "triamterene", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Perospirone", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "clonidine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "caffeine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "miconazole", "interaction_type": 47, "interaction_text": "The metabolism of miconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "sibutramine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bepridil", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "testosterone", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with thiothixene.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Conivaptan.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "theophylline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "aspirin", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "teniposide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "losartan", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "bepridil", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "ajmaline", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "flecainide", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "albendazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "lidocaine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "aspirin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "ketamine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "estrone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with estrone.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "nicardipine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "nicardipine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "ketamine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "losartan", "drug2": "chloroxine", "interaction_type": 47, "interaction_text": "The metabolism of chloroxine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "zidovudine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "dopamine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with metoprolol.", "severity": 2}
{"drug1": "progesterone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "estradiol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "promethazine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "felbamate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "amprenavir", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "pergolide", "drug2": "Toloxatone", "interaction_type": 47, "interaction_text": "The metabolism of Toloxatone can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "testosterone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "propofol", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "proguanil", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "proguanil", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "glyburide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Axitinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Axitinib", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "quinacrine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Ximelagatran", "interaction_type": 47, "interaction_text": "The metabolism of Ximelagatran can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Fosphenytoin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "modafinil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "mestranol", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "pergolide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "mestranol", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "sertraline", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Safinamide", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with tolfenamic acid.", "severity": 2}
{"drug1": "progesterone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "vincristine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "progesterone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "flutamide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "loperamide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Letermovir", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "timolol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with timolol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "domperidone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "ipratropium", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "cabergoline", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "mestranol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "alprazolam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "labetalol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "flutamide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Artemether", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "propranolol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Artemether", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "albendazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "finasteride", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "Quinine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "formoterol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "finasteride", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "finasteride", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "trimipramine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "propofol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "codeine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with codeine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "quazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "epinastine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "selegiline", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "glipizide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "glipizide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "thiotepa", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "thiotepa", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "thiotepa", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "formoterol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Perospirone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "enalapril", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "midazolam", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "enalapril", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "tetracycline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "histamine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "histamine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "nicotine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "famotidine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Encainide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "teniposide", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "estramustine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "histamine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "promazine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "ranitidine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "busulfan", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "busulfan", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "cisapride", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "perphenazine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "metronidazole", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "modafinil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "modafinil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "vinblastine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "morphine", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with morphine.", "severity": 2}
{"drug1": "busulfan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Isoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Isoconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "methyprylon", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "losartan", "drug2": "tioconazole", "interaction_type": 47, "interaction_text": "The metabolism of tioconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "progesterone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "erythromycin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "modafinil", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "selegiline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "naloxone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "azelastine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "glucosamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "progesterone", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "sertraline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "ajmaline", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "timolol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with timolol.", "severity": 2}
{"drug1": "loperamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "ajmaline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "sibutramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "bepridil", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "5-Fluorocytosine", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorocytosine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "leflunomide", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "butenafine", "interaction_type": 47, "interaction_text": "The metabolism of butenafine can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "vincristine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "etizolam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "albendazole", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "loratadine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "astemizole", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "haloperidol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with Arotinolol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "meperidine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "toremifene", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "praziquantel", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "maprotiline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "ondansetron", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "irinotecan", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "betaxolol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "clozapine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "progesterone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "halothane", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "progesterone", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "piperazine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "tolterodine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "nicotine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "propofol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with propofol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "mestranol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "amprenavir", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "flutamide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "zolpidem", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dapsone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dapsone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dapsone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "dopamine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "benztropine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Rifampicin.", "severity": 2}
{"drug1": "progesterone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "propofol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with propofol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "temazepam", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "loperamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Lopinavir.", "severity": 2}
{"drug1": "propranolol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "propranolol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "miconazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "miconazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "loratadine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "finasteride", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "oxiconazole", "interaction_type": 47, "interaction_text": "The metabolism of oxiconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "montelukast", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "loratadine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "ethanol", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "metronidazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "enalapril", "interaction_type": 47, "interaction_text": "The metabolism of enalapril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tiagabine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "tiagabine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "cisapride", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "toremifene", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "cephalexin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "zopiclone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Darunavir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "Darunavir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Darunavir.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "docetaxel", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "lomustine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "modafinil", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "epinastine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "formoterol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "selegiline", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "bupropion", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "domperidone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with oxprenolol.", "severity": 2}
{"drug1": "glyburide", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "lomustine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "vincristine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "losartan", "drug2": "terconazole", "interaction_type": 47, "interaction_text": "The metabolism of terconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "losartan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with losartan.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "trazodone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "resveratrol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "estrone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "etoposide", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "imipramine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Melatonin", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "niclosamide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "digitoxin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "estrone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "methadone", "drug2": "Levomilnacipran", "interaction_type": 47, "interaction_text": "The metabolism of Levomilnacipran can be decreased when combined with methadone.", "severity": 2}
{"drug1": "estrone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "propofol", "drug2": "doxorubicin", "interaction_type": 47, "interaction_text": "The metabolism of doxorubicin can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "ramipril", "interaction_type": 47, "interaction_text": "The metabolism of ramipril can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "theophylline", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "theophylline", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "bepridil", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "dopamine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "ethanol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "trazodone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "trazodone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "moclobemide", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "propofol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "donepezil", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "clofazimine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Neratinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "triamterene", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "warfarin", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "loperamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "losartan", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with losartan.", "severity": 2}
{"drug1": "norgestrel", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "norgestrel", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "losartan", "drug2": "salicylic acid", "interaction_type": 47, "interaction_text": "The metabolism of salicylic acid can be decreased when combined with losartan.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Letermovir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Letermovir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "quazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "toremifene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "bromazepam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "alosetron", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "protriptyline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "alosetron", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "methadone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "diltiazem", "drug2": "fosinopril", "interaction_type": 47, "interaction_text": "The metabolism of fosinopril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "halothane", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Macitentan", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "methyprylon", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "oxazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "ketamine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "methyprylon", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Letermovir", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "propranolol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "midazolam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "montelukast", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "mianserin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "famotidine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "felbamate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "mianserin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "famotidine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "propofol", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with propofol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "propofol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "pergolide", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "amprenavir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "amprenavir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "dopamine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "propranolol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "dapsone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "propranolol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "glipizide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "estazolam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with xylometazoline.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "prazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "loratadine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "isocarboxazid", "interaction_type": 47, "interaction_text": "The metabolism of isocarboxazid can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Palbociclib.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Palbociclib.", "severity": 2}
{"drug1": "lomustine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "formoterol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "loratadine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "nateglinide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "desipramine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "naloxone", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Netupitant", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "naloxone", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "nimodipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with nimodipine.", "severity": 2}
{"drug1": "captopril", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with captopril.", "severity": 2}
{"drug1": "estrone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "citalopram", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "loratadine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Encainide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "estramustine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "estramustine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "piperazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "LEVOFLOXACIN", "interaction_type": 47, "interaction_text": "The metabolism of LEVOFLOXACIN can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "benzoic acid", "interaction_type": 47, "interaction_text": "The metabolism of benzoic acid can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "argatroban", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "nicotine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "argatroban", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "nicotine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "methadone", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "clindamycin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "nicotine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "promazine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with promazine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with BUPRANOLOL.", "severity": 2}
{"drug1": "methadone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with lovastatin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "malathion", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with malathion.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "primidone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with primidone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "busulfan", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "omeprazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "donepezil", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "astemizole", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "estrone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "propranolol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "miconazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "quinidine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "CICLOPIROX", "interaction_type": 47, "interaction_text": "The metabolism of CICLOPIROX can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "progesterone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "felodipine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flecainide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Posaconazole.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with glucosamine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "quinacrine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "guanabenz", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with guanabenz.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "cytarabine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "propofol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with propofol.", "severity": 2}
{"drug1": "flunarizine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "propofol", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with propofol.", "severity": 2}
{"drug1": "progesterone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "estradiol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "benztropine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "calcitriol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "benztropine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "indapamide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "amiodarone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "quetiapine", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "caffeine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "raloxifene", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "raloxifene", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "moclobemide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "halothane", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "propranolol", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "letrozole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "nateglinide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "bromazepam", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "tetracycline", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "theophylline", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "doxazosin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "sertraline", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "lidocaine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Imatinib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "nateglinide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "quinidine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "trandolapril", "interaction_type": 47, "interaction_text": "The metabolism of trandolapril can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Azelnidipine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "histamine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with histamine.", "severity": 2}
{"drug1": "mestranol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "sildenafil", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "suprofen", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "ketamine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Riociguat", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "formoterol", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "formoterol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "clozapine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "amprenavir", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "glyburide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "dapsone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "epinastine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "ketamine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "propranolol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "letrozole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "amiodarone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "cisapride", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "finasteride", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "diazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "alprenolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "formoterol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "cocaine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "morphine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with morphine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "granisetron", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "estrone", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with estrone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "erythromycin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "suprofen", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "finasteride", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with ESMOLOL.", "severity": 2}
{"drug1": "morphine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with morphine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "prazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "felodipine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Encainide", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "trazodone", "interaction_type": 47, "interaction_text": "The metabolism of trazodone can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "ambroxol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "mequitazine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "tinidazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "tinidazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "azelastine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "caffeine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "azelastine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "promazine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with promazine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Caspofungin", "interaction_type": 47, "interaction_text": "The metabolism of Caspofungin can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "tolnaftate", "interaction_type": 47, "interaction_text": "The metabolism of tolnaftate can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "bepridil", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Crizotinib.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "busulfan", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "aminophylline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "caffeine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "zidovudine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "quinidine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "donepezil", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "haloperidol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "donepezil", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "ethanol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "temazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "donepezil", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "losartan", "drug2": "Butoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Butoconazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "sulindac", "drug2": "dimethyl sulfoxide", "interaction_type": 47, "interaction_text": "The metabolism of dimethyl sulfoxide can be decreased when combined with sulindac.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "nicotine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "progesterone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "dopamine", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "histamine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with histamine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ketamine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "propofol", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with propofol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "propofol", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with propofol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "proguanil", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with xylometazoline.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "etizolam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "dopamine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "estradiol", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "benztropine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Axitinib", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "tetracycline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "miconazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "propofol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with propofol.", "severity": 2}
{"drug1": "timolol", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "furazolidone", "interaction_type": 47, "interaction_text": "The metabolism of furazolidone can be decreased when combined with sumatriptan.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "halothane", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "leflunomide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Neratinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "nateglinide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "captopril", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with captopril.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "nateglinide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "quazepam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "doxepin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "loratadine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "estradiol", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with carbamazepine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "modafinil", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "lomustine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "nicotine", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "ondansetron", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "tolterodine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "famciclovir", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with BUPRANOLOL.", "severity": 2}
{"drug1": "epinastine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "epinastine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "duloxetine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with duloxetine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "quazepam", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "midazolam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "glipizide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "glimepiride", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "methadone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "disulfiram", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "ranitidine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "digitoxin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "dapsone", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "flunarizine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "morphine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with morphine.", "severity": 2}
{"drug1": "morphine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "nadolol", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with nadolol.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Tianeptine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "donepezil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "perphenazine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "alprazolam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "domperidone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "ajmaline", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "losartan", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with losartan.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "losartan", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with losartan.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "benztropine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "benztropine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "etoposide", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "etoposide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "enalapril", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "trazodone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "enalapril", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "trazodone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "gliclazide", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "ethanol", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "primidone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with primidone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "oxycodone", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "mestranol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "benztropine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "epinastine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "glyburide", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "glyburide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "norgestrel", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "simvastatin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "loperamide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "loperamide", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "loperamide", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "timolol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "chloroxine", "interaction_type": 47, "interaction_text": "The metabolism of chloroxine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Imidafenacin.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sulfinpyrazone", "interaction_type": 47, "interaction_text": "The metabolism of sulfinpyrazone can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with anagrelide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "vincristine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Macitentan", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Macitentan", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "theophylline", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "clindamycin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "cytarabine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "thiamylal", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Letermovir", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "buspirone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "doxepin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "nilutamide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "digoxin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with propoxyphene.", "severity": 2}
{"drug1": "cilostazol", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "carmustine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with carmustine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "Udenafil", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "cephalexin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "temazepam", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "malathion", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with malathion.", "severity": 2}
{"drug1": "indomethacin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "histamine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with histamine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with atorvastatin.", "severity": 2}
{"drug1": "quinidine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "histamine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "dopamine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "losartan", "drug2": "haloprogin", "interaction_type": 47, "interaction_text": "The metabolism of haloprogin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Tramadol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Perampanel", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Perampanel", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "alosetron", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "estazolam", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "albendazole", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "bupropion", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "disopyramide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "norgestrel", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Atomoxetine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "dopamine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "etizolam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "zolpidem", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "halothane", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "dapsone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "halothane", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with halothane.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "methyprylon", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "diltiazem", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "meperidine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "isradipine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "tretinoin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "desipramine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "felbamate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "loperamide", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with phenobarbital.", "severity": 2}
{"drug1": "loperamide", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "loratadine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "loperamide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "metronidazole", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "metronidazole", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "theobromine", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with theobromine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Artemether", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "nateglinide", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "montelukast", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "finasteride", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "finasteride", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "montelukast", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "montelukast", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "dapsone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "naloxone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with famciclovir.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "dopamine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Sorafenib.", "severity": 2}
{"drug1": "Artemether", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Udenafil", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Artemether", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "selegiline", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with mequitazine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "temazepam", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with digitoxin.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with fluvoxamine.", "severity": 2}
{"drug1": "Quinine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "Quinine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "toremifene", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "estradiol", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "benztropine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "sertraline", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "indinavir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with indinavir.", "severity": 2}
{"drug1": "methadone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "methadone", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "teniposide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "proguanil", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "bupropion", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "felbamate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Encainide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with phenytoin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "histamine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with histamine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "piperazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "perphenazine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "amsacrine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "teniposide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "mefloquine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "aspirin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with terbinafine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Melatonin", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "itraconazole", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with roxithromycin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "oxycodone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "haloperidol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "flecainide", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "methadone", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "estrone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with estrone.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "naloxone", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "ambroxol", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "dopamine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "hexetidine", "interaction_type": 47, "interaction_text": "The metabolism of hexetidine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "donepezil", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with metoclopramide.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Encainide", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "etizolam", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "ethanol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "alclometasone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "morphine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "Asenapine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "triamterene", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "naloxone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "enoxacin", "interaction_type": 47, "interaction_text": "The metabolism of enoxacin can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with propafenone.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "propofol", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "docetaxel", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Encainide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "doxepin", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "progesterone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "progesterone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Melatonin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "warfarin", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "norgestrel", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "protriptyline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "Artemether", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "losartan", "drug2": "rapamycin", "interaction_type": 47, "interaction_text": "The metabolism of rapamycin can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "timolol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "labetalol", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "labetalol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "alosetron", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "doxazosin", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "halothane", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with halothane.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "theophylline", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "theophylline", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "glipizide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Sitagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Sitagliptin can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Delavirdine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "clozapine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "codeine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with codeine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "flutamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "flutamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "sertraline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Elvitegravir.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "malathion", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "midazolam", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "lomustine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "triazolam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "indapamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with indapamide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "clonazepam", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "cisapride", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "Safinamide", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "ropinirole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with zafirlukast.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "nicotine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "morphine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with morphine.", "severity": 2}
{"drug1": "selegiline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "indomethacin", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "loperamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with paroxetine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "nicotine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "loperamide", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ixabepilone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "formoterol", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Pomalidomide.", "severity": 2}
{"drug1": "dapsone", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "diltiazem", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "halothane", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with halothane.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "epinastine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "promazine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with promazine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "cocaine", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nabumetone.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "naloxone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "methyprylon", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "finasteride", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "finasteride", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with finasteride.", "severity": 2}
{"drug1": "trimipramine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Encainide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "meperidine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "astemizole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Dienogest.", "severity": 2}
{"drug1": "estramustine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "tolnaftate", "interaction_type": 47, "interaction_text": "The metabolism of tolnaftate can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "amsacrine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "desipramine", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Perospirone", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "mebendazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Encainide", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Brigatinib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with disopyramide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Netupitant", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "nicotine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "nicotine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "selegiline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "practolol", "drug2": "amodiaquine", "interaction_type": 47, "interaction_text": "The metabolism of amodiaquine can be decreased when combined with practolol.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Quinine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "cephalexin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "sibutramine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Sitagliptin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "disulfiram", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "glipizide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "amprenavir", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "epinastine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "famotidine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "levodopa", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "promazine", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "caffeine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "estrone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with estrone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "docetaxel", "drug2": "tioconazole", "interaction_type": 47, "interaction_text": "The metabolism of tioconazole can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "donepezil", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "olanzapine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with olanzapine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "irbesartan", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "theophylline", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with dacarbazine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "sertraline", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "teniposide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "miconazole", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "dyphylline", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with dyphylline.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Butoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Butoconazole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "riluzole", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with riluzole.", "severity": 2}
{"drug1": "zonisamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with cabergoline.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "domperidone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "domperidone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "loratadine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "methadone", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with methadone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Netupitant", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "etoposide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "felodipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "bepridil", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with bepridil.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "flecainide", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "testosterone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with ESMOLOL.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "nilutamide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "quinacrine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "dapsone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Tofacitinib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "azelastine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with dorzolamide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "quazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "calcitriol", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Perampanel", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "felodipine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "propofol", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "thiamylal", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "benztropine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "warfarin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "sertraline", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "pravastatin", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "ranitidine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "caffeine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "glyburide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "caffeine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "sibutramine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "clofibrate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with clofibrate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with penbutolol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "warfarin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "quazepam", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "warfarin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Safinamide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "methylene blue", "interaction_type": 47, "interaction_text": "The metabolism of methylene blue can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "malathion", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with malathion.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "estradiol", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Sertaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Sertaconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "morphine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with morphine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "trimetrexate", "interaction_type": 47, "interaction_text": "The metabolism of trimetrexate can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "midazolam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "nateglinide", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "sertraline", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "zaleplon", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "pergolide", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "theophylline", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Netupitant", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Netupitant.", "severity": 2}
{"drug1": "Letermovir", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "toremifene", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "ketamine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "codeine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with codeine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with TAMSULOSIN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with cilostazol.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Vildagliptin", "interaction_type": 47, "interaction_text": "The metabolism of Vildagliptin can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with oxycodone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "Perospirone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with salicylic acid.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "montelukast", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "calcitriol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Abemaciclib.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "pergolide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "alosetron", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "cisapride", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with sulfadiazine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with flurbiprofen.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Dabigatran etexilate", "interaction_type": 47, "interaction_text": "The metabolism of Dabigatran etexilate can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Udenafil", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "formoterol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "zolpidem", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "temazepam", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "desipramine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "captopril", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with captopril.", "severity": 2}
{"drug1": "temazepam", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "omeprazole", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "omeprazole", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "buspirone", "drug2": "bifonazole", "interaction_type": 47, "interaction_text": "The metabolism of bifonazole can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "omeprazole", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "letrozole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "letrozole", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "sulconazole", "interaction_type": 47, "interaction_text": "The metabolism of sulconazole can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Apremilast", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "Apremilast", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with sildenafil.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "buspirone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "amsacrine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "halothane", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with halothane.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "proguanil", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with dihydroergotamine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "naloxone", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "digoxin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "metronidazole", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "alprazolam", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "letrozole", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "theophylline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with thiotepa.", "severity": 2}
{"drug1": "donepezil", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "clonidine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "enalapril", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Vilazodone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "pimozide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with pimozide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with Dasatinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Capsaicin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Capsaicin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ticlopidine.", "severity": 2}
{"drug1": "quazepam", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "quazepam", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Aceclofenac.", "severity": 2}
{"drug1": "quazepam", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with PONATINIB.", "severity": 2}
{"drug1": "naloxone", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "domperidone", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Panobinostat.", "severity": 2}
{"drug1": "teniposide", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Levomepromazine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "betaxolol", "interaction_type": 47, "interaction_text": "The metabolism of betaxolol can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "mebendazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "etoposide", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "proguanil", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "tinidazole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "tinidazole", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with tinidazole.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "gliclazide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "caffeine", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "amsacrine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "alosetron", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with allylestrenol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Tramadol.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with orphenadrine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with docetaxel.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with simvastatin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "methadone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with methadone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "caffeine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "ethanol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "diazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "estramustine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "amprenavir", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Mephobarbital.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "donepezil", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "haloperidol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "lidocaine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Isavuconazonium.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Artemether", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "labetalol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "aspirin", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Ibrutinib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "azelastine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "glyburide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "caffeine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with caffeine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with indomethacin.", "severity": 2}
{"drug1": "piperazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with celiprolol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with SUFENTANIL.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "erythromycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "sertraline", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "sertraline", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "captopril", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with captopril.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "astemizole", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "propofol", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "propofol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "dantrolene", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "hydroxychloroquine", "interaction_type": 47, "interaction_text": "The metabolism of hydroxychloroquine can be decreased when combined with Metipranolol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "felbamate", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with felbamate.", "severity": 2}
{"drug1": "astemizole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "desipramine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "timolol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "Permethrin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with oxiconazole.", "severity": 2}
{"drug1": "timolol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with mesoridazine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Dronedarone.", "severity": 2}
{"drug1": "propranolol", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "letrozole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "risperidone", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ALFENTANIL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "diltiazem", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "progesterone", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "antipyrine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "alosetron", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "glipizide", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "doxepin", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "glipizide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with nilvadipine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "testosterone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Olopatadine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Silodosin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Rotigotine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "Artemether", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Yohimbine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "galanthamine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "clozapine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clozapine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "clonidine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "modafinil", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "morphine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with morphine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "clorazepate", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "tretinoin", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "diazepam", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "tiagabine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with prednisone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "THYMOL", "interaction_type": 47, "interaction_text": "The metabolism of THYMOL can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "temazepam", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "Riociguat", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "temazepam", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "histamine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with histamine.", "severity": 2}
{"drug1": "piperazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "albendazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "famotidine", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "bupropion", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "diazepam", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Aliskiren.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "diazepam", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "prazepam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with prazepam.", "severity": 2}
{"drug1": "selegiline", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ketoprofen.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "STIRIPENTOL", "interaction_type": 47, "interaction_text": "The metabolism of STIRIPENTOL can be decreased when combined with CARTEOLOL.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "propranolol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "dapsone", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "dapsone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "dapsone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "mebendazole", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with Riociguat.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "diazepam", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "diazepam", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with diazepam.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "buspirone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with fluvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "ajmaline", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "Encainide", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "domperidone", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "meperidine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "felodipine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with felodipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "cisapride", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Baricitinib.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with SAQUINAVIR.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "ambroxol", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "omeprazole", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with HYDROCODONE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with alfuzosin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Eltrombopag.", "severity": 2}
{"drug1": "levodopa", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "Encainide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Encainide.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "teniposide", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "nicotine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with amodiaquine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "hesperetin", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with hesperetin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with rasagiline.", "severity": 2}
{"drug1": "naloxone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "trazodone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "isradipine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "glyburide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "triamterene", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "triamterene", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with triamterene.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with irinotecan.", "severity": 2}
{"drug1": "loperamide", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with gliclazide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "imipramine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with imipramine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Levonorgestrel.", "severity": 2}
{"drug1": "formoterol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with formoterol.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "dopamine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "dopamine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "flecainide", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with omeprazole.", "severity": 2}
{"drug1": "letrozole", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "nicotine", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "menadione", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with menadione.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "irbesartan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "flutamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Ticagrelor.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Butoconazole", "interaction_type": 47, "interaction_text": "The metabolism of Butoconazole can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "lomustine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with lomustine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "quazepam", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with quazepam.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with RIFABUTIN.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "montelukast", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "donepezil", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "donepezil", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "triazolam", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Tianeptine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with Pioglitazone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "letrozole", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Conivaptan.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Paricalcitol.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "flecainide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "norethindrone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "glipizide", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "glipizide", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "azelastine", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "azelastine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Rosuvastatin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "labetalol", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Vilanterol.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Rimonabant.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with Romidepsin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "pravastatin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "digoxin", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with digoxin.", "severity": 2}
{"drug1": "histamine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with histamine.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "praziquantel", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "testosterone", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "ketamine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Daclatasvir.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with zolmitriptan.", "severity": 2}
{"drug1": "ketamine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with ketamine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with methyltestosterone.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "etodolac", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "Perampanel", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Perampanel.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Tadalafil.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with clomipramine.", "severity": 2}
{"drug1": "estazolam", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Elbasvir.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "clofazimine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with midazolam.", "severity": 2}
{"drug1": "chloroquine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with chloroquine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ergocalciferol.", "severity": 2}
{"drug1": "triazolam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with fluoxetine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Abiraterone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with amprenavir.", "severity": 2}
{"drug1": "mianserin", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with mianserin.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with Fesoterodine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Lorcaserin", "interaction_type": 47, "interaction_text": "The metabolism of Lorcaserin can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "proguanil", "drug2": "topiramate", "interaction_type": 47, "interaction_text": "The metabolism of topiramate can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "proguanil", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "Axitinib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "loratadine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "risperidone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with risperidone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with mefenamic acid.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "domperidone", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with dantrolene.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with moclobemide.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Temsirolimus.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with norgestrel.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with methoxsalen.", "severity": 2}
{"drug1": "tretinoin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "dapsone", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "estazolam", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with estazolam.", "severity": 2}
{"drug1": "Safinamide", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Safinamide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "loratadine", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Lercanidipine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "loratadine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with Ospemifene.", "severity": 2}
{"drug1": "loperamide", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with alprazolam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Aprepitant.", "severity": 2}
{"drug1": "nicotine", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with nitric oxide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "desipramine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "timolol", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "dolasetron", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "dolasetron", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "loperamide", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with amiodarone.", "severity": 2}
{"drug1": "dolasetron", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with oxazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with Eszopiclone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "diclofenac", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "diclofenac", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with diclofenac.", "severity": 2}
{"drug1": "mestranol", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with mestranol.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with OLODATEROL.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Cariprazine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with zopiclone.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "itraconazole", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "manidipine", "drug2": "josamycin", "interaction_type": 47, "interaction_text": "The metabolism of josamycin can be decreased when combined with manidipine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nateglinide.", "severity": 2}
{"drug1": "Artemether", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "Quinine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "captopril", "drug2": "Artemether", "interaction_type": 47, "interaction_text": "The metabolism of Artemether can be decreased when combined with captopril.", "severity": 2}
{"drug1": "etoposide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with etoposide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with Nebivolol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with tiagabine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Repaglinide.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Copanlisib.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "chloroquine", "interaction_type": 47, "interaction_text": "The metabolism of chloroquine can be decreased when combined with AMPHETAMINE.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "montelukast", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "famotidine", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with famotidine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Sitaxsentan.", "severity": 2}
{"drug1": "clindamycin", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "argatroban", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "azithromycin", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with azithromycin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with alprenolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with pergolide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Alogliptin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ropinirole", "interaction_type": 47, "interaction_text": "The metabolism of ropinirole can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "flutamide", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "alclometasone", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Vandetanib.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with CABAZITAXEL.", "severity": 2}
{"drug1": "enalapril", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with enalapril.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with Canagliflozin.", "severity": 2}
{"drug1": "estramustine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with estramustine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with erythromycin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "piperazine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with protriptyline.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "piperazine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Maraviroc.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with IVERMECTIN.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with thalidomide.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "nefazodone", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with nefazodone.", "severity": 2}
{"drug1": "bupropion", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Fingolimod.", "severity": 2}
{"drug1": "buspirone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "argatroban", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with argatroban.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with trimethoprim.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Pirlindole", "interaction_type": 47, "interaction_text": "The metabolism of Pirlindole can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "calcitriol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with calcitriol.", "severity": 2}
{"drug1": "teniposide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Ethamolin", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Ethamolin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "tamoxifen", "interaction_type": 47, "interaction_text": "The metabolism of tamoxifen can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with resveratrol.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Lenvatinib.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Tiotropium.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with buprenorphine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Tapentadol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Teriflunomide", "interaction_type": 47, "interaction_text": "The metabolism of Teriflunomide can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Vardenafil.", "severity": 2}
{"drug1": "busulfan", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with busulfan.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "modafinil", "interaction_type": 47, "interaction_text": "The metabolism of modafinil can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "pargyline", "interaction_type": 47, "interaction_text": "The metabolism of pargyline can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Fosamprenavir.", "severity": 2}
{"drug1": "levodopa", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with levodopa.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Paritaprevir.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "doxepin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with pentobarbital.", "severity": 2}
{"drug1": "norethindrone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "granisetron", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "losartan", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "losartan", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "promazine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with Dronabinol.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "naloxone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Imatinib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "dapsone", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "granisetron", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with granisetron.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "ELIGLUSTAT", "interaction_type": 47, "interaction_text": "The metabolism of ELIGLUSTAT can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with vinblastine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "meprobamate", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with meprobamate.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with cytarabine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "nicotine", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with ibuprofen.", "severity": 2}
{"drug1": "paramethasone", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "proguanil", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with proguanil.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Eletriptan.", "severity": 2}
{"drug1": "benztropine", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with ethanol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "aminophylline", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "etizolam", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with etizolam.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Ciclesonide.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Voriconazole.", "severity": 2}
{"drug1": "rapamycin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with rapamycin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with mirtazapine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Ziprasidone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with ADINAZOLAM.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with disulfiram.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Axitinib.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "progesterone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with nelfinavir.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clotiazepam.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "estradiol", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with pravastatin.", "severity": 2}
{"drug1": "alosetron", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with alosetron.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Risedronic acid.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with clopidogrel.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Rivaroxaban.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with pantoprazole.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with bupivacaine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with sulfisoxazole.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Sunitinib.", "severity": 2}
{"drug1": "leflunomide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with leflunomide.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with quinacrine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "trazodone", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with trazodone.", "severity": 2}
{"drug1": "vincristine", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with vincristine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Fulvestrant.", "severity": 2}
{"drug1": "mefloquine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with IMIQUIMOD.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with tolbutamide.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "sertraline", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with ifosfamide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "estradiol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "teniposide", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "Artemether", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "ajmaline", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "loperamide", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "clofazimine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "trimipramine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "montelukast", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with propranolol.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clozapine", "interaction_type": 47, "interaction_text": "The metabolism of clozapine can be decreased when combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with irbesartan.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with methylphenidate.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "promazine", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with dexlansoprazole.", "severity": 2}
{"drug1": "Macitentan", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Atazanavir.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with Indacaterol.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "Artemether", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Artemether.", "severity": 2}
{"drug1": "thiamylal", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with thiamylal.", "severity": 2}
{"drug1": "zaleplon", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "zaleplon", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with zaleplon.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "lidocaine", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "methadone", "interaction_type": 47, "interaction_text": "The metabolism of methadone can be decreased when combined with RUCAPARIB.", "severity": 2}
{"drug1": "clorazepate", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with Cabozantinib.", "severity": 2}
{"drug1": "glyburide", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Pitavastatin.", "severity": 2}
{"drug1": "glimepiride", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "glimepiride", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with glimepiride.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Fluticasone furoate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with dexamethasone.", "severity": 2}
{"drug1": "nilutamide", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with nilutamide.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with Valbenazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with amitriptyline.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with dicumarol.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "flecainide", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with flecainide.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with oxaliplatin.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with Telaprevir.", "severity": 2}
{"drug1": "azelastine", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with azelastine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with dextroamphetamine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with lansoprazole.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Bedaquiline.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Voxilaprevir.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with amoxicillin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with VALPROIC ACID.", "severity": 2}
{"drug1": "selegiline", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "bupropion", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "pentamidine", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "selegiline", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with chlorzoxazone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Levobupivacaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with clorazepate.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "clarithromycin", "interaction_type": 47, "interaction_text": "The metabolism of clarithromycin can be decreased when combined with podophyllotoxin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Mexiletine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "citalopram", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with pentoxifylline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "montelukast", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "Udenafil", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Udenafil.", "severity": 2}
{"drug1": "estradiol", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with ethosuximide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Crizotinib", "interaction_type": 47, "interaction_text": "The metabolism of Crizotinib can be decreased when combined with clonidine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Halofantrine.", "severity": 2}
{"drug1": "buspirone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Abiraterone", "interaction_type": 47, "interaction_text": "The metabolism of Abiraterone can be decreased when combined with Treprostinil.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with Iloperidone.", "severity": 2}
{"drug1": "Permethrin", "drug2": "clopidogrel", "interaction_type": 47, "interaction_text": "The metabolism of clopidogrel can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "EFINACONAZOLE", "interaction_type": 47, "interaction_text": "The metabolism of EFINACONAZOLE can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Tavaborole", "interaction_type": 47, "interaction_text": "The metabolism of Tavaborole can be decreased when combined with cyclosporin A.", "severity": 2}
{"drug1": "nicotine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ketoconazole.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with TETRABENAZINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with labetalol.", "severity": 2}
{"drug1": "dopamine", "drug2": "losartan", "interaction_type": 47, "interaction_text": "The metabolism of losartan can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with raloxifene.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Vemurafenib.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Asunaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Asunaprevir can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with ropinirole.", "severity": 2}
{"drug1": "progesterone", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "isradipine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with isradipine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "rosiglitazone", "interaction_type": 47, "interaction_text": "The metabolism of rosiglitazone can be decreased when combined with Enzalutamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with nortriptyline.", "severity": 2}
{"drug1": "niclosamide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "niclosamide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with niclosamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "ranitidine", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with ranitidine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with perphenazine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Nilotinib", "interaction_type": 47, "interaction_text": "The metabolism of Nilotinib can be decreased when combined with Estrone sulfate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "propofol", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with propofol.", "severity": 2}
{"drug1": "timolol", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with timolol.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "nicotine", "interaction_type": 47, "interaction_text": "The metabolism of nicotine can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Sorafenib", "interaction_type": 47, "interaction_text": "The metabolism of Sorafenib can be decreased when combined with metronidazole.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "manidipine", "interaction_type": 47, "interaction_text": "The metabolism of manidipine can be decreased when combined with rosiglitazone.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "theophylline", "interaction_type": 47, "interaction_text": "The metabolism of theophylline can be decreased when combined with Ulipristal.", "severity": 2}
{"drug1": "glyburide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with glyburide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "modafinil", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with modafinil.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with zolpidem.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Clevidipine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Permethrin.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with Rolapitant.", "severity": 2}
{"drug1": "dapsone", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dopamine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with bromazepam.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Apremilast.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Ropivacaine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "naloxone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "epinastine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "thiotepa", "interaction_type": 47, "interaction_text": "The metabolism of thiotepa can be decreased when combined with Ketobemidone.", "severity": 2}
{"drug1": "epinastine", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with flurazepam.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with zalcitabine.", "severity": 2}
{"drug1": "meperidine", "drug2": "celecoxib", "interaction_type": 47, "interaction_text": "The metabolism of celecoxib can be decreased when combined with meperidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with venlafaxine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with itraconazole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "losartan", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with Ruxolitinib.", "severity": 2}
{"drug1": "naloxone", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with naloxone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with tolterodine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with NAPROXEN.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with GUANFACINE.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with Midostaurin.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Velpatasvir.", "severity": 2}
{"drug1": "trimipramine", "drug2": "metoprolol", "interaction_type": 47, "interaction_text": "The metabolism of metoprolol can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with chlorpropamide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with SERTINDOLE.", "severity": 2}
{"drug1": "cocaine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with cocaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "miconazole", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with flunitrazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "desipramine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with efavirenz.", "severity": 2}
{"drug1": "miconazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with miconazole.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with celecoxib.", "severity": 2}
{"drug1": "montelukast", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with montelukast.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with tacrolimus.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with bezafibrate.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with zonisamide.", "severity": 2}
{"drug1": "loratadine", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with mebendazole.", "severity": 2}
{"drug1": "antipyrine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with antipyrine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Vitamin D3.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with Lumefantrine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "CAPECITABINE", "interaction_type": 47, "interaction_text": "The metabolism of CAPECITABINE can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with IDARUBICIN.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with clindamycin.", "severity": 2}
{"drug1": "loperamide", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with loperamide.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with ambroxol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with tretinoin.", "severity": 2}
{"drug1": "nicotine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with thioridazine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Regorafenib.", "severity": 2}
{"drug1": "methadone", "drug2": "omeprazole", "interaction_type": 47, "interaction_text": "The metabolism of omeprazole can be decreased when combined with methadone.", "severity": 2}
{"drug1": "promethazine", "drug2": "Mirabegron", "interaction_type": 47, "interaction_text": "The metabolism of Mirabegron can be decreased when combined with promethazine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "paroxetine", "interaction_type": 47, "interaction_text": "The metabolism of paroxetine can be decreased when combined with Cevimeline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Olaparib", "interaction_type": 47, "interaction_text": "The metabolism of Olaparib can be decreased when combined with chlordiazepoxide.", "severity": 2}
{"drug1": "clofazimine", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with clofazimine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with nitrendipine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with tamoxifen.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with SERATRODAST.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with LISURIDE.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with cephalexin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with nisoldipine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with epoprostenol.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with rabeprazole.", "severity": 2}
{"drug1": "Quinine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Quinine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Levocetirizine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with Ethylmorphine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "progesterone", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with progesterone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "epinastine", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with epinastine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Alogliptin", "interaction_type": 47, "interaction_text": "The metabolism of Alogliptin can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with atenolol.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "promazine", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with promazine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Tenofovir disoproxil", "interaction_type": 47, "interaction_text": "The metabolism of Tenofovir disoproxil can be decreased when combined with bupropion.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Asenapine.", "severity": 2}
{"drug1": "methadone", "drug2": "Escitalopram", "interaction_type": 47, "interaction_text": "The metabolism of Escitalopram can be decreased when combined with methadone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with galanthamine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with trimipramine.", "severity": 2}
{"drug1": "domperidone", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with mefloquine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with nitrazepam.", "severity": 2}
{"drug1": "domperidone", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with clarithromycin.", "severity": 2}
{"drug1": "loratadine", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with loratadine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with Grazoprevir.", "severity": 2}
{"drug1": "buspirone", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with buspirone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with Ambrisentan.", "severity": 2}
{"drug1": "amsacrine", "drug2": "ritonavir", "interaction_type": 47, "interaction_text": "The metabolism of ritonavir can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with amsacrine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with carisoprodol.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Enasidenib.", "severity": 2}
{"drug1": "theophylline", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "losartan", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "suprofen", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with suprofen.", "severity": 2}
{"drug1": "theophylline", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with theophylline.", "severity": 2}
{"drug1": "promazine", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with promazine.", "severity": 2}
{"drug1": "losartan", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "losartan", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with losartan.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with Frovatriptan.", "severity": 2}
{"drug1": "aminophylline", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "flunarizine", "drug2": "clomipramine", "interaction_type": 47, "interaction_text": "The metabolism of clomipramine can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "gemfibrozil", "interaction_type": 47, "interaction_text": "The metabolism of gemfibrozil can be decreased when combined with flunarizine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "aspirin", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with aspirin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with pilocarpine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Idelalisib", "interaction_type": 47, "interaction_text": "The metabolism of Idelalisib can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Cobicistat", "interaction_type": 47, "interaction_text": "The metabolism of Cobicistat can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "Melatonin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with lomefloxacin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Melatonin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Etoricoxib.", "severity": 2}
{"drug1": "promazine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with promazine.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with APRINDINE.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with gemfibrozil.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with praziquantel.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with Gefitinib.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with Cinacalcet.", "severity": 2}
{"drug1": "domperidone", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with domperidone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with bromocriptine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with Esomeprazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with doxorubicin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Esomeprazole", "interaction_type": 47, "interaction_text": "The metabolism of Esomeprazole can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "tolperisone", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with tolperisone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "lidocaine", "interaction_type": 47, "interaction_text": "The metabolism of lidocaine can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with ajmaline.", "severity": 2}
{"drug1": "quinidine", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with quinidine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Lapatinib", "interaction_type": 47, "interaction_text": "The metabolism of Lapatinib can be decreased when combined with Apixaban.", "severity": 2}
{"drug1": "haloperidol", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with haloperidol.", "severity": 2}
{"drug1": "citalopram", "drug2": "cocaine", "interaction_type": 47, "interaction_text": "The metabolism of cocaine can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "albendazole", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Crisaborole", "interaction_type": 47, "interaction_text": "The metabolism of Crisaborole can be decreased when combined with hydromorphone.", "severity": 2}
{"drug1": "albendazole", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with albendazole.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with methylprednisolone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "desipramine", "interaction_type": 47, "interaction_text": "The metabolism of desipramine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Escitalopram.", "severity": 2}
{"drug1": "lidocaine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with lidocaine.", "severity": 2}
{"drug1": "testosterone", "drug2": "felodipine", "interaction_type": 47, "interaction_text": "The metabolism of felodipine can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with Dasabuvir.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with cisapride.", "severity": 2}
{"drug1": "testosterone", "drug2": "irbesartan", "interaction_type": 47, "interaction_text": "The metabolism of irbesartan can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Brivaracetam.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with methoxyflurane.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "sertraline", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Lumiracoxib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with Bortezomib.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with BISOPROLOL.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "tranylcypromine", "interaction_type": 47, "interaction_text": "The metabolism of tranylcypromine can be decreased when combined with chloramphenicol.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with cyclophosphamide.", "severity": 2}
{"drug1": "benztropine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with benztropine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with Almotriptan.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with phenoxybenzamine.", "severity": 2}
{"drug1": "dapsone", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with dapsone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with nevirapine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with dextromethorphan.", "severity": 2}
{"drug1": "citalopram", "drug2": "Fosamprenavir", "interaction_type": 47, "interaction_text": "The metabolism of Fosamprenavir can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "alclometasone", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with alclometasone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Armodafinil", "interaction_type": 47, "interaction_text": "The metabolism of Armodafinil can be decreased when combined with Pipotiazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with sertraline.", "severity": 2}
{"drug1": "nicardipine", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with nicardipine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Pioglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Pioglitazone can be decreased when combined with acetaminophen.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with flunisolide.", "severity": 2}
{"drug1": "piperazine", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with piperazine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with teniposide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with testosterone.", "severity": 2}
{"drug1": "triazolam", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with Erlotinib.", "severity": 2}
{"drug1": "triazolam", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with triazolam.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Telithromycin", "interaction_type": 47, "interaction_text": "The metabolism of Telithromycin can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with bicalutamide.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Lumefantrine", "interaction_type": 47, "interaction_text": "The metabolism of Lumefantrine can be decreased when combined with Nitrofural.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with chlorpheniramine.", "severity": 2}
{"drug1": "promazine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with promazine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Neratinib.", "severity": 2}
{"drug1": "valsartan", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with Rupatadine.", "severity": 2}
{"drug1": "dopamine", "drug2": "fluoxetine", "interaction_type": 47, "interaction_text": "The metabolism of fluoxetine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lopinavir", "interaction_type": 47, "interaction_text": "The metabolism of Lopinavir can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with PERHEXILINE.", "severity": 2}
{"drug1": "dopamine", "drug2": "duloxetine", "interaction_type": 47, "interaction_text": "The metabolism of duloxetine can be decreased when combined with dopamine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Trabectedin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Isavuconazonium", "interaction_type": 47, "interaction_text": "The metabolism of Isavuconazonium can be decreased when combined with spiramycin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "ketoconazole", "interaction_type": 47, "interaction_text": "The metabolism of ketoconazole can be decreased when combined with KETAZOLAM.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with tetracycline.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "Macitentan", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Macitentan.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Telaprevir", "interaction_type": 47, "interaction_text": "The metabolism of Telaprevir can be decreased when combined with aminophylline.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Nilotinib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "haloperidol", "interaction_type": 47, "interaction_text": "The metabolism of haloperidol can be decreased when combined with quetiapine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with astemizole.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with ZILEUTON.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "bupropion", "interaction_type": 47, "interaction_text": "The metabolism of bupropion can be decreased when combined with Pazopanib.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "sulfadiazine", "interaction_type": 47, "interaction_text": "The metabolism of sulfadiazine can be decreased when combined with Dapagliflozin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "propofol", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with VORTIOXETINE.", "severity": 2}
{"drug1": "letrozole", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with letrozole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with Lapatinib.", "severity": 2}
{"drug1": "propofol", "drug2": "pyrimethamine", "interaction_type": 47, "interaction_text": "The metabolism of pyrimethamine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with propofol.", "severity": 2}
{"drug1": "propofol", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with propofol.", "severity": 2}
{"drug1": "sibutramine", "drug2": "sulfisoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfisoxazole can be decreased when combined with sibutramine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with sulfinpyrazone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with acetylcholine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Rolapitant", "interaction_type": 47, "interaction_text": "The metabolism of Rolapitant can be decreased when combined with ondansetron.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with benzphetamine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with oxybutynin.", "severity": 2}
{"drug1": "donepezil", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with donepezil.", "severity": 2}
{"drug1": "warfarin", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with warfarin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "imipramine", "interaction_type": 47, "interaction_text": "The metabolism of imipramine can be decreased when combined with Debrisoquine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nelfinavir", "interaction_type": 47, "interaction_text": "The metabolism of nelfinavir can be decreased when combined with sevoflurane.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with trifluoperazine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with zaltoprofen.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with Gliquidone.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Vitamin D3", "interaction_type": 47, "interaction_text": "The metabolism of Vitamin D3 can be decreased when combined with Vismodegib.", "severity": 2}
{"drug1": "ipratropium", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "ipratropium", "drug2": "doxycycline", "interaction_type": 47, "interaction_text": "The metabolism of doxycycline can be decreased when combined with ipratropium.", "severity": 2}
{"drug1": "halothane", "drug2": "valsartan", "interaction_type": 47, "interaction_text": "The metabolism of valsartan can be decreased when combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with halothane.", "severity": 2}
{"drug1": "apomorphine", "drug2": "AMPHETAMINE", "interaction_type": 47, "interaction_text": "The metabolism of AMPHETAMINE can be decreased when combined with apomorphine.", "severity": 2}
{"drug1": "etodolac", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with etodolac.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with clonazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with oxymorphone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with oxaprozin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with hydrocortisone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Voriconazole", "interaction_type": 47, "interaction_text": "The metabolism of Voriconazole can be decreased when combined with norethindrone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "moclobemide", "interaction_type": 47, "interaction_text": "The metabolism of moclobemide can be decreased when combined with diltiazem.", "severity": 2}
{"drug1": "Torasemide", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Torasemide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Quinine", "interaction_type": 47, "interaction_text": "The metabolism of Quinine can be decreased when combined with Zuclopenthixol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with benzyl alcohol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "VALPROIC ACID", "interaction_type": 47, "interaction_text": "The metabolism of VALPROIC ACID can be decreased when combined with Lornoxicam.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Boceprevir", "interaction_type": 47, "interaction_text": "The metabolism of Boceprevir can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with pentamidine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "erythromycin", "interaction_type": 47, "interaction_text": "The metabolism of erythromycin can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "fluvoxamine", "interaction_type": 47, "interaction_text": "The metabolism of fluvoxamine can be decreased when combined with vinorelbine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "fluconazole", "interaction_type": 47, "interaction_text": "The metabolism of fluconazole can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with diphenhydramine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "floxuridine", "interaction_type": 47, "interaction_text": "The metabolism of floxuridine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with Prasugrel.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with cinnarizine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with ethinyl estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "trimethoprim", "interaction_type": 47, "interaction_text": "The metabolism of trimethoprim can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "chloramphenicol", "interaction_type": 47, "interaction_text": "The metabolism of chloramphenicol can be decreased when combined with estradiol.", "severity": 2}
{"drug1": "temazepam", "drug2": "SAQUINAVIR", "interaction_type": 47, "interaction_text": "The metabolism of SAQUINAVIR can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "leflunomide", "interaction_type": 47, "interaction_text": "The metabolism of leflunomide can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "fluvastatin", "interaction_type": 47, "interaction_text": "The metabolism of fluvastatin can be decreased when combined with LESINURAD.", "severity": 2}
{"drug1": "temazepam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with triamcinolone.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with Letermovir.", "severity": 2}
{"drug1": "valsartan", "drug2": "indinavir", "interaction_type": 47, "interaction_text": "The metabolism of indinavir can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "valsartan", "drug2": "lovastatin", "interaction_type": 47, "interaction_text": "The metabolism of lovastatin can be decreased when combined with valsartan.", "severity": 2}
{"drug1": "temazepam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with temazepam.", "severity": 2}
{"drug1": "nicotine", "drug2": "tolbutamide", "interaction_type": 47, "interaction_text": "The metabolism of tolbutamide can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Mexiletine", "interaction_type": 47, "interaction_text": "The metabolism of Mexiletine can be decreased when combined with clenbuterol.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with fenofibrate.", "severity": 2}
{"drug1": "doxepin", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with doxepin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with Vernakalant.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "nevirapine", "interaction_type": 47, "interaction_text": "The metabolism of nevirapine can be decreased when combined with Pimecrolimus.", "severity": 2}
{"drug1": "nicotine", "drug2": "diltiazem", "interaction_type": 47, "interaction_text": "The metabolism of diltiazem can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "flutamide", "drug2": "cyclosporin A", "interaction_type": 47, "interaction_text": "The metabolism of cyclosporin A can be decreased when combined with flutamide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "amiodarone", "interaction_type": 47, "interaction_text": "The metabolism of amiodarone can be decreased when combined with TASOSARTAN.", "severity": 2}
{"drug1": "ritonavir", "drug2": "cimetidine", "interaction_type": 47, "interaction_text": "The metabolism of cimetidine can be decreased when combined with ritonavir.", "severity": 2}
{"drug1": "methyprylon", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with methyprylon.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "VERAPAMIL", "interaction_type": 47, "interaction_text": "The metabolism of VERAPAMIL can be decreased when combined with Retapamulin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "caffeine", "interaction_type": 47, "interaction_text": "The metabolism of caffeine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "selegiline", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "sildenafil", "interaction_type": 47, "interaction_text": "The metabolism of sildenafil can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "thioridazine", "interaction_type": 47, "interaction_text": "The metabolism of thioridazine can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "azithromycin", "interaction_type": 47, "interaction_text": "The metabolism of azithromycin can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "ticlopidine", "interaction_type": 47, "interaction_text": "The metabolism of ticlopidine can be decreased when combined with daunorubicin.", "severity": 2}
{"drug1": "glipizide", "drug2": "nicardipine", "interaction_type": 47, "interaction_text": "The metabolism of nicardipine can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "glipizide", "drug2": "efavirenz", "interaction_type": 47, "interaction_text": "The metabolism of efavirenz can be decreased when combined with glipizide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with Bexarotene.", "severity": 2}
{"drug1": "selegiline", "drug2": "5-Fluorouracil", "interaction_type": 47, "interaction_text": "The metabolism of 5-Fluorouracil can be decreased when combined with selegiline.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "isradipine", "interaction_type": 47, "interaction_text": "The metabolism of isradipine can be decreased when combined with EXEMESTANE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Zucapsaicin", "interaction_type": 47, "interaction_text": "The metabolism of Zucapsaicin can be decreased when combined with maprotiline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Bortezomib", "interaction_type": 47, "interaction_text": "The metabolism of Bortezomib can be decreased when combined with Hexobarbital.", "severity": 2}
{"drug1": "Perospirone", "drug2": "terbinafine", "interaction_type": 47, "interaction_text": "The metabolism of terbinafine can be decreased when combined with Perospirone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Eslicarbazepine acetate", "interaction_type": 47, "interaction_text": "The metabolism of Eslicarbazepine acetate can be decreased when combined with Levomilnacipran.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dutasteride.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "clotrimazole", "interaction_type": 47, "interaction_text": "The metabolism of clotrimazole can be decreased when combined with rizatriptan.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Ticagrelor", "interaction_type": 47, "interaction_text": "The metabolism of Ticagrelor can be decreased when combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "dihydroergotamine", "interaction_type": 47, "interaction_text": "The metabolism of dihydroergotamine can be decreased when combined with L-thyroxine.", "severity": 2}
{"drug1": "citalopram", "drug2": "quinidine", "interaction_type": 47, "interaction_text": "The metabolism of quinidine can be decreased when combined with citalopram.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "itraconazole", "interaction_type": 47, "interaction_text": "The metabolism of itraconazole can be decreased when combined with Lorcaserin.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with dolasetron.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "diphenhydramine", "interaction_type": 47, "interaction_text": "The metabolism of diphenhydramine can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Atazanavir", "interaction_type": 47, "interaction_text": "The metabolism of Atazanavir can be decreased when combined with prochlorperazine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with nifedipine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Midostaurin", "interaction_type": 47, "interaction_text": "The metabolism of Midostaurin can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "doxazosin", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with doxazosin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "sulfamethoxazole", "interaction_type": 47, "interaction_text": "The metabolism of sulfamethoxazole can be decreased when combined with Ximelagatran.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "SIMEPREVIR", "interaction_type": 47, "interaction_text": "The metabolism of SIMEPREVIR can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "pantoprazole", "interaction_type": 47, "interaction_text": "The metabolism of pantoprazole can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with zidovudine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Cinacalcet", "interaction_type": 47, "interaction_text": "The metabolism of Cinacalcet can be decreased when combined with Dexfenfluramine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "RUCAPARIB", "interaction_type": 47, "interaction_text": "The metabolism of RUCAPARIB can be decreased when combined with paramethasone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Atomoxetine", "interaction_type": 47, "interaction_text": "The metabolism of Atomoxetine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "clemastine", "interaction_type": 47, "interaction_text": "The metabolism of clemastine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "venlafaxine", "interaction_type": 47, "interaction_text": "The metabolism of venlafaxine can be decreased when combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "toremifene", "drug2": "Dothiepin", "interaction_type": 47, "interaction_text": "The metabolism of Dothiepin can be decreased when combined with toremifene.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Levomepromazine", "interaction_type": 47, "interaction_text": "The metabolism of Levomepromazine can be decreased when combined with nicergoline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "citalopram", "interaction_type": 47, "interaction_text": "The metabolism of citalopram can be decreased when combined with carvedilol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "PRIMAQUINE", "interaction_type": 47, "interaction_text": "The metabolism of PRIMAQUINE can be decreased when combined with betaxolol.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Lobeglitazone", "interaction_type": 47, "interaction_text": "The metabolism of Lobeglitazone can be decreased when combined with pyrazinamide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "isoniazid", "interaction_type": 47, "interaction_text": "The metabolism of isoniazid can be decreased when combined with Mirabegron.", "severity": 2}
{"drug1": "nicotine", "drug2": "rabeprazole", "interaction_type": 47, "interaction_text": "The metabolism of rabeprazole can be decreased when combined with nicotine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Dronedarone", "interaction_type": 47, "interaction_text": "The metabolism of Dronedarone can be decreased when combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Reboxetine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Imatinib", "interaction_type": 47, "interaction_text": "The metabolism of Imatinib can be decreased when combined with Ramelteon.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with Venetoclax.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "sertraline", "interaction_type": 47, "interaction_text": "The metabolism of sertraline can be decreased when combined with Deutetrabenazine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "zafirlukast", "interaction_type": 47, "interaction_text": "The metabolism of zafirlukast can be decreased when combined with tenoxicam.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "nefazodone", "interaction_type": 47, "interaction_text": "The metabolism of nefazodone can be decreased when combined with Palonosetron.", "severity": 2}
{"drug1": "desipramine", "drug2": "Delavirdine", "interaction_type": 47, "interaction_text": "The metabolism of Delavirdine can be decreased when combined with desipramine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Topiroxostat", "interaction_type": 47, "interaction_text": "The metabolism of Topiroxostat can be decreased when combined with Arformoterol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "promazine", "interaction_type": 47, "interaction_text": "The metabolism of promazine can be decreased when combined with Remoxipride.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "RANOLAZINE", "interaction_type": 47, "interaction_text": "The metabolism of RANOLAZINE can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ziprasidone", "interaction_type": 47, "interaction_text": "The metabolism of Ziprasidone can be decreased when combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Darunavir", "interaction_type": 47, "interaction_text": "The metabolism of Darunavir can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Posaconazole", "interaction_type": 47, "interaction_text": "The metabolism of Posaconazole can be decreased when combined with Salmeterol.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "atorvastatin may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "colchicine", "drug2": "fenofibrate", "interaction_type": 48, "interaction_text": "colchicine may increase the myopathic rhabdomyolysis activities of fenofibrate.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "Coenzyme Q10 may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "colchicine", "interaction_type": 48, "interaction_text": "Coenzyme Q10 may increase the myopathic rhabdomyolysis activities of colchicine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "pravastatin may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Rosuvastatin", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of Rosuvastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "colchicine", "interaction_type": 48, "interaction_text": "pravastatin may increase the myopathic rhabdomyolysis activities of colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "clofibrate", "interaction_type": 48, "interaction_text": "colchicine may increase the myopathic rhabdomyolysis activities of clofibrate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "pravastatin may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "fluvastatin", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of fluvastatin.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "gemfibrozil may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Etofibrate", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "Etofibrate may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "fluvastatin may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "fluvastatin may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Fenofibric acid", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "Fenofibric acid may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "atorvastatin may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "atorvastatin may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "colchicine", "drug2": "Etofibrate", "interaction_type": 48, "interaction_text": "colchicine may increase the myopathic rhabdomyolysis activities of Etofibrate.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "pravastatin", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of pravastatin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "atorvastatin", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of atorvastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "Pitavastatin may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "simvastatin", "drug2": "azithromycin", "interaction_type": 48, "interaction_text": "simvastatin may increase the myopathic rhabdomyolysis activities of azithromycin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "simvastatin may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "lovastatin", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of lovastatin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "clofibrate may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "colchicine", "drug2": "Fenofibric acid", "interaction_type": 48, "interaction_text": "colchicine may increase the myopathic rhabdomyolysis activities of Fenofibric acid.", "severity": 2}
{"drug1": "simvastatin", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "simvastatin may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "lovastatin may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "bezafibrate may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "colchicine", "interaction_type": 48, "interaction_text": "Rosuvastatin may increase the myopathic rhabdomyolysis activities of colchicine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "lovastatin may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "clofibrate", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "clofibrate may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "colchicine", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "colchicine may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "Rosuvastatin may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "Coenzyme Q10 may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "pravastatin may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "lovastatin", "drug2": "azithromycin", "interaction_type": 48, "interaction_text": "lovastatin may increase the myopathic rhabdomyolysis activities of azithromycin.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "bezafibrate may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "gemfibrozil may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "colchicine", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "colchicine may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "fenofibrate may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "Etofibrate", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "Etofibrate may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "Pitavastatin may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "Rosuvastatin may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "lovastatin", "drug2": "RANOLAZINE", "interaction_type": 48, "interaction_text": "lovastatin may increase the myopathic rhabdomyolysis activities of RANOLAZINE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "simvastatin may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "Coenzyme Q10 may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "Pitavastatin may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "fenofibrate may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Coenzyme Q10", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of Coenzyme Q10.", "severity": 2}
{"drug1": "lovastatin", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "lovastatin may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "simvastatin", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of simvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "fluvastatin may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ACIPIMOX", "interaction_type": 48, "interaction_text": "Rosuvastatin may increase the myopathic rhabdomyolysis activities of ACIPIMOX.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "Rosuvastatin may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "colchicine", "interaction_type": 48, "interaction_text": "fluvastatin may increase the myopathic rhabdomyolysis activities of colchicine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "atorvastatin may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "colchicine", "interaction_type": 48, "interaction_text": "atorvastatin may increase the myopathic rhabdomyolysis activities of colchicine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "fluvastatin may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "simvastatin", "drug2": "colchicine", "interaction_type": 48, "interaction_text": "simvastatin may increase the myopathic rhabdomyolysis activities of colchicine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "simvastatin may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "lovastatin", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "lovastatin may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Pitavastatin", "interaction_type": 48, "interaction_text": "Trabectedin may increase the myopathic rhabdomyolysis activities of Pitavastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "azithromycin", "interaction_type": 48, "interaction_text": "atorvastatin may increase the myopathic rhabdomyolysis activities of azithromycin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "zidovudine may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "colchicine", "interaction_type": 48, "interaction_text": "Pitavastatin may increase the myopathic rhabdomyolysis activities of colchicine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "bezafibrate", "interaction_type": 48, "interaction_text": "Pitavastatin may increase the myopathic rhabdomyolysis activities of bezafibrate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "gemfibrozil", "interaction_type": 48, "interaction_text": "pravastatin may increase the myopathic rhabdomyolysis activities of gemfibrozil.", "severity": 2}
{"drug1": "Fenofibric acid", "drug2": "Raltegravir", "interaction_type": 48, "interaction_text": "Fenofibric acid may increase the myopathic rhabdomyolysis activities of Raltegravir.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with dobutamine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with procaine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Mephobarbital.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with gabapentin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with hydrocortisone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with brotizolam.", "severity": 2}
{"drug1": "vindesine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vindesine is combined with clozapine.", "severity": 2}
{"drug1": "ibudilast", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with salicylic acid.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with fexofenadine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with potassium ion.", "severity": 2}
{"drug1": "nefazodone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with triflupromazine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Etomidate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with glutethimide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with sulpiride.", "severity": 2}
{"drug1": "Tramadol", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with bupivacaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Ropivacaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with morphine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with carisoprodol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with nimesulide.", "severity": 2}
{"drug1": "cerulenin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with diltiazem.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with isradipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with clomipramine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with fluoxetine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with isocarboxazid.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Tolvaptan.", "severity": 2}
{"drug1": "quazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with METAXALONE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with budesonide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Retigabine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "reserpine", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with carbamazepine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Phenelzine.", "severity": 2}
{"drug1": "atenolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "floxuridine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floxuridine is combined with clozapine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with desipramine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Ketobemidone.", "severity": 2}
{"drug1": "Trospium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with nalbuphine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with lomustine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Asenapine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with epirizole.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with mitoxantrone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Iloperidone.", "severity": 2}
{"drug1": "methimazole", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methimazole is combined with clozapine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Eprosartan.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with ZILEUTON.", "severity": 2}
{"drug1": "clemastine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nabumetone", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with hydrocortisone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Lurasidone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with etodolac.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Halazepam.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with physostigmine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Risedronic acid.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with proparacaine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with sevoflurane.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with Levocetirizine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with metolazone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with promethazine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with CARTEOLOL.", "severity": 2}
{"drug1": "methadone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with mepivacaine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "methadone", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with zaleplon.", "severity": 2}
{"drug1": "selegiline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with clenbuterol.", "severity": 2}
{"drug1": "methadone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Desloratadine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with quinapril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with chlorothiazide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "terbutaline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with clenbuterol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with bumetanide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with dantrolene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with scopolamine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Iloperidone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with furosemide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with tizanidine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with nadolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with propranolol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "meperidine", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Drospirenone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Pomalidomide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with isocarboxazid.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with triprolidine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with desipramine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with terazosin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with methylphenidate.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with methocarbamol.", "severity": 2}
{"drug1": "diazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Isoflurophate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with galanthamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "midodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with midodrine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with DEZOCINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with ethotoin.", "severity": 2}
{"drug1": "thalidomide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "diazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Difenoxin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with dibucaine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Pizotifen.", "severity": 2}
{"drug1": "thiopental", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with tranylcypromine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with diltiazem.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with protriptyline.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with procarbazine.", "severity": 2}
{"drug1": "atenolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with acetylcholine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Lornoxicam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Milnacipran.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Melatonin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with betamethasone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with thioridazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with dantrolene.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with propofol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Levobupivacaine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Escitalopram.", "severity": 2}
{"drug1": "lorazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "clonazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with sertraline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with chlormezanone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with isradipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with venlafaxine.", "severity": 2}
{"drug1": "thiopental", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with clemastine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with thiamylal.", "severity": 2}
{"drug1": "duloxetine", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with droperidol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with desipramine.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with ropinirole.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Flibanserin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with metoprolol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with halothane.", "severity": 2}
{"drug1": "cabergoline", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with dextromethorphan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with maprotiline.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with quetiapine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with isoxsuprine.", "severity": 2}
{"drug1": "morphine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nitrazepam.", "severity": 2}
{"drug1": "leflunomide", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with epirizole.", "severity": 2}
{"drug1": "morphine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Difenoxin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with indomethacin.", "severity": 2}
{"drug1": "butamben", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with carisoprodol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with dyclonine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Oxetacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with propoxyphene.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "colchicine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with colchicine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Etidocaine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "suprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with difluprednate.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with procarbazine.", "severity": 2}
{"drug1": "suprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with halcinonide.", "severity": 2}
{"drug1": "butamben", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Pipotiazine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Agomelatine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with efavirenz.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "enflurane", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with MELPERONE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with terbutaline.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with ciprofloxacin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with bezafibrate.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "imipramine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Lurasidone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with thiothixene.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Thioproperazine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Ketobemidone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Pipamperone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Pipotiazine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Etidocaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with zotepine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with pimozide.", "severity": 2}
{"drug1": "amifostine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Sacubitril.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with nimesulide.", "severity": 2}
{"drug1": "thiopental", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with thiamylal.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with butalbital.", "severity": 2}
{"drug1": "terconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with suprofen.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "tolazoline", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with quetiapine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with ESMOLOL.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with ethotoin.", "severity": 2}
{"drug1": "clozapine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with quinapril.", "severity": 2}
{"drug1": "clozapine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with chlorothiazide.", "severity": 2}
{"drug1": "clozapine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Amrinone.", "severity": 2}
{"drug1": "clozapine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with bumetanide.", "severity": 2}
{"drug1": "timolol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "L-tryptophan", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when L-tryptophan is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Tasimelteon.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "hydroxyurea", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyurea is combined with clozapine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with felodipine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "lorazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "furosemide", "drug2": "streptomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with streptomycin.", "severity": 2}
{"drug1": "meperidine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with methoxyflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "butalbital", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Aripiprazole.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with chlorprothixene.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with dexamethasone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Icatibant.", "severity": 2}
{"drug1": "butalbital", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Pomalidomide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with ESMOLOL.", "severity": 2}
{"drug1": "furazolidone", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with formoterol.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with diclofenac.", "severity": 2}
{"drug1": "meprobamate", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with tiapride.", "severity": 2}
{"drug1": "pimozide", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with proparacaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with methoxyflurane.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with amoxapine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "risperidone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with scopolamine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with Apixaban.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with diflorasone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with NITROUS ACID.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with fexofenadine.", "severity": 2}
{"drug1": "epirizole", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Loxoprofen.", "severity": 2}
{"drug1": "meprobamate", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with DESFLURANE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Retigabine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with tizanidine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with sulpiride.", "severity": 2}
{"drug1": "procarbazine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Benidipine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with acebutolol.", "severity": 2}
{"drug1": "furosemide", "drug2": "tobramycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with tobramycin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with captopril.", "severity": 2}
{"drug1": "ketamine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "triamterene", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Bretylium.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Bambuterol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Degarelix", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Degarelix.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with cabergoline.", "severity": 2}
{"drug1": "diflunisal", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with paramethasone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with dexamethasone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Cladribine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Cladribine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with haloperidol.", "severity": 2}
{"drug1": "pargyline", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Enalaprilat.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nitroglycerin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with lisinopril.", "severity": 2}
{"drug1": "tetracaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with scopolamine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Etoricoxib.", "severity": 2}
{"drug1": "flumethasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with tubocurarine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with SERTINDOLE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with trandolapril.", "severity": 2}
{"drug1": "thalidomide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with captopril.", "severity": 2}
{"drug1": "reserpine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with fexofenadine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with teniposide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Epirubicin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with METAXALONE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with levodopa.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Pregabalin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with budesonide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Capsaicin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "MEDROGESTONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with MEDROGESTONE.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with benazepril.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Dienogest", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Dienogest.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with imipramine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with flumethasone.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with Pitavastatin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Apremilast.", "severity": 2}
{"drug1": "minoxidil", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with carvedilol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Regorafenib is combined with atorvastatin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Iloperidone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with procaine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Clevidipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with phenytoin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with resveratrol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when galanthamine is combined with methacholine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Ramelteon.", "severity": 2}
{"drug1": "aspirin", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with salicylamide.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with levodopa.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Cyamemazine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with isoxsuprine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Pizotifen.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with reserpine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with tretinoin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Apixaban.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with tiagabine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "buspirone", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with DESFLURANE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "haloprogin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with vigabatrin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with benzocaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with zonisamide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritonavir is combined with triamcinolone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with tiapride.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "promazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with tiagabine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "clomipramine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "fenbufen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Levetiracetam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with felbamate.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with DEZOCINE.", "severity": 2}
{"drug1": "quinidine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with propoxyphene.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Agomelatine.", "severity": 2}
{"drug1": "propantheline", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with DEZOCINE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with levorphanol.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Olopatadine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with primidone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Agomelatine.", "severity": 2}
{"drug1": "trazodone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with imipramine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with GUANFACINE.", "severity": 2}
{"drug1": "trazodone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with loratadine.", "severity": 2}
{"drug1": "trazodone", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with meperidine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with suprofen.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with loteprednol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with venlafaxine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with clemastine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with chlorthalidone.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with orphenadrine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Canrenoic acid.", "severity": 2}
{"drug1": "triazolam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Iloperidone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nilvadipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with DEZOCINE.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Fospropofol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with midazolam.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with topiramate.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with Pomalidomide.", "severity": 2}
{"drug1": "trazodone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with amitriptyline.", "severity": 2}
{"drug1": "etizolam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "glutethimide", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with citalopram.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with mecamylamine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with paroxetine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with arsenic trioxide.", "severity": 2}
{"drug1": "triprolidine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with ethotoin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with proparacaine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with cilostazol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with trimipramine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with procaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Halazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Ramelteon.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with clonazepam.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with promethazine.", "severity": 2}
{"drug1": "Butethal", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Pinaverium.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with tizanidine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lenalidomide is combined with leflunomide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with maprotiline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Etidronic acid.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with nifedipine.", "severity": 2}
{"drug1": "imipramine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with bumetanide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Clobetasone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with papaverine.", "severity": 2}
{"drug1": "quinidine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfadiazine is combined with prilocaine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with ethanol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with benzocaine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Fencamfamin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with metolazone.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with tubocurarine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with vigabatrin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with Tapentadol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with CYCLIZINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Retigabine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Articaine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with cinnarizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Ramelteon.", "severity": 2}
{"drug1": "felbamate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Levetiracetam.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with clomipramine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Teriflunomide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with penbutolol.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with niflumic acid.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with nicardipine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with baclofen.", "severity": 2}
{"drug1": "propantheline", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with propoxyphene.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with oxycodone.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with sertraline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "loxapine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Oxetacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Empagliflozin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with efavirenz.", "severity": 2}
{"drug1": "loxapine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Remoxipride.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "reserpine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Desloratadine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with oxybutynin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Butethal.", "severity": 2}
{"drug1": "tolazoline", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with hydralazine.", "severity": 2}
{"drug1": "estrone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with nalidixic acid.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Etomidate", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with bupivacaine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Ropivacaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with HEROIN.", "severity": 2}
{"drug1": "estrone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with malathion.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with ethosuximide.", "severity": 2}
{"drug1": "captopril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with niflumic acid.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Teriflunomide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with bromocriptine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Ramelteon.", "severity": 2}
{"drug1": "diflorasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with donepezil.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Difenoxin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetaminophen is combined with atorvastatin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with bupropion.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Pimecrolimus.", "severity": 2}
{"drug1": "ropinirole", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with irbesartan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "cabergoline", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with modafinil.", "severity": 2}
{"drug1": "ropinirole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with felodipine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with meclizine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with oxymorphone.", "severity": 2}
{"drug1": "Limaprost", "drug2": "citric acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with citric acid.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "sertraline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with moclobemide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with tranylcypromine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Luliconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Luliconazole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with fluoxetine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with diflunisal.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with quazepam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with prazepam.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Topiroxostat.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with oxprenolol.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Empagliflozin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Ketobemidone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Articaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Oxetacaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with AMILORIDE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with methyclothiazide.", "severity": 2}
{"drug1": "triamterene", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with nitroglycerin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with mecamylamine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with propoxyphene.", "severity": 2}
{"drug1": "triamterene", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with lisinopril.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with thalidomide.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with doxepin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Lurasidone.", "severity": 2}
{"drug1": "sotalol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with acetylcholine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "hydroxyurea", "drug2": "stavudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyurea is combined with stavudine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Desloratadine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Tasimelteon.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with PERHEXILINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with METAXALONE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Bretylium.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Clevidipine.", "severity": 2}
{"drug1": "benztropine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Conivaptan.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "halothane", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "phenindione", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with phenindione.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with ethchlorvynol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with metoclopramide.", "severity": 2}
{"drug1": "tiapride", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Flibanserin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Lormetazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Milnacipran.", "severity": 2}
{"drug1": "clonazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with duloxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "levorphanol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with butamben.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "enflurane", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ramipril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with sulindac.", "severity": 2}
{"drug1": "timolol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Enalaprilat.", "severity": 2}
{"drug1": "benztropine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Fesoterodine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "enflurane", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Pomalidomide.", "severity": 2}
{"drug1": "timolol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Butethal.", "severity": 2}
{"drug1": "amiodarone", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with reserpine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with DESONIDE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with bromocriptine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Vecuronium.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Pomalidomide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with pancuronium.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "dibucaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with tiapride.", "severity": 2}
{"drug1": "quinapril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Apremilast.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with oxymetazoline.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with ethotoin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Levetiracetam.", "severity": 2}
{"drug1": "donepezil", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when donepezil is combined with Varenicline.", "severity": 2}
{"drug1": "pimozide", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with DEZOCINE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Flupentixol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with efavirenz.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with nimodipine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Fospropofol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with desipramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with chlormezanone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with clomipramine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Iloperidone.", "severity": 2}
{"drug1": "timolol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with enalapril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Escitalopram.", "severity": 2}
{"drug1": "trimipramine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Ramelteon.", "severity": 2}
{"drug1": "nabumetone", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with diflunisal.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with NAPROXEN.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with Vilazodone.", "severity": 2}
{"drug1": "atenolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Clevidipine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "bromazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Empagliflozin.", "severity": 2}
{"drug1": "thiopental", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with prilocaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "procarbazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with MELPERONE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with zotepine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with meclizine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with thioridazine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with Ketobemidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with NICORANDIL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with baclofen.", "severity": 2}
{"drug1": "procaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Asenapine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with diazepam.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Articaine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with loteprednol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with cetirizine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with isoproterenol.", "severity": 2}
{"drug1": "Metixene", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Normethadone.", "severity": 2}
{"drug1": "Trospium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with propoxyphene.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with clindamycin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "pramipexole", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with methazolamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with deslanoside.", "severity": 2}
{"drug1": "methylene blue", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with brimonidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with methocarbamol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with triprolidine.", "severity": 2}
{"drug1": "clozapine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with loxapine.", "severity": 2}
{"drug1": "losartan", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with floctafenine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Lurasidone.", "severity": 2}
{"drug1": "enflurane", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with fluoxetine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Rotigotine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with triprolidine.", "severity": 2}
{"drug1": "enflurane", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with duloxetine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with methocarbamol.", "severity": 2}
{"drug1": "enflurane", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with topiramate.", "severity": 2}
{"drug1": "procaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with etizolam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with glutethimide.", "severity": 2}
{"drug1": "morphine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with fexofenadine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with protriptyline.", "severity": 2}
{"drug1": "Halazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with cetirizine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with dibucaine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Lercanidipine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with felbamate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with donepezil.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "benazepril", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with chlorothiazide.", "severity": 2}
{"drug1": "benazepril", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with quinapril.", "severity": 2}
{"drug1": "pentazocine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with thioridazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with fludiazepam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with chloral hydrate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with methyclothiazide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Etidronic acid.", "severity": 2}
{"drug1": "efavirenz", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Halazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with proparacaine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with felbamate.", "severity": 2}
{"drug1": "butabarbital", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with chlormezanone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Oxetacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Sacubitril.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Clevidipine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with phenobarbital.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Escitalopram.", "severity": 2}
{"drug1": "thiopental", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with etizolam.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Tapentadol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "linezolid", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with clozapine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "nylidrin", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nylidrin is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with enflurane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with flumethasone.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "temazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with meclizine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with cabergoline.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Aceclofenac.", "severity": 2}
{"drug1": "temazepam", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with risperidone.", "severity": 2}
{"drug1": "suprofen", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with ketoprofen.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Ramelteon.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "loxapine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with cetirizine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with amisulpride.", "severity": 2}
{"drug1": "etodolac", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Loxoprofen.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ZILEUTON.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with ketoprofen.", "severity": 2}
{"drug1": "etodolac", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with tolfenamic acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Droxicam.", "severity": 2}
{"drug1": "etodolac", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with CLONIXIN.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Amrinone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with ethosuximide.", "severity": 2}
{"drug1": "quazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "quazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with dyclonine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with medrysone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with amisulpride.", "severity": 2}
{"drug1": "bromazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with tetracaine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Aceprometazine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Olopatadine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with MOLINDONE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Nebivolol.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with diflunisal.", "severity": 2}
{"drug1": "methadone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with D-mannitol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with etodolac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with loratadine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with imipramine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Retigabine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Mometasone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Normethadone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Tramadol.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cilastatin is combined with meperidine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "pimozide", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with METAXALONE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with cetirizine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with tiapride.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with levodopa.", "severity": 2}
{"drug1": "etizolam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with maprotiline.", "severity": 2}
{"drug1": "codeine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with trimipramine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with MOLINDONE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "altretamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with altretamine.", "severity": 2}
{"drug1": "clemastine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with primidone.", "severity": 2}
{"drug1": "codeine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with procaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with bromazepam.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Pefloxacin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with CYCLIZINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Tolcapone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Lenalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Lenalidomide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with amitriptyline.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with dihydroergotamine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Butethal.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with indomethacin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with resveratrol.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Calcium acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with Calcium acetate.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BUPRANOLOL is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with metolazone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with sulfasalazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with eperisone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Telmisartan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with etizolam.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "topiramate", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with methocarbamol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with SERATRODAST.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with apraclonidine.", "severity": 2}
{"drug1": "topiramate", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with triprolidine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with GUANFACINE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with gabapentin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "biperiden", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with buprenorphine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Tixocortol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with isocarboxazid.", "severity": 2}
{"drug1": "triazolam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with fenbufen.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when edrophonium is combined with Varenicline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with procarbazine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Olsalazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Topiroxostat.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "amiodarone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with amiodarone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Propoxycaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Pramocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with nimesulide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with GUANFACINE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Empagliflozin.", "severity": 2}
{"drug1": "nylidrin", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nylidrin is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with epirizole.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Dothiepin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with methyldopa.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Paliperidone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "buspirone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with quetiapine.", "severity": 2}
{"drug1": "buspirone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ketamine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with flurandrenolide.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with thioridazine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Tasimelteon.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with meclizine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Eprosartan.", "severity": 2}
{"drug1": "diflunisal", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with betamethasone.", "severity": 2}
{"drug1": "methysergide", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with tamoxifen.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with spironolactone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Apixaban.", "severity": 2}
{"drug1": "antipyrine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with CLONIXIN.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with nimesulide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with CYCLIZINE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with carprofen.", "severity": 2}
{"drug1": "nimodipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Cis-mdp.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bexarotene is combined with clozapine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with chlormezanone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with mesoridazine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Fluspirilene.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with thioridazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Fluspirilene.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Risedronic acid.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Loxoprofen.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Aceprometazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Empagliflozin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Ropivacaine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with MOLINDONE.", "severity": 2}
{"drug1": "biperiden", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with oxyphenonium.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with clomipramine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with quetiapine.", "severity": 2}
{"drug1": "midazolam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with GUANFACINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with efavirenz.", "severity": 2}
{"drug1": "nabumetone", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with methylprednisolone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Flibanserin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Fluprednidene.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with morphine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with nitrous oxide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with cyclophosphamide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ciprofloxacin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Droxicam.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Clobetasone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Canagliflozin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with salicylamide.", "severity": 2}
{"drug1": "barnidipine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with mecamylamine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with triamcinolone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with difluprednate.", "severity": 2}
{"drug1": "morphine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with nitrous oxide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with halcinonide.", "severity": 2}
{"drug1": "diazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with tiapride.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with triamterene.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with amisulpride.", "severity": 2}
{"drug1": "methysergide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with sertraline.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with nitric oxide.", "severity": 2}
{"drug1": "methysergide", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with pimozide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Vilanterol.", "severity": 2}
{"drug1": "sulindac", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with mycophenolic acid.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Pentolinium.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with naratriptan.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Halobetasol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Riociguat.", "severity": 2}
{"drug1": "butalbital", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with loratadine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with promethazine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Ethylmorphine.", "severity": 2}
{"drug1": "diazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with mecamylamine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Milnacipran.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Salsalate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Flibanserin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Salsalate.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with oxaprozin.", "severity": 2}
{"drug1": "labetalol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with D-mannitol.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with trimipramine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Articaine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Lumiracoxib.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with NITROUS ACID.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with carprofen.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with chloral hydrate.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Tasimelteon.", "severity": 2}
{"drug1": "enflurane", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Fencamfamin.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Nebivolol.", "severity": 2}
{"drug1": "enflurane", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Ethylmorphine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Iloperidone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with triamterene.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Oxetacaine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with clomipramine.", "severity": 2}
{"drug1": "enflurane", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with meclizine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with homoharringtonine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with enoxacin.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with memantine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with duloxetine.", "severity": 2}
{"drug1": "enflurane", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with clomipramine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Deferasirox.", "severity": 2}
{"drug1": "ethotoin", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with fluoxetine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with quetiapine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "morphine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with methyclothiazide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with desoximetasone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with atenolol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Almotriptan.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Bivalirudin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with Bivalirudin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "zotepine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with felbamate.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with toremifene.", "severity": 2}
{"drug1": "tiapride", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with meclizine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Alvimopan.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Linagliptin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with chlorothiazide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Lofexidine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Elbasvir.", "severity": 2}
{"drug1": "atenolol", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with nicardipine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Ketobemidone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Oxetacaine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Pregabalin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with butamben.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with aspirin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "PHENPROCOUMON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Drospirenone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with thiothixene.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLEANDOMYCIN is combined with atorvastatin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with carvedilol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Varenicline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with prochlorperazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with diltiazem.", "severity": 2}
{"drug1": "Spirapril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with indomethacin.", "severity": 2}
{"drug1": "difluprednate", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with mefloquine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "thiotepa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with thiotepa.", "severity": 2}
{"drug1": "clozapine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with chloral hydrate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with fleroxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with baclofen.", "severity": 2}
{"drug1": "clozapine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with glutethimide.", "severity": 2}
{"drug1": "quazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with clozapine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with ondansetron.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Escitalopram.", "severity": 2}
{"drug1": "Articaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Ramelteon.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with selegiline.", "severity": 2}
{"drug1": "Artemether", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Pinaverium.", "severity": 2}
{"drug1": "Articaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with hydrocortisone.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with clomipramine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with flumethasone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Milnacipran.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Ketobemidone.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Propiverine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with primidone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with tizanidine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Zoledronic acid.", "severity": 2}
{"drug1": "procaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with clidinium.", "severity": 2}
{"drug1": "papaverine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with quetiapine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with HEROIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with haloperidol.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with sulfasalazine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with ESMOLOL.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with triamterene.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with efavirenz.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with haloperidol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with triflupromazine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Halobetasol.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Levetiracetam.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Vecuronium.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with niflumic acid.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Desloratadine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with propranolol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with triamcinolone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with acebutolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Difenoxin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with malathion.", "severity": 2}
{"drug1": "pentostatin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentostatin is combined with clozapine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with nalidixic acid.", "severity": 2}
{"drug1": "bepridil", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with atenolol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with histamine.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Pinaverium.", "severity": 2}
{"drug1": "propofol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "pargyline", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Pipamperone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "propofol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Ramelteon.", "severity": 2}
{"drug1": "dibucaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with lithium ion.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Hexobarbital.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with quetiapine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Butethal.", "severity": 2}
{"drug1": "docetaxel", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with irinotecan.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with bumetanide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with thalidomide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with oxprenolol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with efavirenz.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with clidinium.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Apixaban.", "severity": 2}
{"drug1": "zonisamide", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with levodopa.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Etidocaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with losartan.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "ceftriaxone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with ceftriaxone.", "severity": 2}
{"drug1": "nadolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with hydralazine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with topiramate.", "severity": 2}
{"drug1": "tolterodine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with butorphanol.", "severity": 2}
{"drug1": "nadolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Varenicline.", "severity": 2}
{"drug1": "clorazepate", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with pimozide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with terazosin.", "severity": 2}
{"drug1": "buspirone", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with clorazepate.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Lormetazepam.", "severity": 2}
{"drug1": "efavirenz", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with METAXALONE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with formestane.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "clonidine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with captopril.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atazanavir is combined with toremifene.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Levocetirizine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "imipramine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with carvedilol.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atazanavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "azelastine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Escitalopram.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with enalapril.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with diclofenac.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with cetirizine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Pinaverium.", "severity": 2}
{"drug1": "prazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Flibanserin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with benzyl alcohol.", "severity": 2}
{"drug1": "isradipine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with nicardipine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with lisinopril.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with prazosin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with mycophenolic acid.", "severity": 2}
{"drug1": "prazosin", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Triflusal", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Fospropofol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with flurandrenolide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with irbesartan.", "severity": 2}
{"drug1": "promazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Difenoxin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with butalbital.", "severity": 2}
{"drug1": "ondansetron", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Lenalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Lenalidomide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with estazolam.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Lornoxicam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "altretamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with altretamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with dantrolene.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with papaverine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with triprolidine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with flunisolide.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with diltiazem.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Pregabalin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "ceftriaxone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with ceftriaxone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with butalbital.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Levobupivacaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Tasimelteon.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nimodipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with proparacaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Halazepam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with losartan.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with fleroxacin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Normethadone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tamoxifen.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Apremilast.", "severity": 2}
{"drug1": "thiopental", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with halothane.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with ibuprofen.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with atorvastatin.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with diltiazem.", "severity": 2}
{"drug1": "zotepine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with clonidine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Apremilast.", "severity": 2}
{"drug1": "haloperidol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with thiopental.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with sulindac.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Etidocaine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Milnacipran.", "severity": 2}
{"drug1": "secobarbital", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with butorphanol.", "severity": 2}
{"drug1": "methysergide", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with omeprazole.", "severity": 2}
{"drug1": "butalbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methysergide", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with olanzapine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Ketobemidone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "methysergide", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with methadone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with mesoridazine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Lurasidone.", "severity": 2}
{"drug1": "suprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with niflumic acid.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with xylometazoline.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with clidinium.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with nitric oxide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Retigabine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with alprazolam.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with felbamate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with venlafaxine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nisoldipine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with ambenonium.", "severity": 2}
{"drug1": "isoflurane", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with chlorzoxazone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Mersalyl.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with paroxetine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "EDOXABAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with EDOXABAN.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with sertraline.", "severity": 2}
{"drug1": "sulpiride", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with dibucaine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Loxoprofen.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Droxicam.", "severity": 2}
{"drug1": "morniflumate", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with tolfenamic acid.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with topiramate.", "severity": 2}
{"drug1": "morniflumate", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with CLONIXIN.", "severity": 2}
{"drug1": "butalbital", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Fosphenytoin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "indinavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indinavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with flunarizine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Metipranolol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with GUANFACINE.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with nitrendipine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Eplerenone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with oxaprozin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with benazepril.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Ticagrelor.", "severity": 2}
{"drug1": "halothane", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Agomelatine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with thiopental.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Loxoprofen.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Droxicam.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Levocetirizine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with paroxetine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with barnidipine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with flunitrazepam.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with papaverine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with mirtazapine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ifosfamide.", "severity": 2}
{"drug1": "meperidine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with ethosuximide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with DESFLURANE.", "severity": 2}
{"drug1": "temazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with butalbital.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "triazolam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with meclizine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with hydralazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with GUANFACINE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with tizanidine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with furosemide.", "severity": 2}
{"drug1": "procaine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with floctafenine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with meclizine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with risperidone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with acemetacin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with proparacaine.", "severity": 2}
{"drug1": "ketamine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with methoxyflurane.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with polythiazide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Bivalirudin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Bivalirudin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Halazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with metolazone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Propoxycaine.", "severity": 2}
{"drug1": "codeine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with dibucaine.", "severity": 2}
{"drug1": "atenolol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with papaverine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Difenoxin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with tolazoline.", "severity": 2}
{"drug1": "amiodarone", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with fenbufen.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "diltiazem", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with tranylcypromine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with prednisone.", "severity": 2}
{"drug1": "methysergide", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with metyrapone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with selegiline.", "severity": 2}
{"drug1": "midazolam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with dibucaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with haloperidol.", "severity": 2}
{"drug1": "procaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with nefazodone.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with benzphetamine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with isoproterenol.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with ritodrine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with acemetacin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Fencamfamin.", "severity": 2}
{"drug1": "procaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with doxepin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with meclizine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Propoxycaine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with trimipramine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with sertraline.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Pramocaine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with dopamine.", "severity": 2}
{"drug1": "topiramate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Iloperidone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with tretinoin.", "severity": 2}
{"drug1": "desipramine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with procarbazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with meprobamate.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with D-mannitol.", "severity": 2}
{"drug1": "histamine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when histamine is combined with atorvastatin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with formestane.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with PROCATEROL.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with scopolamine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ketamine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with propoxyphene.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Iloperidone.", "severity": 2}
{"drug1": "estazolam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with loratadine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "roxithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with roxithromycin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zafirlukast is combined with atorvastatin.", "severity": 2}
{"drug1": "propofol", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with trandolapril.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Olopatadine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with metaproterenol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with chlormezanone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with CYCLIZINE.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with methylprednisolone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with pargyline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with moclobemide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Agomelatine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with sevoflurane.", "severity": 2}
{"drug1": "citalopram", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with loxapine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amprenavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Pipotiazine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with phenmetrazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Dapagliflozin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with terbutaline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with SUFENTANIL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with enflurane.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with efavirenz.", "severity": 2}
{"drug1": "captopril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with clorazepate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with mesalamine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Levetiracetam.", "severity": 2}
{"drug1": "ketorolac", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with alclometasone.", "severity": 2}
{"drug1": "doxepin", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with celiprolol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "doxepin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with flunarizine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with levodopa.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "gabapentin", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with bromazepam.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Risedronic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Halobetasol.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with butamben.", "severity": 2}
{"drug1": "flurazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with doxepin.", "severity": 2}
{"drug1": "codeine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Pipamperone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with chlormezanone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with sulfasalazine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "prazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with zotepine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with betamethasone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with tenoxicam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with fleroxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with amcinonide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with nabumetone.", "severity": 2}
{"drug1": "butamben", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Flibanserin.", "severity": 2}
{"drug1": "halothane", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with METAXALONE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ketorolac.", "severity": 2}
{"drug1": "Salsalate", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Olopatadine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with biperiden.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with clozapine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with triflupromazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with doxepin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with nefazodone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Tolvaptan.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Amrinone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with fluoxetine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with mepivacaine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with zonisamide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Desloratadine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with amoxapine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Fosphenytoin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with pramipexole.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with tiagabine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Perospirone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with methyclothiazide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with apraclonidine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with sevoflurane.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with BISOPROLOL.", "severity": 2}
{"drug1": "bromazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with baclofen.", "severity": 2}
{"drug1": "ipratropium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with oxycodone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with levorphanol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with losartan.", "severity": 2}
{"drug1": "butabarbital", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with perphenazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with zaltoprofen.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Aceclofenac.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with SERATRODAST.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with ondansetron.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with tiagabine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with equilin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "timolol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with cilazapril.", "severity": 2}
{"drug1": "meclizine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with citalopram.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "diclofenac", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with indomethacin.", "severity": 2}
{"drug1": "temazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with tizanidine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with flunarizine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with NAPROXEN.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with methyldopa.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with lithium ion.", "severity": 2}
{"drug1": "Artemether", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with eperisone.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with methscopolamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Levetiracetam.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with ramipril.", "severity": 2}
{"drug1": "meperidine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with DEZOCINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with vigabatrin.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clarithromycin is combined with Abemaciclib.", "severity": 2}
{"drug1": "difluprednate", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with decamethonium.", "severity": 2}
{"drug1": "betaxolol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with D-mannitol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with zotepine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with DESFLURANE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with chlorothiazide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with chloral hydrate.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with fludiazepam.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with oxaprozin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with penbutolol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Alvimopan.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with nifedipine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with levodopa.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with memantine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with nortriptyline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with phenobarbital.", "severity": 2}
{"drug1": "antipyrine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Tapentadol.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Ecabet", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ecabet is combined with meperidine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with triamcinolone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Fluspirilene.", "severity": 2}
{"drug1": "zaleplon", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with chlorprothixene.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with formestane.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Riociguat.", "severity": 2}
{"drug1": "salicylamide", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with flurandrenolide.", "severity": 2}
{"drug1": "estazolam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Varenicline.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with resveratrol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with periciazine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with oxazepam.", "severity": 2}
{"drug1": "etizolam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Lormetazepam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with MELPERONE.", "severity": 2}
{"drug1": "thiopental", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Pipamperone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Perospirone.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "brimonidine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with isoxsuprine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nicergoline", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with metyrapone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with carprofen.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with flunarizine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with glyburide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with tolazoline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with decamethonium.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "diazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Perospirone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Risedronic acid.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Lormetazepam.", "severity": 2}
{"drug1": "atenolol", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with minoxidil.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Normethadone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with mesalamine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Halobetasol.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Levetiracetam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with butalbital.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Normethadone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Remoxipride.", "severity": 2}
{"drug1": "haloperidol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with dyclonine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with baclofen.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Aceprometazine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Riociguat.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with MOLINDONE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with ethchlorvynol.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Pomalidomide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with tiapride.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Pramocaine.", "severity": 2}
{"drug1": "baclofen", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with carisoprodol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Propoxycaine.", "severity": 2}
{"drug1": "halothane", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with zotepine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with fexofenadine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with biperiden.", "severity": 2}
{"drug1": "procaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "pergolide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with ethanol.", "severity": 2}
{"drug1": "epirizole", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with budesonide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with lithium ion.", "severity": 2}
{"drug1": "codeine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Hexobarbital.", "severity": 2}
{"drug1": "codeine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with lithium ion.", "severity": 2}
{"drug1": "etodolac", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "etodolac", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Fluprednidene.", "severity": 2}
{"drug1": "codeine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Butethal.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Phenelzine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with dyclonine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "phenindione", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with phenindione.", "severity": 2}
{"drug1": "sulpiride", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with propoxyphene.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with desipramine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with alclofenac.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with clidinium.", "severity": 2}
{"drug1": "estazolam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with mesoridazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with prazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with quazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with oxprenolol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with tolterodine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with KETAZOLAM.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with nitroglycerin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with butalbital.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with oxymorphone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with fexofenadine.", "severity": 2}
{"drug1": "midazolam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with dyclonine.", "severity": 2}
{"drug1": "midazolam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with propoxyphene.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Metixene.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with diltiazem.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Levetiracetam.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with apraclonidine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with droperidol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with levorphanol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with loratadine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyridostigmine is combined with pilocarpine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with papaverine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Metixene.", "severity": 2}
{"drug1": "isradipine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with enalapril.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Lercanidipine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with clonidine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Lomitapide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with propranolol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Ivacaftor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Ivacaftor.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with oxprenolol.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Lormetazepam.", "severity": 2}
{"drug1": "ketamine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Paliperidone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tranylcypromine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tretinoin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with donepezil.", "severity": 2}
{"drug1": "thiothixene", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with mepivacaine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Lumiracoxib.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with carbamazepine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Risedronic acid.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Desloratadine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Empagliflozin.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with simvastatin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with isoxsuprine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Etidocaine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "ofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with ofloxacin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with prazepam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with procarbazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with arsenic trioxide.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with imipramine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with nimesulide.", "severity": 2}
{"drug1": "reserpine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with DESFLURANE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Lurasidone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with clozapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with citalopram.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "reserpine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with isradipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with topiramate.", "severity": 2}
{"drug1": "reserpine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Olmesartan.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Levocetirizine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with clonidine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with selegiline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with topiramate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Bambuterol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Asenapine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with daunorubicin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with clenbuterol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with apraclonidine.", "severity": 2}
{"drug1": "Amrinone", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with Pitavastatin.", "severity": 2}
{"drug1": "promazine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with butorphanol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Olopatadine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with thiothixene.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Thioproperazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with promethazine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Retigabine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with maprotiline.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with maprotiline.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Halobetasol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with selegiline.", "severity": 2}
{"drug1": "alprazolam", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with quazepam.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with codeine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with sertraline.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with halcinonide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Fencamfamin.", "severity": 2}
{"drug1": "midazolam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with zopiclone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with difluprednate.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with levodopa.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with desipramine.", "severity": 2}
{"drug1": "pergolide", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with bifonazole.", "severity": 2}
{"drug1": "enalapril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with apraclonidine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Tixocortol.", "severity": 2}
{"drug1": "enalapril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with methyldopa.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Retigabine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nisoldipine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with flunisolide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with estrone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with tolazoline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with loteprednol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with propofol.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with Temsirolimus.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "enalapril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with dipyridamole.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Propiverine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with clidinium.", "severity": 2}
{"drug1": "nabumetone", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Mersalyl.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with meperidine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with procaine.", "severity": 2}
{"drug1": "clonidine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with zonisamide.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Articaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with carisoprodol.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "tegafur", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levoleucovorin is combined with tegafur.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with promethazine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "losartan", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Bretylium.", "severity": 2}
{"drug1": "perphenazine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with triflupromazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with isoxsuprine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with tretinoin.", "severity": 2}
{"drug1": "ethanol", "drug2": "ethionamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with ethionamide.", "severity": 2}
{"drug1": "barnidipine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with isoflurane.", "severity": 2}
{"drug1": "barnidipine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with tranylcypromine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with meclizine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with sotalol.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with nortriptyline.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with amoxapine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with brimonidine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Nabilone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with clomipramine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with GUANFACINE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with chlormezanone.", "severity": 2}
{"drug1": "midazolam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with quetiapine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Escitalopram.", "severity": 2}
{"drug1": "midazolam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with ketamine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with deslanoside.", "severity": 2}
{"drug1": "cefotetan", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cefotetan is combined with ethanol.", "severity": 2}
{"drug1": "zotepine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Flibanserin.", "severity": 2}
{"drug1": "enflurane", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Flibanserin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Lercanidipine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with thiamylal.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with epirizole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with halothane.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Caspofungin.", "severity": 2}
{"drug1": "atenolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with floctafenine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "gemcitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with gemcitabine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with baclofen.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with metformin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with haloperidol.", "severity": 2}
{"drug1": "clidinium", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with GUANFACINE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with nimodipine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with flunarizine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with ondansetron.", "severity": 2}
{"drug1": "lorazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with cocaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with tiagabine.", "severity": 2}
{"drug1": "methadone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Aceprometazine.", "severity": 2}
{"drug1": "budesonide", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with ROSOXACIN.", "severity": 2}
{"drug1": "flurazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with clonidine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with cilazapril.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with propranolol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "L-phenylalanine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with L-phenylalanine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "propofol", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with amobarbital.", "severity": 2}
{"drug1": "Spirapril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with celecoxib.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with hydrocortisone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Cis-mdp.", "severity": 2}
{"drug1": "sotalol", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with trandolapril.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with apraclonidine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Difenoxin.", "severity": 2}
{"drug1": "metolazone", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with fosinopril.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with tiagabine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with zonisamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with reserpine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with leflunomide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with clidinium.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with butalbital.", "severity": 2}
{"drug1": "zaleplon", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with bromazepam.", "severity": 2}
{"drug1": "lisinopril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with domperidone.", "severity": 2}
{"drug1": "butamben", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with METAXALONE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "pramipexole", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with labetalol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Fluspirilene.", "severity": 2}
{"drug1": "pramipexole", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with AMILORIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with maprotiline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Lumiracoxib.", "severity": 2}
{"drug1": "pramipexole", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with doxazosin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with carvedilol.", "severity": 2}
{"drug1": "trazodone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Propoxycaine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with flunisolide.", "severity": 2}
{"drug1": "Butethal", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Fosphenytoin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with ethosuximide.", "severity": 2}
{"drug1": "loratadine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with atorvastatin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with etizolam.", "severity": 2}
{"drug1": "HEROIN", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with AMILORIDE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with chlormezanone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Escitalopram.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apixaban is combined with Temsirolimus.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with antipyrine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Levomepromazine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with halcinonide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with flurazepam.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Escitalopram.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with difluprednate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with chloroquine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with GUANFACINE.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with dobutamine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with thiopental.", "severity": 2}
{"drug1": "leflunomide", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with CLONIXIN.", "severity": 2}
{"drug1": "benztropine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with tubocurarine.", "severity": 2}
{"drug1": "tiapride", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with levodopa.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Loxoprofen.", "severity": 2}
{"drug1": "azelastine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Risedronic acid.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Tapentadol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Pramocaine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Risedronic acid.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Droxicam.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with flunarizine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Fluspirilene.", "severity": 2}
{"drug1": "carprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with haloperidol.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Eplerenone.", "severity": 2}
{"drug1": "butalbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with carisoprodol.", "severity": 2}
{"drug1": "risperidone", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with oxazepam.", "severity": 2}
{"drug1": "Nabilone", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with resveratrol.", "severity": 2}
{"drug1": "methysergide", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with isoniazid.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Metipranolol.", "severity": 2}
{"drug1": "indapamide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Iloperidone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with desipramine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with topiramate.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Apremilast.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with gabapentin.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Pipotiazine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with venlafaxine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with NICORANDIL.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with meclizine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with nadolol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "thioguanine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with thioguanine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Lorcaserin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with meclofenamic acid.", "severity": 2}
{"drug1": "docetaxel", "drug2": "MEGESTROL ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "aminoglutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with aminoglutethimide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "LYCOPENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with LYCOPENE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with trimipramine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with nifedipine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with etizolam.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Propacetamol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with papaverine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Metipranolol.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Ramelteon.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Propacetamol.", "severity": 2}
{"drug1": "fenbufen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with loteprednol.", "severity": 2}
{"drug1": "captopril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with carprofen.", "severity": 2}
{"drug1": "procarbazine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with isoetharine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with proparacaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Butethal", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Retigabine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Tasimelteon.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with dantrolene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with gabapentin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with methylphenidate.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Remoxipride.", "severity": 2}
{"drug1": "betamethasone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with atorvastatin.", "severity": 2}
{"drug1": "propofol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with thiamylal.", "severity": 2}
{"drug1": "Etomidate", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with pentazocine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Phenelzine.", "severity": 2}
{"drug1": "promazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "pergolide", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with sulfanilamide.", "severity": 2}
{"drug1": "propofol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with halothane.", "severity": 2}
{"drug1": "propofol", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Bretylium.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with MELPERONE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "propranolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with cilazapril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with indomethacin.", "severity": 2}
{"drug1": "medrysone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Pefloxacin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with enoxacin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with oxaprozin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with losartan.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Pitavastatin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with sevoflurane.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Lornoxicam.", "severity": 2}
{"drug1": "tizanidine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with fexofenadine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "aspirin", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with triamcinolone.", "severity": 2}
{"drug1": "formestane", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with galanthamine.", "severity": 2}
{"drug1": "formestane", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Isoflurophate.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with clidinium.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with hydralazine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with chlorothiazide.", "severity": 2}
{"drug1": "Normethadone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with meclizine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Butethal.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with bumetanide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Perospirone.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Pitavastatin.", "severity": 2}
{"drug1": "suprofen", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with niflumic acid.", "severity": 2}
{"drug1": "nystatin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Lacidipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with chlorthalidone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Pipotiazine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Thioproperazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Levetiracetam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Fospropofol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with diphenhydramine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Fospropofol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "azelastine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Clodronic Acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with niflumic acid.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Tramadol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Canagliflozin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with bumetanide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with nimesulide.", "severity": 2}
{"drug1": "azelastine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Cis-mdp.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with mesoridazine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with maprotiline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with chlorothiazide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with triamterene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Halazepam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with zonisamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with SUFENTANIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with fexofenadine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with tetracaine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Zucapsaicin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Normethadone.", "severity": 2}
{"drug1": "propofol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with isoxsuprine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with malathion.", "severity": 2}
{"drug1": "tolterodine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with nalbuphine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with PAMABROM.", "severity": 2}
{"drug1": "methysergide", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with bicalutamide.", "severity": 2}
{"drug1": "etoposide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etoposide is combined with atorvastatin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with trichlormethiazide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with felodipine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with irbesartan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with methoxyflurane.", "severity": 2}
{"drug1": "propofol", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with zopiclone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with topiramate.", "severity": 2}
{"drug1": "dobutamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with methylprednisolone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with nimodipine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Zoledronic acid.", "severity": 2}
{"drug1": "methysergide", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with rabeprazole.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with venlafaxine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Difenoxin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with penbutolol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Olopatadine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with citalopram.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Carbamylcholine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with ethotoin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with minoxidil.", "severity": 2}
{"drug1": "dyclonine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with protriptyline.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with nilvadipine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with chlorpheniramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with MELPERONE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with nadolol.", "severity": 2}
{"drug1": "zotepine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with trimipramine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with felbamate.", "severity": 2}
{"drug1": "epinephrine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "enflurane", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with etizolam.", "severity": 2}
{"drug1": "risperidone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Flibanserin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with fenoldopam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Etoricoxib.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with cinnarizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "isoflurane", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with chlormezanone.", "severity": 2}
{"drug1": "azelastine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with salicylamide.", "severity": 2}
{"drug1": "codeine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with nitrazepam.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with clonazepam.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Iloperidone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with paroxetine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Pomalidomide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Melatonin.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Trospium.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ESMOLOL.", "severity": 2}
{"drug1": "morphine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Sacubitril.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with trazodone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Canagliflozin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Clodronic Acid.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with ketamine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with flunarizine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with enflurane.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Flibanserin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with Nintedanib.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Fluprednidene.", "severity": 2}
{"drug1": "fosinopril", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with furosemide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with metronidazole.", "severity": 2}
{"drug1": "diflunisal", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with antipyrine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with indomethacin.", "severity": 2}
{"drug1": "indapamide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with cilazapril.", "severity": 2}
{"drug1": "butabarbital", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with thioridazine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with prazosin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bevantolol is combined with acetylcholine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Remoxipride.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with indomethacin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Pramocaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with isocarboxazid.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Articaine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Difenoxin.", "severity": 2}
{"drug1": "clozapine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with cetirizine.", "severity": 2}
{"drug1": "propofol", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with fosinopril.", "severity": 2}
{"drug1": "selegiline", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Arformoterol.", "severity": 2}
{"drug1": "Salsalate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with diltiazem.", "severity": 2}
{"drug1": "bumetanide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with terazosin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with ketoprofen.", "severity": 2}
{"drug1": "temazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Perospirone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "floctafenine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with amoxapine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Butethal.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with oxprenolol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Melatonin.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with triflupromazine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with acemetacin.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Pitavastatin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with prazepam.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with haloperidol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Hexobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Loxoprofen.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Pipotiazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with lithium ion.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with CLONIXIN.", "severity": 2}
{"drug1": "captopril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with resveratrol.", "severity": 2}
{"drug1": "tioconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with gabapentin.", "severity": 2}
{"drug1": "prazosin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Clevidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with chlormezanone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with scopolamine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Levocetirizine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Retigabine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with triflupromazine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with hydromorphone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Torasemide.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with diclofenac.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with enalapril.", "severity": 2}
{"drug1": "risperidone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with fexofenadine.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with nisoldipine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "warfarin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with warfarin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with clidinium.", "severity": 2}
{"drug1": "triazolam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with duloxetine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Lormetazepam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "estazolam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with sulpiride.", "severity": 2}
{"drug1": "tioconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with propofol.", "severity": 2}
{"drug1": "estazolam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with carisoprodol.", "severity": 2}
{"drug1": "ritodrine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with metoclopramide.", "severity": 2}
{"drug1": "triazolam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with fluoxetine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with amoxapine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "sulconazole", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with lovastatin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with procarbazine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with tamoxifen.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Delavirdine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Delavirdine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Trospium.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Normethadone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Salmeterol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with haloperidol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Echothiophate.", "severity": 2}
{"drug1": "nimodipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with oxycodone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with oxymorphone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Melatonin.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Iloperidone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Olmesartan.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with clonazepam.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with paramethasone.", "severity": 2}
{"drug1": "estazolam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with propoxyphene.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with chlorzoxazone.", "severity": 2}
{"drug1": "diazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with meclizine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with terazosin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with proparacaine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "propofol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with trimipramine.", "severity": 2}
{"drug1": "propofol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with procaine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with betamethasone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Halazepam.", "severity": 2}
{"drug1": "Salsalate", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with prednisone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with estazolam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nadolol.", "severity": 2}
{"drug1": "diazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with fexofenadine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with rasagiline.", "severity": 2}
{"drug1": "propofol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with HEROIN.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Halazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with amobarbital.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with phenytoin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with trifluoperazine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Hexobarbital.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with proparacaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with cilazapril.", "severity": 2}
{"drug1": "biperiden", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Vecuronium.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with indapamide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with BISOPROLOL.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Bretylium.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with furazolidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Telaprevir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Telaprevir.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ramipril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nabumetone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Flupentixol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with prilocaine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with pyridostigmine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with ethotoin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Flibanserin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "clonazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with clozapine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Dapagliflozin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "enflurane", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with prazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with zonisamide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "enflurane", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with oxprenolol.", "severity": 2}
{"drug1": "captopril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with zaltoprofen.", "severity": 2}
{"drug1": "diltiazem", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with terazosin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with salicylic acid.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with tolfenamic acid.", "severity": 2}
{"drug1": "barnidipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with meclofenamic acid.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with METAXALONE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with mefenamic acid.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Aceclofenac.", "severity": 2}
{"drug1": "tretinoin", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with chlorthalidone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with ibuprofen.", "severity": 2}
{"drug1": "cocaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "halothane", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "halothane", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "halothane", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nitric oxide.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Oxetacaine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Desloratadine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with levorphanol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with mepivacaine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with Apixaban.", "severity": 2}
{"drug1": "quinapril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Teriflunomide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with lithium ion.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Aceprometazine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with ketoprofen.", "severity": 2}
{"drug1": "prazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with trimipramine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spiramycin is combined with pravastatin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bivalirudin is combined with Nintedanib.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with flunisolide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "levorphanol", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with nitrazepam.", "severity": 2}
{"drug1": "enflurane", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with baclofen.", "severity": 2}
{"drug1": "indomethacin", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with antipyrine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with nisoldipine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "miconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "estrone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "metaraminol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with metaraminol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with clozapine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfapyridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfapyridine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Iloperidone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "floxuridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with floxuridine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with lidocaine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with galanthamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Rotigotine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with MOLINDONE.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Propiverine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with flurandrenolide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with sertraline.", "severity": 2}
{"drug1": "nimesulide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with atorvastatin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Aceprometazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with lithium ion.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Etoricoxib.", "severity": 2}
{"drug1": "felbamate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Levocetirizine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Riociguat.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with topiramate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with halcinonide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with benzocaine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with sumatriptan.", "severity": 2}
{"drug1": "clorazepate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with vigabatrin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with difluprednate.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Olopatadine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with felbamate.", "severity": 2}
{"drug1": "levodopa", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "reserpine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with zotepine.", "severity": 2}
{"drug1": "Trospium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with DEZOCINE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "baclofen", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with imipramine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with chlorzoxazone.", "severity": 2}
{"drug1": "methadone", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with SUFENTANIL.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with memantine.", "severity": 2}
{"drug1": "epirizole", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with DESFLURANE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with desipramine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Pipamperone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with flunarizine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Halazepam.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with niflumic acid.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "clozapine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with proparacaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ramipril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with mecamylamine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Lacidipine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with aspirin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Milnacipran.", "severity": 2}
{"drug1": "Naftifine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with acemetacin.", "severity": 2}
{"drug1": "morphine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with dyclonine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "morphine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with propoxyphene.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Azelnidipine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Aripiprazole.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with benzocaine.", "severity": 2}
{"drug1": "methadone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with topiramate.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with procarbazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with tranylcypromine.", "severity": 2}
{"drug1": "Articaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with desipramine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Sacubitril.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with tetracycline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with pimozide.", "severity": 2}
{"drug1": "cetirizine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with meclizine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Pirlindole.", "severity": 2}
{"drug1": "enalapril", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with D-mannitol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with flurazepam.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with digitoxin.", "severity": 2}
{"drug1": "enalapril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with etodolac.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Paliperidone.", "severity": 2}
{"drug1": "propofol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with butamben.", "severity": 2}
{"drug1": "pimozide", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with carisoprodol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Mephobarbital.", "severity": 2}
{"drug1": "benzocaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with chlormezanone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with perphenazine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with levorphanol.", "severity": 2}
{"drug1": "dobutamine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with benzphetamine.", "severity": 2}
{"drug1": "dobutamine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with ritodrine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "linezolid", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with benzocaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with nitrazepam.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with NICORANDIL.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Fesoterodine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with carvedilol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with ESMOLOL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with furosemide.", "severity": 2}
{"drug1": "propantheline", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Propiverine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with prednisone.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with nifedipine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "brotizolam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with paroxetine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with baclofen.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Pipotiazine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Olopatadine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Etoricoxib.", "severity": 2}
{"drug1": "meprobamate", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with carisoprodol.", "severity": 2}
{"drug1": "quazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with sulpiride.", "severity": 2}
{"drug1": "Apremilast", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with epirizole.", "severity": 2}
{"drug1": "quazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Hexobarbital.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with betaxolol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with desipramine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with flunitrazepam.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Clevidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with clonazepam.", "severity": 2}
{"drug1": "reserpine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with promethazine.", "severity": 2}
{"drug1": "methadone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with oxprenolol.", "severity": 2}
{"drug1": "epirizole", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Etidronic acid.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Dabigatran etexilate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with flunitrazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with polythiazide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with prochlorperazine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with papaverine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with MELPERONE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with nifedipine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with enflurane.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with topiramate.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with AMILORIDE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with flunitrazepam.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with doxazosin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Ramelteon.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with mesoridazine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with labetalol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with sulpiride.", "severity": 2}
{"drug1": "methadone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with codeine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with progesterone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Bretylium.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Sorafenib.", "severity": 2}
{"drug1": "buspirone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "methadone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with baclofen.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Retigabine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with captopril.", "severity": 2}
{"drug1": "ambenonium", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambenonium is combined with methacholine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Droxicam", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with formestane.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with flumethasone.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Pomalidomide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with tiagabine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with ondansetron.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with clozapine.", "severity": 2}
{"drug1": "tibolone", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tibolone is combined with Ospemifene.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with zonisamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with zopiclone.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with scopolamine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with clonidine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with D-mannitol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Pizotifen.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Desloratadine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Perospirone.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Ramelteon.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with doxepin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with felbamate.", "severity": 2}
{"drug1": "leflunomide", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with tolfenamic acid.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Pomalidomide.", "severity": 2}
{"drug1": "diazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with duloxetine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with glutethimide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "trazodone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Phenelzine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Ramelteon.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Thioproperazine.", "severity": 2}
{"drug1": "clemastine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "morphine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Flibanserin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with clofazimine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with quinidine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Masoprocol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ramipril.", "severity": 2}
{"drug1": "topiramate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Retigabine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with maprotiline.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Carbetocin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Dapagliflozin.", "severity": 2}
{"drug1": "methadone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Articaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "colchicine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with colchicine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with mesoridazine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Pipamperone.", "severity": 2}
{"drug1": "methadone", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Cyamemazine.", "severity": 2}
{"drug1": "methadone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with metolazone.", "severity": 2}
{"drug1": "methadone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with dibucaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with hydrocortisone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Oxetacaine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Amrinone.", "severity": 2}
{"drug1": "methysergide", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with modafinil.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with alclometasone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Fludarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Fludarabine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with paroxetine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with reserpine.", "severity": 2}
{"drug1": "aspirin", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with desoximetasone.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Isotretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlortetracycline is combined with Isotretinoin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "Topiroxostat", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Topiroxostat is combined with atorvastatin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with chlorprothixene.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with nimodipine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Tolcapone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Zoledronic acid.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with metoclopramide.", "severity": 2}
{"drug1": "pimozide", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Oxetacaine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with propoxyphene.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with ethotoin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Difenoxin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with butalbital.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with chlormezanone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with amitriptyline.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Desloratadine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Nitroprusside.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with nitroglycerin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with captopril.", "severity": 2}
{"drug1": "metoprolol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with lisinopril.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with acebutolol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with tenoxicam.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with donepezil.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Apremilast.", "severity": 2}
{"drug1": "promethazine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with procarbazine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with prilocaine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with tranylcypromine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with ethotoin.", "severity": 2}
{"drug1": "losartan", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with D-mannitol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with proparacaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Halazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Olopatadine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Lornoxicam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with procarbazine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with chlormezanone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with CLONIXIN.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Normethadone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Droxicam.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with tolfenamic acid.", "severity": 2}
{"drug1": "minoxidil", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with prazosin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Lacidipine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with tetracaine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Loxoprofen.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Aliskiren.", "severity": 2}
{"drug1": "trimipramine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with clonidine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with Canagliflozin.", "severity": 2}
{"drug1": "promethazine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Lorcaserin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "zotepine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with phenytoin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Tixocortol.", "severity": 2}
{"drug1": "Articaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Hexobarbital.", "severity": 2}
{"drug1": "nicardipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "etizolam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with GUANFACINE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Metipranolol.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with MOLINDONE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with flunarizine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Pipotiazine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "sulindac", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with antipyrine.", "severity": 2}
{"drug1": "etizolam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Olopatadine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Aceprometazine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with bepridil.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with niflumic acid.", "severity": 2}
{"drug1": "procarbazine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with amisulpride.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with OLODATEROL.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Naloxegol.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Etoricoxib.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Mometasone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with enflurane.", "severity": 2}
{"drug1": "Etomidate", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with citalopram.", "severity": 2}
{"drug1": "flurazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with loteprednol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Gallium nitrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Gallium nitrate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with baclofen.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with isoproterenol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with efavirenz.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with captopril.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with meclizine.", "severity": 2}
{"drug1": "imipramine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with amoxapine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with acebutolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with butamben.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with butamben.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with etizolam.", "severity": 2}
{"drug1": "alclometasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with mefloquine.", "severity": 2}
{"drug1": "zotepine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with pravastatin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with Tasimelteon.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "estrone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Pefloxacin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "estrone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Perospirone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with methyldopa.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Cariprazine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with benazepril.", "severity": 2}
{"drug1": "pramipexole", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with apraclonidine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Telmisartan.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Naftifine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "reserpine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "amifostine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with nitric oxide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with norfloxacin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Calcium acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with Calcium acetate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with etizolam.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with floctafenine.", "severity": 2}
{"drug1": "imipramine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with propranolol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Pimecrolimus.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Difenoxin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with histamine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "nimesulide", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with fluocinonide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with baclofen.", "severity": 2}
{"drug1": "codeine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with fexofenadine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with indapamide.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with cyclophosphamide.", "severity": 2}
{"drug1": "tiapride", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with chlorzoxazone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with nitrous oxide.", "severity": 2}
{"drug1": "losartan", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with homoharringtonine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with flumethasone.", "severity": 2}
{"drug1": "trazodone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with flunarizine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Fluspirilene.", "severity": 2}
{"drug1": "fenbufen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with alclometasone.", "severity": 2}
{"drug1": "trapidil", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with mesalamine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with tubocurarine.", "severity": 2}
{"drug1": "tiapride", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with GUANFACINE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with prochlorperazine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with oxymorphone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with brotizolam.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with doxepin.", "severity": 2}
{"drug1": "triamterene", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with fosinopril.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Toloxatone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Teriflunomide.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with suprofen.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with rasagiline.", "severity": 2}
{"drug1": "lisinopril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with cilazapril.", "severity": 2}
{"drug1": "Articaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with dantrolene.", "severity": 2}
{"drug1": "pramipexole", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with triamterene.", "severity": 2}
{"drug1": "cabergoline", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with linezolid.", "severity": 2}
{"drug1": "buspirone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with quazepam.", "severity": 2}
{"drug1": "procaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Iloperidone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with sertraline.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with clopidogrel.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with prazepam.", "severity": 2}
{"drug1": "ethanol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with atorvastatin.", "severity": 2}
{"drug1": "Sapropterin", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sapropterin is combined with levodopa.", "severity": 2}
{"drug1": "ramipril", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with reserpine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with clemastine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with lisinopril.", "severity": 2}
{"drug1": "betaxolol", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with propranolol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Thioproperazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Nebivolol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with tenoxicam.", "severity": 2}
{"drug1": "Halazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with scopolamine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with malathion.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "protriptyline", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with CYCLIZINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Escitalopram.", "severity": 2}
{"drug1": "ondansetron", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with flunitrazepam.", "severity": 2}
{"drug1": "Mometasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with galanthamine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "carprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with equilin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with papaverine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with KETAZOLAM.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nifedipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with olanzapine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with clidinium.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Etidocaine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Teriflunomide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with pyridostigmine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Normethadone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with difluprednate.", "severity": 2}
{"drug1": "Nabilone", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with tretinoin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with halcinonide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Asenapine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Lacidipine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with flunisolide.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with hydralazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Olmesartan.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Flibanserin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with topiramate.", "severity": 2}
{"drug1": "etizolam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Pizotifen.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with methazolamide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with decamethonium.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Spirapril.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Oxetacaine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with tiagabine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with zonisamide.", "severity": 2}
{"drug1": "halothane", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with methyclothiazide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Perospirone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with cilazapril.", "severity": 2}
{"drug1": "olanzapine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Butethal", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with efavirenz.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with baclofen.", "severity": 2}
{"drug1": "butorphanol", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with nalbuphine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with oxazepam.", "severity": 2}
{"drug1": "tolterodine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with morphine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Salmeterol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with amcinonide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with maprotiline.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Tasimelteon.", "severity": 2}
{"drug1": "thioridazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Remoxipride.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bivalirudin is combined with Deferasirox.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with diltiazem.", "severity": 2}
{"drug1": "ramipril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with azelastine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with methyclothiazide.", "severity": 2}
{"drug1": "ramipril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with dipyridamole.", "severity": 2}
{"drug1": "clidinium", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with tiagabine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with thiamylal.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Olmesartan.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Cis-mdp.", "severity": 2}
{"drug1": "quetiapine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with resveratrol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Estrone sulfate.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with promethazine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Pomalidomide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with mepivacaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with dantrolene.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Estrone sulfate.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with simvastatin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with protriptyline.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with carvedilol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with cetirizine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Riociguat.", "severity": 2}
{"drug1": "alclofenac", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with fludrocortisone.", "severity": 2}
{"drug1": "etodolac", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Tasimelteon.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with acemetacin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Masoprocol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with proparacaine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with zotepine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with MELPERONE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with penbutolol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Halazepam.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with mesalamine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with etizolam.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Avanafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Avanafil.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with clomipramine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with epirizole.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with pentazocine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with promethazine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with clonazepam.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Tasimelteon.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Aceclofenac.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Escitalopram.", "severity": 2}
{"drug1": "butorphanol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with SERATRODAST.", "severity": 2}
{"drug1": "halothane", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with tiagabine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Desloratadine.", "severity": 2}
{"drug1": "halothane", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with AMILORIDE.", "severity": 2}
{"drug1": "ketamine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with baclofen.", "severity": 2}
{"drug1": "ketamine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfisoxazole is combined with mecamylamine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "theophylline", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when theophylline is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with fenoprofen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with vinblastine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with Olsalazine.", "severity": 2}
{"drug1": "azelastine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with nimesulide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RANOLAZINE is combined with oxycodone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with DESFLURANE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with SERTINDOLE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Perospirone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with etizolam.", "severity": 2}
{"drug1": "epirizole", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with haloperidol.", "severity": 2}
{"drug1": "misoprostol", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when misoprostol is combined with Carbetocin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "benazepril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with reserpine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with sulpiride.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Rilpivirine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Rilpivirine.", "severity": 2}
{"drug1": "morphine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Agomelatine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Empagliflozin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with sevoflurane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with tiapride.", "severity": 2}
{"drug1": "Butethal", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Fospropofol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Articaine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with triamcinolone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Aripiprazole.", "severity": 2}
{"drug1": "Nelarabine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nelarabine is combined with clozapine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with terazosin.", "severity": 2}
{"drug1": "terbutaline", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with isoxsuprine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with MOLINDONE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Aceprometazine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with flunitrazepam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "topiramate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with paroxetine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with Mirabegron.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with efavirenz.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Lumiracoxib.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Pipotiazine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Lumiracoxib.", "severity": 2}
{"drug1": "midazolam", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with perphenazine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Empagliflozin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with tizanidine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "apomorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with apomorphine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Olmesartan.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with topiramate.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with isradipine.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PENTAERYTHRITOL TETRANITRATE is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "valsartan", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with salicylamide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "reserpine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Paliperidone.", "severity": 2}
{"drug1": "prazosin", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with D-mannitol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with paroxetine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Fluprednidene.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with promethazine.", "severity": 2}
{"drug1": "loxapine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with trimipramine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with haloperidol.", "severity": 2}
{"drug1": "loxapine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with procaine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Estrone sulfate.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with sulindac.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Oxetacaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with benzocaine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with mecamylamine.", "severity": 2}
{"drug1": "triazolam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with vigabatrin.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with loratadine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with imipramine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with thiothixene.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with budesonide.", "severity": 2}
{"drug1": "morniflumate", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with celecoxib.", "severity": 2}
{"drug1": "codeine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with methyclothiazide.", "severity": 2}
{"drug1": "Droxicam", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with difluprednate.", "severity": 2}
{"drug1": "buspirone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with halcinonide.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "flecainide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with flecainide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with digitoxin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with propoxyphene.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Aliskiren.", "severity": 2}
{"drug1": "Torasemide", "drug2": "metrizamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with metrizamide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Olopatadine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with felbamate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Ciclesonide.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with cyclopentolate.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with tetracaine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with scopolamine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with triprolidine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Empagliflozin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with paroxetine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with clomipramine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with methylphenidate.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with triprolidine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with GUANFACINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "methylergonovine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with methylergonovine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with methylphenidate.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with diltiazem.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with xylometazoline.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Teriflunomide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with GUANFACINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with phenytoin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Methadyl acetate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with glutethimide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with furosemide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with tizanidine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with fluocinonide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with azelastine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Vilanterol.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with OLODATEROL.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diethylstilbestrol is combined with atorvastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with enflurane.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Icatibant.", "severity": 2}
{"drug1": "propranolol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with mecamylamine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "cyclosporin A", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with cyclosporin A.", "severity": 2}
{"drug1": "triazolam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with chlorthalidone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Riociguat.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Tapentadol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Mephobarbital.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Eplerenone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with methazolamide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "ramipril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Bretylium.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with clozapine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with thiothixene.", "severity": 2}
{"drug1": "bromazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with duloxetine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with amcinonide.", "severity": 2}
{"drug1": "meperidine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Thioproperazine.", "severity": 2}
{"drug1": "biperiden", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with morphine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with prazepam.", "severity": 2}
{"drug1": "efavirenz", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with fexofenadine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "metaraminol", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with metaproterenol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Desloratadine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with zafirlukast.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with buprenorphine.", "severity": 2}
{"drug1": "etodolac", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with niflumic acid.", "severity": 2}
{"drug1": "nicergoline", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with vincristine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with nilvadipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with lidocaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with AMILORIDE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with baclofen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with thiopental.", "severity": 2}
{"drug1": "mesalamine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with fludrocortisone.", "severity": 2}
{"drug1": "benztropine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "ketamine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with fexofenadine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with primidone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with bicalutamide.", "severity": 2}
{"drug1": "dapsone", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with Nitroprusside.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "itraconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with flunarizine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Aceprometazine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Agomelatine.", "severity": 2}
{"drug1": "eperisone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Pizotifen.", "severity": 2}
{"drug1": "amobarbital", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with enflurane.", "severity": 2}
{"drug1": "methadone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Mephobarbital.", "severity": 2}
{"drug1": "methadone", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with nalbuphine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with lithium ion.", "severity": 2}
{"drug1": "Articaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with protriptyline.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with fleroxacin.", "severity": 2}
{"drug1": "terbinafine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with isradipine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with dopamine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with protriptyline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with efavirenz.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with primidone.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Amrinone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "enflurane", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Escitalopram.", "severity": 2}
{"drug1": "enflurane", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with decamethonium.", "severity": 2}
{"drug1": "barnidipine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with methyldopa.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with baclofen.", "severity": 2}
{"drug1": "duloxetine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with trifluoperazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with loratadine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with apraclonidine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Telmisartan.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with fludrocortisone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with brotizolam.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with metolazone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Erismodegib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Erismodegib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Pizotifen.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with rasagiline.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with lidocaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with clemastine.", "severity": 2}
{"drug1": "diazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with levodopa.", "severity": 2}
{"drug1": "diazepam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with sevoflurane.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with MOLINDONE.", "severity": 2}
{"drug1": "diazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with GUANFACINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with vigabatrin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with loteprednol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with DEZOCINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with trazodone.", "severity": 2}
{"drug1": "desipramine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with rasagiline.", "severity": 2}
{"drug1": "desipramine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with PROCATEROL.", "severity": 2}
{"drug1": "etodolac", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with nadolol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "meperidine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with butalbital.", "severity": 2}
{"drug1": "buspirone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Fospropofol.", "severity": 2}
{"drug1": "halothane", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with clonidine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with triamcinolone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "halothane", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with propranolol.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Azelnidipine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nelfinavir is combined with Abemaciclib.", "severity": 2}
{"drug1": "clozapine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with tiapride.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Ketobemidone.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with brimonidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Efonidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Flupentixol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with clidinium.", "severity": 2}
{"drug1": "reserpine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with alclofenac.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Pefloxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with estazolam.", "severity": 2}
{"drug1": "barnidipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with triamterene.", "severity": 2}
{"drug1": "tetracaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with fexofenadine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Decitabine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Decitabine is combined with clozapine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with chloral hydrate.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with mesalamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Articaine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with paroxetine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with procaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with trimipramine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Ditazole.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with hydralazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with antipyrine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with butalbital.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Rilpivirine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Rilpivirine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "linezolid", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Cariprazine.", "severity": 2}
{"drug1": "levodopa", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with furazolidone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Fospropofol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with tamoxifen.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambenonium is combined with Varenicline.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Clevidipine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Agomelatine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with losartan.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Tasimelteon.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Sodium oxybate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Sodium oxybate.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with ibuprofen.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "cisplatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with cisplatin.", "severity": 2}
{"drug1": "morphine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Ezetimibe.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with gabapentin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Ropivacaine.", "severity": 2}
{"drug1": "thiopental", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with dantrolene.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with promethazine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Articaine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with topiramate.", "severity": 2}
{"drug1": "quetiapine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with tetracaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Tapentadol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with mecamylamine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with chlorprothixene.", "severity": 2}
{"drug1": "erythromycin", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when erythromycin is combined with sertraline.", "severity": 2}
{"drug1": "thiothixene", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with baclofen.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with ethchlorvynol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with pentazocine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with baclofen.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with levorphanol.", "severity": 2}
{"drug1": "promethazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with vigabatrin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with buspirone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Eplerenone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Etidocaine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Lurasidone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with baclofen.", "severity": 2}
{"drug1": "disulfiram", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when disulfiram is combined with ethanol.", "severity": 2}
{"drug1": "Articaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with zonisamide.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with nabumetone.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with oxycodone.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with ketorolac.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with tenoxicam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Pomalidomide.", "severity": 2}
{"drug1": "imipramine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with clidinium.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with clozapine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with ethosuximide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with amisulpride.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with trichlormethiazide.", "severity": 2}
{"drug1": "quazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with dyclonine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with primidone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Demecarium.", "severity": 2}
{"drug1": "Asenapine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with meclizine.", "severity": 2}
{"drug1": "carprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "furosemide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with hydralazine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with felbamate.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Ramelteon.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with AMILORIDE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Desloratadine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Ketobemidone.", "severity": 2}
{"drug1": "ramipril", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with metoprolol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Levetiracetam.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Olmesartan.", "severity": 2}
{"drug1": "butorphanol", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with glutethimide.", "severity": 2}
{"drug1": "primidone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Difenoxin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with acetazolamide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with benzocaine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "triamterene", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Etidocaine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with clopidogrel.", "severity": 2}
{"drug1": "triamterene", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Metipranolol.", "severity": 2}
{"drug1": "pimozide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Articaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Retigabine.", "severity": 2}
{"drug1": "promazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Articaine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with mirtazapine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with acemetacin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Fospropofol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with vinorelbine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with clozapine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with acetazolamide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Olopatadine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with triamcinolone.", "severity": 2}
{"drug1": "linezolid", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with lithium ion.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with prilocaine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with efavirenz.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with DEZOCINE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with nimodipine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Pipamperone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Articaine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with PENTAERYTHRITOL TETRANITRATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with leflunomide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with flurandrenolide.", "severity": 2}
{"drug1": "pargyline", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with domperidone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Pipotiazine.", "severity": 2}
{"drug1": "buspirone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with maprotiline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Pipotiazine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with pramipexole.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with GUANFACINE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with captopril.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with isoproterenol.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Oxetacaine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with acebutolol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with triamcinolone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Frovatriptan.", "severity": 2}
{"drug1": "bepridil", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with bumetanide.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with clonidine.", "severity": 2}
{"drug1": "bepridil", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with norfloxacin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Melatonin.", "severity": 2}
{"drug1": "tiapride", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Lormetazepam.", "severity": 2}
{"drug1": "Naftifine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "butorphanol", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with pargyline.", "severity": 2}
{"drug1": "buspirone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with mesoridazine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Pipotiazine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with chlorthalidone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with clonazepam.", "severity": 2}
{"drug1": "diflorasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "suprofen", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with nimesulide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with clidinium.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Pipamperone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with fenbufen.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Pralatrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Pralatrexate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with tiapride.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with ketoprofen.", "severity": 2}
{"drug1": "alprazolam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with vigabatrin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with scopolamine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Mometasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with fleroxacin.", "severity": 2}
{"drug1": "promazine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Micafungin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with isradipine.", "severity": 2}
{"drug1": "promazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with baclofen.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Canagliflozin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with fludrocortisone.", "severity": 2}
{"drug1": "azelastine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with triamcinolone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with spironolactone.", "severity": 2}
{"drug1": "aspirin", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "metoprolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with penbutolol.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with DESONIDE.", "severity": 2}
{"drug1": "bepridil", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Carbetocin.", "severity": 2}
{"drug1": "dobutamine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Perospirone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with chloral hydrate.", "severity": 2}
{"drug1": "promazine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with efavirenz.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "promazine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with oxprenolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Fencamfamin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Etidronic acid.", "severity": 2}
{"drug1": "promazine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with prazepam.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with clonazepam.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Aceprometazine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Etidronic acid.", "severity": 2}
{"drug1": "naratriptan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with MOLINDONE.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Pipotiazine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with bepridil.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Melatonin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with cetirizine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with protriptyline.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with tolazoline.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Empagliflozin.", "severity": 2}
{"drug1": "methadone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ethosuximide.", "severity": 2}
{"drug1": "malathion", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when malathion is combined with nicotine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "triazolam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with METAXALONE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with ALFENTANIL.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "halothane", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with doxepin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with fenoprofen.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with sevoflurane.", "severity": 2}
{"drug1": "salicylamide", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "oxazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with prednisone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Cis-mdp.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bendamustine is combined with clozapine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with propoxyphene.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "cytarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with cytarabine.", "severity": 2}
{"drug1": "sotalol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with penbutolol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with selegiline.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with fluoxetine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with duloxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with meclizine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with tiagabine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ESMOLOL.", "severity": 2}
{"drug1": "olanzapine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with zonisamide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Desloratadine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with captopril.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with HEROIN.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with acebutolol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Tolcapone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with chloral hydrate.", "severity": 2}
{"drug1": "levorphanol", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with cyclothiazide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Teriflunomide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with flunisolide.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with ropinirole.", "severity": 2}
{"drug1": "reserpine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with doxepin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with triazolam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with dyclonine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with domperidone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with scopolamine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with methyclothiazide.", "severity": 2}
{"drug1": "sulindac", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with oxaprozin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with meclizine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with tetracaine.", "severity": 2}
{"drug1": "losartan", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Salsalate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with nitrazepam.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Empagliflozin.", "severity": 2}
{"drug1": "losartan", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Retigabine.", "severity": 2}
{"drug1": "tiapride", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Desloratadine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Articaine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with clemastine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with paramethasone.", "severity": 2}
{"drug1": "terconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "doxylamine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with sertraline.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with DEZOCINE.", "severity": 2}
{"drug1": "amifostine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with olanzapine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Iloperidone.", "severity": 2}
{"drug1": "loxapine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with dibucaine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Eprosartan.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Levocetirizine.", "severity": 2}
{"drug1": "terconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Tasimelteon.", "severity": 2}
{"drug1": "triazolam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Asenapine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Ethylmorphine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with mecamylamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with papaverine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with pentazocine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with indomethacin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with bromazepam.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with chlorpheniramine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Lurasidone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "meclizine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with flunarizine.", "severity": 2}
{"drug1": "meclizine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with baclofen.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Cis-mdp.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with prazosin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with loratadine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with penbutolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with captopril.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with brotizolam.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with NITROUS ACID.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Ethylmorphine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with desipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Fencamfamin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with imipramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Fencamfamin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with fenbufen.", "severity": 2}
{"drug1": "lidocaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with prazepam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with hydralazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with benazepril.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with clonidine.", "severity": 2}
{"drug1": "labetalol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with floctafenine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with reserpine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with tolmetin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with sertraline.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Phenelzine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Remoxipride.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with isocarboxazid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with aspirin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with tetracaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Retigabine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with lithium ion.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Empagliflozin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with DESONIDE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Hexobarbital.", "severity": 2}
{"drug1": "procyclidine", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with cyclopentolate.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with quinidine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Tolcapone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Salsalate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with etizolam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with equilin.", "severity": 2}
{"drug1": "pargyline", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with dipivefrin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with salicylamide.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with glutethimide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with linezolid.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Pomalidomide.", "severity": 2}
{"drug1": "prednisone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Mometasone.", "severity": 2}
{"drug1": "tirofiban", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with Apixaban.", "severity": 2}
{"drug1": "tolterodine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with propoxyphene.", "severity": 2}
{"drug1": "methoxamine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with nylidrin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Icatibant", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with floctafenine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Fencamfamin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nitroglycerin.", "severity": 2}
{"drug1": "risperidone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with triflupromazine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with brimonidine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Cis-mdp.", "severity": 2}
{"drug1": "Butethal", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Milnacipran.", "severity": 2}
{"drug1": "apomorphine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with selegiline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with meperidine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with chlorpheniramine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with triprolidine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dabigatran etexilate is combined with Deferasirox.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Canagliflozin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with methocarbamol.", "severity": 2}
{"drug1": "benztropine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "HEROIN", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with spironolactone.", "severity": 2}
{"drug1": "pimozide", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with formestane.", "severity": 2}
{"drug1": "selegiline", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with isocarboxazid.", "severity": 2}
{"drug1": "apomorphine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with diltiazem.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Mersalyl.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "amisulpride", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with clomipramine.", "severity": 2}
{"drug1": "temazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with felbamate.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with quinidine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Ramelteon.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with zotepine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with MELPERONE.", "severity": 2}
{"drug1": "timolol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "timolol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with furosemide.", "severity": 2}
{"drug1": "benazepril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with theobromine.", "severity": 2}
{"drug1": "halothane", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Butethal.", "severity": 2}
{"drug1": "halothane", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Hexobarbital.", "severity": 2}
{"drug1": "halothane", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with lithium ion.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "indapamide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Ethylmorphine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with amoxapine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with nortriptyline.", "severity": 2}
{"drug1": "pimozide", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with chloral hydrate.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with vigabatrin.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Propacetamol.", "severity": 2}
{"drug1": "pimozide", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with fludiazepam.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Vilazodone.", "severity": 2}
{"drug1": "Butethal", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Levocetirizine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with nortriptyline.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with amoxapine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with GUANFACINE.", "severity": 2}
{"drug1": "sotalol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with D-mannitol.", "severity": 2}
{"drug1": "triazolam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with proparacaine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "triazolam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Halazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Paliperidone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with paramethasone.", "severity": 2}
{"drug1": "doxepin", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with formoterol.", "severity": 2}
{"drug1": "Icatibant", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with flumethasone.", "severity": 2}
{"drug1": "aspirin", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with niflumic acid.", "severity": 2}
{"drug1": "anagrelide", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with salicylic acid.", "severity": 2}
{"drug1": "flunisolide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Mephobarbital.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with propofol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Ramelteon.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with topiramate.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with mycophenolic acid.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Lorcaserin.", "severity": 2}
{"drug1": "triamterene", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Empagliflozin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Iobenguane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Iobenguane.", "severity": 2}
{"drug1": "Naftifine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with antipyrine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with meperidine.", "severity": 2}
{"drug1": "Trospium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with morphine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with barnidipine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with felbamate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with risperidone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with meclizine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with fenbufen.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Pixantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Pixantrone.", "severity": 2}
{"drug1": "clonazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with promethazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with isoxsuprine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Butethal.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Hexobarbital.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "meperidine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with meclizine.", "severity": 2}
{"drug1": "meperidine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with risperidone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nisoldipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with pancuronium.", "severity": 2}
{"drug1": "scopolamine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with ethotoin.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Vecuronium.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Levetiracetam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with butalbital.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Clobetasone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Halobetasol.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Naftifine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with methocarbamol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with estrone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with triprolidine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with clidinium.", "severity": 2}
{"drug1": "morphine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with quetiapine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Empagliflozin.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloramphenicol is combined with clozapine.", "severity": 2}
{"drug1": "procaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Articaine.", "severity": 2}
{"drug1": "labetalol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with pilocarpine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with dantrolene.", "severity": 2}
{"drug1": "benzocaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with scopolamine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Pipamperone.", "severity": 2}
{"drug1": "estazolam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with mepivacaine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Desloratadine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with carprofen.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with xylometazoline.", "severity": 2}
{"drug1": "butabarbital", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with halothane.", "severity": 2}
{"drug1": "codeine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Etidocaine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Clobetasone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with triamcinolone.", "severity": 2}
{"drug1": "Artemether", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with VERAPAMIL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with D-mannitol.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Melatonin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Metipranolol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with carisoprodol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methotrexate is combined with leflunomide.", "severity": 2}
{"drug1": "proparacaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with MELPERONE.", "severity": 2}
{"drug1": "benazepril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Olopatadine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with promethazine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with clonazepam.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with meclofenamic acid.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Mephobarbital.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with pramipexole.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Teriflunomide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with imipramine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with loratadine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with SERTINDOLE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with VERAPAMIL.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with butamben.", "severity": 2}
{"drug1": "Icatibant", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with zonisamide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with protriptyline.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Tolvaptan.", "severity": 2}
{"drug1": "linezolid", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Ziprasidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with procarbazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Asenapine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Levocetirizine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "ofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with ofloxacin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with meclizine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Butethal.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Iloperidone.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Alitretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when demeclocycline is combined with Alitretinoin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "citric acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with citric acid.", "severity": 2}
{"drug1": "loxapine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Hexobarbital.", "severity": 2}
{"drug1": "nicergoline", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with dihydroergotamine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Lormetazepam.", "severity": 2}
{"drug1": "loxapine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with amobarbital.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Fluprednidene.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with clidinium.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Difenoxin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with formestane.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Bretylium.", "severity": 2}
{"drug1": "doxepin", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Levetiracetam.", "severity": 2}
{"drug1": "maprotiline", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with flunarizine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "trandolapril", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with enalapril.", "severity": 2}
{"drug1": "trandolapril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with diclofenac.", "severity": 2}
{"drug1": "felbamate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with epinephrine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with DESFLURANE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Clobetasone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with acebutolol.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with clomipramine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with mycophenolic acid.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with levorphanol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with dipyridamole.", "severity": 2}
{"drug1": "hydroxyurea", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyurea is combined with leflunomide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with nortriptyline.", "severity": 2}
{"drug1": "clozapine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with amoxapine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with nimodipine.", "severity": 2}
{"drug1": "clozapine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with baclofen.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with sulpiride.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with digoxin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Indacaterol.", "severity": 2}
{"drug1": "clozapine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ESMOLOL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with triprolidine.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ximelagatran is combined with Nintedanib.", "severity": 2}
{"drug1": "pimozide", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with scopolamine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with methocarbamol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "pergolide", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with propofol.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium acetate is combined with Calcifediol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with quinapril.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with cabergoline.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Riociguat is combined with Aliskiren.", "severity": 2}
{"drug1": "doxazosin", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with bumetanide.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with ethosuximide.", "severity": 2}
{"drug1": "ibudilast", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with Olsalazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with butalbital.", "severity": 2}
{"drug1": "terbutaline", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with dopamine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with fluoxetine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with duloxetine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Fencamfamin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with fludiazepam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with chloral hydrate.", "severity": 2}
{"drug1": "isoflurane", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with irbesartan.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "oxazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with clonidine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with triazolam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Flupentixol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Remoxipride.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with reserpine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nisoldipine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with tetracaine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Pomalidomide.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with ZILEUTON.", "severity": 2}
{"drug1": "ramipril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ketoprofen.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with isoxsuprine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with etodolac.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with vigabatrin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Imatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Imatinib.", "severity": 2}
{"drug1": "loratadine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with isocarboxazid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with mefenamic acid.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "clozapine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nitroglycerin.", "severity": 2}
{"drug1": "clozapine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with procaine.", "severity": 2}
{"drug1": "clozapine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with lisinopril.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with nalidixic acid.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with maprotiline.", "severity": 2}
{"drug1": "midazolam", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with nalbuphine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Naftifine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with malathion.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with dobutamine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Cyamemazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with flunarizine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Fluspirilene.", "severity": 2}
{"drug1": "meperidine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Abemaciclib.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with HEROIN.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with DESONIDE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with amitriptyline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Tolcapone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with nortriptyline.", "severity": 2}
{"drug1": "methadone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Levetiracetam.", "severity": 2}
{"drug1": "methadone", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with bromocriptine.", "severity": 2}
{"drug1": "formestane", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with NICORANDIL.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with leflunomide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with mesoridazine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Perospirone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with D-mannitol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with ouabain.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with propoxyphene.", "severity": 2}
{"drug1": "dapsone", "drug2": "mafenide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with mafenide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Aliskiren.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Escitalopram.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with thiamylal.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "quetiapine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with amobarbital.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "benztropine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with HYDROCODONE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with felodipine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with halothane.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Ropivacaine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Levocetirizine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Difenoxin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Pramocaine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Propoxycaine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with meclofenamic acid.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with cilazapril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with thiamylal.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with sulpiride.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with amoxapine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with carisoprodol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with salicylic acid.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with irbesartan.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Difenoxin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Pipotiazine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Pregabalin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with epinephrine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nadolol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Clodronic Acid.", "severity": 2}
{"drug1": "protriptyline", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with sumatriptan.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with prednisone.", "severity": 2}
{"drug1": "Articaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dapagliflozin is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "morphine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with felodipine.", "severity": 2}
{"drug1": "morphine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with nitrous oxide.", "severity": 2}
{"drug1": "reserpine", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with secobarbital.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with topiramate.", "severity": 2}
{"drug1": "thiopental", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Mephobarbital.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Pipamperone.", "severity": 2}
{"drug1": "morphine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with methoxyflurane.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Pizotifen.", "severity": 2}
{"drug1": "buspirone", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with zaleplon.", "severity": 2}
{"drug1": "buspirone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with mepivacaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Desloratadine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with cilazapril.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with duloxetine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with penbutolol.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with fluoxetine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Telmisartan.", "severity": 2}
{"drug1": "salicylamide", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with CLONIXIN.", "severity": 2}
{"drug1": "halothane", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with GUANFACINE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Salsalate", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with alclofenac.", "severity": 2}
{"drug1": "suprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with betamethasone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with prochlorperazine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with nitric oxide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with isradipine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Olopatadine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Pomalidomide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Olmesartan.", "severity": 2}
{"drug1": "clidinium", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Ramelteon.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with maprotiline.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with flunarizine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "zalcitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with zalcitabine.", "severity": 2}
{"drug1": "loxapine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with tranylcypromine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with quetiapine.", "severity": 2}
{"drug1": "clidinium", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with acebutolol.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with nylidrin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Etidocaine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with captopril.", "severity": 2}
{"drug1": "loxapine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with prilocaine.", "severity": 2}
{"drug1": "procaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with lithium ion.", "severity": 2}
{"drug1": "procyclidine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with HEROIN.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Radium-223 chloride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Radium-223 chloride.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Ramelteon.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with quetiapine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with ESMOLOL.", "severity": 2}
{"drug1": "pentazocine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ketamine.", "severity": 2}
{"drug1": "cocaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with linezolid.", "severity": 2}
{"drug1": "nadolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with prednisone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with azelastine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "trazodone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with procaine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Cis-mdp.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with venlafaxine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Remoxipride.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with loxapine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with methocarbamol.", "severity": 2}
{"drug1": "diazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with diflorasone.", "severity": 2}
{"drug1": "morphine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nifedipine.", "severity": 2}
{"drug1": "morphine", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with meprobamate.", "severity": 2}
{"drug1": "morphine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with timolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with sertraline.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "pancuronium", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with isradipine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Olmesartan.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with ketoprofen.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with methyclothiazide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with penbutolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with clozapine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "temozolomide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temozolomide is combined with leflunomide.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with promethazine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with clonazepam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Perospirone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with D-mannitol.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "netilmicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with netilmicin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with flurazepam.", "severity": 2}
{"drug1": "ethotoin", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with venlafaxine.", "severity": 2}
{"drug1": "amifostine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with quetiapine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Pentolinium.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Tramadol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with fexofenadine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with prazosin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with flunitrazepam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with loratadine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Apremilast.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Masoprocol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "quinapril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with floctafenine.", "severity": 2}
{"drug1": "amifostine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with nifedipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with indapamide.", "severity": 2}
{"drug1": "amifostine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with papaverine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with fexofenadine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with CYCLIZINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with moclobemide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with aspirin.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with vinorelbine.", "severity": 2}
{"drug1": "biperiden", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "clozapine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with methoxyflurane.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Levocetirizine.", "severity": 2}
{"drug1": "benztropine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with morphine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Ropivacaine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with atorvastatin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with estrone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with dichlorphenamide.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with venlafaxine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "nabumetone", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Remoxipride.", "severity": 2}
{"drug1": "trazodone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with HEROIN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with mefloquine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "floctafenine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with alclofenac.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Ketobemidone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with felodipine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with glutethimide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with trandolapril.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Methadyl acetate.", "severity": 2}
{"drug1": "diazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Dapagliflozin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Paliperidone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with hydrocortisone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with ZILEUTON.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with etodolac.", "severity": 2}
{"drug1": "tolazoline", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with bumetanide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with efavirenz.", "severity": 2}
{"drug1": "tolazoline", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "sulfanilamide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfanilamide is combined with mecamylamine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with captopril.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with acebutolol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with quetiapine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with maprotiline.", "severity": 2}
{"drug1": "loxapine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Pramocaine.", "severity": 2}
{"drug1": "thiopental", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with methoxyflurane.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with clomipramine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with mecamylamine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with isocarboxazid.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Escitalopram.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with mesoridazine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with quetiapine.", "severity": 2}
{"drug1": "triamterene", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "triamterene", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with felodipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Pinaverium.", "severity": 2}
{"drug1": "triamterene", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with irbesartan.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Bretylium", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with cilazapril.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with nalidixic acid.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with metolazone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Iloperidone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with minoxidil.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with papaverine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with malathion.", "severity": 2}
{"drug1": "lorazepam", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with butorphanol.", "severity": 2}
{"drug1": "ketamine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Nabilone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with metolazone.", "severity": 2}
{"drug1": "tetracaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with sertraline.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Escitalopram.", "severity": 2}
{"drug1": "zonisamide", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with CARTEOLOL.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with gabapentin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Propoxycaine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Pramocaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with ciprofloxacin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Levetiracetam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Erlotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Erlotinib.", "severity": 2}
{"drug1": "indinavir", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indinavir is combined with Abemaciclib.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with fenbufen.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with toremifene.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Flibanserin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Rotigotine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with amoxapine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with lisinopril.", "severity": 2}
{"drug1": "methadone", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with butorphanol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with triflupromazine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lopinavir is combined with Abemaciclib.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Asenapine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with HEROIN.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "losartan", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Varenicline.", "severity": 2}
{"drug1": "loxapine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with brotizolam.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with sevoflurane.", "severity": 2}
{"drug1": "Naftifine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with budesonide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with morphine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Ropivacaine.", "severity": 2}
{"drug1": "carprofen", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with leflunomide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with estazolam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with imipramine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with fludrocortisone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Clobetasone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with dantrolene.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with loratadine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "lorazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with paroxetine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Amrinone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with enalapril.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with maprotiline.", "severity": 2}
{"drug1": "lorazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with flunitrazepam.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with nalbuphine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Ropivacaine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with morphine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with sulfasalazine.", "severity": 2}
{"drug1": "Cladribine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cladribine is combined with clozapine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with butalbital.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Tolvaptan.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ceritinib is combined with Abemaciclib.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Perospirone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with epirizole.", "severity": 2}
{"drug1": "procyclidine", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with propantheline.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Clevidipine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Difenoxin.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with duloxetine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with fluoxetine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with amisulpride.", "severity": 2}
{"drug1": "Mometasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Naftifine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with sulfasalazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Propacetamol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with doxepin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with butamben.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with dichlorphenamide.", "severity": 2}
{"drug1": "itraconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "methysergide", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with isradipine.", "severity": 2}
{"drug1": "suprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with bupropion.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Stepronin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Stepronin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with butalbital.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with brotizolam.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with Trovafloxacin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with halothane.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Delavirdine is combined with atorvastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Tasimelteon.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with terazosin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with timolol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with chlorprothixene.", "severity": 2}
{"drug1": "benazepril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Aceclofenac.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with vinorelbine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Ketobemidone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with clozapine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with decamethonium.", "severity": 2}
{"drug1": "haloperidol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with tiapride.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with hydralazine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with cetirizine.", "severity": 2}
{"drug1": "benazepril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with bumetanide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with protriptyline.", "severity": 2}
{"drug1": "salicylamide", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "promazine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with proparacaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with primidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with desoximetasone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with nitrazepam.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with HEROIN.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with triflupromazine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Clevidipine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with budesonide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with chlorprothixene.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with duloxetine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Teriflunomide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with levodopa.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with topiramate.", "severity": 2}
{"drug1": "isoflurane", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with losartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Fencamfamin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with trazodone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "probenecid", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when probenecid is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with dexamethasone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinblastine is combined with mitomycin C.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with clomipramine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "temazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with clozapine.", "severity": 2}
{"drug1": "zotepine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with flunarizine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with paroxetine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with loratadine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nitrendipine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with flunisolide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Propoxycaine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Pramocaine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with imipramine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nevirapine is combined with atorvastatin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with KETAZOLAM.", "severity": 2}
{"drug1": "codeine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with prazepam.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Difenoxin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ADAPALENE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Iloperidone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with hydralazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Mirabegron.", "severity": 2}
{"drug1": "propofol", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with perphenazine.", "severity": 2}
{"drug1": "codeine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with dyclonine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pitavastatin is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "codeine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with propoxyphene.", "severity": 2}
{"drug1": "amiodarone", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with phentolamine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with furosemide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Paliperidone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "tegafur", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methotrexate is combined with tegafur.", "severity": 2}
{"drug1": "salicylamide", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with fluocinonide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Etidocaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with zonisamide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with cocaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with tiagabine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with ondansetron.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with diflunisal.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with chlormezanone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with chlormezanone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with PAMABROM.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with moclobemide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with phenobarbital.", "severity": 2}
{"drug1": "procaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Echothiophate.", "severity": 2}
{"drug1": "butabarbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with norfloxacin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Remoxipride.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with apraclonidine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Telmisartan.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Pramocaine.", "severity": 2}
{"drug1": "Metixene", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with DEZOCINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with carbamazepine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with methyldopa.", "severity": 2}
{"drug1": "ketamine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Olopatadine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Levocetirizine.", "severity": 2}
{"drug1": "estazolam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "proparacaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Pipamperone.", "severity": 2}
{"drug1": "ramipril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Naftifine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with haloperidol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with manidipine.", "severity": 2}
{"drug1": "imipramine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with dobutamine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with selegiline.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with pancuronium.", "severity": 2}
{"drug1": "isoflurane", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with sevoflurane.", "severity": 2}
{"drug1": "isoflurane", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with chlorprothixene.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Masoprocol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with D-mannitol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with protriptyline.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with lisinopril.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with metolazone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with nitroglycerin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with cetirizine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with SUFENTANIL.", "severity": 2}
{"drug1": "lorazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with sulfasalazine.", "severity": 2}
{"drug1": "timolol", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with nisoldipine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with topiramate.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with zotepine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "quinidine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Ketobemidone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with venlafaxine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with clemastine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Pipotiazine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with propoxyphene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with dyclonine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with metoclopramide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with mesalamine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with amcinonide.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Aripiprazole.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with chlorprothixene.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Aceprometazine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with prednisone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with sevoflurane.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with estrone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with MOLINDONE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with tolmetin.", "severity": 2}
{"drug1": "epirizole", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "bepridil", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with lovastatin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with medrysone.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Iloperidone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with nicotine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Cevimeline.", "severity": 2}
{"drug1": "halothane", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Eplerenone.", "severity": 2}
{"drug1": "imipramine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with dipyridamole.", "severity": 2}
{"drug1": "halothane", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with methazolamide.", "severity": 2}
{"drug1": "ramipril", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with betaxolol.", "severity": 2}
{"drug1": "halothane", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with felbamate.", "severity": 2}
{"drug1": "floctafenine", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with mycophenolic acid.", "severity": 2}
{"drug1": "citalopram", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Fluspirilene.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with tiapride.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Ziprasidone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with clidinium.", "severity": 2}
{"drug1": "etodolac", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with betamethasone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Etidronic acid.", "severity": 2}
{"drug1": "minoxidil", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with GUANFACINE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Iloperidone.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Escitalopram.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with flunitrazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with methoxyflurane.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Linagliptin.", "severity": 2}
{"drug1": "epirizole", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Propacetamol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with trichlormethiazide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Halazepam.", "severity": 2}
{"drug1": "antipyrine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with alclometasone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with proparacaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with methyclothiazide.", "severity": 2}
{"drug1": "barnidipine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with trandolapril.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with nimodipine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with selegiline.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with MOXONIDINE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "butabarbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with fexofenadine.", "severity": 2}
{"drug1": "miconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with thiamylal.", "severity": 2}
{"drug1": "dyclonine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with desipramine.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with dipyridamole.", "severity": 2}
{"drug1": "Normethadone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with zonisamide.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Ditazole.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with losartan.", "severity": 2}
{"drug1": "Normethadone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with tiagabine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "halothane", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Levocetirizine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with budesonide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with tretinoin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Lurasidone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with ergocalciferol.", "severity": 2}
{"drug1": "benazepril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Propoxycaine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with sotalol.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with topiramate.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolpidem is combined with Escitalopram.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with trandolapril.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Ziprasidone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with clemastine.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when erythromycin is combined with Flibanserin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with ibuprofen.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with clonidine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with bromazepam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with tiapride.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with morphine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with papaverine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with formoterol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Lornoxicam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with isoetharine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with amobarbital.", "severity": 2}
{"drug1": "floxuridine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floxuridine is combined with leflunomide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Levomilnacipran.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with etodolac.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Iloperidone.", "severity": 2}
{"drug1": "morphine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with isoxsuprine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with dipyridamole.", "severity": 2}
{"drug1": "Tramadol", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with risperidone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with hydrocortisone.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with ZILEUTON.", "severity": 2}
{"drug1": "Tramadol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with meclizine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with diltiazem.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Agomelatine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with flunarizine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with bromocriptine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Aceprometazine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with dantrolene.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Butethal", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Normethadone.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with metformin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with terazosin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with alclometasone.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Pinaverium.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Butethal.", "severity": 2}
{"drug1": "oxazepam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with amobarbital.", "severity": 2}
{"drug1": "lorazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with desipramine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Olopatadine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Iloperidone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with haloperidol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with clidinium.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Fluspirilene.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with triflupromazine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Clevidipine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with nimesulide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Artemether", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with dapsone.", "severity": 2}
{"drug1": "clidinium", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "aspirin", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with HEROIN.", "severity": 2}
{"drug1": "procyclidine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with oxycodone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Oxetacaine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with pancuronium.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Cyamemazine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiopental", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with brotizolam.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Levocetirizine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with methyldopa.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Telmisartan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with apraclonidine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Estrone sulfate.", "severity": 2}
{"drug1": "captopril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with oxaprozin.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "Trospium", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Atracurium besylate.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with topiramate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Fluspirilene.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with amisulpride.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Ketobemidone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Tixocortol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Olopatadine.", "severity": 2}
{"drug1": "clozapine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with carvedilol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with betamethasone.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Ketobemidone.", "severity": 2}
{"drug1": "prazosin", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Eprosartan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Tramadol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with promethazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Methadyl acetate.", "severity": 2}
{"drug1": "epirizole", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "triamterene", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Telmisartan.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Desloratadine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with meclizine.", "severity": 2}
{"drug1": "methadone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with scopolamine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Nepafenac.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with zonisamide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with tubocurarine.", "severity": 2}
{"drug1": "pergolide", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with doxorubicin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with benazepril.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with VERAPAMIL.", "severity": 2}
{"drug1": "butamben", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with maprotiline.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with simvastatin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "methazolamide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with hydralazine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with methacholine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with methazolamide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Eplerenone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with pargyline.", "severity": 2}
{"drug1": "Halazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with glutethimide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with trifluoperazine.", "severity": 2}
{"drug1": "testosterone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone is combined with atorvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ketamine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with methazolamide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when STIRIPENTOL is combined with Milnacipran.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "probenecid", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when probenecid is combined with furosemide.", "severity": 2}
{"drug1": "selegiline", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with mirtazapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with timolol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with DESFLURANE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Flupentixol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with lisinopril.", "severity": 2}
{"drug1": "pergolide", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with epinephrine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with fexofenadine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "temazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "temazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with dyclonine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with acetaminophen.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Pipotiazine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with thiothixene.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Thioproperazine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with methyclothiazide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with diflorasone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with duloxetine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Estrone sulfate.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with fluoxetine.", "severity": 2}
{"drug1": "quazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with meclizine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Deferasirox.", "severity": 2}
{"drug1": "topiramate", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with primidone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Levetiracetam.", "severity": 2}
{"drug1": "nabumetone", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with oxaprozin.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with meperidine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with alclofenac.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with BISOPROLOL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Telmisartan.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with phenytoin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with apraclonidine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "enflurane", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with SERTINDOLE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Etomidate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Escitalopram.", "severity": 2}
{"drug1": "clomipramine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with OLODATEROL.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with carvedilol.", "severity": 2}
{"drug1": "selegiline", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with AMILORIDE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with flunitrazepam.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with primidone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Retigabine.", "severity": 2}
{"drug1": "methadone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Difenoxin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with ketamine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with MELPERONE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with alclofenac.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Nabilone.", "severity": 2}
{"drug1": "codeine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with hydromorphone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Eplerenone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with methazolamide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with brimonidine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Iloperidone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Articaine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Uramustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Uramustine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with thalidomide.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with leflunomide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Etoricoxib.", "severity": 2}
{"drug1": "methadone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with tetracaine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with dobutamine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with protriptyline.", "severity": 2}
{"drug1": "tolmetin", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with niflumic acid.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with mequitazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with butalbital.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with tizanidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with furosemide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Icatibant.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with oxycodone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with buspirone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with enoxacin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Normethadone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Tolcapone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with amitriptyline.", "severity": 2}
{"drug1": "carprofen", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with niflumic acid.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Tapentadol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Sacubitril.", "severity": 2}
{"drug1": "methadone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with trifluoperazine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with amcinonide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "methadone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with amisulpride.", "severity": 2}
{"drug1": "diflunisal", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with lisinopril.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Pipamperone.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Panobinostat is combined with leflunomide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nitroglycerin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with furosemide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with tizanidine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with phentolamine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when simvastatin is combined with atorvastatin.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Sacubitril.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Fesoterodine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Olopatadine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with amisulpride.", "severity": 2}
{"drug1": "oxazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "cocaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with tizanidine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with ritodrine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Difenoxin.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with PROCATEROL.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Tasimelteon.", "severity": 2}
{"drug1": "mefloquine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with atorvastatin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Aceprometazine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Zoledronic acid.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with meperidine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with isradipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "enflurane", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with doxepin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with indapamide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with loratadine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with prazosin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with citalopram.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with imipramine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lomitapide is combined with atorvastatin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "methysergide", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with topotecan.", "severity": 2}
{"drug1": "quazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "quazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Triflusal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Triflusal.", "severity": 2}
{"drug1": "indomethacin", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with medrysone.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Ticagrelor.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with methylene blue.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with thiamylal.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with clomiphene.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with oxprenolol.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with codeine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with meperidine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with butalbital.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with prazepam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with halothane.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Mometasone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with metoclopramide.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Eplerenone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Pizotifen.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with methazolamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Levobupivacaine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with nifedipine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Levocetirizine.", "severity": 2}
{"drug1": "linezolid", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with naratriptan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with carvedilol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with papaverine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with GUANFACINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Desloratadine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with trimipramine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with DEZOCINE.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Propacetamol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with fenoprofen.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with salicylamide.", "severity": 2}
{"drug1": "felodipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with nifedipine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Mometasone.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with propoxyphene.", "severity": 2}
{"drug1": "trimipramine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with promethazine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with topotecan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Fencamfamin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Elbasvir.", "severity": 2}
{"drug1": "clidinium", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with chlorpheniramine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with methyclothiazide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Thioproperazine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Etoricoxib.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with quetiapine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with DESFLURANE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with etoposide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with triamcinolone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with clonazepam.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Pipotiazine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Frovatriptan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with linezolid.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Pipotiazine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with Enalaprilat.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with methscopolamine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "butamben", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "zaleplon", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with estazolam.", "severity": 2}
{"drug1": "thiamylal", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Difenoxin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Pipotiazine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with ADAPALENE.", "severity": 2}
{"drug1": "Butethal", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Levetiracetam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Normethadone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with budesonide.", "severity": 2}
{"drug1": "butamben", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with methocarbamol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with Empagliflozin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Melatonin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with pimozide.", "severity": 2}
{"drug1": "tolazoline", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with ESMOLOL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with zotepine.", "severity": 2}
{"drug1": "furosemide", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with chloral hydrate.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Potassium citrate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Lormetazepam.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RUCAPARIB is combined with oxycodone.", "severity": 2}
{"drug1": "propofol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with papaverine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with irbesartan.", "severity": 2}
{"drug1": "resveratrol", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with formestane.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with alclometasone.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Escitalopram.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with terbutaline.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with alclofenac.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with levodopa.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with quetiapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Normethadone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with butamben.", "severity": 2}
{"drug1": "thiothixene", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with tizanidine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PHENPROCOUMON is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "triamterene", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with haloperidol.", "severity": 2}
{"drug1": "codeine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Pipamperone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with zotepine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with MELPERONE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with ramipril.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nilotinib is combined with oxycodone.", "severity": 2}
{"drug1": "tiapride", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with vigabatrin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with valsartan.", "severity": 2}
{"drug1": "Normethadone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with dantrolene.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Spectinomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Spectinomycin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with pimozide.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Articaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Olopatadine.", "severity": 2}
{"drug1": "aspirin", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with antipyrine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with tiapride.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with acebutolol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Retigabine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with captopril.", "severity": 2}
{"drug1": "tolmetin", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with zaltoprofen.", "severity": 2}
{"drug1": "indomethacin", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with flurandrenolide.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "ceftriaxone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with ceftriaxone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Deferasirox.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with NITROUS ACID.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with nitrous oxide.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Lurasidone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with cetirizine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with protriptyline.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with captopril.", "severity": 2}
{"drug1": "lidocaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with chlormezanone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nitrous oxide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with hydromorphone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with triamterene.", "severity": 2}
{"drug1": "enalapril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with fenoprofen.", "severity": 2}
{"drug1": "reserpine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with meclizine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with furosemide.", "severity": 2}
{"drug1": "reserpine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with tiapride.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with phentolamine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfaphenazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfaphenazole.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Etidocaine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with Isoflurophate.", "severity": 2}
{"drug1": "procyclidine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "imipramine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with chlorthalidone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with nimesulide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with dorzolamide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Levetiracetam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with dibucaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with homoharringtonine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with DEZOCINE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with butamben.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with amcinonide.", "severity": 2}
{"drug1": "propofol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with codeine.", "severity": 2}
{"drug1": "reserpine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with bromazepam.", "severity": 2}
{"drug1": "propofol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Metipranolol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with triazolam.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rivaroxaban is combined with meperidine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with etizolam.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "enalapril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with CLONIXIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glyburide is combined with Carbocisteine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with CARTEOLOL.", "severity": 2}
{"drug1": "enalapril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Droxicam.", "severity": 2}
{"drug1": "enalapril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Pipamperone.", "severity": 2}
{"drug1": "enalapril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Loxoprofen.", "severity": 2}
{"drug1": "propantheline", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Perospirone.", "severity": 2}
{"drug1": "losartan", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with carprofen.", "severity": 2}
{"drug1": "lisinopril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with dipyridamole.", "severity": 2}
{"drug1": "midazolam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with MELPERONE.", "severity": 2}
{"drug1": "aspirin", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with etodolac.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "aspirin", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with hydrocortisone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with maprotiline.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with mesoridazine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with DESONIDE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Asenapine.", "severity": 2}
{"drug1": "buspirone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with brotizolam.", "severity": 2}
{"drug1": "buspirone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with etizolam.", "severity": 2}
{"drug1": "bepridil", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with thalidomide.", "severity": 2}
{"drug1": "temazepam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "acemetacin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with acebutolol.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfinpyrazone is combined with atorvastatin.", "severity": 2}
{"drug1": "carboprost trometamol", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboprost trometamol is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with meclofenamic acid.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with cabergoline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with isoxsuprine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Gefitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Gefitinib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with clozapine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Lumiracoxib.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Mometasone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with ethosuximide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Desloratadine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with felbamate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with minoxidil.", "severity": 2}
{"drug1": "indapamide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with mecamylamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "metaraminol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with metaraminol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with dantrolene.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Pinaverium.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with clonazepam.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Levocetirizine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with oxymorphone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with PERHEXILINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with fludiazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Normethadone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with clorazepate.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with pimozide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with triamcinolone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Difenoxin.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Lercanidipine.", "severity": 2}
{"drug1": "loxapine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with clidinium.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Dapagliflozin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Pregabalin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with pimozide.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Lurasidone.", "severity": 2}
{"drug1": "naratriptan", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with sertraline.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Fluspirilene.", "severity": 2}
{"drug1": "metoprolol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with captopril.", "severity": 2}
{"drug1": "valsartan", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with losartan.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with sulfasalazine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Etoricoxib.", "severity": 2}
{"drug1": "oxazepam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "losartan", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with ramipril.", "severity": 2}
{"drug1": "losartan", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Masoprocol.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with clonidine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with tolfenamic acid.", "severity": 2}
{"drug1": "loxapine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Pomalidomide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "pargyline", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Vilanterol.", "severity": 2}
{"drug1": "fenbufen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with hydralazine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with fexofenadine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Bretylium.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ketamine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Milnacipran.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with rasagiline.", "severity": 2}
{"drug1": "clonidine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "codeine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Fluspirilene.", "severity": 2}
{"drug1": "codeine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with flunarizine.", "severity": 2}
{"drug1": "halothane", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with mefloquine.", "severity": 2}
{"drug1": "codeine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with METAXALONE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with trimipramine.", "severity": 2}
{"drug1": "triazolam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Butethal", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with maprotiline.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Lurasidone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with ethosuximide.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with nitrendipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with lithium ion.", "severity": 2}
{"drug1": "citalopram", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Thioproperazine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Iloperidone.", "severity": 2}
{"drug1": "papaverine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Riociguat.", "severity": 2}
{"drug1": "loxapine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with nitrous oxide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "risperidone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Levocetirizine.", "severity": 2}
{"drug1": "sotalol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with captopril.", "severity": 2}
{"drug1": "pentazocine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Aliskiren.", "severity": 2}
{"drug1": "azelastine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with alclometasone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with indapamide.", "severity": 2}
{"drug1": "azelastine", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with mesalamine.", "severity": 2}
{"drug1": "BENZOYL PEROXIDE", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZOYL PEROXIDE is combined with dapsone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ritodrine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with fenoldopam.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with SUFENTANIL.", "severity": 2}
{"drug1": "lidocaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with scopolamine.", "severity": 2}
{"drug1": "pimozide", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with brotizolam.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Demecarium.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Desloratadine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Quinine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Quinine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with desipramine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with flunarizine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with diflorasone.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Ciclesonide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with chlorthalidone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with thiamylal.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with desipramine.", "severity": 2}
{"drug1": "promethazine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with naratriptan.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with rizatriptan.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with halothane.", "severity": 2}
{"drug1": "risperidone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with thiothixene.", "severity": 2}
{"drug1": "methazolamide", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with phenytoin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with ambenonium.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Perospirone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Retigabine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with methyldopa.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Telmisartan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Desloratadine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with apraclonidine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with mepivacaine.", "severity": 2}
{"drug1": "desipramine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with ritodrine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "bumetanide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with nadolol.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Normethadone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Articaine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Iloperidone.", "severity": 2}
{"drug1": "prazosin", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "prazosin", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Metipranolol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Remoxipride.", "severity": 2}
{"drug1": "moclobemide", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with loxapine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with oxaprozin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with fexofenadine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Difenoxin.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with nitrendipine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with tolmetin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with ibuprofen.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with promazine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with minoxidil.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Normethadone.", "severity": 2}
{"drug1": "clozapine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with propranolol.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with CLONIXIN.", "severity": 2}
{"drug1": "Butethal", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with amoxapine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with selegiline.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with D-mannitol.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Droxicam.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Loxoprofen.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Retigabine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Levomepromazine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with clenbuterol.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with baclofen.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Ketobemidone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with METAXALONE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with carbamazepine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with tiagabine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with vinorelbine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Tasimelteon.", "severity": 2}
{"drug1": "doxepin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Flibanserin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with fludiazepam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with chloral hydrate.", "severity": 2}
{"drug1": "estazolam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with bupivacaine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Ropivacaine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "estazolam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Etomidate.", "severity": 2}
{"drug1": "clonidine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Pomalidomide.", "severity": 2}
{"drug1": "timolol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with papaverine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with mecamylamine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with budesonide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "promethazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with olanzapine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Iloperidone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with CLONIXIN.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Difenoxin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Cyamemazine.", "severity": 2}
{"drug1": "nystatin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with nisoldipine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with diltiazem.", "severity": 2}
{"drug1": "propofol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with acebutolol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with felodipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Loxoprofen.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Droxicam.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with tolfenamic acid.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with amoxapine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with mycophenolic acid.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with nortriptyline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with felodipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Nepafenac.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcifediol is combined with Calcipotriol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "felbamate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Retigabine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with hydromorphone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Pipamperone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Teriflunomide.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when edrophonium is combined with Carbamylcholine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with paroxetine.", "severity": 2}
{"drug1": "loxapine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with fexofenadine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with propofol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with acetazolamide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Levobupivacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with bromazepam.", "severity": 2}
{"drug1": "barnidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Aliskiren.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with methyldopa.", "severity": 2}
{"drug1": "propofol", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Desloratadine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with apraclonidine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with zaleplon.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with mepivacaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with paroxetine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with chlormezanone.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with oxycodone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with doxepin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with promethazine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with diflunisal.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with CYCLIZINE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Escitalopram.", "severity": 2}
{"drug1": "perphenazine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with trazodone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Phenelzine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Empagliflozin.", "severity": 2}
{"drug1": "etodolac", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with salicylamide.", "severity": 2}
{"drug1": "Retigabine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with nefazodone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with enalapril.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "reserpine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with midazolam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with butamben.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Lornoxicam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with triamcinolone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with isoxsuprine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Levobupivacaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Normethadone.", "severity": 2}
{"drug1": "temazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with furosemide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with timolol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Estrone sulfate.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Tasimelteon.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Torasemide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with duloxetine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with phenytoin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with fluoxetine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with halothane.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with desoximetasone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "diazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Olopatadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with desipramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Nebivolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Clevidipine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with lidocaine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with tenoxicam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with chloral hydrate.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Conivaptan.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with fleroxacin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with nabumetone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Lurasidone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with atorvastatin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ketorolac.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with dantrolene.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with nitroglycerin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with trandolapril.", "severity": 2}
{"drug1": "benzocaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with topiramate.", "severity": 2}
{"drug1": "ipratropium", "drug2": "procyclidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with procyclidine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Agomelatine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with lisinopril.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with quinapril.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Canagliflozin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with clomipramine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with HEROIN.", "severity": 2}
{"drug1": "timolol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with nitroglycerin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with thiothixene.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with amitriptyline.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with reserpine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Tolcapone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with galanthamine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with brotizolam.", "severity": 2}
{"drug1": "carprofen", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Arformoterol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Pizotifen.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with bromazepam.", "severity": 2}
{"drug1": "gabapentin", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with chlorzoxazone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Flibanserin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with chloroquine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Deferasirox.", "severity": 2}
{"drug1": "benzocaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with baclofen.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Canagliflozin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with minoxidil.", "severity": 2}
{"drug1": "barnidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with tenoxicam.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Etidronic acid.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "meperidine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with ketorolac.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with trandolapril.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Flupentixol.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with nabumetone.", "severity": 2}
{"drug1": "enflurane", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with butamben.", "severity": 2}
{"drug1": "minoxidil", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with diltiazem.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Remoxipride.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Deferasirox.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Levalbuterol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with chloral hydrate.", "severity": 2}
{"drug1": "isradipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "chloroquine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with alclofenac.", "severity": 2}
{"drug1": "suprofen", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Icatibant.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with topiramate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with fluocinonide.", "severity": 2}
{"drug1": "quinidine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "mifepristone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with mifepristone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with gabapentin.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with arsenic trioxide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with fludiazepam.", "severity": 2}
{"drug1": "clozapine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with methyldopa.", "severity": 2}
{"drug1": "clozapine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Telmisartan.", "severity": 2}
{"drug1": "clozapine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Desloratadine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with cilostazol.", "severity": 2}
{"drug1": "clozapine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with zaleplon.", "severity": 2}
{"drug1": "clozapine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with mepivacaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Agomelatine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with salicylamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with thiopental.", "severity": 2}
{"drug1": "cetirizine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with sertraline.", "severity": 2}
{"drug1": "salicylamide", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "lidocaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with tetracaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with triflupromazine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with oxprenolol.", "severity": 2}
{"drug1": "butamben", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with citalopram.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sorafenib is combined with clozapine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Lumiracoxib.", "severity": 2}
{"drug1": "benzocaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "benzocaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with prazepam.", "severity": 2}
{"drug1": "Halazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "ioversol", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ioversol is combined with metformin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Lormetazepam.", "severity": 2}
{"drug1": "Halazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with maprotiline.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "procaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with flunitrazepam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with lithium ion.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Hexobarbital.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Butethal.", "severity": 2}
{"drug1": "pentazocine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with amobarbital.", "severity": 2}
{"drug1": "butabarbital", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with DESFLURANE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with duloxetine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with fluoxetine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "propofol", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Lurasidone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with chlorothiazide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with bumetanide.", "severity": 2}
{"drug1": "primidone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with levodopa.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with apraclonidine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with fexofenadine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with rabeprazole.", "severity": 2}
{"drug1": "isradipine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with losartan.", "severity": 2}
{"drug1": "morphine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with meperidine.", "severity": 2}
{"drug1": "temazepam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "morphine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with prazosin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Perospirone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Olopatadine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Pizotifen.", "severity": 2}
{"drug1": "olanzapine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Propacetamol.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with tiagabine.", "severity": 2}
{"drug1": "methysergide", "drug2": "colchicine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with colchicine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with timolol.", "severity": 2}
{"drug1": "linezolid", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with periciazine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with zonisamide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "butabarbital", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with HEROIN.", "severity": 2}
{"drug1": "tolmetin", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with amcinonide.", "severity": 2}
{"drug1": "halothane", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Lofexidine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with edrophonium.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with droxidopa.", "severity": 2}
{"drug1": "morphine", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Alvimopan.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with GUANFACINE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "docetaxel", "drug2": "goserelin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with goserelin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Pizotifen.", "severity": 2}
{"drug1": "gabapentin", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with quazepam.", "severity": 2}
{"drug1": "gabapentin", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with prazepam.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Difenoxin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with KETAZOLAM.", "severity": 2}
{"drug1": "nimesulide", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with fludrocortisone.", "severity": 2}
{"drug1": "miconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with flunarizine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Paliperidone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with isoxsuprine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Etomidate.", "severity": 2}
{"drug1": "meprobamate", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with bupivacaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Ropivacaine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with metoclopramide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Retigabine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Mometasone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with terazosin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with trimipramine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "quazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with felbamate.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with aspirin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with nitric oxide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with ESMOLOL.", "severity": 2}
{"drug1": "topiramate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with dantrolene.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with nalbuphine.", "severity": 2}
{"drug1": "epirizole", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "epirizole", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with AMILORIDE.", "severity": 2}
{"drug1": "milrinone", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with diflunisal.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "suprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Droxicam.", "severity": 2}
{"drug1": "suprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with fosinopril.", "severity": 2}
{"drug1": "suprofen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Loxoprofen.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Desloratadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with dopamine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with isocarboxazid.", "severity": 2}
{"drug1": "suprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with clomipramine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Milnacipran.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with physostigmine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with tretinoin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ethotoin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with fexofenadine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with naratriptan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with rizatriptan.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with haloperidol.", "severity": 2}
{"drug1": "morphine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with doxepin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "enalapril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with nadolol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Empagliflozin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Lurasidone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Bretylium.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Enalaprilat.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Fesoterodine.", "severity": 2}
{"drug1": "promazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with tetracaine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with sumatriptan.", "severity": 2}
{"drug1": "doxepin", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with periciazine.", "severity": 2}
{"drug1": "clozapine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with gabapentin.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Olsalazine.", "severity": 2}
{"drug1": "bepridil", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with nadolol.", "severity": 2}
{"drug1": "bepridil", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with bromocriptine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Tapentadol.", "severity": 2}
{"drug1": "estrone", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Ospemifene.", "severity": 2}
{"drug1": "buspirone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "biperiden", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "buspirone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with baclofen.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with primidone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with nitrous oxide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Almotriptan.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Tolcapone.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with amitriptyline.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with PAMABROM.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with SERATRODAST.", "severity": 2}
{"drug1": "propofol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Pipamperone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Flupentixol.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with rasagiline.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ethosuximide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with dexamethasone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with olanzapine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "halothane", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "butorphanol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with clonidine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with methylprednisolone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxorubicin is combined with clozapine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Tolvaptan.", "severity": 2}
{"drug1": "mesalamine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with tolterodine.", "severity": 2}
{"drug1": "thiopental", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with loratadine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with chlorprothixene.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Fencamfamin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Articaine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Aliskiren.", "severity": 2}
{"drug1": "sulindac", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Lornoxicam.", "severity": 2}
{"drug1": "Artemether", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with tolfenamic acid.", "severity": 2}
{"drug1": "trandolapril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with acebutolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Remoxipride.", "severity": 2}
{"drug1": "fosinopril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with felodipine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with nimesulide.", "severity": 2}
{"drug1": "clonidine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with cilazapril.", "severity": 2}
{"drug1": "trandolapril", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with captopril.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Clobetasone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with enalapril.", "severity": 2}
{"drug1": "labetalol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with DESONIDE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with dobutamine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with Carbamylcholine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with loratadine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with nicotinamide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "PHENYLACETIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with PHENYLACETIC ACID.", "severity": 2}
{"drug1": "floctafenine", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with carprofen.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with PAMABROM.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with diphenhydramine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with fenbufen.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with methyldopa.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with tiapride.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyzine is combined with nefazodone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Deferasirox.", "severity": 2}
{"drug1": "risperidone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Pomalidomide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with desoximetasone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with tetracaine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Telmisartan.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with alclofenac.", "severity": 2}
{"drug1": "Bretylium", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "zotepine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Etidocaine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with salicylamide.", "severity": 2}
{"drug1": "hexetidine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with nisoldipine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with hydrocortisone.", "severity": 2}
{"drug1": "clidinium", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with duloxetine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with tetracaine.", "severity": 2}
{"drug1": "clidinium", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with fluoxetine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Ramelteon.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with acebutolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with midazolam.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with dantrolene.", "severity": 2}
{"drug1": "diclofenac", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with salicylamide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with amoxapine.", "severity": 2}
{"drug1": "butalbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Gallium nitrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Gallium nitrate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "suprofen", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "methysergide", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with lomustine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with donepezil.", "severity": 2}
{"drug1": "methysergide", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with mitoxantrone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with flurandrenolide.", "severity": 2}
{"drug1": "methysergide", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with bromocriptine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with cetirizine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with etizolam.", "severity": 2}
{"drug1": "primidone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Desloratadine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with scopolamine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with manidipine.", "severity": 2}
{"drug1": "Butethal", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with tiapride.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "triazolam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Etidocaine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Azelnidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with azelastine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Efonidipine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Lacidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with captopril.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ramipril.", "severity": 2}
{"drug1": "morphine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with oxymorphone.", "severity": 2}
{"drug1": "morphine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with acebutolol.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with valsartan.", "severity": 2}
{"drug1": "morphine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with zopiclone.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Droxicam.", "severity": 2}
{"drug1": "imipramine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with phentolamine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Loxoprofen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Propacetamol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with CLONIXIN.", "severity": 2}
{"drug1": "pimozide", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Ethylmorphine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Sitaxsentan.", "severity": 2}
{"drug1": "morphine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Pomalidomide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with donepezil.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with astemizole.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with prednisone.", "severity": 2}
{"drug1": "ethotoin", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with clomipramine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Teriflunomide.", "severity": 2}
{"drug1": "morphine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with terazosin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Normethadone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with DESFLURANE.", "severity": 2}
{"drug1": "risperidone", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with levorphanol.", "severity": 2}
{"drug1": "risperidone", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with perphenazine.", "severity": 2}
{"drug1": "tiapride", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with phenytoin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with alclofenac.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with meclizine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with metoclopramide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Tasimelteon.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with metaproterenol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with clozapine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with haloperidol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with rivastigmine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with propofol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with levodopa.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Halobetasol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with paramethasone.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with primidone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with etizolam.", "severity": 2}
{"drug1": "risperidone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Paliperidone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with meclofenamic acid.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with salicylic acid.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with quetiapine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with mefloquine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with dipyridamole.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with buspirone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with metaproterenol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with efavirenz.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Butethal", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Methadyl acetate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with brotizolam.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with bepridil.", "severity": 2}
{"drug1": "prazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "Butethal", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with glutethimide.", "severity": 2}
{"drug1": "raloxifene", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when raloxifene is combined with atorvastatin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with tranylcypromine.", "severity": 2}
{"drug1": "prednisone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with sparfloxacin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "trazodone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with cetirizine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with benzocaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with vigabatrin.", "severity": 2}
{"drug1": "trazodone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with protriptyline.", "severity": 2}
{"drug1": "imipramine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nitric oxide.", "severity": 2}
{"drug1": "imipramine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with Pefloxacin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with tizanidine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with amitriptyline.", "severity": 2}
{"drug1": "cocaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with felbamate.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Tolcapone.", "severity": 2}
{"drug1": "labetalol", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with terbutaline.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Pipamperone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with oxymorphone.", "severity": 2}
{"drug1": "labetalol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Eprosartan.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Tixocortol.", "severity": 2}
{"drug1": "pramipexole", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with valsartan.", "severity": 2}
{"drug1": "procaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with loratadine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Halobetasol.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Tasimelteon.", "severity": 2}
{"drug1": "meperidine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Etidocaine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with GUANFACINE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with efavirenz.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Drospirenone.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Milnacipran.", "severity": 2}
{"drug1": "oxycodone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with triamterene.", "severity": 2}
{"drug1": "propofol", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with timolol.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Salbutamol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with doxepin.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with nalbuphine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Iloperidone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with flunisolide.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with codeine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with nefazodone.", "severity": 2}
{"drug1": "propofol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with fosinopril.", "severity": 2}
{"drug1": "trazodone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Normethadone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with SERATRODAST.", "severity": 2}
{"drug1": "propofol", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with methoxyflurane.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with mepivacaine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Desloratadine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with lovastatin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Droxicam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Agomelatine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Melatonin.", "severity": 2}
{"drug1": "Carfilzomib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carfilzomib is combined with clozapine.", "severity": 2}
{"drug1": "clonidine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with clonazepam.", "severity": 2}
{"drug1": "risperidone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with promethazine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with quetiapine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Fospropofol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Levocetirizine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Pomalidomide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Lormetazepam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Desloratadine.", "severity": 2}
{"drug1": "etizolam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with dantrolene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with zaleplon.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Mometasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with propoxyphene.", "severity": 2}
{"drug1": "dyclonine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with clidinium.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Lornoxicam.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "zalcitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with zalcitabine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with maprotiline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Aceclofenac.", "severity": 2}
{"drug1": "Etomidate", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with mesoridazine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with sertraline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with zaltoprofen.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with butalbital.", "severity": 2}
{"drug1": "trimipramine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with clenbuterol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with valsartan.", "severity": 2}
{"drug1": "propofol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with fexofenadine.", "severity": 2}
{"drug1": "Butethal", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with fluoxetine.", "severity": 2}
{"drug1": "Artemether", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with bepridil.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Butethal", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with duloxetine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with amoxapine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Amrinone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Ketobemidone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with moclobemide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with methylprednisolone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Deferasirox.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with nimesulide.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with fosinopril.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with prazepam.", "severity": 2}
{"drug1": "nimodipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with dipyridamole.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with KETAZOLAM.", "severity": 2}
{"drug1": "cabergoline", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with METAXALONE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with prednisone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Isoflurophate.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Mometasone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with sulpiride.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Ramelteon.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apixaban is combined with Nintedanib.", "severity": 2}
{"drug1": "sertraline", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with sulpiride.", "severity": 2}
{"drug1": "isoflurane", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with propranolol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Nebivolol.", "severity": 2}
{"drug1": "glutethimide", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with paroxetine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with nimesulide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with clonidine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Aceclofenac.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with ethotoin.", "severity": 2}
{"drug1": "brotizolam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with doxepin.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with ESMOLOL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with propranolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with fenoprofen.", "severity": 2}
{"drug1": "brotizolam", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with nefazodone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with equilin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with meperidine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with cilazapril.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "haloperidol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with dibucaine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ketoprofen.", "severity": 2}
{"drug1": "celecoxib", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with epirizole.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with ethosuximide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with salicylamide.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with sertraline.", "severity": 2}
{"drug1": "Normethadone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with spironolactone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with methocarbamol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with triprolidine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with chlorthalidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with benzocaine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "isoflurane", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with clomipramine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with niflumic acid.", "severity": 2}
{"drug1": "meperidine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Fencamfamin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Propoxycaine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Pramocaine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with epirizole.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Pomalidomide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with butamben.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with SERTINDOLE.", "severity": 2}
{"drug1": "meclizine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with maprotiline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Ciclesonide.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Levomilnacipran.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with PROCATEROL.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Agomelatine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "valsartan", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with minoxidil.", "severity": 2}
{"drug1": "pentazocine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with zopiclone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with maprotiline.", "severity": 2}
{"drug1": "quinapril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "streptozocin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when streptozocin is combined with clozapine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with MELPERONE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with zotepine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with oxymorphone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Idelalisib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Idelalisib.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with brotizolam.", "severity": 2}
{"drug1": "sulindac", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Estrone sulfate.", "severity": 2}
{"drug1": "bromazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with etizolam.", "severity": 2}
{"drug1": "nefazodone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with tiapride.", "severity": 2}
{"drug1": "trandolapril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with tolmetin.", "severity": 2}
{"drug1": "codeine", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with trichlormethiazide.", "severity": 2}
{"drug1": "etizolam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with flunarizine.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with eperisone.", "severity": 2}
{"drug1": "codeine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with methoxyflurane.", "severity": 2}
{"drug1": "isoflurane", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with thiothixene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Pipotiazine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Remoxipride.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Lapatinib.", "severity": 2}
{"drug1": "meclizine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with primidone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with clonidine.", "severity": 2}
{"drug1": "zotepine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Olopatadine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Ramelteon.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with lisinopril.", "severity": 2}
{"drug1": "selegiline", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "selegiline", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Eplerenone.", "severity": 2}
{"drug1": "selegiline", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with methazolamide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Torasemide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with apraclonidine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Telmisartan.", "severity": 2}
{"drug1": "selegiline", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with SUFENTANIL.", "severity": 2}
{"drug1": "prazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Bretylium.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Aceprometazine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with zaltoprofen.", "severity": 2}
{"drug1": "epirizole", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Fluprednidene.", "severity": 2}
{"drug1": "epirizole", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with floctafenine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Normethadone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with felodipine.", "severity": 2}
{"drug1": "triazolam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with HEROIN.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with prazosin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with irbesartan.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with diflorasone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Flibanserin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with atenolol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with tetracaine.", "severity": 2}
{"drug1": "propofol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Levocetirizine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Butylscopolamine.", "severity": 2}
{"drug1": "propofol", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with amisulpride.", "severity": 2}
{"drug1": "Metixene", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with oxymorphone.", "severity": 2}
{"drug1": "temazepam", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "temazepam", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "temazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with duloxetine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Levalbuterol.", "severity": 2}
{"drug1": "topiramate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with MOLINDONE.", "severity": 2}
{"drug1": "citalopram", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with procarbazine.", "severity": 2}
{"drug1": "Lasofoxifene", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lasofoxifene is combined with Ospemifene.", "severity": 2}
{"drug1": "zopiclone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with cetirizine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with maprotiline.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with triamcinolone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with linezolid.", "severity": 2}
{"drug1": "zopiclone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with protriptyline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with amobarbital.", "severity": 2}
{"drug1": "ritodrine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with isoproterenol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with propofol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with gemfibrozil.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with fleroxacin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "meclizine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with fexofenadine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with antipyrine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with pimozide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with sotalol.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Normethadone.", "severity": 2}
{"drug1": "codeine", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with meprobamate.", "severity": 2}
{"drug1": "propofol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with MOLINDONE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with METAXALONE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Pizotifen.", "severity": 2}
{"drug1": "trazodone", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Cariprazine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Tixocortol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ILOPROST.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with benzocaine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with vigabatrin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with MELPERONE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with zotepine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with zotepine.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with venlafaxine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Lorcaserin.", "severity": 2}
{"drug1": "captopril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with hydralazine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with pimozide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Normethadone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with ZILEUTON.", "severity": 2}
{"drug1": "clorazepate", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "temazepam", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with morphine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with ADAPALENE.", "severity": 2}
{"drug1": "temazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with nortriptyline.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with ADAPALENE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with amoxapine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with epoprostenol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with efavirenz.", "severity": 2}
{"drug1": "fenbufen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with fluocinonide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Almotriptan.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Nebivolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with potassium ion.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ribostamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with ribostamycin.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "terbutaline", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "terbutaline", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with Ephedrine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with PROCATEROL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nifedipine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with clenbuterol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with topiramate.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Pregabalin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "bumetanide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with GUANFACINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Lurasidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "erythromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with erythromycin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with vigabatrin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with sotalol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with AMILORIDE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with lisinopril.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Tramadol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Desloratadine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "gabapentin", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with mepivacaine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Torasemide.", "severity": 2}
{"drug1": "reserpine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with HEROIN.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with citalopram.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Nebivolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Articaine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ramipril", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with minoxidil.", "severity": 2}
{"drug1": "Dexrazoxane", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexrazoxane is combined with clozapine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with spironolactone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with hydromorphone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with HEROIN.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with metoclopramide.", "severity": 2}
{"drug1": "memantine", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when memantine is combined with methacholine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Tolcapone.", "severity": 2}
{"drug1": "enalapril", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with lisinopril.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with sevoflurane.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with chlorprothixene.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Levocetirizine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with nalbuphine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with losartan.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with bromocriptine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Icatibant", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with epirizole.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with sertraline.", "severity": 2}
{"drug1": "isradipine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with tizanidine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with GUANFACINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with oxycodone.", "severity": 2}
{"drug1": "reserpine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with buspirone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with nefazodone.", "severity": 2}
{"drug1": "reserpine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with fosinopril.", "severity": 2}
{"drug1": "diflorasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with decamethonium.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with zotepine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with MELPERONE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with enflurane.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "disulfiram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lopinavir is combined with disulfiram.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Retigabine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with tetracaine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Pipotiazine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Pomalidomide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with zonisamide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Mephobarbital.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with clonazepam.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "dicumarol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with dicumarol.", "severity": 2}
{"drug1": "bifonazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Melatonin.", "severity": 2}
{"drug1": "selegiline", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Eplerenone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with thiamylal.", "severity": 2}
{"drug1": "selegiline", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with bumetanide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with desipramine.", "severity": 2}
{"drug1": "estazolam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with meclizine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Apremilast.", "severity": 2}
{"drug1": "quetiapine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Metipranolol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with ethosuximide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atomoxetine is combined with atorvastatin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with tioconazole.", "severity": 2}
{"drug1": "enalapril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Nebivolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with oxprenolol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with losartan.", "severity": 2}
{"drug1": "apomorphine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with papaverine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nifedipine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Miltefosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Miltefosine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Pentolinium.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Articaine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with carprofen.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ondansetron.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with METAXALONE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Fospropofol.", "severity": 2}
{"drug1": "desipramine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with clomipramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with isocarboxazid.", "severity": 2}
{"drug1": "zaleplon", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with thiothixene.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with oxaprozin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with flunarizine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with meclizine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with desoximetasone.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Amrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Amrubicin.", "severity": 2}
{"drug1": "diazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with benzocaine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with triamterene.", "severity": 2}
{"drug1": "diazepam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "diazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with maprotiline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Ramelteon.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with mesoridazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with nifedipine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with NAPROXEN.", "severity": 2}
{"drug1": "meperidine", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "sulindac", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with resveratrol.", "severity": 2}
{"drug1": "enflurane", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with protriptyline.", "severity": 2}
{"drug1": "cocaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "halothane", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Nitroprusside.", "severity": 2}
{"drug1": "clorazepate", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with SERTINDOLE.", "severity": 2}
{"drug1": "halothane", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Tolcapone.", "severity": 2}
{"drug1": "halothane", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with amitriptyline.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with indomethacin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Asenapine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "suprofen", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Salsalate.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoxsuprine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with nimodipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atazanavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "barnidipine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with valsartan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with pravastatin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Difenoxin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with lithium ion.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with ramipril.", "severity": 2}
{"drug1": "ioxilan", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ioxilan is combined with metformin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with clonidine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with amcinonide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with propranolol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "ceftriaxone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with ceftriaxone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Perospirone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with leflunomide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Temsirolimus.", "severity": 2}
{"drug1": "butenafine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with diltiazem.", "severity": 2}
{"drug1": "linezolid", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with droperidol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Oxetacaine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with zotepine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with epirizole.", "severity": 2}
{"drug1": "promazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Perospirone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with azelastine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with isoxsuprine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Pizotifen.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bismuth subcitrate potassium is combined with misoprostol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Difenoxin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Tixocortol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with chloroquine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with pramipexole.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with apraclonidine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with lisinopril.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Pramocaine.", "severity": 2}
{"drug1": "atenolol", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with benazepril.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with salicylamide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with chlormezanone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "pergolide", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Topiroxostat.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Salsalate.", "severity": 2}
{"drug1": "triprolidine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with levodopa.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Fencamfamin.", "severity": 2}
{"drug1": "levodopa", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Flibanserin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Cevimeline.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with nicotine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "sulindac", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Ramelteon.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Fluprednidene.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with efavirenz.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Bretylium.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Clobetasone.", "severity": 2}
{"drug1": "haloprogin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with eperisone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with fexofenadine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with bupropion.", "severity": 2}
{"drug1": "diflorasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with ambenonium.", "severity": 2}
{"drug1": "lorazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with tizanidine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Olopatadine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with flurazepam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with zotepine.", "severity": 2}
{"drug1": "aspirin", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with methylprednisolone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with dantrolene.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nicardipine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with efavirenz.", "severity": 2}
{"drug1": "cabergoline", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with testosterone.", "severity": 2}
{"drug1": "furosemide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with carvedilol.", "severity": 2}
{"drug1": "enalapril", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with nitroglycerin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with estazolam.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Tolcapone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with dipyridamole.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with tiapride.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "ethanol", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with paroxetine.", "severity": 2}
{"drug1": "imipramine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ESMOLOL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with lansoprazole.", "severity": 2}
{"drug1": "quinapril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with alclofenac.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with butamben.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with betamethasone.", "severity": 2}
{"drug1": "scopolamine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with fexofenadine.", "severity": 2}
{"drug1": "diazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with tetracaine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ADAPALENE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with protriptyline.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with teniposide.", "severity": 2}
{"drug1": "methadone", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "methadone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with furosemide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Milnacipran.", "severity": 2}
{"drug1": "alprazolam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with tiapride.", "severity": 2}
{"drug1": "linezolid", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with zotepine.", "severity": 2}
{"drug1": "linezolid", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with MELPERONE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Etidocaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Temsirolimus.", "severity": 2}
{"drug1": "methadone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with MELPERONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "promazine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Halazepam.", "severity": 2}
{"drug1": "promazine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with nortriptyline.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with amoxapine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with prochlorperazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with tetracaine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with cetirizine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with felodipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with mycophenolic acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with sparfloxacin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with sulindac.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with tretinoin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with tranylcypromine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Medroxyprogesterone acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "quazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Trabectedin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Trabectedin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Venetoclax", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Venetoclax.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Aceclofenac.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "pentostatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with pentostatin.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with felodipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Bendamustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Bendamustine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Pizotifen.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Mirabegron.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with medrysone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with doxepin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with mecamylamine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with triflupromazine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Torasemide.", "severity": 2}
{"drug1": "bepridil", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Canagliflozin.", "severity": 2}
{"drug1": "carprofen", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with resveratrol.", "severity": 2}
{"drug1": "aspirin", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with ibuprofen.", "severity": 2}
{"drug1": "reserpine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with diazepam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Lurasidone.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyzine is combined with paroxetine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Pipamperone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with flumethasone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with fexofenadine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Micafungin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with manidipine.", "severity": 2}
{"drug1": "clemastine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with carisoprodol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with raloxifene.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Mephobarbital.", "severity": 2}
{"drug1": "cabergoline", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Masoprocol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Aliskiren.", "severity": 2}
{"drug1": "aspirin", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Apremilast.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "aspirin", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with nadolol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Arformoterol.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with nortriptyline.", "severity": 2}
{"drug1": "procarbazine", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with dipivefrin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Methadyl acetate.", "severity": 2}
{"drug1": "carprofen", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with aspirin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with periciazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with meclizine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with halcinonide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with difluprednate.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with brotizolam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Torasemide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Pizotifen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Pramocaine.", "severity": 2}
{"drug1": "carprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with galanthamine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "vinblastine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinblastine is combined with leflunomide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Icatibant.", "severity": 2}
{"drug1": "sulpiride", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with cocaine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Propacetamol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Pramocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Propoxycaine.", "severity": 2}
{"drug1": "ketamine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with nitrous oxide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Efonidipine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIFABUTIN is combined with clopidogrel.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with chlormezanone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with phentolamine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with tizanidine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with furosemide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Olopatadine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with HEROIN.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with nalbuphine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with apraclonidine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with halcinonide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with mesoridazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Sunitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Sunitinib.", "severity": 2}
{"drug1": "procyclidine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "formestane", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with ROSOXACIN.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "suprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with medrysone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "nimodipine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with chlorothiazide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with zonisamide.", "severity": 2}
{"drug1": "sulindac", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with desoximetasone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with orphenadrine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with felodipine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with ifosfamide.", "severity": 2}
{"drug1": "pargyline", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with mianserin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with dibucaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with quinidine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with metolazone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with benzocaine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Bretylium.", "severity": 2}
{"drug1": "ethotoin", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with clidinium.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Remoxipride.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Tramadol.", "severity": 2}
{"drug1": "prazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "clonidine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with promethazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with clonazepam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with gabapentin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Mersalyl.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with oxaprozin.", "severity": 2}
{"drug1": "Propiverine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with codeine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with clidinium.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with nilvadipine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with flurandrenolide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Ketobemidone.", "severity": 2}
{"drug1": "benazepril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Propacetamol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with nitroglycerin.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with thioridazine.", "severity": 2}
{"drug1": "losartan", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with tolmetin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with lisinopril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Fluspirilene.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with fenoldopam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with irbesartan.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with oxprenolol.", "severity": 2}
{"drug1": "prazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with clomipramine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with etizolam.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with nicardipine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with metyrapone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with glyburide.", "severity": 2}
{"drug1": "medrysone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with physostigmine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with dantrolene.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with DEZOCINE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Pirlindole.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Toloxatone.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Lormetazepam.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Normethadone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with clozapine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "citalopram", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with rasagiline.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Ramelteon.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with ifosfamide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with zotepine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with MELPERONE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "pergolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with pergolide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with fosinopril.", "severity": 2}
{"drug1": "loxapine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with dyclonine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with atorvastatin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with pimozide.", "severity": 2}
{"drug1": "medrysone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with rivastigmine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with flunitrazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "propofol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Ketobemidone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with desipramine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with GUANFACINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Tixocortol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with metoclopramide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with thiamylal.", "severity": 2}
{"drug1": "suprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with formestane.", "severity": 2}
{"drug1": "lidocaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with halothane.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with paroxetine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with bromocriptine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with sulindac.", "severity": 2}
{"drug1": "cilazapril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with chloroquine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with medrysone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with rescinnamine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with pimozide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with quazepam.", "severity": 2}
{"drug1": "etizolam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with tizanidine.", "severity": 2}
{"drug1": "Butethal", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with phenytoin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with flunitrazepam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "zaleplon", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with oxprenolol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Efonidipine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with clonazepam.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with levodopa.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with azelastine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with fexofenadine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with felodipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Mephobarbital.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with rivastigmine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with moclobemide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ACENOCOUMAROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with pentazocine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with physostigmine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Pipotiazine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with trazodone.", "severity": 2}
{"drug1": "meperidine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with lithium ion.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Butylscopolamine.", "severity": 2}
{"drug1": "etizolam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with cetirizine.", "severity": 2}
{"drug1": "risperidone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with ethotoin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Flupentixol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with nicardipine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with MOLINDONE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with dichlorphenamide.", "severity": 2}
{"drug1": "proparacaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with cetirizine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with protriptyline.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Aceclofenac.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Ciclesonide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with tacrolimus.", "severity": 2}
{"drug1": "triamterene", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with metolazone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Olopatadine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ranitidine.", "severity": 2}
{"drug1": "triamterene", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Vecuronium.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Aliskiren.", "severity": 2}
{"drug1": "perphenazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with HEROIN.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with levorphanol.", "severity": 2}
{"drug1": "propofol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with methyclothiazide.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with morphine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Indacaterol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with MOLINDONE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Pramocaine.", "severity": 2}
{"drug1": "nystatin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Pinaverium.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Escitalopram.", "severity": 2}
{"drug1": "reserpine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Propoxycaine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Deferasirox.", "severity": 2}
{"drug1": "halothane", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Clevidipine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "cocaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with ethosuximide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with procaine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Sacubitril.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Ramelteon.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with alclometasone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with terazosin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with nortriptyline.", "severity": 2}
{"drug1": "HEROIN", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with amoxapine.", "severity": 2}
{"drug1": "triamterene", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with cilazapril.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Escitalopram.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Pipamperone.", "severity": 2}
{"drug1": "equilin", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with cinoxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with GUANFACINE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with felbamate.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with quetiapine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with doxepin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with clemastine.", "severity": 2}
{"drug1": "imipramine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with efavirenz.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with venlafaxine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with floctafenine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with olanzapine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Clevidipine.", "severity": 2}
{"drug1": "propantheline", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Tramadol.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with bepridil.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with phenytoin.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with eperisone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with dipyridamole.", "severity": 2}
{"drug1": "procarbazine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with perphenazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with flunitrazepam.", "severity": 2}
{"drug1": "Etomidate", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "etodolac", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with diflorasone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with butamben.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with ADAPALENE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Tasimelteon.", "severity": 2}
{"drug1": "donepezil", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when donepezil is combined with pilocarpine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with efavirenz.", "severity": 2}
{"drug1": "triazolam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Tixocortol.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with fluoxetine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with duloxetine.", "severity": 2}
{"drug1": "propofol", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with DESFLURANE.", "severity": 2}
{"drug1": "methazolamide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with apraclonidine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with topiramate.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Telmisartan.", "severity": 2}
{"drug1": "equilin", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Gemifloxacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Propacetamol.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with loteprednol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "methazolamide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with methyldopa.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with GUANFACINE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with maprotiline.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with loratadine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with CLONIXIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with amisulpride.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Desloratadine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with tizanidine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with ethotoin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Loxoprofen.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with epirizole.", "severity": 2}
{"drug1": "meclizine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with clidinium.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Oxetacaine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with phenytoin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Etomidate.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Flibanserin.", "severity": 2}
{"drug1": "valsartan", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Telmisartan.", "severity": 2}
{"drug1": "estazolam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with morphine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with mefloquine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with promethazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with estrone.", "severity": 2}
{"drug1": "valsartan", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with methyldopa.", "severity": 2}
{"drug1": "diclofenac", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "diclofenac", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with amcinonide.", "severity": 2}
{"drug1": "pimozide", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "dibucaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with carisoprodol.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Masoprocol.", "severity": 2}
{"drug1": "irbesartan", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with ramipril.", "severity": 2}
{"drug1": "procyclidine", "drug2": "ethopropazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with ethopropazine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Halobetasol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with loratadine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with levodopa.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with propoxyphene.", "severity": 2}
{"drug1": "floctafenine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with nisoldipine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with clonidine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with zaltoprofen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with perphenazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with flunitrazepam.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "pimozide", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Pipotiazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with tizanidine.", "severity": 2}
{"drug1": "baclofen", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with trimipramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with phentolamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with citalopram.", "severity": 2}
{"drug1": "risperidone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with fludiazepam.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Ximelagatran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Ximelagatran.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with propofol.", "severity": 2}
{"drug1": "risperidone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with chloral hydrate.", "severity": 2}
{"drug1": "citalopram", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with tiapride.", "severity": 2}
{"drug1": "procaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Pizotifen.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Fosphenytoin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Vecuronium.", "severity": 2}
{"drug1": "estazolam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Halazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with proparacaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with triamcinolone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with haloperidol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with venlafaxine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ethosuximide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Loxoprofen.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with orphenadrine.", "severity": 2}
{"drug1": "morphine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with deslanoside.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Difenoxin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with nifedipine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Halobetasol.", "severity": 2}
{"drug1": "morphine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with proparacaine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with sulfasalazine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with alclofenac.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM HYDROXIDE is combined with misoprostol.", "severity": 2}
{"drug1": "temazepam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Paliperidone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with dibucaine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Arformoterol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Lorcaserin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with tranylcypromine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with alclofenac.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Fluprednidene.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with zotepine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with chlorprothixene.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with sevoflurane.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with chlorthalidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with thalidomide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Gatifloxacin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with bromazepam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with fludiazepam.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with carvedilol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Cariprazine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Torasemide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "enflurane", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with sertraline.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Empagliflozin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with aspirin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Fluprednidene.", "severity": 2}
{"drug1": "Tramadol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with fexofenadine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with naratriptan.", "severity": 2}
{"drug1": "Tramadol", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with rizatriptan.", "severity": 2}
{"drug1": "temazepam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with oxymorphone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Normethadone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Iloperidone.", "severity": 2}
{"drug1": "sotalol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with irbesartan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with hydralazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with methocarbamol.", "severity": 2}
{"drug1": "Trospium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "sotalol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with felodipine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with procarbazine.", "severity": 2}
{"drug1": "sotalol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Salmeterol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with enflurane.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Metixene.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Aripiprazole.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with olanzapine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with mesoridazine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with halcinonide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with difluprednate.", "severity": 2}
{"drug1": "moclobemide", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with maprotiline.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Milnacipran.", "severity": 2}
{"drug1": "reserpine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with butalbital.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Salsalate.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Articaine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with mefloquine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Repaglinide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "pergolide", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with metronidazole.", "severity": 2}
{"drug1": "proparacaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with triflupromazine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with carvedilol.", "severity": 2}
{"drug1": "linezolid", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with promethazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with etizolam.", "severity": 2}
{"drug1": "benzocaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Torasemide.", "severity": 2}
{"drug1": "methadone", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with meperidine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Empagliflozin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "isradipine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Cyamemazine.", "severity": 2}
{"drug1": "methadone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with imipramine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with budesonide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with glutethimide.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with quetiapine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with paroxetine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with methylprednisolone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with clidinium.", "severity": 2}
{"drug1": "dantrolene", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with fluoxetine.", "severity": 2}
{"drug1": "topiramate", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with efavirenz.", "severity": 2}
{"drug1": "dantrolene", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with duloxetine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "tretinoin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with cilazapril.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with glutethimide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with topiramate.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with thiothixene.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Desloratadine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with chloral hydrate.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Indacaterol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with pramipexole.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with tetracaine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with amisulpride.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Efonidipine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Pregabalin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with acemetacin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with fosinopril.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Butethal.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with clenbuterol.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Normethadone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with losartan.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with lithium ion.", "severity": 2}
{"drug1": "reserpine", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with digitoxin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "meperidine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with D-mannitol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with furosemide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with tubocurarine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with tizanidine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "quazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "valsartan", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Nebivolol.", "severity": 2}
{"drug1": "indapamide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with digitoxin.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with CLONIXIN.", "severity": 2}
{"drug1": "indomethacin", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with meclofenamic acid.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with enflurane.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "risperidone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Normethadone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Fluspirilene.", "severity": 2}
{"drug1": "carprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with salicylic acid.", "severity": 2}
{"drug1": "docetaxel", "drug2": "tegafur", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with tegafur.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Apremilast.", "severity": 2}
{"drug1": "methadone", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with polythiazide.", "severity": 2}
{"drug1": "morphine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Levocetirizine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Clobetasone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with fenoldopam.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with nylidrin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with clonidine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with linezolid.", "severity": 2}
{"drug1": "nabumetone", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with fluocinonide.", "severity": 2}
{"drug1": "midazolam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with cocaine.", "severity": 2}
{"drug1": "imipramine", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with dextromethorphan.", "severity": 2}
{"drug1": "Propiverine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Ethylmorphine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with acebutolol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with captopril.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with topiramate.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with loratadine.", "severity": 2}
{"drug1": "pimozide", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with etizolam.", "severity": 2}
{"drug1": "floctafenine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with diflunisal.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with cetirizine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Butethal.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with metaproterenol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Tapentadol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Cangrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Cangrelor.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nilvadipine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with dyclonine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with zonisamide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with tiagabine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with cocaine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with ondansetron.", "severity": 2}
{"drug1": "Apremilast", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with fludrocortisone.", "severity": 2}
{"drug1": "citalopram", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with rizatriptan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with celecoxib.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with bupivacaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Ropivacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Teriflunomide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Etomidate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with paramethasone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Hexobarbital.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Etidronic acid.", "severity": 2}
{"drug1": "isoflurane", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with GUANFACINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with flunitrazepam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Phenelzine.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaliplatin is combined with leflunomide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Cyamemazine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with Tasimelteon.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with clomipramine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with propofol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with trandolapril.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with medrysone.", "severity": 2}
{"drug1": "reserpine", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with carprofen.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with nifedipine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with lisinopril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with sotalol.", "severity": 2}
{"drug1": "buspirone", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ALFENTANIL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with ethotoin.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with nitroglycerin.", "severity": 2}
{"drug1": "ethotoin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "buspirone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with proparacaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with loteprednol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Nabilone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Apremilast.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with nitric oxide.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Alvimopan.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with maprotiline.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with isoetharine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with SUFENTANIL.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Darunavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Darunavir.", "severity": 2}
{"drug1": "felodipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with captopril.", "severity": 2}
{"drug1": "metolazone", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Riociguat.", "severity": 2}
{"drug1": "felodipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with acebutolol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with atenolol.", "severity": 2}
{"drug1": "naratriptan", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with selegiline.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with thioridazine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Conivaptan.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with mesoridazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "prazosin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with tizanidine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Salsalate.", "severity": 2}
{"drug1": "Melatonin", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with amoxapine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with nortriptyline.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with meperidine.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SULFAMOXOLE is combined with mecamylamine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with hydrocortisone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with benzocaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Difenoxin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Mersalyl.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with vigabatrin.", "severity": 2}
{"drug1": "cocaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with lithium ion.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Olopatadine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with ketoprofen.", "severity": 2}
{"drug1": "cocaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Butethal.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Mersalyl.", "severity": 2}
{"drug1": "nabumetone", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with alclometasone.", "severity": 2}
{"drug1": "papaverine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with trifluoperazine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Ciclesonide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Ketobemidone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with pilocarpine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with dantrolene.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with nitrous oxide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Pipamperone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with bifonazole.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with clonidine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Articaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Iloperidone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Ramelteon.", "severity": 2}
{"drug1": "levodopa", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with rasagiline.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "butalbital", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with flunarizine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Agomelatine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with tiapride.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with malathion.", "severity": 2}
{"drug1": "diazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with ondansetron.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with efavirenz.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with budesonide.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with sertraline.", "severity": 2}
{"drug1": "benztropine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with efavirenz.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "suprofen", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with ibuprofen.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with clorazepate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with alclometasone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "HEROIN", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with selegiline.", "severity": 2}
{"drug1": "budesonide", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with pimozide.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Desloratadine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with thalidomide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with diflunisal.", "severity": 2}
{"drug1": "zopiclone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with zonisamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with cocaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with tiagabine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Fospropofol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with ondansetron.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with periciazine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Normethadone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with oxaprozin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Aliskiren.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Nintedanib.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Aceprometazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with sevoflurane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Fospropofol.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Cyamemazine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with indomethacin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Difenoxin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with glutethimide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with flunarizine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "epinastine", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with Apixaban.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Nitroprusside.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with prazepam.", "severity": 2}
{"drug1": "pimozide", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with cetirizine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Pipotiazine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Thioproperazine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with thiothixene.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with resveratrol.", "severity": 2}
{"drug1": "enflurane", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with clonazepam.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Pizotifen.", "severity": 2}
{"drug1": "nimodipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with atorvastatin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "buspirone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with glutethimide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "cocaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with ethotoin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with cetirizine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with streptozocin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with nimesulide.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with protriptyline.", "severity": 2}
{"drug1": "thiopental", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with sertraline.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with carprofen.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Phenelzine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Difenoxin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with fenbufen.", "severity": 2}
{"drug1": "imipramine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with galanthamine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with venlafaxine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "tibolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with tibolone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Fospropofol.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "estazolam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with tetracaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with haloperidol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Zoledronic acid.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Phenelzine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with bepridil.", "severity": 2}
{"drug1": "nimesulide", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with tizanidine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "quazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with duloxetine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with methscopolamine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with SERATRODAST.", "severity": 2}
{"drug1": "promazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with brotizolam.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with codeine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with nifedipine.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with lovastatin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with quetiapine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with zaltoprofen.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Aceclofenac.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Niraparib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Niraparib.", "severity": 2}
{"drug1": "ethanol", "drug2": "Rufinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Rufinamide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with triprolidine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with methylphenidate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with methocarbamol.", "severity": 2}
{"drug1": "methysergide", "drug2": "Quinine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Quinine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Loxoprofen.", "severity": 2}
{"drug1": "ibudilast", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with Apixaban.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with indapamide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with medrysone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Flupentixol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with rapamycin.", "severity": 2}
{"drug1": "morphine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Oxetacaine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Paliperidone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "oxycodone", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with clidinium.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with fludrocortisone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Mivacurium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Mivacurium.", "severity": 2}
{"drug1": "furosemide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with mecamylamine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with haloperidol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with benzocaine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nimodipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Lofexidine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with ethosuximide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Flupentixol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Apremilast.", "severity": 2}
{"drug1": "meperidine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Tolcapone.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium acetate is combined with Calcipotriol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Olopatadine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Tapentadol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with homoharringtonine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with SERTINDOLE.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with clidinium.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Butethal.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "enalapril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Sacubitril.", "severity": 2}
{"drug1": "suprofen", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with azelastine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with HEROIN.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with tiapride.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with galanthamine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with Isoflurophate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Pipamperone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Flibanserin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with furosemide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with tizanidine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with ZILEUTON.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Flibanserin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Difenoxin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "clonidine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with mecamylamine.", "severity": 2}
{"drug1": "bepridil", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with dipyridamole.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Butethal.", "severity": 2}
{"drug1": "lorazepam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with amobarbital.", "severity": 2}
{"drug1": "Mometasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with enoxacin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with lithium ion.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "fosinopril", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with metolazone.", "severity": 2}
{"drug1": "reserpine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nimodipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Melatonin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with clonazepam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with promethazine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Canagliflozin.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with tolmetin.", "severity": 2}
{"drug1": "reserpine", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with digoxin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with hydrocortisone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Propoxycaine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with clomipramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Pramocaine.", "severity": 2}
{"drug1": "terconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with gabapentin.", "severity": 2}
{"drug1": "methysergide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Iloperidone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with xylometazoline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with methyclothiazide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ketamine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Fospropofol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with nadolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "RANOLAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with RANOLAZINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with chlorzoxazone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Etomidate.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with perphenazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Ropivacaine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with bupivacaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with triprolidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with lidocaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with methocarbamol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with methylphenidate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Iloperidone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Pipamperone.", "severity": 2}
{"drug1": "Micafungin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with alclometasone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with nortriptyline.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with amoxapine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with benazepril.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Olsalazine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with ALFENTANIL.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with ethotoin.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with promethazine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with clonazepam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with bumetanide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with chlorothiazide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Echothiophate.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with norfloxacin.", "severity": 2}
{"drug1": "clonazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with doxepin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with halothane.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ibuprofen.", "severity": 2}
{"drug1": "Icatibant", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with prednisone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with modafinil.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with methylprednisolone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with hydrocortisone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with D-mannitol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with butalbital.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with simvastatin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with memantine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pravastatin is combined with atorvastatin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nimodipine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with SERATRODAST.", "severity": 2}
{"drug1": "trandolapril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with meclizine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with zaltoprofen.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Aceclofenac.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with nisoldipine.", "severity": 2}
{"drug1": "losartan", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Clevidipine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with trimipramine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with nadolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "metoprolol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "leflunomide", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with resveratrol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Nepafenac.", "severity": 2}
{"drug1": "lidocaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with trifluoperazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with clidinium.", "severity": 2}
{"drug1": "tetracaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "sulindac", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with DESONIDE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with flunarizine.", "severity": 2}
{"drug1": "aspirin", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with mesalamine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with ketoprofen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "busulfan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with busulfan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "hydroxyurea", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with hydroxyurea.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Pipamperone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with trimipramine.", "severity": 2}
{"drug1": "etizolam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with cinoxacin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with procarbazine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Lornoxicam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with HEROIN.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Pomalidomide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with physostigmine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with PAMABROM.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with flurazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with doxepin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with tolmetin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with rivastigmine.", "severity": 2}
{"drug1": "furosemide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with deslanoside.", "severity": 2}
{"drug1": "ketamine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with desipramine.", "severity": 2}
{"drug1": "morphine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ketamine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with thiamylal.", "severity": 2}
{"drug1": "ketamine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with halothane.", "severity": 2}
{"drug1": "felbamate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with levodopa.", "severity": 2}
{"drug1": "pramipexole", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Clevidipine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with penbutolol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with GUANFACINE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ketamine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with fenbufen.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with chlorpheniramine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Clodronic Acid.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mitoxantrone is combined with atorvastatin.", "severity": 2}
{"drug1": "morphine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Remoxipride.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with trazodone.", "severity": 2}
{"drug1": "Butethal", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with GUANFACINE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with apraclonidine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Paliperidone.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with barnidipine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Telmisartan.", "severity": 2}
{"drug1": "tiapride", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with nortriptyline.", "severity": 2}
{"drug1": "tiapride", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with amoxapine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with methocarbamol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with triprolidine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Propacetamol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with etodolac.", "severity": 2}
{"drug1": "pancuronium", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with methadone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with chlorprothixene.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with budesonide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with brotizolam.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with metoclopramide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with cilazapril.", "severity": 2}
{"drug1": "oxycodone", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with triazolam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with benzocaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with vigabatrin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "TRIMETAZIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with TRIMETAZIDINE.", "severity": 2}
{"drug1": "propofol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Flibanserin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Tasimelteon.", "severity": 2}
{"drug1": "Capsaicin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Capsaicin is combined with atorvastatin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with losartan.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with dantrolene.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with eperisone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Ramelteon.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with dorzolamide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Oxetacaine.", "severity": 2}
{"drug1": "codeine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with meperidine.", "severity": 2}
{"drug1": "codeine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with loratadine.", "severity": 2}
{"drug1": "etodolac", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with antipyrine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Retigabine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "quinapril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ketoprofen.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with methocarbamol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with Temsirolimus.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Pimecrolimus.", "severity": 2}
{"drug1": "citalopram", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with sumatriptan.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Benidipine.", "severity": 2}
{"drug1": "azelastine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with methylprednisolone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with tetracaine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Milnacipran.", "severity": 2}
{"drug1": "estazolam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with vigabatrin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Riociguat.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with morphine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Fospropofol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with linezolid.", "severity": 2}
{"drug1": "protriptyline", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with nortriptyline.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Sacubitril.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "metaraminol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with metaraminol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Halazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with proparacaine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with doxepin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with primidone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with captopril.", "severity": 2}
{"drug1": "phentolamine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "oxycodone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with methyclothiazide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with antipyrine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with pentazocine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Pramocaine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Propoxycaine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with mecamylamine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with Ezetimibe.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with amoxapine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with propantheline.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with nortriptyline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with hydralazine.", "severity": 2}
{"drug1": "equilin", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with rivastigmine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Mephobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with proparacaine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Halazepam.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with felodipine.", "severity": 2}
{"drug1": "risperidone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Metixene", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with pentazocine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Levocetirizine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Vapreotide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Vapreotide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with acetylcholine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with fenbufen.", "severity": 2}
{"drug1": "halothane", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with captopril.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with clonidine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Levalbuterol.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Deferasirox.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with quetiapine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Fluprednidene.", "severity": 2}
{"drug1": "equilin", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with galanthamine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Etidocaine.", "severity": 2}
{"drug1": "equilin", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Isoflurophate.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Risedronic acid.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Mephobarbital.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with clomipramine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Pramocaine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with fludiazepam.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with salicylamide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with butamben.", "severity": 2}
{"drug1": "prazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Tapentadol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Lapatinib.", "severity": 2}
{"drug1": "fenbufen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with CLONIXIN.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with ethosuximide.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Temsirolimus is combined with rescinnamine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Etidocaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with dantrolene.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with methadone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with salicylic acid.", "severity": 2}
{"drug1": "baclofen", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Tasimelteon.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Mephobarbital.", "severity": 2}
{"drug1": "zopiclone", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with estazolam.", "severity": 2}
{"drug1": "clidinium", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Retigabine.", "severity": 2}
{"drug1": "estazolam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with butamben.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with scopolamine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with procarbazine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with reserpine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "felodipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Clevidipine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with CLONIXIN.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with tolfenamic acid.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Iloperidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with nefazodone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with clidinium.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Loxoprofen.", "severity": 2}
{"drug1": "loratadine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with trimipramine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with norfloxacin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Empagliflozin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with scopolamine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "pergolide", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Lomitapide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "zolpidem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with zolpidem.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with dyclonine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with OLODATEROL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Vilanterol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with methocarbamol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with loratadine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "timolol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with acebutolol.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "Emtricitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with Emtricitabine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Olopatadine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "prazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Amrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Amrubicin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with simvastatin.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eluxadoline is combined with Naloxegol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "timolol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with captopril.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Difenoxin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with pimozide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with fenbufen.", "severity": 2}
{"drug1": "amiodarone", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with ILOPROST.", "severity": 2}
{"drug1": "thiopental", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Lormetazepam.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with chlorothiazide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with quinapril.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with alclofenac.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Metipranolol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with cocaine.", "severity": 2}
{"drug1": "Trospium", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with pirenzepine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with nifedipine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with nitrazepam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with papaverine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with chloroquine.", "severity": 2}
{"drug1": "indapamide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with felodipine.", "severity": 2}
{"drug1": "indapamide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with carvedilol.", "severity": 2}
{"drug1": "clozapine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with atorvastatin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ambroxol.", "severity": 2}
{"drug1": "indapamide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with irbesartan.", "severity": 2}
{"drug1": "alclofenac", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with estrone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Remoxipride.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with spironolactone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Levocetirizine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with SERTINDOLE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with methazolamide.", "severity": 2}
{"drug1": "codeine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with oxymorphone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Rivaroxaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with butalbital.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Estrone sulfate.", "severity": 2}
{"drug1": "morphine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with nabumetone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with HEROIN.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Difenoxin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with ketorolac.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Aripiprazole.", "severity": 2}
{"drug1": "pergolide", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with nicotinamide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with sevoflurane.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with tenoxicam.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Risedronic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with levodopa.", "severity": 2}
{"drug1": "Tramadol", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with metoclopramide.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nimesulide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with fexofenadine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Salmeterol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Levetiracetam.", "severity": 2}
{"drug1": "trimipramine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with maprotiline.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with lovastatin.", "severity": 2}
{"drug1": "reserpine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with amobarbital.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with reserpine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Ketobemidone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with lithium ion.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with acetylcholine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nicardipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with efavirenz.", "severity": 2}
{"drug1": "selegiline", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with methyclothiazide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with clonazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with promethazine.", "severity": 2}
{"drug1": "codeine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "pergolide", "drug2": "amprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with amprenavir.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Mersalyl.", "severity": 2}
{"drug1": "pergolide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with methazolamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with olanzapine.", "severity": 2}
{"drug1": "linezolid", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with olanzapine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Amrinone.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Normethadone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with clidinium.", "severity": 2}
{"drug1": "temazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with prednisone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with felodipine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Ketobemidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Butethal.", "severity": 2}
{"drug1": "terazosin", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Canagliflozin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spiramycin is combined with Pitavastatin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with loratadine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with daunorubicin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with decamethonium.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with ibuprofen.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with imipramine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Perospirone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with fenoprofen.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Olopatadine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with topiramate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with triflupromazine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with promethazine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with clonazepam.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "biperiden", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with cyclopentolate.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with ethotoin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with promethazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with clonazepam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Melatonin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with nimodipine.", "severity": 2}
{"drug1": "propantheline", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Normethadone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with carisoprodol.", "severity": 2}
{"drug1": "isradipine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with carisoprodol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with topiramate.", "severity": 2}
{"drug1": "apomorphine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with felodipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with buspirone.", "severity": 2}
{"drug1": "selegiline", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with oxycodone.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with DEZOCINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with tizanidine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with clidinium.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with clonazepam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "pimozide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with papaverine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with fludiazepam.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "zidovudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxorubicin is combined with zidovudine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Milnacipran.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Riociguat.", "severity": 2}
{"drug1": "olanzapine", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with meprobamate.", "severity": 2}
{"drug1": "prazosin", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with furosemide.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PRIMAQUINE is combined with mefloquine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Ramelteon.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with cilostazol.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with fluvastatin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with trifluoperazine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with diflunisal.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with buprenorphine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with procarbazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with arsenic trioxide.", "severity": 2}
{"drug1": "ethionamide", "drug2": "D-cycloserine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethionamide is combined with D-cycloserine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with budesonide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with formestane.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Pizotifen.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with paramethasone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with MOXONIDINE.", "severity": 2}
{"drug1": "ethotoin", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with felbamate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with clemastine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with biperiden.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Agomelatine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with quetiapine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "reserpine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with fludiazepam.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Pipamperone.", "severity": 2}
{"drug1": "reserpine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chloral hydrate.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with duloxetine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with suprofen.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with celiprolol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with chloroquine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "BENZNIDAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with BENZNIDAZOLE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with oxazepam.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with butamben.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with sulindac.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with aspirin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "PHENPROCOUMON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Nabilone", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with quinapril.", "severity": 2}
{"drug1": "Nabilone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with chlorothiazide.", "severity": 2}
{"drug1": "Nabilone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with leflunomide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with periciazine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "DEXKETOPROFEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with DEXKETOPROFEN.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Bambuterol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with estrone.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with paroxetine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with budesonide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Ketobemidone.", "severity": 2}
{"drug1": "isradipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Aliskiren.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with prazosin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with quinapril.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with buspirone.", "severity": 2}
{"drug1": "methysergide", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with testosterone.", "severity": 2}
{"drug1": "methysergide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with efavirenz.", "severity": 2}
{"drug1": "methysergide", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nicardipine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Clodronic Acid.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Clodronic Acid.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with nalbuphine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with tiapride.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with METAXALONE.", "severity": 2}
{"drug1": "Benidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with irbesartan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with butamben.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Articaine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Demecarium.", "severity": 2}
{"drug1": "lorazepam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with estazolam.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Metixene.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with ESMOLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Nebivolol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with thiothixene.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Thioproperazine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Pramocaine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with cinoxacin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Levalbuterol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with butalbital.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with meclizine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with Apixaban.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with triflupromazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with MOLINDONE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ritonavir.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with butamben.", "severity": 2}
{"drug1": "midazolam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with methoxyflurane.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with phenytoin.", "severity": 2}
{"drug1": "enflurane", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with HEROIN.", "severity": 2}
{"drug1": "zaleplon", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Capsaicin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with amisulpride.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Propacetamol.", "severity": 2}
{"drug1": "enflurane", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Levetiracetam.", "severity": 2}
{"drug1": "barnidipine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Iloperidone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "methadone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with fluoxetine.", "severity": 2}
{"drug1": "suprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "morphine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with papaverine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with duloxetine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Flibanserin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Halobetasol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Ciclesonide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with vigabatrin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with ethotoin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with fluvoxamine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with enflurane.", "severity": 2}
{"drug1": "nicardipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with acebutolol.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with enoxacin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "oxazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with isoflurane.", "severity": 2}
{"drug1": "zotepine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with maprotiline.", "severity": 2}
{"drug1": "pentazocine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with salicylamide.", "severity": 2}
{"drug1": "tetracaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Propiverine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Ramelteon.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with docetaxel.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with nitroglycerin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with spironolactone.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorouracil is combined with clozapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with benzyl alcohol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with dantrolene.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with Pitavastatin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with moclobemide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Teriflunomide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with trimipramine.", "severity": 2}
{"drug1": "losartan", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with mycophenolic acid.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with primidone.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with vincristine.", "severity": 2}
{"drug1": "losartan", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "losartan", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with felodipine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "losartan", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with irbesartan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Etidocaine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with minoxidil.", "severity": 2}
{"drug1": "zaleplon", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with baclofen.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Milnacipran.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Canagliflozin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "sulindac", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "methoxamine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with terbutaline.", "severity": 2}
{"drug1": "thiopental", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "thiopental", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Fluspirilene.", "severity": 2}
{"drug1": "imipramine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "butamben", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with paroxetine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with mycophenolic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Etidronic acid.", "severity": 2}
{"drug1": "probenecid", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when probenecid is combined with Torasemide.", "severity": 2}
{"drug1": "papaverine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Metipranolol.", "severity": 2}
{"drug1": "papaverine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Difenoxin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with amoxapine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with carisoprodol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with thioridazine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "polythiazide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Oxetacaine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with tiapride.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Salmeterol.", "severity": 2}
{"drug1": "atenolol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with mecamylamine.", "severity": 2}
{"drug1": "aspirin", "drug2": "DEXKETOPROFEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with DEXKETOPROFEN.", "severity": 2}
{"drug1": "morphine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with tolazoline.", "severity": 2}
{"drug1": "morphine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Nabilone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Butethal.", "severity": 2}
{"drug1": "aspirin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with sotalol.", "severity": 2}
{"drug1": "labetalol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with losartan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with lithium ion.", "severity": 2}
{"drug1": "amifostine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with primidone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with equilin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Perospirone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with diflunisal.", "severity": 2}
{"drug1": "bepridil", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with diltiazem.", "severity": 2}
{"drug1": "dopamine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with antipyrine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with propoxyphene.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with fluvastatin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with levodopa.", "severity": 2}
{"drug1": "benztropine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with oxybutynin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with isoproterenol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with estrone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Potassium citrate.", "severity": 2}
{"drug1": "nimodipine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with carvedilol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with methocarbamol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with methylphenidate.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with malathion.", "severity": 2}
{"drug1": "procaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with trimipramine.", "severity": 2}
{"drug1": "carmustine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carmustine is combined with leflunomide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with nalidixic acid.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with penbutolol.", "severity": 2}
{"drug1": "HEROIN", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with butalbital.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Olopatadine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Retigabine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with salicylic acid.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with propoxyphene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with diphenhydramine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Levocetirizine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Levomilnacipran.", "severity": 2}
{"drug1": "zonisamide", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with paroxetine.", "severity": 2}
{"drug1": "ketamine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with amisulpride.", "severity": 2}
{"drug1": "imipramine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with citalopram.", "severity": 2}
{"drug1": "imipramine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Torasemide.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with amoxapine.", "severity": 2}
{"drug1": "Butethal", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with scopolamine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with dyclonine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with propoxyphene.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with methocarbamol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with tiapride.", "severity": 2}
{"drug1": "losartan", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with resveratrol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "tiagabine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with resveratrol.", "severity": 2}
{"drug1": "estazolam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Benidipine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with gabapentin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "pargyline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with moclobemide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ifosfamide is combined with atorvastatin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with fenbufen.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Etidronic acid.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Articaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with triprolidine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "methysergide", "drug2": "SIMEPREVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "methazolamide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with irbesartan.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with maprotiline.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with diflunisal.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Phenelzine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with promazine.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with fluvastatin.", "severity": 2}
{"drug1": "estazolam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with imipramine.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with oxycodone.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with rasagiline.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with tiagabine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with zonisamide.", "severity": 2}
{"drug1": "zotepine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with dantrolene.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Pizotifen.", "severity": 2}
{"drug1": "sulindac", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with niflumic acid.", "severity": 2}
{"drug1": "risperidone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with meclizine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with indomethacin.", "severity": 2}
{"drug1": "amifostine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with mecamylamine.", "severity": 2}
{"drug1": "clonidine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "benazepril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with floctafenine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with Dapagliflozin.", "severity": 2}
{"drug1": "ketamine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with dyclonine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Pramocaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with lidocaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with tiapride.", "severity": 2}
{"drug1": "prilocaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with fludiazepam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Lormetazepam.", "severity": 2}
{"drug1": "sulfacytine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfacytine is combined with mecamylamine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with loteprednol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with brotizolam.", "severity": 2}
{"drug1": "citric acid", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citric acid is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "spironolactone", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with cilazapril.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with tiapride.", "severity": 2}
{"drug1": "sulfaphenazole", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfaphenazole is combined with mecamylamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ketamine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with hydrocortisone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with quetiapine.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "lamivudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with lamivudine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with promethazine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with topiramate.", "severity": 2}
{"drug1": "naratriptan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Articaine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nilvadipine.", "severity": 2}
{"drug1": "medrysone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with fleroxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "temazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with periciazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Tasimelteon.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "minoxidil", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with decamethonium.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Levetiracetam.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with ESMOLOL.", "severity": 2}
{"drug1": "suprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Olopatadine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Milnacipran.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with salicylamide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with flunisolide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Propacetamol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Clofarabine.", "severity": 2}
{"drug1": "loxapine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with methoxyflurane.", "severity": 2}
{"drug1": "butalbital", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with fluoxetine.", "severity": 2}
{"drug1": "butalbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with duloxetine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Aceprometazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with amitriptyline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with nitrazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with MOLINDONE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with amisulpride.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Normethadone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Flibanserin.", "severity": 2}
{"drug1": "sulindac", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with paramethasone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Fesoterodine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with gabapentin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with Pitavastatin.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with trimipramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nitroglycerin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with procaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with lisinopril.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with isoproterenol.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "triazolam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with triamcinolone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with metoclopramide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nitroglycerin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with trimipramine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with lisinopril.", "severity": 2}
{"drug1": "lidocaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with METAXALONE.", "severity": 2}
{"drug1": "cimetidine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cimetidine is combined with phenytoin.", "severity": 2}
{"drug1": "losartan", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Spirapril.", "severity": 2}
{"drug1": "flurazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with nitroglycerin.", "severity": 2}
{"drug1": "losartan", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with cilazapril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "papaverine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Aliskiren.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Tramadol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with citalopram.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Torasemide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with enflurane.", "severity": 2}
{"drug1": "quinidine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with tolazoline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Metipranolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Etidocaine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with prochlorperazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with minoxidil.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Retigabine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with nortriptyline.", "severity": 2}
{"drug1": "nimodipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with acebutolol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with felbamate.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "buspirone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with captopril.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Phenelzine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with flunarizine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with scopolamine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Cariprazine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Propacetamol.", "severity": 2}
{"drug1": "procaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Bretylium.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "felbamate", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with duloxetine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Lornoxicam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with carbamazepine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Levobupivacaine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Lofexidine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Olopatadine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Tolcapone.", "severity": 2}
{"drug1": "temazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with imipramine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with clonazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Etidocaine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with topiramate.", "severity": 2}
{"drug1": "tetracaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with butamben.", "severity": 2}
{"drug1": "clozapine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with methyclothiazide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with paramethasone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nilvadipine.", "severity": 2}
{"drug1": "pergolide", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with vincristine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with salicylamide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Salsalate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with chlorprothixene.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Aripiprazole.", "severity": 2}
{"drug1": "Etomidate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with leflunomide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "alprostadil", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprostadil is combined with aspirin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Echothiophate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Pirlindole.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Toloxatone.", "severity": 2}
{"drug1": "Clodronic Acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clodronic Acid is combined with Deferasirox.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Olopatadine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with dipyridamole.", "severity": 2}
{"drug1": "diflunisal", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with haloperidol.", "severity": 2}
{"drug1": "etizolam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Difenoxin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with norfloxacin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with oxymorphone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with gabapentin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Tolcapone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with amitriptyline.", "severity": 2}
{"drug1": "etizolam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with imipramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Levobupivacaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "midazolam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with clonidine.", "severity": 2}
{"drug1": "valsartan", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with felodipine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosamprenavir is combined with meperidine.", "severity": 2}
{"drug1": "etizolam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with loratadine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with epirizole.", "severity": 2}
{"drug1": "captopril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with mefenamic acid.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Olopatadine.", "severity": 2}
{"drug1": "captopril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with NAPROXEN.", "severity": 2}
{"drug1": "nystatin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Lercanidipine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with CYCLIZINE.", "severity": 2}
{"drug1": "halothane", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "halothane", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with flunitrazepam.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with dantrolene.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Estrone sulfate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with clidinium.", "severity": 2}
{"drug1": "propantheline", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ramipril.", "severity": 2}
{"drug1": "fenbufen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Propacetamol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with meclizine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "estazolam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Remoxipride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with valsartan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ketorolac.", "severity": 2}
{"drug1": "propofol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with metolazone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nabumetone.", "severity": 2}
{"drug1": "Metixene", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Tapentadol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with ritodrine.", "severity": 2}
{"drug1": "carboprost trometamol", "drug2": "Prostaglandin E2", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboprost trometamol is combined with Prostaglandin E2.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ramipril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with chloroquine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tenoxicam.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with methscopolamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with doxepin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with nitroglycerin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with chlorprothixene.", "severity": 2}
{"drug1": "amisulpride", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with carisoprodol.", "severity": 2}
{"drug1": "amisulpride", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with sulpiride.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with clenbuterol.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with nitroglycerin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with procaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with carisoprodol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with levodopa.", "severity": 2}
{"drug1": "maprotiline", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with metoclopramide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with pimozide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with meclizine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with niflumic acid.", "severity": 2}
{"drug1": "zopiclone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with levodopa.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with mesalamine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with levodopa.", "severity": 2}
{"drug1": "carboprost trometamol", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboprost trometamol is combined with misoprostol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Bretylium.", "severity": 2}
{"drug1": "propofol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with cilazapril.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with methazolamide.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Pizotifen.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with amitriptyline.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Tolcapone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Agomelatine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with clenbuterol.", "severity": 2}
{"drug1": "benazepril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with azelastine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with theobromine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Mirabegron.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Retigabine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with pilocarpine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Metipranolol.", "severity": 2}
{"drug1": "temazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Asenapine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Pomalidomide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "codeine", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Potassium citrate.", "severity": 2}
{"drug1": "indapamide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with terazosin.", "severity": 2}
{"drug1": "dapsone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with butalbital.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with olanzapine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with medrysone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with methadone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Difenoxin.", "severity": 2}
{"drug1": "sulindac", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with prednisone.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with tubocurarine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with propoxyphene.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with dyclonine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "enflurane", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Aceprometazine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Aripiprazole.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Agomelatine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with mesoridazine.", "severity": 2}
{"drug1": "losartan", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Milnacipran.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with methazolamide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with maprotiline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with butalbital.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Gemifloxacin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with SUFENTANIL.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with venlafaxine.", "severity": 2}
{"drug1": "etodolac", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with alclofenac.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with lidocaine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with clemastine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with sertraline.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Fencamfamin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Metixene.", "severity": 2}
{"drug1": "dyclonine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with methoxyflurane.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with fexofenadine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with methocarbamol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nevirapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with nevirapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with triprolidine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with quetiapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Perospirone.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with citalopram.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Ephedrine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "quinidine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with levorphanol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with quetiapine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EDOXABAN is combined with meperidine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Cariprazine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with flunarizine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Fluspirilene.", "severity": 2}
{"drug1": "procyclidine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with tolterodine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Apremilast", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with loteprednol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with SERTINDOLE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Echothiophate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with duloxetine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with diclofenac.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "miconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with isradipine.", "severity": 2}
{"drug1": "eperisone", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with pravastatin.", "severity": 2}
{"drug1": "sotalol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ondansetron.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with tiagabine.", "severity": 2}
{"drug1": "sotalol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with zonisamide.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with DEZOCINE.", "severity": 2}
{"drug1": "baclofen", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with tizanidine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with prazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Flibanserin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with oxprenolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "meclizine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Pipotiazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with sparfloxacin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with oxprenolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Paliperidone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with antipyrine.", "severity": 2}
{"drug1": "pimozide", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with methoxyflurane.", "severity": 2}
{"drug1": "benzocaine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with prilocaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with fosinopril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with doxepin.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with GUANFACINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with levorphanol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with tizanidine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with methocarbamol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "prazosin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with benazepril.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Difenoxin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with amoxapine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with nortriptyline.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Fesoterodine.", "severity": 2}
{"drug1": "baclofen", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with cetirizine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with tiagabine.", "severity": 2}
{"drug1": "baclofen", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with protriptyline.", "severity": 2}
{"drug1": "furosemide", "drug2": "Arbekacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Arbekacin.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with zonisamide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with citalopram.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with nilvadipine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with procarbazine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with ramipril.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ximelagatran is combined with meperidine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with cilazapril.", "severity": 2}
{"drug1": "Butethal", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with etizolam.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with duloxetine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with fluoxetine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with terazosin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Estrone sulfate.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Cyamemazine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with promethazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Iloperidone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with fludrocortisone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with flumethasone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Trabectedin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Trabectedin.", "severity": 2}
{"drug1": "enalapril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with meperidine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Pimecrolimus.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with topiramate.", "severity": 2}
{"drug1": "Butethal", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with KETAZOLAM.", "severity": 2}
{"drug1": "scopolamine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with clonazepam.", "severity": 2}
{"drug1": "scopolamine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with promethazine.", "severity": 2}
{"drug1": "topiramate", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with tiapride.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with metoclopramide.", "severity": 2}
{"drug1": "aspirin", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with difluprednate.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with ADAPALENE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with topiramate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Varenicline.", "severity": 2}
{"drug1": "thiothixene", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with enflurane.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with tubocurarine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with thiothixene.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Thioproperazine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Pipotiazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Articaine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Tolcapone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with amitriptyline.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with METAXALONE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "baclofen", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "baclofen", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with flunarizine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with flurandrenolide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ramipril.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with meclofenamic acid.", "severity": 2}
{"drug1": "lorazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with flunarizine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "nicardipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with methazolamide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Lormetazepam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with DEZOCINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Fluspirilene.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with diltiazem.", "severity": 2}
{"drug1": "trazodone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "zopiclone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with methocarbamol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with etizolam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with triprolidine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with doxorubicin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with haloperidol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with fexofenadine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with scopolamine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with ketamine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with quetiapine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with zotepine.", "severity": 2}
{"drug1": "methadone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with protriptyline.", "severity": 2}
{"drug1": "imipramine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Difenoxin.", "severity": 2}
{"drug1": "methadone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with cetirizine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "cocaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with clidinium.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with thiamylal.", "severity": 2}
{"drug1": "methadone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with glutethimide.", "severity": 2}
{"drug1": "pimozide", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Mephobarbital.", "severity": 2}
{"drug1": "procarbazine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with risperidone.", "severity": 2}
{"drug1": "methadone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "procarbazine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with leflunomide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "morphine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Paliperidone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with paramethasone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with physostigmine.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with barnidipine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methadone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Clevidipine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with rivastigmine.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Escitalopram.", "severity": 2}
{"drug1": "Spirapril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with floctafenine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with alprazolam.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Pefloxacin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with nisoldipine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with loxapine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Remoxipride.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Mometasone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with terazosin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with imipramine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Lercanidipine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with hydrocortisone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with metolazone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with nortriptyline.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with prazosin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with zotepine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with propranolol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with imipramine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Iloperidone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "sotalol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Fluprednidene.", "severity": 2}
{"drug1": "Naftifine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with penbutolol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with tizanidine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Clobetasone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Eplerenone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with nimesulide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with metaproterenol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Asenapine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Pizotifen.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with clidinium.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Gemifloxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with tenoxicam.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with nabumetone.", "severity": 2}
{"drug1": "reserpine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with desipramine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with clonidine.", "severity": 2}
{"drug1": "reserpine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with thiamylal.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Amrinone.", "severity": 2}
{"drug1": "promethazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Aceprometazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Bortezomib.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "resveratrol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "quinapril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with chloroquine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Fluprednidene.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with amisulpride.", "severity": 2}
{"drug1": "quinapril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with sulindac.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Empagliflozin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with rasagiline.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Salmeterol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with maprotiline.", "severity": 2}
{"drug1": "antipyrine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with epirizole.", "severity": 2}
{"drug1": "promazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with METAXALONE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with enalapril.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Desloratadine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with hydromorphone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with NICORANDIL.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Azelnidipine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Benidipine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with cilnidipine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Efonidipine.", "severity": 2}
{"drug1": "procaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Aliskiren.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with HEROIN.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with acetylcholine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with meprobamate.", "severity": 2}
{"drug1": "estazolam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Perospirone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with zonisamide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Risedronic acid.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Clevidipine.", "severity": 2}
{"drug1": "methysergide", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with KETAZOLAM.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Cis-mdp.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with amcinonide.", "severity": 2}
{"drug1": "clidinium", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with doxepin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Fencamfamin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with furosemide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nitric oxide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with procaine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with atenolol.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with acemetacin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Retigabine.", "severity": 2}
{"drug1": "diazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "diazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with amoxapine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with tizanidine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Clevidipine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with quinapril.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with bumetanide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with HEROIN.", "severity": 2}
{"drug1": "minoxidil", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with promethazine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with chlorthalidone.", "severity": 2}
{"drug1": "levodopa", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Pirlindole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with acetaminophen.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with efavirenz.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with rescinnamine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Empagliflozin.", "severity": 2}
{"drug1": "midodrine", "drug2": "phenylephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with phenylephrine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with nalidixic acid.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Telmisartan.", "severity": 2}
{"drug1": "diflunisal", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with flumethasone.", "severity": 2}
{"drug1": "clonidine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with fexofenadine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with METAXALONE.", "severity": 2}
{"drug1": "dapsone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with nitroglycerin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Carbamylcholine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with malathion.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with methyldopa.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Clevidipine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "phenylephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with phenylephrine.", "severity": 2}
{"drug1": "carprofen", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with SERATRODAST.", "severity": 2}
{"drug1": "butalbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with levodopa.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Milnacipran.", "severity": 2}
{"drug1": "prilocaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with felbamate.", "severity": 2}
{"drug1": "clidinium", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with promethazine.", "severity": 2}
{"drug1": "clidinium", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with clonazepam.", "severity": 2}
{"drug1": "losartan", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with rescinnamine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "antipyrine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with halcinonide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ramipril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Sacubitril.", "severity": 2}
{"drug1": "levorphanol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with MOLINDONE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with METAXALONE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Aceprometazine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with secobarbital.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Pipamperone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Fospropofol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Pomalidomide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "losartan", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with enalapril.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with equilin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "Articaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with atorvastatin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Etidronic acid.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Deferasirox.", "severity": 2}
{"drug1": "procaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "procaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with lithium ion.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Difenoxin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with PROCATEROL.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with cinoxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Spirapril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "ethanol", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Fluspirilene.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with flunarizine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with galanthamine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with hydrocortisone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Isoflurophate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with vinblastine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with formestane.", "severity": 2}
{"drug1": "prazosin", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with AMILORIDE.", "severity": 2}
{"drug1": "morphine", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "morphine", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with polythiazide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with trazodone.", "severity": 2}
{"drug1": "azelastine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with epirizole.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Cyamemazine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with dipyridamole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Lurasidone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with periciazine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with alclometasone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Fospropofol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Canrenoic acid.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with paramethasone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with benazepril.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Eprosartan.", "severity": 2}
{"drug1": "benztropine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with topiramate.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "hexetidine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with manidipine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Nebivolol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with flunisolide.", "severity": 2}
{"drug1": "Articaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with Calcifediol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Flibanserin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with scopolamine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with suprofen.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with DEZOCINE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with niflumic acid.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with butalbital.", "severity": 2}
{"drug1": "thalidomide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with dipyridamole.", "severity": 2}
{"drug1": "HEROIN", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with theobromine.", "severity": 2}
{"drug1": "codeine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with diazepam.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with tiagabine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Pirlindole.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with triflupromazine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with haloperidol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with zonisamide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Risedronic acid.", "severity": 2}
{"drug1": "Etomidate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with GUANFACINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with quazepam.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with prazepam.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Propacetamol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with nisoldipine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with AMILORIDE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with thiamylal.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pargyline", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with droxidopa.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with mefenamic acid.", "severity": 2}
{"drug1": "Icatibant", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with equilin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Fluprednidene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nitrazepam.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Levetiracetam.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with primidone.", "severity": 2}
{"drug1": "meperidine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with bromocriptine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with pimozide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with loratadine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with nitrous oxide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with vincristine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with methyclothiazide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with amoxapine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Efonidipine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Fospropofol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with zafirlukast.", "severity": 2}
{"drug1": "tiapride", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with clomipramine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "sertraline", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with MELPERONE.", "severity": 2}
{"drug1": "sertraline", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with zotepine.", "severity": 2}
{"drug1": "triamterene", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with isoproterenol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with furosemide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with tizanidine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Iloperidone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with irinotecan.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with methimazole.", "severity": 2}
{"drug1": "amoxapine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with clonazepam.", "severity": 2}
{"drug1": "amoxapine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with promethazine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with valsartan.", "severity": 2}
{"drug1": "Nabilone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with AMILORIDE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with lovastatin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with diflorasone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with nitroglycerin.", "severity": 2}
{"drug1": "loxapine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with felbamate.", "severity": 2}
{"drug1": "codeine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with tiagabine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with felbamate.", "severity": 2}
{"drug1": "risperidone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with glutethimide.", "severity": 2}
{"drug1": "pancuronium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with levorphanol.", "severity": 2}
{"drug1": "azelastine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with haloperidol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Difenoxin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with clozapine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with vinorelbine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Cis-mdp.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with betamethasone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with diflorasone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Propoxycaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Pramocaine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with atorvastatin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with etizolam.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Lercanidipine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with desipramine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with nitroglycerin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with flurandrenolide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with lisinopril.", "severity": 2}
{"drug1": "Naftifine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with flunisolide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with amitriptyline.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Iloperidone.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with manidipine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Riociguat.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Fluprednidene.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with bromocriptine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with fosinopril.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Flibanserin.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with triprolidine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with sotalol.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "timolol", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with sotalol.", "severity": 2}
{"drug1": "aspirin", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with formestane.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with testosterone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with memantine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with brimonidine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Nabilone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with baclofen.", "severity": 2}
{"drug1": "morniflumate", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with suprofen.", "severity": 2}
{"drug1": "Asenapine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with chlormezanone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with cilazapril.", "severity": 2}
{"drug1": "Asenapine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "sulindac", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with etodolac.", "severity": 2}
{"drug1": "ramipril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with bumetanide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with clonidine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Ropivacaine.", "severity": 2}
{"drug1": "benazepril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "risperidone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with METAXALONE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with fenoprofen.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nitric oxide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with cetirizine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with METAXALONE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with protriptyline.", "severity": 2}
{"drug1": "codeine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Levocetirizine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with desipramine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Deferasirox.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with fexofenadine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with thiamylal.", "severity": 2}
{"drug1": "codeine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with amisulpride.", "severity": 2}
{"drug1": "alprazolam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with codeine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with furazolidone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Estrone sulfate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with halothane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with butorphanol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "formestane", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with enalapril.", "severity": 2}
{"drug1": "Amrinone", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with simvastatin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Ramelteon.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with ethosuximide.", "severity": 2}
{"drug1": "topiramate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Levetiracetam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with fludiazepam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with niflumic acid.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with metoclopramide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Olopatadine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Lormetazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with thiopental.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Fluspirilene.", "severity": 2}
{"drug1": "diltiazem", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with methazolamide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with ethosuximide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with NITROUS ACID.", "severity": 2}
{"drug1": "butorphanol", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with desipramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with isoxsuprine.", "severity": 2}
{"drug1": "meperidine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with flunitrazepam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with brotizolam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Teriflunomide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Riociguat.", "severity": 2}
{"drug1": "protriptyline", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with terbutaline.", "severity": 2}
{"drug1": "thiamylal", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with venlafaxine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with prednisone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with clemastine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with antipyrine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with efavirenz.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Desloratadine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Telmisartan.", "severity": 2}
{"drug1": "ipratropium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "halothane", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Eprosartan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with zaleplon.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with mepivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulindac", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with diflorasone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with tenoxicam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ketorolac.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with chlormezanone.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with doxepin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with GUANFACINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with carvedilol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Etomidate.", "severity": 2}
{"drug1": "pergolide", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Tadalafil.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "carmustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with carmustine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with nilvadipine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with nitrazepam.", "severity": 2}
{"drug1": "amcinonide", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with ambenonium.", "severity": 2}
{"drug1": "midazolam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Asenapine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "captopril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Pregabalin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with Dothiepin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with mycophenolic acid.", "severity": 2}
{"drug1": "etizolam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Levetiracetam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with bromazepam.", "severity": 2}
{"drug1": "sertraline", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Fluspirilene.", "severity": 2}
{"drug1": "butabarbital", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Tixocortol.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Olopatadine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with thioridazine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "trandolapril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with sulfasalazine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with acemetacin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Nitroprusside.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with glutethimide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "bromazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with thiothixene.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "butenafine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Clevidipine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Cariprazine.", "severity": 2}
{"drug1": "Trospium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with captopril.", "severity": 2}
{"drug1": "zotepine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with ethotoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Pipotiazine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with oxprenolol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with KETAZOLAM.", "severity": 2}
{"drug1": "clozapine", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with meprobamate.", "severity": 2}
{"drug1": "triprolidine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with duloxetine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with prazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with quazepam.", "severity": 2}
{"drug1": "procarbazine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with isoproterenol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Pipamperone.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Pizotifen.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Flupentixol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Trovafloxacin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Lormetazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with theobromine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with methoxyflurane.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with perphenazine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with venlafaxine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with ondansetron.", "severity": 2}
{"drug1": "doxepin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with citalopram.", "severity": 2}
{"drug1": "proparacaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with tiagabine.", "severity": 2}
{"drug1": "pergolide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with irbesartan.", "severity": 2}
{"drug1": "buspirone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with clonidine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with lomustine.", "severity": 2}
{"drug1": "pergolide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with felodipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Pipamperone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with METAXALONE.", "severity": 2}
{"drug1": "isradipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Clevidipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "sotalol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with metolazone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with antipyrine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with flunarizine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with baclofen.", "severity": 2}
{"drug1": "epinephrine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with atorvastatin.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Fencamfamin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with loteprednol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with suprofen.", "severity": 2}
{"drug1": "loxapine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Pizotifen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Teriflunomide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with DESONIDE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with midazolam.", "severity": 2}
{"drug1": "estazolam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with clomipramine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Milnacipran.", "severity": 2}
{"drug1": "Salsalate", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with homoharringtonine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with salicylamide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Olopatadine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Tixocortol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nisoldipine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with mitoxantrone.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with nylidrin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with chlorzoxazone.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "procaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with felbamate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with paramethasone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Milnacipran.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "selegiline", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with clomipramine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Metipranolol.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Efonidipine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with Paricalcitol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with nifedipine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with resveratrol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with levorphanol.", "severity": 2}
{"drug1": "cerulenin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "estazolam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with prilocaine.", "severity": 2}
{"drug1": "sotalol", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with acebutolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with tenoxicam.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with felbamate.", "severity": 2}
{"drug1": "estazolam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with tranylcypromine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with clonidine.", "severity": 2}
{"drug1": "Butethal", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with prazepam.", "severity": 2}
{"drug1": "prazosin", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with losartan.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Demecarium.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with clidinium.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Riociguat.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with flunisolide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Milnacipran.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Milnacipran.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with medrysone.", "severity": 2}
{"drug1": "propofol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with clidinium.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with triprolidine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with fenbufen.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with spironolactone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Carbetocin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with trimipramine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with carvedilol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with butalbital.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with fenbufen.", "severity": 2}
{"drug1": "risperidone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with tiagabine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with cabergoline.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Tasimelteon.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with chlorzoxazone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with trifluoperazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Ketobemidone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with methazolamide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with estazolam.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with lovastatin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with cetirizine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with betamethasone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with protriptyline.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with bumetanide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Butethal.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with chlorothiazide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with quinapril.", "severity": 2}
{"drug1": "clonazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with olanzapine.", "severity": 2}
{"drug1": "reserpine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with doxazosin.", "severity": 2}
{"drug1": "ketamine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with butamben.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with chlorpheniramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with AMILORIDE.", "severity": 2}
{"drug1": "reserpine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with thiopental.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with nitrazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with flunarizine.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with nimodipine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with desipramine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Aceprometazine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with epirizole.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with MOLINDONE.", "severity": 2}
{"drug1": "butamben", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Lormetazepam.", "severity": 2}
{"drug1": "phentolamine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with methyclothiazide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with triprolidine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with methocarbamol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with spironolactone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with doxepin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with loratadine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with tubocurarine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with flurandrenolide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with dantrolene.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with xylometazoline.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with tolfenamic acid.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Torasemide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with carvedilol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with estrone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Normethadone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with cyclothiazide.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with propranolol.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with clonidine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with fluocinonide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Cevimeline.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with lidocaine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with propantheline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with polythiazide.", "severity": 2}
{"drug1": "quinapril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Salsalate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with risperidone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with meclizine.", "severity": 2}
{"drug1": "propofol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with nitrazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Halazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with proparacaine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with procaine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with MOLINDONE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with trimipramine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with isradipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Clevidipine.", "severity": 2}
{"drug1": "felbamate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with doxepin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Aceprometazine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with bumetanide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with olanzapine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with methadone.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with cilazapril.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with salicylamide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with zonisamide.", "severity": 2}
{"drug1": "thiopental", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with procaine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with isoxsuprine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Iloperidone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Pipotiazine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with tiagabine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with thiothixene.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Thioproperazine.", "severity": 2}
{"drug1": "etodolac", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with homoharringtonine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with sertraline.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Desloratadine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Nitroprusside.", "severity": 2}
{"drug1": "halothane", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nisoldipine.", "severity": 2}
{"drug1": "halothane", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Aceprometazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with butamben.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Metipranolol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "equilin", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Echothiophate.", "severity": 2}
{"drug1": "clonazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Aliskiren.", "severity": 2}
{"drug1": "nicergoline", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with oxymetholone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Retigabine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Flibanserin.", "severity": 2}
{"drug1": "prazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with ethotoin.", "severity": 2}
{"drug1": "Propiverine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with nalbuphine.", "severity": 2}
{"drug1": "argatroban", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with salicylic acid.", "severity": 2}
{"drug1": "clozapine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with tiagabine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with methyclothiazide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with amisulpride.", "severity": 2}
{"drug1": "miconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with nifedipine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Ramelteon.", "severity": 2}
{"drug1": "sotalol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Metipranolol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Fluspirilene.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with flunarizine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with thiamylal.", "severity": 2}
{"drug1": "Torasemide", "drug2": "allopurinol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with allopurinol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "methenamine", "drug2": "sulfadiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methenamine is combined with sulfadiazine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "ethotoin", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "pramipexole", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with bumetanide.", "severity": 2}
{"drug1": "temazepam", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with promazine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with cilazapril.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Perospirone.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with cilazapril.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with duloxetine.", "severity": 2}
{"drug1": "midodrine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "thioguanine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with thioguanine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with fluoxetine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Olopatadine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Pramocaine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Aceprometazine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with tizanidine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with CYCLIZINE.", "severity": 2}
{"drug1": "butamben", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with scopolamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with HEROIN.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with rasagiline.", "severity": 2}
{"drug1": "meperidine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with promethazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with clonazepam.", "severity": 2}
{"drug1": "atenolol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with spironolactone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Canagliflozin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with quazepam.", "severity": 2}
{"drug1": "topiramate", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Tolcapone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with diphenhydramine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with thiopental.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BOPINDOLOL is combined with acetylcholine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with digoxin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with sulpiride.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with chlormezanone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with CYCLIZINE.", "severity": 2}
{"drug1": "benazepril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with leflunomide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with orphenadrine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with PERHEXILINE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with edrophonium.", "severity": 2}
{"drug1": "etoposide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etoposide is combined with leflunomide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with clidinium.", "severity": 2}
{"drug1": "HEROIN", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with methazolamide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Eplerenone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with cetirizine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "5-azacytidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with 5-azacytidine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with pentazocine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Pinaverium.", "severity": 2}
{"drug1": "morphine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with phentolamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Lacidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with flurazepam.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Demecarium.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Aceprometazine.", "severity": 2}
{"drug1": "morphine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with furosemide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with sotalol.", "severity": 2}
{"drug1": "Butethal", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with baclofen.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with etizolam.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with AMILORIDE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ethosuximide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with methazolamide.", "severity": 2}
{"drug1": "temazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with apraclonidine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with docetaxel.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with desipramine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with isocarboxazid.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "allopurinol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with allopurinol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with gemfibrozil.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with halothane.", "severity": 2}
{"drug1": "furosemide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with methyldopa.", "severity": 2}
{"drug1": "furazolidone", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with HYDROCODONE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with tetracaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with sotalol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with butalbital.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "furosemide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with apraclonidine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Telmisartan.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with diazepam.", "severity": 2}
{"drug1": "nimesulide", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Lurasidone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Normethadone.", "severity": 2}
{"drug1": "zotepine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with proparacaine.", "severity": 2}
{"drug1": "isradipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with bumetanide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Halazepam.", "severity": 2}
{"drug1": "malathion", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when malathion is combined with methacholine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with efavirenz.", "severity": 2}
{"drug1": "isradipine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with quinapril.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with terazosin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with homoharringtonine.", "severity": 2}
{"drug1": "isradipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "carprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with alclometasone.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with terazosin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with paroxetine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with pancuronium.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with flurazepam.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Vecuronium.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with meclizine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with tiapride.", "severity": 2}
{"drug1": "docetaxel", "drug2": "retinol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with retinol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with methylprednisolone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with eperisone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "moxifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with moxifloxacin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Vilanterol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Tolcapone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with isoflurane.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with topiramate.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with ethotoin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with atorvastatin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "furosemide", "drug2": "Valrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Valrubicin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with citalopram.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "sulindac", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Fencamfamin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with pancuronium.", "severity": 2}
{"drug1": "bepridil", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with trifluoperazine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Levocetirizine.", "severity": 2}
{"drug1": "reserpine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with tiagabine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with efavirenz.", "severity": 2}
{"drug1": "reserpine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ondansetron.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Teriflunomide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with resveratrol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with butamben.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with mepivacaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with zaleplon.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nicotinamide.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with nilvadipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with carvedilol.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Pramocaine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with trandolapril.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with prednisone.", "severity": 2}
{"drug1": "aspirin", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Etoricoxib.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Enalaprilat.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "methadone", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with periciazine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Lacidipine.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfisoxazole is combined with atorvastatin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with clidinium.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Levocetirizine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with methylprednisolone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Perospirone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with brimonidine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Salsalate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with pimozide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with chlorthalidone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with tamoxifen.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with thioridazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with losartan.", "severity": 2}
{"drug1": "resveratrol", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with methylprednisolone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with clidinium.", "severity": 2}
{"drug1": "fosinopril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with tenoxicam.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Olmesartan.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with topiramate.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Salmeterol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with isradipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with nabumetone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ketorolac.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with MELPERONE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with zotepine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Levetiracetam.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with fexofenadine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with DEZOCINE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with droperidol.", "severity": 2}
{"drug1": "amifostine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with clozapine.", "severity": 2}
{"drug1": "aspirin", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with furosemide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Normethadone.", "severity": 2}
{"drug1": "halothane", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with cetirizine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Flupentixol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with trandolapril.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with rapamycin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Eprosartan.", "severity": 2}
{"drug1": "donepezil", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when donepezil is combined with Cevimeline.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with furazolidone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with furosemide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Metipranolol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "topiramate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Flibanserin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with citalopram.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with equilin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with meclizine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with chloral hydrate.", "severity": 2}
{"drug1": "codeine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with amobarbital.", "severity": 2}
{"drug1": "nefazodone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with atorvastatin.", "severity": 2}
{"drug1": "dapsone", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with Olsalazine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Remoxipride.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with Pitavastatin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Talniflumate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Talniflumate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "butabarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with butabarbital.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Normethadone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "temazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with temazepam.", "severity": 2}
{"drug1": "thalidomide", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with diltiazem.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Topiroxostat.", "severity": 2}
{"drug1": "Melatonin", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with chlorzoxazone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Propiverine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with meperidine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomepromazine is combined with Milnacipran.", "severity": 2}
{"drug1": "Butethal", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with vigabatrin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with timolol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Canagliflozin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with bupivacaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Ropivacaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with morphine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with miconazole.", "severity": 2}
{"drug1": "Asenapine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with mepivacaine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Desloratadine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "ropinirole", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with methyldopa.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with nicardipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with hydralazine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with physostigmine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with thiothixene.", "severity": 2}
{"drug1": "temazepam", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with clorazepate.", "severity": 2}
{"drug1": "amcinonide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with rivastigmine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "losartan", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with sulfasalazine.", "severity": 2}
{"drug1": "losartan", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "losartan", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with reserpine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with cinoxacin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with propranolol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Pramocaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Propoxycaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Levetiracetam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with acetazolamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with DEZOCINE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with methylprednisolone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with dantrolene.", "severity": 2}
{"drug1": "methadone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "promethazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with flunarizine.", "severity": 2}
{"drug1": "sotalol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with quetiapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with selegiline.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with topiramate.", "severity": 2}
{"drug1": "loxapine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with imipramine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Desloratadine.", "severity": 2}
{"drug1": "quinidine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with butorphanol.", "severity": 2}
{"drug1": "halothane", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "captopril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Lornoxicam.", "severity": 2}
{"drug1": "loxapine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with meperidine.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fondaparinux is combined with Deferasirox.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with salicylic acid.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with GUANFACINE.", "severity": 2}
{"drug1": "sulindac", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with meclofenamic acid.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Lornoxicam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with nadolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with oxaprozin.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with butalbital.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Olopatadine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with nortriptyline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with amoxapine.", "severity": 2}
{"drug1": "citalopram", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with isocarboxazid.", "severity": 2}
{"drug1": "ethotoin", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with vigabatrin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with amoxapine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with nortriptyline.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with tiapride.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Empagliflozin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Olopatadine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Flibanserin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "tiagabine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with sertraline.", "severity": 2}
{"drug1": "periciazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when periciazine is combined with thiopental.", "severity": 2}
{"drug1": "clidinium", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with fexofenadine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Pomalidomide.", "severity": 2}
{"drug1": "reserpine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with captopril.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with diflorasone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Olopatadine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Levomilnacipran.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Fluprednidene.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Fencamfamin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with bromazepam.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Phenelzine.", "severity": 2}
{"drug1": "propofol", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ramipril.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Loxoprofen.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with prednisone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Lercanidipine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "nimodipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with simvastatin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "tiapride", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with amitriptyline.", "severity": 2}
{"drug1": "dopamine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "tiapride", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Tolcapone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Articaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with metolazone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Aceprometazine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with efavirenz.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with aspirin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with Echothiophate.", "severity": 2}
{"drug1": "procyclidine", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with dicyclomine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with norfloxacin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with lidocaine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with butorphanol.", "severity": 2}
{"drug1": "bepridil", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with losartan.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with cetirizine.", "severity": 2}
{"drug1": "Trospium", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with oxyphenonium.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Deferasirox.", "severity": 2}
{"drug1": "Nabilone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with selegiline.", "severity": 2}
{"drug1": "bromazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with protriptyline.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with chlorpheniramine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with antipyrine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with pravastatin.", "severity": 2}
{"drug1": "epirizole", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Tixocortol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with loratadine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with tiagabine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with zonisamide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with penbutolol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with imipramine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Pizotifen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with formestane.", "severity": 2}
{"drug1": "halothane", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with papaverine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with paroxetine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with nimesulide.", "severity": 2}
{"drug1": "halothane", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with chlorpheniramine.", "severity": 2}
{"drug1": "halothane", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nifedipine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Nitroprusside.", "severity": 2}
{"drug1": "Butethal", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Difenoxin.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "midazolam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with pimozide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with duloxetine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with orphenadrine.", "severity": 2}
{"drug1": "codeine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with doxepin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "sulconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with tizanidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Nebivolol.", "severity": 2}
{"drug1": "Trospium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Normethadone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "sulindac", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with homoharringtonine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Olmesartan.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with diazepam.", "severity": 2}
{"drug1": "protriptyline", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with isoetharine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with cetirizine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with protriptyline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with levodopa.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with chlorprothixene.", "severity": 2}
{"drug1": "pancuronium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "sertraline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with periciazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Olopatadine.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrofurantoin is combined with prilocaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with losartan.", "severity": 2}
{"drug1": "carprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Mometasone.", "severity": 2}
{"drug1": "morphine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with trandolapril.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with potassium ion.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with morphine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with tetracaine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Telmisartan.", "severity": 2}
{"drug1": "medrysone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with malathion.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Nabilone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with methazolamide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with PAMABROM.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Droxicam.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with tolterodine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Loxoprofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with quetiapine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with fenbufen.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with butalbital.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Mometasone.", "severity": 2}
{"drug1": "halothane", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with butalbital.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with carvedilol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Pomalidomide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with isradipine.", "severity": 2}
{"drug1": "tiapride", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Retigabine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Olmesartan.", "severity": 2}
{"drug1": "etodolac", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Levomilnacipran.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with mefloquine.", "severity": 2}
{"drug1": "baclofen", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Escitalopram.", "severity": 2}
{"drug1": "baclofen", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with CYCLIZINE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with furosemide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with citalopram.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with digitoxin.", "severity": 2}
{"drug1": "felbamate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with fexofenadine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with sulpiride.", "severity": 2}
{"drug1": "morniflumate", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with salicylic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Lercanidipine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with cyclophosphamide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with triazolam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "phenindione", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with phenindione.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with tolazoline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Nabilone", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with doxazosin.", "severity": 2}
{"drug1": "risperidone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "haloperidol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "loxapine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with tiapride.", "severity": 2}
{"drug1": "carprofen", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Aceclofenac.", "severity": 2}
{"drug1": "topiramate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with promethazine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Icatibant.", "severity": 2}
{"drug1": "fenbufen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with amcinonide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with lisinopril.", "severity": 2}
{"drug1": "desipramine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Cyamemazine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with dantrolene.", "severity": 2}
{"drug1": "diazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with clozapine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with isocarboxazid.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with phenytoin.", "severity": 2}
{"drug1": "morniflumate", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Clevidipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with NAPROXEN.", "severity": 2}
{"drug1": "benzocaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with loratadine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with prazosin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Mirabegron.", "severity": 2}
{"drug1": "enflurane", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with paroxetine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Sacubitril.", "severity": 2}
{"drug1": "butorphanol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with clomipramine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with fludiazepam.", "severity": 2}
{"drug1": "benzocaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with imipramine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with fosinopril.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Rotigotine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with tetracaine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Indacaterol.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Ciclesonide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Naftifine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Articaine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with carvedilol.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Pizotifen.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Fluspirilene.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with flunarizine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with antipyrine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with nicardipine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with clonidine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Trospium", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Pentolinium.", "severity": 2}
{"drug1": "loxapine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with oxymorphone.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "halothane", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with maprotiline.", "severity": 2}
{"drug1": "reserpine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with methocarbamol.", "severity": 2}
{"drug1": "loxapine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with zopiclone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with propranolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with methylphenidate.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with SERATRODAST.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with zaltoprofen.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Aceclofenac.", "severity": 2}
{"drug1": "enflurane", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with DEZOCINE.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with methazolamide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with carprofen.", "severity": 2}
{"drug1": "Tramadol", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with levorphanol.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with ramipril.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Masoprocol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with desoximetasone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "5-Fluorouracil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "pargyline", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with dobutamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Perospirone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with vincristine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with penbutolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Butethal.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with lithium ion.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "loxapine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "medrysone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with mefloquine.", "severity": 2}
{"drug1": "etodolac", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with acemetacin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spiramycin is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Levocetirizine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Vecuronium.", "severity": 2}
{"drug1": "azelastine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with SERATRODAST.", "severity": 2}
{"drug1": "dyclonine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with imipramine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with loratadine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Aceclofenac.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with SERATRODAST.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with pancuronium.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "morphine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with tiagabine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with resveratrol.", "severity": 2}
{"drug1": "morphine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ondansetron.", "severity": 2}
{"drug1": "haloprogin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with nitrendipine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with resveratrol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Retigabine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Halazepam.", "severity": 2}
{"drug1": "isradipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with furosemide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with chlorthalidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "isradipine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "ibudilast", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "epirizole", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "epirizole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Risedronic acid.", "severity": 2}
{"drug1": "memantine", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when memantine is combined with nicotine.", "severity": 2}
{"drug1": "methysergide", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "diclofenac", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with methylprednisolone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with galanthamine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with thiothixene.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Pipotiazine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with bumetanide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with Isoflurophate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with nadolol.", "severity": 2}
{"drug1": "Limaprost", "drug2": "ticlopidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with ticlopidine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "midazolam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with proparacaine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with zotepine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with primidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with ALFENTANIL.", "severity": 2}
{"drug1": "etizolam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Desloratadine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Halazepam.", "severity": 2}
{"drug1": "morniflumate", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with D-mannitol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with butalbital.", "severity": 2}
{"drug1": "doxepin", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with topiramate.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with METAXALONE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiopental", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with ondansetron.", "severity": 2}
{"drug1": "thiopental", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with cocaine.", "severity": 2}
{"drug1": "thiopental", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with tiagabine.", "severity": 2}
{"drug1": "linezolid", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with MELPERONE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with ethosuximide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with zotepine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "thiopental", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with zonisamide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with AMILORIDE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Pramocaine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "retinol", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when retinol is combined with tretinoin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Propoxycaine.", "severity": 2}
{"drug1": "topiramate", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with duloxetine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Articaine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Tolcapone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with betaxolol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with salicylic acid.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with zaleplon.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with fenbufen.", "severity": 2}
{"drug1": "ketamine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with tetracaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Desloratadine.", "severity": 2}
{"drug1": "triazolam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with diphenhydramine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Masoprocol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with methocarbamol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with triprolidine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with acebutolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with primidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with tolazoline.", "severity": 2}
{"drug1": "quazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Bretylium.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with ethosuximide.", "severity": 2}
{"drug1": "bifonazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with nitrendipine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Oxetacaine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with zaltoprofen.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Aceclofenac.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with SERATRODAST.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Mirabegron.", "severity": 2}
{"drug1": "phentolamine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with ropinirole.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with DEZOCINE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with benzocaine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Salsalate.", "severity": 2}
{"drug1": "clozapine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with mecamylamine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with fludrocortisone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with oxycodone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with buspirone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Clobetasone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with zotepine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with MELPERONE.", "severity": 2}
{"drug1": "nystatin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Pregabalin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with terazosin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Flibanserin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Almotriptan.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Icatibant.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with butalbital.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Cis-mdp.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with irbesartan.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with nilvadipine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with clemastine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with Demecarium.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with felodipine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with triamterene.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with suprofen.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with butalbital.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with selegiline.", "severity": 2}
{"drug1": "ketorolac", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with budesonide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Milnacipran.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Pirlindole.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with diltiazem.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Lumiracoxib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with etizolam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Riociguat.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with terazosin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with butamben.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Nitroprusside.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Tolcapone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "cytarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with cytarabine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with betamethasone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with morphine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Lornoxicam.", "severity": 2}
{"drug1": "protriptyline", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with triprolidine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with clidinium.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with dobutamine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with atenolol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "reserpine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with trazodone.", "severity": 2}
{"drug1": "reserpine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with mecamylamine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with dichlorphenamide.", "severity": 2}
{"drug1": "reserpine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with pentazocine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "nadolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with hydralazine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "propafenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with propafenone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "cetirizine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "levodopa", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Tasimelteon.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with MOXONIDINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with GUANFACINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with ondansetron.", "severity": 2}
{"drug1": "nicergoline", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with vinblastine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with edrophonium.", "severity": 2}
{"drug1": "rasagiline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with moclobemide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with acetazolamide.", "severity": 2}
{"drug1": "buspirone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Etidocaine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with morphine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Salsalate.", "severity": 2}
{"drug1": "paramethasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "diltiazem", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with apraclonidine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Telmisartan.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Pizotifen.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Pipamperone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "PONATINIB", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with PONATINIB.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Doxercalciferol is combined with ergocalciferol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with benzocaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with formestane.", "severity": 2}
{"drug1": "methadone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Flupentixol.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with resveratrol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with topiramate.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with zolmitriptan.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Lornoxicam.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Levetiracetam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Remoxipride.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with hyoscyamine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with DEZOCINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Tasimelteon.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with lisinopril.", "severity": 2}
{"drug1": "THYMOL", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with tolfenamic acid.", "severity": 2}
{"drug1": "thioridazine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with D-mannitol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "alclofenac", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with budesonide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nicardipine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with clidinium.", "severity": 2}
{"drug1": "barnidipine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with penbutolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with decamethonium.", "severity": 2}
{"drug1": "trazodone", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Cyamemazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with clomipramine.", "severity": 2}
{"drug1": "biperiden", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "bumetanide", "drug2": "netilmicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with netilmicin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Vilazodone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Drospirenone.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Pizotifen.", "severity": 2}
{"drug1": "meperidine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with topiramate.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Pinaverium.", "severity": 2}
{"drug1": "felbamate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with imipramine.", "severity": 2}
{"drug1": "morphine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with butalbital.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Halazepam.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Etidronic acid.", "severity": 2}
{"drug1": "furosemide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with nifedipine.", "severity": 2}
{"drug1": "butamben", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with primidone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with diltiazem.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Phenelzine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Levetiracetam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with scopolamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with protriptyline.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with ketamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with quetiapine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with tiagabine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with zonisamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with triamcinolone.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Tramadol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with nimesulide.", "severity": 2}
{"drug1": "suprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Rotigotine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with felodipine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with loratadine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Salsalate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with irbesartan.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with isoxsuprine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Bretylium.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Lornoxicam.", "severity": 2}
{"drug1": "selegiline", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Pipamperone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with apraclonidine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with mesoridazine.", "severity": 2}
{"drug1": "ALENDRONIC ACID", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALENDRONIC ACID is combined with Deferasirox.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with citalopram.", "severity": 2}
{"drug1": "enflurane", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Olopatadine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Lormetazepam.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with fleroxacin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with clonazepam.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Bretylium.", "severity": 2}
{"drug1": "cocaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with lidocaine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Difenoxin.", "severity": 2}
{"drug1": "imipramine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with scopolamine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Fospropofol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with butamben.", "severity": 2}
{"drug1": "imipramine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with D-mannitol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Ramelteon.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Mometasone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with terazosin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ILOPROST.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "prazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with topiramate.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SIMEPREVIR is combined with meperidine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with mycophenolic acid.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with gabapentin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Indacaterol.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with tubocurarine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Sacubitril.", "severity": 2}
{"drug1": "levorphanol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with primidone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Cariprazine.", "severity": 2}
{"drug1": "pargyline", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with methadone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with equilin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with ketoprofen.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Melatonin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with KETAZOLAM.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with quazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with prazepam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with trimipramine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amprenavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "enalapril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with antipyrine.", "severity": 2}
{"drug1": "imipramine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with morphine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with prazepam.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "enalapril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with quetiapine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with indomethacin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with carvedilol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with loratadine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with CARTEOLOL.", "severity": 2}
{"drug1": "thalidomide", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with metolazone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with imipramine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Tolcapone.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with morphine.", "severity": 2}
{"drug1": "Articaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with vigabatrin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with loteprednol.", "severity": 2}
{"drug1": "sotalol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Nebivolol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with antipyrine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "quazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with olanzapine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with domperidone.", "severity": 2}
{"drug1": "quazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with clonazepam.", "severity": 2}
{"drug1": "ambenonium", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambenonium is combined with pilocarpine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Melatonin.", "severity": 2}
{"drug1": "zotepine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with butamben.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Asenapine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with scopolamine.", "severity": 2}
{"drug1": "furosemide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with quetiapine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Difenoxin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "amisulpride", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with mesoridazine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Empagliflozin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with mirtazapine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with clemastine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with venlafaxine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with fexofenadine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Fencamfamin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "pimozide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with clonidine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with isocarboxazid.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Propoxycaine.", "severity": 2}
{"drug1": "triamterene", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with quetiapine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Paliperidone.", "severity": 2}
{"drug1": "Articaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Flibanserin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Boceprevir is combined with meperidine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with amitriptyline.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Isoflurophate.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with thiamylal.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Udenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Udenafil.", "severity": 2}
{"drug1": "imipramine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with procarbazine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with halothane.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with betamethasone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with PERHEXILINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Canagliflozin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with irbesartan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Nabilone.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with dorzolamide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with sotalol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Oxetacaine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with MOLINDONE.", "severity": 2}
{"drug1": "THYMOL", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with eperisone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with tetracaine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Aceprometazine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Bretylium.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with sparfloxacin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "dibucaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with citalopram.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Flibanserin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with carisoprodol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "lidocaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with amoxapine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "lorazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Aceprometazine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Nitroprusside.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Tolcapone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Paliperidone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Flupentixol.", "severity": 2}
{"drug1": "tiapride", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with butamben.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with hydralazine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tadalafil is combined with atorvastatin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Lurasidone.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with eperisone.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with amcinonide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Regorafenib.", "severity": 2}
{"drug1": "salicylamide", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with flumethasone.", "severity": 2}
{"drug1": "morphine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with butorphanol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with lisinopril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with NAPROXEN.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with nimodipine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Nilotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Nilotinib.", "severity": 2}
{"drug1": "fosinopril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with mefenamic acid.", "severity": 2}
{"drug1": "meperidine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with metolazone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with carisoprodol.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Lercanidipine.", "severity": 2}
{"drug1": "aspirin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with propoxyphene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with dyclonine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Pomalidomide.", "severity": 2}
{"drug1": "cocaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with nimesulide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with ritonavir.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with oxymorphone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with penbutolol.", "severity": 2}
{"drug1": "terbinafine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with xylometazoline.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with trimipramine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with triflupromazine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with procaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Toloxatone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Pirlindole.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with promethazine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with fleroxacin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with enflurane.", "severity": 2}
{"drug1": "dibucaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with felbamate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Gemifloxacin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with promethazine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with simvastatin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Normethadone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with carisoprodol.", "severity": 2}
{"drug1": "naratriptan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with olanzapine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with etizolam.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with doxepin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with chloral hydrate.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Canagliflozin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with nefazodone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Etidocaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nicardipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with cyclothiazide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with minoxidil.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with efavirenz.", "severity": 2}
{"drug1": "clomipramine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with morphine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with thalidomide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Mometasone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with clonazepam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Fluprednidene.", "severity": 2}
{"drug1": "indomethacin", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Flupentixol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with cetirizine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with ethotoin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with tretinoin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with methazolamide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with topotecan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Eplerenone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with fexofenadine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "methysergide", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with antipyrine.", "severity": 2}
{"drug1": "ketamine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with prazepam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Difenoxin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with promethazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with clonazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Melatonin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with procarbazine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with cocaine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with scopolamine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with reserpine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with isoxsuprine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Carbamylcholine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with tiapride.", "severity": 2}
{"drug1": "codeine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with clonidine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with clonazepam.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with promethazine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with nitroglycerin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with dipyridamole.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with dantrolene.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Clevidipine.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoxsuprine is combined with Empagliflozin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with thiamylal.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Aliskiren.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "terconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with nifedipine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with ambenonium.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Tolvaptan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with chlormezanone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Asenapine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Flibanserin.", "severity": 2}
{"drug1": "temazepam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with bromazepam.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with thioridazine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with paramethasone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Nebivolol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Ciclesonide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Milnacipran.", "severity": 2}
{"drug1": "isoflurane", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Droxicam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with diphenhydramine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "propranolol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with butalbital.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with pentazocine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with maprotiline.", "severity": 2}
{"drug1": "tiapride", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with methylphenidate.", "severity": 2}
{"drug1": "tiapride", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with methocarbamol.", "severity": 2}
{"drug1": "tiapride", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with triprolidine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Pizotifen.", "severity": 2}
{"drug1": "triamterene", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with amitriptyline.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Flibanserin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Tolcapone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "pramipexole", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Pomalidomide.", "severity": 2}
{"drug1": "reserpine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nifedipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Potassium citrate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with gabapentin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with gabapentin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with etodolac.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with DESONIDE.", "severity": 2}
{"drug1": "risperidone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with ketamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "etizolam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with baclofen.", "severity": 2}
{"drug1": "propofol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Nebivolol.", "severity": 2}
{"drug1": "benztropine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with clonazepam.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with tubocurarine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Carbetocin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with methylprednisolone.", "severity": 2}
{"drug1": "clonidine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "bromazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with thiamylal.", "severity": 2}
{"drug1": "benztropine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Pentolinium.", "severity": 2}
{"drug1": "ethanol", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with citalopram.", "severity": 2}
{"drug1": "tioconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with nifedipine.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with pravastatin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with quinapril.", "severity": 2}
{"drug1": "metolazone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Nebivolol.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with venlafaxine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with MOLINDONE.", "severity": 2}
{"drug1": "clonidine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with tiagabine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Fencamfamin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with dipyridamole.", "severity": 2}
{"drug1": "loxapine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with primidone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with mefenamic acid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with azelastine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with NAPROXEN.", "severity": 2}
{"drug1": "risperidone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with HEROIN.", "severity": 2}
{"drug1": "citalopram", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Phenelzine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with meclizine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with bromocriptine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with xylometazoline.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Risedronic acid.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with dexamethasone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Tixocortol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Pipotiazine.", "severity": 2}
{"drug1": "procaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with butalbital.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with pargyline.", "severity": 2}
{"drug1": "butamben", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Retigabine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with clonidine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Flibanserin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with tizanidine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Methadyl acetate.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with ethotoin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with meclizine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with leflunomide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Lurasidone.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Clevidipine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Aripiprazole.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with chlorprothixene.", "severity": 2}
{"drug1": "formestane", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with ambenonium.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ACENOCOUMAROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Agomelatine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with clidinium.", "severity": 2}
{"drug1": "butenafine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with nitrendipine.", "severity": 2}
{"drug1": "propofol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Aceprometazine.", "severity": 2}
{"drug1": "propofol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with terazosin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Fosphenytoin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with oxymorphone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Teriflunomide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with tetracaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with zopiclone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with topiramate.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Riociguat.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with methyldopa.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Telmisartan.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Desloratadine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with apraclonidine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "meperidine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with nortriptyline.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Pomalidomide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with diazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with maprotiline.", "severity": 2}
{"drug1": "labetalol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with quinapril.", "severity": 2}
{"drug1": "labetalol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with chlorothiazide.", "severity": 2}
{"drug1": "labetalol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Nebivolol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Pizotifen.", "severity": 2}
{"drug1": "nabumetone", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with mycophenolic acid.", "severity": 2}
{"drug1": "THYMOL", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with barnidipine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with butamben.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with IDARUBICIN.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Varenicline.", "severity": 2}
{"drug1": "Butethal", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Iloperidone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with hydralazine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Levalbuterol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Almotriptan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with penbutolol.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "kanamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with kanamycin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with nitrazepam.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with tolmetin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Asenapine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with ethosuximide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with promethazine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with clonazepam.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with METAXALONE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with isoproterenol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Ticagrelor.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with promethazine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with zotepine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Flibanserin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Melatonin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with clonazepam.", "severity": 2}
{"drug1": "amobarbital", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with promethazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with maprotiline.", "severity": 2}
{"drug1": "promazine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with midazolam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Fencamfamin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with clomipramine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with tiagabine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Difenoxin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with zonisamide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with sulfasalazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with mirtazapine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with MELPERONE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with zotepine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with scopolamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Salsalate.", "severity": 2}
{"drug1": "valsartan", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ESMOLOL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with isoxsuprine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Clodronic Acid.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with dexamethasone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with methyldopa.", "severity": 2}
{"drug1": "propranolol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with indapamide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with prazosin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with loratadine.", "severity": 2}
{"drug1": "meperidine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with methazolamide.", "severity": 2}
{"drug1": "meperidine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Eplerenone.", "severity": 2}
{"drug1": "meperidine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with topiramate.", "severity": 2}
{"drug1": "levorphanol", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "diclofenac", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with mycophenolic acid.", "severity": 2}
{"drug1": "amifostine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Canagliflozin.", "severity": 2}
{"drug1": "pimozide", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with nitrazepam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with GUANFACINE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Pomalidomide.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "EDOXABAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with EDOXABAN.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with ethotoin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Olopatadine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "indomethacin", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with sulindac.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with loratadine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with ethosuximide.", "severity": 2}
{"drug1": "morphine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with hydralazine.", "severity": 2}
{"drug1": "morphine", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Potassium citrate.", "severity": 2}
{"drug1": "secobarbital", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with buspirone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with thiopental.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Olopatadine.", "severity": 2}
{"drug1": "valsartan", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with benazepril.", "severity": 2}
{"drug1": "suprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with apraclonidine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with primidone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with brotizolam.", "severity": 2}
{"drug1": "etizolam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Milnacipran.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Desloratadine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Pipamperone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with sevoflurane.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with methyclothiazide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Tolcapone.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with amitriptyline.", "severity": 2}
{"drug1": "doxepin", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Cyamemazine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with homoharringtonine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with isoetharine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Zucapsaicin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with citalopram.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Ethylmorphine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with nortriptyline.", "severity": 2}
{"drug1": "pentazocine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with amoxapine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Naftifine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Nelarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Nelarabine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with equilin.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with dibucaine.", "severity": 2}
{"drug1": "butamben", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Levetiracetam.", "severity": 2}
{"drug1": "trimipramine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with terbutaline.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with hydromorphone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Levocetirizine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with aspirin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with flunarizine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with clonazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with promethazine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with amisulpride.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rosuvastatin is combined with mecamylamine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with venlafaxine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Repaglinide.", "severity": 2}
{"drug1": "ramipril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with epirizole.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with etodolac.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "midazolam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with tetracaine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with MELPERONE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with cinoxacin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with levodopa.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with buspirone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with enalapril.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with acetaminophen.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with fosinopril.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with chlormezanone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with doxepin.", "severity": 2}
{"drug1": "ethanol", "drug2": "Isotretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Isotretinoin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Difenoxin.", "severity": 2}
{"drug1": "doxepin", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with levodopa.", "severity": 2}
{"drug1": "phenindione", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenindione is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "topiramate", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with carisoprodol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with prazosin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with loratadine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with nefazodone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Mometasone.", "severity": 2}
{"drug1": "felbamate", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with sertraline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with imipramine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with baclofen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Mersalyl.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with doxepin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Propoxycaine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with methadone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Pramocaine.", "severity": 2}
{"drug1": "risperidone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with chlorprothixene.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Ciclesonide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with DESONIDE.", "severity": 2}
{"drug1": "furosemide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "codeine", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with duloxetine.", "severity": 2}
{"drug1": "pimozide", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with clidinium.", "severity": 2}
{"drug1": "thiotepa", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiotepa is combined with clozapine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with fluoxetine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with levodopa.", "severity": 2}
{"drug1": "clorazepate", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with perphenazine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicumarol is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "methysergide", "drug2": "RUCAPARIB", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with RUCAPARIB.", "severity": 2}
{"drug1": "bifonazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with bepridil.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Ramelteon.", "severity": 2}
{"drug1": "ramipril", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with isradipine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Pinaverium.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Halobetasol.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with ALFENTANIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Tasimelteon.", "severity": 2}
{"drug1": "acebutolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with acetylcholine.", "severity": 2}
{"drug1": "Trospium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with olanzapine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with nefazodone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with doxepin.", "severity": 2}
{"drug1": "midazolam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with haloperidol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "halcinonide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with sertraline.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with irbesartan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with floctafenine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "quinapril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with levodopa.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Ketobemidone.", "severity": 2}
{"drug1": "Propiverine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with propoxyphene.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Agomelatine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Tapentadol.", "severity": 2}
{"drug1": "benztropine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Mirabegron.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with brotizolam.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with meclizine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apixaban is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with quazepam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with homoharringtonine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with mefenamic acid.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with diflorasone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Mometasone.", "severity": 2}
{"drug1": "medrysone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with sparfloxacin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with isradipine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with NAPROXEN.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Olopatadine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Telmisartan.", "severity": 2}
{"drug1": "Nabilone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with apraclonidine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with methyldopa.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Empagliflozin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with paramethasone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with difluprednate.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "isradipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with dantrolene.", "severity": 2}
{"drug1": "diflunisal", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with halcinonide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with digoxin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with sulpiride.", "severity": 2}
{"drug1": "enalapril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "clozapine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with metolazone.", "severity": 2}
{"drug1": "topiramate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Tasimelteon.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with chloroquine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with venlafaxine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Ketobemidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with dantrolene.", "severity": 2}
{"drug1": "isradipine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with penbutolol.", "severity": 2}
{"drug1": "terbinafine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with nitrendipine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with ketoprofen.", "severity": 2}
{"drug1": "reserpine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with lidocaine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Propacetamol.", "severity": 2}
{"drug1": "reserpine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with clemastine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with clonazepam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with promethazine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with sulpiride.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with Temsirolimus.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with thalidomide.", "severity": 2}
{"drug1": "buspirone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with carisoprodol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Perospirone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Clodronic Acid.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Bretylium.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Butylscopolamine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Iloperidone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with sparfloxacin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with hyoscyamine.", "severity": 2}
{"drug1": "cocaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with methimazole.", "severity": 2}
{"drug1": "hexetidine", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with cinnarizine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Bretylium.", "severity": 2}
{"drug1": "Articaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with cetirizine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with equilin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Pregabalin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "pergolide", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Enasidenib.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with Calcipotriol.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with promethazine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with clonazepam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Pentolinium.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with aspirin.", "severity": 2}
{"drug1": "midazolam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with doxepin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with captopril.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with spironolactone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with ketoprofen.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with maprotiline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with estazolam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Isavuconazonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Isavuconazonium.", "severity": 2}
{"drug1": "Asenapine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with mesoridazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with GUANFACINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with midazolam.", "severity": 2}
{"drug1": "loteprednol", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with enoxacin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with glutethimide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with dantrolene.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with cetirizine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with methazolamide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with barnidipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "felodipine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with penbutolol.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorinostat is combined with clozapine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "minoxidil", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with BISOPROLOL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with papaverine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "plicamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with plicamycin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nimodipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with sulpiride.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with progesterone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Calcium acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with Calcium acetate.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with 4-PHENYLBUTYRIC ACID.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Sorafenib.", "severity": 2}
{"drug1": "azelastine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with difluprednate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Melatonin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with tiapride.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with cetirizine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Apremilast.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with fenbufen.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Risedronic acid.", "severity": 2}
{"drug1": "atenolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Phenelzine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Doxercalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with Doxercalciferol.", "severity": 2}
{"drug1": "itraconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with dipivefrin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with reserpine.", "severity": 2}
{"drug1": "amifostine", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Clofarabine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "argatroban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with argatroban.", "severity": 2}
{"drug1": "amcinonide", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "budesonide", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with donepezil.", "severity": 2}
{"drug1": "levorphanol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with cetirizine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with protriptyline.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with clonazepam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with etizolam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with meperidine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with oxaprozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Propacetamol.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with xylometazoline.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "Trospium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Nelarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Nelarabine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with carisoprodol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Iloperidone.", "severity": 2}
{"drug1": "nadolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with floctafenine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with fexofenadine.", "severity": 2}
{"drug1": "Benidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with flunarizine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Fluspirilene.", "severity": 2}
{"drug1": "HEROIN", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with acetazolamide.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Fesoterodine.", "severity": 2}
{"drug1": "trazodone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with clidinium.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Cis-mdp.", "severity": 2}
{"drug1": "loxapine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with HEROIN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with atorvastatin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with isoproterenol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "prazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "tiapride", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with efavirenz.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Ethylmorphine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Nepafenac.", "severity": 2}
{"drug1": "trapidil", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Fencamfamin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Milnacipran.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with nitrous oxide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Pomalidomide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Telmisartan.", "severity": 2}
{"drug1": "atenolol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with AMILORIDE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Etoricoxib.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Difenoxin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Desloratadine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with zaleplon.", "severity": 2}
{"drug1": "levorphanol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with mepivacaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Fospropofol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BOPINDOLOL is combined with floctafenine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with venlafaxine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Deferasirox.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with carbamazepine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "quinapril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with isoxsuprine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Deferasirox.", "severity": 2}
{"drug1": "thiopental", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with cetirizine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Riociguat.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with doxepin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with leflunomide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with methylphenidate.", "severity": 2}
{"drug1": "diazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Retigabine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Riociguat.", "severity": 2}
{"drug1": "reserpine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Empagliflozin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "buspirone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Pizotifen.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with mefloquine.", "severity": 2}
{"drug1": "quazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with topiramate.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with mesalamine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with perphenazine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with loteprednol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with meclofenamic acid.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "rasagiline", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with domperidone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with penbutolol.", "severity": 2}
{"drug1": "methysergide", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with buprenorphine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "thiothixene", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with triflupromazine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with memantine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Normethadone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with hydralazine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with pimozide.", "severity": 2}
{"drug1": "prazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with olanzapine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with metoclopramide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with sertraline.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with PROCATEROL.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with alclofenac.", "severity": 2}
{"drug1": "zopiclone", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with sevoflurane.", "severity": 2}
{"drug1": "nimodipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with pravastatin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ketamine.", "severity": 2}
{"drug1": "sulfamerazine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamerazine is combined with mecamylamine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with benazepril.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with amitriptyline.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Tolcapone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Normethadone.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with nilvadipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Flibanserin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with vigabatrin.", "severity": 2}
{"drug1": "benazepril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "rasagiline", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with sevoflurane.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "clarithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clarithromycin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with metoclopramide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with chlorprothixene.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with paroxetine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with mianserin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with donepezil.", "severity": 2}
{"drug1": "clemastine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with tubocurarine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with zaltoprofen.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with benzyl alcohol.", "severity": 2}
{"drug1": "cocaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with efavirenz.", "severity": 2}
{"drug1": "procarbazine", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with domperidone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with fleroxacin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with pentazocine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with SERATRODAST.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with promethazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with lisinopril.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with nitroglycerin.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with HEROIN.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "metyrapone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metyrapone is combined with atorvastatin.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "propofol", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with levorphanol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Tixocortol.", "severity": 2}
{"drug1": "enalapril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with papaverine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with nifedipine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with loratadine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ramipril.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with alclometasone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nisoldipine.", "severity": 2}
{"drug1": "carprofen", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Nabilone", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with trandolapril.", "severity": 2}
{"drug1": "lorazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with dyclonine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "pentobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with pentobarbital.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "carprofen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Deferasirox.", "severity": 2}
{"drug1": "amoxapine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with meclizine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with desipramine.", "severity": 2}
{"drug1": "doxycycline", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with oxycodone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Flibanserin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with levodopa.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with GUANFACINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with zonisamide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with dextromethorphan.", "severity": 2}
{"drug1": "glutethimide", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Articaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with methazolamide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Empagliflozin.", "severity": 2}
{"drug1": "clemastine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Tolcapone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with ondansetron.", "severity": 2}
{"drug1": "zaleplon", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with tiagabine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Ethylmorphine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "zaleplon", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with flunarizine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Aceclofenac.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with zaltoprofen.", "severity": 2}
{"drug1": "triamterene", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with apraclonidine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with trimipramine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with fosinopril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "desipramine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Levalbuterol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Risedronic acid.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telithromycin is combined with Temsirolimus.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Trametinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Trametinib.", "severity": 2}
{"drug1": "tolmetin", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with DESONIDE.", "severity": 2}
{"drug1": "trapidil", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with diflunisal.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with zotepine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with nortriptyline.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Clodronic Acid.", "severity": 2}
{"drug1": "zotepine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with vigabatrin.", "severity": 2}
{"drug1": "ramipril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "loratadine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with scopolamine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with etoposide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with clomipramine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Pramocaine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with isoxsuprine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ramipril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Nebivolol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with theobromine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with moclobemide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with amoxapine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with etizolam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Melatonin.", "severity": 2}
{"drug1": "promazine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with triflupromazine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with clonazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with gabapentin.", "severity": 2}
{"drug1": "propofol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Pomalidomide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Etoricoxib.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with rivastigmine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with topiramate.", "severity": 2}
{"drug1": "propofol", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Levomilnacipran.", "severity": 2}
{"drug1": "tolterodine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with paroxetine.", "severity": 2}
{"drug1": "felbamate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Flibanserin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with quetiapine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with diphenhydramine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "loxapine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with propofol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Tasimelteon.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with triprolidine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with memantine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with methocarbamol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with isoxsuprine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Estrone sulfate.", "severity": 2}
{"drug1": "valsartan", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with methazolamide.", "severity": 2}
{"drug1": "terconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "ethanol", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with fluoxetine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with clomipramine.", "severity": 2}
{"drug1": "ethanol", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with duloxetine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with valsartan.", "severity": 2}
{"drug1": "Normethadone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with scopolamine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Normethadone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with D-mannitol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with chlorpheniramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nifedipine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with ramipril.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with papaverine.", "severity": 2}
{"drug1": "reserpine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Normethadone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with midazolam.", "severity": 2}
{"drug1": "Normethadone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with flunarizine.", "severity": 2}
{"drug1": "meperidine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with felbamate.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Canrenoic acid.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with topiramate.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with MELPERONE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with zotepine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with AMILORIDE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with alclometasone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "methotrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimethoprim is combined with methotrexate.", "severity": 2}
{"drug1": "fosinopril", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with labetalol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with formestane.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "fosinopril", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with AMILORIDE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Flibanserin.", "severity": 2}
{"drug1": "pergolide", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with ambroxol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with mepivacaine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with desoximetasone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with alclometasone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "procaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with dexamethasone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with tizanidine.", "severity": 2}
{"drug1": "sotalol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "quinidine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "terconazole", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with fluvastatin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with fludiazepam.", "severity": 2}
{"drug1": "flumethasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Ciclesonide.", "severity": 2}
{"drug1": "morphine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Pizotifen.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Iloperidone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Levetiracetam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with phentolamine.", "severity": 2}
{"drug1": "trapidil", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with tizanidine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with nalidixic acid.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with DEZOCINE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with malathion.", "severity": 2}
{"drug1": "Droxicam", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with NITROUS ACID.", "severity": 2}
{"drug1": "tizanidine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Agomelatine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with sulfasalazine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with VERAPAMIL.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Melatonin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Fencamfamin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with promethazine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with promethazine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with clonazepam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with clonidine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "temazepam", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with codeine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with D-mannitol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Melatonin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with scopolamine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with budesonide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with lisinopril.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with nitroglycerin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with citalopram.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with methadone.", "severity": 2}
{"drug1": "sulindac", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with flurandrenolide.", "severity": 2}
{"drug1": "halothane", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Ketobemidone.", "severity": 2}
{"drug1": "felodipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with triflupromazine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with hydrocortisone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with tiapride.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with nimodipine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with edrophonium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with levodopa.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with cyclothiazide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with chlorprothixene.", "severity": 2}
{"drug1": "codeine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with flurazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PRIMAQUINE is combined with dapsone.", "severity": 2}
{"drug1": "codeine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with furosemide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with ethosuximide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Pizotifen.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with buprenorphine.", "severity": 2}
{"drug1": "triazolam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with thiopental.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with meclizine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Lornoxicam.", "severity": 2}
{"drug1": "salicylamide", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "metaraminol", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "valsartan", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with diltiazem.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with isoproterenol.", "severity": 2}
{"drug1": "quinidine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with atorvastatin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with clidinium.", "severity": 2}
{"drug1": "metolazone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with AMILORIDE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with pimozide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "midazolam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Levomepromazine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Ramelteon.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with quetiapine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with halcinonide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with difluprednate.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with olanzapine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Ketobemidone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with fosinopril.", "severity": 2}
{"drug1": "oxazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with doxepin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Etoricoxib.", "severity": 2}
{"drug1": "etodolac", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Cis-mdp.", "severity": 2}
{"drug1": "felbamate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Desloratadine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Eprosartan.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Lomitapide.", "severity": 2}
{"drug1": "estazolam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with clozapine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Olopatadine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with mepivacaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with epirizole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with galanthamine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Propacetamol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with clonazepam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with promethazine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Melatonin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Normethadone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Eprosartan.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "pentoxifylline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with pentoxifylline.", "severity": 2}
{"drug1": "loxapine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Oxetacaine.", "severity": 2}
{"drug1": "losartan", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with indapamide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Iloperidone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with meclizine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with bupivacaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Ropivacaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Etomidate.", "severity": 2}
{"drug1": "maprotiline", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Normethadone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with losartan.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with hydromorphone.", "severity": 2}
{"drug1": "ramipril", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with fosinopril.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with felbamate.", "severity": 2}
{"drug1": "Salsalate", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with fludrocortisone.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "metolazone", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Bretylium.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with flumethasone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with tetracaine.", "severity": 2}
{"drug1": "benztropine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with oxymorphone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Drospirenone.", "severity": 2}
{"drug1": "clozapine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with cinoxacin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with felbamate.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Pipamperone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Zoledronic acid.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with paroxetine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Oxetacaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with periciazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with atorvastatin.", "severity": 2}
{"drug1": "dapsone", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with celecoxib.", "severity": 2}
{"drug1": "mesalamine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with diflorasone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with selegiline.", "severity": 2}
{"drug1": "propofol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with fenoprofen.", "severity": 2}
{"drug1": "alclofenac", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with alclometasone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when decamethonium is combined with nicotine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when decamethonium is combined with Cevimeline.", "severity": 2}
{"drug1": "halothane", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with clidinium.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "halothane", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "sulconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with isradipine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with tubocurarine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with clonidine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with benazepril.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with diflorasone.", "severity": 2}
{"drug1": "Trospium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with butorphanol.", "severity": 2}
{"drug1": "halothane", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with sotalol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with mefloquine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Metipranolol.", "severity": 2}
{"drug1": "meperidine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Ramelteon.", "severity": 2}
{"drug1": "estazolam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with flunitrazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with medrysone.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with sertraline.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with felodipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with maprotiline.", "severity": 2}
{"drug1": "diazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with glutethimide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with loxapine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Ximelagatran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with Ximelagatran.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Difenoxin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with zotepine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with rescinnamine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with NITROUS ACID.", "severity": 2}
{"drug1": "benzocaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with protriptyline.", "severity": 2}
{"drug1": "benzocaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with cetirizine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with thiamylal.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with halothane.", "severity": 2}
{"drug1": "propofol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Fospropofol.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with methylprednisolone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with alclofenac.", "severity": 2}
{"drug1": "meperidine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Butethal.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with butalbital.", "severity": 2}
{"drug1": "clorazepate", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with chloral hydrate.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with carprofen.", "severity": 2}
{"drug1": "nimodipine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with terazosin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with fludiazepam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with phenytoin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with mycophenolic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with furosemide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Risedronic acid.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with thioridazine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with propofol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with amisulpride.", "severity": 2}
{"drug1": "benazepril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with indomethacin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Pramocaine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "clidinium", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with acebutolol.", "severity": 2}
{"drug1": "baclofen", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with primidone.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "methysergide", "drug2": "Palbociclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Palbociclib.", "severity": 2}
{"drug1": "propranolol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with dantrolene.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with clonazepam.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with doxazosin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with AMILORIDE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Rotigotine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with labetalol.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Temsirolimus is combined with atorvastatin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Melatonin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with nortriptyline.", "severity": 2}
{"drug1": "Tramadol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with D-mannitol.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with enalapril.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with primidone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with scopolamine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "captopril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with indomethacin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with rasagiline.", "severity": 2}
{"drug1": "streptozocin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when streptozocin is combined with leflunomide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Pipamperone.", "severity": 2}
{"drug1": "mechlorethamine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mechlorethamine is combined with leflunomide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Pipotiazine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with zonisamide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with edrophonium.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with oxymetazoline.", "severity": 2}
{"drug1": "Butethal", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Articaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with olanzapine.", "severity": 2}
{"drug1": "procaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with MELPERONE.", "severity": 2}
{"drug1": "procaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with zotepine.", "severity": 2}
{"drug1": "clozapine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with levorphanol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with SERTINDOLE.", "severity": 2}
{"drug1": "morphine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diethylstilbestrol is combined with Ospemifene.", "severity": 2}
{"drug1": "amobarbital", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with procaine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "amiodarone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with isocarboxazid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with dexamethasone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with etodolac.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with acebutolol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Fencamfamin.", "severity": 2}
{"drug1": "clozapine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with propoxyphene.", "severity": 2}
{"drug1": "celecoxib", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with hydrocortisone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Oxetacaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Ethylmorphine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Pizotifen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Melatonin.", "severity": 2}
{"drug1": "enalapril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with flurbiprofen.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Paliperidone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with trazodone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with estazolam.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with lovastatin.", "severity": 2}
{"drug1": "dopamine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with clenbuterol.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with NICORANDIL.", "severity": 2}
{"drug1": "clonidine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with D-mannitol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Trospium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "temazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with chlorthalidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nilvadipine.", "severity": 2}
{"drug1": "losartan", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with methyldopa.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with periciazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with hydralazine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with dibucaine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Pentolinium.", "severity": 2}
{"drug1": "diazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with selegiline.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with tiapride.", "severity": 2}
{"drug1": "clozapine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with pimozide.", "severity": 2}
{"drug1": "baclofen", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with triprolidine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Mirabegron.", "severity": 2}
{"drug1": "baclofen", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with methocarbamol.", "severity": 2}
{"drug1": "nadolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with cilazapril.", "severity": 2}
{"drug1": "suprofen", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with fenbufen.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when IDARUBICIN is combined with clozapine.", "severity": 2}
{"drug1": "temazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with zotepine.", "severity": 2}
{"drug1": "suprofen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with diflorasone.", "severity": 2}
{"drug1": "benazepril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "butamben", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with felbamate.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with trandolapril.", "severity": 2}
{"drug1": "lisinopril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with mequitazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with mecamylamine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with carisoprodol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with azelastine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with MOLINDONE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Retigabine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with METAXALONE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with ALFENTANIL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Halazepam.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amfepramone is combined with selegiline.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Pefloxacin.", "severity": 2}
{"drug1": "epirizole", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Zoledronic acid.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with CLONIXIN.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ethotoin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with tretinoin.", "severity": 2}
{"drug1": "methadone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with enflurane.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "butamben", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with GUANFACINE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with spironolactone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with tranylcypromine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with bupivacaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Ropivacaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Etomidate.", "severity": 2}
{"drug1": "irbesartan", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Spirapril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Milnacipran.", "severity": 2}
{"drug1": "pergolide", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with prednisone.", "severity": 2}
{"drug1": "pergolide", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with astemizole.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with manidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Ramelteon.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with haloperidol.", "severity": 2}
{"drug1": "reserpine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Azelnidipine.", "severity": 2}
{"drug1": "aspirin", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with alclometasone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with cilnidipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Efonidipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Lacidipine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with Olsalazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with vinorelbine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with clozapine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Eprosartan.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Bexarotene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when demeclocycline is combined with Bexarotene.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "retinol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with retinol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Luliconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Luliconazole.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with triprolidine.", "severity": 2}
{"drug1": "Articaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with methocarbamol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with citalopram.", "severity": 2}
{"drug1": "selegiline", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with procarbazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with CYCLIZINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with terazosin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with chlormezanone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with dipyridamole.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with trazodone.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with fexofenadine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with flunarizine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Pizotifen.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "midodrine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with clenbuterol.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Bretylium.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Lormetazepam.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Iloperidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "bleomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with bleomycin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "chlorambucil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with chlorambucil.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nilvadipine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Raltitrexed", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Raltitrexed.", "severity": 2}
{"drug1": "nefazodone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Flibanserin.", "severity": 2}
{"drug1": "prazosin", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Riociguat.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with tolmetin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Levomilnacipran.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with haloperidol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Fospropofol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with benzyl alcohol.", "severity": 2}
{"drug1": "trazodone", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with naratriptan.", "severity": 2}
{"drug1": "trazodone", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with rizatriptan.", "severity": 2}
{"drug1": "trazodone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with fexofenadine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with dantrolene.", "severity": 2}
{"drug1": "benazepril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with nifedipine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bevantolol is combined with floctafenine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Ketobemidone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with triprolidine.", "severity": 2}
{"drug1": "promazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with scopolamine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with terbutaline.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with methocarbamol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Retigabine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Halazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Normethadone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Flibanserin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "aspirin", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Loxoprofen.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Pipotiazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with butalbital.", "severity": 2}
{"drug1": "aspirin", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with CLONIXIN.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Dapagliflozin.", "severity": 2}
{"drug1": "isradipine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with felodipine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Pizotifen.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with amisulpride.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with carvedilol.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Levocetirizine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with doxepin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Sorafenib.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with tolfenamic acid.", "severity": 2}
{"drug1": "enalapril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with suprofen.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Fospropofol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with levorphanol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "methylergonovine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with methylergonovine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Quinine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with ethotoin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with triprolidine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Riociguat.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Levomepromazine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Torasemide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with clindamycin.", "severity": 2}
{"drug1": "losartan", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with apraclonidine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with danazol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with bromazepam.", "severity": 2}
{"drug1": "methadone", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with butamben.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Tasimelteon.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with PROCATEROL.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Tixocortol.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with xylometazoline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Flupentixol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with levodopa.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with etizolam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Loxoprofen.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with sotalol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with scopolamine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with rapamycin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with estrone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with buspirone.", "severity": 2}
{"drug1": "Articaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with tetracaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "cytarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with cytarabine.", "severity": 2}
{"drug1": "eperisone", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "lorazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with sertraline.", "severity": 2}
{"drug1": "lorazepam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with pimozide.", "severity": 2}
{"drug1": "tetracaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with citalopram.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with meclofenamic acid.", "severity": 2}
{"drug1": "losartan", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with nabumetone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "losartan", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with ketorolac.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "tiagabine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with zonisamide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with doxepin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with vigabatrin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with amcinonide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Cariprazine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Flibanserin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxorubicin is combined with leflunomide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with brotizolam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with topiramate.", "severity": 2}
{"drug1": "proparacaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with clidinium.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Ramelteon.", "severity": 2}
{"drug1": "pentazocine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with brotizolam.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Deferasirox.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with desoximetasone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with doxepin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "pipobroman", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with pipobroman.", "severity": 2}
{"drug1": "morphine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with DEZOCINE.", "severity": 2}
{"drug1": "morphine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Levetiracetam.", "severity": 2}
{"drug1": "morphine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nadolol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with oxybutynin.", "severity": 2}
{"drug1": "promazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Ciclesonide.", "severity": 2}
{"drug1": "methoxamine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with metaproterenol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Ciclesonide.", "severity": 2}
{"drug1": "clidinium", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with nefazodone.", "severity": 2}
{"drug1": "levodopa", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Pipotiazine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with spironolactone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "levodopa", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with pargyline.", "severity": 2}
{"drug1": "benztropine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with buprenorphine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ticagrelor is combined with salicylic acid.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with oxycodone.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Tapentadol.", "severity": 2}
{"drug1": "pargyline", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with linezolid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with zaltoprofen.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Aceclofenac.", "severity": 2}
{"drug1": "butorphanol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with MELPERONE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with modafinil.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with fenbufen.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Mometasone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "colchicine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with colchicine.", "severity": 2}
{"drug1": "etizolam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with paroxetine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with METAXALONE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "butalbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with vigabatrin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Isometheptene.", "severity": 2}
{"drug1": "loxapine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with chloral hydrate.", "severity": 2}
{"drug1": "lisinopril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with fenoprofen.", "severity": 2}
{"drug1": "clozapine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nilvadipine.", "severity": 2}
{"drug1": "codeine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Amrinone", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with fluvastatin.", "severity": 2}
{"drug1": "codeine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ondansetron.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Eprosartan.", "severity": 2}
{"drug1": "Amrinone", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with Rosuvastatin.", "severity": 2}
{"drug1": "benztropine", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with hyoscyamine.", "severity": 2}
{"drug1": "codeine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with zonisamide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Etoricoxib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with amitriptyline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Flupentixol.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Butethal.", "severity": 2}
{"drug1": "rasagiline", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with promazine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with spironolactone.", "severity": 2}
{"drug1": "Butethal", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with levodopa.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with droperidol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with flunarizine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with clonazepam.", "severity": 2}
{"drug1": "thiothixene", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with promethazine.", "severity": 2}
{"drug1": "metolazone", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Tolcapone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Melatonin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with irbesartan.", "severity": 2}
{"drug1": "pramipexole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with felodipine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with MOLINDONE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Desloratadine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with penbutolol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with topiramate.", "severity": 2}
{"drug1": "procarbazine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with alclofenac.", "severity": 2}
{"drug1": "Articaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with clomipramine.", "severity": 2}
{"drug1": "Butethal", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with oxprenolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ramipril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with niflumic acid.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Sacubitril.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Mirabegron.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with penbutolol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with tiapride.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with DEZOCINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with isoxsuprine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Pipotiazine.", "severity": 2}
{"drug1": "risperidone", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with estazolam.", "severity": 2}
{"drug1": "imipramine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Ciclesonide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with Paricalcitol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with antipyrine.", "severity": 2}
{"drug1": "equilin", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with norfloxacin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with cyclothiazide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with tetracaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with terazosin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Aliskiren.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Pipotiazine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with zotepine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with MELPERONE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with acebutolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with metoprolol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Escitalopram.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with xylometazoline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with moclobemide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Varenicline", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Varenicline is combined with nicotine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Iloperidone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with papaverine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Normethadone.", "severity": 2}
{"drug1": "indinavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indinavir is combined with meperidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Cariprazine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Levetiracetam.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with codeine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with fleroxacin.", "severity": 2}
{"drug1": "brotizolam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with etizolam.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Desloratadine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Articaine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with clomipramine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with oxprenolol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with fexofenadine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Asenapine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with prazepam.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with paroxetine.", "severity": 2}
{"drug1": "risperidone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Pramocaine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with dichlorphenamide.", "severity": 2}
{"drug1": "risperidone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Propoxycaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with fluocinonide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with NICORANDIL.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with CLONIXIN.", "severity": 2}
{"drug1": "butorphanol", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with propofol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Loxoprofen.", "severity": 2}
{"drug1": "Asenapine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with baclofen.", "severity": 2}
{"drug1": "prednisone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with enoxacin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Droxicam.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with cilazapril.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "triprolidine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Etidocaine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with levodopa.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "oxycodone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with loratadine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with MELPERONE.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bevantolol is combined with Cevimeline.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bevantolol is combined with nicotine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Mephobarbital.", "severity": 2}
{"drug1": "nimesulide", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Fluprednidene.", "severity": 2}
{"drug1": "reserpine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Ketobemidone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with clidinium.", "severity": 2}
{"drug1": "carprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "dibucaine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with procaine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with trimipramine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with zonisamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with cocaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with tiagabine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Eplerenone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with ondansetron.", "severity": 2}
{"drug1": "Nabilone", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Articaine.", "severity": 2}
{"drug1": "quazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with etodolac.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with ethotoin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with hydrocortisone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Dexrazoxane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Dexrazoxane.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with ZILEUTON.", "severity": 2}
{"drug1": "phentolamine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with bumetanide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with pramipexole.", "severity": 2}
{"drug1": "risperidone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with propoxyphene.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Ciclesonide.", "severity": 2}
{"drug1": "risperidone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with dyclonine.", "severity": 2}
{"drug1": "zotepine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Valrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Valrubicin.", "severity": 2}
{"drug1": "benazepril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Droxicam.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Articaine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with flunarizine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atazanavir is combined with oxycodone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with fexofenadine.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with flunarizine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Ethylmorphine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with zaleplon.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Eprosartan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with bumetanide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with chlorothiazide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with quinapril.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with quinapril.", "severity": 2}
{"drug1": "tofisopam", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tofisopam is combined with atorvastatin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with nifedipine.", "severity": 2}
{"drug1": "Metixene", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with methadone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "risperidone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with carisoprodol.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with fleroxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with NAPROXEN.", "severity": 2}
{"drug1": "dibucaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with baclofen.", "severity": 2}
{"drug1": "secobarbital", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with DEZOCINE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with mefenamic acid.", "severity": 2}
{"drug1": "benazepril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with GUANFACINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Trospium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Mirabegron.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with METAXALONE.", "severity": 2}
{"drug1": "zotepine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Oxetacaine.", "severity": 2}
{"drug1": "meclizine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with GUANFACINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Pipotiazine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with PERHEXILINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with nitrazepam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with triamterene.", "severity": 2}
{"drug1": "pentazocine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with promethazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with protriptyline.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with nifedipine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with cetirizine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with furosemide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with HEROIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with METAXALONE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with DESONIDE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with duloxetine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Oxetacaine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Ramelteon.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Pramocaine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Levocetirizine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Butethal.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with amobarbital.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Lornoxicam.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with Vilazodone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Potassium citrate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with fexofenadine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Enalaprilat.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with paroxetine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with papaverine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with donepezil.", "severity": 2}
{"drug1": "triazolam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with chloral hydrate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Butethal", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Desloratadine.", "severity": 2}
{"drug1": "triazolam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with fludiazepam.", "severity": 2}
{"drug1": "gabapentin", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nifedipine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with cocaine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with PROCATEROL.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Canagliflozin.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Regadenoson", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Regadenoson.", "severity": 2}
{"drug1": "benztropine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with levorphanol.", "severity": 2}
{"drug1": "nystatin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with flunarizine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Etoricoxib.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with betaxolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Agomelatine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with selegiline.", "severity": 2}
{"drug1": "epirizole", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Deferasirox.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with nadolol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "IMIQUIMOD", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Agomelatine.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with propoxyphene.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with dyclonine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with oxycodone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with clonidine.", "severity": 2}
{"drug1": "indapamide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Deferasirox.", "severity": 2}
{"drug1": "codeine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with butalbital.", "severity": 2}
{"drug1": "indapamide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Metipranolol.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "bromazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with amisulpride.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Amrinone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Flibanserin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with desoximetasone.", "severity": 2}
{"drug1": "methadone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with chlorothiazide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Loxoprofen.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with fludiazepam.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with floctafenine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with chloral hydrate.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Spirapril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with zaltoprofen.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with methoxyflurane.", "severity": 2}
{"drug1": "selegiline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with PROCATEROL.", "severity": 2}
{"drug1": "selegiline", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with rasagiline.", "severity": 2}
{"drug1": "halothane", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Etidocaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with sevoflurane.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Fencamfamin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Aripiprazole.", "severity": 2}
{"drug1": "prazosin", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Dapagliflozin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with rapamycin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with chlorprothixene.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "clorazepate", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with levorphanol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with zonisamide.", "severity": 2}
{"drug1": "ramipril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Empagliflozin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with tiagabine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with salicylamide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with bumetanide.", "severity": 2}
{"drug1": "reserpine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with estazolam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with dipyridamole.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Lercanidipine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with amitriptyline.", "severity": 2}
{"drug1": "clozapine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with dibucaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Tolcapone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Nitroprusside.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with PROCATEROL.", "severity": 2}
{"drug1": "propofol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with promazine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with dantrolene.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with GUANFACINE.", "severity": 2}
{"drug1": "midodrine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with Calcipotriol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Clevidipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with cyclophosphamide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with phenytoin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "butorphanol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "quinapril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Olopatadine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with nitrazepam.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with benzocaine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with vigabatrin.", "severity": 2}
{"drug1": "piracetam", "drug2": "Liotrix", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when piracetam is combined with Liotrix.", "severity": 2}
{"drug1": "risperidone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with tizanidine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with vigabatrin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with lithium ion.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Tolcapone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Clevidipine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Levetiracetam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with topiramate.", "severity": 2}
{"drug1": "etodolac", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Halobetasol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with triprolidine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "metaraminol", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with dobutamine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Olopatadine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with benzocaine.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with VERAPAMIL.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Aceprometazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with mefloquine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Iloperidone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with D-mannitol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with cyclothiazide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with nortriptyline.", "severity": 2}
{"drug1": "buspirone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Levocetirizine.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "Entecavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with Entecavir.", "severity": 2}
{"drug1": "dyclonine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with proparacaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with flunarizine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Fluspirilene.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Flupentixol.", "severity": 2}
{"drug1": "ketamine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with ondansetron.", "severity": 2}
{"drug1": "ketamine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with tiagabine.", "severity": 2}
{"drug1": "ketamine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with cocaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Desloratadine.", "severity": 2}
{"drug1": "ketamine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with zonisamide.", "severity": 2}
{"drug1": "diazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with efavirenz.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with ethosuximide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with chlorthalidone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with irbesartan.", "severity": 2}
{"drug1": "loratadine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with vigabatrin.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with felodipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "isradipine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with timolol.", "severity": 2}
{"drug1": "amprenavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amprenavir is combined with meperidine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Levetiracetam.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with sulpiride.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with fexofenadine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with scopolamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with dipyridamole.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with D-mannitol.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with propoxyphene.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with DEZOCINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Ivacaftor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Ivacaftor.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with zaleplon.", "severity": 2}
{"drug1": "desipramine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Salbutamol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Melatonin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with promethazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with clonazepam.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Milnacipran.", "severity": 2}
{"drug1": "phenytoin", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with methocarbamol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with fluocinonide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with meclizine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with topiramate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with nitrous oxide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with glutethimide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with nadolol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Riociguat.", "severity": 2}
{"drug1": "biperiden", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with oxymorphone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with diphenhydramine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "gabapentin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with atorvastatin.", "severity": 2}
{"drug1": "biperiden", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with tubocurarine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with carprofen.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with ethotoin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with AMILORIDE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with zaltoprofen.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Pinaverium.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with sulfasalazine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with estrone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with SERATRODAST.", "severity": 2}
{"drug1": "halothane", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with minoxidil.", "severity": 2}
{"drug1": "tizanidine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with apraclonidine.", "severity": 2}
{"drug1": "halothane", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with metolazone.", "severity": 2}
{"drug1": "halothane", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Lercanidipine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with meclizine.", "severity": 2}
{"drug1": "formestane", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with triamcinolone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with ethosuximide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Pipamperone.", "severity": 2}
{"drug1": "butalbital", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Tasimelteon.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Pinaverium.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Tixocortol.", "severity": 2}
{"drug1": "butamben", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with fluoxetine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Fluprednidene.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with manidipine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Lacidipine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Efonidipine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with cilnidipine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Azelnidipine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Benidipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with pramipexole.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Fluspirilene.", "severity": 2}
{"drug1": "quinapril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with quetiapine.", "severity": 2}
{"drug1": "isradipine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with irbesartan.", "severity": 2}
{"drug1": "triazolam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with chlormezanone.", "severity": 2}
{"drug1": "triazolam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with ondansetron.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Riociguat.", "severity": 2}
{"drug1": "propofol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Articaine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Normethadone.", "severity": 2}
{"drug1": "Artemether", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with PERHEXILINE.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with dantrolene.", "severity": 2}
{"drug1": "thiothixene", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with cocaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with tiagabine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with ondansetron.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with zonisamide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with quetiapine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with oxprenolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with furosemide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with sevoflurane.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with prazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with quazepam.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Icatibant.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with ketoprofen.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with mecamylamine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with paramethasone.", "severity": 2}
{"drug1": "benazepril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ibuprofen.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Halazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with ethchlorvynol.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with loratadine.", "severity": 2}
{"drug1": "meperidine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with doxepin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with proparacaine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Phenelzine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with baclofen.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Etomidate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "lorazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with lorazepam.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with imipramine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with quinapril.", "severity": 2}
{"drug1": "meprobamate", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with primidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with vincristine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Bretylium.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "5-Fluorouracil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "topiramate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with tizanidine.", "severity": 2}
{"drug1": "bepridil", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with spironolactone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with alclofenac.", "severity": 2}
{"drug1": "cabergoline", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "topiramate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with amoxapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with fexofenadine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Linagliptin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with felbamate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with tetracaine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with sulfasalazine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Eprosartan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with benzyl alcohol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Paliperidone.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Propiverine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Pipamperone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with brotizolam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with methoxyflurane.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Mometasone.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Propiverine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with zonisamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with tiagabine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with ondansetron.", "severity": 2}
{"drug1": "Ibandronic Acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibandronic Acid is combined with Deferasirox.", "severity": 2}
{"drug1": "morphine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with spironolactone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with cisapride.", "severity": 2}
{"drug1": "morphine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with methocarbamol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Articaine.", "severity": 2}
{"drug1": "morphine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with triprolidine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "phenindione", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with phenindione.", "severity": 2}
{"drug1": "nimesulide", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with dexamethasone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with flunarizine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Fluspirilene.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with methazolamide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Eplerenone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with flunisolide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with acemetacin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Teriflunomide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Cis-mdp.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Clodronic Acid.", "severity": 2}
{"drug1": "baclofen", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with sertraline.", "severity": 2}
{"drug1": "pentamidine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with manidipine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Pomalidomide.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with loxapine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with triamterene.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with tiapride.", "severity": 2}
{"drug1": "tetracaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "quazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with lithium ion.", "severity": 2}
{"drug1": "quazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "quazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Butethal.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with betaxolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Riociguat.", "severity": 2}
{"drug1": "meprobamate", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with butalbital.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with selegiline.", "severity": 2}
{"drug1": "carprofen", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with nimesulide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Fluspirilene.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with pramipexole.", "severity": 2}
{"drug1": "rapamycin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with diltiazem.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with salicylic acid.", "severity": 2}
{"drug1": "tetracaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with dantrolene.", "severity": 2}
{"drug1": "brotizolam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with clomipramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Methadyl acetate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with glutethimide.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOFLOXACIN is combined with atorvastatin.", "severity": 2}
{"drug1": "suprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with HYDROCODONE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with trifluoperazine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Pipamperone.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Normethadone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with rasagiline.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with Empagliflozin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with linezolid.", "severity": 2}
{"drug1": "lovastatin", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lovastatin is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with formoterol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Dapagliflozin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Pipamperone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with butamben.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "midazolam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Tasimelteon.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with ibuprofen.", "severity": 2}
{"drug1": "captopril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with fenbufen.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Levocetirizine.", "severity": 2}
{"drug1": "codeine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with pentazocine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with meclizine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "butorphanol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with triamterene.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Retigabine.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CARBONATE is combined with misoprostol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ciprofloxacin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Gefitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Gefitinib.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Toloxatone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Enalaprilat.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with procarbazine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with methazolamide.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Vecuronium.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Thioproperazine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with phenytoin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Risedronic acid.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with sulfanilamide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Fosphenytoin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "biperiden", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with meperidine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Zoledronic acid.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with manidipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with chloroquine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with tolazoline.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "thalidomide", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with meperidine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with isradipine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Desloratadine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Olmesartan.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with DEZOCINE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with chlorthalidone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with isoxsuprine.", "severity": 2}
{"drug1": "methysergide", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "methysergide", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with daunorubicin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with salicylic acid.", "severity": 2}
{"drug1": "buspirone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Remoxipride.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with DESONIDE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with metolazone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with dibucaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with mitomycin C.", "severity": 2}
{"drug1": "lorazepam", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with fluvoxamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with bumetanide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with flunitrazepam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "vindesine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with vindesine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Ketobemidone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with HEROIN.", "severity": 2}
{"drug1": "butamben", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "sulindac", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with estrone.", "severity": 2}
{"drug1": "methysergide", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Lercanidipine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with clonazepam.", "severity": 2}
{"drug1": "methysergide", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Caspofungin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Enasidenib.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Melatonin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with salicylic acid.", "severity": 2}
{"drug1": "butalbital", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with paroxetine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Fondaparinux", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Fondaparinux.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with HEROIN.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloramphenicol is combined with Carbocisteine.", "severity": 2}
{"drug1": "topiramate", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with tizanidine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with methyclothiazide.", "severity": 2}
{"drug1": "methysergide", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with cisapride.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with epirizole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with proparacaine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with dexamethasone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with diclofenac.", "severity": 2}
{"drug1": "risperidone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Articaine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with tetracaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with indapamide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with triprolidine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with alclometasone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with methocarbamol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with spironolactone.", "severity": 2}
{"drug1": "losartan", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Torasemide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with zotepine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "losartan", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with furosemide.", "severity": 2}
{"drug1": "loxapine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with enalapril.", "severity": 2}
{"drug1": "nimodipine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with oxaprozin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with benzyl alcohol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "tegafur", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with tegafur.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with fludiazepam.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with dobutamine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with MOLINDONE.", "severity": 2}
{"drug1": "metolazone", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with diazoxide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Mersalyl.", "severity": 2}
{"drug1": "pimozide", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Pomalidomide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with cinoxacin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Retigabine.", "severity": 2}
{"drug1": "tiapride", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with maprotiline.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "actinomycin D", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with actinomycin D.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Butethal.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with amobarbital.", "severity": 2}
{"drug1": "tetracaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with carisoprodol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with isoxsuprine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Hexobarbital.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Pizotifen.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with donepezil.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with thiopental.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Lormetazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with atorvastatin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with loteprednol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Methadyl acetate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with rapamycin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with glutethimide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with thiopental.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with isoxsuprine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with paroxetine.", "severity": 2}
{"drug1": "estazolam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with nortriptyline.", "severity": 2}
{"drug1": "loteprednol", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with nalidixic acid.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with buprenorphine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Difenoxin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Netupitant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Netupitant.", "severity": 2}
{"drug1": "loteprednol", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with malathion.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with moclobemide.", "severity": 2}
{"drug1": "promethazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with dantrolene.", "severity": 2}
{"drug1": "Articaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with trimipramine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with trandolapril.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with benazepril.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Remoxipride.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with desoximetasone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nisoldipine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with benazepril.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with enflurane.", "severity": 2}
{"drug1": "midazolam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Hexobarbital.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with cilazapril.", "severity": 2}
{"drug1": "codeine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Tasimelteon.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Salbutamol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with glutethimide.", "severity": 2}
{"drug1": "labetalol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "prazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with triprolidine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Cyamemazine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with clidinium.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Levocetirizine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Ketobemidone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with fluoxetine.", "severity": 2}
{"drug1": "topiramate", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "dapsone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with metoclopramide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with chlorothiazide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with quinapril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with bumetanide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with glutethimide.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with risperidone.", "severity": 2}
{"drug1": "morphine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "morphine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with glutethimide.", "severity": 2}
{"drug1": "morphine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Flibanserin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Clobetasone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with imipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Clevidipine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with papaverine.", "severity": 2}
{"drug1": "clidinium", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Levocetirizine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with buprenorphine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with ergocalciferol.", "severity": 2}
{"drug1": "benztropine", "drug2": "procyclidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with procyclidine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with formestane.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with isoniazid.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "lorazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with levodopa.", "severity": 2}
{"drug1": "pergolide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with atorvastatin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with tetracaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with flunarizine.", "severity": 2}
{"drug1": "pergolide", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with mequitazine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Pefloxacin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with amisulpride.", "severity": 2}
{"drug1": "suprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with equilin.", "severity": 2}
{"drug1": "anagrelide", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with mesalamine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Temsirolimus.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Flupentixol.", "severity": 2}
{"drug1": "benztropine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with mecamylamine.", "severity": 2}
{"drug1": "procaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with primidone.", "severity": 2}
{"drug1": "benztropine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with pentazocine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with mesoridazine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with dantrolene.", "severity": 2}
{"drug1": "ramipril", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ESMOLOL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with nisoldipine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with acebutolol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with cyclophosphamide.", "severity": 2}
{"drug1": "ramipril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with carprofen.", "severity": 2}
{"drug1": "ketorolac", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with nabumetone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with levodopa.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Vecuronium.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Thioproperazine.", "severity": 2}
{"drug1": "ethanol", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with procarbazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with zolmitriptan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with loratadine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with methylene blue.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with Toloxatone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with maprotiline.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Doxercalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with Doxercalciferol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with METAXALONE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with brotizolam.", "severity": 2}
{"drug1": "Torasemide", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with minoxidil.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Teriflunomide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Iloperidone.", "severity": 2}
{"drug1": "procaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with methocarbamol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with toremifene.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Apremilast.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with alclofenac.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with oxymorphone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with amitriptyline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with propoxyphene.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Tolcapone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with dyclonine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "sertraline", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with procarbazine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with tubocurarine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with physostigmine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with thiamylal.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with thalidomide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Zoledronic acid.", "severity": 2}
{"drug1": "propofol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with cetirizine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with medrysone.", "severity": 2}
{"drug1": "epinastine", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with protriptyline.", "severity": 2}
{"drug1": "zonisamide", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "captopril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with ESMOLOL.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with vigabatrin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with doxepin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "methazolamide", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with acetazolamide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with hydralazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with fexofenadine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Canagliflozin.", "severity": 2}
{"drug1": "equilin", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with decamethonium.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with flurandrenolide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Tasimelteon.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olaparib is combined with Flibanserin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dronedarone is combined with oxycodone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "ATROPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with ATROPINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Metipranolol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Perospirone.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fondaparinux is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "ketorolac", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with resveratrol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with methadone.", "severity": 2}
{"drug1": "propranolol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with chlorothiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Clevidipine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with resveratrol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with protriptyline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "furazolidone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with apraclonidine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with quetiapine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ethchlorvynol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "propofol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with methyldopa.", "severity": 2}
{"drug1": "propofol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Desloratadine.", "severity": 2}
{"drug1": "propofol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Telmisartan.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Fesoterodine.", "severity": 2}
{"drug1": "propofol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with apraclonidine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with baclofen.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Loxoprofen.", "severity": 2}
{"drug1": "propofol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with mepivacaine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with loteprednol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with zotepine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with dexamethasone.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with mefenamic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Fosaprepitant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Frovatriptan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with NAPROXEN.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with irbesartan.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with topiramate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with topiramate.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with felodipine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with flunisolide.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with primidone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with thiamylal.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Oxetacaine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Pirlindole.", "severity": 2}
{"drug1": "isoflurane", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with triflupromazine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with reserpine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with tubocurarine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with paroxetine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with doxazosin.", "severity": 2}
{"drug1": "codeine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Agomelatine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with AMILORIDE.", "severity": 2}
{"drug1": "sertraline", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with protriptyline.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with suprofen.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with Pefloxacin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Besifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Besifloxacin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Eprosartan.", "severity": 2}
{"drug1": "diflorasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with enoxacin.", "severity": 2}
{"drug1": "brotizolam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Escitalopram.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with mitoxantrone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with lomustine.", "severity": 2}
{"drug1": "Trospium", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with tubocurarine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with duloxetine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with dorzolamide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with sparfloxacin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with rasagiline.", "severity": 2}
{"drug1": "Trospium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with oxymorphone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with imipramine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with HEROIN.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nortriptyline.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with amoxapine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with benazepril.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with acetazolamide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with triflupromazine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "zaleplon", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with lidocaine.", "severity": 2}
{"drug1": "meperidine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with glutethimide.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Retigabine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with acemetacin.", "severity": 2}
{"drug1": "zotepine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Butethal.", "severity": 2}
{"drug1": "temazepam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with amobarbital.", "severity": 2}
{"drug1": "temazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with lithium ion.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with tenoxicam.", "severity": 2}
{"drug1": "temazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethinyl estradiol is combined with Ospemifene.", "severity": 2}
{"drug1": "tropicamide", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with pirenzepine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with isoxsuprine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Ketobemidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Sorafenib.", "severity": 2}
{"drug1": "temazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "temazepam", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with alprazolam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with cilazapril.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with citalopram.", "severity": 2}
{"drug1": "temazepam", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with loxapine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Ethylmorphine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Nitroprusside.", "severity": 2}
{"drug1": "nicergoline", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with progesterone.", "severity": 2}
{"drug1": "quinapril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Clevidipine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Pramocaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with trimipramine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Propoxycaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Aliskiren.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with fluoxetine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with duloxetine.", "severity": 2}
{"drug1": "ketamine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with amitriptyline.", "severity": 2}
{"drug1": "ketamine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Tolcapone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Teriflunomide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Agomelatine.", "severity": 2}
{"drug1": "codeine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Cis-mdp.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Lofexidine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with mefenamic acid.", "severity": 2}
{"drug1": "chloroxine", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with paramethasone.", "severity": 2}
{"drug1": "procaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with NAPROXEN.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with thiothixene.", "severity": 2}
{"drug1": "epirizole", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Mometasone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with MELPERONE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with tenoxicam.", "severity": 2}
{"drug1": "pergolide", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with miconazole.", "severity": 2}
{"drug1": "selegiline", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with tretinoin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with amobarbital.", "severity": 2}
{"drug1": "pergolide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with nifedipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with isoxsuprine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with METAXALONE.", "severity": 2}
{"drug1": "pergolide", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with tacrolimus.", "severity": 2}
{"drug1": "epirizole", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with formestane.", "severity": 2}
{"drug1": "pergolide", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with ranitidine.", "severity": 2}
{"drug1": "epirizole", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with thioridazine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Difenoxin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Retigabine.", "severity": 2}
{"drug1": "baclofen", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with loratadine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with olanzapine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with levodopa.", "severity": 2}
{"drug1": "Torasemide", "drug2": "streptomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with streptomycin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with methadone.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with doxepin.", "severity": 2}
{"drug1": "zotepine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with clonazepam.", "severity": 2}
{"drug1": "zotepine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with promethazine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metronidazole is combined with ethanol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with DEZOCINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Methadyl acetate.", "severity": 2}
{"drug1": "celecoxib", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with diflunisal.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with glutethimide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Fluspirilene.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with sertraline.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with nimesulide.", "severity": 2}
{"drug1": "duloxetine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with sertraline.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Mephobarbital.", "severity": 2}
{"drug1": "ketorolac", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with nalbuphine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with sulpiride.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with oxazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with carisoprodol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with etizolam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with hydralazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with venlafaxine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with isoxsuprine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with dipyridamole.", "severity": 2}
{"drug1": "Halazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Hexobarbital.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with thiamylal.", "severity": 2}
{"drug1": "methadone", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with halothane.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with midazolam.", "severity": 2}
{"drug1": "clozapine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with tretinoin.", "severity": 2}
{"drug1": "clozapine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ethotoin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Fluspirilene.", "severity": 2}
{"drug1": "clemastine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with clidinium.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with homoharringtonine.", "severity": 2}
{"drug1": "etodolac", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with ketoprofen.", "severity": 2}
{"drug1": "epirizole", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Ciclesonide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with sulindac.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with formestane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Fluspirilene.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Desloratadine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with thiopental.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with efavirenz.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with ethosuximide.", "severity": 2}
{"drug1": "valsartan", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "terbutaline", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with oxymetazoline.", "severity": 2}
{"drug1": "quinacrine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinacrine is combined with dapsone.", "severity": 2}
{"drug1": "epinephrine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with metaproterenol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with penbutolol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "enflurane", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with cocaine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ESMOLOL.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with dipyridamole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Drospirenone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with betamethasone.", "severity": 2}
{"drug1": "Articaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "eperisone", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "amisulpride", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with zonisamide.", "severity": 2}
{"drug1": "scopolamine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with dibucaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with butorphanol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with budesonide.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with meclofenamic acid.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with amitriptyline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Tolcapone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Perospirone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Tasimelteon.", "severity": 2}
{"drug1": "diazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "loxapine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with sevoflurane.", "severity": 2}
{"drug1": "oxycodone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with amoxapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Pipamperone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with triamterene.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with isradipine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Olmesartan.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with budesonide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Risedronic acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Articaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with pargyline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Sitaxsentan.", "severity": 2}
{"drug1": "loxapine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Pipotiazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with methazolamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "captopril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Naftifine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with bromazepam.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Apremilast.", "severity": 2}
{"drug1": "nicergoline", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with prednisone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with dexamethasone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with astemizole.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Droxicam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with Pefloxacin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with triamterene.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Asenapine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with clidinium.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Vismodegib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Vismodegib.", "severity": 2}
{"drug1": "diflunisal", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with sumatriptan.", "severity": 2}
{"drug1": "methoxamine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with METAXALONE.", "severity": 2}
{"drug1": "manidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when manidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with thalidomide.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Eplerenone.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with methazolamide.", "severity": 2}
{"drug1": "enflurane", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with promethazine.", "severity": 2}
{"drug1": "Trospium", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with quinidine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with butorphanol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with selegiline.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with quinapril.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "naratriptan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with tiapride.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with topiramate.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with hydralazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with acetazolamide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with lidocaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with amisulpride.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with felbamate.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with norfloxacin.", "severity": 2}
{"drug1": "prazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with mecamylamine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Oxetacaine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with acemetacin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with amisulpride.", "severity": 2}
{"drug1": "acemetacin", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "dyphylline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyphylline is combined with formoterol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Clevidipine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with pirenzepine.", "severity": 2}
{"drug1": "buspirone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with nitrazepam.", "severity": 2}
{"drug1": "etizolam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Iloperidone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with suprofen.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Phenelzine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with alclofenac.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with clidinium.", "severity": 2}
{"drug1": "antipyrine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with paramethasone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ceritinib is combined with atorvastatin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with droperidol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Toloxatone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Pirlindole.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Eletriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Eletriptan.", "severity": 2}
{"drug1": "butamben", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with tizanidine.", "severity": 2}
{"drug1": "morphine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with amitriptyline.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with phenobarbital.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with Rosuvastatin.", "severity": 2}
{"drug1": "methysergide", "drug2": "Darunavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Darunavir.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with ibuprofen.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with methadone.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with fluvastatin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with thiamylal.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with bupropion.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with METAXALONE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with ketamine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with venlafaxine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolpidem is combined with Milnacipran.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with tetracycline.", "severity": 2}
{"drug1": "meperidine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with triprolidine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with SUFENTANIL.", "severity": 2}
{"drug1": "meperidine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with methocarbamol.", "severity": 2}
{"drug1": "meperidine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with spironolactone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with methazolamide.", "severity": 2}
{"drug1": "hexetidine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with eperisone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with nefazodone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with sertraline.", "severity": 2}
{"drug1": "halothane", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with chlorthalidone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Aliskiren.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with GUANFACINE.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with gabapentin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with acemetacin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with nisoldipine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "celecoxib", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with metaproterenol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with glutethimide.", "severity": 2}
{"drug1": "benztropine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with methscopolamine.", "severity": 2}
{"drug1": "dapsone", "drug2": "phenazopyridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with phenazopyridine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with diphenhydramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with NITROUS ACID.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Nepafenac.", "severity": 2}
{"drug1": "rasagiline", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with thioridazine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with benazepril.", "severity": 2}
{"drug1": "pimozide", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with baclofen.", "severity": 2}
{"drug1": "morphine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with enalapril.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with duloxetine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with pimozide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with sulindac.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "clomiphene", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomiphene is combined with atorvastatin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with chloroquine.", "severity": 2}
{"drug1": "pimozide", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with Enalaprilat.", "severity": 2}
{"drug1": "morphine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Iloperidone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with flunarizine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "thiothixene", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with fluoxetine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with nimesulide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with DESONIDE.", "severity": 2}
{"drug1": "promazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with fluvoxamine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with pravastatin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with niflumic acid.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with isoproterenol.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with DEZOCINE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with atenolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with zopiclone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with butalbital.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Milnacipran.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with captopril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with acebutolol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with mesalamine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Levocetirizine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Levocetirizine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Levetiracetam.", "severity": 2}
{"drug1": "felbamate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "linezolid", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with risperidone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with hydralazine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with Trovafloxacin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Fencamfamin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with resveratrol.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with Enalaprilat.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with equilin.", "severity": 2}
{"drug1": "tolazoline", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with terazosin.", "severity": 2}
{"drug1": "thiopental", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with atorvastatin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with equilin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with zonisamide.", "severity": 2}
{"drug1": "EDTA", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EDTA is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with tiagabine.", "severity": 2}
{"drug1": "quazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with doxepin.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with isradipine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with lidocaine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with nortriptyline.", "severity": 2}
{"drug1": "ketamine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with amoxapine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "methadone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with sulpiride.", "severity": 2}
{"drug1": "zonisamide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with sertraline.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with prazepam.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with amisulpride.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with methylprednisolone.", "severity": 2}
{"drug1": "enflurane", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "enalapril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with celecoxib.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with brotizolam.", "severity": 2}
{"drug1": "cetirizine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with tizanidine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with celiprolol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Potassium citrate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with risperidone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with meclizine.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SIMEPREVIR is combined with Temsirolimus.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with tetracaine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Remoxipride.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with loxapine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with methazolamide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with triazolam.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Mephobarbital.", "severity": 2}
{"drug1": "imipramine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nadolol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "methadone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with dyclonine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with fluocinonide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with labetalol.", "severity": 2}
{"drug1": "linezolid", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Fencamfamin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with doxazosin.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Retigabine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with olanzapine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with DEZOCINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Apremilast.", "severity": 2}
{"drug1": "lithium ion", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with METAXALONE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with metoclopramide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ibuprofen.", "severity": 2}
{"drug1": "paroxetine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with thiothixene.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Thioproperazine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with amoxapine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with resveratrol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with DEZOCINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with desipramine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Nabilone", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with atenolol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Etoricoxib.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Empagliflozin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with butamben.", "severity": 2}
{"drug1": "docetaxel", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with ifosfamide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with betamethasone.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with felbamate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "nefazodone", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with prednisone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with doxepin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with amcinonide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with pancuronium.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with sotalol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with norfloxacin.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with ethotoin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Flupentixol.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Levocetirizine.", "severity": 2}
{"drug1": "sulindac", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with alclofenac.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Ramelteon.", "severity": 2}
{"drug1": "leflunomide", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with flurandrenolide.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "promethazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with dexamethasone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with fleroxacin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with dapsone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Olopatadine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with formoterol.", "severity": 2}
{"drug1": "THYMOL", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with diltiazem.", "severity": 2}
{"drug1": "nefazodone", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with droperidol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Levetiracetam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with clomipramine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with isocarboxazid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with nimesulide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with DEZOCINE.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with phenmetrazine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with captopril.", "severity": 2}
{"drug1": "clonidine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with scopolamine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with acebutolol.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Trospium.", "severity": 2}
{"drug1": "methysergide", "drug2": "nelfinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nelfinavir.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with venlafaxine.", "severity": 2}
{"drug1": "methysergide", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with lovastatin.", "severity": 2}
{"drug1": "methysergide", "drug2": "indinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with indinavir.", "severity": 2}
{"drug1": "primidone", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with secobarbital.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with fenbufen.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with dyclonine.", "severity": 2}
{"drug1": "pargyline", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with metaproterenol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "promazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with HEROIN.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with trimipramine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with fenbufen.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "promazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Tolcapone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with moclobemide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "ethotoin", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with triamterene.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Fencamfamin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with methadone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with trandolapril.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with olanzapine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with alclofenac.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with loteprednol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with doxepin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with suprofen.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with methylphenidate.", "severity": 2}
{"drug1": "propranolol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with methazolamide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with cocaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with zopiclone.", "severity": 2}
{"drug1": "propantheline", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with methscopolamine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with ESMOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with quinidine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Canagliflozin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with promethazine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Normethadone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with mecamylamine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Droxicam.", "severity": 2}
{"drug1": "diflorasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Propacetamol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with butamben.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with promethazine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with methocarbamol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with triprolidine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with epirizole.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nicardipine.", "severity": 2}
{"drug1": "sulindac", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "sulindac", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Halobetasol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with efavirenz.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Melatonin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Normethadone.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "aspirin", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with celecoxib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with fosinopril.", "severity": 2}
{"drug1": "thalidomide", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with methyclothiazide.", "severity": 2}
{"drug1": "proparacaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with venlafaxine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with desipramine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with epirizole.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Aceclofenac.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with zaltoprofen.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with doxepin.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Levocetirizine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with dantrolene.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with hydromorphone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with atorvastatin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with budesonide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with efavirenz.", "severity": 2}
{"drug1": "flurazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with felbamate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with levodopa.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Melatonin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Milnacipran.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with chlorprothixene.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Aripiprazole.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with oxybutynin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with clonazepam.", "severity": 2}
{"drug1": "procaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "propofol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with lisinopril.", "severity": 2}
{"drug1": "Melatonin", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with clidinium.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with pilocarpine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with flurbiprofen.", "severity": 2}
{"drug1": "imipramine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with buspirone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with olanzapine.", "severity": 2}
{"drug1": "morphine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with clidinium.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with levodopa.", "severity": 2}
{"drug1": "rasagiline", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with methadone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with fexofenadine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Lornoxicam.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nadolol.", "severity": 2}
{"drug1": "propantheline", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Fesoterodine.", "severity": 2}
{"drug1": "loxapine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with flurazepam.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with butamben.", "severity": 2}
{"drug1": "loxapine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with tizanidine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Normethadone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Pipotiazine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with sertraline.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Oxetacaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with dantrolene.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Olopatadine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Pomalidomide.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with tizanidine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Aceclofenac.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Melatonin.", "severity": 2}
{"drug1": "papaverine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "amisulpride", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with trimipramine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Ticagrelor.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Lurasidone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with imipramine.", "severity": 2}
{"drug1": "propantheline", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with SUFENTANIL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with danazol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with promethazine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with clonazepam.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with ESMOLOL.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with trimipramine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with procaine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with Pefloxacin.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "hexetidine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with nilvadipine.", "severity": 2}
{"drug1": "medrysone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with memantine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with nadolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "adenosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with adenosine.", "severity": 2}
{"drug1": "medrysone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with benzocaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with tetracaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Perospirone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with dexamethasone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Desloratadine.", "severity": 2}
{"drug1": "codeine", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with furazolidone.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "loxapine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with benzocaine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Sacubitril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Sacubitril.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with nefazodone.", "severity": 2}
{"drug1": "biperiden", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with pancuronium.", "severity": 2}
{"drug1": "fenbufen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with flunisolide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Mirabegron.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Clevidipine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with physostigmine.", "severity": 2}
{"drug1": "biperiden", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "bepridil", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with clozapine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with rivastigmine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with methylprednisolone.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ADAPALENE.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with clenbuterol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with primidone.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with quetiapine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with nitroglycerin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Phenelzine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "procaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Tolcapone.", "severity": 2}
{"drug1": "procaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with amitriptyline.", "severity": 2}
{"drug1": "ramipril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with hydralazine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Butethal", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Flibanserin.", "severity": 2}
{"drug1": "estazolam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with GUANFACINE.", "severity": 2}
{"drug1": "citalopram", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Milnacipran.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with ibuprofen.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with MELPERONE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Clevidipine.", "severity": 2}
{"drug1": "procaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with ZILEUTON.", "severity": 2}
{"drug1": "dyclonine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with HEROIN.", "severity": 2}
{"drug1": "clozapine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with methylphenidate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with lithium ion.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Ketobemidone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with AMILORIDE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ethosuximide.", "severity": 2}
{"drug1": "pargyline", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with isoetharine.", "severity": 2}
{"drug1": "butalbital", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with phenytoin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with thiopental.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nefazodone.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Tixocortol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with irbesartan.", "severity": 2}
{"drug1": "Nabilone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Loxoprofen.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with tiagabine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with cocaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with ondansetron.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Droxicam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "temozolomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with temozolomide.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with vigabatrin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with CLONIXIN.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with clonazepam.", "severity": 2}
{"drug1": "halothane", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Phenelzine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with flunitrazepam.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with zotepine.", "severity": 2}
{"drug1": "benazepril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with resveratrol.", "severity": 2}
{"drug1": "halothane", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with DEZOCINE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with baclofen.", "severity": 2}
{"drug1": "halothane", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nadolol.", "severity": 2}
{"drug1": "bepridil", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with bupivacaine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Ropivacaine.", "severity": 2}
{"drug1": "bepridil", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with morphine.", "severity": 2}
{"drug1": "aspirin", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with clemastine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with niflumic acid.", "severity": 2}
{"drug1": "Butethal", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Aceprometazine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Tixocortol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Torasemide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with Milnacipran.", "severity": 2}
{"drug1": "valsartan", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with floctafenine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Olsalazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Normethadone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with propofol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Fluspirilene.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "prednisone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with nalidixic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Ethylmorphine.", "severity": 2}
{"drug1": "prednisone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with malathion.", "severity": 2}
{"drug1": "thiamylal", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with halothane.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with thiopental.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Salsalate.", "severity": 2}
{"drug1": "methazolamide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Risedronic acid.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with butalbital.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with nefazodone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with AMILORIDE.", "severity": 2}
{"drug1": "pimozide", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with nitrous oxide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with suprofen.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Risedronic acid.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with irbesartan.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Tolcapone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with amitriptyline.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Pipotiazine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with propoxyphene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Ramelteon.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with levodopa.", "severity": 2}
{"drug1": "Micafungin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with eperisone.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with eperisone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with tizanidine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with trimipramine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with sertraline.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with ambenonium.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Pizotifen.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with flunarizine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with mesalamine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with butalbital.", "severity": 2}
{"drug1": "Quinine", "drug2": "Halofantrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Quinine is combined with Halofantrine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with diazoxide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with KETAZOLAM.", "severity": 2}
{"drug1": "meperidine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with quazepam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with prazepam.", "severity": 2}
{"drug1": "meperidine", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with clorazepate.", "severity": 2}
{"drug1": "enflurane", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with KETAZOLAM.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with mefloquine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with propoxyphene.", "severity": 2}
{"drug1": "amifostine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with dyclonine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with meclizine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with brotizolam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "hydroxyzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with hydroxyzine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with cetirizine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Pomalidomide.", "severity": 2}
{"drug1": "benazepril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with zaltoprofen.", "severity": 2}
{"drug1": "dibucaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with protriptyline.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with pentazocine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Levomilnacipran.", "severity": 2}
{"drug1": "bromazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with pentazocine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Lomitapide.", "severity": 2}
{"drug1": "procyclidine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with methscopolamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Frovatriptan.", "severity": 2}
{"drug1": "meperidine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "meperidine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with gabapentin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Canagliflozin.", "severity": 2}
{"drug1": "valsartan", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with spironolactone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with OLODATEROL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with METAXALONE.", "severity": 2}
{"drug1": "baclofen", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with paroxetine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "losartan", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with CLONIXIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with butalbital.", "severity": 2}
{"drug1": "losartan", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with tolfenamic acid.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with carisoprodol.", "severity": 2}
{"drug1": "losartan", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Droxicam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with sulpiride.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nimodipine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Lofexidine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with maprotiline.", "severity": 2}
{"drug1": "Darunavir", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Darunavir is combined with mecamylamine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Milnacipran.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Articaine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "prazosin", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with terazosin.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with butalbital.", "severity": 2}
{"drug1": "meperidine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Agomelatine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Aliskiren.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Loxoprofen.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with thalidomide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Droxicam.", "severity": 2}
{"drug1": "difluprednate", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with malathion.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with butamben.", "severity": 2}
{"drug1": "Salsalate", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with CLONIXIN.", "severity": 2}
{"drug1": "difluprednate", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with nalidixic acid.", "severity": 2}
{"drug1": "alclofenac", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with desoximetasone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with proparacaine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with diflorasone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with methoxyflurane.", "severity": 2}
{"drug1": "enflurane", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Articaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with tetracaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with MELPERONE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with terazosin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with fenbufen.", "severity": 2}
{"drug1": "Artemether", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with nisoldipine.", "severity": 2}
{"drug1": "etodolac", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with paramethasone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Fludarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Fludarabine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Levomilnacipran.", "severity": 2}
{"drug1": "pentazocine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with isoflurane.", "severity": 2}
{"drug1": "methazolamide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with quetiapine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with Calcipotriol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Fencamfamin.", "severity": 2}
{"drug1": "topiramate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Difenoxin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Pizotifen.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with DEZOCINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Droxicam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ketoprofen.", "severity": 2}
{"drug1": "desipramine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Retigabine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Flibanserin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Loxoprofen.", "severity": 2}
{"drug1": "alclometasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "diltiazem", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with nisoldipine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Tianeptine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with baclofen.", "severity": 2}
{"drug1": "doxepin", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with betamethasone.", "severity": 2}
{"drug1": "sertraline", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Aripiprazole.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Indacaterol.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with fexofenadine.", "severity": 2}
{"drug1": "cocaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with glutethimide.", "severity": 2}
{"drug1": "felbamate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with clonazepam.", "severity": 2}
{"drug1": "felbamate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with promethazine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Loxoprofen.", "severity": 2}
{"drug1": "temazepam", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with butorphanol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with epirizole.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with tolfenamic acid.", "severity": 2}
{"drug1": "resveratrol", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with budesonide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Droxicam.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with felbamate.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with CLONIXIN.", "severity": 2}
{"drug1": "ketorolac", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with NAPROXEN.", "severity": 2}
{"drug1": "pergolide", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Pramocaine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Milnacipran.", "severity": 2}
{"drug1": "methysergide", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with mirtazapine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Aceprometazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with topiramate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with felodipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with resveratrol.", "severity": 2}
{"drug1": "suprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with MOLINDONE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Propoxycaine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Olopatadine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with diltiazem.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "minocycline", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minocycline is combined with ADAPALENE.", "severity": 2}
{"drug1": "morphine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Eprosartan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with amisulpride.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Ethylmorphine.", "severity": 2}
{"drug1": "morphine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Flupentixol.", "severity": 2}
{"drug1": "pimozide", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Fluspirilene.", "severity": 2}
{"drug1": "methadone", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with loxapine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with clemastine.", "severity": 2}
{"drug1": "methadone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methadone", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Eszopiclone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with terazosin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with meperidine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Masoprocol.", "severity": 2}
{"drug1": "pergolide", "drug2": "josamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with josamycin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with trimipramine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with glutethimide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with trimipramine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with procaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with acebutolol.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Methadyl acetate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with lidocaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with minoxidil.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Iloperidone.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Clevidipine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with irbesartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with chlorothiazide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with brotizolam.", "severity": 2}
{"drug1": "diazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Potassium citrate.", "severity": 2}
{"drug1": "zaleplon", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with zotepine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with etizolam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with MELPERONE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with metyrapone.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with glyburide.", "severity": 2}
{"drug1": "cocaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Milnacipran.", "severity": 2}
{"drug1": "prazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with azelastine.", "severity": 2}
{"drug1": "diazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with maprotiline.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Iloperidone.", "severity": 2}
{"drug1": "quazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with glutethimide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with VERAPAMIL.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with METAXALONE.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with clenbuterol.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with acemetacin.", "severity": 2}
{"drug1": "furosemide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with methazolamide.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Bambuterol.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with desipramine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Pipamperone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with topiramate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with indomethacin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with amoxapine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with nortriptyline.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with propoxyphene.", "severity": 2}
{"drug1": "selegiline", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "butamben", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Pizotifen.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "buspirone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with bupivacaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Ropivacaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with enflurane.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with clonazepam.", "severity": 2}
{"drug1": "buspirone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Etomidate.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with sotalol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Melatonin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with isoetharine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with ambenonium.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "nicergoline", "drug2": "SIMEPREVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with benzocaine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Lercanidipine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with vigabatrin.", "severity": 2}
{"drug1": "quinapril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with ibuprofen.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with tiapride.", "severity": 2}
{"drug1": "diflunisal", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with oxymorphone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with paramethasone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nisoldipine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with mesoridazine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with dipyridamole.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with apraclonidine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with HEROIN.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Ciclesonide.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with paroxetine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Oxetacaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Flupentixol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with rapamycin.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with decamethonium.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with ciprofloxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with hydrocortisone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with METAXALONE.", "severity": 2}
{"drug1": "Articaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with clonidine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with amisulpride.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with efavirenz.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Levocetirizine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with levodopa.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with zonisamide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with irbesartan.", "severity": 2}
{"drug1": "biperiden", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with methadone.", "severity": 2}
{"drug1": "reserpine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with felodipine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Flupentixol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with trimipramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Mersalyl.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Tasimelteon.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cobicistat is combined with toremifene.", "severity": 2}
{"drug1": "nicergoline", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with alprazolam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with nisoldipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Fospropofol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with desoximetasone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Echothiophate.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with norfloxacin.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Olsalazine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with CLONIXIN.", "severity": 2}
{"drug1": "nabumetone", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with loteprednol.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Droxicam.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Loxoprofen.", "severity": 2}
{"drug1": "haloprogin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Milnacipran.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with bromazepam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with perphenazine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with levorphanol.", "severity": 2}
{"drug1": "doxepin", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with moclobemide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "methadone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Ramelteon.", "severity": 2}
{"drug1": "enflurane", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with dantrolene.", "severity": 2}
{"drug1": "methadone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with levorphanol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Fencamfamin.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "Melatonin", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with clonidine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Ketobemidone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Mephobarbital.", "severity": 2}
{"drug1": "meperidine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Normethadone.", "severity": 2}
{"drug1": "enalapril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ketoprofen.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with formestane.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Flibanserin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "carprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with acemetacin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with fluvoxamine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Asenapine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Empagliflozin.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Metipranolol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with fexofenadine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with rivastigmine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with zotepine.", "severity": 2}
{"drug1": "Quinine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Quinine is combined with dapsone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with primidone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "doxylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with doxylamine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with quetiapine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Cis-mdp.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with haloperidol.", "severity": 2}
{"drug1": "promazine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Butethal.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with benzocaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Nitroprusside.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with bumetanide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with vigabatrin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "promazine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with amobarbital.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with furosemide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with tizanidine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with chlorothiazide.", "severity": 2}
{"drug1": "atenolol", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with fosinopril.", "severity": 2}
{"drug1": "trazodone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with baclofen.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with chlormezanone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with bumetanide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with chlorothiazide.", "severity": 2}
{"drug1": "temazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with trazodone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with butorphanol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with olanzapine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Clevidipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with butamben.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Etoricoxib.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with omeprazole.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with Apixaban.", "severity": 2}
{"drug1": "reserpine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with cilazapril.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with carisoprodol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfadiazine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with maprotiline.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with clonazepam.", "severity": 2}
{"drug1": "HEROIN", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with promethazine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Milnacipran.", "severity": 2}
{"drug1": "Perospirone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with carisoprodol.", "severity": 2}
{"drug1": "epirizole", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with fludrocortisone.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "leflunomide", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with fenbufen.", "severity": 2}
{"drug1": "atenolol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with nitroglycerin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with D-mannitol.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with decamethonium.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Atracurium besylate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with methylprednisolone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with epoprostenol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with clomipramine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with bepridil.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with isocarboxazid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with cetirizine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Thioproperazine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with efavirenz.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with tiapride.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with atorvastatin.", "severity": 2}
{"drug1": "trazodone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with oxprenolol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "trazodone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "codeine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Efonidipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "clozapine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with quetiapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ketamine.", "severity": 2}
{"drug1": "furosemide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "quazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with triprolidine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Flupentixol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Aliskiren.", "severity": 2}
{"drug1": "quazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with paroxetine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with furosemide.", "severity": 2}
{"drug1": "furosemide", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with doxorubicin.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with flunarizine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with felbamate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with captopril.", "severity": 2}
{"drug1": "linezolid", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with thioridazine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with acebutolol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with clomipramine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Iloperidone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Mometasone.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with rosiglitazone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Levetiracetam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nimesulide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Indacaterol.", "severity": 2}
{"drug1": "felodipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with nadolol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ethotoin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with dantrolene.", "severity": 2}
{"drug1": "procaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with tizanidine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with timolol.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with methyldopa.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with betamethasone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Telmisartan.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with apraclonidine.", "severity": 2}
{"drug1": "tiapride", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Fosphenytoin.", "severity": 2}
{"drug1": "valsartan", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Spirapril.", "severity": 2}
{"drug1": "zotepine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "propantheline", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Mirabegron.", "severity": 2}
{"drug1": "butorphanol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "morphine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with DEZOCINE.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with oxybutynin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with triazolam.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with protriptyline.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with DEZOCINE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Sacubitril.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ketorolac.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Icatibant.", "severity": 2}
{"drug1": "THYMOL", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with gabapentin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with dipyridamole.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Tasimelteon.", "severity": 2}
{"drug1": "docetaxel", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with streptozocin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with chlorprothixene.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Etidronic acid.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Escitalopram.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Salsalate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Iloperidone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with flunisolide.", "severity": 2}
{"drug1": "benztropine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Tapentadol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dronedarone is combined with Flibanserin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "triprolidine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Metixene.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Aceclofenac.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with SERATRODAST.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with phentolamine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with furosemide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with tizanidine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with prochlorperazine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with amcinonide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with thalidomide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Ramelteon.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "triamterene", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with bumetanide.", "severity": 2}
{"drug1": "triamterene", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with chlorothiazide.", "severity": 2}
{"drug1": "triamterene", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with quinapril.", "severity": 2}
{"drug1": "triamterene", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with floctafenine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Tixocortol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with antipyrine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with ethosuximide.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Tasimelteon.", "severity": 2}
{"drug1": "procarbazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with olanzapine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with methadone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with doxepin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with midazolam.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Apremilast.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Teriflunomide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with acebutolol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with METAXALONE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with methyclothiazide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with prednisone.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Nepafenac.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Propoxycaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Clofarabine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Perospirone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Eletriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Eletriptan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with citalopram.", "severity": 2}
{"drug1": "Asenapine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with tetracaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with triflupromazine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with felbamate.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with prazepam.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Pregabalin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with nimodipine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with ondansetron.", "severity": 2}
{"drug1": "prazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with tiagabine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with zonisamide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with amcinonide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with desoximetasone.", "severity": 2}
{"drug1": "caffeine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when caffeine is combined with formoterol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Thioproperazine is combined with methylphenidate.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with tiapride.", "severity": 2}
{"drug1": "ramipril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with floctafenine.", "severity": 2}
{"drug1": "isradipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nilvadipine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Etidocaine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spiramycin is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "naratriptan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with desipramine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with salicylamide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "valsartan", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with tolmetin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Pizotifen.", "severity": 2}
{"drug1": "rapamycin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with lisinopril.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with GUANFACINE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with METAXALONE.", "severity": 2}
{"drug1": "reserpine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with dipyridamole.", "severity": 2}
{"drug1": "bepridil", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with efavirenz.", "severity": 2}
{"drug1": "bepridil", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with fluvastatin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with loratadine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with nicotine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with Cevimeline.", "severity": 2}
{"drug1": "nabumetone", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with prednisone.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Halobetasol.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with tiagabine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with ondansetron.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with amisulpride.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with zonisamide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with metoprolol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with meclofenamic acid.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Canagliflozin.", "severity": 2}
{"drug1": "valsartan", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with betaxolol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with diazoxide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with risperidone.", "severity": 2}
{"drug1": "butalbital", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with nortriptyline.", "severity": 2}
{"drug1": "butalbital", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with amoxapine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with isradipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with prilocaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with proparacaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Halazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ALFENTANIL.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Rotigotine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with duloxetine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with indapamide.", "severity": 2}
{"drug1": "sulindac", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with dexamethasone.", "severity": 2}
{"drug1": "enalapril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Bretylium.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with docetaxel.", "severity": 2}
{"drug1": "carvedilol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with alclometasone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with alclometasone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ximelagatran is combined with Deferasirox.", "severity": 2}
{"drug1": "meprobamate", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with scopolamine.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gliquidone is combined with ethanol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Dapagliflozin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with trazodone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with mecamylamine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Difenoxin.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with prednisone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Agomelatine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Fencamfamin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with metaproterenol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Canrenoic acid.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with brotizolam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Conivaptan.", "severity": 2}
{"drug1": "naratriptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with reserpine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Ethylmorphine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "zaleplon", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with pimozide.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with sertraline.", "severity": 2}
{"drug1": "losartan", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with hydralazine.", "severity": 2}
{"drug1": "clozapine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with fenoldopam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with oxprenolol.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with pancuronium.", "severity": 2}
{"drug1": "clozapine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with prednisone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Tasimelteon.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with felodipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Paliperidone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with irbesartan.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with chlorprothixene.", "severity": 2}
{"drug1": "pergolide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "bepridil", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Dapagliflozin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with clidinium.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with levodopa.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with perphenazine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with meclizine.", "severity": 2}
{"drug1": "loxapine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with butalbital.", "severity": 2}
{"drug1": "levorphanol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with scopolamine.", "severity": 2}
{"drug1": "methadone", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ALFENTANIL.", "severity": 2}
{"drug1": "levorphanol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with D-mannitol.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with aspirin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with droperidol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with droperidol.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with clidinium.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with amisulpride.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with procaine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Perospirone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with diflunisal.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with chlorpheniramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with epoprostenol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with clomipramine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Melatonin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with isocarboxazid.", "severity": 2}
{"drug1": "pergolide", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with nitric oxide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with clonazepam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with promethazine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with prilocaine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "prednisone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with physostigmine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with ethotoin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with methyldopa.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with clomipramine.", "severity": 2}
{"drug1": "altretamine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when altretamine is combined with clozapine.", "severity": 2}
{"drug1": "codeine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with triprolidine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Efonidipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Levocetirizine.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "ceftriaxone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium acetate is combined with ceftriaxone.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Lacidipine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Telmisartan.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Azelnidipine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with apraclonidine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with cilnidipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with fluoxetine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Phenelzine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with duloxetine.", "severity": 2}
{"drug1": "ketamine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with imipramine.", "severity": 2}
{"drug1": "ketamine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with loratadine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with dipyridamole.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "clorazepate", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with METAXALONE.", "severity": 2}
{"drug1": "methadone", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with naratriptan.", "severity": 2}
{"drug1": "methysergide", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with fluvastatin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Normethadone", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Empagliflozin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Sacubitril.", "severity": 2}
{"drug1": "valsartan", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with nimesulide.", "severity": 2}
{"drug1": "halothane", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Canagliflozin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Olopatadine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with felbamate.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with leflunomide.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetaminophen is combined with NITROUS ACID.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with ethosuximide.", "severity": 2}
{"drug1": "triamterene", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with D-mannitol.", "severity": 2}
{"drug1": "Artemether", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Risedronic acid.", "severity": 2}
{"drug1": "cilazapril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with tenoxicam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Efonidipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with fluoxetine.", "severity": 2}
{"drug1": "propantheline", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Ramelteon.", "severity": 2}
{"drug1": "cilazapril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with ketorolac.", "severity": 2}
{"drug1": "ketamine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "meclizine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Flibanserin.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Azelnidipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with cilnidipine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Paliperidone.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with desipramine.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Lacidipine.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with manidipine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with fleroxacin.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with butorphanol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with fexofenadine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Aliskiren.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "procaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with triprolidine.", "severity": 2}
{"drug1": "flutamide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flutamide is combined with prilocaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with isoflurane.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glimepiride is combined with Carbocisteine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with benazepril.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with selegiline.", "severity": 2}
{"drug1": "risperidone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with butamben.", "severity": 2}
{"drug1": "alprazolam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with prilocaine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with nimodipine.", "severity": 2}
{"drug1": "quinapril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ibuprofen.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with chloral hydrate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Salsalate.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with bumetanide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with rivastigmine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clenbuterol is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Retigabine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Cis-mdp.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with sevoflurane.", "severity": 2}
{"drug1": "betaxolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Fluspirilene.", "severity": 2}
{"drug1": "dantrolene", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with clomipramine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Agomelatine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Propoxycaine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Pramocaine.", "severity": 2}
{"drug1": "enalapril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ZILEUTON.", "severity": 2}
{"drug1": "propantheline", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with levorphanol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with flunarizine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with haloperidol.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Desloratadine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with mepivacaine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with DEZOCINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with clomipramine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with triprolidine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with isocarboxazid.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with spironolactone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with methocarbamol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with selegiline.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Articaine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with indomethacin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with apraclonidine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with fluvoxamine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Levetiracetam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Droxicam", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with homoharringtonine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ritodrine.", "severity": 2}
{"drug1": "timolol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "timolol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with chlorothiazide.", "severity": 2}
{"drug1": "timolol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with quinapril.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Ciclesonide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Desloratadine.", "severity": 2}
{"drug1": "propofol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Difenoxin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with mepivacaine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Ethylmorphine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with scopolamine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Rosuvastatin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with timolol.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with acemetacin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Articaine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with leflunomide.", "severity": 2}
{"drug1": "methadone", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with SERATRODAST.", "severity": 2}
{"drug1": "isoflurane", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with trifluoperazine.", "severity": 2}
{"drug1": "propofol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with tetracaine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with indapamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with quetiapine.", "severity": 2}
{"drug1": "temazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with proparacaine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "temazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Halazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with bromazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with ALFENTANIL.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with pyridostigmine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Escitalopram.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with olanzapine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with methadone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with tenoxicam.", "severity": 2}
{"drug1": "pyrimethamine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyrimethamine is combined with dapsone.", "severity": 2}
{"drug1": "meperidine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with acetazolamide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with nabumetone.", "severity": 2}
{"drug1": "baclofen", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Levocetirizine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with ketorolac.", "severity": 2}
{"drug1": "cabergoline", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with mitoxantrone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with tranylcypromine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with lomustine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with bromocriptine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with tretinoin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with DESONIDE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with paramethasone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Paliperidone.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with paroxetine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Tasimelteon.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with salicylamide.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Torasemide.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with zotepine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with MELPERONE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Ethylmorphine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Zoledronic acid.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Fencamfamin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with chlorpheniramine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with eperisone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Etidocaine.", "severity": 2}
{"drug1": "vincristine", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vincristine is combined with mitomycin C.", "severity": 2}
{"drug1": "clomiphene", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomiphene is combined with Ospemifene.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with trifluoperazine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Fospropofol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with baclofen.", "severity": 2}
{"drug1": "pimozide", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with thiamylal.", "severity": 2}
{"drug1": "pimozide", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with halothane.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Articaine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with vigabatrin.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "cetirizine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with desipramine.", "severity": 2}
{"drug1": "butamben", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with butalbital.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "Halazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Pipamperone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "clorazepate", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with isoflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with tranylcypromine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with prilocaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Difenoxin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with vigabatrin.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Fluprednidene.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Difenoxin.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with amoxapine.", "severity": 2}
{"drug1": "sertraline", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with desipramine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Isometheptene.", "severity": 2}
{"drug1": "minoxidil", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Limaprost", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with rosiglitazone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Deferasirox.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with tetracaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with mesoridazine.", "severity": 2}
{"drug1": "indapamide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with GUANFACINE.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clenbuterol is combined with nylidrin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with paroxetine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Pizotifen.", "severity": 2}
{"drug1": "clozapine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Naftifine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Telmisartan.", "severity": 2}
{"drug1": "clozapine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with felodipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with methyldopa.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with clomiphene.", "severity": 2}
{"drug1": "doxepin", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Salmeterol.", "severity": 2}
{"drug1": "alclofenac", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with flumethasone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Lormetazepam.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with vigabatrin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Fospropofol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Spirapril.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Normethadone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with clonidine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with pyridostigmine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Nebivolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with triamterene.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Tasimelteon.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "gabapentin", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Levetiracetam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with bromocriptine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Ramelteon.", "severity": 2}
{"drug1": "benazepril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with carprofen.", "severity": 2}
{"drug1": "Tramadol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with DEZOCINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "terconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with manidipine.", "severity": 2}
{"drug1": "butamben", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with chlorpheniramine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with phenytoin.", "severity": 2}
{"drug1": "terconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "terconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Benidipine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with D-mannitol.", "severity": 2}
{"drug1": "terconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with mecamylamine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with trazodone.", "severity": 2}
{"drug1": "pergolide", "drug2": "roxithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with roxithromycin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with flunisolide.", "severity": 2}
{"drug1": "pergolide", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with etoposide.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PRIMAQUINE is combined with atorvastatin.", "severity": 2}
{"drug1": "codeine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with glutethimide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with NICORANDIL.", "severity": 2}
{"drug1": "trandolapril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with dipyridamole.", "severity": 2}
{"drug1": "butabarbital", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with lidocaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with clemastine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with venlafaxine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Indacaterol.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with papaverine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with maprotiline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with lovastatin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "ketamine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with levodopa.", "severity": 2}
{"drug1": "thioridazine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with furosemide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Phenelzine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nelfinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with nelfinavir.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with atenolol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with pravastatin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with metoclopramide.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Nitroprusside.", "severity": 2}
{"drug1": "olanzapine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Ketobemidone.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Trospium.", "severity": 2}
{"drug1": "midazolam", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with SUFENTANIL.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with sparfloxacin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with benazepril.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with sulfasalazine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with isoflurane.", "severity": 2}
{"drug1": "butabarbital", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with tranylcypromine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with prilocaine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Isometheptene.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Olopatadine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with furosemide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with tizanidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with zaleplon.", "severity": 2}
{"drug1": "doxazosin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with selegiline.", "severity": 2}
{"drug1": "reserpine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with amitriptyline.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Fluprednidene.", "severity": 2}
{"drug1": "epirizole", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with loteprednol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Sorafenib.", "severity": 2}
{"drug1": "phentolamine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with fosinopril.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with ethotoin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with oxymorphone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with protriptyline.", "severity": 2}
{"drug1": "suprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with zopiclone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "morphine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ESMOLOL.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Rotigotine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remikiren is combined with meperidine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with paroxetine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with terazosin.", "severity": 2}
{"drug1": "sulindac", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Salsalate.", "severity": 2}
{"drug1": "Melatonin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "clonazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with diazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with clindamycin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with benazepril.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Tapentadol.", "severity": 2}
{"drug1": "trazodone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with amisulpride.", "severity": 2}
{"drug1": "benazepril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with fenbufen.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with clonidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with bumetanide.", "severity": 2}
{"drug1": "trazodone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Levocetirizine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with tiapride.", "severity": 2}
{"drug1": "benazepril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with procarbazine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with isoxsuprine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Naftifine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Loxoprofen.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Metipranolol.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Gatifloxacin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with memantine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "benazepril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with oxybutynin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "lomefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with lomefloxacin.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with methyclothiazide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "actinomycin D", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with actinomycin D.", "severity": 2}
{"drug1": "propranolol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with quinapril.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with triprolidine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Apremilast.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Lumiracoxib.", "severity": 2}
{"drug1": "fenbufen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with sevoflurane.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Estrone sulfate.", "severity": 2}
{"drug1": "reserpine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Perospirone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with furazolidone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Dasatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Dasatinib.", "severity": 2}
{"drug1": "glutethimide", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with etizolam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Teriflunomide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Articaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Melatonin.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Pramocaine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with desoximetasone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with tolmetin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with floctafenine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with amitriptyline.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Tolcapone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Nabilone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Enalaprilat.", "severity": 2}
{"drug1": "alprazolam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with thioridazine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with tolfenamic acid.", "severity": 2}
{"drug1": "glutethimide", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dacarbazine is combined with leflunomide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with oxaprozin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with sotalol.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with topiramate.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with bepridil.", "severity": 2}
{"drug1": "nicergoline", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with docetaxel.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with tolterodine.", "severity": 2}
{"drug1": "reserpine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Etoricoxib.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with ketamine.", "severity": 2}
{"drug1": "captopril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with quetiapine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with lisinopril.", "severity": 2}
{"drug1": "eperisone", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with fluvastatin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with halothane.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with chloral hydrate.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with bepridil.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with triamterene.", "severity": 2}
{"drug1": "eperisone", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with Rosuvastatin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with rasagiline.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with methyclothiazide.", "severity": 2}
{"drug1": "midazolam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Pipamperone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with duloxetine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Olopatadine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with fluoxetine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Pomalidomide.", "severity": 2}
{"drug1": "methysergide", "drug2": "Dasatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Dasatinib.", "severity": 2}
{"drug1": "Butethal", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Hexobarbital.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with prilocaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Lapatinib.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "methadone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nilvadipine.", "severity": 2}
{"drug1": "propofol", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with zaleplon.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with tenoxicam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with oxprenolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with clonazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with promethazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with polythiazide.", "severity": 2}
{"drug1": "ethanol", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Toloxatone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with prazepam.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Clofarabine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with celiprolol.", "severity": 2}
{"drug1": "imipramine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with furosemide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with MELPERONE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with HEROIN.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with chlorthalidone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Methadyl acetate.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with buprenorphine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with zotepine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Propoxycaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with ethchlorvynol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Pramocaine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Levobupivacaine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Zoledronic acid.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "hydroxyurea", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with hydroxyurea.", "severity": 2}
{"drug1": "levorphanol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with baclofen.", "severity": 2}
{"drug1": "midazolam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with fludiazepam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Vilazodone.", "severity": 2}
{"drug1": "tiapride", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with ethotoin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Aceclofenac.", "severity": 2}
{"drug1": "clidinium", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Levetiracetam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with baclofen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with ketoprofen.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with epinephrine.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with Tasimelteon.", "severity": 2}
{"drug1": "primidone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with quetiapine.", "severity": 2}
{"drug1": "probenecid", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when probenecid is combined with bumetanide.", "severity": 2}
{"drug1": "suprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with haloperidol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with ketamine.", "severity": 2}
{"drug1": "amifostine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "efavirenz", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with CYCLIZINE.", "severity": 2}
{"drug1": "amifostine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "amifostine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Eplerenone.", "severity": 2}
{"drug1": "amifostine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with methazolamide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with isoxsuprine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with meclofenamic acid.", "severity": 2}
{"drug1": "losartan", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with atorvastatin.", "severity": 2}
{"drug1": "methysergide", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Temsirolimus.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Fospropofol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with ROSOXACIN.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with NICORANDIL.", "severity": 2}
{"drug1": "nadolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Zoledronic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zoledronic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with pilocarpine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with reserpine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Milnacipran.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with scopolamine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with prazepam.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with desoximetasone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with fenbufen.", "severity": 2}
{"drug1": "tioconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Fluspirilene.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with nimodipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Tolcapone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with D-mannitol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Nitroprusside.", "severity": 2}
{"drug1": "proparacaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "rasagiline", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with tizanidine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Varenicline.", "severity": 2}
{"drug1": "thiopental", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Halazepam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "morphine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Ropivacaine.", "severity": 2}
{"drug1": "butamben", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Olopatadine.", "severity": 2}
{"drug1": "trazodone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "morphine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Etomidate.", "severity": 2}
{"drug1": "codeine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with etizolam.", "severity": 2}
{"drug1": "sulindac", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with tolfenamic acid.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Hexobarbital.", "severity": 2}
{"drug1": "procaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with paroxetine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Droxicam.", "severity": 2}
{"drug1": "sulindac", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Loxoprofen.", "severity": 2}
{"drug1": "oxycodone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with amobarbital.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Butethal.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Flibanserin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with buspirone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with tizanidine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with oxycodone.", "severity": 2}
{"drug1": "promazine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with gabapentin.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with Olsalazine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Iloperidone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with felbamate.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "trazodone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with carisoprodol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with apraclonidine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with formestane.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with sparfloxacin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with MOLINDONE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Levocetirizine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with acemetacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with diflorasone.", "severity": 2}
{"drug1": "morphine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with D-mannitol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with imipramine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "meprobamate", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with loratadine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with meperidine.", "severity": 2}
{"drug1": "tiapride", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with clemastine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with trimipramine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Demecarium.", "severity": 2}
{"drug1": "Icatibant", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with haloperidol.", "severity": 2}
{"drug1": "tiapride", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with desipramine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Cyamemazine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with orphenadrine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pramocaine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with butorphanol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with quinapril.", "severity": 2}
{"drug1": "Normethadone", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with potassium ion.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with bumetanide.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with celecoxib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Articaine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Perampanel", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with sertraline.", "severity": 2}
{"drug1": "betamethasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Ketobemidone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Normethadone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with MELPERONE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with zotepine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with fludrocortisone.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with HEROIN.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Levetiracetam.", "severity": 2}
{"drug1": "HEROIN", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with fludiazepam.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Torasemide.", "severity": 2}
{"drug1": "nadolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Metipranolol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with nitroglycerin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with nicotine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with cetirizine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Naftifine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Risedronic acid.", "severity": 2}
{"drug1": "clonidine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with METAXALONE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Fospropofol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with celecoxib.", "severity": 2}
{"drug1": "irbesartan", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with mycophenolic acid.", "severity": 2}
{"drug1": "risperidone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with zotepine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with MELPERONE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Lumiracoxib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "vindesine", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vindesine is combined with mitomycin C.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Etidocaine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Cis-mdp.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Ropivacaine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Nebivolol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Etomidate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with mecamylamine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Escitalopram.", "severity": 2}
{"drug1": "dibucaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Tolcapone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "enalapril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Lornoxicam.", "severity": 2}
{"drug1": "enalapril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with nifedipine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with chlormezanone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with fluocinonide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "butabarbital", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with triflupromazine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Pipotiazine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with sevoflurane.", "severity": 2}
{"drug1": "timolol", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with propranolol.", "severity": 2}
{"drug1": "propofol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with atorvastatin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with spironolactone.", "severity": 2}
{"drug1": "buspirone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with fludiazepam.", "severity": 2}
{"drug1": "melphalan", "drug2": "carmustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when melphalan is combined with carmustine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with antipyrine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with flumethasone.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with ethotoin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with tranylcypromine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with butamben.", "severity": 2}
{"drug1": "zaleplon", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with prilocaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with enalapril.", "severity": 2}
{"drug1": "bepridil", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with nifedipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with trandolapril.", "severity": 2}
{"drug1": "isoflurane", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with quinapril.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Pizotifen.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Milnacipran.", "severity": 2}
{"drug1": "zotepine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with clomipramine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with fluvastatin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with CARTEOLOL.", "severity": 2}
{"drug1": "risperidone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Olopatadine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with niflumic acid.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with sulpiride.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Metipranolol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with selegiline.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Pomalidomide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with etizolam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with protriptyline.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "metaraminol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with metaraminol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with cetirizine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Asenapine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with propoxyphene.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Ciclesonide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Droxicam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with tiapride.", "severity": 2}
{"drug1": "Metixene", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with topiramate.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "trazodone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with proparacaine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Halazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with hydralazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with felbamate.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with NITROUS ACID.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with quetiapine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with atorvastatin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with hydrocortisone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rosuvastatin is combined with atorvastatin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with loratadine.", "severity": 2}
{"drug1": "promazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with cetirizine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Icatibant.", "severity": 2}
{"drug1": "azelastine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with equilin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Empagliflozin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with chlormezanone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "morniflumate", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "metoprolol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with chlorthalidone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Risedronic acid.", "severity": 2}
{"drug1": "midazolam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with tiapride.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Zucapsaicin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with levodopa.", "severity": 2}
{"drug1": "pergolide", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Pazopanib.", "severity": 2}
{"drug1": "flunarizine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with medrysone.", "severity": 2}
{"drug1": "zotepine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with ethosuximide.", "severity": 2}
{"drug1": "loxapine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Nepafenac.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with pirenzepine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with clonidine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with ambenonium.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with clidinium.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PENTAERYTHRITOL TETRANITRATE is combined with Nintedanib.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with flunisolide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Tixocortol.", "severity": 2}
{"drug1": "Limaprost", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with 3,4-Dihydroxybenzaldehyde.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "haloperidol", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with pentazocine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with oxprenolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with resveratrol.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when raloxifene is combined with Ospemifene.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with prazepam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with bromocriptine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Milnacipran.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with etizolam.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Retigabine.", "severity": 2}
{"drug1": "zotepine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with efavirenz.", "severity": 2}
{"drug1": "Normethadone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with loratadine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with quinapril.", "severity": 2}
{"drug1": "pergolide", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Etoricoxib.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with isoxsuprine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with chlorothiazide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with sparfloxacin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with levorphanol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with doxepin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "risperidone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with flunarizine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with zaltoprofen.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "pergolide", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with vinblastine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with trazodone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with prednisone.", "severity": 2}
{"drug1": "suprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "promazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with tiapride.", "severity": 2}
{"drug1": "sulpiride", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with amoxapine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Bretylium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with nortriptyline.", "severity": 2}
{"drug1": "sulindac", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with ketoprofen.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with BISOPROLOL.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with rosiglitazone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Lormetazepam.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with tubocurarine.", "severity": 2}
{"drug1": "codeine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Tolcapone.", "severity": 2}
{"drug1": "codeine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with amitriptyline.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with nifedipine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with baclofen.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with felbamate.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with amitriptyline.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with azelastine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Tolcapone.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Perospirone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Nitroprusside.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with clonidine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with lisinopril.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with apraclonidine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with flumethasone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Estrone sulfate.", "severity": 2}
{"drug1": "selegiline", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Salbutamol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Echothiophate is combined with Carbamylcholine.", "severity": 2}
{"drug1": "midazolam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with nortriptyline.", "severity": 2}
{"drug1": "temazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with nadolol.", "severity": 2}
{"drug1": "tinidazole", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tinidazole is combined with ethanol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with fexofenadine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with bumetanide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "triazolam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with ethotoin.", "severity": 2}
{"drug1": "triazolam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with tranylcypromine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with chlorothiazide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with quinapril.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Propoxycaine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Lormetazepam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Pramocaine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with citalopram.", "severity": 2}
{"drug1": "codeine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Normethadone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with pimozide.", "severity": 2}
{"drug1": "clozapine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with reserpine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with memantine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "biperiden", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with butorphanol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Lapatinib.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with ambenonium.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Riociguat.", "severity": 2}
{"drug1": "alprostadil", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprostadil is combined with salicylic acid.", "severity": 2}
{"drug1": "codeine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with biperiden.", "severity": 2}
{"drug1": "methysergide", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Salbutamol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Deferasirox.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with ethosuximide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Fluprednidene.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Paliperidone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with AMILORIDE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with butamben.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Tramadol", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with meprobamate.", "severity": 2}
{"drug1": "quinapril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Escitalopram.", "severity": 2}
{"drug1": "GLYCEROL PHENYLBUTYRATE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GLYCEROL PHENYLBUTYRATE is combined with atorvastatin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Aceprometazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with tizanidine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with trimipramine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with budesonide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with procaine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with tolfenamic acid.", "severity": 2}
{"drug1": "ropinirole", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with lisinopril.", "severity": 2}
{"drug1": "betamethasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with tubocurarine.", "severity": 2}
{"drug1": "butenafine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with barnidipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Temsirolimus.", "severity": 2}
{"drug1": "lidocaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with tiapride.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with eperisone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Agomelatine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with dipyridamole.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with rescinnamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with felbamate.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with estazolam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with butamben.", "severity": 2}
{"drug1": "flurazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with dantrolene.", "severity": 2}
{"drug1": "loxapine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with moclobemide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with lidocaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with trifluoperazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with cetirizine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with clomipramine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with protriptyline.", "severity": 2}
{"drug1": "gabapentin", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with ondansetron.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with Tapentadol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with oxybutynin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with dibucaine.", "severity": 2}
{"drug1": "ramipril", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with triamterene.", "severity": 2}
{"drug1": "dyclonine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with cetirizine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with fluoxetine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Retigabine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with protriptyline.", "severity": 2}
{"drug1": "reserpine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with isoflurane.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with benzyl alcohol.", "severity": 2}
{"drug1": "reserpine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with prilocaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ethotoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with duloxetine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with zonisamide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Tasimelteon.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with AMILORIDE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with valsartan.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with prilocaine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with meperidine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with ethotoin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with ramipril.", "severity": 2}
{"drug1": "apomorphine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with rasagiline.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Pipamperone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with cetirizine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with alclofenac.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with dipyridamole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with diflorasone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Etomidate.", "severity": 2}
{"drug1": "alclofenac", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with formestane.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with apraclonidine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Remoxipride.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Rotigotine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with malathion.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with tretinoin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with isoflurane.", "severity": 2}
{"drug1": "halothane", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with carisoprodol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Tolcapone.", "severity": 2}
{"drug1": "halothane", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nimodipine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with sparfloxacin.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "etodolac", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Clobetasone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with procarbazine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Apixaban.", "severity": 2}
{"drug1": "methysergide", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Levetiracetam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with secobarbital.", "severity": 2}
{"drug1": "estazolam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with glutethimide.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with vigabatrin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Clodronic Acid.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Desloratadine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with mepivacaine.", "severity": 2}
{"drug1": "prazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with efavirenz.", "severity": 2}
{"drug1": "triazolam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with zotepine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Arformoterol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Metipranolol.", "severity": 2}
{"drug1": "metaraminol", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with nylidrin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with lithium ion.", "severity": 2}
{"drug1": "benazepril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Bretylium.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with floctafenine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with zaleplon.", "severity": 2}
{"drug1": "oxazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "doxepin", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with OLODATEROL.", "severity": 2}
{"drug1": "azelastine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with cilazapril.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with fexofenadine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with gabapentin.", "severity": 2}
{"drug1": "estrone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with cinoxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with prednisone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with citalopram.", "severity": 2}
{"drug1": "clorazepate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with amoxapine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with nortriptyline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "glimepiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with glimepiride.", "severity": 2}
{"drug1": "oxazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "enflurane", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with thiopental.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Quinine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Quinine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with bepridil.", "severity": 2}
{"drug1": "enflurane", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with ethosuximide.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with etizolam.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with chlorpheniramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nifedipine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with mequitazine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "quinapril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with bumetanide.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with chloroquine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Estrone sulfate.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with sulindac.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with triflupromazine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with sotalol.", "severity": 2}
{"drug1": "baclofen", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with clonazepam.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with celecoxib.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with zotepine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with MELPERONE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Flibanserin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with NITROUS ACID.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with pentazocine.", "severity": 2}
{"drug1": "halothane", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with chloral hydrate.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Cis-mdp.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with niflumic acid.", "severity": 2}
{"drug1": "tolmetin", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ramipril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Ramelteon.", "severity": 2}
{"drug1": "morphine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with triflupromazine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with thioridazine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with losartan.", "severity": 2}
{"drug1": "Darunavir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Darunavir is combined with oxycodone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with fludrocortisone.", "severity": 2}
{"drug1": "linezolid", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with loxapine.", "severity": 2}
{"drug1": "linezolid", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Remoxipride.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Ketobemidone.", "severity": 2}
{"drug1": "cefotetan", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cefotetan is combined with Carbocisteine.", "severity": 2}
{"drug1": "codeine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with spironolactone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with tizanidine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with flurazepam.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with methocarbamol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with spironolactone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Fospropofol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with tamoxifen.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Asenapine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with thioridazine.", "severity": 2}
{"drug1": "butenafine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Efonidipine.", "severity": 2}
{"drug1": "topiramate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with protriptyline.", "severity": 2}
{"drug1": "topiramate", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with cetirizine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with enalapril.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with betamethasone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Tolvaptan.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Lorcaserin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with zopiclone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with amisulpride.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with fluocinonide.", "severity": 2}
{"drug1": "scopolamine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with tiagabine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Normethadone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with budesonide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with butamben.", "severity": 2}
{"drug1": "codeine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with methocarbamol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with topiramate.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with efavirenz.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitaxsentan is combined with atorvastatin.", "severity": 2}
{"drug1": "benazepril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with mefenamic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with haloperidol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with tolmetin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Tolcapone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with trandolapril.", "severity": 2}
{"drug1": "zopiclone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with imipramine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Droxicam.", "severity": 2}
{"drug1": "risperidone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with clonidine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Loxoprofen.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with oxaprozin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with loratadine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorouracil is combined with leflunomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with tamoxifen.", "severity": 2}
{"drug1": "trazodone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Perospirone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with primidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "etizolam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with zotepine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Desloratadine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with estazolam.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Risedronic acid.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Difenoxin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with chlorzoxazone.", "severity": 2}
{"drug1": "methadone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "methadone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with chlorthalidone.", "severity": 2}
{"drug1": "ramipril", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nicardipine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with nitrazepam.", "severity": 2}
{"drug1": "reserpine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with terazosin.", "severity": 2}
{"drug1": "reserpine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with butamben.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Ropivacaine.", "severity": 2}
{"drug1": "tirofiban", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with morphine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Deferasirox.", "severity": 2}
{"drug1": "olanzapine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with DESFLURANE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with ethosuximide.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with tiagabine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with cocaine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with ondansetron.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with zonisamide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "levodopa", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with procarbazine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Pizotifen.", "severity": 2}
{"drug1": "reserpine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Olopatadine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Retigabine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Sacubitril.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with ethosuximide.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with citalopram.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Mometasone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with oxycodone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with buspirone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Pomalidomide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with procaine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Olopatadine.", "severity": 2}
{"drug1": "methadone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with zopiclone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with brimonidine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Nabilone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with alclofenac.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with sotalol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with fenbufen.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with butamben.", "severity": 2}
{"drug1": "imipramine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with clonazepam.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with metoprolol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Naftifine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with formestane.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Phenelzine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with lisinopril.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with ropinirole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with dobutamine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with trimipramine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with loratadine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nitrendipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "CAPECITABINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with CAPECITABINE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with procaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Efonidipine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with imipramine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "ACENOCOUMAROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "methysergide", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with histamine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Articaine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamethoxazole is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with doxepin.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with nalbuphine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Iloperidone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with propoxyphene.", "severity": 2}
{"drug1": "biperiden", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with NITROUS ACID.", "severity": 2}
{"drug1": "L-tryptophan", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when L-tryptophan is combined with pargyline.", "severity": 2}
{"drug1": "methadone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Propoxycaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Aripiprazole.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with dobutamine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with zotepine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with MELPERONE.", "severity": 2}
{"drug1": "methysergide", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with alprazolam.", "severity": 2}
{"drug1": "methysergide", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nisoldipine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with MOLINDONE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with prazepam.", "severity": 2}
{"drug1": "THYMOL", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with PERHEXILINE.", "severity": 2}
{"drug1": "aspirin", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Ciclesonide.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Flibanserin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with Gatifloxacin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with cetirizine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with homoharringtonine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with clonidine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with protriptyline.", "severity": 2}
{"drug1": "etoposide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etoposide is combined with clozapine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with PROCATEROL.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Mirabegron.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Metixene.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with antipyrine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with bromocriptine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with clidinium.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with fluocinonide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with scopolamine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "prazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with levodopa.", "severity": 2}
{"drug1": "midazolam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with clomipramine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with betamethasone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Tolcapone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Tasimelteon.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Nitroprusside.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Tixocortol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Eprosartan.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with orphenadrine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with oxymorphone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Pentolinium.", "severity": 2}
{"drug1": "duloxetine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with pimozide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with zotepine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Fluprednidene.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with theobromine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Etidocaine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "clozapine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nitrous oxide.", "severity": 2}
{"drug1": "labetalol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with mecamylamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with carisoprodol.", "severity": 2}
{"drug1": "butalbital", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with clomipramine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with sulpiride.", "severity": 2}
{"drug1": "lorazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with clonazepam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with arsenic trioxide.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with oxycodone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Levocetirizine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with decamethonium.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with amisulpride.", "severity": 2}
{"drug1": "Isometheptene", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isometheptene is combined with prilocaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with pargyline.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with thiothixene.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with NAPROXEN.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Pipotiazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "hexetidine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "nicardipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with spironolactone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "etizolam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with METAXALONE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "losartan", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Dothiepin.", "severity": 2}
{"drug1": "methysergide", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clofazimine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Milnacipran.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with flumethasone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with suprofen.", "severity": 2}
{"drug1": "cocaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with zonisamide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with oxprenolol.", "severity": 2}
{"drug1": "prazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "prazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with amoxapine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with isocarboxazid.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Thioproperazine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with SUFENTANIL.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Pipotiazine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with sulfasalazine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Pomalidomide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with quinidine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Fencamfamin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with DESONIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with lidocaine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with papaverine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with nifedipine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with carisoprodol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with bumetanide.", "severity": 2}
{"drug1": "scopolamine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with zonisamide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with quinapril.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with chlorothiazide.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Clodronic Acid.", "severity": 2}
{"drug1": "triamterene", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with propranolol.", "severity": 2}
{"drug1": "triamterene", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with clonidine.", "severity": 2}
{"drug1": "metolazone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with clonidine.", "severity": 2}
{"drug1": "metolazone", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with propranolol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with efavirenz.", "severity": 2}
{"drug1": "risperidone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Lurasidone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with diflorasone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with carprofen.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with tetracycline.", "severity": 2}
{"drug1": "codeine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Flupentixol.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with ambenonium.", "severity": 2}
{"drug1": "azelastine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with budesonide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with acebutolol.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Levomilnacipran.", "severity": 2}
{"drug1": "buspirone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Difenoxin.", "severity": 2}
{"drug1": "benztropine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Mometasone.", "severity": 2}
{"drug1": "argatroban", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with meperidine.", "severity": 2}
{"drug1": "bepridil", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with D-mannitol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with metolazone.", "severity": 2}
{"drug1": "ethanol", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with bromocriptine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with halothane.", "severity": 2}
{"drug1": "Tramadol", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Isoflurophate.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Perospirone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with galanthamine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with promethazine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with antipyrine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Eletriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Eletriptan.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Agomelatine.", "severity": 2}
{"drug1": "labetalol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with methyldopa.", "severity": 2}
{"drug1": "labetalol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Telmisartan.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Normethadone.", "severity": 2}
{"drug1": "labetalol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with apraclonidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with moclobemide.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with scopolamine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Methadyl acetate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ciprofloxacin.", "severity": 2}
{"drug1": "triamterene", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with nimodipine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Cyamemazine.", "severity": 2}
{"drug1": "valsartan", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with propranolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with VERAPAMIL.", "severity": 2}
{"drug1": "valsartan", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with clonidine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with furosemide.", "severity": 2}
{"drug1": "propofol", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with carvedilol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with oxymorphone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with trimipramine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "clozapine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with prilocaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "CYPROTERONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with bumetanide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Difenoxin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with MELPERONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with enoxacin.", "severity": 2}
{"drug1": "Benidipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Levetiracetam.", "severity": 2}
{"drug1": "procarbazine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Ciclesonide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with carbamazepine.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with celiprolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with HEROIN.", "severity": 2}
{"drug1": "timolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Aliskiren.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Thioproperazine is combined with olanzapine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "medrysone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Ticagrelor.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Triflusal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Triflusal.", "severity": 2}
{"drug1": "Nabilone", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with losartan.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "valsartan", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with meclofenamic acid.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Nabilone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with pargyline.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with sotalol.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Tapentadol.", "severity": 2}
{"drug1": "clemastine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Tasimelteon.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with periciazine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with chlorprothixene.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Aripiprazole.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with hydromorphone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Ditazole.", "severity": 2}
{"drug1": "propofol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with bumetanide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with metoclopramide.", "severity": 2}
{"drug1": "propofol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with quinapril.", "severity": 2}
{"drug1": "diflunisal", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with epirizole.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with desipramine.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with atorvastatin.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Desloratadine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with flunarizine.", "severity": 2}
{"drug1": "carboprost trometamol", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboprost trometamol is combined with Carbetocin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Remoxipride.", "severity": 2}
{"drug1": "oxycodone", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with trichlormethiazide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Cyamemazine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Etidocaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with nisoldipine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with flurandrenolide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with trazodone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with quetiapine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with chlorthalidone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "clomipramine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with celiprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with zonisamide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with tiagabine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Amrinone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Remoxipride.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Teriflunomide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with dyclonine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "adenosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with adenosine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "Imatinib", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Imatinib is combined with sulpiride.", "severity": 2}
{"drug1": "naratriptan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with clomipramine.", "severity": 2}
{"drug1": "primidone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Mephobarbital.", "severity": 2}
{"drug1": "trimipramine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with meclizine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with budesonide.", "severity": 2}
{"drug1": "topiramate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with levodopa.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Tasimelteon.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Pentolinium.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with methocarbamol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with primidone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with spironolactone.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with decamethonium.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with triprolidine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Tolcapone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with chlorothiazide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Flibanserin.", "severity": 2}
{"drug1": "enflurane", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with tetracaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Cyamemazine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with felbamate.", "severity": 2}
{"drug1": "temazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Articaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with NAPROXEN.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Milnacipran.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Frovatriptan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with mefenamic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with equilin.", "severity": 2}
{"drug1": "valsartan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with reserpine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Aceprometazine.", "severity": 2}
{"drug1": "loxapine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with DEZOCINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Fospropofol.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with MOLINDONE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with butalbital.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with venlafaxine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Aceclofenac.", "severity": 2}
{"drug1": "trazodone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with chlorprothixene.", "severity": 2}
{"drug1": "sulindac", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with medrysone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with SERATRODAST.", "severity": 2}
{"drug1": "diltiazem", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with sotalol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with meperidine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with chlorpheniramine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with terazosin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with phenmetrazine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with medrysone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with alclofenac.", "severity": 2}
{"drug1": "pentazocine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with triprolidine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with methocarbamol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with spironolactone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Deferasirox.", "severity": 2}
{"drug1": "pergolide", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with glyburide.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with clemastine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with lidocaine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with flurandrenolide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with apraclonidine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with dobutamine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with fludiazepam.", "severity": 2}
{"drug1": "floctafenine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with halcinonide.", "severity": 2}
{"drug1": "ketamine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with ethosuximide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with difluprednate.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Iloperidone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Tixocortol.", "severity": 2}
{"drug1": "ketamine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with thiopental.", "severity": 2}
{"drug1": "glutethimide", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with meclizine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with procarbazine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with desipramine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Riociguat.", "severity": 2}
{"drug1": "butalbital", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with ethosuximide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with formestane.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Escitalopram.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with moclobemide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "amisulpride", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with fexofenadine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Flupentixol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with azelastine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Melatonin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Etoricoxib.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Etidocaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Eprosartan.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with efavirenz.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Iloperidone.", "severity": 2}
{"drug1": "promazine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with pimozide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with clidinium.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with tranylcypromine.", "severity": 2}
{"drug1": "doxepin", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with isoetharine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with felbamate.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with ethotoin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Ketobemidone.", "severity": 2}
{"drug1": "temazepam", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with flurazepam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with aspirin.", "severity": 2}
{"drug1": "minoxidil", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with captopril.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Pizotifen.", "severity": 2}
{"drug1": "risperidone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with meperidine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with etodolac.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with SERATRODAST.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Aceclofenac.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with zaltoprofen.", "severity": 2}
{"drug1": "bifonazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with cinnarizine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Cariprazine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with betamethasone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with hydralazine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with flurandrenolide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Levocetirizine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with chlorzoxazone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Olsalazine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Etidocaine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Cis-mdp.", "severity": 2}
{"drug1": "methadone", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with PAMABROM.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with Demecarium.", "severity": 2}
{"drug1": "pentamidine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with eperisone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with flunarizine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Fospropofol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Fluspirilene.", "severity": 2}
{"drug1": "amobarbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "methadone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Hexobarbital.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with fluvastatin.", "severity": 2}
{"drug1": "methadone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with lithium ion.", "severity": 2}
{"drug1": "methadone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with amobarbital.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "PHENPROCOUMON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Bretylium", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with hydralazine.", "severity": 2}
{"drug1": "Ecabet", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ecabet is combined with Temsirolimus.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with loxapine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Remoxipride.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Lorcaserin.", "severity": 2}
{"drug1": "selegiline", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with quetiapine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with rasagiline.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "quinapril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Ketobemidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with isoxsuprine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with dibucaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with amoxapine.", "severity": 2}
{"drug1": "triazolam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with nortriptyline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with HEROIN.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with hydralazine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with nortriptyline.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with amoxapine.", "severity": 2}
{"drug1": "diazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with ethotoin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Propoxycaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with prilocaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Pramocaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "propofol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with scopolamine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with estrone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Clodronic Acid.", "severity": 2}
{"drug1": "ramipril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ketorolac.", "severity": 2}
{"drug1": "propofol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with D-mannitol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Isoflurophate.", "severity": 2}
{"drug1": "Apixaban", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apixaban is combined with cyclophosphamide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with flunarizine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with celiprolol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with zotepine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Tixocortol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with chlormezanone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with homoharringtonine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with sertraline.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with amitriptyline.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "nilutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with nilutamide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Tolcapone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with cilazapril.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with hydrocortisone.", "severity": 2}
{"drug1": "Butethal", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with zotepine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Retigabine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with rosiglitazone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with quinapril.", "severity": 2}
{"drug1": "ropinirole", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with chlorothiazide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with efavirenz.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "desipramine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with celiprolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with benazepril.", "severity": 2}
{"drug1": "manidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when manidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "reserpine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nortriptyline.", "severity": 2}
{"drug1": "estazolam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with brotizolam.", "severity": 2}
{"drug1": "metaraminol", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with oxymetazoline.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Echothiophate.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Fospropofol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with norfloxacin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with pimozide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with felodipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with raloxifene.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Fospropofol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Salbutamol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Salsalate", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with moclobemide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with carbamazepine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with butalbital.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with loteprednol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with chlormezanone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with decamethonium.", "severity": 2}
{"drug1": "tretinoin", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with propranolol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Mometasone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Sacubitril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with brotizolam.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Levalbuterol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with terazosin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with fludrocortisone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with procarbazine.", "severity": 2}
{"drug1": "methadone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with zonisamide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with nalidixic acid.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with malathion.", "severity": 2}
{"drug1": "barnidipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with papaverine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with leflunomide.", "severity": 2}
{"drug1": "piracetam", "drug2": "L-thyroxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when piracetam is combined with L-thyroxine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with doxepin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with meclofenamic acid.", "severity": 2}
{"drug1": "pentazocine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with levorphanol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Olopatadine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with perphenazine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with primidone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with vigabatrin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Clodronic Acid.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with levodopa.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with prednisone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with dyclonine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with tranylcypromine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with propoxyphene.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Pazopanib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Paliperidone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with amoxapine.", "severity": 2}
{"drug1": "linezolid", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with amisulpride.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with moclobemide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with oxaprozin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with triflupromazine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with paramethasone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with topiramate.", "severity": 2}
{"drug1": "biperiden", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with oxybutynin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with fexofenadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with buspirone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with ethosuximide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with methylprednisolone.", "severity": 2}
{"drug1": "isradipine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with lisinopril.", "severity": 2}
{"drug1": "alprazolam", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with oxycodone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with acemetacin.", "severity": 2}
{"drug1": "metolazone", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with isoxsuprine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "halothane", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with loratadine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nicardipine.", "severity": 2}
{"drug1": "halothane", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with prazosin.", "severity": 2}
{"drug1": "clozapine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with tizanidine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with proparacaine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "benzthiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with benzthiazide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Halazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with flurazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Pipamperone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with indapamide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with NITROUS ACID.", "severity": 2}
{"drug1": "methyldopa", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with quetiapine.", "severity": 2}
{"drug1": "argatroban", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with aspirin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Retigabine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with fexofenadine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with carisoprodol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with betaxolol.", "severity": 2}
{"drug1": "dienestrol", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dienestrol is combined with Ospemifene.", "severity": 2}
{"drug1": "estrone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with ambenonium.", "severity": 2}
{"drug1": "ibudilast", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with mesalamine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with flurandrenolide.", "severity": 2}
{"drug1": "teniposide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when teniposide is combined with leflunomide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with budesonide.", "severity": 2}
{"drug1": "trazodone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Difenoxin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Pomalidomide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with quetiapine.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with fluoxetine.", "severity": 2}
{"drug1": "estrone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with physostigmine.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with duloxetine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiotepa is combined with leflunomide.", "severity": 2}
{"drug1": "valsartan", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with enalapril.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with methylphenidate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with gabapentin.", "severity": 2}
{"drug1": "reserpine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with tiapride.", "severity": 2}
{"drug1": "lorazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with resveratrol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with metoclopramide.", "severity": 2}
{"drug1": "atenolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Pramocaine.", "severity": 2}
{"drug1": "enalapril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with alclofenac.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Lacidipine.", "severity": 2}
{"drug1": "sulindac", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with carprofen.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with oxaprozin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with tiapride.", "severity": 2}
{"drug1": "hexetidine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with felodipine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with trimipramine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with isoxsuprine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with procaine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with meclizine.", "severity": 2}
{"drug1": "timolol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with nadolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with paroxetine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with ADAPALENE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Mephobarbital.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with bumetanide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with thalidomide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Lurasidone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with phenytoin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with carbamazepine.", "severity": 2}
{"drug1": "methadone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Etomidate.", "severity": 2}
{"drug1": "carprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "cabergoline", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with risperidone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "carprofen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Loxoprofen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with equilin.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with pentazocine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "carprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Droxicam.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with anastrozole.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Ropivacaine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with butamben.", "severity": 2}
{"drug1": "cetirizine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with primidone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with spironolactone.", "severity": 2}
{"drug1": "zonisamide", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with fexofenadine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Spectinomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Spectinomycin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with etizolam.", "severity": 2}
{"drug1": "Asenapine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with loratadine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Pipamperone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Aripiprazole.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with trandolapril.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with chlorprothixene.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Bretylium.", "severity": 2}
{"drug1": "naloxone", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naloxone is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with metoclopramide.", "severity": 2}
{"drug1": "triamterene", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with indapamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with linezolid.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Propacetamol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "metolazone", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with lisinopril.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Loxoprofen.", "severity": 2}
{"drug1": "estazolam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Etidocaine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with lithium ion.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Butethal.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with isoxsuprine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with nicotinamide.", "severity": 2}
{"drug1": "metolazone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with nitroglycerin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "anagrelide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with anagrelide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "carmustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with carmustine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with flunisolide.", "severity": 2}
{"drug1": "triprolidine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with scopolamine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "olanzapine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with methoxyflurane.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Eplerenone.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with nisoldipine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with HEROIN.", "severity": 2}
{"drug1": "trazodone", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with fluvoxamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Etidocaine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with trimipramine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Riociguat.", "severity": 2}
{"drug1": "butorphanol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with DEZOCINE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Pentolinium.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Difenoxin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with trimipramine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Propoxycaine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Pipamperone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Pramocaine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with resveratrol.", "severity": 2}
{"drug1": "reserpine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with maprotiline.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with gabapentin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with gabapentin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Fluprednidene.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with procarbazine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Oxetacaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Erismodegib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Erismodegib.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with losartan.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with sulindac.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with chloroquine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Propiverine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with PROCATEROL.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with rasagiline.", "severity": 2}
{"drug1": "procarbazine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with tubocurarine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with bupivacaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Eplerenone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Isometheptene.", "severity": 2}
{"drug1": "tolazamide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazamide is combined with ethanol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with papaverine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with testosterone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with efavirenz.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with nicardipine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with pravastatin.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Flibanserin.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Pizotifen.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Metipranolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with celecoxib.", "severity": 2}
{"drug1": "ramipril", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with indapamide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with thioridazine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with losartan.", "severity": 2}
{"drug1": "cocaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with tiapride.", "severity": 2}
{"drug1": "dobutamine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Melatonin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with methscopolamine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with clonazepam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with promethazine.", "severity": 2}
{"drug1": "dobutamine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with isoproterenol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with sotalol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Tadalafil.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Normethadone.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with pravastatin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with propoxyphene.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Atracurium besylate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with dyclonine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with diazepam.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with bepridil.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with trandolapril.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with thioridazine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with oxybutynin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Aceprometazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with nitrazepam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with MOLINDONE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Fospropofol.", "severity": 2}
{"drug1": "indapamide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with chlorothiazide.", "severity": 2}
{"drug1": "sulindac", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with zaltoprofen.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with olanzapine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with scopolamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with brotizolam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with oxybutynin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tolazoline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "trazodone", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with duloxetine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with timolol.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with dantrolene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Levetiracetam.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with meclizine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with triamterene.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with Calcipotriol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Mephobarbital.", "severity": 2}
{"drug1": "butalbital", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with amitriptyline.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with nalbuphine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with oxprenolol.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Riociguat.", "severity": 2}
{"drug1": "nabumetone", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with meclofenamic acid.", "severity": 2}
{"drug1": "sulindac", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Clodronic Acid.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with mecamylamine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with ketamine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with morphine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with quetiapine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Levetiracetam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Fencamfamin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Milnacipran.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Gemifloxacin.", "severity": 2}
{"drug1": "ketamine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with dantrolene.", "severity": 2}
{"drug1": "prilocaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with amoxapine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with nortriptyline.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with diclofenac.", "severity": 2}
{"drug1": "lisinopril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with AMILORIDE.", "severity": 2}
{"drug1": "losartan", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Olopatadine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with PROCATEROL.", "severity": 2}
{"drug1": "clomipramine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with rasagiline.", "severity": 2}
{"drug1": "nimesulide", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with halcinonide.", "severity": 2}
{"drug1": "midazolam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Aceprometazine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with difluprednate.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with sertraline.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with phenytoin.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with azelastine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Cis-mdp.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Etoricoxib.", "severity": 2}
{"drug1": "zaleplon", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with DESFLURANE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with methylprednisolone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nimodipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "sotalol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with hydralazine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Varenicline.", "severity": 2}
{"drug1": "butenafine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Pinaverium.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Iloperidone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with maprotiline.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with nefazodone.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with citalopram.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with nicardipine.", "severity": 2}
{"drug1": "loxapine", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with promazine.", "severity": 2}
{"drug1": "loxapine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with methocarbamol.", "severity": 2}
{"drug1": "loxapine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with methylphenidate.", "severity": 2}
{"drug1": "loxapine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with triprolidine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with lidocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with DESFLURANE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with diclofenac.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with thalidomide.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with lidocaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with fluvoxamine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with clemastine.", "severity": 2}
{"drug1": "tiapride", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with ethosuximide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Olsalazine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with levorphanol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Articaine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimethoprim is combined with memantine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with topiramate.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with dextromethorphan.", "severity": 2}
{"drug1": "estazolam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with quetiapine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "temazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with clonidine.", "severity": 2}
{"drug1": "metolazone", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with quinapril.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with fluoxetine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with duloxetine.", "severity": 2}
{"drug1": "propofol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Retigabine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Metipranolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Escitalopram.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with memantine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with tranylcypromine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with tizanidine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with prilocaine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpropamide is combined with ethanol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with ethotoin.", "severity": 2}
{"drug1": "promazine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with quazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with citalopram.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with CYCLIZINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with METAXALONE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with hydralazine.", "severity": 2}
{"drug1": "butalbital", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with protriptyline.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "ramipril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with carvedilol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with epirizole.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with indapamide.", "severity": 2}
{"drug1": "propofol", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ethchlorvynol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Mersalyl.", "severity": 2}
{"drug1": "propofol", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ESMOLOL.", "severity": 2}
{"drug1": "propofol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with baclofen.", "severity": 2}
{"drug1": "diazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with fludiazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with chloral hydrate.", "severity": 2}
{"drug1": "formestane", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Gemifloxacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with flumethasone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with meclofenamic acid.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with propranolol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with zopiclone.", "severity": 2}
{"drug1": "procyclidine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with levorphanol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with oxymorphone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with salicylic acid.", "severity": 2}
{"drug1": "nimesulide", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with methylprednisolone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with HEROIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Mometasone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Levocetirizine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with sulpiride.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with doxepin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with nitrendipine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with Escitalopram.", "severity": 2}
{"drug1": "timolol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with indapamide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Asenapine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Halobetasol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Lornoxicam.", "severity": 2}
{"drug1": "propofol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "propofol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with prazepam.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with bupropion.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with propofol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with chlorthalidone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Bretylium.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with acetazolamide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Agomelatine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Levocetirizine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with captopril.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "equilin", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Trovafloxacin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with acebutolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with levorphanol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with reserpine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with D-mannitol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with etizolam.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Pipotiazine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with dantrolene.", "severity": 2}
{"drug1": "minoxidil", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with cilazapril.", "severity": 2}
{"drug1": "meclizine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with zonisamide.", "severity": 2}
{"drug1": "metolazone", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Dapagliflozin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with tiagabine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with flunarizine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with meclizine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with trimipramine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Remoxipride.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with clidinium.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Clevidipine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with efavirenz.", "severity": 2}
{"drug1": "sertraline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Cyamemazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with butalbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Lormetazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with vigabatrin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Romidepsin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Romidepsin.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with perphenazine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with primidone.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with moclobemide.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nelfinavir is combined with toremifene.", "severity": 2}
{"drug1": "dibucaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with primidone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Lurasidone.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nelfinavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Metixene", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with AMILORIDE.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Metipranolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with tetracaine.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Masoprocol.", "severity": 2}
{"drug1": "meperidine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with amoxapine.", "severity": 2}
{"drug1": "dopamine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with isoproterenol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rivaroxaban is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Propiverine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with loratadine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with meperidine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with droperidol.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Pizotifen.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Estrone sulfate.", "severity": 2}
{"drug1": "dibucaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with triprolidine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with indapamide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Olopatadine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with imipramine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with methocarbamol.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with Carbamylcholine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Frovatriptan.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Articaine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Perospirone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with SUFENTANIL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Fencamfamin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with furosemide.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with tizanidine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with fleroxacin.", "severity": 2}
{"drug1": "morphine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Tolcapone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with D-mannitol.", "severity": 2}
{"drug1": "meperidine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Flibanserin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with scopolamine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Naftifine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "butamben", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with clonidine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with nalbuphine.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with Levomilnacipran.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Frovatriptan.", "severity": 2}
{"drug1": "pimozide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with quetiapine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Etomidate.", "severity": 2}
{"drug1": "diltiazem", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with triamterene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with bupivacaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Ropivacaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Butethal.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Naftifine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with felbamate.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Salsalate.", "severity": 2}
{"drug1": "pimozide", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Asenapine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Flibanserin.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydrotachysterol is combined with Calcipotriol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "indapamide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with ouabain.", "severity": 2}
{"drug1": "meprobamate", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with cocaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with triamterene.", "severity": 2}
{"drug1": "benazepril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with oxybutynin.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with terazosin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methadone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with dichlorphenamide.", "severity": 2}
{"drug1": "prazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with tiapride.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with alclofenac.", "severity": 2}
{"drug1": "trimipramine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with PROCATEROL.", "severity": 2}
{"drug1": "trimipramine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with rasagiline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with meclizine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Tasimelteon.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with fosinopril.", "severity": 2}
{"drug1": "Artemether", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Lercanidipine.", "severity": 2}
{"drug1": "codeine", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with clorazepate.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with methscopolamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with trazodone.", "severity": 2}
{"drug1": "budesonide", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with decamethonium.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Flibanserin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with flunitrazepam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "trimipramine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with felbamate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with cocaine.", "severity": 2}
{"drug1": "benazepril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with sulfasalazine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with triflupromazine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with zonisamide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with topiramate.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Pipamperone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Desloratadine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with metolazone.", "severity": 2}
{"drug1": "benazepril", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with CARTEOLOL.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rifaximin is combined with clopidogrel.", "severity": 2}
{"drug1": "butabarbital", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with thiamylal.", "severity": 2}
{"drug1": "promethazine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with doxepin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chlorothiazide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Tramadol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with bumetanide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with trazodone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Etomidate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Normethadone.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with pravastatin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Ropivacaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with bupivacaine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with sulindac.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with salicylamide.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with nifedipine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with risperidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with selegiline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Difenoxin.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with methscopolamine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "flutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with flutamide.", "severity": 2}
{"drug1": "loxapine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "loxapine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with glutethimide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "tobramycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with tobramycin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Ramelteon.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Asenapine.", "severity": 2}
{"drug1": "SULFADOXINE", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SULFADOXINE is combined with dapsone.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with budesonide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Lormetazepam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with efavirenz.", "severity": 2}
{"drug1": "morphine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with mesoridazine.", "severity": 2}
{"drug1": "morphine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with maprotiline.", "severity": 2}
{"drug1": "codeine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with bupivacaine.", "severity": 2}
{"drug1": "codeine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Etomidate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Remoxipride.", "severity": 2}
{"drug1": "methadone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with procaine.", "severity": 2}
{"drug1": "methadone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with trimipramine.", "severity": 2}
{"drug1": "pergolide", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with lomustine.", "severity": 2}
{"drug1": "pergolide", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with mitoxantrone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with salicylamide.", "severity": 2}
{"drug1": "loxapine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with halothane.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Asenapine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Halazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with felbamate.", "severity": 2}
{"drug1": "enflurane", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Pipamperone.", "severity": 2}
{"drug1": "nystatin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with nifedipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with clozapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Fluspirilene.", "severity": 2}
{"drug1": "etizolam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with fexofenadine.", "severity": 2}
{"drug1": "midazolam", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with trifluoperazine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with promazine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "CABAZITAXEL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Aceprometazine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with flunarizine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with enoxacin.", "severity": 2}
{"drug1": "codeine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with D-mannitol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "VERTEPORFIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with VERTEPORFIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with NITROUS ACID.", "severity": 2}
{"drug1": "thiopental", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with fexofenadine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with nifedipine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with nitroglycerin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with lisinopril.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with miconazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with thiopental.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Fencamfamin.", "severity": 2}
{"drug1": "clozapine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with AMILORIDE.", "severity": 2}
{"drug1": "clozapine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ethosuximide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfadimethoxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfadimethoxine.", "severity": 2}
{"drug1": "clozapine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with doxazosin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Cyamemazine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with venlafaxine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with paramethasone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with D-mannitol.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with nicardipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with scopolamine.", "severity": 2}
{"drug1": "triazolam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with methoxyflurane.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Fencamfamin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Mephobarbital.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with rasagiline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with doxepin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Nebivolol.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with nimodipine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Halobetasol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Lopinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Lopinavir.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with mefenamic acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Flibanserin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with tiapride.", "severity": 2}
{"drug1": "clozapine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with efavirenz.", "severity": 2}
{"drug1": "midazolam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with tiagabine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with betamethasone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Lorcaserin.", "severity": 2}
{"drug1": "selegiline", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with bezafibrate.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with felodipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with acetazolamide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with diltiazem.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with estrone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Benidipine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with manidipine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with mefloquine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with enflurane.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "zidovudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with zidovudine.", "severity": 2}
{"drug1": "Nedaplatin", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nedaplatin is combined with topotecan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lopinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rifampicin is combined with Lopinavir.", "severity": 2}
{"drug1": "buspirone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with DEZOCINE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with tolazoline.", "severity": 2}
{"drug1": "pimozide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Tasimelteon.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with spironolactone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Remoxipride.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "atenolol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with felbamate.", "severity": 2}
{"drug1": "amifostine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Propoxycaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with venlafaxine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with chlorpheniramine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with clemastine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with lidocaine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with doxepin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with mesoridazine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Regorafenib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with fluoxetine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with triamcinolone.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with duloxetine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Milnacipran.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Mirabegron.", "severity": 2}
{"drug1": "Spirapril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with antipyrine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with spironolactone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with methocarbamol.", "severity": 2}
{"drug1": "reserpine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with triprolidine.", "severity": 2}
{"drug1": "biperiden", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with topiramate.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Difenoxin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with felbamate.", "severity": 2}
{"drug1": "zopiclone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Empagliflozin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with furosemide.", "severity": 2}
{"drug1": "benztropine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Tramadol.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with salicylic acid.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Lercanidipine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Perospirone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Caspofungin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with zonisamide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Lurasidone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with rasagiline.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Retigabine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with ondansetron.", "severity": 2}
{"drug1": "Avanafil", "drug2": "alprostadil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Avanafil is combined with alprostadil.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with carisoprodol.", "severity": 2}
{"drug1": "reserpine", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with phenobarbital.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Pomalidomide.", "severity": 2}
{"drug1": "Vinflunine", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vinflunine is combined with mitomycin C.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Varenicline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with pilocarpine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with oxymorphone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with enalapril.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with gabapentin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with fluvastatin.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with butalbital.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with pramipexole.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with galanthamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with propoxyphene.", "severity": 2}
{"drug1": "pentazocine", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with trichlormethiazide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with dyclonine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "enflurane", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with MOLINDONE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with tretinoin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with losartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with isoflurane.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "enflurane", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with lidocaine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with alclofenac.", "severity": 2}
{"drug1": "enflurane", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with clemastine.", "severity": 2}
{"drug1": "enflurane", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with venlafaxine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Amrinone.", "severity": 2}
{"drug1": "suprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with glutethimide.", "severity": 2}
{"drug1": "amifostine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Phenelzine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Methadyl acetate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Lurasidone.", "severity": 2}
{"drug1": "Quinine", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Quinine is combined with mefloquine.", "severity": 2}
{"drug1": "butamben", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with loratadine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Pramocaine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Icatibant.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with bezafibrate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with promethazine.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salbutamol is combined with atorvastatin.", "severity": 2}
{"drug1": "butamben", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with imipramine.", "severity": 2}
{"drug1": "clidinium", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with zonisamide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with brotizolam.", "severity": 2}
{"drug1": "bumetanide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with methyldopa.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Telmisartan.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with Escitalopram.", "severity": 2}
{"drug1": "bumetanide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with apraclonidine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Cabozantinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Cabozantinib.", "severity": 2}
{"drug1": "enflurane", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with tranylcypromine.", "severity": 2}
{"drug1": "enflurane", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with prilocaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with ethotoin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with flunarizine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with meclizine.", "severity": 2}
{"drug1": "IODIPAMIDE", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when IODIPAMIDE is combined with metformin.", "severity": 2}
{"drug1": "morphine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Torasemide.", "severity": 2}
{"drug1": "reserpine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with quinapril.", "severity": 2}
{"drug1": "hexetidine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with xylometazoline.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with fluocinonide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with isoxsuprine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with chlorthalidone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with tranylcypromine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Hexobarbital.", "severity": 2}
{"drug1": "gabapentin", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with lithium ion.", "severity": 2}
{"drug1": "nystatin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Lormetazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Ramelteon.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Butethal.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Eplerenone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with methazolamide.", "severity": 2}
{"drug1": "zotepine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Desloratadine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Aripiprazole.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with nimesulide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Elbasvir.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Olsalazine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Difenoxin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with fenbufen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "polythiazide", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with carbamazepine.", "severity": 2}
{"drug1": "imipramine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with sumatriptan.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Fospropofol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ADAPALENE.", "severity": 2}
{"drug1": "suprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nitrendipine.", "severity": 2}
{"drug1": "carboplatin", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboplatin is combined with topotecan.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Riociguat.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with halothane.", "severity": 2}
{"drug1": "aspirin", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with scopolamine.", "severity": 2}
{"drug1": "terconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with bepridil.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Difenoxin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Asenapine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with isocarboxazid.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with desipramine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Tolcapone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Naftifine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ibuprofen.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Perospirone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Tasimelteon.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nitrendipine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with tetracaine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "imipramine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with tolazoline.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "prazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with butalbital.", "severity": 2}
{"drug1": "furazolidone", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with clenbuterol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with buprenorphine.", "severity": 2}
{"drug1": "cocaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with methocarbamol.", "severity": 2}
{"drug1": "zotepine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Retigabine.", "severity": 2}
{"drug1": "cocaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with triprolidine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with CLONIXIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with bromazepam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with glutethimide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Frovatriptan.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with bumetanide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with chlorothiazide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with quinapril.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "furosemide", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Eplerenone.", "severity": 2}
{"drug1": "pimozide", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with dibucaine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SAQUINAVIR is combined with Temsirolimus.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Normethadone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with lithium ion.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Risedronic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Estrone sulfate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Apremilast.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Pemetrexed", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Pemetrexed.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with cinoxacin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Risedronic acid.", "severity": 2}
{"drug1": "thalidomide", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with trandolapril.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with ranitidine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with clemastine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with clonazepam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with OLODATEROL.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Etomidate.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Rotigotine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with tetracaine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with papaverine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluprednidene.", "severity": 2}
{"drug1": "enalapril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with acebutolol.", "severity": 2}
{"drug1": "amifostine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with propofol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with cilnidipine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with tolazoline.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Pipotiazine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Isometheptene.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with ibuprofen.", "severity": 2}
{"drug1": "loratadine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with tiagabine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with tranylcypromine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with meclizine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with risperidone.", "severity": 2}
{"drug1": "zonisamide", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with dantrolene.", "severity": 2}
{"drug1": "rasagiline", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with droxidopa.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with zafirlukast.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Butethal.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Nepafenac.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with manidipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with methoxyflurane.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with HEROIN.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Articaine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with Varenicline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Pomalidomide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Ketobemidone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with desipramine.", "severity": 2}
{"drug1": "atenolol", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with trandolapril.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with zolmitriptan.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with nicardipine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with tizanidine.", "severity": 2}
{"drug1": "imipramine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with papaverine.", "severity": 2}
{"drug1": "imipramine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nifedipine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with isoproterenol.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with etizolam.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with methazolamide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Ketobemidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with MELPERONE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with metoclopramide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with oxymorphone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nimesulide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with diflorasone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nilvadipine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Butethal.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with metoclopramide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "bromazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with lithium ion.", "severity": 2}
{"drug1": "amisulpride", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with nitrous oxide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with carvedilol.", "severity": 2}
{"drug1": "Trospium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with codeine.", "severity": 2}
{"drug1": "methenamine", "drug2": "sulfisoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methenamine is combined with sulfisoxazole.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Metipranolol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with vigabatrin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with vigabatrin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with lithium ion.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Hexobarbital.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Butethal.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with amobarbital.", "severity": 2}
{"drug1": "bepridil", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with acebutolol.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Salmeterol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with flunarizine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Fluspirilene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with penbutolol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with meperidine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with propoxyphene.", "severity": 2}
{"drug1": "5-azacytidine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-azacytidine is combined with leflunomide.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with Pomalidomide.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with penbutolol.", "severity": 2}
{"drug1": "levodopa", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Retigabine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Asenapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with thioridazine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with triamcinolone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Tixocortol.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with venlafaxine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with loteprednol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Pomalidomide.", "severity": 2}
{"drug1": "butalbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with triprolidine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with methadone.", "severity": 2}
{"drug1": "methysergide", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with acetaminophen.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with bumetanide.", "severity": 2}
{"drug1": "Metixene", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with methscopolamine.", "severity": 2}
{"drug1": "clonidine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with hydralazine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with quinapril.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with bumetanide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with topiramate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with triamterene.", "severity": 2}
{"drug1": "prilocaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with METAXALONE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with tretinoin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ethotoin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with zaltoprofen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with prilocaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with tranylcypromine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with bromazepam.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Desloratadine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Lercanidipine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with prazosin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with fosinopril.", "severity": 2}
{"drug1": "lisinopril", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with captopril.", "severity": 2}
{"drug1": "Droxicam", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with estrone.", "severity": 2}
{"drug1": "azelastine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Escitalopram.", "severity": 2}
{"drug1": "prednisone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with norfloxacin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with clozapine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with clidinium.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with lidocaine.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloramphenicol is combined with atorvastatin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Nebivolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with nimodipine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with nefazodone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "doxylamine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with citalopram.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with cilazapril.", "severity": 2}
{"drug1": "betaxolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Metipranolol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with lisinopril.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with ethotoin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with irbesartan.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with nitroglycerin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with trimipramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ethotoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Retigabine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with prilocaine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with zonisamide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with tranylcypromine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with papaverine.", "severity": 2}
{"drug1": "halothane", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with chlormezanone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with tiagabine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with zotepine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with diazoxide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with chloral hydrate.", "severity": 2}
{"drug1": "HEROIN", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "loxapine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Tolcapone.", "severity": 2}
{"drug1": "loxapine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with amitriptyline.", "severity": 2}
{"drug1": "aspirin", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Zoledronic acid.", "severity": 2}
{"drug1": "aspirin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with METAXALONE.", "severity": 2}
{"drug1": "enflurane", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with mepivacaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Nepafenac.", "severity": 2}
{"drug1": "amiodarone", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with fenoldopam.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Lorcaserin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with selegiline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with buspirone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Eprosartan.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with paroxetine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Conivaptan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with clemastine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with lidocaine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with ethotoin.", "severity": 2}
{"drug1": "sulindac", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with azelastine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with prilocaine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with homoharringtonine.", "severity": 2}
{"drug1": "morphine", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Drospirenone.", "severity": 2}
{"drug1": "glutethimide", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with cetirizine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with protriptyline.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with tretinoin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with GUANFACINE.", "severity": 2}
{"drug1": "halothane", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with zonisamide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Aliskiren.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Pipamperone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with zonisamide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tramadol", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with diazepam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with cocaine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with tiagabine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Retigabine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with baclofen.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Droxicam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Milnacipran.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nifedipine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with tolmetin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with papaverine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Normethadone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with tubocurarine.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with dobutamine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nitrendipine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with ketoprofen.", "severity": 2}
{"drug1": "Normethadone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with doxepin.", "severity": 2}
{"drug1": "triazolam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with quetiapine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with ketamine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Halobetasol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Methadyl acetate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with glutethimide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Propacetamol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with prilocaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with tranylcypromine.", "severity": 2}
{"drug1": "procaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with citalopram.", "severity": 2}
{"drug1": "Etomidate", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with ethotoin.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with terbutaline.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Estrone sulfate.", "severity": 2}
{"drug1": "sulfamethazine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamethazine is combined with mecamylamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "estazolam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with duloxetine.", "severity": 2}
{"drug1": "ketamine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with METAXALONE.", "severity": 2}
{"drug1": "estazolam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with fluoxetine.", "severity": 2}
{"drug1": "allopurinol", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when allopurinol is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pomalidomide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with scopolamine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with donepezil.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with proparacaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with halothane.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Halazepam.", "severity": 2}
{"drug1": "Salsalate", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with betamethasone.", "severity": 2}
{"drug1": "propofol", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with propranolol.", "severity": 2}
{"drug1": "risperidone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with dantrolene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with desipramine.", "severity": 2}
{"drug1": "propofol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with clonidine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with indapamide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Propoxycaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Pramocaine.", "severity": 2}
{"drug1": "metolazone", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with digitoxin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with thiamylal.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Sacubitril.", "severity": 2}
{"drug1": "Butethal", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Perospirone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with halothane.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "metaraminol", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with Ephedrine.", "severity": 2}
{"drug1": "bepridil", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with imipramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nicotinamide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nitrendipine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "quazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with tetracaine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with chlorprothixene.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with suprofen.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with loteprednol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with propoxyphene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with polythiazide.", "severity": 2}
{"drug1": "bepridil", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with prazosin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with promethazine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with diflunisal.", "severity": 2}
{"drug1": "HEROIN", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with PAMABROM.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Pizotifen.", "severity": 2}
{"drug1": "formestane", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Echothiophate.", "severity": 2}
{"drug1": "bromazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with scopolamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Eplerenone.", "severity": 2}
{"drug1": "metolazone", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with irbesartan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with morphine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with thiamylal.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with enoxacin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Oxetacaine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with tolmetin.", "severity": 2}
{"drug1": "formestane", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with norfloxacin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with Olsalazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with cilnidipine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Deferasirox.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Aceclofenac.", "severity": 2}
{"drug1": "antipyrine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with zaltoprofen.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Butethal.", "severity": 2}
{"drug1": "manidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when manidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Fospropofol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "topiramate", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with METAXALONE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Hexobarbital.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with ambenonium.", "severity": 2}
{"drug1": "ipratropium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Halazepam.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with D-mannitol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with proparacaine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with scopolamine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with rasagiline.", "severity": 2}
{"drug1": "labetalol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with hydralazine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with nifedipine.", "severity": 2}
{"drug1": "propofol", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with sulpiride.", "severity": 2}
{"drug1": "labetalol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Varenicline.", "severity": 2}
{"drug1": "propofol", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nimodipine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with mefenamic acid.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Propiverine.", "severity": 2}
{"drug1": "etodolac", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with NAPROXEN.", "severity": 2}
{"drug1": "furosemide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with felbamate.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "propofol", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with thiothixene.", "severity": 2}
{"drug1": "propofol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Pipotiazine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Lornoxicam.", "severity": 2}
{"drug1": "indapamide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with salicylamide.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with METAXALONE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with clonidine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with cilazapril.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nitric oxide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Normethadone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with perphenazine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Zoledronic acid.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Torasemide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "selegiline", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with tiapride.", "severity": 2}
{"drug1": "Torasemide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Perospirone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Flupentixol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with acetylcholine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with budesonide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with fexofenadine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nitrofurantoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with nitrofurantoin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "meperidine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Melatonin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "naratriptan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with perphenazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Perospirone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with hydralazine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with dexamethasone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Levocetirizine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with tranylcypromine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with prilocaine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with methoxyflurane.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with Varenicline.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Pipamperone.", "severity": 2}
{"drug1": "pimozide", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with KETAZOLAM.", "severity": 2}
{"drug1": "topiramate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with vigabatrin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with tiapride.", "severity": 2}
{"drug1": "pimozide", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with quazepam.", "severity": 2}
{"drug1": "pimozide", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with prazepam.", "severity": 2}
{"drug1": "meperidine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Paliperidone.", "severity": 2}
{"drug1": "sotalol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with nitroglycerin.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "sotalol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with lisinopril.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Lormetazepam.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with paroxetine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with selegiline.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with oxycodone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Pizotifen.", "severity": 2}
{"drug1": "atenolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with cilazapril.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Flibanserin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with flunitrazepam.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with meclofenamic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with leflunomide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with fexofenadine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with loratadine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with meperidine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with Tramadol.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Pizotifen.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ketoprofen.", "severity": 2}
{"drug1": "cabergoline", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with promethazine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with tranylcypromine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Pomalidomide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "codeine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with doxepin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dacarbazine is combined with clozapine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with tolmetin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with haloperidol.", "severity": 2}
{"drug1": "quinidine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Naftifine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with diphenhydramine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Amrinone.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with clenbuterol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with spironolactone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with butalbital.", "severity": 2}
{"drug1": "Ditazole", "drug2": "Treprostinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ditazole is combined with Treprostinil.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Deferasirox.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Etidronic acid.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Ciclesonide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with enflurane.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with SUFENTANIL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Pizotifen.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with methocarbamol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with trazodone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with triprolidine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with chlorprothixene.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with etizolam.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Fospropofol.", "severity": 2}
{"drug1": "clidinium", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Pomalidomide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with methscopolamine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Ciclesonide.", "severity": 2}
{"drug1": "clidinium", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Levomilnacipran.", "severity": 2}
{"drug1": "clozapine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with cilazapril.", "severity": 2}
{"drug1": "baclofen", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with efavirenz.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with glutethimide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "valsartan", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with trandolapril.", "severity": 2}
{"drug1": "quazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "quazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with amoxapine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with ropinirole.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with maprotiline.", "severity": 2}
{"drug1": "captopril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with suprofen.", "severity": 2}
{"drug1": "aspirin", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Aceclofenac.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfisoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfisoxazole.", "severity": 2}
{"drug1": "loteprednol", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with physostigmine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "warfarin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with warfarin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Ramelteon.", "severity": 2}
{"drug1": "Limaprost", "drug2": "pentosan polysulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with pentosan polysulfate.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with carisoprodol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with butalbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with polythiazide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with nitroglycerin.", "severity": 2}
{"drug1": "benazepril", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with methazolamide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with lisinopril.", "severity": 2}
{"drug1": "meperidine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with amisulpride.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with CLONIXIN.", "severity": 2}
{"drug1": "indomethacin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with AMILORIDE.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ethosuximide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with doxazosin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with oxaprozin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Clobetasone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with labetalol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with thiopental.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with dantrolene.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Loxoprofen.", "severity": 2}
{"drug1": "dantrolene", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pimozide", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with procaine.", "severity": 2}
{"drug1": "etodolac", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with epirizole.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with CLONIXIN.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with rescinnamine.", "severity": 2}
{"drug1": "methadone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with propoxyphene.", "severity": 2}
{"drug1": "oxycodone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with MELPERONE.", "severity": 2}
{"drug1": "methazolamide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with penbutolol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with METAXALONE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Trilostane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Trilostane.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with ethotoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with prilocaine.", "severity": 2}
{"drug1": "promazine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with levorphanol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "CAPECITABINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with CAPECITABINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with primidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with tolazoline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with paroxetine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with tolfenamic acid.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with metaproterenol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with D-mannitol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with carvedilol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with fludiazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with chloral hydrate.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 3,4-Dihydroxybenzaldehyde is combined with Deferasirox.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Icatibant.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with tenoxicam.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Escitalopram.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "midazolam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with METAXALONE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with nabumetone.", "severity": 2}
{"drug1": "enalapril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with penbutolol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ketorolac.", "severity": 2}
{"drug1": "proparacaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with lithium ion.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "atenolol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with irbesartan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "thiotepa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with thiotepa.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Escitalopram.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with fleroxacin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Flupentixol.", "severity": 2}
{"drug1": "atenolol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with chlorothiazide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with triprolidine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with chlormezanone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with methocarbamol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Fludarabine", "drug2": "pentostatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fludarabine is combined with pentostatin.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Flibanserin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with clomipramine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with quetiapine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with tretinoin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Fluprednidene.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with felbamate.", "severity": 2}
{"drug1": "furosemide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Bretylium.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with benzocaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with barnidipine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Valrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Valrubicin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with dibucaine.", "severity": 2}
{"drug1": "atenolol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with enalapril.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mequitazine is combined with atorvastatin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with GUANFACINE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "pimozide", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Perospirone.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with acemetacin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with zotepine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with MELPERONE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with ethosuximide.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprenolol is combined with nicotine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprenolol is combined with Cevimeline.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Fesoterodine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with GUANFACINE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Tixocortol.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "ribostamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with ribostamycin.", "severity": 2}
{"drug1": "Propiverine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with butorphanol.", "severity": 2}
{"drug1": "promazine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with periciazine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with scopolamine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with rizatriptan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with naratriptan.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Pizotifen.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Milnacipran.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "carprofen", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with oxaprozin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Agomelatine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nisoldipine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Ciclesonide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Lurasidone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with loratadine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with prazosin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Ketobemidone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with amcinonide.", "severity": 2}
{"drug1": "midodrine", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with epinephrine.", "severity": 2}
{"drug1": "enalapril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "budesonide", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with Gatifloxacin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with benzocaine.", "severity": 2}
{"drug1": "budesonide", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with memantine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "morphine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with clonazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with thiopental.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with equilin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "diazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with METAXALONE.", "severity": 2}
{"drug1": "dapsone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with prednisone.", "severity": 2}
{"drug1": "reserpine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with phenytoin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with nalidixic acid.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Risedronic acid.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Agomelatine.", "severity": 2}
{"drug1": "morphine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with flunarizine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with carprofen.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "methysergide", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Topiroxostat.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with olanzapine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with xylometazoline.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with metoclopramide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with antipyrine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimethoprim is combined with dapsone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with terazosin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with norfloxacin.", "severity": 2}
{"drug1": "quinapril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with SERATRODAST.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with hydromorphone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with halothane.", "severity": 2}
{"drug1": "buspirone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with GUANFACINE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with clemastine.", "severity": 2}
{"drug1": "argatroban", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with diflunisal.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with Echothiophate.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with HEROIN.", "severity": 2}
{"drug1": "suprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with amcinonide.", "severity": 2}
{"drug1": "promazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with captopril.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Apremilast.", "severity": 2}
{"drug1": "suprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with clonidine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with propranolol.", "severity": 2}
{"drug1": "pramipexole", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with spironolactone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with mirtazapine.", "severity": 2}
{"drug1": "L-phenylalanine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when L-phenylalanine is combined with leflunomide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with glutethimide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with promethazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with clonazepam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Articaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Melatonin.", "severity": 2}
{"drug1": "hexetidine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with barnidipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with amisulpride.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with CLONIXIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with diphenhydramine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Loxoprofen.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with acemetacin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Droxicam.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with carisoprodol.", "severity": 2}
{"drug1": "furosemide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Metipranolol.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with barnidipine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with amitriptyline.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Torasemide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with isoxsuprine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Lurasidone.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with nalbuphine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with levorphanol.", "severity": 2}
{"drug1": "methadone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with carisoprodol.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with nicardipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with halothane.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with loxapine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Mirabegron.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with nicardipine.", "severity": 2}
{"drug1": "tiapride", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Pizotifen.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with GUANFACINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with atorvastatin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with thiamylal.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with sertraline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chlormezanone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Perospirone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Salsalate.", "severity": 2}
{"drug1": "betamethasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with fleroxacin.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with zotepine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ritonavir.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with propantheline.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with buspirone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with oxycodone.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with tizanidine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Clobetasone.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SODIUM BICARBONATE is combined with misoprostol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with captopril.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Vecuronium.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Lurasidone.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Propiverine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with chlorthalidone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with tiapride.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Retigabine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with secobarbital.", "severity": 2}
{"drug1": "clozapine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Pizotifen.", "severity": 2}
{"drug1": "diflunisal", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with equilin.", "severity": 2}
{"drug1": "tiagabine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with paroxetine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with trandolapril.", "severity": 2}
{"drug1": "sulindac", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Propacetamol.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "vindesine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with vindesine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with efavirenz.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with reserpine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with primidone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Perospirone.", "severity": 2}
{"drug1": "prazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Retigabine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Desloratadine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Clevidipine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "amifostine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with AMILORIDE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Eprosartan.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Etidronic acid.", "severity": 2}
{"drug1": "reserpine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with flurazepam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with alclometasone.", "severity": 2}
{"drug1": "morphine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nimodipine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with amisulpride.", "severity": 2}
{"drug1": "morphine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with sulpiride.", "severity": 2}
{"drug1": "procaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "morphine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with carisoprodol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with doxazosin.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Benidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with tizanidine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with papaverine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with mesoridazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with maprotiline.", "severity": 2}
{"drug1": "pramipexole", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with propranolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "thiamylal", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with fexofenadine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "ketamine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with nitrazepam.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with bromazepam.", "severity": 2}
{"drug1": "enflurane", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Fluspirilene.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Efonidipine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with amisulpride.", "severity": 2}
{"drug1": "triazolam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with loxapine.", "severity": 2}
{"drug1": "methysergide", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with metronidazole.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Lacidipine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with amisulpride.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "caffeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with caffeine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Quinupristin.", "severity": 2}
{"drug1": "benazepril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with salicylamide.", "severity": 2}
{"drug1": "pramipexole", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with captopril.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "azithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with azithromycin.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with buprenorphine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with etizolam.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with ritodrine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "tiapride", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with dantrolene.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with efavirenz.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Aliskiren.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with clorazepate.", "severity": 2}
{"drug1": "methysergide", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with nefazodone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Sitaxsentan.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Butylscopolamine.", "severity": 2}
{"drug1": "benztropine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with orphenadrine.", "severity": 2}
{"drug1": "azelastine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with diflunisal.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with tubocurarine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with rasagiline.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Aliskiren.", "severity": 2}
{"drug1": "methysergide", "drug2": "Telithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Telithromycin.", "severity": 2}
{"drug1": "methysergide", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with azelastine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with gabapentin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Normethadone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with penbutolol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Milnacipran.", "severity": 2}
{"drug1": "amifostine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with clomipramine.", "severity": 2}
{"drug1": "codeine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Pramocaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with butalbital.", "severity": 2}
{"drug1": "amifostine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with isocarboxazid.", "severity": 2}
{"drug1": "codeine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Propoxycaine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with felbamate.", "severity": 2}
{"drug1": "promethazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Fosphenytoin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with atorvastatin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with etizolam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with clomipramine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with chlorthalidone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Paliperidone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with chloral hydrate.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Retigabine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Agomelatine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with Echothiophate.", "severity": 2}
{"drug1": "leflunomide", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with medrysone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with felbamate.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with norfloxacin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with alclofenac.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with isoxsuprine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with xylometazoline.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with carvedilol.", "severity": 2}
{"drug1": "prazosin", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with cetirizine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with levodopa.", "severity": 2}
{"drug1": "procaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with physostigmine.", "severity": 2}
{"drug1": "trazodone", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with procarbazine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with memantine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with dantrolene.", "severity": 2}
{"drug1": "procarbazine", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with bupropion.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with rivastigmine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with amcinonide.", "severity": 2}
{"drug1": "fenbufen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with glutethimide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NEOSTIGMINE is combined with Cevimeline.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NEOSTIGMINE is combined with nicotine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with sertraline.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "oxycodone", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with butorphanol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with carisoprodol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with oxprenolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with dipyridamole.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "propofol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with proparacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Halazepam.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Pomalidomide.", "severity": 2}
{"drug1": "propofol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with indapamide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with methocarbamol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with methylphenidate.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with triprolidine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with triprolidine.", "severity": 2}
{"drug1": "promazine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with ketamine.", "severity": 2}
{"drug1": "timolol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with edrophonium.", "severity": 2}
{"drug1": "benzocaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with galanthamine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with benazepril.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Isoflurophate.", "severity": 2}
{"drug1": "flumethasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with mefloquine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with amoxapine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Olopatadine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with methocarbamol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Lofexidine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with tolmetin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with haloperidol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with mecamylamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Pizotifen.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with salicylic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Propacetamol.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with ethosuximide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with duloxetine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with dipyridamole.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Trospium.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with ESMOLOL.", "severity": 2}
{"drug1": "carprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Bretylium.", "severity": 2}
{"drug1": "methadone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with fexofenadine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Thioproperazine.", "severity": 2}
{"drug1": "Articaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with imipramine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with paroxetine.", "severity": 2}
{"drug1": "enflurane", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with tiapride.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Cis-mdp.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Levetiracetam.", "severity": 2}
{"drug1": "morphine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with apraclonidine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "miconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with bepridil.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Empagliflozin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Tolcapone.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with promazine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NEOSTIGMINE is combined with Varenicline.", "severity": 2}
{"drug1": "acemetacin", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with betamethasone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Lumiracoxib.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Atracurium besylate.", "severity": 2}
{"drug1": "morphine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with mepivacaine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Levocetirizine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Almotriptan.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with nitrazepam.", "severity": 2}
{"drug1": "floctafenine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with desoximetasone.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with nimesulide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with flumethasone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with flumethasone.", "severity": 2}
{"drug1": "terconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with gabapentin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with mesoridazine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with maprotiline.", "severity": 2}
{"drug1": "losartan", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Enalaprilat.", "severity": 2}
{"drug1": "triazolam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Perospirone.", "severity": 2}
{"drug1": "ethanol", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Milnacipran.", "severity": 2}
{"drug1": "trandolapril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with pramipexole.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Etidocaine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with enflurane.", "severity": 2}
{"drug1": "glutethimide", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with propoxyphene.", "severity": 2}
{"drug1": "triazolam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with methocarbamol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with baclofen.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with clemastine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with methazolamide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with venlafaxine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with proparacaine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with enalapril.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "iohexol", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when iohexol is combined with metformin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiludronic Acid is combined with Deferasirox.", "severity": 2}
{"drug1": "fosinopril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with terazosin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with methocarbamol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Lornoxicam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with ALFENTANIL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with timolol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with enflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Halazepam.", "severity": 2}
{"drug1": "zotepine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Normethadone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Empagliflozin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with fosinopril.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Fluprednidene.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Retigabine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Capsaicin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with clonidine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Halobetasol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with NAPROXEN.", "severity": 2}
{"drug1": "sotalol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with methyldopa.", "severity": 2}
{"drug1": "sotalol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with apraclonidine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Nebivolol.", "severity": 2}
{"drug1": "sotalol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Telmisartan.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "methysergide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with irbesartan.", "severity": 2}
{"drug1": "triazolam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Propoxycaine.", "severity": 2}
{"drug1": "morphine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with etizolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Pramocaine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "bepridil", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with cilnidipine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with bromocriptine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Desloratadine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with omeprazole.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with methscopolamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with dyclonine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with sulindac.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Sacubitril.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with chloroquine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with hydrocortisone.", "severity": 2}
{"drug1": "scopolamine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with dantrolene.", "severity": 2}
{"drug1": "rasagiline", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with apraclonidine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with ZILEUTON.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with edrophonium.", "severity": 2}
{"drug1": "butabarbital", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with trazodone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with CYCLIZINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with pentazocine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Iloperidone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with theobromine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with meclizine.", "severity": 2}
{"drug1": "meperidine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Zoledronic acid.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with dexamethasone.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Pipamperone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with felodipine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with selegiline.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with meclizine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Aceprometazine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with irbesartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with isoetharine.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with trifluoperazine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Lumiracoxib.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with butamben.", "severity": 2}
{"drug1": "cabergoline", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with propoxyphene.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with tizanidine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Bretylium.", "severity": 2}
{"drug1": "ritodrine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with nylidrin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Tolcapone.", "severity": 2}
{"drug1": "clozapine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Nitroprusside.", "severity": 2}
{"drug1": "cilazapril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with CLONIXIN.", "severity": 2}
{"drug1": "mesalamine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "equilin", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with pyridostigmine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with tolfenamic acid.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Gatifloxacin.", "severity": 2}
{"drug1": "cocaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with memantine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Clofarabine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Mirabegron.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ibuprofen.", "severity": 2}
{"drug1": "valsartan", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Apremilast.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with procaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "sertraline", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with clomipramine.", "severity": 2}
{"drug1": "clozapine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with fosinopril.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "folinic acid", "drug2": "5-Fluorouracil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when folinic acid is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with clozapine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Etidronic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with prednisone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "butabarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with butabarbital.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Metixene.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Tramadol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with methyclothiazide.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Doxercalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with Doxercalciferol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with hydralazine.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfisoxazole is combined with Flibanserin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with ethotoin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with tranylcypromine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with metoclopramide.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Echothiophate is combined with pilocarpine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with triflupromazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with clozapine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with floctafenine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with carisoprodol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Fencamfamin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Icatibant.", "severity": 2}
{"drug1": "amisulpride", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with primidone.", "severity": 2}
{"drug1": "halothane", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with etizolam.", "severity": 2}
{"drug1": "Salsalate", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with salicylamide.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with pravastatin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "butabarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with butabarbital.", "severity": 2}
{"drug1": "ropinirole", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with indapamide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chlorprothixene.", "severity": 2}
{"drug1": "chloroxine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with fenoprofen.", "severity": 2}
{"drug1": "clorazepate", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with propranolol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Halobetasol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with clonidine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with glutethimide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Almotriptan.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "propantheline", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Trospium.", "severity": 2}
{"drug1": "zidovudine", "drug2": "ribavirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zidovudine is combined with ribavirin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with amitriptyline.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Levomilnacipran.", "severity": 2}
{"drug1": "amisulpride", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with triprolidine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with budesonide.", "severity": 2}
{"drug1": "amisulpride", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with methocarbamol.", "severity": 2}
{"drug1": "amisulpride", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with methylphenidate.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with zotepine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with MELPERONE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "temazepam", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with nalbuphine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Clevidipine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with NITROUS ACID.", "severity": 2}
{"drug1": "promazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with brotizolam.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with oxycodone.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with codeine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with pentazocine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with enalapril.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with ROSOXACIN.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with methyclothiazide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with flunitrazepam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "apomorphine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with bepridil.", "severity": 2}
{"drug1": "cilazapril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with epoprostenol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with perphenazine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with trazodone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with levorphanol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with clidinium.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "formestane", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with decamethonium.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with isoetharine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with doxepin.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "abacavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with abacavir.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Normethadone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with loteprednol.", "severity": 2}
{"drug1": "enflurane", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with fludiazepam.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cobicistat is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Ropivacaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with bupivacaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with nefazodone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Etomidate.", "severity": 2}
{"drug1": "barnidipine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with clonidine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with propranolol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with diflorasone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Eprosartan.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with carisoprodol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Iloperidone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with bromocriptine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with sulpiride.", "severity": 2}
{"drug1": "meperidine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with triamterene.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with clonazepam.", "severity": 2}
{"drug1": "tretinoin", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with timolol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with propoxyphene.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with homoharringtonine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with clonazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with zonisamide.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with GUANFACINE.", "severity": 2}
{"drug1": "loratadine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with ondansetron.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with cocaine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with tiagabine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Flibanserin.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with nitrendipine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with droperidol.", "severity": 2}
{"drug1": "methadone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Normethadone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Agomelatine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with tiapride.", "severity": 2}
{"drug1": "Propiverine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with pyridostigmine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with gabapentin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with DESFLURANE.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyridostigmine is combined with Varenicline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with tiapride.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Cis-mdp.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with diflunisal.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Ciclesonide.", "severity": 2}
{"drug1": "linezolid", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Tapentadol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with protriptyline.", "severity": 2}
{"drug1": "metolazone", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with benazepril.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with cetirizine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with Pizotifen.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with dyclonine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Lornoxicam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Flibanserin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with glutethimide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with mitomycin C.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "vindesine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with vindesine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with paramethasone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with triprolidine.", "severity": 2}
{"drug1": "pimozide", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with MOLINDONE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Agomelatine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with benazepril.", "severity": 2}
{"drug1": "benazepril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with nitrous oxide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with alclofenac.", "severity": 2}
{"drug1": "barnidipine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "epirizole", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Estrone sulfate.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Levomilnacipran.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with GUANFACINE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Desloratadine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with mepivacaine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with scopolamine.", "severity": 2}
{"drug1": "quinapril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with oxaprozin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with nitrous oxide.", "severity": 2}
{"drug1": "benazepril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Apremilast.", "severity": 2}
{"drug1": "sotalol", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with propranolol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Ciclesonide.", "severity": 2}
{"drug1": "quinapril", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with PAMABROM.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "disopyramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with disopyramide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Aliskiren.", "severity": 2}
{"drug1": "baclofen", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with duloxetine.", "severity": 2}
{"drug1": "baclofen", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with fluoxetine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with carisoprodol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Escitalopram.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with NICORANDIL.", "severity": 2}
{"drug1": "clonidine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with ethotoin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Etoricoxib.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lopinavir is combined with meperidine.", "severity": 2}
{"drug1": "morphine", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with clorazepate.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with SERATRODAST.", "severity": 2}
{"drug1": "morphine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "morphine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nicardipine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "morphine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with efavirenz.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with mefenamic acid.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with digitoxin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Artemether", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Pregabalin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Etidronic acid.", "severity": 2}
{"drug1": "Articaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Articaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Escitalopram.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Epirubicin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with levodopa.", "severity": 2}
{"drug1": "pentazocine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with sevoflurane.", "severity": 2}
{"drug1": "zonisamide", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with promethazine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with sertraline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Acitretin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlortetracycline is combined with Acitretin.", "severity": 2}
{"drug1": "cetirizine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with paroxetine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with rasagiline.", "severity": 2}
{"drug1": "methadone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with clomipramine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Iloperidone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with nimesulide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with flunarizine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with citalopram.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Flupentixol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with tubocurarine.", "severity": 2}
{"drug1": "pimozide", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with butamben.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with ethosuximide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with captopril.", "severity": 2}
{"drug1": "amifostine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with cilnidipine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with phentolamine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with ouabain.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with acebutolol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with alclometasone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with vigabatrin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with aspirin.", "severity": 2}
{"drug1": "bumetanide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with risperidone.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Difenoxin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Epirubicin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Epirubicin is combined with clozapine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with HEROIN.", "severity": 2}
{"drug1": "thioridazine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Propacetamol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with scopolamine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with propofol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with estrone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with indapamide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Perospirone.", "severity": 2}
{"drug1": "halothane", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Pipotiazine.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Apremilast.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with butamben.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with budesonide.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with citalopram.", "severity": 2}
{"drug1": "Etomidate", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Pizotifen.", "severity": 2}
{"drug1": "furosemide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with irbesartan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Lornoxicam.", "severity": 2}
{"drug1": "furosemide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with felodipine.", "severity": 2}
{"drug1": "furosemide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "methadone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Torasemide.", "severity": 2}
{"drug1": "captopril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Loxoprofen.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Pregabalin.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Milnacipran.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with efavirenz.", "severity": 2}
{"drug1": "captopril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "captopril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Droxicam.", "severity": 2}
{"drug1": "floctafenine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with butalbital.", "severity": 2}
{"drug1": "epirizole", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with carvedilol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with NAPROXEN.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with mefenamic acid.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with flunitrazepam.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Lorcaserin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with PROCATEROL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with baclofen.", "severity": 2}
{"drug1": "rapamycin", "drug2": "cyclosporin A", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with cyclosporin A.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Apixaban.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Pipamperone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with betaxolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Phenelzine.", "severity": 2}
{"drug1": "selegiline", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with desipramine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Normethadone.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with gabapentin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Milnacipran.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with diltiazem.", "severity": 2}
{"drug1": "primidone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with thiopental.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Tapentadol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with BISOPROLOL.", "severity": 2}
{"drug1": "gabapentin", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with thiopental.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Teriflunomide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with clonazepam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with trimipramine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with nitroglycerin.", "severity": 2}
{"drug1": "tirofiban", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with ethosuximide.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Escitalopram.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Phenelzine.", "severity": 2}
{"drug1": "etizolam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with zonisamide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "topiramate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Pizotifen.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Etoricoxib.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyridostigmine is combined with methacholine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with citalopram.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Pipotiazine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "reserpine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with minoxidil.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with rizatriptan.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with HEROIN.", "severity": 2}
{"drug1": "trazodone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with mepivacaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with butalbital.", "severity": 2}
{"drug1": "topotecan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topotecan is combined with clozapine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with VERAPAMIL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Aliskiren.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with sevoflurane.", "severity": 2}
{"drug1": "cetirizine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with NICORANDIL.", "severity": 2}
{"drug1": "quazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with sulpiride.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Flibanserin.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with oxycodone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with tiapride.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Cis-mdp.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with topiramate.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Clevidipine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Desloratadine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with loratadine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with epirizole.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with irinotecan.", "severity": 2}
{"drug1": "butorphanol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with imipramine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with equilin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Lacidipine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with theobromine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Perospirone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Efonidipine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with cilnidipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with flunitrazepam.", "severity": 2}
{"drug1": "trazodone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with glutethimide.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with flurandrenolide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with D-mannitol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Phenelzine.", "severity": 2}
{"drug1": "valsartan", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ketorolac.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with prazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with quazepam.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Amrinone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with thiamylal.", "severity": 2}
{"drug1": "imipramine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with isoxsuprine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with D-mannitol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with halothane.", "severity": 2}
{"drug1": "haloperidol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "codeine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with risperidone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with mesoridazine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with HYDROCODONE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Eplerenone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with bumetanide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with meclizine.", "severity": 2}
{"drug1": "etodolac", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with resveratrol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with alclometasone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with mesoridazine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with ethosuximide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with scopolamine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with baclofen.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with AMILORIDE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Agomelatine.", "severity": 2}
{"drug1": "clonidine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with labetalol.", "severity": 2}
{"drug1": "clonidine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with quinapril.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with ethchlorvynol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ramipril.", "severity": 2}
{"drug1": "theophylline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when theophylline is combined with OLODATEROL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Fluspirilene.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Caspofungin.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Etomidate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with valsartan.", "severity": 2}
{"drug1": "levorphanol", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with bupivacaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Ropivacaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with methocarbamol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with mefenamic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with nisoldipine.", "severity": 2}
{"drug1": "zotepine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with topiramate.", "severity": 2}
{"drug1": "mesalamine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with flumethasone.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Tapentadol.", "severity": 2}
{"drug1": "selegiline", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with isoxsuprine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with decamethonium.", "severity": 2}
{"drug1": "chloroquine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "meperidine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Almotriptan.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with ritodrine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Amrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Amrubicin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "cytarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with cytarabine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with tolmetin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with indapamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with proparacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Halazepam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with scopolamine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with tizanidine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with hydrocortisone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "promethazine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with rasagiline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with pimozide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Mometasone.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with paroxetine.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Echothiophate is combined with acetylcholine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with nitrendipine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with alclometasone.", "severity": 2}
{"drug1": "SULFALENE", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SULFALENE is combined with dapsone.", "severity": 2}
{"drug1": "morphine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chlorprothixene.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with isoxsuprine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with norfloxacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Estrone sulfate.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Ropivacaine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Quinupristin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Pipamperone.", "severity": 2}
{"drug1": "propofol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Canagliflozin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Oxetacaine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Difenoxin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with dipyridamole.", "severity": 2}
{"drug1": "fosinopril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with azelastine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Ramelteon.", "severity": 2}
{"drug1": "triamterene", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Drospirenone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with rasagiline.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with lisinopril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ketamine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with prazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with zopiclone.", "severity": 2}
{"drug1": "etizolam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with scopolamine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Cevimeline.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with nicotine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with KETAZOLAM.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with carisoprodol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Etoricoxib.", "severity": 2}
{"drug1": "quazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with tiapride.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "midazolam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with tranylcypromine.", "severity": 2}
{"drug1": "midazolam", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with isoflurane.", "severity": 2}
{"drug1": "nicergoline", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "midazolam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with prilocaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Etidocaine.", "severity": 2}
{"drug1": "bepridil", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with nicardipine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with baclofen.", "severity": 2}
{"drug1": "butamben", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with diflorasone.", "severity": 2}
{"drug1": "metolazone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with D-mannitol.", "severity": 2}
{"drug1": "tioconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with MOLINDONE.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with Escitalopram.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Canagliflozin.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "etizolam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with MELPERONE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with imipramine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Aceprometazine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Agomelatine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with fexofenadine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with propofol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with tiapride.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "5-azacytidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with 5-azacytidine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with acemetacin.", "severity": 2}
{"drug1": "diazepam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Aripiprazole.", "severity": 2}
{"drug1": "atenolol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "BENZNIDAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with BENZNIDAZOLE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Clevidipine.", "severity": 2}
{"drug1": "procaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with efavirenz.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Difenoxin.", "severity": 2}
{"drug1": "Articaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with levodopa.", "severity": 2}
{"drug1": "proparacaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Lornoxicam.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Aripiprazole.", "severity": 2}
{"drug1": "atenolol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with felodipine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with D-mannitol.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "imipramine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with periciazine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with trazodone.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with levodopa.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with chloral hydrate.", "severity": 2}
{"drug1": "ondansetron", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with fludiazepam.", "severity": 2}
{"drug1": "methazolamide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "protriptyline", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with desipramine.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SIMEPREVIR is combined with oxycodone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with suprofen.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with primidone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "enalapril", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with periciazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "amsacrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with amsacrine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Indacaterol.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with etizolam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with etizolam.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with terazosin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Olopatadine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with nifedipine.", "severity": 2}
{"drug1": "doxepin", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with dobutamine.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "rapamycin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with ramipril.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with methyldopa.", "severity": 2}
{"drug1": "isradipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Bretylium.", "severity": 2}
{"drug1": "bumetanide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with fosinopril.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Desloratadine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Telmisartan.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with apraclonidine.", "severity": 2}
{"drug1": "risperidone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "benztropine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with HEROIN.", "severity": 2}
{"drug1": "halothane", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Torasemide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Escitalopram.", "severity": 2}
{"drug1": "flurazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "irbesartan", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with nifedipine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with moclobemide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with imipramine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Etidronic acid.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nitrazepam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with thiopental.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with diflorasone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with topiramate.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Fluspirilene.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with tetracaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with tiagabine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with cocaine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with maprotiline.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Echothiophate.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with zonisamide.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Almotriptan.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "benazepril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with quetiapine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with clidinium.", "severity": 2}
{"drug1": "oxycodone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with spironolactone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with methocarbamol.", "severity": 2}
{"drug1": "clidinium", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Desloratadine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with triprolidine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Potassium citrate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with mianserin.", "severity": 2}
{"drug1": "propantheline", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with oxybutynin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with apraclonidine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Torasemide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Iloperidone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with loteprednol.", "severity": 2}
{"drug1": "miconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with diltiazem.", "severity": 2}
{"drug1": "suprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with estrone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "dibucaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with paroxetine.", "severity": 2}
{"drug1": "estazolam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with zotepine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with amitriptyline.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Tolcapone.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with tubocurarine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with budesonide.", "severity": 2}
{"drug1": "enalapril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with sulfasalazine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with tizanidine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with furosemide.", "severity": 2}
{"drug1": "paroxetine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with clomipramine.", "severity": 2}
{"drug1": "estazolam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with MELPERONE.", "severity": 2}
{"drug1": "bepridil", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Indacaterol.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with apraclonidine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Telmisartan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with clozapine.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dabigatran etexilate is combined with meperidine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with chlorothiazide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with bumetanide.", "severity": 2}
{"drug1": "Trospium", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with methadone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Phenelzine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with GUANFACINE.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with nadolol.", "severity": 2}
{"drug1": "Trospium", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with oxybutynin.", "severity": 2}
{"drug1": "baclofen", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with topiramate.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Deferasirox.", "severity": 2}
{"drug1": "Normethadone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with metolazone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Methadyl acetate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Echothiophate.", "severity": 2}
{"drug1": "halothane", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with apraclonidine.", "severity": 2}
{"drug1": "halothane", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Telmisartan.", "severity": 2}
{"drug1": "halothane", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Desloratadine.", "severity": 2}
{"drug1": "halothane", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with methyldopa.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Melatonin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Pipamperone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with medrysone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Cyamemazine.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM OXIDE is combined with misoprostol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with clomipramine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with indapamide.", "severity": 2}
{"drug1": "risperidone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with cetirizine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with digitoxin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with sulfasalazine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "cisplatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with cisplatin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "flurazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EDOXABAN is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with zaltoprofen.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Aceclofenac.", "severity": 2}
{"drug1": "sotalol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with cilazapril.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with acebutolol.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with SERATRODAST.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Oxetacaine.", "severity": 2}
{"drug1": "sulindac", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with betamethasone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with tiagabine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with zonisamide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with lidocaine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ticagrelor is combined with Apixaban.", "severity": 2}
{"drug1": "lidocaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with baclofen.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with potassium ion.", "severity": 2}
{"drug1": "benzocaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with lithium ion.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with formestane.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Lorcaserin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with papaverine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Zoledronic acid.", "severity": 2}
{"drug1": "methazolamide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "codeine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with butorphanol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Agomelatine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with formestane.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Canagliflozin.", "severity": 2}
{"drug1": "selegiline", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with dipivefrin.", "severity": 2}
{"drug1": "loxapine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Ropivacaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with bupivacaine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "loxapine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Etomidate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "topiramate", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with meclizine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with dextromethorphan.", "severity": 2}
{"drug1": "alclometasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "cerulenin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with felodipine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Efonidipine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Lacidipine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Benidipine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Azelnidipine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with cilnidipine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Oxetacaine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with brotizolam.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Torasemide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "butorphanol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with etizolam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with prazepam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "levorphanol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with dantrolene.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "loxapine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Pipotiazine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with citalopram.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with chlorzoxazone.", "severity": 2}
{"drug1": "clozapine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with trandolapril.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with mesoridazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with raloxifene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with maprotiline.", "severity": 2}
{"drug1": "loxapine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with scopolamine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with fluoxetine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with cinoxacin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with duloxetine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with quetiapine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with amoxapine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Zoledronic acid.", "severity": 2}
{"drug1": "propofol", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nitrous oxide.", "severity": 2}
{"drug1": "codeine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Torasemide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with cetirizine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Remoxipride.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with tizanidine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with ethosuximide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with fluoxetine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with Calcifediol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with mefenamic acid.", "severity": 2}
{"drug1": "sulconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Desloratadine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with bromazepam.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with levorphanol.", "severity": 2}
{"drug1": "methadone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with GUANFACINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Iloperidone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with cabergoline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with halothane.", "severity": 2}
{"drug1": "sertraline", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with zotepine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with nimesulide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with diazepam.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Perospirone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Fluspirilene.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Propacetamol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nadolol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with quetiapine.", "severity": 2}
{"drug1": "meperidine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with furosemide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "RUCAPARIB", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with RUCAPARIB.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with dyclonine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with thiopental.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "amiodarone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclophosphamide is combined with amiodarone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Lomitapide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with topiramate.", "severity": 2}
{"drug1": "ramipril", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with benazepril.", "severity": 2}
{"drug1": "diazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with trazodone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with tizanidine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Trospium.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with furosemide.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eluxadoline is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "propofol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with METAXALONE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with zopiclone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with isocarboxazid.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Fencamfamin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with oxymorphone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with felodipine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Pramocaine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Riociguat.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with procarbazine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with phenytoin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with fluocinonide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with prednisone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with terazosin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with paramethasone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "propranolol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with losartan.", "severity": 2}
{"drug1": "prazosin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with fosinopril.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "bromazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with imipramine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with methyclothiazide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "dapsone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with zopiclone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with dexamethasone.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with pentazocine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with CARTEOLOL.", "severity": 2}
{"drug1": "buspirone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with meclizine.", "severity": 2}
{"drug1": "buspirone", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with risperidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with oxprenolol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with loratadine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with periciazine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with fludiazepam.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with antipyrine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with terbutaline.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with chloral hydrate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Fencamfamin.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Clevidipine.", "severity": 2}
{"drug1": "losartan", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with dipyridamole.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Remoxipride.", "severity": 2}
{"drug1": "isradipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with memantine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "propranolol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with enalapril.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with levodopa.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with sevoflurane.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Aripiprazole.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Doxercalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with Doxercalciferol.", "severity": 2}
{"drug1": "estazolam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with amoxapine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with vinorelbine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with ergocalciferol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Carbetocin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Pipamperone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Levocetirizine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with oxprenolol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with prazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with sevoflurane.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with levodopa.", "severity": 2}
{"drug1": "barnidipine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with GUANFACINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Ramelteon.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Iloperidone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with vigabatrin.", "severity": 2}
{"drug1": "morphine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Nebivolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "enflurane", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with thiamylal.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Pentolinium.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Lornoxicam.", "severity": 2}
{"drug1": "enflurane", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with halothane.", "severity": 2}
{"drug1": "indomethacin", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with alclometasone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Ticagrelor.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Lurasidone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with fexofenadine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Lormetazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with baclofen.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with procaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with trimipramine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with propofol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "diazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with dantrolene.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "perphenazine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with oxprenolol.", "severity": 2}
{"drug1": "butalbital", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with efavirenz.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with selegiline.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with amitriptyline.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Tolcapone.", "severity": 2}
{"drug1": "diazepam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with estazolam.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with halcinonide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with quinapril.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with difluprednate.", "severity": 2}
{"drug1": "thiopental", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with triamcinolone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with quetiapine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with mefloquine.", "severity": 2}
{"drug1": "morphine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with perphenazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with ethosuximide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with dantrolene.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Olopatadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with thiopental.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Aceclofenac.", "severity": 2}
{"drug1": "metolazone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Ramelteon.", "severity": 2}
{"drug1": "ketorolac", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with sulindac.", "severity": 2}
{"drug1": "perphenazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with benazepril.", "severity": 2}
{"drug1": "meperidine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with enflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Ketobemidone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with chloroquine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Fosphenytoin.", "severity": 2}
{"drug1": "isradipine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with methyldopa.", "severity": 2}
{"drug1": "isradipine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Telmisartan.", "severity": 2}
{"drug1": "isradipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with apraclonidine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nimodipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with levorphanol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Fospropofol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Normethadone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with ondansetron.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with nimodipine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with tiagabine.", "severity": 2}
{"drug1": "thiopental", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with baclofen.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Eplerenone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with zonisamide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Oxetacaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Lorcaserin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when decamethonium is combined with Carbamylcholine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with hydromorphone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Articaine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Droxicam.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with CLONIXIN.", "severity": 2}
{"drug1": "cocaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sorafenib is combined with atorvastatin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with fleroxacin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with chlormezanone.", "severity": 2}
{"drug1": "labetalol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with cilazapril.", "severity": 2}
{"drug1": "Halazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with chlorthalidone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Deferasirox.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "oxazepam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with DESFLURANE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Metipranolol.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Fosphenytoin.", "severity": 2}
{"drug1": "clozapine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with oxprenolol.", "severity": 2}
{"drug1": "clozapine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "pimozide", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with methyclothiazide.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Flibanserin.", "severity": 2}
{"drug1": "thiopental", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with oxprenolol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with VERAPAMIL.", "severity": 2}
{"drug1": "brotizolam", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "cetirizine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "desipramine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with Mephobarbital.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Naftifine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with haloperidol.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Tasimelteon.", "severity": 2}
{"drug1": "procaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with DESONIDE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with terazosin.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with tolmetin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Etidronic acid.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Escitalopram.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with cyclophosphamide.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with citalopram.", "severity": 2}
{"drug1": "thioridazine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with papaverine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Pizotifen.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with cetirizine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with fenoldopam.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with protriptyline.", "severity": 2}
{"drug1": "terbinafine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with cilnidipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with mesoridazine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with indapamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with maprotiline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with pimozide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with methylprednisolone.", "severity": 2}
{"drug1": "clozapine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with dantrolene.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with reserpine.", "severity": 2}
{"drug1": "manidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when manidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "meprobamate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with topiramate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "thalidomide", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with labetalol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Levocetirizine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ticlopidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with ticlopidine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with etizolam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Eszopiclone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with doxazosin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with amisulpride.", "severity": 2}
{"drug1": "thalidomide", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with AMILORIDE.", "severity": 2}
{"drug1": "buspirone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with flunarizine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with duloxetine.", "severity": 2}
{"drug1": "buspirone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "procaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with clonazepam.", "severity": 2}
{"drug1": "epirizole", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with alclometasone.", "severity": 2}
{"drug1": "Metixene", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with oxycodone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with benzocaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with vigabatrin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with apraclonidine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Articaine.", "severity": 2}
{"drug1": "benazepril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with maprotiline.", "severity": 2}
{"drug1": "Butethal", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with MELPERONE.", "severity": 2}
{"drug1": "halothane", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Retigabine.", "severity": 2}
{"drug1": "aspirin", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with loteprednol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with meclizine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with METAXALONE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with dantrolene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Normethadone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Fospropofol.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with METAXALONE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with tetracaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with amoxapine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with bupivacaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Ropivacaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with morphine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with isoxsuprine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with tiagabine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with zonisamide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Fluspirilene.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with midazolam.", "severity": 2}
{"drug1": "Limaprost", "drug2": "tirofiban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with tirofiban.", "severity": 2}
{"drug1": "naratriptan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with chlorprothixene.", "severity": 2}
{"drug1": "zopiclone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with tiapride.", "severity": 2}
{"drug1": "imipramine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with acebutolol.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Lornoxicam.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with flurandrenolide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Ketobemidone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with mefenamic acid.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with spironolactone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with imipramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with dantrolene.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with cinnarizine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Ethylmorphine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with oxymorphone.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Pipamperone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Fencamfamin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with tubocurarine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with brotizolam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with felbamate.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "metolazone", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Aliskiren.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with apraclonidine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with Milnacipran.", "severity": 2}
{"drug1": "amifostine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with diltiazem.", "severity": 2}
{"drug1": "docetaxel", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with topotecan.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Salbutamol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "6-Mercaptopurine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with triazolam.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with ESMOLOL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Perospirone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with NITROUS ACID.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Flibanserin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Pimecrolimus.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Salbutamol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with timolol.", "severity": 2}
{"drug1": "butalbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with maprotiline.", "severity": 2}
{"drug1": "Naftifine", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with cinnarizine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Articaine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Olopatadine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with mecamylamine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with METAXALONE.", "severity": 2}
{"drug1": "pargyline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with OLODATEROL.", "severity": 2}
{"drug1": "captopril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with floctafenine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Mometasone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with zafirlukast.", "severity": 2}
{"drug1": "promazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "carprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with vincristine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Lormetazepam.", "severity": 2}
{"drug1": "promazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with DESONIDE.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Icatibant.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Iloperidone.", "severity": 2}
{"drug1": "timolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with cilazapril.", "severity": 2}
{"drug1": "cocaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with brotizolam.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with meperidine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Articaine.", "severity": 2}
{"drug1": "codeine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with indapamide.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with pentazocine.", "severity": 2}
{"drug1": "methysergide", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with progesterone.", "severity": 2}
{"drug1": "suprofen", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with oxaprozin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Butethal.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Hexobarbital.", "severity": 2}
{"drug1": "aspirin", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with fluocinonide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with alclofenac.", "severity": 2}
{"drug1": "paramethasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with malathion.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with clidinium.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with mecamylamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Conivaptan.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with resveratrol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with tolfenamic acid.", "severity": 2}
{"drug1": "nicergoline", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with buprenorphine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Pipamperone.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atorvastatin is combined with spironolactone.", "severity": 2}
{"drug1": "meperidine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with AMILORIDE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with papaverine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with amitriptyline.", "severity": 2}
{"drug1": "enalapril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with procarbazine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with prednisone.", "severity": 2}
{"drug1": "Trospium", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with zonisamide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with phentolamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "estrone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with edrophonium.", "severity": 2}
{"drug1": "lorazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with baclofen.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with furosemide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with daunorubicin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Pipamperone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with sulfasalazine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with nifedipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Vilanterol.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with fluocinonide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with carisoprodol.", "severity": 2}
{"drug1": "sulindac", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with chloroquine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Lornoxicam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with tolfenamic acid.", "severity": 2}
{"drug1": "HEROIN", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Ramelteon.", "severity": 2}
{"drug1": "codeine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with midazolam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with penbutolol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with glutethimide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with norfloxacin.", "severity": 2}
{"drug1": "ketamine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Cariprazine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Perospirone.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with citalopram.", "severity": 2}
{"drug1": "ketamine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with bromazepam.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Echothiophate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Oxetacaine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with benzocaine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Enalaprilat.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "halothane", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Levetiracetam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with alclofenac.", "severity": 2}
{"drug1": "promazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Pizotifen.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with trandolapril.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Difenoxin.", "severity": 2}
{"drug1": "valsartan", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Propacetamol.", "severity": 2}
{"drug1": "ketamine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with benzocaine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Etoricoxib.", "severity": 2}
{"drug1": "ketamine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with vigabatrin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with fexofenadine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with bumetanide.", "severity": 2}
{"drug1": "Butethal", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with MOLINDONE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "dacarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with dacarbazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "temozolomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with temozolomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "5-Aminolevulinic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with 5-Aminolevulinic acid.", "severity": 2}
{"drug1": "methysergide", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with bifonazole.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with NITROUS ACID.", "severity": 2}
{"drug1": "trimipramine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with vigabatrin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with OLODATEROL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Vilanterol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norfloxacin is combined with atorvastatin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with flunitrazepam.", "severity": 2}
{"drug1": "clomipramine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with acebutolol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with gemfibrozil.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "loxapine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with haloperidol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with docetaxel.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Milnacipran.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with butamben.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with carprofen.", "severity": 2}
{"drug1": "sulfanilamide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfanilamide is combined with atorvastatin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Salsalate.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with bupivacaine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Etomidate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with atorvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with bicalutamide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with rabeprazole.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Pizotifen.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with HYDROCODONE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Propacetamol.", "severity": 2}
{"drug1": "etizolam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Pipotiazine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Icatibant", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with CLONIXIN.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with metaproterenol.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Lornoxicam.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with risperidone.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with methadone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with flurbiprofen.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Difenoxin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "zaleplon", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "ipratropium", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with cyclopentolate.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with homoharringtonine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with prazepam.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with procaine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with triprolidine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with methocarbamol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Etoricoxib.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Ramelteon.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with daunorubicin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosamprenavir is combined with Flibanserin.", "severity": 2}
{"drug1": "etizolam", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with venlafaxine.", "severity": 2}
{"drug1": "etizolam", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with clemastine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with mesoridazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with prazosin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with diflunisal.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Tixocortol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "leflunomide", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with desoximetasone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with nadolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with MELPERONE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with zotepine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with methoxyflurane.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with indapamide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Lurasidone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with ramipril.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with valsartan.", "severity": 2}
{"drug1": "procyclidine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "propantheline", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with oxycodone.", "severity": 2}
{"drug1": "Articaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with tiagabine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with METAXALONE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with duloxetine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with pimozide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Pomalidomide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with bupropion.", "severity": 2}
{"drug1": "Salsalate", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with diflorasone.", "severity": 2}
{"drug1": "midazolam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with prazepam.", "severity": 2}
{"drug1": "propofol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with chlorthalidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with amitriptyline.", "severity": 2}
{"drug1": "propofol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with alclometasone.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with barnidipine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with D-mannitol.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with oxaprozin.", "severity": 2}
{"drug1": "risperidone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with dibucaine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with trimipramine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with rescinnamine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with tolfenamic acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with fludrocortisone.", "severity": 2}
{"drug1": "quazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Articaine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with Levocetirizine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with butamben.", "severity": 2}
{"drug1": "protriptyline", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with methyldopa.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with zotepine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with apraclonidine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with doxepin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Belinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Belinostat.", "severity": 2}
{"drug1": "Etomidate", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with amisulpride.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with clomipramine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with paroxetine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "sulconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Levocetirizine.", "severity": 2}
{"drug1": "temazepam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with zaleplon.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Retigabine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with protriptyline.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with VERAPAMIL.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with cetirizine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Methadyl acetate.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with glutethimide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Oxetacaine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with citalopram.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Escitalopram.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with fleroxacin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with chlormezanone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with bromazepam.", "severity": 2}
{"drug1": "chloroquine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with paramethasone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with amitriptyline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with ethosuximide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with dibucaine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with promethazine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with clonazepam.", "severity": 2}
{"drug1": "diflunisal", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with SERATRODAST.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with fenoprofen.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Difenoxin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Milnacipran.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with selegiline.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with haloperidol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with zonisamide.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with tizanidine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with ondansetron.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with tiagabine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with cocaine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Fluspirilene.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with citalopram.", "severity": 2}
{"drug1": "methazolamide", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with dorzolamide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with clenbuterol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with sulpiride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nimodipine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with quinapril.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with mefloquine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Ropivacaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with bupivacaine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with bumetanide.", "severity": 2}
{"drug1": "Droxicam", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with loteprednol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Levocetirizine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with doxepin.", "severity": 2}
{"drug1": "Trospium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with topiramate.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with hydromorphone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with fludrocortisone.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with citalopram.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with quetiapine.", "severity": 2}
{"drug1": "estazolam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Levocetirizine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with DESONIDE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Lornoxicam.", "severity": 2}
{"drug1": "doxylamine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with Milnacipran.", "severity": 2}
{"drug1": "glutethimide", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with amisulpride.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Potassium citrate.", "severity": 2}
{"drug1": "tolterodine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with HEROIN.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Agomelatine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with enflurane.", "severity": 2}
{"drug1": "meperidine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with prilocaine.", "severity": 2}
{"drug1": "meperidine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with isoflurane.", "severity": 2}
{"drug1": "meperidine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ethotoin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Risedronic acid.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with oxyphenonium.", "severity": 2}
{"drug1": "risperidone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "levodopa", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with flunarizine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Milnacipran.", "severity": 2}
{"drug1": "pimozide", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Difenoxin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Fluspirilene.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with DESONIDE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Fluprednidene.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with cilazapril.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with meclizine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with diltiazem.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "valsartan", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with labetalol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "valsartan", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with AMILORIDE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Aceclofenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with nifedipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with chloral hydrate.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with fludiazepam.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Pomalidomide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with papaverine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with meclofenamic acid.", "severity": 2}
{"drug1": "benzocaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with trimipramine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with domperidone.", "severity": 2}
{"drug1": "sertraline", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with mirtazapine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with primidone.", "severity": 2}
{"drug1": "estazolam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with felbamate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with decamethonium.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with Paricalcitol.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with Demecarium.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with thalidomide.", "severity": 2}
{"drug1": "imipramine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with tiagabine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with trandolapril.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Desloratadine.", "severity": 2}
{"drug1": "baclofen", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Milnacipran.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with theobromine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with nitric oxide.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "felodipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with quetiapine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with flunarizine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with topiramate.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with flunarizine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with nitrous oxide.", "severity": 2}
{"drug1": "zotepine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with doxepin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with chlorothiazide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with ifosfamide.", "severity": 2}
{"drug1": "imipramine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with zonisamide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Clodronic Acid.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with nimodipine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with primidone.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Fesoterodine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with moclobemide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with digitoxin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with GUANFACINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with chlormezanone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Pipamperone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Tapentadol.", "severity": 2}
{"drug1": "diazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Aceclofenac.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Pramocaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with SERATRODAST.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with promethazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with promethazine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with clonazepam.", "severity": 2}
{"drug1": "amisulpride", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with felbamate.", "severity": 2}
{"drug1": "felbamate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Tasimelteon.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with carisoprodol.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "codeine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with sulpiride.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with ketoprofen.", "severity": 2}
{"drug1": "temazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with baclofen.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with tranylcypromine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PRIMAQUINE is combined with prilocaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Pramocaine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with promethazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Propoxycaine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with triamcinolone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with trifluoperazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with rabeprazole.", "severity": 2}
{"drug1": "pergolide", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with bicalutamide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Ditazole.", "severity": 2}
{"drug1": "temazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with prazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with dexamethasone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with MOLINDONE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with clonidine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with methocarbamol.", "severity": 2}
{"drug1": "zotepine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with clidinium.", "severity": 2}
{"drug1": "glutethimide", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with triprolidine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with carisoprodol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with sulpiride.", "severity": 2}
{"drug1": "butabarbital", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with clozapine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nimodipine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Aceclofenac.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with protriptyline.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with flunitrazepam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Metixene", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with HEROIN.", "severity": 2}
{"drug1": "celecoxib", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "desipramine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Thioproperazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with felbamate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Flupentixol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with epirizole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with trazodone.", "severity": 2}
{"drug1": "meperidine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with efavirenz.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "benazepril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Nebivolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with metoprolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with amisulpride.", "severity": 2}
{"drug1": "prazosin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Empagliflozin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with GUANFACINE.", "severity": 2}
{"drug1": "felbamate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with desipramine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with diflunisal.", "severity": 2}
{"drug1": "ramipril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "prazosin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with trandolapril.", "severity": 2}
{"drug1": "ramipril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with felodipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Oxetacaine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with desoximetasone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with trandolapril.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with felbamate.", "severity": 2}
{"drug1": "clozapine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with methazolamide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Eplerenone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "captopril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "clozapine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Pipamperone.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with tubocurarine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with atorvastatin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with zonisamide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Drospirenone.", "severity": 2}
{"drug1": "epinephrine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with benzphetamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "epinephrine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with ritodrine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with tetracaine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with methazolamide.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with medrysone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with AMILORIDE.", "severity": 2}
{"drug1": "methadone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ketamine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Riociguat.", "severity": 2}
{"drug1": "sulconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with bepridil.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with flunarizine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Lurasidone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with sotalol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with digitoxin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with phenytoin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with brimonidine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with nitroglycerin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with celecoxib.", "severity": 2}
{"drug1": "Articaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with brotizolam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with fludiazepam.", "severity": 2}
{"drug1": "scopolamine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with flunarizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with GUANFACINE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with halcinonide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with clonidine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with nifedipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with CLONIXIN.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Olopatadine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with isocarboxazid.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with prednisone.", "severity": 2}
{"drug1": "ramipril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Droxicam.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Clofarabine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with zaltoprofen.", "severity": 2}
{"drug1": "nabumetone", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with SERATRODAST.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Mephobarbital.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with clidinium.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with hydralazine.", "severity": 2}
{"drug1": "captopril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Olopatadine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with metolazone.", "severity": 2}
{"drug1": "quinapril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with diclofenac.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with fludiazepam.", "severity": 2}
{"drug1": "benazepril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Aceclofenac.", "severity": 2}
{"drug1": "zopiclone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with doxepin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Iloperidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with simvastatin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Apremilast.", "severity": 2}
{"drug1": "nicergoline", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with propoxyphene.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with felodipine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "brotizolam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with ethotoin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Pralatrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Pralatrexate.", "severity": 2}
{"drug1": "reserpine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Pipamperone.", "severity": 2}
{"drug1": "reserpine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with clonazepam.", "severity": 2}
{"drug1": "buspirone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with felbamate.", "severity": 2}
{"drug1": "reserpine", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with prochlorperazine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Ketobemidone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Etidronic acid.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with ouabain.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with terazosin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with pentazocine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with Gemifloxacin.", "severity": 2}
{"drug1": "methysergide", "drug2": "Lopinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Lopinavir.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with tretinoin.", "severity": 2}
{"drug1": "Retigabine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "benazepril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with SERATRODAST.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with lithium ion.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Hexobarbital.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Butethal.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with reserpine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Clevidipine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with fludiazepam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with selegiline.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with pramipexole.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with tranylcypromine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with isoflurane.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with phenytoin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with dapsone.", "severity": 2}
{"drug1": "zotepine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "amifostine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with doxepin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with periciazine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with toremifene.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Normethadone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Nebivolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with promethazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Efonidipine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Lacidipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nadolol.", "severity": 2}
{"drug1": "barnidipine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with bromocriptine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with MELPERONE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with ZILEUTON.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Milnacipran.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with propoxyphene.", "severity": 2}
{"drug1": "aspirin", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Pomalidomide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with thioridazine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with trifluoperazine.", "severity": 2}
{"drug1": "cocaine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with atorvastatin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Etidronic acid.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "diazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Avanafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vardenafil is combined with Avanafil.", "severity": 2}
{"drug1": "morphine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with codeine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Levocetirizine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with tiapride.", "severity": 2}
{"drug1": "morphine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Tolcapone.", "severity": 2}
{"drug1": "morphine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chlorthalidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with fexofenadine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with mycophenolic acid.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Torasemide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with loteprednol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Apixaban.", "severity": 2}
{"drug1": "thiopental", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "prazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with ambenonium.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Fluprednidene.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Clevidipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with sertraline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with isradipine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with fleroxacin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "loxapine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Propoxycaine.", "severity": 2}
{"drug1": "atenolol", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with alclofenac.", "severity": 2}
{"drug1": "topiramate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with fexofenadine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Doxercalciferol is combined with Paricalcitol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Valrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Valrubicin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with mesoridazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with maprotiline.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with paramethasone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "suprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "aspirin", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Clobetasone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with labetalol.", "severity": 2}
{"drug1": "thiopental", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with carisoprodol.", "severity": 2}
{"drug1": "diazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "halothane", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Oxetacaine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with doxazosin.", "severity": 2}
{"drug1": "losartan", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Loxoprofen.", "severity": 2}
{"drug1": "HEROIN", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with chlorpheniramine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Pramocaine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Propoxycaine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "biperiden", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with HYDROCODONE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Milnacipran.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Fosphenytoin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with ZILEUTON.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with halothane.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Risedronic acid.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "quazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with enflurane.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Metipranolol.", "severity": 2}
{"drug1": "temazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyamphetamine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with tiapride.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with edrophonium.", "severity": 2}
{"drug1": "isoflurane", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with KETAZOLAM.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with nadolol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Articaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Pomalidomide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Agomelatine.", "severity": 2}
{"drug1": "prazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with clozapine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with nadolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with flurbiprofen.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with dipyridamole.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "enalapril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ADAPALENE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Pizotifen.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with scopolamine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with alclofenac.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with lovastatin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with zaltoprofen.", "severity": 2}
{"drug1": "fosinopril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Clodronic Acid.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Olopatadine.", "severity": 2}
{"drug1": "reserpine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nitrous oxide.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ivacaftor is combined with atorvastatin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with irinotecan.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Levetiracetam.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Ketobemidone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Oxetacaine.", "severity": 2}
{"drug1": "papaverine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "tolazoline", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with papaverine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with nifedipine.", "severity": 2}
{"drug1": "enflurane", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with triflupromazine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with felodipine.", "severity": 2}
{"drug1": "quazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "doxepin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Pizotifen.", "severity": 2}
{"drug1": "quazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "quazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Empagliflozin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with dichlorphenamide.", "severity": 2}
{"drug1": "sulindac", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with NITROUS ACID.", "severity": 2}
{"drug1": "aspirin", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with salicylic acid.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Deferasirox.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with leflunomide.", "severity": 2}
{"drug1": "enflurane", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with imipramine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with leflunomide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with desipramine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with flunarizine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with carisoprodol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "pentostatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with pentostatin.", "severity": 2}
{"drug1": "biperiden", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with levorphanol.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lapatinib is combined with atorvastatin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Empagliflozin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Tasimelteon.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with meperidine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with methazolamide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with droperidol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with dibucaine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with halcinonide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Icatibant.", "severity": 2}
{"drug1": "methadone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with imipramine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with spironolactone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Halobetasol.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Trovafloxacin.", "severity": 2}
{"drug1": "furosemide", "drug2": "paromomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with paromomycin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with flurazepam.", "severity": 2}
{"drug1": "dyclonine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with tizanidine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Demecarium.", "severity": 2}
{"drug1": "procaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with scopolamine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "isradipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with nadolol.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with topiramate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Frovatriptan.", "severity": 2}
{"drug1": "thiopental", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with proparacaine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with papaverine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with chlorzoxazone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with salicylamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Methadyl acetate.", "severity": 2}
{"drug1": "reserpine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with glutethimide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with zotepine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with MELPERONE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Oxetacaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with oxazepam.", "severity": 2}
{"drug1": "tropicamide", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with hyoscyamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Alvimopan.", "severity": 2}
{"drug1": "docetaxel", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with sparfloxacin.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Isoflurophate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with lomustine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with mitoxantrone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with edrophonium.", "severity": 2}
{"drug1": "nefazodone", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with loxapine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Remoxipride.", "severity": 2}
{"drug1": "ethanol", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with methylphenidate.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with alclofenac.", "severity": 2}
{"drug1": "estazolam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with bromazepam.", "severity": 2}
{"drug1": "azelastine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Mometasone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with carvedilol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with dantrolene.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with topiramate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with terazosin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with clonidine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with amisulpride.", "severity": 2}
{"drug1": "etizolam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Pomalidomide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Pipamperone.", "severity": 2}
{"drug1": "physostigmine", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when physostigmine is combined with nicotine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when physostigmine is combined with Cevimeline.", "severity": 2}
{"drug1": "tolmetin", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with dexamethasone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with sertraline.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Pipamperone.", "severity": 2}
{"drug1": "procyclidine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with meperidine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Olmesartan.", "severity": 2}
{"drug1": "risperidone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with tetracaine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with doxazosin.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with terazosin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with chlorthalidone.", "severity": 2}
{"drug1": "bepridil", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with oxybutynin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Ketobemidone.", "severity": 2}
{"drug1": "meperidine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Efonidipine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Ketobemidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with desipramine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with Demecarium.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with butamben.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Fospropofol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with BISOPROLOL.", "severity": 2}
{"drug1": "timolol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with trimipramine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with chlormezanone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "medrysone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with enoxacin.", "severity": 2}
{"drug1": "propofol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "cetirizine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with levodopa.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Riociguat.", "severity": 2}
{"drug1": "trandolapril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with CLONIXIN.", "severity": 2}
{"drug1": "flumethasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with donepezil.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with fluvastatin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Loxoprofen.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Rosuvastatin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with etizolam.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with loratadine.", "severity": 2}
{"drug1": "etodolac", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with equilin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Droxicam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with prilocaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with mecamylamine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with trazodone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Cis-mdp.", "severity": 2}
{"drug1": "valsartan", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with nifedipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with tranylcypromine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "estrone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with sparfloxacin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Tramadol.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ethotoin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Ticagrelor.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Levetiracetam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Bretylium.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with halothane.", "severity": 2}
{"drug1": "temazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with cetirizine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Paliperidone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with thiamylal.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with promethazine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with gabapentin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with moclobemide.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "Butethal", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with nefazodone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with dipyridamole.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with duloxetine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with chlormezanone.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with bepridil.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with D-mannitol.", "severity": 2}
{"drug1": "Butethal", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with doxepin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Retigabine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with nilvadipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Propoxycaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with amobarbital.", "severity": 2}
{"drug1": "metoprolol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with losartan.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Pramocaine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with thalidomide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Hexobarbital.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Clevidipine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Lormetazepam.", "severity": 2}
{"drug1": "pentamidine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with diltiazem.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Butethal.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with galanthamine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Isoflurophate.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Metipranolol.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with terazosin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with pramipexole.", "severity": 2}
{"drug1": "prilocaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Metipranolol.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with vigabatrin.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with fluvastatin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with etodolac.", "severity": 2}
{"drug1": "floctafenine", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with suprofen.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Difenoxin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with loteprednol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Milnacipran.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Lurasidone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with lithium ion.", "severity": 2}
{"drug1": "terconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with nimodipine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Amrinone.", "severity": 2}
{"drug1": "etizolam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with thiamylal.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with desipramine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with oxymorphone.", "severity": 2}
{"drug1": "terbutaline", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with nylidrin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with halothane.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Bretylium.", "severity": 2}
{"drug1": "midazolam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Difenoxin.", "severity": 2}
{"drug1": "labetalol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "triazolam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with doxepin.", "severity": 2}
{"drug1": "labetalol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ramipril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with quetiapine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with antipyrine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Avanafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tadalafil is combined with Avanafil.", "severity": 2}
{"drug1": "dibucaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with sertraline.", "severity": 2}
{"drug1": "triamterene", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with enalapril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ifosfamide is combined with leflunomide.", "severity": 2}
{"drug1": "ketamine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with scopolamine.", "severity": 2}
{"drug1": "estazolam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with olanzapine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with efavirenz.", "severity": 2}
{"drug1": "propofol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "propofol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with aspirin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with hydralazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ritodrine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Metipranolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with estazolam.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with loratadine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Paliperidone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with maprotiline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with felodipine.", "severity": 2}
{"drug1": "codeine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with efavirenz.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Olopatadine.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Milnacipran.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with amoxapine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Levocetirizine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Propoxycaine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with nimodipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with amisulpride.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Pramocaine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with chlorothiazide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with sertraline.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with haloperidol.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Escitalopram.", "severity": 2}
{"drug1": "doxepin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Escitalopram.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with furazolidone.", "severity": 2}
{"drug1": "etizolam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with amitriptyline.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with ketoprofen.", "severity": 2}
{"drug1": "etizolam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Tolcapone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nicardipine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with floctafenine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with efavirenz.", "severity": 2}
{"drug1": "dopamine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with efavirenz.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Pomalidomide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Perospirone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with trazodone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Salsalate.", "severity": 2}
{"drug1": "codeine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "sotalol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "etodolac", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with nimesulide.", "severity": 2}
{"drug1": "pimozide", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Pizotifen.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with methscopolamine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "ketorolac", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with acemetacin.", "severity": 2}
{"drug1": "morphine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with terazosin.", "severity": 2}
{"drug1": "risperidone", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with diazepam.", "severity": 2}
{"drug1": "halothane", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with lisinopril.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with cyclopentolate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with levodopa.", "severity": 2}
{"drug1": "halothane", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with trimipramine.", "severity": 2}
{"drug1": "halothane", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nitroglycerin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with ketoprofen.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with ethotoin.", "severity": 2}
{"drug1": "propofol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Etomidate.", "severity": 2}
{"drug1": "propofol", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with bupivacaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with chlorprothixene.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with fludiazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Melatonin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with chloral hydrate.", "severity": 2}
{"drug1": "estazolam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with promethazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with clonazepam.", "severity": 2}
{"drug1": "felbamate", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Levomilnacipran.", "severity": 2}
{"drug1": "lisinopril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with penbutolol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with clomipramine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Eplerenone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with methazolamide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with equilin.", "severity": 2}
{"drug1": "tiapride", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with butalbital.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with chlorthalidone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with desipramine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with pancuronium.", "severity": 2}
{"drug1": "butabarbital", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with mesoridazine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with maprotiline.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "isradipine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with prazosin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with doxepin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Ramelteon.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "doxepin", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Bambuterol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with amcinonide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with tubocurarine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with zotepine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with MELPERONE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with oxymorphone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with manidipine.", "severity": 2}
{"drug1": "procaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "halothane", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with chlorprothixene.", "severity": 2}
{"drug1": "Trospium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "halothane", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ESMOLOL.", "severity": 2}
{"drug1": "dibucaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with clonazepam.", "severity": 2}
{"drug1": "dibucaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with promethazine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Perospirone.", "severity": 2}
{"drug1": "halothane", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with baclofen.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with atorvastatin.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "ethopropazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with ethopropazine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Melatonin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with HEROIN.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with orphenadrine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Canrenoic acid.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Asenapine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Milnacipran.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with citalopram.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with HEROIN.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with pravastatin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Etidronic acid.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "propranolol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Eplerenone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Nebivolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with chlorthalidone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with vigabatrin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Escitalopram.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Torasemide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Hexobarbital.", "severity": 2}
{"drug1": "estazolam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Agomelatine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Butethal.", "severity": 2}
{"drug1": "phenytoin", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Carbocisteine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with flunarizine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "selegiline", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Clevidipine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Mometasone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with chlorprothixene.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Levetiracetam.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Torasemide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Tolcapone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with levodopa.", "severity": 2}
{"drug1": "methylene blue", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with Clevidipine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with clonazepam.", "severity": 2}
{"drug1": "loratadine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with efavirenz.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with haloperidol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Lormetazepam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with enalapril.", "severity": 2}
{"drug1": "sulindac", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with triamcinolone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with manidipine.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with clomipramine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with bezafibrate.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with clozapine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Ketobemidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Pizotifen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with ethotoin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with indapamide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with prilocaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with dibucaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Perospirone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with leflunomide.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with levorphanol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Lurasidone.", "severity": 2}
{"drug1": "losartan", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with salicylamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with scopolamine.", "severity": 2}
{"drug1": "codeine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "codeine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with DEZOCINE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with nylidrin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Riociguat.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with suprofen.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with carbamazepine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with clomipramine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with topiramate.", "severity": 2}
{"drug1": "nadolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Aliskiren.", "severity": 2}
{"drug1": "risperidone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Difenoxin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with papaverine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "flumazenil", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumazenil is combined with olanzapine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Deferasirox.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with flunisolide.", "severity": 2}
{"drug1": "codeine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Levetiracetam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Fospropofol.", "severity": 2}
{"drug1": "benazepril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with tiapride.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Mometasone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "clozapine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Bretylium.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with nifedipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with GUANFACINE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "benazepril", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with nicardipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with papaverine.", "severity": 2}
{"drug1": "biperiden", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Butylscopolamine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with GUANFACINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Phenelzine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Aceprometazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with fosinopril.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with labetalol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with ESMOLOL.", "severity": 2}
{"drug1": "enflurane", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Tasimelteon.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with mesoridazine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with medrysone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with mefenamic acid.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with lovastatin.", "severity": 2}
{"drug1": "ramipril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with alclofenac.", "severity": 2}
{"drug1": "morphine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nalbuphine.", "severity": 2}
{"drug1": "codeine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with sevoflurane.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Difenoxin.", "severity": 2}
{"drug1": "triprolidine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with vigabatrin.", "severity": 2}
{"drug1": "codeine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chlorprothixene.", "severity": 2}
{"drug1": "morphine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Mephobarbital.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "metrizamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with metrizamide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Risedronic acid.", "severity": 2}
{"drug1": "benazepril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with oxaprozin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with perphenazine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with promethazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with levorphanol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with prazosin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Pizotifen.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nitroglycerin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with trimipramine.", "severity": 2}
{"drug1": "butamben", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with promethazine.", "severity": 2}
{"drug1": "butamben", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with clonazepam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with lisinopril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with VERAPAMIL.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Levetiracetam.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "selegiline", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Levomepromazine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Levalbuterol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "enalapril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with enalapril.", "severity": 2}
{"drug1": "selegiline", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Bambuterol.", "severity": 2}
{"drug1": "enalapril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with GUANFACINE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with antipyrine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with apraclonidine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with paramethasone.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Ramelteon.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with olanzapine.", "severity": 2}
{"drug1": "procaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "temazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with omeprazole.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Vardenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Vardenafil.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with maprotiline.", "severity": 2}
{"drug1": "linezolid", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Paliperidone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Butethal.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "meprobamate", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with amobarbital.", "severity": 2}
{"drug1": "midazolam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with apraclonidine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with lithium ion.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with butalbital.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Perospirone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with clonidine.", "severity": 2}
{"drug1": "quazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with prilocaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nimodipine.", "severity": 2}
{"drug1": "quazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with paroxetine.", "severity": 2}
{"drug1": "quazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with ethotoin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Lormetazepam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Drospirenone.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with manidipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with Demecarium.", "severity": 2}
{"drug1": "diflunisal", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with topiramate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Trilostane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Trilostane.", "severity": 2}
{"drug1": "methadone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Bretylium.", "severity": 2}
{"drug1": "prednisone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with atorvastatin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with etizolam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with vigabatrin.", "severity": 2}
{"drug1": "captopril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Sacubitril.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with duloxetine.", "severity": 2}
{"drug1": "reserpine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with benzocaine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with chloral hydrate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Propoxycaine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Pramocaine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Lornoxicam.", "severity": 2}
{"drug1": "pergolide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with propoxyphene.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with Calcipotriol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with HEROIN.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with papaverine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with fludiazepam.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nifedipine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Halazepam.", "severity": 2}
{"drug1": "promazine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with fexofenadine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Deferasirox.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with etizolam.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with oxybutynin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Estrone sulfate.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with promethazine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with halcinonide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with rasagiline.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with difluprednate.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Pefloxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with salicylic acid.", "severity": 2}
{"drug1": "halcinonide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "diazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with felbamate.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Lormetazepam.", "severity": 2}
{"drug1": "reserpine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Indacaterol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with flunarizine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Fluspirilene.", "severity": 2}
{"drug1": "Epirubicin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Epirubicin is combined with leflunomide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with methylprednisolone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Levomepromazine.", "severity": 2}
{"drug1": "budesonide", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with ambenonium.", "severity": 2}
{"drug1": "enalapril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with carprofen.", "severity": 2}
{"drug1": "reserpine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with butalbital.", "severity": 2}
{"drug1": "reserpine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with thiothixene.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Eplerenone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with methazolamide.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "clozapine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Mephobarbital.", "severity": 2}
{"drug1": "captopril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Eplerenone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with methazolamide.", "severity": 2}
{"drug1": "butenafine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with nicardipine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Halobetasol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with butorphanol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with trimipramine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Agomelatine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with Temsirolimus.", "severity": 2}
{"drug1": "tolmetin", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with antipyrine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with procaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Desloratadine.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with Levomilnacipran.", "severity": 2}
{"drug1": "equilin", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with fleroxacin.", "severity": 2}
{"drug1": "buspirone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Ciclesonide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with medrysone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Canagliflozin.", "severity": 2}
{"drug1": "morphine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Ketobemidone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "topiramate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with atenolol.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with tiagabine.", "severity": 2}
{"drug1": "clonidine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with indapamide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with terbutaline.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nitric oxide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with methazolamide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with carprofen.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Eplerenone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with doxepin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Levetiracetam.", "severity": 2}
{"drug1": "promethazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Milnacipran.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with nefazodone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with spironolactone.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with methadone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "labetalol", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with dobutamine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with furazolidone.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Phenelzine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with triflupromazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with oxycodone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with dantrolene.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with nifedipine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with celecoxib.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with quinapril.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with trazodone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with papaverine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with Echothiophate.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "linezolid", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with mesoridazine.", "severity": 2}
{"drug1": "linezolid", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with maprotiline.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with zonisamide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "loratadine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with levodopa.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with spironolactone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with norfloxacin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with tolterodine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with nalbuphine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Nebivolol.", "severity": 2}
{"drug1": "loratadine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with nortriptyline.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Trovafloxacin.", "severity": 2}
{"drug1": "loratadine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with amoxapine.", "severity": 2}
{"drug1": "felodipine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with carvedilol.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with primidone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "sulfadiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with sulfadiazine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Cevimeline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with nicotine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with mycophenolic acid.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with minoxidil.", "severity": 2}
{"drug1": "papaverine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with carvedilol.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with diazepam.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Iloperidone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with buspirone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "furazolidone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with oxycodone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Torasemide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with ALFENTANIL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with proparacaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with glyburide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Halazepam.", "severity": 2}
{"drug1": "methysergide", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with tiagabine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Pimecrolimus.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with tiagabine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with diclofenac.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with zonisamide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Mephobarbital.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ESMOLOL.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with triamcinolone.", "severity": 2}
{"drug1": "prazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with loratadine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with prilocaine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with imipramine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with diflorasone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Difenoxin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Conivaptan.", "severity": 2}
{"drug1": "trazodone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with METAXALONE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Droxicam.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with homoharringtonine.", "severity": 2}
{"drug1": "trazodone", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with sumatriptan.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with MELPERONE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with bumetanide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with azelastine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with quinapril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with vigabatrin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Aripiprazole.", "severity": 2}
{"drug1": "procaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with mirtazapine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "terconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with nicardipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with droperidol.", "severity": 2}
{"drug1": "aspirin", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with equilin.", "severity": 2}
{"drug1": "ethanol", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with rasagiline.", "severity": 2}
{"drug1": "levodopa", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Phenelzine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "thiopental", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Flibanserin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with felodipine.", "severity": 2}
{"drug1": "midazolam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with oxymorphone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with vinorelbine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Difenoxin.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Difenoxin.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with indomethacin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with sparfloxacin.", "severity": 2}
{"drug1": "thiopental", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with citalopram.", "severity": 2}
{"drug1": "azelastine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with zaltoprofen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Apremilast.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with deslanoside.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Masoprocol.", "severity": 2}
{"drug1": "diazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with quinapril.", "severity": 2}
{"drug1": "pancuronium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with meperidine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with chlorothiazide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with formoterol.", "severity": 2}
{"drug1": "cetirizine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with citalopram.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nadolol.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Riociguat.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Cyamemazine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with tubocurarine.", "severity": 2}
{"drug1": "methysergide", "drug2": "mifepristone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with mifepristone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Perospirone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with hydralazine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Loxoprofen.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Agomelatine.", "severity": 2}
{"drug1": "clozapine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with dantrolene.", "severity": 2}
{"drug1": "amifostine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with rasagiline.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Pomalidomide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Metipranolol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Melatonin.", "severity": 2}
{"drug1": "clozapine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "triazolam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with clomipramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with fludiazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Fencamfamin.", "severity": 2}
{"drug1": "zonisamide", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with levodopa.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gemfibrozil is combined with Ezetimibe.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with losartan.", "severity": 2}
{"drug1": "nystatin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with manidipine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with felodipine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with HEROIN.", "severity": 2}
{"drug1": "nystatin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with cilnidipine.", "severity": 2}
{"drug1": "nystatin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Benidipine.", "severity": 2}
{"drug1": "nystatin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Azelnidipine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Nebivolol.", "severity": 2}
{"drug1": "trazodone", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with bromocriptine.", "severity": 2}
{"drug1": "nystatin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Efonidipine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "cocaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with meclizine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ruxolitinib is combined with leflunomide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with topiramate.", "severity": 2}
{"drug1": "sulindac", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Asenapine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with enflurane.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Nitroprusside.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with methazolamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Eplerenone.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with Paricalcitol.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with nortriptyline.", "severity": 2}
{"drug1": "butorphanol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with amoxapine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with clozapine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Lorcaserin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with meperidine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with floctafenine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with amisulpride.", "severity": 2}
{"drug1": "imipramine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with atenolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with triflupromazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Retigabine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Levocetirizine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "valsartan", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with tolfenamic acid.", "severity": 2}
{"drug1": "lisinopril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with leflunomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with spironolactone.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with methadone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with fleroxacin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with memantine.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Alitretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with Alitretinoin.", "severity": 2}
{"drug1": "zotepine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Pipamperone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with benazepril.", "severity": 2}
{"drug1": "equilin", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with mefloquine.", "severity": 2}
{"drug1": "felodipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with Varenicline.", "severity": 2}
{"drug1": "enflurane", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Lormetazepam.", "severity": 2}
{"drug1": "triazolam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Propoxycaine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with tolfenamic acid.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Pramocaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with carisoprodol.", "severity": 2}
{"drug1": "amifostine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with apraclonidine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Isoflurophate.", "severity": 2}
{"drug1": "aspirin", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Mometasone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with fexofenadine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Efonidipine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with trifluoperazine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with chlorprothixene.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Benidipine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with cilnidipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with tizanidine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with furosemide.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with manidipine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with isoxsuprine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with baclofen.", "severity": 2}
{"drug1": "etodolac", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with methylprednisolone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with cilazapril.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Ethylmorphine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "DEXKETOPROFEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with DEXKETOPROFEN.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with fludrocortisone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Fluprednidene.", "severity": 2}
{"drug1": "diclofenac", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with fosinopril.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with flumethasone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with floctafenine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with mesalamine.", "severity": 2}
{"drug1": "formestane", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with enoxacin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Tolcapone.", "severity": 2}
{"drug1": "azelastine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with diflorasone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Agomelatine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with clonidine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with hydrocortisone.", "severity": 2}
{"drug1": "benazepril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with alclofenac.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Naftifine.", "severity": 2}
{"drug1": "azelastine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "codeine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Iloperidone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with ambenonium.", "severity": 2}
{"drug1": "ketamine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Asenapine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with tranylcypromine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with lithium ion.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with tetracaine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Vilanterol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with fexofenadine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Butethal.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with procarbazine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Echothiophate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with nadolol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with methylprednisolone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with terazosin.", "severity": 2}
{"drug1": "cocaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Halobetasol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with epirizole.", "severity": 2}
{"drug1": "naratriptan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with procarbazine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Tasimelteon.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with chlorzoxazone.", "severity": 2}
{"drug1": "prazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with MELPERONE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with zotepine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "valsartan", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with mecamylamine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Ketobemidone.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with dobutamine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with furazolidone.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Efonidipine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with dantrolene.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Benidipine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Azelnidipine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with cilnidipine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with galanthamine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with fenbufen.", "severity": 2}
{"drug1": "tizanidine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with lisinopril.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with fluocinonide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with mesoridazine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Pizotifen.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with maprotiline.", "severity": 2}
{"drug1": "zotepine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with triprolidine.", "severity": 2}
{"drug1": "zotepine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with methocarbamol.", "severity": 2}
{"drug1": "zotepine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with methylphenidate.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with desoximetasone.", "severity": 2}
{"drug1": "propantheline", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with DESFLURANE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with MELPERONE.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lansoprazole is combined with atorvastatin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with memantine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with medrysone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Metixene", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with buprenorphine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with MELPERONE.", "severity": 2}
{"drug1": "clonidine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Levocetirizine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with AMILORIDE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with dexamethasone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with felbamate.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Deferasirox.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PHENPROCOUMON is combined with Nintedanib.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Pipotiazine.", "severity": 2}
{"drug1": "benztropine", "drug2": "tropicamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with tropicamide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nicardipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with efavirenz.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Etidocaine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with propoxyphene.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with diflorasone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Butethal.", "severity": 2}
{"drug1": "gabapentin", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with thiothixene.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Hexobarbital.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Clodronic Acid.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with selegiline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with dobutamine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with felodipine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with chlormezanone.", "severity": 2}
{"drug1": "morniflumate", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with niflumic acid.", "severity": 2}
{"drug1": "ketamine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with oxprenolol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with phenytoin.", "severity": 2}
{"drug1": "losartan", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with nadolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "zaleplon", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with CYCLIZINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Decitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Decitabine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Tolcapone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Butethal", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "zotepine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Iloperidone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Retigabine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with atenolol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with bumetanide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Halobetasol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Escitalopram.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with quinapril.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with sparfloxacin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with lidocaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with clemastine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with venlafaxine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with zonisamide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with alclofenac.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Flibanserin.", "severity": 2}
{"drug1": "valsartan", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ondansetron.", "severity": 2}
{"drug1": "valsartan", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Metipranolol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "practolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when practolol is combined with Varenicline.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with bromocriptine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "halothane", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Riociguat.", "severity": 2}
{"drug1": "methadone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with methyclothiazide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "prazosin", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with hydralazine.", "severity": 2}
{"drug1": "baclofen", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with felbamate.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with zotepine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with MELPERONE.", "severity": 2}
{"drug1": "malathion", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when malathion is combined with Cevimeline.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with scopolamine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Etidronic acid.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with efavirenz.", "severity": 2}
{"drug1": "isoflurane", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with timolol.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with loxapine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Remoxipride.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with GUANFACINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Olopatadine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with methacholine.", "severity": 2}
{"drug1": "pergolide", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with nisoldipine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with benzyl alcohol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with reserpine.", "severity": 2}
{"drug1": "pergolide", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with alprazolam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Retigabine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "captopril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "methadone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with penbutolol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with barnidipine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with terazosin.", "severity": 2}
{"drug1": "quinapril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Naftifine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with doxorubicin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with phenytoin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Clobetasone.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Ketobemidone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with flunitrazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with triprolidine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with medrysone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with methocarbamol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with tiagabine.", "severity": 2}
{"drug1": "estazolam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with topiramate.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with rivastigmine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with haloperidol.", "severity": 2}
{"drug1": "halothane", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with tetracaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Riociguat.", "severity": 2}
{"drug1": "clomipramine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with isoproterenol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with physostigmine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Ramelteon.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Spirapril.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with oxymetazoline.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with sparfloxacin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with cilazapril.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with dipyridamole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with cilazapril.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Salsalate.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Sacubitril.", "severity": 2}
{"drug1": "glutethimide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with GUANFACINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with reserpine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "sotalol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Pizotifen.", "severity": 2}
{"drug1": "quetiapine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with trazodone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Benidipine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with trifluoperazine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with amoxapine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with nortriptyline.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with meperidine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with propoxyphene.", "severity": 2}
{"drug1": "dibucaine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with ondansetron.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with mesoridazine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with BISOPROLOL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with methoxyflurane.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with felodipine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with zonisamide.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with baclofen.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with zonisamide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with trandolapril.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with butorphanol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ondansetron.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Perospirone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with tiagabine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with cocaine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Remoxipride.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with loxapine.", "severity": 2}
{"drug1": "desipramine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with atorvastatin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with desipramine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with fludiazepam.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with brotizolam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with halothane.", "severity": 2}
{"drug1": "EDTA", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EDTA is combined with Deferasirox.", "severity": 2}
{"drug1": "brotizolam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with vigabatrin.", "severity": 2}
{"drug1": "brotizolam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with nortriptyline.", "severity": 2}
{"drug1": "brotizolam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with amoxapine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with benzocaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with halcinonide.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Demecarium is combined with Varenicline.", "severity": 2}
{"drug1": "etodolac", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with desoximetasone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with rasagiline.", "severity": 2}
{"drug1": "amoxapine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with PROCATEROL.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyamphetamine is combined with procarbazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with irbesartan.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Etidocaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Fencamfamin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with sulpiride.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with mecamylamine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with methoxyflurane.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with carisoprodol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Echothiophate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with dantrolene.", "severity": 2}
{"drug1": "ketorolac", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with niflumic acid.", "severity": 2}
{"drug1": "ketorolac", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with fludrocortisone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with norfloxacin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with methyclothiazide.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Sacubitril.", "severity": 2}
{"drug1": "pentamidine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with bepridil.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with enoxacin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Empagliflozin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Cyamemazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Icatibant.", "severity": 2}
{"drug1": "diltiazem", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with vigabatrin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with levodopa.", "severity": 2}
{"drug1": "flurazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "flurazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Retigabine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with tranylcypromine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with prazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with quazepam.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Tolcapone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with enoxacin.", "severity": 2}
{"drug1": "isradipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with atorvastatin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with loratadine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with betaxolol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with acetazolamide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with tranylcypromine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with citalopram.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with tetracaine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Eplerenone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with methazolamide.", "severity": 2}
{"drug1": "benazepril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with carisoprodol.", "severity": 2}
{"drug1": "Artemether", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with felodipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Salsalate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Difenoxin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with bromocriptine.", "severity": 2}
{"drug1": "temazepam", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with levorphanol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with flunarizine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "timolol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Eplerenone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with enflurane.", "severity": 2}
{"drug1": "betaxolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with quetiapine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with difluprednate.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with cinnarizine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with sertraline.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with NICORANDIL.", "severity": 2}
{"drug1": "oxazepam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with pimozide.", "severity": 2}
{"drug1": "meperidine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with nalbuphine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with bromazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Lurasidone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with furosemide.", "severity": 2}
{"drug1": "meperidine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with oxazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with bromazepam.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Retigabine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Difenoxin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with chlorpheniramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with penbutolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with lithium ion.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with flunitrazepam.", "severity": 2}
{"drug1": "apomorphine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Hexobarbital.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Eplerenone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Butethal.", "severity": 2}
{"drug1": "benazepril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with felodipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with methazolamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with perphenazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with indapamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with levorphanol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with indapamide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with cocaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with glutethimide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with proparacaine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Halazepam.", "severity": 2}
{"drug1": "enflurane", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with vigabatrin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with amobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with dantrolene.", "severity": 2}
{"drug1": "clozapine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with zonisamide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Butethal.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Escitalopram.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "clozapine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with mesalamine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with zonisamide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with lisinopril.", "severity": 2}
{"drug1": "tolmetin", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with flurandrenolide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with metolazone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with dibucaine.", "severity": 2}
{"drug1": "butamben", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with topiramate.", "severity": 2}
{"drug1": "oxycodone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with mesoridazine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with ROSOXACIN.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with tiagabine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with reserpine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with amoxapine.", "severity": 2}
{"drug1": "midodrine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with dopamine.", "severity": 2}
{"drug1": "carprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with thiamylal.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Potassium citrate.", "severity": 2}
{"drug1": "barnidipine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with cilnidipine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cetirizine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with imipramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Fluspirilene.", "severity": 2}
{"drug1": "cetirizine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with loratadine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with quetiapine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with clomipramine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with ethotoin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with clonazepam.", "severity": 2}
{"drug1": "alclometasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with galanthamine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with D-mannitol.", "severity": 2}
{"drug1": "temazepam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with diphenhydramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with isoproterenol.", "severity": 2}
{"drug1": "morphine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "morphine", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with nitrous oxide.", "severity": 2}
{"drug1": "CAPECITABINE", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CAPECITABINE is combined with leflunomide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with etodolac.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with hydrocortisone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Pentolinium.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with acebutolol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with ZILEUTON.", "severity": 2}
{"drug1": "clorazepate", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with minoxidil.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with fenoprofen.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with quetiapine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Thioproperazine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Ramelteon.", "severity": 2}
{"drug1": "tiagabine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with GUANFACINE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Lornoxicam.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "stavudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with stavudine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with tizanidine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "argatroban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with argatroban.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with scopolamine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Tapentadol.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Normethadone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with efavirenz.", "severity": 2}
{"drug1": "gabapentin", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with fludiazepam.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with promethazine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with chloral hydrate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "levodopa", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Pizotifen.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Propacetamol.", "severity": 2}
{"drug1": "tirofiban", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with mesalamine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with oxycodone.", "severity": 2}
{"drug1": "iodixanol", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when iodixanol is combined with metformin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with diflunisal.", "severity": 2}
{"drug1": "quinapril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Nepafenac.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with procaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Hexobarbital.", "severity": 2}
{"drug1": "butorphanol", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with lithium ion.", "severity": 2}
{"drug1": "butorphanol", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with amobarbital.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Butethal.", "severity": 2}
{"drug1": "zonisamide", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with duloxetine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with dibucaine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with fluoxetine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Empagliflozin.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Pizotifen.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Ramelteon.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "tiagabine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with felbamate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Vinflunine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Vinflunine.", "severity": 2}
{"drug1": "etizolam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Normethadone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with thiopental.", "severity": 2}
{"drug1": "imipramine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nitroglycerin.", "severity": 2}
{"drug1": "duloxetine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with sulpiride.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with methazolamide.", "severity": 2}
{"drug1": "imipramine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with vigabatrin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Lornoxicam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with doxepin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Masoprocol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Etoricoxib.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with valsartan.", "severity": 2}
{"drug1": "imipramine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with trimipramine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with vigabatrin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with SUFENTANIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Aceprometazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with MOLINDONE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with proparacaine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with D-mannitol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with trandolapril.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Halazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with oxprenolol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with niflumic acid.", "severity": 2}
{"drug1": "oxazepam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with buprenorphine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with flumethasone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with nefazodone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Asenapine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with doxepin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with methadone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with selegiline.", "severity": 2}
{"drug1": "docetaxel", "drug2": "4-Methoxyphenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with 4-Methoxyphenol.", "severity": 2}
{"drug1": "bepridil", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with quetiapine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with topiramate.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with procarbazine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Lercanidipine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "felodipine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with terazosin.", "severity": 2}
{"drug1": "thalidomide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with D-mannitol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with propofol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with maprotiline.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with cetirizine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with halothane.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with protriptyline.", "severity": 2}
{"drug1": "alclofenac", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with halcinonide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with difluprednate.", "severity": 2}
{"drug1": "bifonazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Canagliflozin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with amoxapine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with nortriptyline.", "severity": 2}
{"drug1": "prilocaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Fospropofol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Deferasirox.", "severity": 2}
{"drug1": "celecoxib", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with salicylic acid.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with bumetanide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with betamethasone.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with ropinirole.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Aliskiren.", "severity": 2}
{"drug1": "reserpine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with flunarizine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "timolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "aminophylline", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aminophylline is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with fluoxetine.", "severity": 2}
{"drug1": "thiopental", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with duloxetine.", "severity": 2}
{"drug1": "morphine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Nitroprusside.", "severity": 2}
{"drug1": "timolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Metipranolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with reserpine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with D-mannitol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with triprolidine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Normethadone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with methocarbamol.", "severity": 2}
{"drug1": "midazolam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "midazolam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with vigabatrin.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with Demecarium.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with tizanidine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Darunavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Darunavir.", "severity": 2}
{"drug1": "tropicamide", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with levorphanol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Aceprometazine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with pargyline.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Aceprometazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with cyclophosphamide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with sertraline.", "severity": 2}
{"drug1": "clemastine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with atorvastatin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Flupentixol.", "severity": 2}
{"drug1": "amsacrine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amsacrine is combined with leflunomide.", "severity": 2}
{"drug1": "butalbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with ethotoin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "butalbital", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with prilocaine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with etodolac.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with efavirenz.", "severity": 2}
{"drug1": "lidocaine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with dyclonine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with trandolapril.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with hydrocortisone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Deferasirox.", "severity": 2}
{"drug1": "midazolam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with decamethonium.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "6-Mercaptopurine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "midazolam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with bromazepam.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with butalbital.", "severity": 2}
{"drug1": "methysergide", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clindamycin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "trazodone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with felbamate.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with DEZOCINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with Pefloxacin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with sotalol.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Levetiracetam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with cinnarizine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "ambenonium", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambenonium is combined with acetylcholine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with bumetanide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Mometasone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "5-azacytidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with 5-azacytidine.", "severity": 2}
{"drug1": "butalbital", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with venlafaxine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Riociguat.", "severity": 2}
{"drug1": "butalbital", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with clemastine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with chlorothiazide.", "severity": 2}
{"drug1": "Articaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with clemastine.", "severity": 2}
{"drug1": "Articaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with venlafaxine.", "severity": 2}
{"drug1": "pimozide", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "methysergide", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with vinblastine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with ethotoin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with tranylcypromine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with prilocaine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with nefazodone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with cinoxacin.", "severity": 2}
{"drug1": "halothane", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with penbutolol.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with doxepin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with proparacaine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with niflumic acid.", "severity": 2}
{"drug1": "lorazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with clonidine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Carfilzomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Carfilzomib.", "severity": 2}
{"drug1": "proparacaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with METAXALONE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Olopatadine.", "severity": 2}
{"drug1": "promethazine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with clomipramine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "dapsone", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with phenobarbital.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with labetalol.", "severity": 2}
{"drug1": "propofol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with dantrolene.", "severity": 2}
{"drug1": "Articaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with ethotoin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with AMILORIDE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with zaltoprofen.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with doxazosin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Tolcapone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with betaxolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with amitriptyline.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with malathion.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with nitrous oxide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with chlormezanone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Perospirone.", "severity": 2}
{"drug1": "procaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "procaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with glutethimide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Etoricoxib.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Salsalate.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with periciazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Normethadone.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Boceprevir is combined with Temsirolimus.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Temsirolimus.", "severity": 2}
{"drug1": "prazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with duloxetine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Escitalopram.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with chloral hydrate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with flunarizine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with baclofen.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with oxycodone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Imatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Imatinib.", "severity": 2}
{"drug1": "morphine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Fencamfamin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Fospropofol.", "severity": 2}
{"drug1": "morphine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Olopatadine.", "severity": 2}
{"drug1": "amifostine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with tretinoin.", "severity": 2}
{"drug1": "amifostine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with tranylcypromine.", "severity": 2}
{"drug1": "amifostine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with isoflurane.", "severity": 2}
{"drug1": "lisinopril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with tenoxicam.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ketorolac.", "severity": 2}
{"drug1": "butalbital", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with desipramine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with nabumetone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with budesonide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Icatibant.", "severity": 2}
{"drug1": "isoflurane", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with brotizolam.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with ILOPROST.", "severity": 2}
{"drug1": "risperidone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with trifluoperazine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with mefloquine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with paroxetine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with MOLINDONE.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Amrinone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Perospirone.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Retigabine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with terbutaline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Lorcaserin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Flupentixol.", "severity": 2}
{"drug1": "metolazone", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with VERAPAMIL.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "trandolapril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with oxaprozin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Fencamfamin.", "severity": 2}
{"drug1": "imipramine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with sulpiride.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with digoxin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Perospirone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Lurasidone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with brotizolam.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Salsalate.", "severity": 2}
{"drug1": "azelastine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Normethadone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with nadolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with methadone.", "severity": 2}
{"drug1": "valsartan", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Butethal", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with amisulpride.", "severity": 2}
{"drug1": "valsartan", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with fenbufen.", "severity": 2}
{"drug1": "prazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with olanzapine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Butethal", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with HEROIN.", "severity": 2}
{"drug1": "pramipexole", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with sotalol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with omeprazole.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with tofisopam.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Sacubitril.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Levocetirizine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with rizatriptan.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with naratriptan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with methoxyflurane.", "severity": 2}
{"drug1": "isoflurane", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with isoxsuprine.", "severity": 2}
{"drug1": "ethanol", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with zopiclone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Butethal.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Hexobarbital.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with terbutaline.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with lithium ion.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Sitaxsentan.", "severity": 2}
{"drug1": "enalapril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with resveratrol.", "severity": 2}
{"drug1": "morphine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with meclizine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with butamben.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Desloratadine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Tasimelteon.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Halazepam.", "severity": 2}
{"drug1": "cocaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with mepivacaine.", "severity": 2}
{"drug1": "procaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with fluoxetine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Cyamemazine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Clobetasone.", "severity": 2}
{"drug1": "procaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with duloxetine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ifosfamide is combined with clozapine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Teriflunomide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with promethazine.", "severity": 2}
{"drug1": "enalapril", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with procaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with niflumic acid.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "triprolidine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with felbamate.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with decamethonium.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with methadone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Levocetirizine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with MELPERONE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with CLONIXIN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Canagliflozin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Loxoprofen.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Ziprasidone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with olanzapine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "epinephrine", "drug2": "methoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with methoxamine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Droxicam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with isoxsuprine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Ramelteon.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with fludrocortisone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with sulpiride.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Tasimelteon.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with chlorthalidone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with betamethasone.", "severity": 2}
{"drug1": "loxapine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "loxapine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Halazepam.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with physostigmine.", "severity": 2}
{"drug1": "loxapine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with proparacaine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "azelastine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with betamethasone.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Propacetamol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with thiopental.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with haloperidol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Pipamperone.", "severity": 2}
{"drug1": "trazodone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with GUANFACINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with ethosuximide.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "amantadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimethoprim is combined with amantadine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with doxorubicin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with felbamate.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Clobetasone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with etizolam.", "severity": 2}
{"drug1": "Naftifine", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with suprofen.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with nicardipine.", "severity": 2}
{"drug1": "codeine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with alclometasone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Desloratadine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Naftifine.", "severity": 2}
{"drug1": "propofol", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with mesoridazine.", "severity": 2}
{"drug1": "propofol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with maprotiline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with flunitrazepam.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with morphine.", "severity": 2}
{"drug1": "clozapine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Cis-mdp.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with D-mannitol.", "severity": 2}
{"drug1": "timolol", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with benazepril.", "severity": 2}
{"drug1": "enalapril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "dopamine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with nylidrin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Fluspirilene.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Retigabine.", "severity": 2}
{"drug1": "imipramine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with celiprolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Pizotifen.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with triamterene.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Desloratadine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Olopatadine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with eperisone.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Olsalazine.", "severity": 2}
{"drug1": "bepridil", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with dichlorphenamide.", "severity": 2}
{"drug1": "promazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with butamben.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Olopatadine.", "severity": 2}
{"drug1": "labetalol", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with isoproterenol.", "severity": 2}
{"drug1": "selegiline", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with quinapril.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "imipramine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Ramelteon.", "severity": 2}
{"drug1": "ropinirole", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with tolazoline.", "severity": 2}
{"drug1": "ketamine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with meclizine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with methadone.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with efavirenz.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with DESONIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with dichlorphenamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Loxoprofen.", "severity": 2}
{"drug1": "procaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "cabergoline", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with manidipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Butethal.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with amobarbital.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Lormetazepam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with enflurane.", "severity": 2}
{"drug1": "Amrinone", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with cetirizine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Escitalopram.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Almotriptan.", "severity": 2}
{"drug1": "Droxicam", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with fludrocortisone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with phenobarbital.", "severity": 2}
{"drug1": "chloroquine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with ethchlorvynol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Olaparib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Olaparib.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Palbociclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Palbociclib.", "severity": 2}
{"drug1": "benzocaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with felbamate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with chlormezanone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with xylometazoline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "biperiden", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with methscopolamine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Mometasone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with difluprednate.", "severity": 2}
{"drug1": "tretinoin", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with dichlorphenamide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with felodipine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Efonidipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ethosuximide.", "severity": 2}
{"drug1": "methazolamide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with ethosuximide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with triprolidine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with AMILORIDE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with cilnidipine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with MOLINDONE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with thiopental.", "severity": 2}
{"drug1": "chloroxine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with manidipine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with amcinonide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with prednisone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Salsalate.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rosuvastatin is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "valsartan", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with dibucaine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with levodopa.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Propoxycaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with carisoprodol.", "severity": 2}
{"drug1": "propofol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with triflupromazine.", "severity": 2}
{"drug1": "triazolam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with dipyridamole.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Zoledronic acid.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "chloroquine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with chlorthalidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "loxapine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with sotalol.", "severity": 2}
{"drug1": "temazepam", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with meperidine.", "severity": 2}
{"drug1": "temazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with loratadine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with brimonidine.", "severity": 2}
{"drug1": "valsartan", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with timolol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Nabilone.", "severity": 2}
{"drug1": "tropicamide", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with orphenadrine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "valsartan", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with irbesartan.", "severity": 2}
{"drug1": "ambenonium", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambenonium is combined with nicotine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "SIMEPREVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with morphine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Tolcapone.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with desipramine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with amitriptyline.", "severity": 2}
{"drug1": "buspirone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with chlormezanone.", "severity": 2}
{"drug1": "valsartan", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with mycophenolic acid.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with naratriptan.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with rizatriptan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with clomipramine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with enoxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with ibuprofen.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Ciclesonide.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Clevidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Asenapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with ethosuximide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with clemastine.", "severity": 2}
{"drug1": "codeine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with benzocaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Olmesartan.", "severity": 2}
{"drug1": "codeine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chlorthalidone.", "severity": 2}
{"drug1": "morniflumate", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with diclofenac.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with vigabatrin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Eprosartan.", "severity": 2}
{"drug1": "Etomidate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with dibucaine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with doxazosin.", "severity": 2}
{"drug1": "captopril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with leflunomide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with AMILORIDE.", "severity": 2}
{"drug1": "etizolam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with labetalol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with ambenonium.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with tizanidine.", "severity": 2}
{"drug1": "topiramate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "midazolam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with ethosuximide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with propoxyphene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "midazolam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with thiopental.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Pizotifen.", "severity": 2}
{"drug1": "clorazepate", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with cocaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with ondansetron.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Fluspirilene.", "severity": 2}
{"drug1": "propranolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with acetylcholine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Darunavir is combined with Abemaciclib.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with cyclothiazide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with ethotoin.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with oxycodone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with zonisamide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with etizolam.", "severity": 2}
{"drug1": "procaine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Halazepam.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "procaine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with proparacaine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with fenbufen.", "severity": 2}
{"drug1": "isoflurane", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with methyclothiazide.", "severity": 2}
{"drug1": "propofol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Etidocaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nisoldipine.", "severity": 2}
{"drug1": "biperiden", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with propoxyphene.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Pizotifen.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with edrophonium.", "severity": 2}
{"drug1": "propofol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with enalapril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with lithium ion.", "severity": 2}
{"drug1": "amisulpride", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with clonazepam.", "severity": 2}
{"drug1": "amisulpride", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with promethazine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Butethal.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with amobarbital.", "severity": 2}
{"drug1": "gemcitabine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gemcitabine is combined with clozapine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with imipramine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with pravastatin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "clozapine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with butalbital.", "severity": 2}
{"drug1": "gabapentin", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with felbamate.", "severity": 2}
{"drug1": "amiodarone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with methazolamide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with loratadine.", "severity": 2}
{"drug1": "triazolam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with methyclothiazide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with hydralazine.", "severity": 2}
{"drug1": "Camazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Camazepam is combined with olanzapine.", "severity": 2}
{"drug1": "prazosin", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with doxazosin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with D-mannitol.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with desipramine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "clonidine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "reserpine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Eplerenone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with isoflurane.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with carisoprodol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Masoprocol.", "severity": 2}
{"drug1": "reserpine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with etizolam.", "severity": 2}
{"drug1": "methysergide", "drug2": "Delavirdine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Delavirdine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with efavirenz.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with fluocinonide.", "severity": 2}
{"drug1": "quinapril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with tolmetin.", "severity": 2}
{"drug1": "atenolol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with lisinopril.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with fosinopril.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with tiapride.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Iloperidone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with homoharringtonine.", "severity": 2}
{"drug1": "methysergide", "drug2": "amprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with amprenavir.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ethotoin.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with butorphanol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with chlorprothixene.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with levodopa.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with proparacaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with butalbital.", "severity": 2}
{"drug1": "bromazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with paroxetine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Paliperidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Rosuvastatin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with chlormezanone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with nefazodone.", "severity": 2}
{"drug1": "argatroban", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "SAQUINAVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with phenobarbital.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with tolfenamic acid.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with isoflurane.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with moclobemide.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with benzocaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with ritodrine.", "severity": 2}
{"drug1": "morphine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Iloperidone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with vigabatrin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with tizanidine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Escitalopram.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with proparacaine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with clonidine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Nepafenac.", "severity": 2}
{"drug1": "estazolam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with ethotoin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with zotepine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Halazepam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Demecarium.", "severity": 2}
{"drug1": "Tramadol", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with gabapentin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with flunisolide.", "severity": 2}
{"drug1": "ramipril", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with timolol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with indapamide.", "severity": 2}
{"drug1": "enflurane", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Retigabine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Pipotiazine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Carbetocin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with lansoprazole.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Mometasone.", "severity": 2}
{"drug1": "methyldopa", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with dipyridamole.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with MOLINDONE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with protriptyline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with fluvastatin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with cetirizine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with zaleplon.", "severity": 2}
{"drug1": "pentazocine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with mepivacaine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Eplerenone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with methazolamide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with pentazocine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Pregabalin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with trazodone.", "severity": 2}
{"drug1": "meclizine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Desloratadine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with nitrendipine.", "severity": 2}
{"drug1": "halothane", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with tizanidine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with aspirin.", "severity": 2}
{"drug1": "halothane", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with furosemide.", "severity": 2}
{"drug1": "halothane", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with phentolamine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "butalbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with ethosuximide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Desloratadine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Pipotiazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "phenylephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with phenylephrine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with mepivacaine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "isradipine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with chlorothiazide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Ropivacaine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with morphine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with methyldopa.", "severity": 2}
{"drug1": "Melatonin", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with fexofenadine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Pramocaine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tramadol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with oxycodone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Pramocaine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Benidipine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Azelnidipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Nabilone.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Efonidipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with sotalol.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with manidipine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Olopatadine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with clonazepam.", "severity": 2}
{"drug1": "clozapine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "halothane", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with protriptyline.", "severity": 2}
{"drug1": "cocaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with fludiazepam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with halcinonide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with tetracaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Melatonin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with difluprednate.", "severity": 2}
{"drug1": "pimozide", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with tiapride.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with meclofenamic acid.", "severity": 2}
{"drug1": "quinapril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with epirizole.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Aceprometazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "methadone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Tasimelteon.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with dobutamine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Aripiprazole.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with chlorprothixene.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with Enalaprilat.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with azelastine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with cetirizine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Rotigotine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with protriptyline.", "severity": 2}
{"drug1": "clemastine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Difenoxin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Difenoxin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Agomelatine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "oxazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with trandolapril.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Milnacipran.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ketoprofen.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PENTAERYTHRITOL TETRANITRATE is combined with Deferasirox.", "severity": 2}
{"drug1": "desipramine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Pomalidomide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "amsacrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with amsacrine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with clonidine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with methylprednisolone.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with butorphanol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with acetazolamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with selegiline.", "severity": 2}
{"drug1": "topiramate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with clonazepam.", "severity": 2}
{"drug1": "carprofen", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with zaltoprofen.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with chloral hydrate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with irbesartan.", "severity": 2}
{"drug1": "thiothixene", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with halothane.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Apremilast.", "severity": 2}
{"drug1": "edrophonium", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when edrophonium is combined with acetylcholine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with thiamylal.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with mirtazapine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with methylprednisolone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with desipramine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with triflupromazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with resveratrol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with flunarizine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Fospropofol.", "severity": 2}
{"drug1": "tetracaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with dantrolene.", "severity": 2}
{"drug1": "memantine", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when memantine is combined with Cevimeline.", "severity": 2}
{"drug1": "budesonide", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with galanthamine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with Isoflurophate.", "severity": 2}
{"drug1": "mitomycin C", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mitomycin C is combined with clozapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "caffeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with caffeine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Hexobarbital.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Nepafenac.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Butethal.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with thiopental.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ciprofloxacin is combined with atorvastatin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with clonazepam.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with equilin.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with salicylic acid.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Pizotifen.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with MOXONIDINE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Perospirone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with trandolapril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with scopolamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with clenbuterol.", "severity": 2}
{"drug1": "methadone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Tolcapone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with cilazapril.", "severity": 2}
{"drug1": "furosemide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with papaverine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with galanthamine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Asenapine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with Isoflurophate.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with selegiline.", "severity": 2}
{"drug1": "DALFOPRISTIN", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DALFOPRISTIN is combined with atorvastatin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Indacaterol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Tolcapone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with norfloxacin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "dobutamine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with oxymetazoline.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Echothiophate.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with atenolol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with zaltoprofen.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Etidronic acid.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with amitriptyline.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Vandetanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Vandetanib.", "severity": 2}
{"drug1": "atenolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "thiothixene", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with clemastine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Paliperidone.", "severity": 2}
{"drug1": "carprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Sitaxsentan.", "severity": 2}
{"drug1": "methenamine", "drug2": "sulfacetamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methenamine is combined with sulfacetamide.", "severity": 2}
{"drug1": "nadolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with pilocarpine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with dantrolene.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Flibanserin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Eplerenone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with methazolamide.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with salicylamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ketoprofen.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with formestane.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with maprotiline.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Etidronic acid.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with losartan.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Lercanidipine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with flumethasone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with potassium ion.", "severity": 2}
{"drug1": "ethanol", "drug2": "Amfepramone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Amfepramone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with droxidopa.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "epirizole", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with methyclothiazide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with halothane.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Olsalazine.", "severity": 2}
{"drug1": "midazolam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with etizolam.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with trimipramine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with mesoridazine.", "severity": 2}
{"drug1": "levodopa", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with bupropion.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with fosinopril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with mianserin.", "severity": 2}
{"drug1": "promazine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with thiamylal.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Etidocaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with benzocaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with vigabatrin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with prilocaine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Perospirone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with isoflurane.", "severity": 2}
{"drug1": "THYMOL", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with nimodipine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with atorvastatin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with flunisolide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with maprotiline.", "severity": 2}
{"drug1": "methadone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with doxepin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with ouabain.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with sparfloxacin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with nortriptyline.", "severity": 2}
{"drug1": "prazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Tapentadol.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with captopril.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Iloperidone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with dexamethasone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with methyclothiazide.", "severity": 2}
{"drug1": "phentolamine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with thalidomide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with loteprednol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with tranylcypromine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with terbutaline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with tetracycline.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with paroxetine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with vinblastine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Iobenguane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Iobenguane.", "severity": 2}
{"drug1": "haloperidol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with scopolamine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with minoxidil.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Pizotifen.", "severity": 2}
{"drug1": "diazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with dibucaine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with fosinopril.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with methazolamide.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with levodopa.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Eplerenone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with flunitrazepam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Thioproperazine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "estriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with estriol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with carprofen.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with fleroxacin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "QUINESTROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with QUINESTROL.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Pramocaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with methylprednisolone.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with trimipramine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with tetracaine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Propoxycaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with isoniazid.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Agomelatine.", "severity": 2}
{"drug1": "topiramate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with flunarizine.", "severity": 2}
{"drug1": "oxymetholone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetholone is combined with atorvastatin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with meclizine.", "severity": 2}
{"drug1": "topiramate", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Sacubitril.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Etomidate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "methysergide", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nitric oxide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with atorvastatin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with scopolamine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Apremilast.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Ziprasidone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with oxymorphone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with decamethonium.", "severity": 2}
{"drug1": "trazodone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with nortriptyline.", "severity": 2}
{"drug1": "trazodone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with amoxapine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with venlafaxine.", "severity": 2}
{"drug1": "ketamine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with HEROIN.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with paramethasone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with medrysone.", "severity": 2}
{"drug1": "ethotoin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with paroxetine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Rotigotine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with triflupromazine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Tolcapone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with codeine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Asenapine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with ethotoin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with atorvastatin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with danazol.", "severity": 2}
{"drug1": "Propiverine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with methadone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Levomepromazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with pramipexole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with SERTINDOLE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with simvastatin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Alvimopan.", "severity": 2}
{"drug1": "promazine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Asenapine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Fospropofol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Metipranolol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with vigabatrin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Paliperidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with arsenic trioxide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "melphalan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalidixic acid is combined with melphalan.", "severity": 2}
{"drug1": "aspirin", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with flunisolide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with cetirizine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with propoxyphene.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with dyclonine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Lornoxicam.", "severity": 2}
{"drug1": "Torasemide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with deslanoside.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with mesoridazine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with MELPERONE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with zotepine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Nepafenac.", "severity": 2}
{"drug1": "loxapine", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with clorazepate.", "severity": 2}
{"drug1": "quinidine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Retigabine.", "severity": 2}
{"drug1": "loxapine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Aliskiren.", "severity": 2}
{"drug1": "loxapine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with efavirenz.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with acetazolamide.", "severity": 2}
{"drug1": "clidinium", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with vigabatrin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with Isoflurophate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with galanthamine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with carisoprodol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Icatibant.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "cisapride", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cisapride is combined with ethanol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with sertraline.", "severity": 2}
{"drug1": "quazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazamide is combined with Carbocisteine.", "severity": 2}
{"drug1": "etizolam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with sertraline.", "severity": 2}
{"drug1": "primidone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Levetiracetam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Hexobarbital.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with topiramate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Oxetacaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with olanzapine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with prednisone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with tiapride.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "ACENOCOUMAROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with Ephedrine.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with PROCATEROL.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with dipyridamole.", "severity": 2}
{"drug1": "trandolapril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with MOLINDONE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with DESONIDE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Aceprometazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with rasagiline.", "severity": 2}
{"drug1": "ethotoin", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with nefazodone.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with METAXALONE.", "severity": 2}
{"drug1": "morphine", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with potassium ion.", "severity": 2}
{"drug1": "loxapine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Butethal.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with thioridazine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclophosphamide is combined with leflunomide.", "severity": 2}
{"drug1": "morphine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with cilazapril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with sertraline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with selegiline.", "severity": 2}
{"drug1": "Naftifine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with flunarizine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with paramethasone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with DESONIDE.", "severity": 2}
{"drug1": "bifonazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with nisoldipine.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when actinomycin D is combined with leflunomide.", "severity": 2}
{"drug1": "propranolol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with papaverine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Fencamfamin.", "severity": 2}
{"drug1": "benztropine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with tolterodine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "procaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with carisoprodol.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with scopolamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with enalapril.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with phenmetrazine.", "severity": 2}
{"drug1": "propofol", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Torasemide.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with betamethasone.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with lovastatin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Risedronic acid.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "amprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with amprenavir.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with methazolamide.", "severity": 2}
{"drug1": "halothane", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Flibanserin.", "severity": 2}
{"drug1": "codeine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with nalbuphine.", "severity": 2}
{"drug1": "codeine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with oxazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Mephobarbital.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when disulfiram is combined with Carbocisteine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with carprofen.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with SUFENTANIL.", "severity": 2}
{"drug1": "reserpine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with nisoldipine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with pilocarpine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with fenoldopam.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with NICORANDIL.", "severity": 2}
{"drug1": "pancuronium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with morphine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with maprotiline.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with MELPERONE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with salicylamide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "amoxapine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Aripiprazole.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with chlorprothixene.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Mersalyl.", "severity": 2}
{"drug1": "butabarbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with triprolidine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with metoclopramide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with amcinonide.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with clidinium.", "severity": 2}
{"drug1": "Asenapine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with carisoprodol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Sacubitril.", "severity": 2}
{"drug1": "amiodarone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with spironolactone.", "severity": 2}
{"drug1": "buspirone", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with linezolid.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with zotepine.", "severity": 2}
{"drug1": "sertraline", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with atorvastatin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Ethylmorphine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Fencamfamin.", "severity": 2}
{"drug1": "meperidine", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with metoclopramide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ramipril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Masoprocol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with vigabatrin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with terbutaline.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Pregabalin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with zaltoprofen.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with salicylamide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with sertraline.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Pipamperone.", "severity": 2}
{"drug1": "triazolam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with tiagabine.", "severity": 2}
{"drug1": "triazolam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with cocaine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with nadolol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with dyclonine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with loteprednol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with propoxyphene.", "severity": 2}
{"drug1": "triazolam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with zonisamide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Clodronic Acid.", "severity": 2}
{"drug1": "reserpine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with glutethimide.", "severity": 2}
{"drug1": "equilin", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with etizolam.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with clopidogrel.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Pipamperone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with Echothiophate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Propoxycaine.", "severity": 2}
{"drug1": "equilin", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with donepezil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with baclofen.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Pipamperone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with norfloxacin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with efavirenz.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with clidinium.", "severity": 2}
{"drug1": "meclizine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with ethotoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "amifostine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Pomalidomide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Torasemide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with prednisone.", "severity": 2}
{"drug1": "meperidine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with pentazocine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with protriptyline.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Pipamperone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with triflupromazine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with cetirizine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "procyclidine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "prazosin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with isoxsuprine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Lurasidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with glutethimide.", "severity": 2}
{"drug1": "epirizole", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with alclometasone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with hydralazine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with codeine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with quinapril.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with bumetanide.", "severity": 2}
{"drug1": "baclofen", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with dantrolene.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with tetracaine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with chloral hydrate.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with pilocarpine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with fludiazepam.", "severity": 2}
{"drug1": "valsartan", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with fosinopril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with benzocaine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with vigabatrin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with Carbamylcholine.", "severity": 2}
{"drug1": "risperidone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with captopril.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Eprosartan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with imipramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with prazosin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with prochlorperazine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with paroxetine.", "severity": 2}
{"drug1": "risperidone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with quazepam.", "severity": 2}
{"drug1": "risperidone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with prazepam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Telmisartan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with apraclonidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with maprotiline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with mesoridazine.", "severity": 2}
{"drug1": "sertraline", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "methylene blue", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with isoproterenol.", "severity": 2}
{"drug1": "methadone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Oxetacaine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with carisoprodol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with methyldopa.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Deferasirox.", "severity": 2}
{"drug1": "methylene blue", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with olanzapine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with flunarizine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with phenytoin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with trimipramine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with chloroquine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Difenoxin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with sulindac.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with nalbuphine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "procaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with amisulpride.", "severity": 2}
{"drug1": "benzocaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with clonidine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Estrone sulfate.", "severity": 2}
{"drug1": "etodolac", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with diflunisal.", "severity": 2}
{"drug1": "temazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with felbamate.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with clozapine.", "severity": 2}
{"drug1": "risperidone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Desloratadine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Trospium", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with hyoscyamine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Butethal.", "severity": 2}
{"drug1": "risperidone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with baclofen.", "severity": 2}
{"drug1": "clorazepate", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with lithium ion.", "severity": 2}
{"drug1": "amisulpride", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with tiagabine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with tizanidine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with nifedipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with glutethimide.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with papaverine.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lenalidomide is combined with clozapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with levodopa.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Ketobemidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with brotizolam.", "severity": 2}
{"drug1": "Normethadone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with methyclothiazide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Difenoxin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with gabapentin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with prazosin.", "severity": 2}
{"drug1": "enalapril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with SERATRODAST.", "severity": 2}
{"drug1": "doxepin", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with captopril.", "severity": 2}
{"drug1": "trandolapril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with celecoxib.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Lanreotide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Lanreotide.", "severity": 2}
{"drug1": "captopril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "nystatin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with pimozide.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with sertraline.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with salicylamide.", "severity": 2}
{"drug1": "loxapine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Iloperidone.", "severity": 2}
{"drug1": "isradipine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with nisoldipine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with clomipramine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with fluoxetine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with terbutaline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with MELPERONE.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with duloxetine.", "severity": 2}
{"drug1": "felbamate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Ramelteon.", "severity": 2}
{"drug1": "moclobemide", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with HYDROCODONE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with hydromorphone.", "severity": 2}
{"drug1": "clonidine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Aceprometazine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with perphenazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with nortriptyline.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with chlorthalidone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "pergolide", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Ezetimibe.", "severity": 2}
{"drug1": "pergolide", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with azelastine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Clevidipine.", "severity": 2}
{"drug1": "pergolide", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with acetazolamide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with felbamate.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Escitalopram.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with ramipril.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with moclobemide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Pramocaine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with clidinium.", "severity": 2}
{"drug1": "linezolid", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Aripiprazole.", "severity": 2}
{"drug1": "linezolid", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with chlorprothixene.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Aliskiren.", "severity": 2}
{"drug1": "doxazosin", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with chlorothiazide.", "severity": 2}
{"drug1": "linezolid", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with metoclopramide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Frovatriptan.", "severity": 2}
{"drug1": "clonidine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with dantrolene.", "severity": 2}
{"drug1": "pentazocine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with HEROIN.", "severity": 2}
{"drug1": "risperidone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with felbamate.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with clidinium.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "oxazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with prilocaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Salsalate.", "severity": 2}
{"drug1": "midazolam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with felbamate.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "citalopram", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Almotriptan.", "severity": 2}
{"drug1": "cerulenin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "thiothixene", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with clonidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with DEZOCINE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Salsalate.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with zonisamide.", "severity": 2}
{"drug1": "triazolam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with thiothixene.", "severity": 2}
{"drug1": "ramipril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with zaltoprofen.", "severity": 2}
{"drug1": "isradipine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Olmesartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with SERATRODAST.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with triflupromazine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with tiagabine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with tiapride.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with nimesulide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with etizolam.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with Mirabegron.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Asenapine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Tolvaptan.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "clozapine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with methocarbamol.", "severity": 2}
{"drug1": "citalopram", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Cyamemazine.", "severity": 2}
{"drug1": "clozapine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with spironolactone.", "severity": 2}
{"drug1": "clozapine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with triprolidine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Sorafenib.", "severity": 2}
{"drug1": "pergolide", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with progesterone.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "tolmetin", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with epirizole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Retigabine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with buprenorphine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Pentolinium.", "severity": 2}
{"drug1": "estazolam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with ketamine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Normethadone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Alvimopan.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Aceprometazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with methyclothiazide.", "severity": 2}
{"drug1": "quazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Retigabine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with homoharringtonine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "etodolac", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Flibanserin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Cis-mdp.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with trimipramine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Paliperidone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with fluocinonide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Phenelzine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with hydralazine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Iloperidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with clozapine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with dicyclomine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Clevidipine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "ondansetron", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with chlormezanone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with desipramine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with baclofen.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with nalidixic acid.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Iloperidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with etoposide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with sparfloxacin.", "severity": 2}
{"drug1": "triazolam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with clonidine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with carvedilol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Retigabine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with sumatriptan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with terbutaline.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with propantheline.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with mepivacaine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cimetidine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Desloratadine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with desipramine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with oxprenolol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Bretylium.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with donepezil.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with mecamylamine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with hydromorphone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with tizanidine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with furazolidone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Telmisartan.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with methyldopa.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with dexamethasone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with captopril.", "severity": 2}
{"drug1": "buspirone", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with diazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Lormetazepam.", "severity": 2}
{"drug1": "reserpine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with clonidine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with dantrolene.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with clidinium.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with fenoprofen.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with sulpiride.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Pomalidomide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Etoricoxib.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "lamivudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with lamivudine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with felbamate.", "severity": 2}
{"drug1": "buspirone", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with oxymorphone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with topiramate.", "severity": 2}
{"drug1": "buspirone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with zopiclone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with benzocaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with hydromorphone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with mecamylamine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "spironolactone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with hydralazine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Masoprocol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with clomipramine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with dipyridamole.", "severity": 2}
{"drug1": "clozapine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Asenapine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with loratadine.", "severity": 2}
{"drug1": "prazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with clonazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with promethazine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with atenolol.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "methysergide", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "methadone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with fexofenadine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with quetiapine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with nimesulide.", "severity": 2}
{"drug1": "methadone", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with rizatriptan.", "severity": 2}
{"drug1": "methysergide", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Rosuvastatin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with apraclonidine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Tadalafil.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with ethotoin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with tranylcypromine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "tetracaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with methyldopa.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with triflupromazine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with nitroglycerin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with chlorprothixene.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with metoclopramide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Perospirone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with carisoprodol.", "severity": 2}
{"drug1": "diazepam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with pimozide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with tubocurarine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Clevidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with tizanidine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with atorvastatin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Salbutamol.", "severity": 2}
{"drug1": "thiopental", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with scopolamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with isoetharine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with oxymorphone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with minoxidil.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Metixene.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with Temsirolimus.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Halobetasol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "meperidine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "buspirone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "imipramine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with rizatriptan.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "clorazepate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with GUANFACINE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with penbutolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with propoxyphene.", "severity": 2}
{"drug1": "morphine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with baclofen.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with dyclonine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with doxepin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with propoxyphene.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Lormetazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Empagliflozin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with fosinopril.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with flurandrenolide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Ticagrelor.", "severity": 2}
{"drug1": "HEROIN", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with GUANFACINE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with sevoflurane.", "severity": 2}
{"drug1": "Spirapril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with tolmetin.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "morphine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with prazepam.", "severity": 2}
{"drug1": "HEROIN", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with MELPERONE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with zotepine.", "severity": 2}
{"drug1": "morphine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "morphine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with oxprenolol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Ketobemidone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with flunarizine.", "severity": 2}
{"drug1": "ethanol", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with methylene blue.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Cis-mdp.", "severity": 2}
{"drug1": "butenafine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with flunarizine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with metoclopramide.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with isoxsuprine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Metipranolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with flunarizine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Oxetacaine.", "severity": 2}
{"drug1": "quazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with thiopental.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with norfloxacin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Naftifine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Echothiophate.", "severity": 2}
{"drug1": "gabapentin", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with clidinium.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with AMILORIDE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with moclobemide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Clobetasone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with butamben.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with periciazine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with terbutaline.", "severity": 2}
{"drug1": "loxapine", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with prochlorperazine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Apremilast.", "severity": 2}
{"drug1": "linezolid", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with doxazosin.", "severity": 2}
{"drug1": "amifostine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Pipamperone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Tolcapone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with amitriptyline.", "severity": 2}
{"drug1": "gabapentin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with paroxetine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Propiverine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Pipotiazine.", "severity": 2}
{"drug1": "thiopental", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Tolcapone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with amitriptyline.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with mesalamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Olopatadine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Alvimopan.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with fenoprofen.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Milnacipran.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Bortezomib.", "severity": 2}
{"drug1": "butorphanol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with vigabatrin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with pyridostigmine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with tolterodine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "lisinopril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with GUANFACINE.", "severity": 2}
{"drug1": "furosemide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with ouabain.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Icatibant.", "severity": 2}
{"drug1": "tolmetin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Mersalyl.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with quetiapine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with betaxolol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ibudilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with ibudilast.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with epirizole.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with prazosin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with doxepin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Remoxipride.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Propoxycaine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Aceprometazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with perphenazine.", "severity": 2}
{"drug1": "estrone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with tubocurarine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with bromocriptine.", "severity": 2}
{"drug1": "risperidone", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with oxymorphone.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with benazepril.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "simvastatin", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when simvastatin is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "butorphanol", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with oxymorphone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Iloperidone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Clofarabine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "budesonide", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with sparfloxacin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with fludiazepam.", "severity": 2}
{"drug1": "epinephrine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with dobutamine.", "severity": 2}
{"drug1": "carprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with diflorasone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Cariprazine.", "severity": 2}
{"drug1": "triamterene", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with terazosin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with cinoxacin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with decamethonium.", "severity": 2}
{"drug1": "resveratrol", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with salicylic acid.", "severity": 2}
{"drug1": "imipramine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with promethazine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "imipramine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with isoproterenol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "imipramine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with budesonide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with brotizolam.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "clonidine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with chlorothiazide.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Fencamfamin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with ethotoin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with oxybutynin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Etidocaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with methyldopa.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nitrazepam.", "severity": 2}
{"drug1": "clonidine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "reserpine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with apraclonidine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with sertraline.", "severity": 2}
{"drug1": "reserpine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Telmisartan.", "severity": 2}
{"drug1": "reserpine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with mepivacaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with zaleplon.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with clomipramine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with oxaprozin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Ketobemidone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with fludrocortisone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Lurasidone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with topiramate.", "severity": 2}
{"drug1": "methenamine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methenamine is combined with sulpiride.", "severity": 2}
{"drug1": "lorazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with etizolam.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with estrone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Lurasidone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with clomipramine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with difluprednate.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with halcinonide.", "severity": 2}
{"drug1": "ATOVAQUONE", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATOVAQUONE is combined with dapsone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with amoxapine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with triamterene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with meclizine.", "severity": 2}
{"drug1": "clonidine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with bumetanide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with butalbital.", "severity": 2}
{"drug1": "Naftifine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with salicylic acid.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Mometasone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Propoxycaine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Torasemide.", "severity": 2}
{"drug1": "pimozide", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with MELPERONE.", "severity": 2}
{"drug1": "pimozide", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with zotepine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with phenobarbital.", "severity": 2}
{"drug1": "Naftifine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with aspirin.", "severity": 2}
{"drug1": "clofazimine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clofazimine is combined with atorvastatin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with DEZOCINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Lurasidone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with terazosin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nelfinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nelfinavir.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "indinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with indinavir.", "severity": 2}
{"drug1": "haloprogin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "cocaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Cariprazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with fenbufen.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Cariprazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "methadone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with DEZOCINE.", "severity": 2}
{"drug1": "codeine", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with potassium ion.", "severity": 2}
{"drug1": "Naftifine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with leflunomide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with chlorprothixene.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "quinidine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with pentazocine.", "severity": 2}
{"drug1": "dobutamine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with flumethasone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with CARTEOLOL.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with clidinium.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with metolazone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with buspirone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with fluoxetine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with chlormezanone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with hydralazine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with tiapride.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Apixaban.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with PAMABROM.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Nitroprusside.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Etomidate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with morphine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Asenapine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with azelastine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nitrendipine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Pomalidomide.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with cinnarizine.", "severity": 2}
{"drug1": "prazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with felbamate.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Canagliflozin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with butalbital.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with CLONIXIN.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with levodopa.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with sevoflurane.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Droxicam.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "sotalol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Empagliflozin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with VERAPAMIL.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Salsalate.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with atorvastatin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with flunitrazepam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with terazosin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with glutethimide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Methadyl acetate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with loratadine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with lithium ion.", "severity": 2}
{"drug1": "aspirin", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with diflorasone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Ramelteon.", "severity": 2}
{"drug1": "Asenapine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "sulindac", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with epirizole.", "severity": 2}
{"drug1": "flurazepam", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with propofol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with mianserin.", "severity": 2}
{"drug1": "quinapril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with fenbufen.", "severity": 2}
{"drug1": "prilocaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with clonidine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Tasimelteon.", "severity": 2}
{"drug1": "Halazepam", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with nefazodone.", "severity": 2}
{"drug1": "sulindac", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Aceclofenac.", "severity": 2}
{"drug1": "floctafenine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with salicylic acid.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with medrysone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with dipyridamole.", "severity": 2}
{"drug1": "benztropine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with doxepin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with meclofenamic acid.", "severity": 2}
{"drug1": "sulindac", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with SERATRODAST.", "severity": 2}
{"drug1": "zaleplon", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with proparacaine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with papaverine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with nifedipine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Halazepam.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Pizotifen.", "severity": 2}
{"drug1": "quinapril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with penbutolol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with brotizolam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Metipranolol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with estazolam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with dantrolene.", "severity": 2}
{"drug1": "ketamine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with metoclopramide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Escitalopram.", "severity": 2}
{"drug1": "felbamate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with dantrolene.", "severity": 2}
{"drug1": "prilocaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "propantheline", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with mecamylamine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with amcinonide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with chlormezanone.", "severity": 2}
{"drug1": "propantheline", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with pentazocine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Canagliflozin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Tasimelteon.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Pizotifen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with CYCLIZINE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Escitalopram.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with hydrocortisone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Ramelteon.", "severity": 2}
{"drug1": "cilazapril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with mefenamic acid.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with NAPROXEN.", "severity": 2}
{"drug1": "fenbufen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "halothane", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Articaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with zonisamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with desipramine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with thiamylal.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with GUANFACINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with glyburide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with halothane.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "triazolam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Hexobarbital.", "severity": 2}
{"drug1": "triazolam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with lithium ion.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with metyrapone.", "severity": 2}
{"drug1": "quinapril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with terazosin.", "severity": 2}
{"drug1": "papaverine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Nebivolol.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Pipotiazine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rifampicin is combined with clopidogrel.", "severity": 2}
{"drug1": "levorphanol", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with alprazolam.", "severity": 2}
{"drug1": "bepridil", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with tizanidine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with codeine.", "severity": 2}
{"drug1": "bepridil", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with furosemide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with atorvastatin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "meclizine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Retigabine.", "severity": 2}
{"drug1": "metolazone", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with loxapine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with bepridil.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with nitrazepam.", "severity": 2}
{"drug1": "dyclonine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with baclofen.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with levodopa.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with polythiazide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Nebivolol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Ramelteon.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "metolazone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with quetiapine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with flurandrenolide.", "severity": 2}
{"drug1": "labetalol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with sulindac.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with tolazoline.", "severity": 2}
{"drug1": "ropinirole", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with selegiline.", "severity": 2}
{"drug1": "ethanol", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with metformin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with chloroquine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with enoxacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Ciclesonide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Zoledronic acid.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Eprosartan.", "severity": 2}
{"drug1": "lidocaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "selegiline", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with amisulpride.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Tapentadol.", "severity": 2}
{"drug1": "alclofenac", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with zotepine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Dothiepin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with felbamate.", "severity": 2}
{"drug1": "estazolam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with doxepin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with estrone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with flunarizine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "clidinium", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with felbamate.", "severity": 2}
{"drug1": "dyclonine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with oxprenolol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "phentolamine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with ESMOLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with HEROIN.", "severity": 2}
{"drug1": "cocaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with topiramate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with resveratrol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Canagliflozin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with desoximetasone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with maprotiline.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "warfarin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with warfarin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with loratadine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with loratadine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Torasemide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with rasagiline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with imipramine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with imipramine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with tetracaine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with prednisone.", "severity": 2}
{"drug1": "dobutamine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with quinidine.", "severity": 2}
{"drug1": "quazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with AMILORIDE.", "severity": 2}
{"drug1": "halothane", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Escitalopram.", "severity": 2}
{"drug1": "halothane", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with CYCLIZINE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with doxazosin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with nortriptyline.", "severity": 2}
{"drug1": "Butethal", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with fludiazepam.", "severity": 2}
{"drug1": "apomorphine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with terazosin.", "severity": 2}
{"drug1": "Butethal", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with chloral hydrate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "Normethadone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with indapamide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with amitriptyline.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Tolcapone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with decamethonium.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Loxoprofen.", "severity": 2}
{"drug1": "sotalol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Eplerenone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Difenoxin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with SERTINDOLE.", "severity": 2}
{"drug1": "promazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with methylprednisolone.", "severity": 2}
{"drug1": "benztropine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Ketobemidone.", "severity": 2}
{"drug1": "buspirone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with tizanidine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "midazolam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Apremilast.", "severity": 2}
{"drug1": "enflurane", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Perospirone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with tolazoline.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Cariprazine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with sevoflurane.", "severity": 2}
{"drug1": "indapamide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with bumetanide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with chlorthalidone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with nifedipine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with nimesulide.", "severity": 2}
{"drug1": "indapamide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with quinapril.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with trimipramine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Deferasirox.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Clevidipine.", "severity": 2}
{"drug1": "pimozide", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with estazolam.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Phenelzine.", "severity": 2}
{"drug1": "CAPECITABINE", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CAPECITABINE is combined with clozapine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Clevidipine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with dexamethasone.", "severity": 2}
{"drug1": "pimozide", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with dantrolene.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with polythiazide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with bumetanide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Olopatadine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Aripiprazole.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with amisulpride.", "severity": 2}
{"drug1": "cetirizine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with dantrolene.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with doxepin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with bumetanide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with chlorothiazide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with dantrolene.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with primidone.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with nisoldipine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with edrophonium.", "severity": 2}
{"drug1": "meperidine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with AMILORIDE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with baclofen.", "severity": 2}
{"drug1": "methylene blue", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with loxapine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Remoxipride.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfasalazine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with alprazolam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Eszopiclone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Olopatadine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with duloxetine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Ramelteon.", "severity": 2}
{"drug1": "quetiapine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with HEROIN.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with efavirenz.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with lithium ion.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Cis-mdp.", "severity": 2}
{"drug1": "bromazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with doxepin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Mephobarbital.", "severity": 2}
{"drug1": "clorazepate", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with SUFENTANIL.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Efonidipine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with clomipramine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with oxaprozin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with sertraline.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with clidinium.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with trifluoperazine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with flurandrenolide.", "severity": 2}
{"drug1": "tirofiban", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with Olsalazine.", "severity": 2}
{"drug1": "Trospium", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with mecamylamine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Pizotifen.", "severity": 2}
{"drug1": "Trospium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with pentazocine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ifosfamide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with Mirabegron.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Frovatriptan.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with clonidine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Clevidipine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with zonisamide.", "severity": 2}
{"drug1": "clozapine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nitrendipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with papaverine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with nifedipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Nebivolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with diazoxide.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Lornoxicam.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with papaverine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with nifedipine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with methyclothiazide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "cabergoline", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with selegiline.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "alclofenac", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with prednisone.", "severity": 2}
{"drug1": "procaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "sertraline", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with reserpine.", "severity": 2}
{"drug1": "labetalol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with captopril.", "severity": 2}
{"drug1": "haloprogin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with diltiazem.", "severity": 2}
{"drug1": "zaleplon", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with fluoxetine.", "severity": 2}
{"drug1": "morphine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Telmisartan.", "severity": 2}
{"drug1": "morphine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Desloratadine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Milnacipran.", "severity": 2}
{"drug1": "diazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "morphine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with zaleplon.", "severity": 2}
{"drug1": "morphine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with methyldopa.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with mesalamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with cyclothiazide.", "severity": 2}
{"drug1": "methazolamide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with captopril.", "severity": 2}
{"drug1": "methazolamide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with acebutolol.", "severity": 2}
{"drug1": "halcinonide", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with fleroxacin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with mesoridazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with fexofenadine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with thiopental.", "severity": 2}
{"drug1": "butamben", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with doxepin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Vilazodone.", "severity": 2}
{"drug1": "haloprogin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with nimodipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Avanafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Udenafil is combined with Avanafil.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with propofol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with MELPERONE.", "severity": 2}
{"drug1": "butamben", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with nefazodone.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with betamethasone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Palbociclib is combined with leflunomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Ruxolitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Ruxolitinib.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with tranylcypromine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Enalaprilat.", "severity": 2}
{"drug1": "sulpiride", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with prilocaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with brotizolam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Cabozantinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Cabozantinib.", "severity": 2}
{"drug1": "sulpiride", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with ethotoin.", "severity": 2}
{"drug1": "atenolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with quetiapine.", "severity": 2}
{"drug1": "temazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with quetiapine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with glutethimide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with ibuprofen.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Aceprometazine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Methadyl acetate.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Propacetamol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with isradipine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with oxybutynin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Eribulin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Eribulin.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with paroxetine.", "severity": 2}
{"drug1": "terazosin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with cilazapril.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with nifedipine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Aceprometazine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Asenapine.", "severity": 2}
{"drug1": "quazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with trazodone.", "severity": 2}
{"drug1": "suprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with diflorasone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with clidinium.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with flumethasone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "methadone", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with benzocaine.", "severity": 2}
{"drug1": "methadone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with clidinium.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with meclizine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with trazodone.", "severity": 2}
{"drug1": "pergolide", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with dexamethasone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Lormetazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with oxymorphone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with ethotoin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with amisulpride.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with bromazepam.", "severity": 2}
{"drug1": "furosemide", "drug2": "allopurinol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with allopurinol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "etizolam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with tiagabine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "codeine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Levetiracetam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with oxycodone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with fludrocortisone.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with triprolidine.", "severity": 2}
{"drug1": "codeine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with meclizine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Desloratadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Lurasidone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with NAPROXEN.", "severity": 2}
{"drug1": "thiopental", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with mepivacaine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with oxycodone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with formestane.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with buspirone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Butethal.", "severity": 2}
{"drug1": "midazolam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Olopatadine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with lithium ion.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Hexobarbital.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Perospirone.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with tubocurarine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Ramelteon.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with propoxyphene.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with GUANFACINE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with oxaprozin.", "severity": 2}
{"drug1": "triazolam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with trazodone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Pipamperone.", "severity": 2}
{"drug1": "midazolam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with ethotoin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with tetracaine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with edrophonium.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Clevidipine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with diflorasone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with loratadine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with niflumic acid.", "severity": 2}
{"drug1": "halothane", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with felbamate.", "severity": 2}
{"drug1": "papaverine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with promethazine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with clonazepam.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with diltiazem.", "severity": 2}
{"drug1": "reserpine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "risperidone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Lormetazepam.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with flumethasone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Aliskiren.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with chlorthalidone.", "severity": 2}
{"drug1": "triazolam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with fexofenadine.", "severity": 2}
{"drug1": "biperiden", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with vigabatrin.", "severity": 2}
{"drug1": "captopril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Apremilast.", "severity": 2}
{"drug1": "doxazosin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with isoxsuprine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with loteprednol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with rasagiline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with polythiazide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Fluspirilene.", "severity": 2}
{"drug1": "difluprednate", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with cinoxacin.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with tetracaine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with nitric oxide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with ranitidine.", "severity": 2}
{"drug1": "methysergide", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with simvastatin.", "severity": 2}
{"drug1": "methysergide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with propoxyphene.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with baclofen.", "severity": 2}
{"drug1": "thioridazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with zonisamide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with ethchlorvynol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with topiramate.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with periciazine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with cetirizine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with protriptyline.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with ambroxol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with indapamide.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Naloxegol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with loratadine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with metoprolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with rasagiline.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with imipramine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "imipramine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with benzyl alcohol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with metolazone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ramipril", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with CARTEOLOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Caspofungin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with Calcipotriol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with edrophonium.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with mesoridazine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Lercanidipine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Ciclesonide.", "severity": 2}
{"drug1": "prednisone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with rivastigmine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with haloperidol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with nortriptyline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Icatibant.", "severity": 2}
{"drug1": "barnidipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with simvastatin.", "severity": 2}
{"drug1": "morphine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chlormezanone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with tetracaine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with isoxsuprine.", "severity": 2}
{"drug1": "felodipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with atorvastatin.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with loratadine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with imipramine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Fluspirilene.", "severity": 2}
{"drug1": "morphine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "flurazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with clomipramine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with nifedipine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with epoprostenol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with isocarboxazid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with bepridil.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with methyldopa.", "severity": 2}
{"drug1": "methysergide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nifedipine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with amoxapine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Butylscopolamine.", "severity": 2}
{"drug1": "methysergide", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with miconazole.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Empagliflozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with DESONIDE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with quetiapine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with isoetharine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with CARTEOLOL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with SUFENTANIL.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with ketamine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Sunitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Sunitinib.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with imipramine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with methazolamide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Eplerenone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Lormetazepam.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Ethylmorphine.", "severity": 2}
{"drug1": "pergolide", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Fencamfamin.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with manidipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "budesonide", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with physostigmine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with ILOPROST.", "severity": 2}
{"drug1": "budesonide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with rivastigmine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "difluprednate", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with edrophonium.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Difenoxin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with astemizole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with rasagiline.", "severity": 2}
{"drug1": "pentazocine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with amitriptyline.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with venlafaxine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with timolol.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with haloperidol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with tiapride.", "severity": 2}
{"drug1": "estazolam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with levodopa.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with sulpiride.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Fluspirilene.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with barnidipine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Pomalidomide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Zoledronic acid.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Nitroprusside.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Tolcapone.", "severity": 2}
{"drug1": "butamben", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with meclizine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Pomalidomide.", "severity": 2}
{"drug1": "morphine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with enflurane.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with ibuprofen.", "severity": 2}
{"drug1": "tiapride", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with trimipramine.", "severity": 2}
{"drug1": "zotepine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with fexofenadine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with vincristine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with chloral hydrate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with fludiazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Pregabalin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with methylphenidate.", "severity": 2}
{"drug1": "enalapril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with indomethacin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "EDTA", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with EDTA.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with dipyridamole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Pipotiazine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with azelastine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Propiverine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Tramadol.", "severity": 2}
{"drug1": "amifostine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Eszopiclone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Ketobemidone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with alprazolam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Clevidipine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with loxapine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Remoxipride.", "severity": 2}
{"drug1": "estazolam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with butalbital.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Empagliflozin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with triamterene.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Pomalidomide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with dantrolene.", "severity": 2}
{"drug1": "quazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Mersalyl.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with pimozide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with mesoridazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with irbesartan.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with atenolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with thalidomide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with felodipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Sacubitril.", "severity": 2}
{"drug1": "prazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with citalopram.", "severity": 2}
{"drug1": "nimodipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with papaverine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Agomelatine.", "severity": 2}
{"drug1": "trapidil", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Articaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Pipamperone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with polythiazide.", "severity": 2}
{"drug1": "trazodone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with trimipramine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with triamterene.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with nisoldipine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with HEROIN.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with triprolidine.", "severity": 2}
{"drug1": "pargyline", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "promazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with mefenamic acid.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Pipamperone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with edrophonium.", "severity": 2}
{"drug1": "topiramate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with clonidine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with GUANFACINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with propofol.", "severity": 2}
{"drug1": "prednisone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with NAPROXEN.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Lorcaserin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Nilotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Nilotinib.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with selegiline.", "severity": 2}
{"drug1": "sulpiride", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Butethal", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Olopatadine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with pimozide.", "severity": 2}
{"drug1": "benazepril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with suprofen.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with efavirenz.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with trimipramine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Imatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Imatinib.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with equilin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with acebutolol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SAQUINAVIR is combined with Abemaciclib.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dabigatran etexilate is combined with Nintedanib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with benazepril.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with topiramate.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "azelastine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with halcinonide.", "severity": 2}
{"drug1": "bepridil", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Tolcapone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Tasimelteon.", "severity": 2}
{"drug1": "resveratrol", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with equilin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Risedronic acid.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with hydromorphone.", "severity": 2}
{"drug1": "omeprazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when omeprazole is combined with atorvastatin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with selegiline.", "severity": 2}
{"drug1": "enalapril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with DEZOCINE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with ergocalciferol.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with haloperidol.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with acemetacin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with methylprednisolone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with fluoxetine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with SUFENTANIL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with rizatriptan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with naratriptan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with isoniazid.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Olopatadine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Melatonin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with haloperidol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with SERATRODAST.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with fluvastatin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Vecuronium.", "severity": 2}
{"drug1": "buspirone", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with butorphanol.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Rosuvastatin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with promethazine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with sertraline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with benazepril.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Trospium", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with methscopolamine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "plicamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with plicamycin.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with antipyrine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with flunarizine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with losartan.", "severity": 2}
{"drug1": "triamterene", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with nisoldipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with terazosin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with doxazosin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with AMILORIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with duloxetine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Perospirone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with fluoxetine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "formestane", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with pyridostigmine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with sertraline.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Flibanserin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Aceprometazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Eszopiclone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Retigabine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Risedronic acid.", "severity": 2}
{"drug1": "flumethasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with decamethonium.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with MOLINDONE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with NICORANDIL.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with prazosin.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with cetirizine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with protriptyline.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with nifedipine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Difenoxin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Tasimelteon.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Mometasone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Potassium citrate.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Frovatriptan.", "severity": 2}
{"drug1": "dibucaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with topiramate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with DEZOCINE.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with clenbuterol.", "severity": 2}
{"drug1": "bepridil", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with propofol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Aceclofenac.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "baclofen", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with phenytoin.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with phenytoin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with duloxetine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with amisulpride.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with fexofenadine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Levocetirizine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with triamterene.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with vigabatrin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with loteprednol.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Perospirone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with atenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with propoxyphene.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with nabumetone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with enalapril.", "severity": 2}
{"drug1": "Artesunate", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artesunate is combined with dapsone.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with nadolol.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with diflorasone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Aceprometazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Regorafenib.", "severity": 2}
{"drug1": "zotepine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with nortriptyline.", "severity": 2}
{"drug1": "zotepine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with amoxapine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with betaxolol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Difenoxin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with efavirenz.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with mecamylamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Eprosartan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with clorazepate.", "severity": 2}
{"drug1": "methysergide", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with dihydroergotamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with sulpiride.", "severity": 2}
{"drug1": "tizanidine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with vigabatrin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with tolfenamic acid.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with protriptyline.", "severity": 2}
{"drug1": "lidocaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with carisoprodol.", "severity": 2}
{"drug1": "ramipril", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with AMILORIDE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Iloperidone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Flibanserin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Butethal.", "severity": 2}
{"drug1": "dantrolene", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "dantrolene", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with flunarizine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Zoledronic acid.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with amcinonide.", "severity": 2}
{"drug1": "topiramate", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with ethotoin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with methazolamide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Eplerenone.", "severity": 2}
{"drug1": "ramipril", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with doxazosin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with maprotiline.", "severity": 2}
{"drug1": "Halazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with amisulpride.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with lithium ion.", "severity": 2}
{"drug1": "bepridil", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Empagliflozin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Iloperidone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with haloperidol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Iloperidone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Eplerenone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with methazolamide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with flumethasone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with methazolamide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Eplerenone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with nicardipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "ramipril", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with labetalol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with maprotiline.", "severity": 2}
{"drug1": "morniflumate", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with tolmetin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with meperidine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Etoricoxib.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with timolol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with quazepam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with propranolol.", "severity": 2}
{"drug1": "miconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with HEROIN.", "severity": 2}
{"drug1": "gabapentin", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with amisulpride.", "severity": 2}
{"drug1": "clidinium", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Iloperidone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Fosphenytoin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with papaverine.", "severity": 2}
{"drug1": "loxapine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "docetaxel", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with prednisone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with clomipramine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with amoxapine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with nortriptyline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with clindamycin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with captopril.", "severity": 2}
{"drug1": "procaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Escitalopram.", "severity": 2}
{"drug1": "procaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Fencamfamin.", "severity": 2}
{"drug1": "procaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with chlormezanone.", "severity": 2}
{"drug1": "temazepam", "drug2": "butabarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with butabarbital.", "severity": 2}
{"drug1": "clorazepate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with olanzapine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with flunisolide.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with pirenzepine.", "severity": 2}
{"drug1": "diazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Etoricoxib.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Cis-mdp.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with DESONIDE.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with trimipramine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with METAXALONE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with triflupromazine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with floctafenine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Ketobemidone.", "severity": 2}
{"drug1": "loxapine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pergolide", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Lercanidipine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Normethadone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with fludrocortisone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Hexobarbital.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Butethal.", "severity": 2}
{"drug1": "minocycline", "drug2": "Acitretin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minocycline is combined with Acitretin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with amobarbital.", "severity": 2}
{"drug1": "pergolide", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Caspofungin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with propoxyphene.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Desloratadine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with carisoprodol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with mepivacaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Metipranolol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Phenelzine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Tramadol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with papaverine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with zotepine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with fexofenadine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Etidocaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Fluspirilene.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "5-Fluorouracil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "amifostine", "drug2": "amiodarone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with amiodarone.", "severity": 2}
{"drug1": "buspirone", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with scopolamine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "clomipramine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Etoricoxib.", "severity": 2}
{"drug1": "fenbufen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with triamcinolone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Melatonin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with felodipine.", "severity": 2}
{"drug1": "triazolam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with amisulpride.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with irbesartan.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "labetalol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with salicylic acid.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with terazosin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with fludiazepam.", "severity": 2}
{"drug1": "glutethimide", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with chlorpheniramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with loratadine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Telmisartan.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with furosemide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with ethotoin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with efavirenz.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with prilocaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with tranylcypromine.", "severity": 2}
{"drug1": "estazolam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with triprolidine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Zucapsaicin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with fenoprofen.", "severity": 2}
{"drug1": "estazolam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with methocarbamol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with benazepril.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with vigabatrin.", "severity": 2}
{"drug1": "enflurane", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Melatonin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with nabumetone.", "severity": 2}
{"drug1": "meperidine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chlorothiazide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with procarbazine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with tenoxicam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with dipyridamole.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with maprotiline.", "severity": 2}
{"drug1": "Mometasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with donepezil.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Telithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Telithromycin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with ritodrine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "tirofiban", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with salicylic acid.", "severity": 2}
{"drug1": "equilin", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with butorphanol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with ILOPROST.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with dantrolene.", "severity": 2}
{"drug1": "brotizolam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with methocarbamol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with medrysone.", "severity": 2}
{"drug1": "benazepril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Clevidipine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with triprolidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Difenoxin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with sotalol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with dantrolene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with tretinoin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with brimonidine.", "severity": 2}
{"drug1": "quazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with butalbital.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with prilocaine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with oxymetazoline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with tranylcypromine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Halobetasol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Levetiracetam.", "severity": 2}
{"drug1": "amantadine", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amantadine is combined with bupropion.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with haloperidol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with timolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with desipramine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with amisulpride.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with tiapride.", "severity": 2}
{"drug1": "metolazone", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with deslanoside.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with benazepril.", "severity": 2}
{"drug1": "captopril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with nadolol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Phenelzine.", "severity": 2}
{"drug1": "buspirone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with flunitrazepam.", "severity": 2}
{"drug1": "buspirone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with equilin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with homoharringtonine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with orphenadrine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with chlorothiazide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with meperidine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with pyridostigmine.", "severity": 2}
{"drug1": "halothane", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with primidone.", "severity": 2}
{"drug1": "labetalol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with quetiapine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with dicyclomine.", "severity": 2}
{"drug1": "dopamine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with acebutolol.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with benzocaine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Escitalopram.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with nimesulide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with betamethasone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "clomipramine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with tolazoline.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Efonidipine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Lacidipine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Azelnidipine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Benidipine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with cilnidipine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with pimozide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with estrone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nisoldipine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Teriflunomide.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with benazepril.", "severity": 2}
{"drug1": "brotizolam", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with venlafaxine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with clemastine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with maprotiline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with enflurane.", "severity": 2}
{"drug1": "Torasemide", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with VERAPAMIL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with nalbuphine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with etizolam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with oxazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with thiothixene.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Mephobarbital.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Desloratadine.", "severity": 2}
{"drug1": "propofol", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with lithium ion.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Fencamfamin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with penbutolol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Etidocaine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with mepivacaine.", "severity": 2}
{"drug1": "timolol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Pramocaine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Remoxipride.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with loxapine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Empagliflozin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Pomalidomide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "Torasemide", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with labetalol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with spironolactone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Cariprazine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with doxazosin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with dipyridamole.", "severity": 2}
{"drug1": "Torasemide", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with AMILORIDE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Etidocaine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with mecamylamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with levodopa.", "severity": 2}
{"drug1": "meperidine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with sevoflurane.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with bumetanide.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with oxycodone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "meperidine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Aripiprazole.", "severity": 2}
{"drug1": "meperidine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chlorprothixene.", "severity": 2}
{"drug1": "baclofen", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Difenoxin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with benzyl alcohol.", "severity": 2}
{"drug1": "estazolam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with amisulpride.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Salbutamol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with aspirin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Levocetirizine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with carisoprodol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with niflumic acid.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfamethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfamethazine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfamerazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfamerazine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Pipamperone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with lithium ion.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Cariprazine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with bupropion.", "severity": 2}
{"drug1": "pimozide", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Levobupivacaine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Mometasone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with loxapine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with terazosin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with alprazolam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Eszopiclone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with procarbazine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ibuprofen.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with amisulpride.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Tasimelteon.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Asenapine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Retigabine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with SERTINDOLE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Frovatriptan.", "severity": 2}
{"drug1": "paroxetine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with tiapride.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with cilazapril.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with MOLINDONE.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "tropicamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with tropicamide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with risperidone.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Tramadol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with vigabatrin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Artemether", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with flunarizine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with doxepin.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlortetracycline is combined with ADAPALENE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with benzocaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with fluocinonide.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with imipramine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with proparacaine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Flibanserin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Aceprometazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with efavirenz.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Etidocaine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with imipramine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with dyclonine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ramipril.", "severity": 2}
{"drug1": "methadone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with desipramine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with buprenorphine.", "severity": 2}
{"drug1": "amifostine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with enoxacin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with tiapride.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with HEROIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "citric acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with citric acid.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "valsartan", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with metolazone.", "severity": 2}
{"drug1": "valsartan", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Nitroprusside.", "severity": 2}
{"drug1": "indomethacin", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with difluprednate.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with phenytoin.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Nepafenac.", "severity": 2}
{"drug1": "atenolol", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with diltiazem.", "severity": 2}
{"drug1": "quazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "phentolamine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with quetiapine.", "severity": 2}
{"drug1": "topiramate", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with metformin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with fleroxacin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with tiagabine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with dantrolene.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with methyclothiazide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Olopatadine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with protriptyline.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with cetirizine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with zonisamide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Propiverine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Pramocaine.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with Olsalazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Alvimopan.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with periciazine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with tizanidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with furosemide.", "severity": 2}
{"drug1": "carprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "pergolide", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Linagliptin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Remoxipride.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with droxidopa.", "severity": 2}
{"drug1": "pergolide", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with clomiphene.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Ezetimibe.", "severity": 2}
{"drug1": "promazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with clidinium.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with oxycodone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with trazodone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Clobetasone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Olopatadine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Delorazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Delorazepam is combined with clozapine.", "severity": 2}
{"drug1": "furosemide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with acebutolol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with alprazolam.", "severity": 2}
{"drug1": "furosemide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with captopril.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Ketobemidone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with CARTEOLOL.", "severity": 2}
{"drug1": "tretinoin", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with metolazone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with captopril.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with felbamate.", "severity": 2}
{"drug1": "pargyline", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with lithium ion.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Arbekacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Arbekacin.", "severity": 2}
{"drug1": "midazolam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with trazodone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with quinapril.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "baclofen", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Levetiracetam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Mephobarbital.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with levorphanol.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with fluoxetine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with promazine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with nalbuphine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Demecarium.", "severity": 2}
{"drug1": "linezolid", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Pipamperone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with lisinopril.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with hydrocortisone.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with PROCATEROL.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with Ephedrine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Mometasone.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with methocarbamol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with tofisopam.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with benazepril.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with triprolidine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Lurasidone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Ticagrelor.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with ketamine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nitroglycerin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with MOLINDONE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with alclometasone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with modafinil.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with formestane.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with nisoldipine.", "severity": 2}
{"drug1": "epirizole", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with difluprednate.", "severity": 2}
{"drug1": "epirizole", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with halcinonide.", "severity": 2}
{"drug1": "fusidic acid", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fusidic acid is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "docetaxel", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with IDARUBICIN.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with methocarbamol.", "severity": 2}
{"drug1": "butalbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Pizotifen.", "severity": 2}
{"drug1": "docetaxel", "drug2": "CABAZITAXEL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "methyldopa", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Milnacipran.", "severity": 2}
{"drug1": "docetaxel", "drug2": "podophyllotoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with podophyllotoxin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Metipranolol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with betamethasone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with HEROIN.", "severity": 2}
{"drug1": "procarbazine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with flunarizine.", "severity": 2}
{"drug1": "methadone", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with theobromine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Mephobarbital.", "severity": 2}
{"drug1": "Melatonin", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Articaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with irbesartan.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Lornoxicam.", "severity": 2}
{"drug1": "dapsone", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with Isometheptene.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with felodipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with furazolidone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with nortriptyline.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with efavirenz.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ondansetron", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with MOLINDONE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Trovafloxacin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with meperidine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with ramipril.", "severity": 2}
{"drug1": "loratadine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with ethotoin.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eslicarbazepine acetate is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Fluprednidene.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Halobetasol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with sulpiride.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with HYDROCODONE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with amobarbital.", "severity": 2}
{"drug1": "captopril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Empagliflozin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with GUANFACINE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Aceprometazine.", "severity": 2}
{"drug1": "procaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Normethadone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Oxetacaine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with felbamate.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levalbuterol is combined with atorvastatin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with D-mannitol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with methoxyflurane.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with raloxifene.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Nabilone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with brimonidine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with primidone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with chloral hydrate.", "severity": 2}
{"drug1": "budesonide", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with edrophonium.", "severity": 2}
{"drug1": "reserpine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with quetiapine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with pramipexole.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Apremilast.", "severity": 2}
{"drug1": "diflunisal", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Panobinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Panobinostat.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with venlafaxine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Phenelzine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with clemastine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Teriflunomide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "midazolam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with estazolam.", "severity": 2}
{"drug1": "reserpine", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with fluvoxamine.", "severity": 2}
{"drug1": "midazolam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with dantrolene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with methoxyflurane.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bezafibrate is combined with Ezetimibe.", "severity": 2}
{"drug1": "buspirone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with clonazepam.", "severity": 2}
{"drug1": "biperiden", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with carvedilol.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with methyldopa.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with mirtazapine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with reserpine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with zaltoprofen.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Rotigotine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "butalbital", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with dantrolene.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with amoxapine.", "severity": 2}
{"drug1": "losartan", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with ADAPALENE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nortriptyline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Temsirolimus.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Pipotiazine.", "severity": 2}
{"drug1": "losartan", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with terazosin.", "severity": 2}
{"drug1": "methysergide", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Amrinone.", "severity": 2}
{"drug1": "carprofen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with epirizole.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with lovastatin.", "severity": 2}
{"drug1": "ethanol", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with furazolidone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with benzyl alcohol.", "severity": 2}
{"drug1": "sotalol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with isoxsuprine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "Zucapsaicin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zucapsaicin is combined with atorvastatin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Eplerenone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Frovatriptan.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with methazolamide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with benazepril.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Carbamylcholine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with prazepam.", "severity": 2}
{"drug1": "furosemide", "drug2": "ribostamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with ribostamycin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with fosinopril.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with terazosin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with GUANFACINE.", "severity": 2}
{"drug1": "deferoxamine", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when deferoxamine is combined with prochlorperazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with metolazone.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with diflunisal.", "severity": 2}
{"drug1": "meperidine", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with polythiazide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with donepezil.", "severity": 2}
{"drug1": "tiagabine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with benzphetamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Clevidipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with quazepam.", "severity": 2}
{"drug1": "Nabilone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Doxercalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium acetate is combined with Doxercalciferol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with doxepin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with Demecarium.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with fenbufen.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Paliperidone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with arsenic trioxide.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with morphine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with methyldopa.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Etidocaine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Icatibant.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with cilostazol.", "severity": 2}
{"drug1": "digoxin", "drug2": "adenosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when digoxin is combined with adenosine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with donepezil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with trimipramine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with alclofenac.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Flibanserin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Nebivolol.", "severity": 2}
{"drug1": "budesonide", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with cinoxacin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with penbutolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with NITROUS ACID.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with bumetanide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with ILOPROST.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with eperisone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Salmeterol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with tizanidine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with maprotiline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with furosemide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with methyclothiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with mesoridazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Pregabalin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with maprotiline.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with sotalol.", "severity": 2}
{"drug1": "Benidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with MOLINDONE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Conivaptan.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with citalopram.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Nabilone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Lorcaserin.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Retigabine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Levalbuterol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Halazepam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with antipyrine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Pipotiazine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with felodipine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dorzolamide is combined with primidone.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Amrinone.", "severity": 2}
{"drug1": "loxapine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Articaine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Lormetazepam.", "severity": 2}
{"drug1": "trazodone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Retigabine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with clomiphene.", "severity": 2}
{"drug1": "minoxidil", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with felodipine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with fludiazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with carisoprodol.", "severity": 2}
{"drug1": "trazodone", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with cabergoline.", "severity": 2}
{"drug1": "aspirin", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with homoharringtonine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with nefazodone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Topiroxostat.", "severity": 2}
{"drug1": "trazodone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with butalbital.", "severity": 2}
{"drug1": "lorazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with methscopolamine.", "severity": 2}
{"drug1": "citalopram", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Lurasidone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Deferasirox.", "severity": 2}
{"drug1": "Netupitant", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Netupitant is combined with atorvastatin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with bupivacaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with DESONIDE.", "severity": 2}
{"drug1": "suprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with alclometasone.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Clevidipine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with nylidrin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Torasemide.", "severity": 2}
{"drug1": "codeine", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Salsalate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with oxprenolol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with dipyridamole.", "severity": 2}
{"drug1": "buspirone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with promethazine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with alclometasone.", "severity": 2}
{"drug1": "enalapril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Masoprocol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with isoflurane.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with flunitrazepam.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with topiramate.", "severity": 2}
{"drug1": "oxycodone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "enalapril", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with BISOPROLOL.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Aceprometazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with topiramate.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "amifostine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Etoricoxib.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with amoxapine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with nortriptyline.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with benazepril.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Desloratadine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with GUANFACINE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with halothane.", "severity": 2}
{"drug1": "docetaxel", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with homoharringtonine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Nilotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Nilotinib.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Milnacipran.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "loxapine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with zotepine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with MELPERONE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with DESONIDE.", "severity": 2}
{"drug1": "epinastine", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with Olsalazine.", "severity": 2}
{"drug1": "warfarin", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when warfarin is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Nabilone", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with captopril.", "severity": 2}
{"drug1": "buspirone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with prilocaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Ropivacaine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Nepafenac.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Sacubitril.", "severity": 2}
{"drug1": "Asenapine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Milnacipran.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Etomidate.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with topiramate.", "severity": 2}
{"drug1": "loxapine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with etizolam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Ropivacaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with bupivacaine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with acemetacin.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with nalbuphine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with clorazepate.", "severity": 2}
{"drug1": "procyclidine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with oxymorphone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Ramelteon.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Perospirone.", "severity": 2}
{"drug1": "Butethal", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with ethosuximide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Isometheptene.", "severity": 2}
{"drug1": "Nabilone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with maprotiline.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with acemetacin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Fencamfamin.", "severity": 2}
{"drug1": "promazine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with estazolam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with brotizolam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "propofol", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with terazosin.", "severity": 2}
{"drug1": "triazolam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Retigabine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Ramelteon.", "severity": 2}
{"drug1": "clozapine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with brotizolam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Tasimelteon.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Benidipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Fencamfamin.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with venlafaxine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with nicardipine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Cyamemazine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "imipramine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with hydralazine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Clevidipine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Ramelteon.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with ramipril.", "severity": 2}
{"drug1": "flunisolide", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with malathion.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with pravastatin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Lacidipine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with valsartan.", "severity": 2}
{"drug1": "flunisolide", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with nalidixic acid.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with hydrocortisone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Desloratadine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with methadone.", "severity": 2}
{"drug1": "tropicamide", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with topiramate.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with terazosin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with mepivacaine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with scopolamine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with trimipramine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Articaine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with nitroglycerin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Riociguat.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with levodopa.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with dantrolene.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Iloperidone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Propoxycaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with tetracaine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with metaproterenol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Pramocaine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with dibucaine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with tetracaine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with oxymetazoline.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Pipotiazine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with nifedipine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with cilazapril.", "severity": 2}
{"drug1": "spironolactone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with papaverine.", "severity": 2}
{"drug1": "morphine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Retigabine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with benzphetamine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with ritodrine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with amcinonide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with zotepine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with CLONIXIN.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with tolfenamic acid.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Droxicam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "tretinoin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Belinostat", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Belinostat is combined with clozapine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with flunarizine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Fluspirilene.", "severity": 2}
{"drug1": "labetalol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with indapamide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Pizotifen.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "ropinirole", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with losartan.", "severity": 2}
{"drug1": "glutethimide", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with scopolamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with HEROIN.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with baclofen.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Clobetasone.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "midodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with midodrine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Oxetacaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "propantheline", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Desloratadine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with barnidipine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Ramelteon.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Metipranolol.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with captopril.", "severity": 2}
{"drug1": "zotepine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with meclizine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with acebutolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with irbesartan.", "severity": 2}
{"drug1": "Trospium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Tapentadol.", "severity": 2}
{"drug1": "clozapine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with minoxidil.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with acemetacin.", "severity": 2}
{"drug1": "codeine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with quazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with prazepam.", "severity": 2}
{"drug1": "metolazone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with dipyridamole.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "codeine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "triprolidine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with loratadine.", "severity": 2}
{"drug1": "codeine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with oxprenolol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Articaine.", "severity": 2}
{"drug1": "medrysone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Deferasirox.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "gabapentin", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with etizolam.", "severity": 2}
{"drug1": "indapamide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Nebivolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with niflumic acid.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with flunarizine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with quazepam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with maprotiline.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with salicylic acid.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with mesoridazine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Vardenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tadalafil is combined with Vardenafil.", "severity": 2}
{"drug1": "sotalol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with pilocarpine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with doxepin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolbutamide is combined with ethanol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with cetirizine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with thioridazine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Fluprednidene.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with dyclonine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Tasimelteon.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with propoxyphene.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with sulpiride.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with olanzapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with acetaminophen.", "severity": 2}
{"drug1": "pergolide", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ipratropium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with topiramate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Retigabine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with methyldopa.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "captopril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with penbutolol.", "severity": 2}
{"drug1": "etizolam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with clonidine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with memantine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Apremilast", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with salicylamide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with diflorasone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with dantrolene.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Pimecrolimus.", "severity": 2}
{"drug1": "codeine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with baclofen.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Pimecrolimus.", "severity": 2}
{"drug1": "clomipramine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with spironolactone.", "severity": 2}
{"drug1": "codeine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with triamterene.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Milnacipran.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Canagliflozin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ramipril.", "severity": 2}
{"drug1": "triazolam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "isoflurane", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with fluvoxamine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with valsartan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with metolazone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "ramipril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with mefenamic acid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ramipril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with NAPROXEN.", "severity": 2}
{"drug1": "bumetanide", "drug2": "kanamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with kanamycin.", "severity": 2}
{"drug1": "bumetanide", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with IDARUBICIN.", "severity": 2}
{"drug1": "hexetidine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with nimesulide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with vigabatrin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Butethal.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with nicardipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with lithium ion.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with cabergoline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with benzocaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Hexobarbital.", "severity": 2}
{"drug1": "bromazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Riociguat.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Levomilnacipran.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Dapagliflozin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with imipramine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with difluprednate.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Risedronic acid.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with MOLINDONE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with prilocaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with isoflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with ethotoin.", "severity": 2}
{"drug1": "prazosin", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with mecamylamine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Aceprometazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with zonisamide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with fluocinonide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with lisinopril.", "severity": 2}
{"drug1": "furosemide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with nadolol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with tizanidine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Nebivolol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with tranylcypromine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Olopatadine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zidovudine is combined with clozapine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Levocetirizine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Fospropofol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Butethal.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Levocetirizine.", "severity": 2}
{"drug1": "quinapril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with niflumic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with D-mannitol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with benzocaine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Normethadone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with amobarbital.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with vigabatrin.", "severity": 2}
{"drug1": "prazosin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with isocarboxazid.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Risedronic acid.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with nortriptyline.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with amoxapine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Escitalopram.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with moclobemide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with gabapentin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Zoledronic acid.", "severity": 2}
{"drug1": "metaraminol", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with dopamine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with bicalutamide.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with topiramate.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Flibanserin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with tolfenamic acid.", "severity": 2}
{"drug1": "ketamine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Mephobarbital.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Loxoprofen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Remoxipride.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "estazolam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with trazodone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with CLONIXIN.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with protriptyline.", "severity": 2}
{"drug1": "diazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with trimipramine.", "severity": 2}
{"drug1": "diazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with procaine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Ketobemidone.", "severity": 2}
{"drug1": "ramipril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "dapsone", "drug2": "flutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with flutamide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with triamcinolone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with tretinoin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with felbamate.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with glutethimide.", "severity": 2}
{"drug1": "loratadine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with doxepin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with fexofenadine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with sevoflurane.", "severity": 2}
{"drug1": "propofol", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "pentazocine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with indapamide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with manidipine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with potassium ion.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Halazepam.", "severity": 2}
{"drug1": "apomorphine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with hydralazine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with flumethasone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Asenapine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with tizanidine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with furosemide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with diflorasone.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "halothane", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "halothane", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with tolazoline.", "severity": 2}
{"drug1": "halothane", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "bromazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with dibucaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Asenapine.", "severity": 2}
{"drug1": "topiramate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with butorphanol.", "severity": 2}
{"drug1": "pramipexole", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Canrenoic acid.", "severity": 2}
{"drug1": "benazepril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with tenoxicam.", "severity": 2}
{"drug1": "diltiazem", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with papaverine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with flunisolide.", "severity": 2}
{"drug1": "benazepril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with nabumetone.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Temsirolimus is combined with clozapine.", "severity": 2}
{"drug1": "benazepril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ketorolac.", "severity": 2}
{"drug1": "isradipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with hydralazine.", "severity": 2}
{"drug1": "captopril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with antipyrine.", "severity": 2}
{"drug1": "benazepril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with niflumic acid.", "severity": 2}
{"drug1": "halothane", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with triprolidine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Lumiracoxib.", "severity": 2}
{"drug1": "halothane", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with spironolactone.", "severity": 2}
{"drug1": "halothane", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with methocarbamol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with isoxsuprine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Naftifine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with methyclothiazide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with prednisone.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with nalbuphine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with formoterol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with loratadine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Benidipine.", "severity": 2}
{"drug1": "prazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with meclizine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Torasemide.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with cyclophosphamide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Tolcapone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with amitriptyline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with dibucaine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with MELPERONE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Propacetamol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Artemether", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with nifedipine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with flunisolide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with codeine.", "severity": 2}
{"drug1": "diazepam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with DESFLURANE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with bumetanide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "pentobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with pentobarbital.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with chlorothiazide.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Tramadol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Efonidipine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with nefazodone.", "severity": 2}
{"drug1": "midodrine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with terbutaline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Clodronic Acid.", "severity": 2}
{"drug1": "trazodone", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Thioproperazine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with loratadine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with imipramine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with orphenadrine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Clevidipine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Dapagliflozin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pizotifen.", "severity": 2}
{"drug1": "brotizolam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with clonidine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Flupentixol.", "severity": 2}
{"drug1": "meperidine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with clidinium.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Perospirone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with mesoridazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Conivaptan.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Ketobemidone.", "severity": 2}
{"drug1": "prazosin", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with apraclonidine.", "severity": 2}
{"drug1": "baclofen", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "sotalol", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with benazepril.", "severity": 2}
{"drug1": "hexetidine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with nitrendipine.", "severity": 2}
{"drug1": "amifostine", "drug2": "Arotinolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Arotinolol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with oxymorphone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with amitriptyline.", "severity": 2}
{"drug1": "EDTA", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EDTA is combined with Nintedanib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "altretamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with altretamine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with zopiclone.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with doxepin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with primidone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with resveratrol.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with nefazodone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Escitalopram.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Normethadone.", "severity": 2}
{"drug1": "clozapine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with trifluoperazine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with meclofenamic acid.", "severity": 2}
{"drug1": "tolmetin", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with salicylic acid.", "severity": 2}
{"drug1": "lorazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "methadone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Melatonin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with hydralazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "morphine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with losartan.", "severity": 2}
{"drug1": "etizolam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with levodopa.", "severity": 2}
{"drug1": "tetracaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with vigabatrin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with HEROIN.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with isoxsuprine.", "severity": 2}
{"drug1": "methadone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with butalbital.", "severity": 2}
{"drug1": "procarbazine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with rasagiline.", "severity": 2}
{"drug1": "procarbazine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with PROCATEROL.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Articaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with doxepin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with irinotecan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with methimazole.", "severity": 2}
{"drug1": "trazodone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "furosemide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with GUANFACINE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with moclobemide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with spironolactone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Escitalopram.", "severity": 2}
{"drug1": "thiopental", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with tetracaine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Clevidipine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Mephobarbital.", "severity": 2}
{"drug1": "zaleplon", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with oxazepam.", "severity": 2}
{"drug1": "dobutamine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with terbutaline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with nalbuphine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with doxepin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with vincristine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Propoxycaine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with nefazodone.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BOPINDOLOL is combined with Carbamylcholine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with zafirlukast.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Pramocaine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with memantine.", "severity": 2}
{"drug1": "selegiline", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with losartan.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Bortezomib.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with apraclonidine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Normethadone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with oxprenolol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "enflurane", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with cetirizine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with salicylic acid.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with pravastatin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with triamcinolone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with paroxetine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "topiramate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Pomalidomide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with DEZOCINE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Octreotide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Octreotide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Ketobemidone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Zoledronic acid.", "severity": 2}
{"drug1": "quazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "nimesulide", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "reserpine", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with deslanoside.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with doxepin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Halobetasol.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with clidinium.", "severity": 2}
{"drug1": "reserpine", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with diphenhydramine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with nefazodone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with tetracaine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Articaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with enalapril.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with nilvadipine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomepromazine is combined with methylphenidate.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Sacubitril.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Pomalidomide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ramipril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with valsartan.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambenonium is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Butethal.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with triamcinolone.", "severity": 2}
{"drug1": "morphine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with tetracaine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with isoxsuprine.", "severity": 2}
{"drug1": "methadone", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Thioproperazine.", "severity": 2}
{"drug1": "aspirin", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Pramocaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with tranylcypromine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with ambenonium.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with prilocaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with pimozide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Isometheptene.", "severity": 2}
{"drug1": "brimonidine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "zonisamide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with timolol.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with apraclonidine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with dichlorphenamide.", "severity": 2}
{"drug1": "trazodone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with amoxapine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with salicylamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with prazepam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with tretinoin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with ethotoin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Axitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Axitinib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lovastatin is combined with oxycodone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with phenytoin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with METAXALONE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with enflurane.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with fluoxetine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with doxepin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nicardipine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Tramadol.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with dipyridamole.", "severity": 2}
{"drug1": "butorphanol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with primidone.", "severity": 2}
{"drug1": "buspirone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with topiramate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with GUANFACINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with oxprenolol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with MELPERONE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with zotepine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with thiothixene.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with enoxacin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with irbesartan.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Pixantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Pixantrone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with salicylamide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Normethadone.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "methyldopa", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "methyldopa", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with felodipine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with brotizolam.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with amcinonide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with trimipramine.", "severity": 2}
{"drug1": "methysergide", "drug2": "roxithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with roxithromycin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with procaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with apraclonidine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Telmisartan.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with vigabatrin.", "severity": 2}
{"drug1": "methysergide", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with etoposide.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Pentolinium.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with clozapine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Eplerenone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "labetalol", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with nylidrin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with spironolactone.", "severity": 2}
{"drug1": "trazodone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with methocarbamol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with methocarbamol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with prednisone.", "severity": 2}
{"drug1": "trazodone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with triprolidine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with triprolidine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with niflumic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Milnacipran.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "terconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with DEZOCINE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Difenoxin.", "severity": 2}
{"drug1": "Articaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "pergolide", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with nilvadipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with bromocriptine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Levetiracetam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with levodopa.", "severity": 2}
{"drug1": "cocaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with etizolam.", "severity": 2}
{"drug1": "terconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with trimipramine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with alclometasone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Flibanserin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with efavirenz.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with minoxidil.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Iloperidone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "procyclidine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with tubocurarine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with chlorprothixene.", "severity": 2}
{"drug1": "Asenapine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with zonisamide.", "severity": 2}
{"drug1": "ramipril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Loxoprofen.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "ketamine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with clomipramine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with brotizolam.", "severity": 2}
{"drug1": "Asenapine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with tiagabine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with ondansetron.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with tetracaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with propofol.", "severity": 2}
{"drug1": "anagrelide", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Olopatadine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Lormetazepam.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with resveratrol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with flunitrazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "codeine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "tropicamide", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with tolterodine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Aceclofenac.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with AMILORIDE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with DEZOCINE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with pilocarpine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with resveratrol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with quetiapine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with isoxsuprine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with moclobemide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with SERATRODAST.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Levetiracetam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "5-azacytidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with 5-azacytidine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with isoetharine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chlorprothixene.", "severity": 2}
{"drug1": "cetirizine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zotepine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with butalbital.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Paliperidone.", "severity": 2}
{"drug1": "metolazone", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with captopril.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with tiapride.", "severity": 2}
{"drug1": "olanzapine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Ciclesonide.", "severity": 2}
{"drug1": "Articaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with ethosuximide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with tacrolimus.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with periciazine.", "severity": 2}
{"drug1": "etizolam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with clidinium.", "severity": 2}
{"drug1": "loxapine", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "rapamycin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with xylometazoline.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Canagliflozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "carboplatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with carboplatin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with methylprednisolone.", "severity": 2}
{"drug1": "Articaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with primidone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Apremilast.", "severity": 2}
{"drug1": "losartan", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Nepafenac.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with desipramine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with carprofen.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with scopolamine.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asunaprevir is combined with meperidine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with isoetharine.", "severity": 2}
{"drug1": "Articaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with efavirenz.", "severity": 2}
{"drug1": "naratriptan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with prochlorperazine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with captopril.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with METAXALONE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nortriptyline.", "severity": 2}
{"drug1": "flurazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with baclofen.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with benazepril.", "severity": 2}
{"drug1": "procaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Difenoxin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Bambuterol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Ketobemidone.", "severity": 2}
{"drug1": "propofol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Temsirolimus.", "severity": 2}
{"drug1": "proparacaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with butalbital.", "severity": 2}
{"drug1": "promazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with dantrolene.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with cinoxacin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with thiopental.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with etizolam.", "severity": 2}
{"drug1": "pramipexole", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with dipyridamole.", "severity": 2}
{"drug1": "thioridazine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with flurazepam.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with epirizole.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with tolterodine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with flunarizine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Fluspirilene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with butamben.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with indomethacin.", "severity": 2}
{"drug1": "tiapride", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with cetirizine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Difenoxin.", "severity": 2}
{"drug1": "Amrinone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with atorvastatin.", "severity": 2}
{"drug1": "codeine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with zaleplon.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with efavirenz.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with periciazine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Lomitapide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with apraclonidine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Lercanidipine.", "severity": 2}
{"drug1": "prazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "triamterene", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Etomidate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Escitalopram.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with loxapine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with nicardipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with MOLINDONE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with acebutolol.", "severity": 2}
{"drug1": "loxapine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with nitrazepam.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with pyridostigmine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with butamben.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Levobupivacaine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with methadone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with ethotoin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with desipramine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with fleroxacin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Articaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with tranylcypromine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with diflunisal.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Etomidate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with bupivacaine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with bumetanide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with nimodipine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Pramocaine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with chlorothiazide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with pilocarpine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with clidinium.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Tolcapone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with vigabatrin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with mesoridazine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with methylprednisolone.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when daunorubicin is combined with leflunomide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with maprotiline.", "severity": 2}
{"drug1": "ramipril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Pregabalin.", "severity": 2}
{"drug1": "reserpine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with losartan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with procarbazine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Salmeterol.", "severity": 2}
{"drug1": "reserpine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with thioridazine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with imipramine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Aliskiren.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with loratadine.", "severity": 2}
{"drug1": "propranolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with penbutolol.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Amrinone.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with clozapine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with METAXALONE.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with galanthamine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Ketobemidone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Isoflurophate.", "severity": 2}
{"drug1": "sertraline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Thioproperazine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with proparacaine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Clevidipine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Ropivacaine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with bupivacaine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with chlorpheniramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Etomidate.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pipamperone.", "severity": 2}
{"drug1": "enalapril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Olsalazine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with glutethimide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Milnacipran.", "severity": 2}
{"drug1": "dibucaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with scopolamine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with topiramate.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Bretylium.", "severity": 2}
{"drug1": "doxepin", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with metaproterenol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "dicumarol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with dicumarol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with chlorthalidone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with maprotiline.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Tolvaptan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with amobarbital.", "severity": 2}
{"drug1": "atenolol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with etizolam.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with alclofenac.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with meperidine.", "severity": 2}
{"drug1": "Metixene", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with meperidine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with nimesulide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Alvimopan.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with felbamate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with clomipramine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with ethotoin.", "severity": 2}
{"drug1": "modafinil", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when modafinil is combined with atorvastatin.", "severity": 2}
{"drug1": "loxapine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Aripiprazole.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Fesoterodine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Pipamperone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Suvorexant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Suvorexant.", "severity": 2}
{"drug1": "anagrelide", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with cilostazol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "ramipril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "quetiapine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with glutethimide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with zotepine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with MELPERONE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Olaparib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Olaparib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Riociguat.", "severity": 2}
{"drug1": "clorazepate", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with loratadine.", "severity": 2}
{"drug1": "miconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with nimodipine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with flurandrenolide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Mometasone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with prazosin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Olopatadine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Oxetacaine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Clevidipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Difenoxin.", "severity": 2}
{"drug1": "caffeine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when caffeine is combined with atorvastatin.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with acebutolol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with meclizine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with zonisamide.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with captopril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with methyclothiazide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with tiagabine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with PAMABROM.", "severity": 2}
{"drug1": "labetalol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with papaverine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Telmisartan.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with flurbiprofen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with fenbufen.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Degarelix", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Degarelix.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Iloperidone.", "severity": 2}
{"drug1": "baclofen", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with desipramine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Hexobarbital.", "severity": 2}
{"drug1": "quinidine", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with mefloquine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with lithium ion.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with amobarbital.", "severity": 2}
{"drug1": "valsartan", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Masoprocol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Butethal.", "severity": 2}
{"drug1": "clonidine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with lisinopril.", "severity": 2}
{"drug1": "buspirone", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Almotriptan.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Clobetasone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with etizolam.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with nefazodone.", "severity": 2}
{"drug1": "baclofen", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with clemastine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Asenapine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with Clevidipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with triazolam.", "severity": 2}
{"drug1": "Normethadone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with clonidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with maprotiline.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Salsalate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with nortriptyline.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with amoxapine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Propacetamol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Enalaprilat.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "ketoconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atorvastatin is combined with ketoconazole.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with trifluoperazine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with zopiclone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with mirtazapine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with captopril.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with benzocaine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with vigabatrin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "loxapine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with butamben.", "severity": 2}
{"drug1": "estazolam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with fexofenadine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Pizotifen.", "severity": 2}
{"drug1": "ketamine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with enflurane.", "severity": 2}
{"drug1": "indapamide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with sulpiride.", "severity": 2}
{"drug1": "indapamide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with digoxin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Etidocaine.", "severity": 2}
{"drug1": "codeine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chlormezanone.", "severity": 2}
{"drug1": "desipramine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with SERTINDOLE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with celiprolol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with fluoxetine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Pizotifen.", "severity": 2}
{"drug1": "codeine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with duloxetine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with selegiline.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Drospirenone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Flibanserin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with nifedipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with midazolam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with bromazepam.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Salsalate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with topiramate.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Valrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Valrubicin.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with triflupromazine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Pizotifen.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with haloperidol.", "severity": 2}
{"drug1": "etizolam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Thioproperazine.", "severity": 2}
{"drug1": "etizolam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Ramelteon.", "severity": 2}
{"drug1": "cerulenin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with nitrendipine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "anagrelide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with anagrelide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with MOLINDONE.", "severity": 2}
{"drug1": "Limaprost", "drug2": "dicumarol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with dicumarol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with epoprostenol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with phenytoin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with metoprolol.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Aliskiren.", "severity": 2}
{"drug1": "Metixene", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with duloxetine.", "severity": 2}
{"drug1": "reserpine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with hydralazine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with vigabatrin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with fluoxetine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with mianserin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "ramipril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Etoricoxib.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Methadyl acetate.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with SERTINDOLE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Phenelzine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with glutethimide.", "severity": 2}
{"drug1": "captopril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Propacetamol.", "severity": 2}
{"drug1": "captopril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Olsalazine.", "severity": 2}
{"drug1": "methadone", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with cocaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with tiagabine.", "severity": 2}
{"drug1": "loxapine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with meclizine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with ondansetron.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "butenafine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with isradipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Canagliflozin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atorvastatin is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "sulpiride", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with clemastine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "bifonazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "bifonazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with atorvastatin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "glutethimide", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with HEROIN.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bicalutamide is combined with atorvastatin.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with fluvastatin.", "severity": 2}
{"drug1": "codeine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with enflurane.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Retigabine.", "severity": 2}
{"drug1": "clozapine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with losartan.", "severity": 2}
{"drug1": "mesalamine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with desoximetasone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Cis-mdp.", "severity": 2}
{"drug1": "methadone", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Flibanserin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with losartan.", "severity": 2}
{"drug1": "metolazone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Empagliflozin.", "severity": 2}
{"drug1": "midazolam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with lidocaine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with digoxin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with sulpiride.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with secobarbital.", "severity": 2}
{"drug1": "cabergoline", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with imipramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with chloral hydrate.", "severity": 2}
{"drug1": "Tramadol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "timolol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with methyldopa.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Trifluridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Trifluridine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with tizanidine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "potassium chloride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with potassium chloride.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with maprotiline.", "severity": 2}
{"drug1": "tretinoin", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with indapamide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with nicotinamide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with rivastigmine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Demecarium.", "severity": 2}
{"drug1": "ramipril", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with clonidine.", "severity": 2}
{"drug1": "Articaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with etizolam.", "severity": 2}
{"drug1": "ramipril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with fenoprofen.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with scopolamine.", "severity": 2}
{"drug1": "ramipril", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with propranolol.", "severity": 2}
{"drug1": "triazolam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with flunarizine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "azelastine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with homoharringtonine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with oxymetholone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with aspirin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with pimozide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Olopatadine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with AMILORIDE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "methyldopa", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with isoxsuprine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with gabapentin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with labetalol.", "severity": 2}
{"drug1": "triazolam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with amitriptyline.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with tetracaine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with flumethasone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Ropivacaine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Levocetirizine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with ethosuximide.", "severity": 2}
{"drug1": "enflurane", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with bupivacaine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with butalbital.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nortriptyline.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with desoximetasone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "linezolid", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Flupentixol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with felbamate.", "severity": 2}
{"drug1": "reserpine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "benztropine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with pravastatin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with maprotiline.", "severity": 2}
{"drug1": "alprazolam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with SUFENTANIL.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Lurasidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Agomelatine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with nitroglycerin.", "severity": 2}
{"drug1": "trazodone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with DEZOCINE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with niflumic acid.", "severity": 2}
{"drug1": "Propiverine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with topiramate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with topiramate.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with clomipramine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Halobetasol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with atenolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with hydralazine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with cilazapril.", "severity": 2}
{"drug1": "dapsone", "drug2": "sulfadiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with sulfadiazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with ambenonium.", "severity": 2}
{"drug1": "eperisone", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with simvastatin.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with prazosin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Phenelzine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with D-mannitol.", "severity": 2}
{"drug1": "isradipine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with chlorthalidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with citalopram.", "severity": 2}
{"drug1": "enflurane", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with triprolidine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with methylphenidate.", "severity": 2}
{"drug1": "quetiapine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with methocarbamol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Bretylium.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with vigabatrin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with butalbital.", "severity": 2}
{"drug1": "barnidipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with dipyridamole.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Articaine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with sulfasalazine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with pentazocine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Propiverine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with bupivacaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Ropivacaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with morphine.", "severity": 2}
{"drug1": "diazepam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with quetiapine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Enasidenib.", "severity": 2}
{"drug1": "butamben", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with ethotoin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with flunitrazepam.", "severity": 2}
{"drug1": "biperiden", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with orphenadrine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Pipamperone.", "severity": 2}
{"drug1": "thiopental", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with METAXALONE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Difenoxin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Risedronic acid.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "perphenazine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with fexofenadine.", "severity": 2}
{"drug1": "suprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "captopril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with alclofenac.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with tubocurarine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Deferasirox.", "severity": 2}
{"drug1": "amobarbital", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with mepivacaine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Zoledronic acid.", "severity": 2}
{"drug1": "pancuronium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with oxycodone.", "severity": 2}
{"drug1": "chloroxine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with bepridil.", "severity": 2}
{"drug1": "valsartan", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with dipyridamole.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Olopatadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with buspirone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with diltiazem.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Droxicam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with zotepine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with MELPERONE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with fexofenadine.", "severity": 2}
{"drug1": "terconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with clomipramine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with triflupromazine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Empagliflozin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nimodipine.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Isotretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when demeclocycline is combined with Isotretinoin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with digoxin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with proparacaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Halazepam.", "severity": 2}
{"drug1": "suprofen", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Lumiracoxib.", "severity": 2}
{"drug1": "phentolamine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with tretinoin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Clevidipine.", "severity": 2}
{"drug1": "propofol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with flunarizine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with nortriptyline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with amoxapine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with benazepril.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with rescinnamine.", "severity": 2}
{"drug1": "morphine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with tizanidine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with dexamethasone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Pitavastatin.", "severity": 2}
{"drug1": "midodrine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with oxymetazoline.", "severity": 2}
{"drug1": "temazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "amifostine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with ILOPROST.", "severity": 2}
{"drug1": "procaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Desloratadine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Tixocortol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Levocetirizine.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with enalapril.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with amisulpride.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Tasimelteon.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Perospirone.", "severity": 2}
{"drug1": "sulindac", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with salicylamide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with NICORANDIL.", "severity": 2}
{"drug1": "imipramine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Olopatadine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with tizanidine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with epinephrine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with carvedilol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with fluocinonide.", "severity": 2}
{"drug1": "trazodone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with rasagiline.", "severity": 2}
{"drug1": "nimodipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with captopril.", "severity": 2}
{"drug1": "meperidine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Oxetacaine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aminophylline is combined with formoterol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Difenoxin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with flunarizine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with clidinium.", "severity": 2}
{"drug1": "metolazone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with DEZOCINE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with amobarbital.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Flibanserin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Normethadone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Levetiracetam.", "severity": 2}
{"drug1": "cetirizine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with carisoprodol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with butalbital.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with tizanidine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with furosemide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with loteprednol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with enflurane.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with daunorubicin.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Normethadone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "meperidine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with rizatriptan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with SERTINDOLE.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with nalbuphine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with raloxifene.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Tixocortol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with etodolac.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with ZILEUTON.", "severity": 2}
{"drug1": "tolmetin", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with hydrocortisone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Milnacipran.", "severity": 2}
{"drug1": "quazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with ketoprofen.", "severity": 2}
{"drug1": "Asenapine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with procaine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "aspirin", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with flurandrenolide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Lormetazepam.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with fexofenadine.", "severity": 2}
{"drug1": "zotepine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Tasimelteon.", "severity": 2}
{"drug1": "zonisamide", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with clomipramine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with prilocaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with carisoprodol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Fospropofol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with loteprednol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with ramipril.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Cis-mdp.", "severity": 2}
{"drug1": "dibucaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with fludiazepam.", "severity": 2}
{"drug1": "timolol", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with nicardipine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with mefenamic acid.", "severity": 2}
{"drug1": "pimozide", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with ethosuximide.", "severity": 2}
{"drug1": "triamterene", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with nadolol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with pentazocine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with trazodone.", "severity": 2}
{"drug1": "pimozide", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with thiopental.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with chlormezanone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with nalidixic acid.", "severity": 2}
{"drug1": "imipramine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with doxepin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with donepezil.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with malathion.", "severity": 2}
{"drug1": "prednisone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with mefloquine.", "severity": 2}
{"drug1": "imipramine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Escitalopram.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with loteprednol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with diltiazem.", "severity": 2}
{"drug1": "nimesulide", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with estrone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "pargyline", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with ritodrine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Bretylium.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Clevidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with suprofen.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with loteprednol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Salmeterol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Levobupivacaine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Aliskiren.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with maprotiline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with oxymetazoline.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Fosphenytoin.", "severity": 2}
{"drug1": "morphine", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with metoprolol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Pipotiazine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with spironolactone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Torasemide.", "severity": 2}
{"drug1": "Nabilone", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with citalopram.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Ramelteon.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with rasagiline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with thalidomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "melphalan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with melphalan.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Gatifloxacin.", "severity": 2}
{"drug1": "bepridil", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with glutethimide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "diazepam", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with triazolam.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Vecuronium.", "severity": 2}
{"drug1": "diazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "butalbital", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with felbamate.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with trazodone.", "severity": 2}
{"drug1": "diazepam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Salbutamol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Demecarium.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Tolcapone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with amitriptyline.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with tranylcypromine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Mephobarbital.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with prilocaine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with enalapril.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Ticagrelor.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enasidenib is combined with atorvastatin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Lurasidone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with tofisopam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Mephobarbital.", "severity": 2}
{"drug1": "metoprolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with cilazapril.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Riociguat.", "severity": 2}
{"drug1": "Naftifine", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with carprofen.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with ambenonium.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Metixene.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Aceclofenac.", "severity": 2}
{"drug1": "trandolapril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with zaltoprofen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with leflunomide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nilvadipine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Canagliflozin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with triamcinolone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with butamben.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with fluocinonide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "promazine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with enflurane.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with fluocinonide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with efavirenz.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Pipotiazine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with GUANFACINE.", "severity": 2}
{"drug1": "naratriptan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with thiothixene.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Clobetasone.", "severity": 2}
{"drug1": "estrone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with pyridostigmine.", "severity": 2}
{"drug1": "propantheline", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Vecuronium.", "severity": 2}
{"drug1": "propantheline", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with tizanidine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with baclofen.", "severity": 2}
{"drug1": "propantheline", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with pancuronium.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Risedronic acid.", "severity": 2}
{"drug1": "quazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with zonisamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Normethadone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "RUCAPARIB", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with RUCAPARIB.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with HYDROCODONE.", "severity": 2}
{"drug1": "promethazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with methylprednisolone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Paliperidone.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Tixocortol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with enoxacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with vinorelbine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with benazepril.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with methscopolamine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with butorphanol.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with tolmetin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "azathioprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with azathioprine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with fenbufen.", "severity": 2}
{"drug1": "leflunomide", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "triprolidine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with imipramine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with clidinium.", "severity": 2}
{"drug1": "nimodipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with DEZOCINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nitroglycerin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with trimipramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with procaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with lisinopril.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with vigabatrin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with arsenic trioxide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with oxymorphone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with benzocaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Fencamfamin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with furazolidone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Metixene", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with nalbuphine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with zopiclone.", "severity": 2}
{"drug1": "minocycline", "drug2": "Isotretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minocycline is combined with Isotretinoin.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with pancuronium.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with nortriptyline.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Vecuronium.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with bumetanide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with amoxapine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Lercanidipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with metolazone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with isoetharine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with CARTEOLOL.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with perphenazine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with IDARUBICIN.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with procaine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with prazosin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Zoledronic acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "risperidone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with brotizolam.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with diflunisal.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with floctafenine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Pregabalin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Pramocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Aceprometazine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Propoxycaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with quazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with prazepam.", "severity": 2}
{"drug1": "prilocaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with brotizolam.", "severity": 2}
{"drug1": "methysergide", "drug2": "Imatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Imatinib.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "terconazole", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with lovastatin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with chlorprothixene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Retigabine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "meclizine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with doxepin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nitrous oxide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with equilin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with hydralazine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with levodopa.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with selegiline.", "severity": 2}
{"drug1": "butenafine", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with cinnarizine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Propiverine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with cinoxacin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Retigabine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "isoflurane", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with HEROIN.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Etoricoxib.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with papaverine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SAQUINAVIR is combined with oxycodone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with miconazole.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nifedipine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Frovatriptan.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with difluprednate.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with propoxyphene.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with halcinonide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Flupentixol.", "severity": 2}
{"drug1": "metolazone", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "metolazone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with furosemide.", "severity": 2}
{"drug1": "metolazone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with tizanidine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Propacetamol.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with cilazapril.", "severity": 2}
{"drug1": "temazepam", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with perphenazine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with isoproterenol.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with clomipramine.", "severity": 2}
{"drug1": "metolazone", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with cilazapril.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with HEROIN.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with acetylcholine.", "severity": 2}
{"drug1": "labetalol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with isoxsuprine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with epoprostenol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with clomipramine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with pyridostigmine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with rasagiline.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Metipranolol.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with thiamylal.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with triflupromazine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Telmisartan.", "severity": 2}
{"drug1": "metolazone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with apraclonidine.", "severity": 2}
{"drug1": "metolazone", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with methyldopa.", "severity": 2}
{"drug1": "celecoxib", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with homoharringtonine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with clonazepam.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with DESFLURANE.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "chloroquine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with fenoprofen.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with chlorprothixene.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Oxetacaine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with desoximetasone.", "severity": 2}
{"drug1": "ramipril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with penbutolol.", "severity": 2}
{"drug1": "promazine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Melatonin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with tiagabine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with cocaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with ondansetron.", "severity": 2}
{"drug1": "pramipexole", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with lisinopril.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with zonisamide.", "severity": 2}
{"drug1": "pramipexole", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with nitroglycerin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with methyclothiazide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Etomidate", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with HEROIN.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with chlorthalidone.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with methadone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Perospirone.", "severity": 2}
{"drug1": "prednisone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with ambenonium.", "severity": 2}
{"drug1": "citalopram", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with droperidol.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Pirlindole.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Toloxatone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with homoharringtonine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with methylene blue.", "severity": 2}
{"drug1": "meclizine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with nefazodone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with galanthamine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with Isoflurophate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Ketobemidone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with atorvastatin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with ethotoin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with clomipramine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with fosinopril.", "severity": 2}
{"drug1": "lorazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with tetracaine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with carprofen.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with dantrolene.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with quinidine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with nilvadipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with minoxidil.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Toloxatone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Pirlindole.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Etidocaine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Tolvaptan.", "severity": 2}
{"drug1": "Butethal", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with SERTINDOLE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Cariprazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Caspofungin.", "severity": 2}
{"drug1": "sulconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with estazolam.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with furosemide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Icatibant.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with tizanidine.", "severity": 2}
{"drug1": "temazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Flibanserin.", "severity": 2}
{"drug1": "procaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with carisoprodol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with DEZOCINE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Fluspirilene.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with methadone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with prochlorperazine.", "severity": 2}
{"drug1": "formestane", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with mefloquine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with efavirenz.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with protriptyline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with nitrazepam.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with cetirizine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Telmisartan.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with clidinium.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinorelbine is combined with clozapine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with GUANFACINE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with pilocarpine.", "severity": 2}
{"drug1": "pimozide", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Oxetacaine.", "severity": 2}
{"drug1": "pimozide", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with bromazepam.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Sacubitril.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with clonidine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with trichlormethiazide.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Aceclofenac.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "captopril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with epirizole.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with estrone.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Lorcaserin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with brotizolam.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with diltiazem.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with droxidopa.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with morphine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Ropivacaine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with flunarizine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with triamcinolone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Bretylium.", "severity": 2}
{"drug1": "clorazepate", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with zopiclone.", "severity": 2}
{"drug1": "midazolam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "methyltestosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with methyltestosterone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with oxymorphone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with procaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with METAXALONE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with trimipramine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with vigabatrin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with estrone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Tapentadol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Agomelatine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with triflupromazine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with fenoprofen.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with D-mannitol.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Deferasirox.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "meperidine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with procaine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Zoledronic acid.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Asenapine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nitric oxide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "meperidine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with trimipramine.", "severity": 2}
{"drug1": "propranolol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with acebutolol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with penbutolol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Iloperidone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with methazolamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Eplerenone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with formestane.", "severity": 2}
{"drug1": "Trospium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with butorphanol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with butamben.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with loteprednol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with penbutolol.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "streptomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with streptomycin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with metoclopramide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with brotizolam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with D-mannitol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with triamcinolone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with isoxsuprine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Tixocortol.", "severity": 2}
{"drug1": "enflurane", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with amoxapine.", "severity": 2}
{"drug1": "enflurane", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with nortriptyline.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Riociguat is combined with Empagliflozin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with clidinium.", "severity": 2}
{"drug1": "pimozide", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with benzocaine.", "severity": 2}
{"drug1": "procaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with brotizolam.", "severity": 2}
{"drug1": "sertraline", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with amitriptyline.", "severity": 2}
{"drug1": "pimozide", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with vigabatrin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with PAMABROM.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "alclofenac", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with imipramine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with reserpine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with pilocarpine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with flunarizine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Hexobarbital.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with loratadine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with lithium ion.", "severity": 2}
{"drug1": "pentazocine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with dibucaine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with D-mannitol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Butethal.", "severity": 2}
{"drug1": "pentazocine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with metolazone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with tiapride.", "severity": 2}
{"drug1": "timolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with imipramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with dibucaine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with methyldopa.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with metolazone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with BISOPROLOL.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with CARTEOLOL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Pizotifen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with salicylic acid.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with apraclonidine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Lercanidipine.", "severity": 2}
{"drug1": "procaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Agomelatine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Levobupivacaine.", "severity": 2}
{"drug1": "methadone", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Alvimopan.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "zaleplon", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with enflurane.", "severity": 2}
{"drug1": "decamethonium", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when decamethonium is combined with acetylcholine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with chlorzoxazone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with loratadine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with procaine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Teriflunomide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "nicergoline", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with omeprazole.", "severity": 2}
{"drug1": "antipyrine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with loteprednol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with olanzapine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with HEROIN.", "severity": 2}
{"drug1": "desipramine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Lorcaserin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with scopolamine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with mianserin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with vigabatrin.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with fenbufen.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with bumetanide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with paramethasone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with etizolam.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Propacetamol.", "severity": 2}
{"drug1": "valsartan", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "olanzapine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with trazodone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with haloperidol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with MOLINDONE.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with hydrocortisone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with levodopa.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with periciazine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Paliperidone.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with resveratrol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Droxicam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with zotepine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with butalbital.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with equilin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with ibuprofen.", "severity": 2}
{"drug1": "amobarbital", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "Halazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with glutethimide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with estrone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Halobetasol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with oxazepam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with apraclonidine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Telmisartan.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with methyldopa.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "temazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with dantrolene.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with nitrous oxide.", "severity": 2}
{"drug1": "pimozide", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with ethotoin.", "severity": 2}
{"drug1": "pimozide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with prilocaine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with salicylamide.", "severity": 2}
{"drug1": "pimozide", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with tranylcypromine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with fludiazepam.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with chloral hydrate.", "severity": 2}
{"drug1": "glutethimide", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with loratadine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with fludiazepam.", "severity": 2}
{"drug1": "nystatin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with nimodipine.", "severity": 2}
{"drug1": "clemastine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with METAXALONE.", "severity": 2}
{"drug1": "quinapril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "busulfan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with busulfan.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "methadone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with amoxapine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Flibanserin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Pomalidomide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with thiopental.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with zotepine.", "severity": 2}
{"drug1": "midazolam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with chloral hydrate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with ethosuximide.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ADAPALENE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Pipotiazine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with HEROIN.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with losartan.", "severity": 2}
{"drug1": "estazolam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "oxazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with efavirenz.", "severity": 2}
{"drug1": "maprotiline", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with fexofenadine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Deferasirox.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with rizatriptan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with methyclothiazide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with salicylamide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with primidone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with triamterene.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Arformoterol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Medroxyprogesterone acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with isoxsuprine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Etidocaine.", "severity": 2}
{"drug1": "ramipril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with GUANFACINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with GUANFACINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Olaparib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Olaparib.", "severity": 2}
{"drug1": "codeine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with zotepine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with paroxetine.", "severity": 2}
{"drug1": "clozapine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with meclizine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Fluspirilene.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Nintedanib.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with flunarizine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with maprotiline.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with morphine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with edrophonium.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with thiopental.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with resveratrol.", "severity": 2}
{"drug1": "buspirone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Hexobarbital.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with nitrendipine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Butethal.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with amobarbital.", "severity": 2}
{"drug1": "budesonide", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with leflunomide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with olanzapine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with polythiazide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with brimonidine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with diflorasone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Propoxycaine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Pramocaine.", "severity": 2}
{"drug1": "Retigabine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with duloxetine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with isoxsuprine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Fospropofol.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Apremilast.", "severity": 2}
{"drug1": "bumetanide", "drug2": "streptomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with streptomycin.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with ethotoin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with flurazepam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with brotizolam.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with amoxapine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with tizanidine.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with Pitavastatin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with terazosin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Tolcapone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with dantrolene.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with nefazodone.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with VERAPAMIL.", "severity": 2}
{"drug1": "amcinonide", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with donepezil.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with halcinonide.", "severity": 2}
{"drug1": "enflurane", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with benzocaine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with salicylamide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with doxepin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Pomalidomide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Articaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with amitriptyline.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with pargyline.", "severity": 2}
{"drug1": "Articaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Tolcapone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with indapamide.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Thioproperazine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Tapentadol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with clonidine.", "severity": 2}
{"drug1": "clidinium", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with HEROIN.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with epirizole.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with penbutolol.", "severity": 2}
{"drug1": "midazolam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with equilin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nisoldipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with alprazolam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Remoxipride.", "severity": 2}
{"drug1": "Halazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with ethotoin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with triamcinolone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Normethadone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with sevoflurane.", "severity": 2}
{"drug1": "barnidipine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with lisinopril.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Aripiprazole.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with furosemide.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with oxycodone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "diazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with cetirizine.", "severity": 2}
{"drug1": "suprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with flunisolide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "diazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with protriptyline.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with butalbital.", "severity": 2}
{"drug1": "reserpine", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with alprazolam.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with pentazocine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with alclometasone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with losartan.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Carfilzomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Carfilzomib.", "severity": 2}
{"drug1": "Etomidate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with flunarizine.", "severity": 2}
{"drug1": "Retigabine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Cariprazine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with cyclothiazide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with etizolam.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halofantrine is combined with dapsone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with linezolid.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with ethotoin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with rasagiline.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Oxetacaine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Levalbuterol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with spironolactone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with promazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Normethadone.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with ramipril.", "severity": 2}
{"drug1": "paramethasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with mefloquine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with metoprolol.", "severity": 2}
{"drug1": "itraconazole", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with vincristine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with nitroglycerin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with tizanidine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Agomelatine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Oxetacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Levetiracetam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with amobarbital.", "severity": 2}
{"drug1": "barnidipine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with sevoflurane.", "severity": 2}
{"drug1": "methysergide", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with paramethasone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Demecarium.", "severity": 2}
{"drug1": "methysergide", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Pramocaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with imipramine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pralatrexate is combined with leflunomide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Almotriptan.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with metronidazole.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with betaxolol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Repaglinide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with loratadine.", "severity": 2}
{"drug1": "captopril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Nebivolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with butamben.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with triamcinolone.", "severity": 2}
{"drug1": "furosemide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Riociguat.", "severity": 2}
{"drug1": "resveratrol", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with prochlorperazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Lornoxicam.", "severity": 2}
{"drug1": "enalapril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with nimesulide.", "severity": 2}
{"drug1": "morphine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with protriptyline.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with edrophonium.", "severity": 2}
{"drug1": "morphine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with cetirizine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with atorvastatin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Methadyl acetate.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with GUANFACINE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with sparfloxacin.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "levorphanol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with felbamate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with ILOPROST.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Pipamperone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with ibuprofen.", "severity": 2}
{"drug1": "suprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Normethadone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with sulfanilamide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with indapamide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Doxercalciferol is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "proparacaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with zotepine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with dipyridamole.", "severity": 2}
{"drug1": "HEROIN", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with procarbazine.", "severity": 2}
{"drug1": "clozapine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with HEROIN.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with tizanidine.", "severity": 2}
{"drug1": "azelastine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Tianeptine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with furosemide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with tizanidine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with meperidine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Flupentixol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Propacetamol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with quetiapine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Fluspirilene.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with tiapride.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with ketoprofen.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with chloral hydrate.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with lithium ion.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with fludiazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with etizolam.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with methadone.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with paroxetine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with ambenonium.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Levetiracetam.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Levalbuterol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with indapamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Retigabine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with estrone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with metolazone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ADAPALENE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with rasagiline.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "dobutamine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with dopamine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Aceclofenac.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Milnacipran.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with ethotoin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with isoflurane.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with prilocaine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Clevidipine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with MELPERONE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with zotepine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with oxprenolol.", "severity": 2}
{"drug1": "captopril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with sulindac.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Enalaprilat.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Loxoprofen.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Droxicam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with rescinnamine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with CLONIXIN.", "severity": 2}
{"drug1": "duloxetine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with naratriptan.", "severity": 2}
{"drug1": "dapsone", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with antipyrine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Doxercalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with Doxercalciferol.", "severity": 2}
{"drug1": "thiopental", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with GUANFACINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Nebivolol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with flunitrazepam.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with Ephedrine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with PROCATEROL.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with rivastigmine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with cocaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with tiagabine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Empagliflozin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Agomelatine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with daunorubicin.", "severity": 2}
{"drug1": "triamterene", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with GUANFACINE.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Retigabine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Propacetamol.", "severity": 2}
{"drug1": "tetracaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Escitalopram.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "carprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "cabergoline", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with daunorubicin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with Trovafloxacin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Retigabine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with doxepin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "halothane", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "bepridil", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with pravastatin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with MELPERONE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with amcinonide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Paliperidone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with cetirizine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with protriptyline.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with dantrolene.", "severity": 2}
{"drug1": "ketamine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with tiagabine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "biperiden", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with dicyclomine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Alitretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Alitretinoin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with zonisamide.", "severity": 2}
{"drug1": "biperiden", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with ALFENTANIL.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with dantrolene.", "severity": 2}
{"drug1": "clemastine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with meclizine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with lisinopril.", "severity": 2}
{"drug1": "aspirin", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with estrone.", "severity": 2}
{"drug1": "butamben", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "azelastine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with CLONIXIN.", "severity": 2}
{"drug1": "morphine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with bupivacaine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Loxoprofen.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with mefloquine.", "severity": 2}
{"drug1": "azelastine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Droxicam.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Indacaterol.", "severity": 2}
{"drug1": "morphine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with trifluoperazine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with sulpiride.", "severity": 2}
{"drug1": "primidone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Retigabine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Clobetasone.", "severity": 2}
{"drug1": "promazine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with glutethimide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with atorvastatin.", "severity": 2}
{"drug1": "promazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with etizolam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with tretinoin.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Pefloxacin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nimodipine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with quetiapine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with prednisone.", "severity": 2}
{"drug1": "promazine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with dibucaine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Articaine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with levorphanol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with niflumic acid.", "severity": 2}
{"drug1": "buspirone", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with perphenazine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with acebutolol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Apremilast.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Deferasirox.", "severity": 2}
{"drug1": "oxycodone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with lithium ion.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Phenelzine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with nitrazepam.", "severity": 2}
{"drug1": "pergolide", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Quinupristin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with brotizolam.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Demecarium.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Olsalazine.", "severity": 2}
{"drug1": "valsartan", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with nitroglycerin.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with isradipine.", "severity": 2}
{"drug1": "valsartan", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with lisinopril.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with nicardipine.", "severity": 2}
{"drug1": "suprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "methysergide", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with cabergoline.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Tasimelteon.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Aceprometazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Ziprasidone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Aliskiren.", "severity": 2}
{"drug1": "methysergide", "drug2": "RANOLAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with RANOLAZINE.", "severity": 2}
{"drug1": "estrone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with metoclopramide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Escitalopram.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with flurandrenolide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Tolcapone.", "severity": 2}
{"drug1": "procyclidine", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with hyoscyamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Pizotifen.", "severity": 2}
{"drug1": "oxazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with lithium ion.", "severity": 2}
{"drug1": "sulindac", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with CLONIXIN.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with methocarbamol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with spironolactone.", "severity": 2}
{"drug1": "linezolid", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with quetiapine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with triprolidine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with halcinonide.", "severity": 2}
{"drug1": "codeine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Desloratadine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with mefloquine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Butethal", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Fencamfamin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with triazolam.", "severity": 2}
{"drug1": "brimonidine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with terazosin.", "severity": 2}
{"drug1": "sulindac", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "pentazocine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with METAXALONE.", "severity": 2}
{"drug1": "sulindac", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with amcinonide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Levocetirizine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with equilin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with chlorzoxazone.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with celiprolol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with HEROIN.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Normethadone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with betamethasone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with paroxetine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Etidocaine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "loxapine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with quazepam.", "severity": 2}
{"drug1": "loxapine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with prazepam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with DEZOCINE.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with Olsalazine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with epirizole.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with triamcinolone.", "severity": 2}
{"drug1": "morphine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with zotepine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with ethanol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Salmeterol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with mesoridazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Torasemide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with maprotiline.", "severity": 2}
{"drug1": "triamterene", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Dapagliflozin.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with citalopram.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with cetirizine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Fosphenytoin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with nicotine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Cevimeline.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Etomidate.", "severity": 2}
{"drug1": "proparacaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with mesoridazine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with duloxetine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with fluoxetine.", "severity": 2}
{"drug1": "temazepam", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with meprobamate.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with homoharringtonine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with salicylamide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with chlorzoxazone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Milnacipran.", "severity": 2}
{"drug1": "salicylamide", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with paramethasone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with D-mannitol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Olopatadine.", "severity": 2}
{"drug1": "halothane", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Fospropofol.", "severity": 2}
{"drug1": "salicylamide", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with oxycodone.", "severity": 2}
{"drug1": "halothane", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nilvadipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with apraclonidine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Mersalyl.", "severity": 2}
{"drug1": "Butethal", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with carvedilol.", "severity": 2}
{"drug1": "sulindac", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with diflunisal.", "severity": 2}
{"drug1": "dyclonine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with citalopram.", "severity": 2}
{"drug1": "oxazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with tetracaine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with methyldopa.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with codeine.", "severity": 2}
{"drug1": "valsartan", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with rescinnamine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with nalbuphine.", "severity": 2}
{"drug1": "loxapine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with baclofen.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with clopidogrel.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with antipyrine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Mometasone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with pimozide.", "severity": 2}
{"drug1": "clidinium", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Fosphenytoin.", "severity": 2}
{"drug1": "loxapine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "epinastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with epinastine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with leflunomide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with quetiapine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Riociguat.", "severity": 2}
{"drug1": "glutethimide", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with fexofenadine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Lornoxicam.", "severity": 2}
{"drug1": "sertraline", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with chlorprothixene.", "severity": 2}
{"drug1": "methadone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with thiothixene.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Pipotiazine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Pregabalin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with tizanidine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with ketamine.", "severity": 2}
{"drug1": "cisplatin", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cisplatin is combined with vinorelbine.", "severity": 2}
{"drug1": "cisplatin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cisplatin is combined with clozapine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with hydrocortisone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with sertraline.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Levocetirizine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Alvimopan.", "severity": 2}
{"drug1": "triazolam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with zopiclone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Pizotifen.", "severity": 2}
{"drug1": "ramipril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with resveratrol.", "severity": 2}
{"drug1": "triazolam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with oxymorphone.", "severity": 2}
{"drug1": "prednisone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with donepezil.", "severity": 2}
{"drug1": "Trospium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Paliperidone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with butamben.", "severity": 2}
{"drug1": "procaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with protriptyline.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "morphine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with scopolamine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "procaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with cetirizine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with quinapril.", "severity": 2}
{"drug1": "pramipexole", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with chlorothiazide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "amisulpride", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with scopolamine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with venlafaxine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ketamine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with clidinium.", "severity": 2}
{"drug1": "citalopram", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with periciazine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with scopolamine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with zotepine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with MELPERONE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with enoxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with desoximetasone.", "severity": 2}
{"drug1": "ramipril", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with methazolamide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ketamine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Levobupivacaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with tretinoin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Levocetirizine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when physostigmine is combined with pilocarpine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Ropivacaine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Etidocaine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with mirtazapine.", "severity": 2}
{"drug1": "propantheline", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with topiramate.", "severity": 2}
{"drug1": "gabapentin", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with tiapride.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with paroxetine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Lapatinib.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "cilazapril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with indomethacin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with fexofenadine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Metixene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with butamben.", "severity": 2}
{"drug1": "sertraline", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with nortriptyline.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with quetiapine.", "severity": 2}
{"drug1": "propofol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "propofol", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with tolazoline.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with quetiapine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with ketamine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with simvastatin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Thioproperazine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with thiothixene.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Fencamfamin.", "severity": 2}
{"drug1": "nystatin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with nicardipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with proparacaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with meclizine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with nadolol.", "severity": 2}
{"drug1": "benazepril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Masoprocol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Desloratadine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with donepezil.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Echothiophate.", "severity": 2}
{"drug1": "bumetanide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with cilazapril.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "bepridil", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with methyclothiazide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with duloxetine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with flurandrenolide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with betaxolol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with fexofenadine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with betamethasone.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with buprenorphine.", "severity": 2}
{"drug1": "clozapine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with prazosin.", "severity": 2}
{"drug1": "dantrolene", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with sertraline.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Olopatadine.", "severity": 2}
{"drug1": "promazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Milnacipran.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Cyamemazine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with methoxyflurane.", "severity": 2}
{"drug1": "clomipramine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with phentolamine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with furosemide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with mitoxantrone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Articaine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Lercanidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Agomelatine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with medrysone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with alclometasone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "barnidipine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with metolazone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with prazepam.", "severity": 2}
{"drug1": "phentolamine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with terazosin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with metolazone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with oxprenolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with felodipine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with chlorothiazide.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with citalopram.", "severity": 2}
{"drug1": "butabarbital", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with mepivacaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with zaleplon.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with paramethasone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with budesonide.", "severity": 2}
{"drug1": "dyclonine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with GUANFACINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Telmisartan.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with difluprednate.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with methyldopa.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with chloral hydrate.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Ropivacaine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with bupivacaine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with morphine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with ADAPALENE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with D-mannitol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with Rosuvastatin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with salicylic acid.", "severity": 2}
{"drug1": "Torasemide", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with fosinopril.", "severity": 2}
{"drug1": "codeine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with fluvastatin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with aspirin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with flunitrazepam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with losartan.", "severity": 2}
{"drug1": "Asenapine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with fluocinonide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with indapamide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Tolcapone.", "severity": 2}
{"drug1": "etodolac", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with zaltoprofen.", "severity": 2}
{"drug1": "alclofenac", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Nitroprusside.", "severity": 2}
{"drug1": "alclofenac", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with paramethasone.", "severity": 2}
{"drug1": "temazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "etodolac", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with SERATRODAST.", "severity": 2}
{"drug1": "diltiazem", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with acebutolol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with butalbital.", "severity": 2}
{"drug1": "Trospium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with levorphanol.", "severity": 2}
{"drug1": "enflurane", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with METAXALONE.", "severity": 2}
{"drug1": "methadone", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Lorcaserin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with acetazolamide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Retigabine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with pentazocine.", "severity": 2}
{"drug1": "meperidine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "meperidine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with vigabatrin.", "severity": 2}
{"drug1": "meperidine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with benzocaine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with atenolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with apraclonidine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with tiapride.", "severity": 2}
{"drug1": "quinapril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with methyldopa.", "severity": 2}
{"drug1": "thiamylal", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with DEZOCINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Clevidipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with scopolamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Cevimeline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with nicotine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with hydralazine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with HEROIN.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with nitrous oxide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with lithium ion.", "severity": 2}
{"drug1": "methylene blue", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with PROCATEROL.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Melatonin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with decamethonium.", "severity": 2}
{"drug1": "Tramadol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with brotizolam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Idelalisib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Idelalisib.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with ethotoin.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Riociguat.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Eplerenone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Lorcaserin.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with methazolamide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Agomelatine.", "severity": 2}
{"drug1": "quinapril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ADAPALENE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with nalbuphine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with fluocinonide.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "etodolac", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Icatibant.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with butamben.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with flunarizine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with pyridostigmine.", "severity": 2}
{"drug1": "meclizine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with epirizole.", "severity": 2}
{"drug1": "cetirizine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with scopolamine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "amikacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with amikacin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with oxymorphone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Articaine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with tiapride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with butalbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with clonazepam.", "severity": 2}
{"drug1": "trimipramine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "milrinone", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with Apixaban.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with triflupromazine.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Fosphenytoin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with fludiazepam.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with fenbufen.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Iloperidone.", "severity": 2}
{"drug1": "baclofen", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Iloperidone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Asenapine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Desloratadine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with dopamine.", "severity": 2}
{"drug1": "quazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with procaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with trimipramine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with thiopental.", "severity": 2}
{"drug1": "zopiclone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with procaine.", "severity": 2}
{"drug1": "azelastine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with estrone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Tasimelteon.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with primidone.", "severity": 2}
{"drug1": "codeine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Paliperidone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Pizotifen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Nepafenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with vigabatrin.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with phenytoin.", "severity": 2}
{"drug1": "metaraminol", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with epinephrine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with pilocarpine.", "severity": 2}
{"drug1": "morphine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Fondaparinux", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with Fondaparinux.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with thioridazine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with losartan.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BUPRANOLOL is combined with floctafenine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with diazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with propoxyphene.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with dyclonine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with estrone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Conivaptan.", "severity": 2}
{"drug1": "cerulenin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with nisoldipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "DEXKETOPROFEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with DEXKETOPROFEN.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with clemastine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with butamben.", "severity": 2}
{"drug1": "Olaparib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olaparib is combined with clozapine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "loxapine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with trifluoperazine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with clidinium.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with mepivacaine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with venlafaxine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with isocarboxazid.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with zaleplon.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Desloratadine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Eprosartan.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Perospirone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Ketobemidone.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with duloxetine.", "severity": 2}
{"drug1": "enalapril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with fluoxetine.", "severity": 2}
{"drug1": "enalapril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "morniflumate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with nimesulide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with mepivacaine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Desloratadine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Aceprometazine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with cinoxacin.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with isradipine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Pramocaine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with paroxetine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with MOLINDONE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with primidone.", "severity": 2}
{"drug1": "isradipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with amoxapine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with dantrolene.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Difenoxin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with nortriptyline.", "severity": 2}
{"drug1": "selegiline", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with domperidone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with cyclothiazide.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with butorphanol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Etidocaine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with flunarizine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with MELPERONE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with zotepine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with antipyrine.", "severity": 2}
{"drug1": "prazosin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with felodipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with triprolidine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Pizotifen.", "severity": 2}
{"drug1": "mesalamine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with paramethasone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with methylphenidate.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with methocarbamol.", "severity": 2}
{"drug1": "isradipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with methazolamide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Droxicam.", "severity": 2}
{"drug1": "Butethal", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with meclizine.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Clevidipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with etizolam.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with alclofenac.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Pizotifen.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "trazodone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with maprotiline.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Tolcapone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with vigabatrin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with methylene blue.", "severity": 2}
{"drug1": "clemastine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with oxycodone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Alvimopan.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with felodipine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nisoldipine.", "severity": 2}
{"drug1": "promazine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with procaine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with salicylic acid.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Pramocaine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Propoxycaine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with phenytoin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with homoharringtonine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with brimonidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with gabapentin.", "severity": 2}
{"drug1": "carprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "citric acid", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citric acid is combined with Nintedanib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with felodipine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with enflurane.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "desipramine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Pipamperone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with PROCATEROL.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Nebivolol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Dapagliflozin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with methoxyflurane.", "severity": 2}
{"drug1": "loratadine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Flibanserin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Ketobemidone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with irbesartan.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Pregabalin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with tretinoin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with tranylcypromine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with isoflurane.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Fencamfamin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with thioridazine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with clidinium.", "severity": 2}
{"drug1": "nefazodone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with rasagiline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Udenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vardenafil is combined with Udenafil.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Ketobemidone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Riociguat.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with scopolamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with pramipexole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Escitalopram.", "severity": 2}
{"drug1": "irbesartan", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with meclofenamic acid.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with methyclothiazide.", "severity": 2}
{"drug1": "tropicamide", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with buprenorphine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Agomelatine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Articaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "meprobamate", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with triazolam.", "severity": 2}
{"drug1": "epirizole", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with flunisolide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Pizotifen.", "severity": 2}
{"drug1": "buspirone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with doxepin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Riociguat.", "severity": 2}
{"drug1": "meprobamate", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with dantrolene.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Loxoprofen.", "severity": 2}
{"drug1": "labetalol", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Droxicam.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with tolfenamic acid.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with CLONIXIN.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Clevidipine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with sertraline.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with minoxidil.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Eplerenone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with bupivacaine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with tretinoin.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with suprofen.", "severity": 2}
{"drug1": "methysergide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with felodipine.", "severity": 2}
{"drug1": "linezolid", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Fluspirilene.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with chlormezanone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Escitalopram.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ibuprofen.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Apremilast.", "severity": 2}
{"drug1": "barnidipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with bumetanide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with prilocaine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with quinapril.", "severity": 2}
{"drug1": "barnidipine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with chlorothiazide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "tiagabine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Toloxatone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Pirlindole.", "severity": 2}
{"drug1": "imipramine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with valsartan.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with ILOPROST.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with pilocarpine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Normethadone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with phenytoin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with manidipine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "prednisone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with decamethonium.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Cyamemazine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Lacidipine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Azelnidipine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with paroxetine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with cilnidipine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with zotepine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Iloperidone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Melatonin.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with primidone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with clonazepam.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with pentazocine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with D-mannitol.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with mecamylamine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with loratadine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Salbutamol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with acemetacin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with tioconazole.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Propacetamol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with felbamate.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Olsalazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with clemastine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with norfloxacin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with oxymorphone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with prednisone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ramipril.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with methimazole.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with irinotecan.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Pipotiazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with valsartan.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with brotizolam.", "severity": 2}
{"drug1": "pimozide", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Lormetazepam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with triamterene.", "severity": 2}
{"drug1": "trazodone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with tizanidine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Agomelatine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Perospirone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with equilin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Ketobemidone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with DEZOCINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Pizotifen.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Levetiracetam.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with aspirin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Eprosartan.", "severity": 2}
{"drug1": "difluprednate", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with ambenonium.", "severity": 2}
{"drug1": "procaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with levodopa.", "severity": 2}
{"drug1": "rapamycin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with cilazapril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Lormetazepam.", "severity": 2}
{"drug1": "HEROIN", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Asenapine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Potassium citrate.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Spirapril.", "severity": 2}
{"drug1": "procaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with baclofen.", "severity": 2}
{"drug1": "cilostazol", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with aspirin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with VERAPAMIL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with METAXALONE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Paliperidone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with PAMABROM.", "severity": 2}
{"drug1": "Butethal", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with dantrolene.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Efonidipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with loxapine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Remoxipride.", "severity": 2}
{"drug1": "thiothixene", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with benzocaine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with SERATRODAST.", "severity": 2}
{"drug1": "thiothixene", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with vigabatrin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Aceclofenac.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with zaltoprofen.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "procaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "pravastatin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pravastatin is combined with paroxetine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "methylergonovine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with methylergonovine.", "severity": 2}
{"drug1": "procaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with oxprenolol.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with metoclopramide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with ropinirole.", "severity": 2}
{"drug1": "butabarbital", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with MELPERONE.", "severity": 2}
{"drug1": "procaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with prazepam.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Aliskiren.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with mefloquine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with meclizine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Salbutamol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with GUANFACINE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with glutethimide.", "severity": 2}
{"drug1": "pramipexole", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with chlorthalidone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with clemastine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Butethal.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with methylprednisolone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Rotigotine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with ritodrine.", "severity": 2}
{"drug1": "atenolol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with D-mannitol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with hydralazine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with doxepin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "proparacaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Pipamperone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with droperidol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Oxetacaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with KETAZOLAM.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with hydralazine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with protriptyline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with nabumetone.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with cetirizine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chlorothiazide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with betamethasone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "PAMIDRONIC ACID", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PAMIDRONIC ACID is combined with Deferasirox.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with amisulpride.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with DESFLURANE.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Pitavastatin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Tixocortol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Levetiracetam.", "severity": 2}
{"drug1": "bumetanide", "drug2": "gentamicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with gentamicin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Tasimelteon.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Tapentadol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Vilanterol.", "severity": 2}
{"drug1": "propranolol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with nadolol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with OLODATEROL.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "thiothixene", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with felodipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with carisoprodol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Paliperidone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with sulpiride.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with clenbuterol.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with methadone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Retigabine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with spironolactone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with propranolol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with fleroxacin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with fexofenadine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with sertraline.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Pentolinium.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with pimozide.", "severity": 2}
{"drug1": "triamterene", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with captopril.", "severity": 2}
{"drug1": "methadone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Pizotifen.", "severity": 2}
{"drug1": "bepridil", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with papaverine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with dantrolene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with trifluoperazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Flibanserin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with enalapril.", "severity": 2}
{"drug1": "clorazepate", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with trazodone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Tasimelteon.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Lormetazepam.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "propofol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with DEZOCINE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "ceftriaxone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with ceftriaxone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Ciclesonide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Pipamperone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with ethotoin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Aceprometazine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with butalbital.", "severity": 2}
{"drug1": "Trametinib", "drug2": "Dabrafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trametinib is combined with Dabrafenib.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Deferasirox.", "severity": 2}
{"drug1": "dibucaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with dantrolene.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Nebivolol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Clofarabine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with maprotiline.", "severity": 2}
{"drug1": "carprofen", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with antipyrine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Nebivolol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with MELPERONE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "melphalan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when melphalan is combined with clozapine.", "severity": 2}
{"drug1": "doxylamine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "brotizolam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Mometasone.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Ramelteon.", "severity": 2}
{"drug1": "apomorphine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nimesulide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nitric oxide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Temsirolimus.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "bepridil", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with atorvastatin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with vigabatrin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Halobetasol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with pyridostigmine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sunitinib is combined with leflunomide.", "severity": 2}
{"drug1": "risperidone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with METAXALONE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with estrone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with formestane.", "severity": 2}
{"drug1": "salicylamide", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with methylprednisolone.", "severity": 2}
{"drug1": "procyclidine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with hydromorphone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with ADAPALENE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with thiamylal.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiamylal", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with penbutolol.", "severity": 2}
{"drug1": "temazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with topiramate.", "severity": 2}
{"drug1": "halothane", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ximelagatran is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with efavirenz.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with diflunisal.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Agomelatine.", "severity": 2}
{"drug1": "doxepin", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with propofol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with metolazone.", "severity": 2}
{"drug1": "doxepin", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with isoproterenol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Paliperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Lenalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Lenalidomide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with papaverine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Etidocaine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with tiapride.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Perospirone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Levetiracetam.", "severity": 2}
{"drug1": "reserpine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Fospropofol.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with tiapride.", "severity": 2}
{"drug1": "cocaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Pipamperone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with methyldopa.", "severity": 2}
{"drug1": "secobarbital", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with mesoridazine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Cyamemazine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with fexofenadine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with nitrendipine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Tasimelteon.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Vilanterol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Levocetirizine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "RUCAPARIB", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with RUCAPARIB.", "severity": 2}
{"drug1": "metoprolol", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with isradipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Ciclesonide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Olmesartan.", "severity": 2}
{"drug1": "glutethimide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with efavirenz.", "severity": 2}
{"drug1": "fenbufen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with epirizole.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Desloratadine.", "severity": 2}
{"drug1": "triazolam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with bromazepam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with mepivacaine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with budesonide.", "severity": 2}
{"drug1": "propantheline", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with nalbuphine.", "severity": 2}
{"drug1": "loxapine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with chlormezanone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with azelastine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Tasimelteon.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Trospium", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with tolterodine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Icatibant.", "severity": 2}
{"drug1": "azelastine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with flunisolide.", "severity": 2}
{"drug1": "loxapine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Icatibant.", "severity": 2}
{"drug1": "triprolidine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with primidone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with dipyridamole.", "severity": 2}
{"drug1": "valsartan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with quetiapine.", "severity": 2}
{"drug1": "citalopram", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with reserpine.", "severity": 2}
{"drug1": "loxapine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with enflurane.", "severity": 2}
{"drug1": "triazolam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "triazolam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with flunitrazepam.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with betamethasone.", "severity": 2}
{"drug1": "sotalol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Eprosartan.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with meclizine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Pipamperone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Tianeptine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Articaine.", "severity": 2}
{"drug1": "5-azacytidine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-azacytidine is combined with clozapine.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Benidipine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Retigabine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Canagliflozin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with OLODATEROL.", "severity": 2}
{"drug1": "bifonazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with nilvadipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with alclofenac.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with fluvoxamine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "haloprogin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with xylometazoline.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Flupentixol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ramipril.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with carisoprodol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with terbutaline.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Empagliflozin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "pergolide", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with loratadine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Normethadone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Lurasidone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Halobetasol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with risperidone.", "severity": 2}
{"drug1": "pergolide", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with clindamycin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with meclizine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with chlorothiazide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with quinapril.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Retigabine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with fluoxetine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with oxprenolol.", "severity": 2}
{"drug1": "proparacaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with loratadine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with efavirenz.", "severity": 2}
{"drug1": "indapamide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with hydralazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with benzocaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with vigabatrin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with amisulpride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ILOPROST.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with ethotoin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with loratadine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Fluprednidene.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with imipramine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with brotizolam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Difenoxin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Agomelatine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Pipamperone.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Retigabine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with nalbuphine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with prochlorperazine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "prazosin", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with quetiapine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with imipramine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Riociguat.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with dihydroergotamine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with loratadine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with ethosuximide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Pipamperone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with AMILORIDE.", "severity": 2}
{"drug1": "triazolam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Pipotiazine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with prochlorperazine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with amcinonide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with prochlorperazine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with diltiazem.", "severity": 2}
{"drug1": "isoflurane", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with cetirizine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with primidone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with protriptyline.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Iloperidone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Ciclesonide.", "severity": 2}
{"drug1": "isradipine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Nebivolol.", "severity": 2}
{"drug1": "biperiden", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Atracurium besylate.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with thiothixene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with tetracaine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with amitriptyline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Tolcapone.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with eperisone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with methocarbamol.", "severity": 2}
{"drug1": "trazodone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with zonisamide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with triprolidine.", "severity": 2}
{"drug1": "pimozide", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with CYCLIZINE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Ciclesonide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "quinapril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ZILEUTON.", "severity": 2}
{"drug1": "quinapril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with etodolac.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "propranolol", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with nicardipine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with clomipramine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with triamterene.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with butalbital.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Risedronic acid.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Articaine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with tiapride.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with cetirizine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with duloxetine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Isoflurophate.", "severity": 2}
{"drug1": "halcinonide", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with galanthamine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Etidocaine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with GUANFACINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Normethadone.", "severity": 2}
{"drug1": "Articaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with nefazodone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Etoricoxib.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with HYDROCODONE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with methadone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with halothane.", "severity": 2}
{"drug1": "estazolam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with tiapride.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with efavirenz.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with felodipine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Tofacitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Tofacitinib.", "severity": 2}
{"drug1": "pergolide", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with manidipine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Lercanidipine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with clonidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with quinapril.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with bumetanide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with trifluoperazine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with maprotiline.", "severity": 2}
{"drug1": "dibucaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with mesoridazine.", "severity": 2}
{"drug1": "morphine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with quazepam.", "severity": 2}
{"drug1": "propofol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with doxepin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Eplerenone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Normethadone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with zonisamide.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with methazolamide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with captopril.", "severity": 2}
{"drug1": "barnidipine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with thalidomide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Etomidate.", "severity": 2}
{"drug1": "propofol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with fludiazepam.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with acebutolol.", "severity": 2}
{"drug1": "loratadine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with promethazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Ropivacaine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with bupivacaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with dipyridamole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with desipramine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Paliperidone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with sertraline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with nylidrin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Tasimelteon.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with furosemide.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with paroxetine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with tizanidine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with baclofen.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with halcinonide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with ondansetron.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with levodopa.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Clobetasone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with METAXALONE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with zonisamide.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Calcium acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with Calcium acetate.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with primidone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with DESONIDE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetrahydrozoline is combined with isoxsuprine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with propranolol.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with citalopram.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with zaltoprofen.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Aceclofenac.", "severity": 2}
{"drug1": "gabapentin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with GUANFACINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with paroxetine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with prazepam.", "severity": 2}
{"drug1": "methysergide", "drug2": "Idelalisib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Idelalisib.", "severity": 2}
{"drug1": "buspirone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with loratadine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with prazepam.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nilvadipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with VERAPAMIL.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with METAXALONE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with cocaine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with tiagabine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with ondansetron.", "severity": 2}
{"drug1": "labetalol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with metoprolol.", "severity": 2}
{"drug1": "eperisone", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with sertraline.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with prilocaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with tranylcypromine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with ethotoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with zaleplon.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with oxycodone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Melatonin.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Propiverine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Salbutamol.", "severity": 2}
{"drug1": "carprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with loteprednol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Propacetamol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with promethazine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with chlorthalidone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with methocarbamol.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Levetiracetam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with triprolidine.", "severity": 2}
{"drug1": "enflurane", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with phenytoin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with antipyrine.", "severity": 2}
{"drug1": "propofol", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with atenolol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Cis-mdp.", "severity": 2}
{"drug1": "benzocaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with butalbital.", "severity": 2}
{"drug1": "timolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Riociguat.", "severity": 2}
{"drug1": "prazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Perospirone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with chlorprothixene.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with tetracaine.", "severity": 2}
{"drug1": "propofol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Aliskiren.", "severity": 2}
{"drug1": "loteprednol", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with sparfloxacin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with histamine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "celecoxib", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with betamethasone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with butamben.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Flibanserin.", "severity": 2}
{"drug1": "propranolol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with irbesartan.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with simvastatin.", "severity": 2}
{"drug1": "propranolol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with felodipine.", "severity": 2}
{"drug1": "propranolol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Lorcaserin.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Normethadone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with bupropion.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "alprazolam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with tiagabine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Pramocaine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with tiapride.", "severity": 2}
{"drug1": "clozapine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with benzocaine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "methotrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with methotrexate.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Pizotifen.", "severity": 2}
{"drug1": "nicergoline", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with diazepam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "clozapine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with butalbital.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Remoxipride.", "severity": 2}
{"drug1": "topiramate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with desipramine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Tadalafil.", "severity": 2}
{"drug1": "clozapine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ILOPROST.", "severity": 2}
{"drug1": "nicergoline", "drug2": "pergolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with pergolide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Eprosartan.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with quetiapine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Conivaptan.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with clonazepam.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with promethazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with mepivacaine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with sertraline.", "severity": 2}
{"drug1": "thiothixene", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with clomipramine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with desipramine.", "severity": 2}
{"drug1": "clozapine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with dipyridamole.", "severity": 2}
{"drug1": "meperidine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with lidocaine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "tolmetin", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with loteprednol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with metoclopramide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with suprofen.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with doxepin.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with atorvastatin.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Calcium acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with Calcium acetate.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with donepezil.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nilvadipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Articaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with clonazepam.", "severity": 2}
{"drug1": "Articaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with promethazine.", "severity": 2}
{"drug1": "sertraline", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with tiapride.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Indacaterol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with enalapril.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with SERATRODAST.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with tofisopam.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "triamterene", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Eprosartan.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with etizolam.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Demecarium.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with benzocaine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Cevimeline.", "severity": 2}
{"drug1": "atenolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with nicotine.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with Tasimelteon.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with penbutolol.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with cilnidipine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with dipyridamole.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with oxaprozin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with maprotiline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with zaleplon.", "severity": 2}
{"drug1": "brimonidine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pravastatin is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Desloratadine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with nimesulide.", "severity": 2}
{"drug1": "Trospium", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "midazolam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with oxprenolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Olopatadine.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with triamterene.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with irbesartan.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with felodipine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with chlorothiazide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Levocetirizine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Nebivolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Olsalazine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with amisulpride.", "severity": 2}
{"drug1": "valsartan", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "trazodone", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Vilazodone.", "severity": 2}
{"drug1": "codeine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with GUANFACINE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Teriflunomide.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with orphenadrine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with prazepam.", "severity": 2}
{"drug1": "procarbazine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with isocarboxazid.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with dexamethasone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with clomipramine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with meclizine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with spironolactone.", "severity": 2}
{"drug1": "THYMOL", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with VERAPAMIL.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Escitalopram.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Isometheptene.", "severity": 2}
{"drug1": "meprobamate", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with chlormezanone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with atorvastatin.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with promethazine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with gabapentin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Propoxycaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with clonidine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with thioridazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Pramocaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with levodopa.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with felodipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Uramustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Uramustine.", "severity": 2}
{"drug1": "Metixene", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with clonazepam.", "severity": 2}
{"drug1": "quazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "quazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with benzocaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with ethotoin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with felbamate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Oxetacaine.", "severity": 2}
{"drug1": "bupropion", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupropion is combined with fluvoxamine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Mirabegron.", "severity": 2}
{"drug1": "rapamycin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with fosinopril.", "severity": 2}
{"drug1": "bifonazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with dextromethorphan.", "severity": 2}
{"drug1": "Asenapine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with GUANFACINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Apremilast.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Articaine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "TEMOPORFIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with TEMOPORFIN.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Dothiepin.", "severity": 2}
{"drug1": "bumetanide", "drug2": "metrizamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with metrizamide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Etidocaine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Naftifine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with Eplerenone.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with Dapagliflozin.", "severity": 2}
{"drug1": "brimonidine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with methazolamide.", "severity": 2}
{"drug1": "propofol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Fluspirilene.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Aliskiren.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with tiapride.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Amrinone.", "severity": 2}
{"drug1": "carprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with difluprednate.", "severity": 2}
{"drug1": "amcinonide", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with fleroxacin.", "severity": 2}
{"drug1": "reserpine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with methadone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with MELPERONE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with zotepine.", "severity": 2}
{"drug1": "zotepine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with isoxsuprine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with trifluoperazine.", "severity": 2}
{"drug1": "clidinium", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with levodopa.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with topiramate.", "severity": 2}
{"drug1": "Artemether", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with barnidipine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "suprofen", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with mycophenolic acid.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Levetiracetam.", "severity": 2}
{"drug1": "sotalol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Normethadone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Lurasidone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Difenoxin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with proparacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Halazepam.", "severity": 2}
{"drug1": "clemastine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with ethotoin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Normethadone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Propacetamol.", "severity": 2}
{"drug1": "quazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with levodopa.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with tiagabine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with nalbuphine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with oxazepam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with triprolidine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with methocarbamol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with methylphenidate.", "severity": 2}
{"drug1": "Butethal", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Pomalidomide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with HEROIN.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with flumethasone.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with hydromorphone.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "buspirone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with triprolidine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with medrysone.", "severity": 2}
{"drug1": "buspirone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with methocarbamol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Empagliflozin.", "severity": 2}
{"drug1": "pimozide", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Etidocaine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with hydralazine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with triflupromazine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Abemaciclib.", "severity": 2}
{"drug1": "HEROIN", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with polythiazide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Etomidate", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with nefazodone.", "severity": 2}
{"drug1": "methadone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Pipamperone.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with pravastatin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with dexamethasone.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Perospirone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Fospropofol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nadolol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with moclobemide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with CLONIXIN.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with METAXALONE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with triflupromazine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Iloperidone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ibuprofen.", "severity": 2}
{"drug1": "levorphanol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with furosemide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Lormetazepam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with tizanidine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "SAQUINAVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "phenazopyridine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenazopyridine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "reserpine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Perospirone.", "severity": 2}
{"drug1": "sotalol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with chlorothiazide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with diflunisal.", "severity": 2}
{"drug1": "perphenazine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with protriptyline.", "severity": 2}
{"drug1": "perphenazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with cetirizine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with nimesulide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with haloperidol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Levocetirizine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with alclofenac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with tiapride.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "loratadine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with felbamate.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with gabapentin.", "severity": 2}
{"drug1": "butalbital", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with sertraline.", "severity": 2}
{"drug1": "lisinopril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with meperidine.", "severity": 2}
{"drug1": "suprofen", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with antipyrine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with isoxsuprine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "dacarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with dacarbazine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "temozolomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with temozolomide.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Levocetirizine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with Ethylmorphine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with diphenhydramine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Sitaxsentan.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with meclizine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with tizanidine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ceritinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ceritinib.", "severity": 2}
{"drug1": "flumethasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with enoxacin.", "severity": 2}
{"drug1": "ethanol", "drug2": "Eluxadoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Eluxadoline.", "severity": 2}
{"drug1": "moclobemide", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with bezafibrate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "risperidone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Fluspirilene.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with barnidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with DESFLURANE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Tramadol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Droxicam.", "severity": 2}
{"drug1": "busulfan", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when busulfan is combined with ifosfamide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with methylprednisolone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Cyamemazine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Tasimelteon.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with methocarbamol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with spironolactone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with triprolidine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with papaverine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with theobromine.", "severity": 2}
{"drug1": "nadolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with acetylcholine.", "severity": 2}
{"drug1": "baclofen", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Fosphenytoin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with bromocriptine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Vilanterol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with primidone.", "severity": 2}
{"drug1": "zotepine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "zotepine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Ramelteon.", "severity": 2}
{"drug1": "pimozide", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with nimesulide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with formestane.", "severity": 2}
{"drug1": "leflunomide", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with salicylamide.", "severity": 2}
{"drug1": "morphine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with HEROIN.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with triamcinolone.", "severity": 2}
{"drug1": "imipramine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nisoldipine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with alclometasone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with nitric oxide.", "severity": 2}
{"drug1": "tolazoline", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with triamterene.", "severity": 2}
{"drug1": "procyclidine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with quinidine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Pizotifen.", "severity": 2}
{"drug1": "risperidone", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with nalbuphine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Mephobarbital.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with trimipramine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Pinaverium.", "severity": 2}
{"drug1": "Perampanel", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with citalopram.", "severity": 2}
{"drug1": "triamterene", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with tizanidine.", "severity": 2}
{"drug1": "trazodone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "triamterene", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with acetazolamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Fluspirilene.", "severity": 2}
{"drug1": "imipramine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with penbutolol.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Salsalate.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with doxorubicin.", "severity": 2}
{"drug1": "metolazone", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with BISOPROLOL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Retigabine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with clozapine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with etodolac.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Metixene.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "risperidone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with thiopental.", "severity": 2}
{"drug1": "trandolapril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "risperidone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with ethosuximide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Halazepam.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with aspirin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with benzyl alcohol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with selegiline.", "severity": 2}
{"drug1": "clidinium", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Pizotifen.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with perphenazine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with eperisone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with vinorelbine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with risperidone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with imipramine.", "severity": 2}
{"drug1": "ethanol", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with nefazodone.", "severity": 2}
{"drug1": "bepridil", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Nabilone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with prazepam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "bepridil", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with sotalol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Articaine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with loratadine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Propacetamol.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with formoterol.", "severity": 2}
{"drug1": "trazodone", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with methadone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Normethadone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with terazosin.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with BISOPROLOL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with nisoldipine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with salicylamide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with promethazine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "cocaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with fexofenadine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Desloratadine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with butalbital.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with mepivacaine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with DESFLURANE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with valsartan.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with quazepam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with dantrolene.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with amitriptyline.", "severity": 2}
{"drug1": "oxycodone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with sulpiride.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with Ephedrine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with carisoprodol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with methyclothiazide.", "severity": 2}
{"drug1": "carprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "Bretylium", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with terazosin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with felodipine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with irbesartan.", "severity": 2}
{"drug1": "selegiline", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Perospirone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with ritodrine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with sotalol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with lithium ion.", "severity": 2}
{"drug1": "polythiazide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with digitoxin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with dipyridamole.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Riociguat.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with epirizole.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with MELPERONE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with fluocinonide.", "severity": 2}
{"drug1": "sulconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with eperisone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with cetirizine.", "severity": 2}
{"drug1": "loxapine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with levorphanol.", "severity": 2}
{"drug1": "risperidone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with atorvastatin.", "severity": 2}
{"drug1": "loxapine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with perphenazine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Eprosartan.", "severity": 2}
{"drug1": "Normethadone", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with theobromine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with dantrolene.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Canagliflozin.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with acebutolol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with SERATRODAST.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with captopril.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Difenoxin.", "severity": 2}
{"drug1": "papaverine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Canagliflozin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with meperidine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with nicardipine.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "CAPECITABINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levoleucovorin is combined with CAPECITABINE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with pentazocine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Levobupivacaine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with citalopram.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with enalapril.", "severity": 2}
{"drug1": "selegiline", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with sertraline.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "midazolam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with amoxapine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with cinnarizine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with isradipine.", "severity": 2}
{"drug1": "propofol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with felbamate.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with topiramate.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with tiagabine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with etizolam.", "severity": 2}
{"drug1": "propantheline", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with orphenadrine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Droxicam.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with clonidine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when galanthamine is combined with acetylcholine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "linezolid", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with rizatriptan.", "severity": 2}
{"drug1": "morniflumate", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with NAPROXEN.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with brotizolam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with phenytoin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Flibanserin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Pipotiazine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with mefenamic acid.", "severity": 2}
{"drug1": "acemetacin", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with paramethasone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with meclizine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Eprosartan.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Mephobarbital.", "severity": 2}
{"drug1": "zaleplon", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with meclizine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Arformoterol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with pentazocine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with desipramine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with felbamate.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with clenbuterol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Dothiepin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with benazepril.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Aliskiren.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with nortriptyline.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Fluprednidene.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with medrysone.", "severity": 2}
{"drug1": "Trospium", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with orphenadrine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with GUANFACINE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "Apremilast", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with equilin.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with penbutolol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with methylphenidate.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with methocarbamol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with nalidixic acid.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with triprolidine.", "severity": 2}
{"drug1": "SULFADOXINE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SULFADOXINE is combined with mecamylamine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with propoxyphene.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Riociguat.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magaldrate is combined with misoprostol.", "severity": 2}
{"drug1": "meperidine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with HEROIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with prazepam.", "severity": 2}
{"drug1": "sulindac", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with teniposide.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with nicardipine.", "severity": 2}
{"drug1": "zotepine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Pizotifen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "gemcitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with gemcitabine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with nortriptyline.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with amoxapine.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mitoxantrone is combined with clozapine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with glutethimide.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with tiapride.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with GUANFACINE.", "severity": 2}
{"drug1": "methysergide", "drug2": "pergolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with pergolide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Articaine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Pipamperone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with floctafenine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with prazosin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Ketobemidone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with cinoxacin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with dipyridamole.", "severity": 2}
{"drug1": "codeine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with selegiline.", "severity": 2}
{"drug1": "acemetacin", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "trandolapril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "triazolam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with prilocaine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with GUANFACINE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with nitrendipine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Iloperidone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Difenoxin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with olanzapine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with MOLINDONE.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ZILEUTON.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Aliskiren.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Aceprometazine.", "severity": 2}
{"drug1": "practolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when practolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Delavirdine is combined with oxycodone.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with duloxetine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "netilmicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with netilmicin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with MOLINDONE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with thiothixene.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with promazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Aceprometazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Sorafenib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with DESONIDE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Levetiracetam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with amisulpride.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Levocetirizine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with protriptyline.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with methadone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with diltiazem.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with celiprolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with cetirizine.", "severity": 2}
{"drug1": "propofol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Asenapine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "norepinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with norepinephrine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "felodipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with papaverine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with flurandrenolide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with clidinium.", "severity": 2}
{"drug1": "oxycodone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with diazepam.", "severity": 2}
{"drug1": "topiramate", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with ethosuximide.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with sulpiride.", "severity": 2}
{"drug1": "butabarbital", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with nefazodone.", "severity": 2}
{"drug1": "thiopental", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with chlormezanone.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Pinaverium.", "severity": 2}
{"drug1": "prazosin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Escitalopram.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Fospropofol.", "severity": 2}
{"drug1": "meclizine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with felbamate.", "severity": 2}
{"drug1": "doxazosin", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with D-mannitol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with indapamide.", "severity": 2}
{"drug1": "codeine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with cetirizine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Halazepam.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with methazolamide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with proparacaine.", "severity": 2}
{"drug1": "prazosin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with benazepril.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ADAPALENE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with sulpiride.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with NAPROXEN.", "severity": 2}
{"drug1": "selegiline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with isoproterenol.", "severity": 2}
{"drug1": "selegiline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with felbamate.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with levorphanol.", "severity": 2}
{"drug1": "selegiline", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with promethazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with SERATRODAST.", "severity": 2}
{"drug1": "clorazepate", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with maprotiline.", "severity": 2}
{"drug1": "clorazepate", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with mesoridazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with lidocaine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with formestane.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with penbutolol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Butethal.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with mycophenolic acid.", "severity": 2}
{"drug1": "difluprednate", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with physostigmine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with tetracaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with benzocaine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with rivastigmine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with cinoxacin.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with gabapentin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with terazosin.", "severity": 2}
{"drug1": "biperiden", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with pirenzepine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with Milnacipran.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with dopamine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with fosinopril.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with fluvoxamine.", "severity": 2}
{"drug1": "azelastine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with acemetacin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Bretylium.", "severity": 2}
{"drug1": "dyclonine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with vigabatrin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with tubocurarine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olaparib is combined with oxycodone.", "severity": 2}
{"drug1": "ramipril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with leflunomide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with triprolidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with thiamylal.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Demecarium is combined with Carbamylcholine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Remoxipride.", "severity": 2}
{"drug1": "diclofenac", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with leflunomide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with GUANFACINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Nitroprusside.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with tetracaine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Lapatinib.", "severity": 2}
{"drug1": "ramipril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with indomethacin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with topiramate.", "severity": 2}
{"drug1": "buspirone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with efavirenz.", "severity": 2}
{"drug1": "carprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Pomalidomide.", "severity": 2}
{"drug1": "buspirone", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with nitroglycerin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Etidronic acid.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Pramocaine.", "severity": 2}
{"drug1": "captopril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with flurbiprofen.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with sevoflurane.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Imatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Imatinib.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Normethadone.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with morphine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Lornoxicam.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with nicotine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Cevimeline.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Phenelzine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "amiodarone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with AMILORIDE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with formoterol.", "severity": 2}
{"drug1": "terconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with barnidipine.", "severity": 2}
{"drug1": "etodolac", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with clemastine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Olmesartan.", "severity": 2}
{"drug1": "buspirone", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Frovatriptan.", "severity": 2}
{"drug1": "buspirone", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with gabapentin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with thiamylal.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with desipramine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with butamben.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Trospium", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Desloratadine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Iloperidone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with acemetacin.", "severity": 2}
{"drug1": "halothane", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with clonazepam.", "severity": 2}
{"drug1": "halothane", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with promethazine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with homoharringtonine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Milnacipran.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyzine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "efavirenz", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with promethazine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with phenytoin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with methylprednisolone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Conivaptan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with halothane.", "severity": 2}
{"drug1": "estazolam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with procaine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Tolcapone.", "severity": 2}
{"drug1": "felbamate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Tasimelteon.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with amitriptyline.", "severity": 2}
{"drug1": "midazolam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with butamben.", "severity": 2}
{"drug1": "estazolam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with trimipramine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with etizolam.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Nintedanib.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Lenvatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Lenvatinib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with felodipine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with hydrocortisone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "tibolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with tibolone.", "severity": 2}
{"drug1": "prazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Olaparib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Olaparib.", "severity": 2}
{"drug1": "thiothixene", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with brotizolam.", "severity": 2}
{"drug1": "pancuronium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with HEROIN.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Pomalidomide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with MOXONIDINE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with DEZOCINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with methyldopa.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Levomilnacipran.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "pentazocine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with maprotiline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pipotiazine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with carisoprodol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with mesoridazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with METAXALONE.", "severity": 2}
{"drug1": "quinapril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "thiopental", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with meclizine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with trimipramine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with D-mannitol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with fenoprofen.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with leflunomide.", "severity": 2}
{"drug1": "diazepam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with diphenhydramine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Clevidipine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with DEZOCINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Escitalopram.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Levetiracetam.", "severity": 2}
{"drug1": "butalbital", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Ramelteon.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with propoxyphene.", "severity": 2}
{"drug1": "Melatonin", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with prazepam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with thiamylal.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Pipamperone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Pizotifen.", "severity": 2}
{"drug1": "enflurane", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with chlorzoxazone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nitroglycerin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with lisinopril.", "severity": 2}
{"drug1": "ipratropium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with meperidine.", "severity": 2}
{"drug1": "halothane", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with atenolol.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with felodipine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with nabumetone.", "severity": 2}
{"drug1": "codeine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Melatonin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with homoharringtonine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with ketorolac.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with fexofenadine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with tenoxicam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Asenapine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with triprolidine.", "severity": 2}
{"drug1": "amifostine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with terazosin.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with nortriptyline.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with alclofenac.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Clevidipine.", "severity": 2}
{"drug1": "amifostine", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with arsenic trioxide.", "severity": 2}
{"drug1": "buspirone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with propoxyphene.", "severity": 2}
{"drug1": "quinapril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with salicylic acid.", "severity": 2}
{"drug1": "zaleplon", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with dantrolene.", "severity": 2}
{"drug1": "buspirone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with dyclonine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with quetiapine.", "severity": 2}
{"drug1": "morphine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "morphine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with carvedilol.", "severity": 2}
{"drug1": "morphine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with MOLINDONE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with hydralazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Cladribine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Cladribine.", "severity": 2}
{"drug1": "valsartan", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with alclofenac.", "severity": 2}
{"drug1": "meperidine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with clomipramine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with donepezil.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Salbutamol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with doxepin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with nisoldipine.", "severity": 2}
{"drug1": "topiramate", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with zonisamide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with acemetacin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with propranolol.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Mometasone.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with hydrocortisone.", "severity": 2}
{"drug1": "procaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Perospirone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Treprostinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rosiglitazone is combined with Treprostinil.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Olsalazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Etidocaine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with clofazimine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with clomipramine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "epinephrine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Perospirone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with dichlorphenamide.", "severity": 2}
{"drug1": "nadolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "isradipine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with benazepril.", "severity": 2}
{"drug1": "HEROIN", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with furazolidone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with phentolamine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Pimecrolimus.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with furosemide.", "severity": 2}
{"drug1": "pergolide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with sertraline.", "severity": 2}
{"drug1": "tolmetin", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with triamcinolone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with clidinium.", "severity": 2}
{"drug1": "pergolide", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with pimozide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with pravastatin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with quetiapine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with ketamine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with flurandrenolide.", "severity": 2}
{"drug1": "terconazole", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with simvastatin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Lercanidipine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with metolazone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with CARTEOLOL.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Pipotiazine.", "severity": 2}
{"drug1": "atenolol", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with nimodipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with methazolamide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with nitric oxide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with pargyline.", "severity": 2}
{"drug1": "Micafungin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with nitrendipine.", "severity": 2}
{"drug1": "methadone", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with sumatriptan.", "severity": 2}
{"drug1": "proparacaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with HEROIN.", "severity": 2}
{"drug1": "Asenapine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with clonidine.", "severity": 2}
{"drug1": "methadone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with METAXALONE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with nitroglycerin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with equilin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with dichlorphenamide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with clonidine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with maprotiline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with equilin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with ethosuximide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with meclofenamic acid.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "nimodipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with salicylic acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Pizotifen.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Zoledronic acid.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with felodipine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with benazepril.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with D-mannitol.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with chlorthalidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Alitretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Alitretinoin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with antipyrine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Desloratadine.", "severity": 2}
{"drug1": "ethanol", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with aspirin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with estrone.", "severity": 2}
{"drug1": "tetracaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with efavirenz.", "severity": 2}
{"drug1": "tizanidine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with clonazepam.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with metoprolol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with trandolapril.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Nebivolol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Pipamperone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Levetiracetam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nadolol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with DEZOCINE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with clidinium.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Desloratadine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with cinoxacin.", "severity": 2}
{"drug1": "reserpine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with propofol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with barnidipine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Lapatinib.", "severity": 2}
{"drug1": "codeine", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Drospirenone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with trandolapril.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Deferasirox.", "severity": 2}
{"drug1": "procarbazine", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with prochlorperazine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Etidronic acid.", "severity": 2}
{"drug1": "clonidine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with nitroglycerin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with betaxolol.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with metoclopramide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Asenapine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with cocaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with chlorpheniramine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with reserpine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with NAPROXEN.", "severity": 2}
{"drug1": "nifedipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with METAXALONE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Pipamperone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with ambenonium.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with HEROIN.", "severity": 2}
{"drug1": "resveratrol", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with flurandrenolide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with mefenamic acid.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Fluprednidene.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "triazolam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Pizotifen.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Idelalisib is combined with Abemaciclib.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with tretinoin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with tranylcypromine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with isoflurane.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Lurasidone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Normethadone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with levorphanol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Icatibant.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with buprenorphine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with meperidine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with pyridostigmine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with methazolamide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with amisulpride.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Eplerenone.", "severity": 2}
{"drug1": "loxapine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Difenoxin.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Isotretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with Isotretinoin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with butalbital.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with trimipramine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with homoharringtonine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with thalidomide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with metaproterenol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with procaine.", "severity": 2}
{"drug1": "trazodone", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with dextromethorphan.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "hydroxyurea", "drug2": "didanosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyurea is combined with didanosine.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcifediol is combined with ergocalciferol.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with nimesulide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Deferasirox.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Pramocaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Propoxycaine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Clobetasone.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "etizolam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with desipramine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Rotigotine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with isoxsuprine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with sertraline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with linezolid.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with fexofenadine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with NITROUS ACID.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Salbutamol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with zaleplon.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Fencamfamin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with chlorprothixene.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with sertraline.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nimesulide", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with zaltoprofen.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Flibanserin.", "severity": 2}
{"drug1": "terconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with diltiazem.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with halcinonide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with difluprednate.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Difenoxin.", "severity": 2}
{"drug1": "clozapine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with dyclonine.", "severity": 2}
{"drug1": "L-phenylalanine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when L-phenylalanine is combined with clozapine.", "severity": 2}
{"drug1": "promethazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with thiopental.", "severity": 2}
{"drug1": "topiramate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with nortriptyline.", "severity": 2}
{"drug1": "isoflurane", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "morphine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "triazolam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with bromazepam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with cetirizine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with butamben.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with protriptyline.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with metoclopramide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with sotalol.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Aripiprazole.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with chlorprothixene.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with metoclopramide.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with oxycodone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with perphenazine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Riociguat.", "severity": 2}
{"drug1": "brotizolam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with duloxetine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with tizanidine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with alclometasone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Varenicline.", "severity": 2}
{"drug1": "clidinium", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Difenoxin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with cetirizine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with nitrazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with ketamine.", "severity": 2}
{"drug1": "Butethal", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with butalbital.", "severity": 2}
{"drug1": "flurazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with protriptyline.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with quetiapine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with felbamate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with paramethasone.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with Apixaban.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with bromazepam.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with meperidine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Butethal.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Levetiracetam.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with olanzapine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Difenoxin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with lithium ion.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with clorazepate.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Naftifine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Agomelatine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Etidocaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Aripiprazole.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with D-mannitol.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with imipramine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with vigabatrin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "clozapine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with tetracaine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Eprosartan.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with ibuprofen.", "severity": 2}
{"drug1": "etizolam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "procaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with SERTINDOLE.", "severity": 2}
{"drug1": "procaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Enalaprilat.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Oxetacaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with triflupromazine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with baclofen.", "severity": 2}
{"drug1": "phentolamine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with propofol.", "severity": 2}
{"drug1": "triazolam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with butalbital.", "severity": 2}
{"drug1": "haloperidol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with GUANFACINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with furosemide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Lornoxicam.", "severity": 2}
{"drug1": "ramipril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Olsalazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "diflorasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with clidinium.", "severity": 2}
{"drug1": "pramipexole", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with indapamide.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Prasugrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Prasugrel.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with benzphetamine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with ritodrine.", "severity": 2}
{"drug1": "butenafine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Risedronic acid.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Risedronic acid.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with pargyline.", "severity": 2}
{"drug1": "triprolidine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with nefazodone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with thiothixene.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "triprolidine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with doxepin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Mometasone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Aceclofenac.", "severity": 2}
{"drug1": "codeine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "codeine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with triazolam.", "severity": 2}
{"drug1": "codeine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "pentazocine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with fexofenadine.", "severity": 2}
{"drug1": "benztropine", "drug2": "ATROPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with ATROPINE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with medrysone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with loteprednol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with nylidrin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "butenafine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with eperisone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with enalapril.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Difenoxin.", "severity": 2}
{"drug1": "equilin", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Abemaciclib.", "severity": 2}
{"drug1": "triamterene", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with penbutolol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with terazosin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Butethal.", "severity": 2}
{"drug1": "miconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with nicardipine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with chlorpheniramine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with bromocriptine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with trimipramine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with isoxsuprine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Melatonin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with prazosin.", "severity": 2}
{"drug1": "labetalol", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with dopamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with clonazepam.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with promethazine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with tolterodine.", "severity": 2}
{"drug1": "propofol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Tasimelteon.", "severity": 2}
{"drug1": "procarbazine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with dobutamine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Fluprednidene.", "severity": 2}
{"drug1": "diflunisal", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "pimozide", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with HEROIN.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with tiapride.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Tramadol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with flunisolide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with methazolamide.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Escitalopram.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclothiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with CYCLIZINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with chlormezanone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "propofol", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with oxymorphone.", "severity": 2}
{"drug1": "triazolam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with mesoridazine.", "severity": 2}
{"drug1": "propofol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with captopril.", "severity": 2}
{"drug1": "diflunisal", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "methazolamide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with dipyridamole.", "severity": 2}
{"drug1": "bifonazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with xylometazoline.", "severity": 2}
{"drug1": "loxapine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with tizanidine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with cetirizine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with protriptyline.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with desoximetasone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Pomalidomide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Lormetazepam.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with scopolamine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with acemetacin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with zaltoprofen.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with SERATRODAST.", "severity": 2}
{"drug1": "meclizine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Olopatadine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with butalbital.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with butorphanol.", "severity": 2}
{"drug1": "loxapine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Pipamperone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Eplerenone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with metoprolol.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with flumethasone.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with tolterodine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with methylprednisolone.", "severity": 2}
{"drug1": "primidone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Pizotifen.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with nitrous oxide.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Pipotiazine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with ambenonium.", "severity": 2}
{"drug1": "Normethadone", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with pargyline.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with GUANFACINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "SULFALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with SULFALENE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with clonidine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sumatriptan.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with duloxetine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with efavirenz.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with fluoxetine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Mephobarbital.", "severity": 2}
{"drug1": "mitomycin C", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mitomycin C is combined with leflunomide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Propoxycaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with oxazepam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with nalbuphine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Pramocaine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Pramocaine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with alclofenac.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with indapamide.", "severity": 2}
{"drug1": "baclofen", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with meclizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with ondansetron.", "severity": 2}
{"drug1": "Asenapine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with carprofen.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Clobetasone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with budesonide.", "severity": 2}
{"drug1": "risperidone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with enflurane.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Pipamperone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Lurasidone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with sulindac.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Clevidipine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with tiapride.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Desloratadine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with chloroquine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with nefazodone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with formestane.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Carbamylcholine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with GUANFACINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with methylphenidate.", "severity": 2}
{"drug1": "ondansetron", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with methocarbamol.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with rivastigmine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with triprolidine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with amoxapine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with suprofen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with loteprednol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with nortriptyline.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with physostigmine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with triamcinolone.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with dantrolene.", "severity": 2}
{"drug1": "procaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Pipamperone.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Varenicline.", "severity": 2}
{"drug1": "zaleplon", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with triflupromazine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with trazodone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with trimipramine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with flunarizine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with norfloxacin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with nadolol.", "severity": 2}
{"drug1": "amisulpride", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with maprotiline.", "severity": 2}
{"drug1": "miconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with felodipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with ketamine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Deferasirox.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with amoxapine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with quetiapine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with sotalol.", "severity": 2}
{"drug1": "temazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Milnacipran.", "severity": 2}
{"drug1": "tretinoin", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with brimonidine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Paliperidone.", "severity": 2}
{"drug1": "morphine", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with trichlormethiazide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with isocarboxazid.", "severity": 2}
{"drug1": "metaraminol", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with celiprolol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with felodipine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with furosemide.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with spironolactone.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "flumazenil", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumazenil is combined with clozapine.", "severity": 2}
{"drug1": "temazepam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with DESFLURANE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Pipotiazine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with oxymorphone.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with paroxetine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Clevidipine.", "severity": 2}
{"drug1": "doxepin", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with desipramine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyphylline is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with azelastine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with felbamate.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with tubocurarine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with meclizine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with trandolapril.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Levocetirizine.", "severity": 2}
{"drug1": "etodolac", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with fluocinonide.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with moclobemide.", "severity": 2}
{"drug1": "temazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with trifluoperazine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Escitalopram.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Desloratadine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Halobetasol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "Trospium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with HEROIN.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "epirizole", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with triamcinolone.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with oxymorphone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "lomustine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lomustine is combined with atorvastatin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with butamben.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with tubocurarine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Lornoxicam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Torasemide.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atazanavir is combined with Abemaciclib.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with nalbuphine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Tolcapone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Nitroprusside.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with nalidixic acid.", "severity": 2}
{"drug1": "morphine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with propofol.", "severity": 2}
{"drug1": "morphine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with acetazolamide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with primidone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with amcinonide.", "severity": 2}
{"drug1": "pergolide", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with buprenorphine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with ibuprofen.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with amcinonide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Zoledronic acid.", "severity": 2}
{"drug1": "procarbazine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with lithium ion.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with doxepin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with nimodipine.", "severity": 2}
{"drug1": "Articaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with flunarizine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bivalirudin is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Articaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with azelastine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with digitoxin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with amoxapine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with nortriptyline.", "severity": 2}
{"drug1": "antipyrine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with methylprednisolone.", "severity": 2}
{"drug1": "selegiline", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with haloperidol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Lormetazepam.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Perospirone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "selegiline", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with triflupromazine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with atorvastatin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with penbutolol.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with vigabatrin.", "severity": 2}
{"drug1": "pergolide", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with daunorubicin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with butalbital.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with timolol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with methyldopa.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with oxazepam.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "IMIQUIMOD", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with halothane.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with topiramate.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Flibanserin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with loratadine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Ketobemidone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nalbuphine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Tasimelteon.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ketoprofen.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with selegiline.", "severity": 2}
{"drug1": "clozapine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with VERAPAMIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with amoxapine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with SERTINDOLE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with paramethasone.", "severity": 2}
{"drug1": "propofol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "quazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with HEROIN.", "severity": 2}
{"drug1": "estazolam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "propranolol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "budesonide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with tubocurarine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Flibanserin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with resveratrol.", "severity": 2}
{"drug1": "propranolol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "halothane", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Lormetazepam.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with codeine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Pirlindole.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Pregabalin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with mianserin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with citalopram.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with Milnacipran.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with tolmetin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with desoximetasone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with flunarizine.", "severity": 2}
{"drug1": "reserpine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with triamterene.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Iloperidone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Flibanserin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Levobupivacaine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "etodolac", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Deferasirox.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with ramipril.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Retigabine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with amcinonide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Halazepam.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Amrinone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with carisoprodol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with proparacaine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Pizotifen.", "severity": 2}
{"drug1": "amisulpride", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with butamben.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with betaxolol.", "severity": 2}
{"drug1": "nadolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with trimipramine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with METAXALONE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Tofacitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Tofacitinib.", "severity": 2}
{"drug1": "Artemether", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with nilvadipine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "testolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with testolactone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with maprotiline.", "severity": 2}
{"drug1": "thioguanine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioguanine is combined with clozapine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Hexobarbital.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with Rotigotine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with fenoldopam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with efavirenz.", "severity": 2}
{"drug1": "propofol", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with estazolam.", "severity": 2}
{"drug1": "barnidipine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with indapamide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with metolazone.", "severity": 2}
{"drug1": "reserpine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with metolazone.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Ketobemidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with dibucaine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with fluoxetine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Articaine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with D-mannitol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with clomipramine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with quetiapine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with scopolamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with ketamine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with oxybutynin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with nitrazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Perospirone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Teriflunomide.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with codeine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Clevidipine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with nimesulide.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Ketobemidone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with chlorothiazide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Mephobarbital.", "severity": 2}
{"drug1": "nabumetone", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with mefenamic acid.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Pramocaine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with NAPROXEN.", "severity": 2}
{"drug1": "methysergide", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with tacrolimus.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Flupentixol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Phenelzine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with butalbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with triflupromazine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Flupentixol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with paroxetine.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with simvastatin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with acetazolamide.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with clenbuterol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with fludiazepam.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Bambuterol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with oxaprozin.", "severity": 2}
{"drug1": "doxycycline", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with atorvastatin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with tetracaine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Asenapine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with flunarizine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Fospropofol.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with thioridazine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with medrysone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with metolazone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with lomustine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with bromocriptine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with methyclothiazide.", "severity": 2}
{"drug1": "citalopram", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with amisulpride.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with selegiline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with flunisolide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with thalidomide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with tiapride.", "severity": 2}
{"drug1": "alprazolam", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with prochlorperazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Retigabine.", "severity": 2}
{"drug1": "practolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when practolol is combined with nicotine.", "severity": 2}
{"drug1": "propofol", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with CARTEOLOL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with mefloquine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with alclofenac.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "buspirone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with loratadine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Etoricoxib.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with flunarizine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with thioridazine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with equilin.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Fesoterodine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Retigabine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "suprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with cilazapril.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Pregabalin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Lofexidine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with bezafibrate.", "severity": 2}
{"drug1": "thiopental", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with butalbital.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with Spirapril.", "severity": 2}
{"drug1": "gabapentin", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with glutethimide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with dantrolene.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with epoprostenol.", "severity": 2}
{"drug1": "doxepin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with loteprednol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with suprofen.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with fexofenadine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with diclofenac.", "severity": 2}
{"drug1": "Spirapril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "budesonide", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with NICORANDIL.", "severity": 2}
{"drug1": "resveratrol", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with epirizole.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Pipamperone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with cilnidipine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Efonidipine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with celiprolol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with fenbufen.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "amobarbital", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with oxprenolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Olopatadine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with nadolol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with atenolol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Iloperidone.", "severity": 2}
{"drug1": "trazodone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with fludiazepam.", "severity": 2}
{"drug1": "trazodone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with chloral hydrate.", "severity": 2}
{"drug1": "reserpine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with methyldopa.", "severity": 2}
{"drug1": "clozapine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with epoprostenol.", "severity": 2}
{"drug1": "etizolam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "methoxamine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with sotalol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with brimonidine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Pramocaine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Propoxycaine.", "severity": 2}
{"drug1": "codeine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with mepivacaine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with tubocurarine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with maprotiline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with felbamate.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "tiapride", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with protriptyline.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with paramethasone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "pimozide", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with chlorzoxazone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with glutethimide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with hydrocortisone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with SERTINDOLE.", "severity": 2}
{"drug1": "cocaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Olopatadine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Pramocaine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Telmisartan.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with methyclothiazide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sildenafil is combined with Flibanserin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with primidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with chlorpheniramine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Asenapine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Empagliflozin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with metolazone.", "severity": 2}
{"drug1": "triamterene", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with papaverine.", "severity": 2}
{"drug1": "imipramine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with triamterene.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with clomipramine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with methazolamide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with budesonide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with desoximetasone.", "severity": 2}
{"drug1": "carprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with sevoflurane.", "severity": 2}
{"drug1": "halothane", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with oxprenolol.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with halcinonide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with difluprednate.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with captopril.", "severity": 2}
{"drug1": "zaleplon", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with KETAZOLAM.", "severity": 2}
{"drug1": "sotalol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Aliskiren.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with resveratrol.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Tasimelteon.", "severity": 2}
{"drug1": "zonisamide", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with vigabatrin.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Nebivolol.", "severity": 2}
{"drug1": "halothane", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with KETAZOLAM.", "severity": 2}
{"drug1": "olanzapine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with thiothixene.", "severity": 2}
{"drug1": "Perospirone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with METAXALONE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Pipotiazine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Benidipine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with DEZOCINE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Halazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with quetiapine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with methscopolamine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with hydromorphone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with cinoxacin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with thiothixene.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ranitidine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "trapidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with trapidil.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Masoprocol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with tacrolimus.", "severity": 2}
{"drug1": "brotizolam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with clidinium.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Lornoxicam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with fludiazepam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with D-mannitol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Remoxipride.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Torasemide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with amisulpride.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ruxolitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Ruxolitinib.", "severity": 2}
{"drug1": "lisinopril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with floctafenine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Thioproperazine.", "severity": 2}
{"drug1": "dapsone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with lidocaine.", "severity": 2}
{"drug1": "imipramine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with selegiline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Riociguat.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with dipyridamole.", "severity": 2}
{"drug1": "protriptyline", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with tranylcypromine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with ethotoin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with dibucaine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with atorvastatin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Aceprometazine.", "severity": 2}
{"drug1": "azelastine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "meperidine", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Mersalyl.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with haloperidol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with tolterodine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Desloratadine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Riociguat.", "severity": 2}
{"drug1": "triprolidine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with clidinium.", "severity": 2}
{"drug1": "Etomidate", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with chlormezanone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with labetalol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with imipramine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Propacetamol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with bumetanide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Paliperidone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with clomiphene.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with chlorothiazide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with quinapril.", "severity": 2}
{"drug1": "etodolac", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with salicylic acid.", "severity": 2}
{"drug1": "resveratrol", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with estrone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with isradipine.", "severity": 2}
{"drug1": "bepridil", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with apraclonidine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with amitriptyline.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Tolcapone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with tiapride.", "severity": 2}
{"drug1": "valsartan", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with sulindac.", "severity": 2}
{"drug1": "valsartan", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with chloroquine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with medrysone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Flibanserin.", "severity": 2}
{"drug1": "baclofen", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with promethazine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with metaproterenol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Iloperidone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with bepridil.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Cyamemazine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with etoposide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with mesalamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Desloratadine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with glutethimide.", "severity": 2}
{"drug1": "sulindac", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with fenbufen.", "severity": 2}
{"drug1": "ramipril", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with mecamylamine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with sulfanilamide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Deferasirox.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Pemetrexed", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Pemetrexed.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with diazepam.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with cetirizine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with edrophonium.", "severity": 2}
{"drug1": "secobarbital", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with isoflurane.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with protriptyline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clotrimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with clotrimazole.", "severity": 2}
{"drug1": "zaleplon", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with cetirizine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with tiapride.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with rescinnamine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with protriptyline.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with cilazapril.", "severity": 2}
{"drug1": "proparacaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with maprotiline.", "severity": 2}
{"drug1": "flurazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Micafungin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with butorphanol.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with equilin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with medrysone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with trimipramine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with clonidine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with losartan.", "severity": 2}
{"drug1": "proparacaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with propranolol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with estrone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with procaine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with memantine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with zaleplon.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Tasimelteon.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with gabapentin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with mecamylamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with scopolamine.", "severity": 2}
{"drug1": "methenamine", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methenamine is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "promazine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with nitrous oxide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with mepivacaine.", "severity": 2}
{"drug1": "procaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Retigabine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "morphine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Clevidipine.", "severity": 2}
{"drug1": "methadone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with triflupromazine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetaminophen is combined with prilocaine.", "severity": 2}
{"drug1": "carprofen", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with suprofen.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "prazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with maprotiline.", "severity": 2}
{"drug1": "clomipramine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with triamterene.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with SUFENTANIL.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Levetiracetam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with VERAPAMIL.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with isocarboxazid.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Retigabine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with ethotoin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with amcinonide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with captopril.", "severity": 2}
{"drug1": "Butethal", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with GUANFACINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with acebutolol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Olopatadine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Sunitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Sunitinib.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Flibanserin.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Amrinone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with cilazapril.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with carvedilol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with flunarizine.", "severity": 2}
{"drug1": "tiapride", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with clonidine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Apremilast.", "severity": 2}
{"drug1": "tetracaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with triprolidine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with topotecan.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Risedronic acid.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Bretylium.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with baclofen.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with HEROIN.", "severity": 2}
{"drug1": "nicardipine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with terazosin.", "severity": 2}
{"drug1": "losartan", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with methazolamide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Canagliflozin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with bumetanide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Lercanidipine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "foscarnet", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with foscarnet.", "severity": 2}
{"drug1": "floctafenine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with equilin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ketamine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with nisoldipine.", "severity": 2}
{"drug1": "ketamine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with doxepin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with thioridazine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "citalopram", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with meperidine.", "severity": 2}
{"drug1": "losartan", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Olsalazine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with indapamide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Pipotiazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with dibucaine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with linezolid.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with nefazodone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Amrinone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with loratadine.", "severity": 2}
{"drug1": "ramipril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with acebutolol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with ethchlorvynol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Capsaicin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Fospropofol.", "severity": 2}
{"drug1": "estazolam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with enflurane.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Rotigotine.", "severity": 2}
{"drug1": "ketamine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with methyclothiazide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with prazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with quazepam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with methyldopa.", "severity": 2}
{"drug1": "dyclonine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with METAXALONE.", "severity": 2}
{"drug1": "propofol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nitroglycerin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Etidronic acid.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with oxprenolol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Levetiracetam.", "severity": 2}
{"drug1": "meperidine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Retigabine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with KETAZOLAM.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with Escitalopram.", "severity": 2}
{"drug1": "spironolactone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with quetiapine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with felodipine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with DEZOCINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with irbesartan.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with sulfasalazine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Fluspirilene.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with flunarizine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with BISOPROLOL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with topiramate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with chlormezanone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with DEZOCINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with meperidine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with loratadine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Nepafenac.", "severity": 2}
{"drug1": "tiapride", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Pipotiazine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with dexamethasone.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Metixene.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Butylscopolamine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "estazolam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with thiopental.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "propofol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with furosemide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with AMILORIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ethosuximide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with doxazosin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Articaine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with thiopental.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with morphine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with xylometazoline.", "severity": 2}
{"drug1": "zotepine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with tiapride.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with acetazolamide.", "severity": 2}
{"drug1": "baclofen", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with flunitrazepam.", "severity": 2}
{"drug1": "bepridil", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with clonidine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "bepridil", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with propranolol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Ramelteon.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with droperidol.", "severity": 2}
{"drug1": "ketamine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pazopanib is combined with leflunomide.", "severity": 2}
{"drug1": "risperidone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with vigabatrin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with equilin.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Efonidipine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with enoxacin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with HEROIN.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with indomethacin.", "severity": 2}
{"drug1": "estazolam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Escitalopram.", "severity": 2}
{"drug1": "formestane", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with indapamide.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with isradipine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Melatonin.", "severity": 2}
{"drug1": "estazolam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with chlormezanone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Perospirone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with fludrocortisone.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Pizotifen.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Teriflunomide.", "severity": 2}
{"drug1": "cocaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with butalbital.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with equilin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with prazepam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with enflurane.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Propoxycaine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with oxprenolol.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with promethazine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Pramocaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Tapentadol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Halazepam.", "severity": 2}
{"drug1": "ipratropium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with propoxyphene.", "severity": 2}
{"drug1": "halothane", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with enalapril.", "severity": 2}
{"drug1": "proparacaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with triprolidine.", "severity": 2}
{"drug1": "halothane", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Paliperidone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with ethotoin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Fluspirilene.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Tapentadol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with DEZOCINE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with flunisolide.", "severity": 2}
{"drug1": "risperidone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with triprolidine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with brotizolam.", "severity": 2}
{"drug1": "risperidone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with methocarbamol.", "severity": 2}
{"drug1": "risperidone", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with methylphenidate.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with prilocaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with fenoldopam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with bumetanide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with papaverine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Ramelteon.", "severity": 2}
{"drug1": "clomipramine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with indapamide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with losartan.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with diazoxide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with flunarizine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Riociguat.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Metipranolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with moclobemide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "duloxetine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with MOLINDONE.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Pinaverium.", "severity": 2}
{"drug1": "etodolac", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Zoledronic acid.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with zonisamide.", "severity": 2}
{"drug1": "benazepril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with cilazapril.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with protriptyline.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with oxprenolol.", "severity": 2}
{"drug1": "etodolac", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with cetirizine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with ibuprofen.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with isoxsuprine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Asenapine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with clomipramine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Pramocaine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with isocarboxazid.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with clidinium.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with tiapride.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with spironolactone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Tolcapone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with amitriptyline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with celecoxib.", "severity": 2}
{"drug1": "apomorphine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with quetiapine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with DEZOCINE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with trifluoperazine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Lurasidone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Levetiracetam.", "severity": 2}
{"drug1": "acemetacin", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with meclizine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with isradipine.", "severity": 2}
{"drug1": "formestane", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with nalidixic acid.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with deslanoside.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Olmesartan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Tasimelteon.", "severity": 2}
{"drug1": "formestane", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with malathion.", "severity": 2}
{"drug1": "vincristine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vincristine is combined with leflunomide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Empagliflozin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Olopatadine.", "severity": 2}
{"drug1": "propantheline", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Pentolinium.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Pitavastatin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Aliskiren.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Mirabegron.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "pimozide", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with chlormezanone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Aliskiren.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "pergolide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Lurasidone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with lithium ion.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with ethotoin.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with isoxsuprine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with zotepine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with prilocaine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with prochlorperazine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Axitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Axitinib.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with isoetharine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with clonidine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with methocarbamol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with fexofenadine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with triprolidine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Escitalopram.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Pomalidomide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Levocetirizine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Levomilnacipran.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "quazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with MELPERONE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with clidinium.", "severity": 2}
{"drug1": "oxazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with halothane.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with triprolidine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with trimipramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nitroglycerin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with thiamylal.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with procaine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Varenicline.", "severity": 2}
{"drug1": "Salsalate", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with epirizole.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Levocetirizine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with isoxsuprine.", "severity": 2}
{"drug1": "thiopental", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with selegiline.", "severity": 2}
{"drug1": "dopamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with butamben.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with nadolol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with nimesulide.", "severity": 2}
{"drug1": "temazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Tolcapone.", "severity": 2}
{"drug1": "diazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with zotepine.", "severity": 2}
{"drug1": "diazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Difenoxin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Flibanserin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with amoxapine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with meclizine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Tolcapone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with nortriptyline.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "clozapine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "losartan", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Riociguat.", "severity": 2}
{"drug1": "benazepril", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with AMILORIDE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "halothane", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with isoxsuprine.", "severity": 2}
{"drug1": "clonidine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "enflurane", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "codeine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with DESFLURANE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with dyclonine.", "severity": 2}
{"drug1": "topiramate", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with clemastine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with propoxyphene.", "severity": 2}
{"drug1": "morphine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "morphine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with gabapentin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with tizanidine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Metipranolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with topiramate.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with baclofen.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ESMOLOL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with triflupromazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with cocaine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Telmisartan.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with nicardipine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with quetiapine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with methyldopa.", "severity": 2}
{"drug1": "butamben", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with CYCLIZINE.", "severity": 2}
{"drug1": "butamben", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Escitalopram.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with Apixaban.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with lisinopril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with nalbuphine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Ramelteon.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with nitroglycerin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "selegiline", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with reserpine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "midazolam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "pimozide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with efavirenz.", "severity": 2}
{"drug1": "topotecan", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topotecan is combined with leflunomide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Nebivolol.", "severity": 2}
{"drug1": "midazolam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with cilazapril.", "severity": 2}
{"drug1": "midazolam", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with triazolam.", "severity": 2}
{"drug1": "atenolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with hydralazine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with dantrolene.", "severity": 2}
{"drug1": "atenolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Varenicline.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with ethotoin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with amisulpride.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with prilocaine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with clomipramine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with tranylcypromine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with triamcinolone.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Lercanidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Sacubitril.", "severity": 2}
{"drug1": "amisulpride", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with ethosuximide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "caffeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with caffeine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "sildenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with sildenafil.", "severity": 2}
{"drug1": "doxepin", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Vilanterol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "azithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with azithromycin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with penbutolol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Fencamfamin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with amitriptyline.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with enalapril.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Tolcapone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with diclofenac.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Paliperidone.", "severity": 2}
{"drug1": "suprofen", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Teriflunomide.", "severity": 2}
{"drug1": "tiagabine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with promethazine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with clonazepam.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "mafenide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with mafenide.", "severity": 2}
{"drug1": "biperiden", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Desloratadine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Asenapine.", "severity": 2}
{"drug1": "enalapril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with hydralazine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Aceclofenac.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with lovastatin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with prednisone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with clidinium.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with procaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with lisinopril.", "severity": 2}
{"drug1": "azelastine", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with ibuprofen.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Fluspirilene.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with thiopental.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with scopolamine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "clonidine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with enalapril.", "severity": 2}
{"drug1": "meperidine", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with dextromethorphan.", "severity": 2}
{"drug1": "gabapentin", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with METAXALONE.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with buprenorphine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Retigabine.", "severity": 2}
{"drug1": "halothane", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Ramelteon.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with oxaprozin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Propiverine.", "severity": 2}
{"drug1": "sotalol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with floctafenine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with resveratrol.", "severity": 2}
{"drug1": "diflunisal", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with suprofen.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "PHENPROCOUMON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "atenolol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with indapamide.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with pentazocine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Teriflunomide.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with mecamylamine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Canagliflozin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with triamcinolone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Escitalopram.", "severity": 2}
{"drug1": "risperidone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with amobarbital.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with moclobemide.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with PAMABROM.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Teriflunomide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with CLONIXIN.", "severity": 2}
{"drug1": "lidocaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with etizolam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ethotoin", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with fexofenadine.", "severity": 2}
{"drug1": "Artemether", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with xylometazoline.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Efonidipine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with cilnidipine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Metipranolol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Nepafenac.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "thiopental", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with methocarbamol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BUPRANOLOL is combined with nicotine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BUPRANOLOL is combined with Cevimeline.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiopental", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with triprolidine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with thiothixene.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Ximelagatran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Ximelagatran.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with papaverine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with prazepam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with benazepril.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with prednisone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Nitroprusside.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with oxprenolol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with risperidone.", "severity": 2}
{"drug1": "tropicamide", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with ALFENTANIL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Pipotiazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with thiothixene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "tropicamide", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with dicyclomine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Apremilast.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Etidocaine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with oxybutynin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with etizolam.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Levocetirizine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with xylometazoline.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with butamben.", "severity": 2}
{"drug1": "hexetidine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with diltiazem.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Tasimelteon.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with dexamethasone.", "severity": 2}
{"drug1": "temazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with flunarizine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "aspirin", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Cis-mdp.", "severity": 2}
{"drug1": "methysergide", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with prednisone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with triflupromazine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with nadolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with CLONIXIN.", "severity": 2}
{"drug1": "quinapril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Droxicam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with tizanidine.", "severity": 2}
{"drug1": "citalopram", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with zotepine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Asenapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Lurasidone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with flunarizine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Fluspirilene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with estrone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with dantrolene.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Tasimelteon.", "severity": 2}
{"drug1": "practolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when practolol is combined with floctafenine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with isoflurane.", "severity": 2}
{"drug1": "Articaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with phenytoin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Capsaicin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Halobetasol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with prazepam.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Delorazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Delorazepam is combined with olanzapine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with alclofenac.", "severity": 2}
{"drug1": "sotalol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with acebutolol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with cilazapril.", "severity": 2}
{"drug1": "nimodipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Normethadone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with clonidine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with vinblastine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with butalbital.", "severity": 2}
{"drug1": "meperidine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Levocetirizine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with clonidine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Flibanserin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with azelastine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with betamethasone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "felodipine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with irbesartan.", "severity": 2}
{"drug1": "morphine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with pimozide.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rabeprazole is combined with atorvastatin.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Milnacipran.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Amrinone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Phenelzine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Metipranolol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with oxazepam.", "severity": 2}
{"drug1": "midazolam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "methysergide", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Capsaicin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Pizotifen.", "severity": 2}
{"drug1": "clidinium", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with maprotiline.", "severity": 2}
{"drug1": "zotepine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with tiagabine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with flunarizine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with dantrolene.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with vinblastine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with estazolam.", "severity": 2}
{"drug1": "zotepine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with zonisamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with citalopram.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Ketobemidone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with propoxyphene.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Teriflunomide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "efavirenz", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with tolfenamic acid.", "severity": 2}
{"drug1": "thiothixene", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with HEROIN.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "losartan", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with GUANFACINE.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with nilvadipine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Gatifloxacin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with ibuprofen.", "severity": 2}
{"drug1": "losartan", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with diflunisal.", "severity": 2}
{"drug1": "difluprednate", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with memantine.", "severity": 2}
{"drug1": "morphine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with thiopental.", "severity": 2}
{"drug1": "benztropine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with hydromorphone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Articaine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with venlafaxine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with clemastine.", "severity": 2}
{"drug1": "nadolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with amisulpride.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with diltiazem.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with fludiazepam.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with nitroglycerin.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with bumetanide.", "severity": 2}
{"drug1": "prazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with tetracaine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Flibanserin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with niflumic acid.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Iloperidone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with halothane.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with trimipramine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Pipotiazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with naratriptan.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with ambenonium.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with haloperidol.", "severity": 2}
{"drug1": "procaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "procaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Cyamemazine.", "severity": 2}
{"drug1": "tiapride", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with clidinium.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with thiamylal.", "severity": 2}
{"drug1": "procaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with meclizine.", "severity": 2}
{"drug1": "propantheline", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with methadone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Difenoxin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Ketobemidone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Pomalidomide.", "severity": 2}
{"drug1": "imipramine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with losartan.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Eplerenone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "morphine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Olopatadine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with apraclonidine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Aceprometazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with HEROIN.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Icatibant.", "severity": 2}
{"drug1": "pentostatin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentostatin is combined with leflunomide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "meprobamate", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with duloxetine.", "severity": 2}
{"drug1": "papaverine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with captopril.", "severity": 2}
{"drug1": "bepridil", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with timolol.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "HEROIN", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with baclofen.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Fosphenytoin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Normethadone", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with polythiazide.", "severity": 2}
{"drug1": "Normethadone", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with brotizolam.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with budesonide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with thiopental.", "severity": 2}
{"drug1": "Nabilone", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with penbutolol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with clonidine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Spirapril.", "severity": 2}
{"drug1": "indinavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indinavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with duloxetine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "indinavir", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indinavir is combined with toremifene.", "severity": 2}
{"drug1": "primidone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with NITROUS ACID.", "severity": 2}
{"drug1": "HEROIN", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with prazepam.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosamprenavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "HEROIN", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with methyclothiazide.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with topiramate.", "severity": 2}
{"drug1": "etizolam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Levocetirizine.", "severity": 2}
{"drug1": "morphine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with halothane.", "severity": 2}
{"drug1": "methoxamine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with isoproterenol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with reserpine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "imipramine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with isoetharine.", "severity": 2}
{"drug1": "Butethal", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with ethotoin.", "severity": 2}
{"drug1": "trazodone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with promethazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with clonazepam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Dronedarone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Dronedarone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Melatonin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with loratadine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with D-mannitol.", "severity": 2}
{"drug1": "trazodone", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Bretylium.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Canagliflozin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with thiamylal.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with rizatriptan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with naratriptan.", "severity": 2}
{"drug1": "pramipexole", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with ESMOLOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with nitrous oxide.", "severity": 2}
{"drug1": "desipramine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Tasimelteon.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Etidronic acid.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Lorcaserin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with halothane.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Flibanserin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with thiamylal.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with nimesulide.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Olopatadine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with buprenorphine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with chloroquine.", "severity": 2}
{"drug1": "equilin", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with enoxacin.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with sulindac.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Bretylium.", "severity": 2}
{"drug1": "amifostine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Conivaptan.", "severity": 2}
{"drug1": "enalapril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with carvedilol.", "severity": 2}
{"drug1": "timolol", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with trandolapril.", "severity": 2}
{"drug1": "zaleplon", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with benzyl alcohol.", "severity": 2}
{"drug1": "suprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with alclofenac.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with ethotoin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with aspirin.", "severity": 2}
{"drug1": "aspirin", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with prilocaine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "lorazepam", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with isoflurane.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nisoldipine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with METAXALONE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Ramelteon.", "severity": 2}
{"drug1": "amoxapine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with sumatriptan.", "severity": 2}
{"drug1": "propranolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with quetiapine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Milnacipran.", "severity": 2}
{"drug1": "selegiline", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with zotepine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with maprotiline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with clonidine.", "severity": 2}
{"drug1": "selegiline", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with MELPERONE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with DESFLURANE.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with thiothixene.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ketamine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Pipotiazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with pargyline.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with enoxacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with niflumic acid.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Metixene.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Midostaurin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Midostaurin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Pimecrolimus.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with hydralazine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Retigabine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with ramipril.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with MELPERONE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with zotepine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Pipamperone.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Clevidipine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with amitriptyline.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Tolcapone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with thiopental.", "severity": 2}
{"drug1": "diltiazem", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with tizanidine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with furosemide.", "severity": 2}
{"drug1": "itraconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with nimesulide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Pipamperone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with ethosuximide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Articaine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Pizotifen.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with felodipine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with alclometasone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with venlafaxine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Escitalopram.", "severity": 2}
{"drug1": "dibucaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with clemastine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Hexobarbital.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with amobarbital.", "severity": 2}
{"drug1": "floctafenine", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with celecoxib.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Mometasone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Ketobemidone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with isradipine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with clenbuterol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Eprosartan.", "severity": 2}
{"drug1": "haloperidol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with glutethimide.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with clomipramine.", "severity": 2}
{"drug1": "ramipril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with isoxsuprine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with tetracaine.", "severity": 2}
{"drug1": "promazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Fospropofol.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with Temsirolimus.", "severity": 2}
{"drug1": "metoprolol", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with atenolol.", "severity": 2}
{"drug1": "felbamate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Difenoxin.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Pomalidomide.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with hydromorphone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Tolcapone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with DESONIDE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with metoclopramide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with dantrolene.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Pomalidomide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with methocarbamol.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with spironolactone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with tubocurarine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Methadyl acetate.", "severity": 2}
{"drug1": "loxapine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with protriptyline.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Metipranolol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with DESONIDE.", "severity": 2}
{"drug1": "triprolidine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with tizanidine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with ethotoin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with thiothixene.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Cis-mdp.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Pipotiazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with dantrolene.", "severity": 2}
{"drug1": "sulindac", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with maprotiline.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with amitriptyline.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with medrysone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Tolcapone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nitroglycerin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Melatonin.", "severity": 2}
{"drug1": "temazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with meclizine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with doxepin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with zonisamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Riociguat.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with tiagabine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with duloxetine.", "severity": 2}
{"drug1": "baclofen", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with venlafaxine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with prednisone.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Ciclesonide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with rizatriptan.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "codeine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Aceprometazine.", "severity": 2}
{"drug1": "losartan", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with penbutolol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with doxepin.", "severity": 2}
{"drug1": "codeine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with MOLINDONE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "quinacrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with quinacrine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with estrone.", "severity": 2}
{"drug1": "clidinium", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with dantrolene.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Desloratadine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Imatinib is combined with oxycodone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "indapamide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with carvedilol.", "severity": 2}
{"drug1": "papaverine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Empagliflozin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with quinapril.", "severity": 2}
{"drug1": "clomipramine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with isoetharine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with bumetanide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Phenelzine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with betamethasone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with cetirizine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with tiapride.", "severity": 2}
{"drug1": "tretinoin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with protriptyline.", "severity": 2}
{"drug1": "chloroquine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with fludrocortisone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with edrophonium.", "severity": 2}
{"drug1": "propantheline", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with HEROIN.", "severity": 2}
{"drug1": "scopolamine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with pancuronium.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Butethal.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Hexobarbital.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Difenoxin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Propiverine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "procaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with sertraline.", "severity": 2}
{"drug1": "butabarbital", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with clonidine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Difenoxin.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Normethadone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with protriptyline.", "severity": 2}
{"drug1": "tizanidine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with methazolamide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Eplerenone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Ketobemidone.", "severity": 2}
{"drug1": "triazolam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with clidinium.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with propantheline.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with tizanidine.", "severity": 2}
{"drug1": "meclizine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with dantrolene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with metoprolol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with rasagiline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "clozapine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with enflurane.", "severity": 2}
{"drug1": "tolmetin", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Methadyl acetate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with amisulpride.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Pipamperone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Nebivolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Butethal", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Etidocaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with flurazepam.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with tolfenamic acid.", "severity": 2}
{"drug1": "olanzapine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with MELPERONE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with zotepine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with methyldopa.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Desloratadine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Telmisartan.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with memantine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with apraclonidine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Gatifloxacin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with mepivacaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with efavirenz.", "severity": 2}
{"drug1": "labetalol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Escitalopram.", "severity": 2}
{"drug1": "Camazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Camazepam is combined with clozapine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with clorazepate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with DESFLURANE.", "severity": 2}
{"drug1": "clonidine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "glipizide", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glipizide is combined with Carbocisteine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Retigabine.", "severity": 2}
{"drug1": "captopril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with sulfasalazine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with fenbufen.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "glutethimide", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with nefazodone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with papaverine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Metipranolol.", "severity": 2}
{"drug1": "glutethimide", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with doxepin.", "severity": 2}
{"drug1": "argatroban", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with Temsirolimus.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Aliskiren.", "severity": 2}
{"drug1": "Tramadol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with flunarizine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with duloxetine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with daunorubicin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Potassium citrate.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with benzyl alcohol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with methazolamide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Eplerenone.", "severity": 2}
{"drug1": "halothane", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with MELPERONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with trimipramine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with DESFLURANE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with cinoxacin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "citalopram", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with cabergoline.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nilvadipine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with carvedilol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Bambuterol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with prazosin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with carisoprodol.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with sulpiride.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with terbutaline.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "selegiline", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with metaproterenol.", "severity": 2}
{"drug1": "tirofiban", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with aspirin.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with tubocurarine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Lurasidone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with SERTINDOLE.", "severity": 2}
{"drug1": "loxapine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Ketobemidone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with gabapentin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with amcinonide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with oxymorphone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with levorphanol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Tolcapone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with amitriptyline.", "severity": 2}
{"drug1": "bromazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with trimipramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with clidinium.", "severity": 2}
{"drug1": "bromazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with procaine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Arformoterol.", "severity": 2}
{"drug1": "propofol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Butethal.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Normethadone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "propofol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Hexobarbital.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "propofol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with penbutolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with clidinium.", "severity": 2}
{"drug1": "quinapril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with nadolol.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with baclofen.", "severity": 2}
{"drug1": "halothane", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with efavirenz.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with felodipine.", "severity": 2}
{"drug1": "dapsone", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with phenytoin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with alclometasone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with amoxapine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with nortriptyline.", "severity": 2}
{"drug1": "labetalol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Tasimelteon.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Normethadone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with trazodone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Ketobemidone.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with vigabatrin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with hydromorphone.", "severity": 2}
{"drug1": "loxapine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Retigabine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "flurazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with levodopa.", "severity": 2}
{"drug1": "Melatonin", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with tiagabine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Pipotiazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Pazopanib.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "epinastine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with aspirin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with brotizolam.", "severity": 2}
{"drug1": "ROLITETRACYCLINE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ROLITETRACYCLINE is combined with atorvastatin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with doxepin.", "severity": 2}
{"drug1": "isradipine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with terazosin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with imipramine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Naftifine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with topiramate.", "severity": 2}
{"drug1": "Torasemide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with mecamylamine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with cinoxacin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Etidocaine.", "severity": 2}
{"drug1": "promazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with vigabatrin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with GUANFACINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with triazolam.", "severity": 2}
{"drug1": "timolol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with mecamylamine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with amobarbital.", "severity": 2}
{"drug1": "methadone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Pramocaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "quazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Retigabine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Lumiracoxib.", "severity": 2}
{"drug1": "pentazocine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with benzocaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with phentolamine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Bortezomib.", "severity": 2}
{"drug1": "ritodrine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with Ephedrine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with ESMOLOL.", "severity": 2}
{"drug1": "ritodrine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with PROCATEROL.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with budesonide.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "trimipramine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with isoetharine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Iloperidone.", "severity": 2}
{"drug1": "propranolol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with KETAZOLAM.", "severity": 2}
{"drug1": "benazepril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with carvedilol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with memantine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with furosemide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with ondansetron.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Articaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with tiagabine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with cocaine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with hydromorphone.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with methocarbamol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with mesoridazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with maprotiline.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with triprolidine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with dibucaine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with metoclopramide.", "severity": 2}
{"drug1": "reserpine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Iloperidone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Propoxycaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with brimonidine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with norfloxacin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with celecoxib.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with carvedilol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nitrendipine.", "severity": 2}
{"drug1": "butamben", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Tasimelteon.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with clonazepam.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with promethazine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with resveratrol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "topiramate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Ramelteon.", "severity": 2}
{"drug1": "Tramadol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with fosinopril.", "severity": 2}
{"drug1": "trazodone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with tranylcypromine.", "severity": 2}
{"drug1": "topiramate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with lithium ion.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Mirabegron.", "severity": 2}
{"drug1": "rasagiline", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with tiapride.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with zonisamide.", "severity": 2}
{"drug1": "baclofen", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with vigabatrin.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Tapentadol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with proparacaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Lumiracoxib.", "severity": 2}
{"drug1": "baclofen", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with chlorzoxazone.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with Pitavastatin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with sotalol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Desloratadine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with flunarizine.", "severity": 2}
{"drug1": "Butethal", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with BISOPROLOL.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Escitalopram.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Nabilone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with moclobemide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Temsirolimus.", "severity": 2}
{"drug1": "nicergoline", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with norfloxacin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with chloral hydrate.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with nitrendipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Etidocaine.", "severity": 2}
{"drug1": "linezolid", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with promazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "reserpine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with amoxapine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with meclizine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with thioridazine.", "severity": 2}
{"drug1": "enalapril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with tenoxicam.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ketorolac.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with acebutolol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with nabumetone.", "severity": 2}
{"drug1": "enalapril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with nabumetone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "enalapril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ketorolac.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with venlafaxine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with sumatriptan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with chlorzoxazone.", "severity": 2}
{"drug1": "temazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with Ephedrine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sildenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sildenafil.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with ouabain.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with clomipramine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with phenytoin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Fospropofol.", "severity": 2}
{"drug1": "methazolamide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with papaverine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Normethadone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with loteprednol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with duloxetine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Crizotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Crizotinib.", "severity": 2}
{"drug1": "meprobamate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with levodopa.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with fluoxetine.", "severity": 2}
{"drug1": "loxapine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with thioridazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with chlorprothixene.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with atorvastatin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with dantrolene.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with simvastatin.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with clomipramine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Normethadone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Perospirone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with imipramine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Aripiprazole.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with sevoflurane.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with felbamate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with resveratrol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Olopatadine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Eprosartan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methadone", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with meprobamate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Riociguat.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Fencamfamin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with diflorasone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with tetracaine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Ethylmorphine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Fluprednidene.", "severity": 2}
{"drug1": "nabumetone", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Efonidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Lacidipine.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Benidipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with cilazapril.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Riociguat.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with cilnidipine.", "severity": 2}
{"drug1": "sulfacetamide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfacetamide is combined with mecamylamine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with oxprenolol.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with manidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with triazolam.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with mefloquine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with dexamethasone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with ethosuximide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Etomidate.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with AMILORIDE.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERYTHRITYL TETRANITRATE is combined with rosiglitazone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with doxazosin.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Tapentadol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Etidocaine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with labetalol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with quetiapine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with flurbiprofen.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with tetracaine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with methoxyflurane.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Vinflunine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Vinflunine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with flurandrenolide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with methazolamide.", "severity": 2}
{"drug1": "methadone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with thiopental.", "severity": 2}
{"drug1": "docetaxel", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with bicalutamide.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with duloxetine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with fluoxetine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "butabarbital", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with tiapride.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Cyamemazine.", "severity": 2}
{"drug1": "halothane", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with nortriptyline.", "severity": 2}
{"drug1": "Apremilast", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with paramethasone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with amoxapine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with cinoxacin.", "severity": 2}
{"drug1": "diazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with clonidine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with clomipramine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "reserpine", "drug2": "butabarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with butabarbital.", "severity": 2}
{"drug1": "reserpine", "drug2": "temazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with temazepam.", "severity": 2}
{"drug1": "reserpine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with methyclothiazide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with efavirenz.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Halobetasol.", "severity": 2}
{"drug1": "resveratrol", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Salsalate.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "topiramate", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Milnacipran.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with salicylamide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with fenbufen.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with flunarizine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with fluoxetine.", "severity": 2}
{"drug1": "promazine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with pentazocine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with tiapride.", "severity": 2}
{"drug1": "thiopental", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Escitalopram.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with doxazosin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with dantrolene.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ethosuximide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with AMILORIDE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "4-Methoxyphenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with 4-Methoxyphenol.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with nefazodone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with labetalol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with chlorzoxazone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "trazodone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with ethosuximide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with metoclopramide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with clozapine.", "severity": 2}
{"drug1": "clonidine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with GUANFACINE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Nebivolol.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with mefloquine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with butalbital.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "enflurane", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with zaltoprofen.", "severity": 2}
{"drug1": "Torasemide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Nitroprusside.", "severity": 2}
{"drug1": "cerulenin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with nilvadipine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with amitriptyline.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Propiverine.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with citalopram.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Clevidipine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with GUANFACINE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with homoharringtonine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Calcipotriol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with pilocarpine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with chloral hydrate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Ketobemidone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with DESFLURANE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with glutethimide.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with oxycodone.", "severity": 2}
{"drug1": "suprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with diflorasone.", "severity": 2}
{"drug1": "losartan", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with mesalamine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with gabapentin.", "severity": 2}
{"drug1": "clonidine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with felbamate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with felbamate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with duloxetine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Etoricoxib.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clenbuterol is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with eperisone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with zopiclone.", "severity": 2}
{"drug1": "losartan", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with captopril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Flibanserin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "losartan", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with acebutolol.", "severity": 2}
{"drug1": "enflurane", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with GUANFACINE.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with desipramine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with diflorasone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with pyridostigmine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "methadone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Perospirone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Mometasone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with trandolapril.", "severity": 2}
{"drug1": "lorazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "Articaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with methocarbamol.", "severity": 2}
{"drug1": "Articaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with triprolidine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with triamterene.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Lurasidone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with desoximetasone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with penbutolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with methazolamide.", "severity": 2}
{"drug1": "buspirone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with procaine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Efonidipine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Iloperidone.", "severity": 2}
{"drug1": "loxapine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Etidocaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "retinol", "drug2": "Bexarotene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when retinol is combined with Bexarotene.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with nortriptyline.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Fluprednidene.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with zonisamide.", "severity": 2}
{"drug1": "ethotoin", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with chlorpheniramine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with sulpiride.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Pipotiazine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with flunisolide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with apraclonidine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with acemetacin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with felodipine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "amifostine", "drug2": "amphotericin b", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with amphotericin b.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with desoximetasone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with butamben.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with dexamethasone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with butorphanol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with tetracaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Methadyl acetate.", "severity": 2}
{"drug1": "methysergide", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with doxorubicin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with glutethimide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with apraclonidine.", "severity": 2}
{"drug1": "quazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with thiothixene.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Etidronic acid.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with prazepam.", "severity": 2}
{"drug1": "HEROIN", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with bumetanide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with chlorothiazide.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoxsuprine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with risperidone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Aliskiren.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with nimesulide.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with meperidine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with histamine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Pinaverium.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Icatibant.", "severity": 2}
{"drug1": "codeine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with propofol.", "severity": 2}
{"drug1": "codeine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with acetazolamide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with alclofenac.", "severity": 2}
{"drug1": "lorazepam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with zaleplon.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with butamben.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with mefloquine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with bepridil.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Lurasidone.", "severity": 2}
{"drug1": "methysergide", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with cocaine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Potassium citrate.", "severity": 2}
{"drug1": "metolazone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with chlorothiazide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Levobupivacaine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with diltiazem.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with cetirizine.", "severity": 2}
{"drug1": "metolazone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with bumetanide.", "severity": 2}
{"drug1": "trazodone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with topiramate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with phenobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with CYCLIZINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Oxetacaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with chlormezanone.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with citalopram.", "severity": 2}
{"drug1": "flurazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Tolcapone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with CYCLIZINE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "morniflumate", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with difluprednate.", "severity": 2}
{"drug1": "acemetacin", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with halcinonide.", "severity": 2}
{"drug1": "morniflumate", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with fenbufen.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Pirlindole.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Toloxatone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with promethazine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with clonazepam.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Melatonin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with tizanidine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with desipramine.", "severity": 2}
{"drug1": "loratadine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with dexamethasone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Estrone sulfate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with proparacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with butalbital.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "roxithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with roxithromycin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ondansetron", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with etoposide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "propofol", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nifedipine.", "severity": 2}
{"drug1": "propofol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "zotepine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Pramocaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "diazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with clonidine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with maprotiline.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with acebutolol.", "severity": 2}
{"drug1": "Cladribine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cladribine is combined with leflunomide.", "severity": 2}
{"drug1": "pancuronium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with nalbuphine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with galanthamine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "benazepril", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with propranolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Telmisartan.", "severity": 2}
{"drug1": "Mometasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with malathion.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Deferasirox.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with dexamethasone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with antipyrine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Pizotifen.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with promethazine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with clonazepam.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with salicylic acid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Aceclofenac.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with glutethimide.", "severity": 2}
{"drug1": "benazepril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Teriflunomide.", "severity": 2}
{"drug1": "Nabilone", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with BISOPROLOL.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nelfinavir is combined with oxycodone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with sevoflurane.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with irbesartan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with clonidine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with nisoldipine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with perphenazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with bifonazole.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with olanzapine.", "severity": 2}
{"drug1": "promethazine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with desipramine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Mephobarbital.", "severity": 2}
{"drug1": "fenbufen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Pipotiazine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with zonisamide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Metixene.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Butethal", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with nortriptyline.", "severity": 2}
{"drug1": "ipratropium", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with oxyphenonium.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with tiagabine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with celecoxib.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with gabapentin.", "severity": 2}
{"drug1": "azelastine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with hydrocortisone.", "severity": 2}
{"drug1": "timolol", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with fosinopril.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with penbutolol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with fludrocortisone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with quinapril.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with chlorothiazide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Phenelzine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with mepivacaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with bumetanide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with haloperidol.", "severity": 2}
{"drug1": "ramipril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with suprofen.", "severity": 2}
{"drug1": "clonidine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with clidinium.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nisoldipine.", "severity": 2}
{"drug1": "losartan", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with doxepin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with mepivacaine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with nefazodone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Etomidate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Desloratadine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with methylphenidate.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with methocarbamol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with triprolidine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with barnidipine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with SERATRODAST.", "severity": 2}
{"drug1": "brotizolam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with dantrolene.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with mefloquine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with glutethimide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Flibanserin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with quetiapine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Agomelatine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with tranylcypromine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Tasimelteon.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Estrone sulfate.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with brotizolam.", "severity": 2}
{"drug1": "Droxicam", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with tetracaine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with flunisolide.", "severity": 2}
{"drug1": "Droxicam", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with amcinonide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Metipranolol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Topiroxostat.", "severity": 2}
{"drug1": "meperidine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "zotepine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with GUANFACINE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with isoxsuprine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with paramethasone.", "severity": 2}
{"drug1": "etodolac", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Metixene", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Tramadol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Articaine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with olanzapine.", "severity": 2}
{"drug1": "meperidine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with bromazepam.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with nimodipine.", "severity": 2}
{"drug1": "baclofen", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with clomipramine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Asenapine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with propantheline.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with isoxsuprine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with methocarbamol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with spironolactone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with triprolidine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "procyclidine", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with oxyphenonium.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "valsartan", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with metoprolol.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with nalbuphine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Nebivolol.", "severity": 2}
{"drug1": "enflurane", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Halazepam.", "severity": 2}
{"drug1": "enflurane", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with proparacaine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with alclometasone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with oxazepam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with etizolam.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with SUFENTANIL.", "severity": 2}
{"drug1": "levorphanol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Desloratadine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Valrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Valrubicin.", "severity": 2}
{"drug1": "propofol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Etidocaine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with desipramine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with fenbufen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "risperidone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with lidocaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with lidocaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "amsacrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with amsacrine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Levocetirizine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Fospropofol.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with nisoldipine.", "severity": 2}
{"drug1": "pergolide", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with topotecan.", "severity": 2}
{"drug1": "sertraline", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Lorcaserin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Etomidate.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Ropivacaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with bupivacaine.", "severity": 2}
{"drug1": "estazolam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with baclofen.", "severity": 2}
{"drug1": "fosinopril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with SERATRODAST.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "butabarbital", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with flunitrazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "morniflumate", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with ibuprofen.", "severity": 2}
{"drug1": "thiamylal", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with HEROIN.", "severity": 2}
{"drug1": "dyclonine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with nortriptyline.", "severity": 2}
{"drug1": "dyclonine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with amoxapine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with mefenamic acid.", "severity": 2}
{"drug1": "bromazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with desipramine.", "severity": 2}
{"drug1": "temazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Mirabegron.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Pinaverium.", "severity": 2}
{"drug1": "midazolam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Agomelatine.", "severity": 2}
{"drug1": "temazepam", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with haloperidol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with epirizole.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with nitrazepam.", "severity": 2}
{"drug1": "trimipramine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with zonisamide.", "severity": 2}
{"drug1": "Micafungin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with nimesulide.", "severity": 2}
{"drug1": "clozapine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with triamterene.", "severity": 2}
{"drug1": "meprobamate", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with MELPERONE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with formestane.", "severity": 2}
{"drug1": "lidocaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "sotalol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with clonidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with HEROIN.", "severity": 2}
{"drug1": "Halazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with ethotoin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with propranolol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "felbamate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with vigabatrin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Desloratadine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Telmisartan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Desloratadine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with apraclonidine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with mepivacaine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Mometasone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Flibanserin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with methyldopa.", "severity": 2}
{"drug1": "vinblastine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinblastine is combined with clozapine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Benidipine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Azelnidipine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with cilnidipine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Efonidipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Flibanserin.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Lacidipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with topiramate.", "severity": 2}
{"drug1": "fosinopril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with tolmetin.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with nimesulide.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Flibanserin.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with diflunisal.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with cinoxacin.", "severity": 2}
{"drug1": "practolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when practolol is combined with pilocarpine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with tiagabine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ethotoin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with prilocaine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with antipyrine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Icatibant.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with ALFENTANIL.", "severity": 2}
{"drug1": "lithium ion", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with butamben.", "severity": 2}
{"drug1": "procaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with fexofenadine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Propoxycaine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Pramocaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Articaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with chlorprothixene.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with resveratrol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with glutethimide.", "severity": 2}
{"drug1": "selegiline", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with metoclopramide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Salsalate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Salmeterol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with promazine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with spironolactone.", "severity": 2}
{"drug1": "midazolam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with olanzapine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with physostigmine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with diazepam.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with Gatifloxacin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Fospropofol.", "severity": 2}
{"drug1": "felbamate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Pipotiazine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with clonazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with mecamylamine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with metoclopramide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Etidronic acid.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "triazolam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with dibucaine.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with nifedipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "timolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with acetylcholine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Aliskiren.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with fleroxacin.", "severity": 2}
{"drug1": "propofol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Olopatadine.", "severity": 2}
{"drug1": "ramipril", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nisoldipine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with alclometasone.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with nilvadipine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with epirizole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with meclizine.", "severity": 2}
{"drug1": "buspirone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with nortriptyline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with cetirizine.", "severity": 2}
{"drug1": "donepezil", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when donepezil is combined with nicotine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with protriptyline.", "severity": 2}
{"drug1": "enflurane", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with benzyl alcohol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with diazepam.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Pregabalin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Ciclesonide.", "severity": 2}
{"drug1": "butamben", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Pomalidomide.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with nilvadipine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "progesterone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when progesterone is combined with atorvastatin.", "severity": 2}
{"drug1": "butamben", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "fenbufen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with betamethasone.", "severity": 2}
{"drug1": "tioconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with nicardipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Ropivacaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with bupivacaine.", "severity": 2}
{"drug1": "memantine", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when memantine is combined with acetylcholine.", "severity": 2}
{"drug1": "buspirone", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with thiopental.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with quazepam.", "severity": 2}
{"drug1": "clomipramine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with KETAZOLAM.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with ethosuximide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "buspirone", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with triazolam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with oxprenolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Flupentixol.", "severity": 2}
{"drug1": "Trospium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with gabapentin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "quinapril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with halothane.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with doxazosin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with methoxyflurane.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with edrophonium.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with maprotiline.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with desipramine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with mesoridazine.", "severity": 2}
{"drug1": "timolol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with lisinopril.", "severity": 2}
{"drug1": "propofol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Empagliflozin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with enflurane.", "severity": 2}
{"drug1": "nabumetone", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with tolfenamic acid.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Flibanserin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with chlorthalidone.", "severity": 2}
{"drug1": "diazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with clidinium.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Fencamfamin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with flumethasone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Desloratadine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with quetiapine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with dipivefrin.", "severity": 2}
{"drug1": "prazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with mepivacaine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with epoprostenol.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with clomipramine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with isocarboxazid.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with bupivacaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Ropivacaine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Etomidate.", "severity": 2}
{"drug1": "alprostadil", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprostadil is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with mecamylamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Flupentixol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with baclofen.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Articaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with ethchlorvynol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with estrone.", "severity": 2}
{"drug1": "felodipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with hydralazine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with tranylcypromine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with DESONIDE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Thioproperazine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with thiothixene.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with hydromorphone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with nitrazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Tolcapone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with amitriptyline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with mycophenolic acid.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Flibanserin.", "severity": 2}
{"drug1": "biperiden", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with quetiapine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with triamterene.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Retigabine.", "severity": 2}
{"drug1": "thiopental", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with paroxetine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Empagliflozin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with topiramate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Aceprometazine.", "severity": 2}
{"drug1": "benazepril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with meperidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with MOLINDONE.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Pinaverium.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Levocetirizine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with amcinonide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with hydrocortisone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with chlormezanone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with etodolac.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with triamterene.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with SERTINDOLE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with tizanidine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with mefloquine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with nadolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Apremilast.", "severity": 2}
{"drug1": "rasagiline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with formoterol.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Iloperidone.", "severity": 2}
{"drug1": "prazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with lovastatin.", "severity": 2}
{"drug1": "morphine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with bromazepam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with minoxidil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with leflunomide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Epirubicin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nicardipine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Propoxycaine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Perospirone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Pramocaine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with penbutolol.", "severity": 2}
{"drug1": "paroxetine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with protriptyline.", "severity": 2}
{"drug1": "midodrine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with dobutamine.", "severity": 2}
{"drug1": "citalopram", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with MELPERONE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with vinorelbine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with clozapine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Ropivacaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with bupivacaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Etomidate.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with metolazone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with METAXALONE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with CARTEOLOL.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "levodopa", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with tranylcypromine.", "severity": 2}
{"drug1": "atenolol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with sulpiride.", "severity": 2}
{"drug1": "polythiazide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with digoxin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with zonisamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with tiagabine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with trimipramine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with ondansetron.", "severity": 2}
{"drug1": "benazepril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ketoprofen.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with tizanidine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "amsacrine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amsacrine is combined with clozapine.", "severity": 2}
{"drug1": "diazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "metaraminol", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with isoproterenol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with doxepin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "midodrine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with isoproterenol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with scopolamine.", "severity": 2}
{"drug1": "timolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with quetiapine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with risperidone.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with nefazodone.", "severity": 2}
{"drug1": "suprofen", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with salicylamide.", "severity": 2}
{"drug1": "morphine", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with PAMABROM.", "severity": 2}
{"drug1": "rasagiline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with periciazine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with loteprednol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Sacubitril.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Pipotiazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with thiothixene.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "methoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with methoxamine.", "severity": 2}
{"drug1": "morphine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with midazolam.", "severity": 2}
{"drug1": "benztropine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with propoxyphene.", "severity": 2}
{"drug1": "lorazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with topiramate.", "severity": 2}
{"drug1": "butamben", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with vigabatrin.", "severity": 2}
{"drug1": "Articaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "probenecid", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when probenecid is combined with mecamylamine.", "severity": 2}
{"drug1": "epirizole", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "cabergoline", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with paroxetine.", "severity": 2}
{"drug1": "enalapril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with NAPROXEN.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with streptozocin.", "severity": 2}
{"drug1": "enalapril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with mefenamic acid.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with doxepin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with procarbazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with hydralazine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with indapamide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nisoldipine.", "severity": 2}
{"drug1": "furosemide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with dipyridamole.", "severity": 2}
{"drug1": "scopolamine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Alvimopan", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alvimopan is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Halazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with vinblastine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with propofol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with proparacaine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with trimipramine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with cyclophosphamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with epirizole.", "severity": 2}
{"drug1": "flumethasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with ethosuximide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with equilin.", "severity": 2}
{"drug1": "carprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with medrysone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with trimipramine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Agomelatine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Bretylium.", "severity": 2}
{"drug1": "thiothixene", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with nitrous oxide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with captopril.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with Milnacipran.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Aliskiren.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "methadone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Olopatadine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with chlormezanone.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Retigabine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Flibanserin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with desoximetasone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Flupentixol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with scopolamine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "furosemide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with sulpiride.", "severity": 2}
{"drug1": "furosemide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with digoxin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with dantrolene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with chloral hydrate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "altretamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with altretamine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Pefloxacin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with tizanidine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Bretylium.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Articaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Lenalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Lenalidomide.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with isoxsuprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with isocarboxazid.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Pomalidomide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Risedronic acid.", "severity": 2}
{"drug1": "promazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with vigabatrin.", "severity": 2}
{"drug1": "promazine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "promazine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with benzocaine.", "severity": 2}
{"drug1": "sulindac", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with gabapentin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with medrysone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with tranylcypromine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Clobetasone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Milnacipran.", "severity": 2}
{"drug1": "tiapride", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Tasimelteon.", "severity": 2}
{"drug1": "Naftifine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with triamcinolone.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with fluoxetine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with nicardipine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "clozapine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with apraclonidine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Melatonin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with GUANFACINE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with baclofen.", "severity": 2}
{"drug1": "selegiline", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Isometheptene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Ropivacaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with bupivacaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Olopatadine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Etomidate.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Teriflunomide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with cisapride.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Lorcaserin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Tolcapone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Melatonin.", "severity": 2}
{"drug1": "methoxamine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with celiprolol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Droxicam.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with dantrolene.", "severity": 2}
{"drug1": "Naftifine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with gabapentin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with clemastine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with flurazepam.", "severity": 2}
{"drug1": "Naftifine", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with oxaprozin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with felbamate.", "severity": 2}
{"drug1": "resveratrol", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with paramethasone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with prochlorperazine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with mecamylamine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Fluprednidene.", "severity": 2}
{"drug1": "flunisolide", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with ROSOXACIN.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with fludiazepam.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with indapamide.", "severity": 2}
{"drug1": "pimozide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with propoxyphene.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with fenoldopam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Tolcapone.", "severity": 2}
{"drug1": "cerulenin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with bepridil.", "severity": 2}
{"drug1": "tolmetin", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with diflunisal.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with amitriptyline.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nadolol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with efavirenz.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Paliperidone.", "severity": 2}
{"drug1": "quazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with ondansetron.", "severity": 2}
{"drug1": "clidinium", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with venlafaxine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Retigabine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "THYMOL", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with nifedipine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with CLONIXIN.", "severity": 2}
{"drug1": "methysergide", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ranitidine.", "severity": 2}
{"drug1": "aspirin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with MELPERONE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with zotepine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with isoproterenol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with minoxidil.", "severity": 2}
{"drug1": "levorphanol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with imipramine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Fluspirilene.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Halazepam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with methocarbamol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with triprolidine.", "severity": 2}
{"drug1": "butalbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with cetirizine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with diazoxide.", "severity": 2}
{"drug1": "clemastine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with fexofenadine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with salicylamide.", "severity": 2}
{"drug1": "sulindac", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with ZILEUTON.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with DEZOCINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with papaverine.", "severity": 2}
{"drug1": "methadone", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with levorphanol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with oxazepam.", "severity": 2}
{"drug1": "resveratrol", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Asenapine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with fexofenadine.", "severity": 2}
{"drug1": "clonidine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with quetiapine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with nalbuphine.", "severity": 2}
{"drug1": "ketamine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with sevoflurane.", "severity": 2}
{"drug1": "ketamine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with chlorprothixene.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with rabeprazole.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with desipramine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Risedronic acid.", "severity": 2}
{"drug1": "proparacaine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with cocaine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with nimesulide.", "severity": 2}
{"drug1": "midazolam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with diflorasone.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with diflorasone.", "severity": 2}
{"drug1": "nystatin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with eperisone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Teriflunomide.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Remoxipride.", "severity": 2}
{"drug1": "naratriptan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with loxapine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Pipotiazine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Propiverine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with fosinopril.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with irbesartan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "estramustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with estramustine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Empagliflozin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "actinomycin D", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with actinomycin D.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Levetiracetam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with zaltoprofen.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Lornoxicam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "lomefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with lomefloxacin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with zopiclone.", "severity": 2}
{"drug1": "sotalol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "tetracaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with venlafaxine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with oxymorphone.", "severity": 2}
{"drug1": "tetracaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with clemastine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Tasimelteon.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with fexofenadine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Rosuvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with cilnidipine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with vigabatrin.", "severity": 2}
{"drug1": "clidinium", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Pipotiazine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naloxone is combined with Naloxegol.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with felodipine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Efonidipine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with cilazapril.", "severity": 2}
{"drug1": "Butethal", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Tolcapone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with manidipine.", "severity": 2}
{"drug1": "Butethal", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with amitriptyline.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with ESMOLOL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "temazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with edrophonium.", "severity": 2}
{"drug1": "zaleplon", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with tetracaine.", "severity": 2}
{"drug1": "ketamine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with chlormezanone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with phenytoin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Normethadone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with clidinium.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with meperidine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with thiothixene.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Thioproperazine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Pipotiazine.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with mecamylamine.", "severity": 2}
{"drug1": "minocycline", "drug2": "Bexarotene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minocycline is combined with Bexarotene.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with imipramine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Aliskiren.", "severity": 2}
{"drug1": "Salsalate", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with formestane.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with clidinium.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "proparacaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with topiramate.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "triamterene", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with prazosin.", "severity": 2}
{"drug1": "ramipril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with papaverine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with trimipramine.", "severity": 2}
{"drug1": "ramipril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nifedipine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Lurasidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with zopiclone.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Tixocortol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with carprofen.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with nitroglycerin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with OLODATEROL.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Vilanterol.", "severity": 2}
{"drug1": "pramipexole", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with cilazapril.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with flunitrazepam.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Tapentadol.", "severity": 2}
{"drug1": "codeine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with gabapentin.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Telmisartan.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Etomidate.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Cis-mdp.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with bicalutamide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with mecamylamine.", "severity": 2}
{"drug1": "diazepam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with ketamine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with methyldopa.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with triamcinolone.", "severity": 2}
{"drug1": "bepridil", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with simvastatin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Oxetacaine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with celecoxib.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Milnacipran.", "severity": 2}
{"drug1": "fenbufen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "propylthiouracil", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propylthiouracil is combined with clozapine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with flumethasone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Efonidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with loratadine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with efavirenz.", "severity": 2}
{"drug1": "lidocaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with mesoridazine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with chlorothiazide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with amisulpride.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with bumetanide.", "severity": 2}
{"drug1": "benztropine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with scopolamine.", "severity": 2}
{"drug1": "procaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Flibanserin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "ethanol", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with selegiline.", "severity": 2}
{"drug1": "Etomidate", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with MOLINDONE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with apraclonidine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with acemetacin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with desipramine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Aceprometazine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with indomethacin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Difenoxin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with levodopa.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Drospirenone.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with olanzapine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with sulpiride.", "severity": 2}
{"drug1": "sertraline", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Aceprometazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with cetirizine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with fluvastatin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with prilocaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with ethotoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with DEZOCINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "sertraline", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with MOLINDONE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with triprolidine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with spironolactone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with halothane.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with methocarbamol.", "severity": 2}
{"drug1": "paroxetine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with isocarboxazid.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with meclizine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with METAXALONE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with clomipramine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "diazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Ciclesonide.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with protriptyline.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Milnacipran.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with cetirizine.", "severity": 2}
{"drug1": "meperidine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with dibucaine.", "severity": 2}
{"drug1": "halothane", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Olmesartan.", "severity": 2}
{"drug1": "apomorphine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with bromocriptine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with ropinirole.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with suprofen.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with loteprednol.", "severity": 2}
{"drug1": "halothane", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with topiramate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "tiapride", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Iloperidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Fospropofol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with PAMABROM.", "severity": 2}
{"drug1": "Butethal", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with METAXALONE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with niflumic acid.", "severity": 2}
{"drug1": "meprobamate", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with tetracaine.", "severity": 2}
{"drug1": "formestane", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Pefloxacin.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "formestane", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with sertraline.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with fludiazepam.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with CLONIXIN.", "severity": 2}
{"drug1": "valsartan", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Olopatadine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with trandolapril.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Loxoprofen.", "severity": 2}
{"drug1": "ketorolac", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with prednisone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with zopiclone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Telmisartan.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with apraclonidine.", "severity": 2}
{"drug1": "ramipril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Aliskiren.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with alclofenac.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with methyldopa.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with isoxsuprine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "epirizole", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Clobetasone.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Vecuronium.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with flurbiprofen.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Naftifine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with dipivefrin.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with pancuronium.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with etizolam.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with butalbital.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with dichlorphenamide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with oxycodone.", "severity": 2}
{"drug1": "brotizolam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with fexofenadine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with felodipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Nabilone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with brimonidine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with ropinirole.", "severity": 2}
{"drug1": "pergolide", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Regorafenib.", "severity": 2}
{"drug1": "zaleplon", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with methocarbamol.", "severity": 2}
{"drug1": "zaleplon", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with triprolidine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Propiverine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with ZILEUTON.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Levetiracetam.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with dibucaine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with flunisolide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with alclofenac.", "severity": 2}
{"drug1": "medrysone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Echothiophate.", "severity": 2}
{"drug1": "loxapine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with DESFLURANE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with zonisamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with atenolol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Normethadone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with amoxapine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with tiagabine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with nortriptyline.", "severity": 2}
{"drug1": "lidocaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with meclizine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Metipranolol.", "severity": 2}
{"drug1": "temazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with amisulpride.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EDOXABAN is combined with Nintedanib.", "severity": 2}
{"drug1": "clozapine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with butamben.", "severity": 2}
{"drug1": "chloroxine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with flunarizine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Empagliflozin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "ketorolac", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with celecoxib.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with Paricalcitol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with equilin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with lidocaine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Pentolinium.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Pramocaine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Fencamfamin.", "severity": 2}
{"drug1": "Butethal", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Propoxycaine.", "severity": 2}
{"drug1": "epirizole", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with desoximetasone.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Ziprasidone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with chlorthalidone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with nimesulide.", "severity": 2}
{"drug1": "ibudilast", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with methazolamide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with methylprednisolone.", "severity": 2}
{"drug1": "ketamine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with topiramate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with ethosuximide.", "severity": 2}
{"drug1": "codeine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "doxepin", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with rasagiline.", "severity": 2}
{"drug1": "doxepin", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with PROCATEROL.", "severity": 2}
{"drug1": "codeine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with pimozide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with nicardipine.", "severity": 2}
{"drug1": "codeine", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with cyclothiazide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with tizanidine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with HEROIN.", "severity": 2}
{"drug1": "oxycodone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with brotizolam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Nitroprusside.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Spirapril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Demecarium.", "severity": 2}
{"drug1": "methadone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with methazolamide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Tolcapone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with cilazapril.", "severity": 2}
{"drug1": "epirizole", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Eprosartan.", "severity": 2}
{"drug1": "selegiline", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with promazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with spironolactone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Difenoxin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with dibucaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with apraclonidine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with METAXALONE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with GUANFACINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with triprolidine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with valsartan.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with ramipril.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Difenoxin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "triazolam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with nitrazepam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "gemcitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with gemcitabine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Epirubicin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with teniposide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with leflunomide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with DEZOCINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with maprotiline.", "severity": 2}
{"drug1": "THYMOL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with VERAPAMIL.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "methazolamide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with D-mannitol.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with ethosuximide.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with tiapride.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with fluvoxamine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with HYDROCODONE.", "severity": 2}
{"drug1": "captopril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with fexofenadine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with tretinoin.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with physostigmine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with fluocinonide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with rivastigmine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Levocetirizine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "isradipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with thiopental.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Asenapine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with felodipine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with DESONIDE.", "severity": 2}
{"drug1": "alprostadil", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprostadil is combined with mesalamine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with mecamylamine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with toremifene.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with estrone.", "severity": 2}
{"drug1": "propranolol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with furosemide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ipratropium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with codeine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "alclofenac", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with methylprednisolone.", "severity": 2}
{"drug1": "methadone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with atorvastatin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Ramelteon.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Tolcapone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "trazodone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Pizotifen.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Clevidipine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Pipamperone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with indomethacin.", "severity": 2}
{"drug1": "methadone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Perospirone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with tetracaine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with galanthamine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Isoflurophate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with nitrazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Olopatadine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with quetiapine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with carbamazepine.", "severity": 2}
{"drug1": "ramipril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "benzthiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzthiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with butalbital.", "severity": 2}
{"drug1": "clemastine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with vigabatrin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "propofol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with chlorothiazide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with apraclonidine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with mepivacaine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with clidinium.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with Tasimelteon.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with GUANFACINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Sitaxsentan.", "severity": 2}
{"drug1": "propofol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with sulfasalazine.", "severity": 2}
{"drug1": "biperiden", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with propantheline.", "severity": 2}
{"drug1": "zopiclone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with triflupromazine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Lurasidone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with salicylic acid.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with phenytoin.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Difenoxin.", "severity": 2}
{"drug1": "alprostadil", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprostadil is combined with diflunisal.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "azathioprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with azathioprine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Methyl aminolevulinate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Methyl aminolevulinate.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with glutethimide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "EXEMESTANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with EXEMESTANE.", "severity": 2}
{"drug1": "triazolam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with trandolapril.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Conivaptan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Mometasone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with scopolamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with formoterol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with D-mannitol.", "severity": 2}
{"drug1": "midazolam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with zotepine.", "severity": 2}
{"drug1": "valsartan", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Tolcapone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Nitroprusside.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with dyclonine.", "severity": 2}
{"drug1": "reserpine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with propoxyphene.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Propacetamol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with METAXALONE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Agomelatine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Asenapine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Halazepam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with meclizine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Mirabegron.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with ethanol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Riociguat.", "severity": 2}
{"drug1": "quazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with zotepine.", "severity": 2}
{"drug1": "quazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Paliperidone.", "severity": 2}
{"drug1": "propranolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Nebivolol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Drospirenone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with difluprednate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with mepivacaine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Desloratadine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with halcinonide.", "severity": 2}
{"drug1": "alprenolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprenolol is combined with floctafenine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with dipyridamole.", "severity": 2}
{"drug1": "reserpine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with flunitrazepam.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with imipramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Desloratadine.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Doxercalciferol is combined with Calcifediol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with MELPERONE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with zotepine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Levetiracetam.", "severity": 2}
{"drug1": "Spirapril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with SERATRODAST.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Halobetasol.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with dichlorphenamide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with desipramine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Etomidate.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Pregabalin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Aceclofenac.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with levodopa.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with meperidine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Sacubitril.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with METAXALONE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with chlorprothixene.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with sparfloxacin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with flunitrazepam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with furosemide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "buspirone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with amisulpride.", "severity": 2}
{"drug1": "itraconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with amisulpride.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with oxymorphone.", "severity": 2}
{"drug1": "mebendazole", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mebendazole is combined with metronidazole.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with butamben.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with protriptyline.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with rivastigmine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with cetirizine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with cilazapril.", "severity": 2}
{"drug1": "butamben", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with duloxetine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Metipranolol.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Aliskiren.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Olopatadine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Sacubitril.", "severity": 2}
{"drug1": "ramipril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nadolol.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with duloxetine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with fluoxetine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Amrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Amrubicin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with betamethasone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with furosemide.", "severity": 2}
{"drug1": "barnidipine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with phentolamine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "cocaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with thiamylal.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with metoclopramide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with fluvoxamine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with acemetacin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Olmesartan.", "severity": 2}
{"drug1": "morphine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with topiramate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "morphine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Olmesartan.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with trichlormethiazide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Desloratadine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with meclizine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with risperidone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with timolol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with zaleplon.", "severity": 2}
{"drug1": "meprobamate", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with mepivacaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Tasimelteon.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with dipivefrin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Difenoxin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with dexamethasone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Retigabine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with vigabatrin.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with butorphanol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with tiagabine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with meclofenamic acid.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with ondansetron.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Olopatadine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with etizolam.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Rotigotine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with celecoxib.", "severity": 2}
{"drug1": "primidone", "drug2": "pentobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with pentobarbital.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Icatibant.", "severity": 2}
{"drug1": "tiapride", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with tetracaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with clidinium.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with cinnarizine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with deslanoside.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with salicylic acid.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Bretylium.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "lorazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "reserpine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Clevidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with oxycodone.", "severity": 2}
{"drug1": "morphine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with buspirone.", "severity": 2}
{"drug1": "Articaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with felbamate.", "severity": 2}
{"drug1": "morphine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with fosinopril.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with gabapentin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with triamcinolone.", "severity": 2}
{"drug1": "clonidine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with flunarizine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Pipamperone.", "severity": 2}
{"drug1": "clonidine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "trazodone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Butethal.", "severity": 2}
{"drug1": "trazodone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with lithium ion.", "severity": 2}
{"drug1": "trazodone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Hexobarbital.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "cocaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with dexamethasone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with nimesulide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with hydromorphone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with amitriptyline.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Tolcapone.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Retigabine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with nabumetone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with promethazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Enalaprilat.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with physostigmine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with donepezil.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "anagrelide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with anagrelide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with rivastigmine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when disulfiram is combined with sertraline.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with dorzolamide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with levodopa.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with meperidine.", "severity": 2}
{"drug1": "temazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Gallium nitrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Gallium nitrate.", "severity": 2}
{"drug1": "quazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with NITROUS ACID.", "severity": 2}
{"drug1": "docetaxel", "drug2": "IMIQUIMOD", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "suprofen", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with resveratrol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with homoharringtonine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with galanthamine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with clidinium.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with zonisamide.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with tiagabine.", "severity": 2}
{"drug1": "aspirin", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with acetazolamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with meclizine.", "severity": 2}
{"drug1": "enalapril", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with labetalol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with cocaine.", "severity": 2}
{"drug1": "enalapril", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with AMILORIDE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with flurandrenolide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ambroxol.", "severity": 2}
{"drug1": "enalapril", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with doxazosin.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with lithium ion.", "severity": 2}
{"drug1": "furosemide", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with lisinopril.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with methyclothiazide.", "severity": 2}
{"drug1": "furosemide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with nitroglycerin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with chlorthalidone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "azelastine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with methadone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with olanzapine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Escitalopram.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with tubocurarine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with flunarizine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Tixocortol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with nefazodone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with methocarbamol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with flumethasone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with triprolidine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with nitroglycerin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with promethazine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with lisinopril.", "severity": 2}
{"drug1": "ethotoin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with flunarizine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Perospirone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Ketobemidone.", "severity": 2}
{"drug1": "clindamycin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clindamycin is combined with atorvastatin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with orphenadrine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with galanthamine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Isoflurophate.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with tubocurarine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Fospropofol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with oxycodone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with mecamylamine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with procarbazine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Propoxycaine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Nebivolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Fencamfamin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with tetracaine.", "severity": 2}
{"drug1": "promazine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "promazine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with flunitrazepam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with PAMABROM.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Perospirone.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with carisoprodol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Bretylium.", "severity": 2}
{"drug1": "timolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with penbutolol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with isoproterenol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with prazosin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with lovastatin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with promethazine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Zoledronic acid.", "severity": 2}
{"drug1": "diazepam", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with oxazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with nalbuphine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyridostigmine is combined with acetylcholine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with clonazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nevirapine is combined with oxycodone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Fospropofol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with homoharringtonine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with equilin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Aliskiren.", "severity": 2}
{"drug1": "Salsalate", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with equilin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with isoxsuprine.", "severity": 2}
{"drug1": "azelastine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with flumethasone.", "severity": 2}
{"drug1": "suprofen", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with meclofenamic acid.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Tramadol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with pentazocine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Difenoxin.", "severity": 2}
{"drug1": "suprofen", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with salicylic acid.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with codeine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Apremilast.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with HEROIN.", "severity": 2}
{"drug1": "valsartan", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Levetiracetam.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Normethadone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Risedronic acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with quazepam.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with trichlormethiazide.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Ramelteon.", "severity": 2}
{"drug1": "Normethadone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with triamterene.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with methoxyflurane.", "severity": 2}
{"drug1": "tioconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with eperisone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with teniposide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Agomelatine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with chloramphenicol.", "severity": 2}
{"drug1": "clemastine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Milnacipran.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with desipramine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Risedronic acid.", "severity": 2}
{"drug1": "nabumetone", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with suprofen.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ethotoin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with tretinoin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Articaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Normethadone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with propofol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with prednisone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with astemizole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Clofarabine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "prazosin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with cilazapril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with tetracaine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with tiapride.", "severity": 2}
{"drug1": "zotepine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with carisoprodol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Droxicam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with ritodrine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with D-mannitol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with clonidine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with scopolamine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with felbamate.", "severity": 2}
{"drug1": "loxapine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with MOLINDONE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with clidinium.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "timolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Clevidipine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with oxprenolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with cilazapril.", "severity": 2}
{"drug1": "lisinopril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with papaverine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with prazepam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with propoxyphene.", "severity": 2}
{"drug1": "anagrelide", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with aspirin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with dyclonine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with nifedipine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with halothane.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Bretylium.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with SUFENTANIL.", "severity": 2}
{"drug1": "amifostine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Clevidipine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with duloxetine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with IDARUBICIN.", "severity": 2}
{"drug1": "apomorphine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with propofol.", "severity": 2}
{"drug1": "sulindac", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with methylprednisolone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with dexamethasone.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Boceprevir is combined with Abemaciclib.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with clidinium.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with enalapril.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with clidinium.", "severity": 2}
{"drug1": "metoprolol", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with trandolapril.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with methyldopa.", "severity": 2}
{"drug1": "nimesulide", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with equilin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Loxoprofen.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Tolcapone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Normethadone.", "severity": 2}
{"drug1": "glutethimide", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with amitriptyline.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Milnacipran.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with apraclonidine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with glutethimide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Telmisartan.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with niflumic acid.", "severity": 2}
{"drug1": "ketamine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Melatonin.", "severity": 2}
{"drug1": "ketamine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with clonazepam.", "severity": 2}
{"drug1": "ketamine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with promethazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with baclofen.", "severity": 2}
{"drug1": "Spirapril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with chloroquine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Arformoterol.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Tasimelteon.", "severity": 2}
{"drug1": "doxylamine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with nefazodone.", "severity": 2}
{"drug1": "midazolam", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with levorphanol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with orphenadrine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with sulindac.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with paroxetine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "metolazone", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with digoxin.", "severity": 2}
{"drug1": "metolazone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with sulpiride.", "severity": 2}
{"drug1": "carvedilol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with cilazapril.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with apraclonidine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Cis-mdp.", "severity": 2}
{"drug1": "triazolam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with DEZOCINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Apremilast.", "severity": 2}
{"drug1": "triazolam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Levetiracetam.", "severity": 2}
{"drug1": "Icatibant", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with zaltoprofen.", "severity": 2}
{"drug1": "Normethadone", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with procarbazine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Pipotiazine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "carprofen", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with mycophenolic acid.", "severity": 2}
{"drug1": "tiapride", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with desipramine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with nimesulide.", "severity": 2}
{"drug1": "procaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with topiramate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with olanzapine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with chlorprothixene.", "severity": 2}
{"drug1": "risperidone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Aripiprazole.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Fencamfamin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with azelastine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with fosinopril.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with tetracaine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with dantrolene.", "severity": 2}
{"drug1": "medrysone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "loxapine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Milnacipran.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ketoprofen.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with METAXALONE.", "severity": 2}
{"drug1": "bepridil", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with nitric oxide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Pipamperone.", "severity": 2}
{"drug1": "tioconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with isradipine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with clomipramine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with sulfasalazine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nitroglycerin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with trimipramine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with equilin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with lisinopril.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Aliskiren.", "severity": 2}
{"drug1": "resveratrol", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with alclofenac.", "severity": 2}
{"drug1": "flurazepam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with pimozide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with nisoldipine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with sertraline.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with budesonide.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with ketorolac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with acebutolol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with nabumetone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with ambenonium.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with clidinium.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with tenoxicam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with maprotiline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ACENOCOUMAROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "butamben", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Iloperidone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with carisoprodol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with protriptyline.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with paramethasone.", "severity": 2}
{"drug1": "meperidine", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with tubocurarine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with tiapride.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with fluoxetine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Retigabine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with levorphanol.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with duloxetine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with bepridil.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with sertraline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Estrone sulfate.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with clidinium.", "severity": 2}
{"drug1": "halothane", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Fluspirilene.", "severity": 2}
{"drug1": "halothane", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with flunarizine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with DEZOCINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Desloratadine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with apraclonidine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with DESFLURANE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with dichlorphenamide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with propofol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with bupropion.", "severity": 2}
{"drug1": "apomorphine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with triamterene.", "severity": 2}
{"drug1": "terbutaline", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Levetiracetam.", "severity": 2}
{"drug1": "timolol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with triamterene.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with alclofenac.", "severity": 2}
{"drug1": "temazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with ondansetron.", "severity": 2}
{"drug1": "temazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with tiagabine.", "severity": 2}
{"drug1": "temazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with cocaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "pentamidine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with gabapentin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with mesoridazine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with maprotiline.", "severity": 2}
{"drug1": "temazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with zonisamide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with HEROIN.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Asenapine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with Isoflurophate.", "severity": 2}
{"drug1": "morphine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with METAXALONE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with etizolam.", "severity": 2}
{"drug1": "pergolide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Iloperidone.", "severity": 2}
{"drug1": "Trometamol", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trometamol is combined with misoprostol.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Remoxipride.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with loxapine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with prazosin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with decamethonium.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Spirapril.", "severity": 2}
{"drug1": "pergolide", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with topiramate.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with clonidine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with methyldopa.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with venlafaxine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with vigabatrin.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with nitrendipine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with clonazepam.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextroamphetamine is combined with selegiline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with methazolamide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Ethylmorphine.", "severity": 2}
{"drug1": "sotalol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with methazolamide.", "severity": 2}
{"drug1": "isradipine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Eprosartan.", "severity": 2}
{"drug1": "pergolide", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with metyrapone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Ciclesonide.", "severity": 2}
{"drug1": "methadone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Agomelatine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with sparfloxacin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with GUANFACINE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with xylometazoline.", "severity": 2}
{"drug1": "Micafungin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with gabapentin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with quinapril.", "severity": 2}
{"drug1": "methazolamide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with chlorothiazide.", "severity": 2}
{"drug1": "methazolamide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with bumetanide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with topiramate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Lormetazepam.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with clomipramine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Icatibant.", "severity": 2}
{"drug1": "proparacaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "morphine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "acemetacin", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with flumethasone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with methazolamide.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with oxycodone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Efonidipine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with isoxsuprine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with thiopental.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Risedronic acid.", "severity": 2}
{"drug1": "methylene blue", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with terbutaline.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Estrone sulfate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with cocaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with betamethasone.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with nicardipine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ACENOCOUMAROL is combined with Nintedanib.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Etoricoxib.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with flunarizine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with chloral hydrate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Milnacipran.", "severity": 2}
{"drug1": "butabarbital", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with diphenhydramine.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Difenoxin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Retigabine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Pizotifen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ethotoin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with tretinoin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with prilocaine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with irbesartan.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with flurandrenolide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with felodipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with apraclonidine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "colchicine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with colchicine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Lofexidine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "meperidine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Ketobemidone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with atorvastatin.", "severity": 2}
{"drug1": "valsartan", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with fenoprofen.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with morphine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with chlorzoxazone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with rivastigmine.", "severity": 2}
{"drug1": "terconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with flunarizine.", "severity": 2}
{"drug1": "enflurane", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with clonidine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with CLONIXIN.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with fexofenadine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with risperidone.", "severity": 2}
{"drug1": "bifonazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with cilnidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Iloperidone.", "severity": 2}
{"drug1": "morphine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Canagliflozin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with nadolol.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Naftifine.", "severity": 2}
{"drug1": "imipramine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with metaproterenol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with clonidine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with flumethasone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with methazolamide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Eplerenone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Levalbuterol.", "severity": 2}
{"drug1": "benazepril", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with nitroglycerin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with NICORANDIL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with methadone.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Mirabegron.", "severity": 2}
{"drug1": "propranolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "butamben", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with levodopa.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with dipyridamole.", "severity": 2}
{"drug1": "trazodone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with halothane.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with NAPROXEN.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with levorphanol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "zaleplon", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with citalopram.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with tetracaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with mitoxantrone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "trazodone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Etidocaine.", "severity": 2}
{"drug1": "butamben", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with trimipramine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Pomalidomide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "linezolid", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with reserpine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with buprenorphine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with lomustine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Nebivolol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with bicalutamide.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with PERHEXILINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with clidinium.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with meclizine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Lorcaserin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with trazodone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with brimonidine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with vinorelbine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with flunitrazepam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nifedipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with sotalol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with papaverine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with clonidine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with sulfanilamide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "quazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with dibucaine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with desipramine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with protriptyline.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with cinnarizine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with methocarbamol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with halothane.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Bretylium.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with triprolidine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with thiamylal.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with GUANFACINE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with citalopram.", "severity": 2}
{"drug1": "selegiline", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with triflupromazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with nitrendipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with triazolam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Levetiracetam.", "severity": 2}
{"drug1": "tretinoin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with captopril.", "severity": 2}
{"drug1": "meperidine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ethosuximide.", "severity": 2}
{"drug1": "epirizole", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with DESONIDE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with acebutolol.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Escitalopram.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with orphenadrine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Retigabine.", "severity": 2}
{"drug1": "methadone", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with dextromethorphan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "gabapentin", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cilastatin is combined with Temsirolimus.", "severity": 2}
{"drug1": "celecoxib", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Tixocortol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with tizanidine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Difenoxin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with acemetacin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Fencamfamin.", "severity": 2}
{"drug1": "Retigabine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with venlafaxine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Ethylmorphine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with quetiapine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Escitalopram.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with ethosuximide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with atorvastatin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with formestane.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with thiopental.", "severity": 2}
{"drug1": "antipyrine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with formestane.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with loxapine.", "severity": 2}
{"drug1": "prazosin", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with clonidine.", "severity": 2}
{"drug1": "benazepril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with nadolol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with meperidine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with MELPERONE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with zotepine.", "severity": 2}
{"drug1": "trazodone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with desipramine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with xylometazoline.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tolazoline.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with sulfasalazine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with spironolactone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with mepivacaine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Droxicam.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Aliskiren.", "severity": 2}
{"drug1": "trazodone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Oxetacaine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with dipyridamole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with levodopa.", "severity": 2}
{"drug1": "diflunisal", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with oxaprozin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with sulindac.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with cetirizine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with triflupromazine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with betamethasone.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with flunarizine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Clevidipine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Levetiracetam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with haloperidol.", "severity": 2}
{"drug1": "meperidine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with oxprenolol.", "severity": 2}
{"drug1": "prazosin", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Canagliflozin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with trazodone.", "severity": 2}
{"drug1": "methysergide", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with fluvoxamine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Estrone sulfate.", "severity": 2}
{"drug1": "methysergide", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with pravastatin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Masoprocol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with AMILORIDE.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with diphenhydramine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Tasimelteon.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with nortriptyline.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "stavudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with stavudine.", "severity": 2}
{"drug1": "codeine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Lormetazepam.", "severity": 2}
{"drug1": "suprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Halobetasol.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Retigabine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with atorvastatin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Perospirone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with trandolapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with mesalamine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Treprostinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Treprostinil.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with baclofen.", "severity": 2}
{"drug1": "Articaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "dapsone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with prilocaine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Lornoxicam.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Asenapine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with ethanol.", "severity": 2}
{"drug1": "midazolam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with thiamylal.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with azelastine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nitric oxide.", "severity": 2}
{"drug1": "metronidazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metronidazole is combined with atorvastatin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with methocarbamol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Etidocaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with mecamylamine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with triprolidine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Bambuterol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Mometasone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with clidinium.", "severity": 2}
{"drug1": "mesalamine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with difluprednate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Efonidipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Lacidipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Benidipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Azelnidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with clonazepam.", "severity": 2}
{"drug1": "morphine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with promethazine.", "severity": 2}
{"drug1": "felodipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with cilazapril.", "severity": 2}
{"drug1": "morphine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Melatonin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with quetiapine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Tasimelteon.", "severity": 2}
{"drug1": "diazepam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with aspirin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with methyclothiazide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Asenapine.", "severity": 2}
{"drug1": "buspirone", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with pimozide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with triamterene.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "buspirone", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Thioproperazine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Olopatadine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Pipotiazine.", "severity": 2}
{"drug1": "estrone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with galanthamine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Cis-mdp.", "severity": 2}
{"drug1": "estrone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Isoflurophate.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Tolcapone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with oxymorphone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with amitriptyline.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with papaverine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with zopiclone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with edrophonium.", "severity": 2}
{"drug1": "atenolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Riociguat.", "severity": 2}
{"drug1": "olanzapine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with methyclothiazide.", "severity": 2}
{"drug1": "meperidine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with brotizolam.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ticlopidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with ticlopidine.", "severity": 2}
{"drug1": "eperisone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with methocarbamol.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "losartan", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with nifedipine.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "didanosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with didanosine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "losartan", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with papaverine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Clevidipine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with isradipine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with MOLINDONE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Pipamperone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "hexetidine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "benztropine", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Trospium.", "severity": 2}
{"drug1": "nadolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 6-Mercaptopurine is combined with leflunomide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with metoprolol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ropinirole.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with felbamate.", "severity": 2}
{"drug1": "HEROIN", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with indapamide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with ibuprofen.", "severity": 2}
{"drug1": "phenytoin", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with meclizine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "trazodone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Olopatadine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Lormetazepam.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with memantine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SAQUINAVIR is combined with efavirenz.", "severity": 2}
{"drug1": "butamben", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with efavirenz.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with rasagiline.", "severity": 2}
{"drug1": "terconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with CLONIXIN.", "severity": 2}
{"drug1": "quazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with protriptyline.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with flumethasone.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Spectinomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Spectinomycin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Butethal.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with NICORANDIL.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Halazepam.", "severity": 2}
{"drug1": "halothane", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with tretinoin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Normethadone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Lormetazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Lurasidone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Phenelzine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with trifluoperazine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with pravastatin.", "severity": 2}
{"drug1": "enflurane", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with benzyl alcohol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with vigabatrin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with acebutolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with captopril.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with selegiline.", "severity": 2}
{"drug1": "reserpine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Articaine.", "severity": 2}
{"drug1": "tiapride", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with baclofen.", "severity": 2}
{"drug1": "moclobemide", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with SERTINDOLE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Clevidipine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with quinidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with oxaprozin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with malathion.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Tolvaptan.", "severity": 2}
{"drug1": "meperidine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "reserpine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with METAXALONE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with clonidine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Estrone sulfate.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with diazoxide.", "severity": 2}
{"drug1": "carprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with clomipramine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with cilazapril.", "severity": 2}
{"drug1": "azelastine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with flurandrenolide.", "severity": 2}
{"drug1": "disulfiram", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when disulfiram is combined with isoniazid.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with carvedilol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Escitalopram.", "severity": 2}
{"drug1": "methysergide", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Repaglinide.", "severity": 2}
{"drug1": "butalbital", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Escitalopram.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with clidinium.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Flibanserin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with tiagabine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with nitrendipine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with chlorprothixene.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Aripiprazole.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with rizatriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with naratriptan.", "severity": 2}
{"drug1": "oxycodone", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with sevoflurane.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Desloratadine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Canagliflozin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Vapreotide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Vapreotide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Apremilast.", "severity": 2}
{"drug1": "furosemide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with bumetanide.", "severity": 2}
{"drug1": "azelastine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with baclofen.", "severity": 2}
{"drug1": "furosemide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Halobetasol.", "severity": 2}
{"drug1": "furosemide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with quinapril.", "severity": 2}
{"drug1": "furosemide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with chlorothiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with enoxacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with NAPROXEN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with mefenamic acid.", "severity": 2}
{"drug1": "rasagiline", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with quetiapine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with raloxifene.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with ethotoin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with penbutolol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with METAXALONE.", "severity": 2}
{"drug1": "trazodone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with doxepin.", "severity": 2}
{"drug1": "temazepam", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with diazepam.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Mometasone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "oxycodone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with oxprenolol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Bretylium.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Efonidipine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with quazepam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with prazepam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Salsalate", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with methylprednisolone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with isoflurane.", "severity": 2}
{"drug1": "propofol", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with diazepam.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with citalopram.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "LYCOPENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with LYCOPENE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with fexofenadine.", "severity": 2}
{"drug1": "morphine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with desipramine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Flibanserin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "estazolam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with dantrolene.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nitric oxide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "timolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Propacetamol.", "severity": 2}
{"drug1": "tetracaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with nefazodone.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with nimesulide.", "severity": 2}
{"drug1": "aspirin", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with oxaprozin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with scopolamine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with doxepin.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Pefloxacin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with estrone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with chlormezanone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with medrysone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with levodopa.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Escitalopram.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with tiapride.", "severity": 2}
{"drug1": "Varenicline", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Varenicline is combined with ethanol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Clofarabine.", "severity": 2}
{"drug1": "codeine", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Alvimopan.", "severity": 2}
{"drug1": "apomorphine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with fexofenadine.", "severity": 2}
{"drug1": "methysergide", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "imipramine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Levocetirizine.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Pitavastatin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with brotizolam.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with memantine.", "severity": 2}
{"drug1": "aspirin", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with flumethasone.", "severity": 2}
{"drug1": "azelastine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with atorvastatin.", "severity": 2}
{"drug1": "clonidine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with loratadine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with SERATRODAST.", "severity": 2}
{"drug1": "Nabilone", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with meclizine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with mesoridazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with maprotiline.", "severity": 2}
{"drug1": "Nabilone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with furosemide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with carvedilol.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Pinaverium.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Zoledronic acid.", "severity": 2}
{"drug1": "prilocaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with flunarizine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with lithium ion.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with cilnidipine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Remoxipride.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with loxapine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with cilazapril.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with oxprenolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with Spirapril.", "severity": 2}
{"drug1": "alclofenac", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with tetracaine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with etizolam.", "severity": 2}
{"drug1": "indapamide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with apraclonidine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Olopatadine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with thioridazine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "procyclidine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with morphine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Mometasone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with citalopram.", "severity": 2}
{"drug1": "methadone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Butethal.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Ethylmorphine.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when erythromycin is combined with Temsirolimus.", "severity": 2}
{"drug1": "Articaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with clidinium.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with metoprolol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Perospirone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Fencamfamin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Ramelteon.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Methadyl acetate.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with nitric oxide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with glutethimide.", "severity": 2}
{"drug1": "midazolam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with cetirizine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with metoclopramide.", "severity": 2}
{"drug1": "temazepam", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with oxycodone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with butamben.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with chlorprothixene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with clonazepam.", "severity": 2}
{"drug1": "midazolam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Pipotiazine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with mecamylamine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "methadone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with maprotiline.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with protriptyline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "buspirone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Articaine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with methyldopa.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Normethadone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Cyamemazine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Loxoprofen.", "severity": 2}
{"drug1": "miconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with gabapentin.", "severity": 2}
{"drug1": "temazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with HEROIN.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with protriptyline.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with flunisolide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NEOSTIGMINE is combined with methacholine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with acetazolamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Clevidipine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with diclofenac.", "severity": 2}
{"drug1": "fosinopril", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with enalapril.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "azelastine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with mecamylamine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Pizotifen.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with labetalol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with citalopram.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Abemaciclib.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Aliskiren.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with nifedipine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Bambuterol.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with DESONIDE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Amrinone.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "clidinium", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Milnacipran.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "ropinirole", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with isoxsuprine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with metoprolol.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with baclofen.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "caffeine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when caffeine is combined with Indacaterol.", "severity": 2}
{"drug1": "procaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Melatonin.", "severity": 2}
{"drug1": "Micafungin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with nilvadipine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with amoxapine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with GUANFACINE.", "severity": 2}
{"drug1": "procaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with promethazine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Tolcapone.", "severity": 2}
{"drug1": "temazepam", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with hydromorphone.", "severity": 2}
{"drug1": "temazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with meclofenamic acid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with ethotoin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Etoricoxib.", "severity": 2}
{"drug1": "Salsalate", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with dexamethasone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Thioproperazine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Metixene.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with flunitrazepam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with HEROIN.", "severity": 2}
{"drug1": "codeine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with bromazepam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Mephobarbital.", "severity": 2}
{"drug1": "codeine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with DEZOCINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Fluspirilene.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Agomelatine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with sumatriptan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with tizanidine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with trimipramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with chlorothiazide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with quinapril.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with methylene blue.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Toloxatone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Pirlindole.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Aceprometazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with butamben.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with MOLINDONE.", "severity": 2}
{"drug1": "quinidine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with oxybutynin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with carvedilol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with phenobarbital.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with ILOPROST.", "severity": 2}
{"drug1": "suprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with acemetacin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with mesoridazine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with edrophonium.", "severity": 2}
{"drug1": "ketamine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with brotizolam.", "severity": 2}
{"drug1": "quinapril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with meperidine.", "severity": 2}
{"drug1": "captopril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with meperidine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "propantheline", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with tubocurarine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Bretylium.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with doxepin.", "severity": 2}
{"drug1": "halothane", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with glutethimide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Bambuterol.", "severity": 2}
{"drug1": "ramipril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "halothane", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Methadyl acetate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with meclizine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with methocarbamol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Agomelatine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with spironolactone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with triprolidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with dibucaine.", "severity": 2}
{"drug1": "ketamine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with trimipramine.", "severity": 2}
{"drug1": "ketamine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with procaine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Fosphenytoin.", "severity": 2}
{"drug1": "propofol", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with prazosin.", "severity": 2}
{"drug1": "propofol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with loratadine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with desoximetasone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with fenoprofen.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with alclofenac.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with HYDROCODONE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with hydralazine.", "severity": 2}
{"drug1": "citalopram", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Darunavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "bupropion", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupropion is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with enoxacin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Phenelzine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with clenbuterol.", "severity": 2}
{"drug1": "miconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with galanthamine.", "severity": 2}
{"drug1": "felbamate", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Milnacipran.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with triamterene.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with loratadine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Retigabine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with imipramine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ramipril", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with sotalol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with fexofenadine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with trazodone.", "severity": 2}
{"drug1": "ramipril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with celecoxib.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "dyclonine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with butalbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with zotepine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with dyclonine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with methadone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "butenafine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Lercanidipine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Mephobarbital.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "metolazone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with terazosin.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with captopril.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Drospirenone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with promethazine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with acebutolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with irbesartan.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with tolazoline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with maprotiline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Mephobarbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chloral hydrate.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Desloratadine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with NICORANDIL.", "severity": 2}
{"drug1": "glutethimide", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with fludiazepam.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with promethazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with clonazepam.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with isoxsuprine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with carprofen.", "severity": 2}
{"drug1": "estrone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "halothane", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with scopolamine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with promethazine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with clonazepam.", "severity": 2}
{"drug1": "halothane", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with D-mannitol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with reserpine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Flibanserin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with propofol.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with flunarizine.", "severity": 2}
{"drug1": "estazolam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with vigabatrin.", "severity": 2}
{"drug1": "estazolam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with benzocaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Difenoxin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with bumetanide.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Flibanserin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Mephobarbital.", "severity": 2}
{"drug1": "meperidine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with maprotiline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Ketobemidone.", "severity": 2}
{"drug1": "epinastine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with diflunisal.", "severity": 2}
{"drug1": "estrone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with memantine.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Pomalidomide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Olmesartan.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with chlorothiazide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with efavirenz.", "severity": 2}
{"drug1": "clorazepate", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with nitrous oxide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with minoxidil.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with quinapril.", "severity": 2}
{"drug1": "phentolamine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with nifedipine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Lormetazepam.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Propacetamol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with gabapentin.", "severity": 2}
{"drug1": "estazolam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with irbesartan.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with ethosuximide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with dantrolene.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Salmeterol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with diflorasone.", "severity": 2}
{"drug1": "propofol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with zotepine.", "severity": 2}
{"drug1": "propofol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with MELPERONE.", "severity": 2}
{"drug1": "loratadine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "celecoxib", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with nitrazepam.", "severity": 2}
{"drug1": "estradiol", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estradiol is combined with Ospemifene.", "severity": 2}
{"drug1": "celecoxib", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with amcinonide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with nimesulide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Normethadone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with mesalamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Tolvaptan.", "severity": 2}
{"drug1": "diclofenac", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with alclometasone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with ramipril.", "severity": 2}
{"drug1": "apomorphine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with valsartan.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Fluprednidene.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "enflurane", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Fospropofol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with tolazoline.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with ambenonium.", "severity": 2}
{"drug1": "miconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "eperisone", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with lovastatin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Olopatadine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with butalbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with METAXALONE.", "severity": 2}
{"drug1": "temazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "meperidine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with zonisamide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with brotizolam.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "meperidine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "gabapentin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with citalopram.", "severity": 2}
{"drug1": "meperidine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with tiagabine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with bumetanide.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Flibanserin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Etidronic acid.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with diphenhydramine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "captopril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Oxetacaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with clidinium.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Ramelteon.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with sevoflurane.", "severity": 2}
{"drug1": "Trospium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Tramadol.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with diclofenac.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Propiverine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with niflumic acid.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Potassium citrate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Retigabine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Salmeterol.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with terazosin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Etidocaine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with ethosuximide.", "severity": 2}
{"drug1": "clozapine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nalbuphine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with equilin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with sevoflurane.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with resveratrol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Butethal", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with brotizolam.", "severity": 2}
{"drug1": "amiodarone", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with MOXONIDINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with meclizine.", "severity": 2}
{"drug1": "morphine", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with cyclothiazide.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Canagliflozin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with cilazapril.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with atenolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Levobupivacaine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Etidocaine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "butamben", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with chlorzoxazone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Etidronic acid.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Lumiracoxib.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with oxprenolol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with prilocaine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with olanzapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with atenolol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with estazolam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with leflunomide.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with nefazodone.", "severity": 2}
{"drug1": "enalapril", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with methazolamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with methadone.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with bepridil.", "severity": 2}
{"drug1": "cetirizine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with clidinium.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Etidocaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with dantrolene.", "severity": 2}
{"drug1": "minoxidil", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with bumetanide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with ketamine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with methyclothiazide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Nabilone.", "severity": 2}
{"drug1": "temazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with halothane.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with brimonidine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with clidinium.", "severity": 2}
{"drug1": "temazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with thiamylal.", "severity": 2}
{"drug1": "sulindac", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with nimesulide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with sotalol.", "severity": 2}
{"drug1": "temazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with desipramine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "triprolidine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with efavirenz.", "severity": 2}
{"drug1": "bromopride", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromopride is combined with sulpiride.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Arbekacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Arbekacin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with carisoprodol.", "severity": 2}
{"drug1": "sulindac", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Cis-mdp.", "severity": 2}
{"drug1": "clorazepate", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with sulpiride.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with sertraline.", "severity": 2}
{"drug1": "risperidone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "benazepril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "risperidone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with tiapride.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with quetiapine.", "severity": 2}
{"drug1": "Trospium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Ketobemidone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with triprolidine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with methocarbamol.", "severity": 2}
{"drug1": "epirizole", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with sertraline.", "severity": 2}
{"drug1": "epirizole", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with paramethasone.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Methadyl acetate.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nicardipine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with tolmetin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Pomalidomide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Fencamfamin.", "severity": 2}
{"drug1": "quazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with clomipramine.", "severity": 2}
{"drug1": "midodrine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "thioridazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Metipranolol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "benazepril", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with dipyridamole.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with scopolamine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Apremilast.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with D-mannitol.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Difenoxin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "irbesartan", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with epirizole.", "severity": 2}
{"drug1": "butorphanol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with glutethimide.", "severity": 2}
{"drug1": "pergolide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with efavirenz.", "severity": 2}
{"drug1": "pergolide", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with testosterone.", "severity": 2}
{"drug1": "pergolide", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with nicardipine.", "severity": 2}
{"drug1": "pimozide", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with mesoridazine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with clonazepam.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Azelnidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with gabapentin.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Efonidipine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Lacidipine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with fluvoxamine.", "severity": 2}
{"drug1": "reserpine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with chloral hydrate.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Olopatadine.", "severity": 2}
{"drug1": "promazine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with rasagiline.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Propacetamol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "methylergonovine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with methylergonovine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Retigabine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with mefloquine.", "severity": 2}
{"drug1": "terazosin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with indapamide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with furosemide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with sulpiride.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with tizanidine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Masoprocol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with metaproterenol.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with buprenorphine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Olmesartan.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with isradipine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Estrone sulfate.", "severity": 2}
{"drug1": "chloroxine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with nilvadipine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Etidronic acid.", "severity": 2}
{"drug1": "resveratrol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with atorvastatin.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "sulpiride", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with doxepin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with benzocaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Escitalopram.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "selegiline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with moclobemide.", "severity": 2}
{"drug1": "propranolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Clevidipine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with felbamate.", "severity": 2}
{"drug1": "Triflusal", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "prazosin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with GUANFACINE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with citalopram.", "severity": 2}
{"drug1": "barnidipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with midazolam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "meperidine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "sulindac", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with hydrocortisone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Eplerenone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with vigabatrin.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with levorphanol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with theobromine.", "severity": 2}
{"drug1": "reserpine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with methoxyflurane.", "severity": 2}
{"drug1": "reserpine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with irbesartan.", "severity": 2}
{"drug1": "Apremilast", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with DESONIDE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with benzocaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with felodipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with chlorzoxazone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with vigabatrin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Fosphenytoin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Escitalopram.", "severity": 2}
{"drug1": "reserpine", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with meprobamate.", "severity": 2}
{"drug1": "celecoxib", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with oxaprozin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Pipamperone.", "severity": 2}
{"drug1": "estazolam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with efavirenz.", "severity": 2}
{"drug1": "buspirone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with enflurane.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with venlafaxine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with clemastine.", "severity": 2}
{"drug1": "piracetam", "drug2": "liothyronine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when piracetam is combined with liothyronine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with oxprenolol.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with zotepine.", "severity": 2}
{"drug1": "promazine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with tranylcypromine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "promazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with ethotoin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with pilocarpine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with sulpiride.", "severity": 2}
{"drug1": "aspirin", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with NICORANDIL.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with phenytoin.", "severity": 2}
{"drug1": "ketamine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "aspirin", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with haloperidol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with decamethonium.", "severity": 2}
{"drug1": "lorazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with butalbital.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with cinoxacin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with nitrazepam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Tolcapone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with amitriptyline.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Fencamfamin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with flunitrazepam.", "severity": 2}
{"drug1": "enalapril", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with chlorothiazide.", "severity": 2}
{"drug1": "enalapril", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with quinapril.", "severity": 2}
{"drug1": "enalapril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with bumetanide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with butorphanol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Olopatadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with baclofen.", "severity": 2}
{"drug1": "diazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with celecoxib.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with desipramine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "fosinopril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with cilazapril.", "severity": 2}
{"drug1": "haloperidol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with fludiazepam.", "severity": 2}
{"drug1": "tropicamide", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with cyclopentolate.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Bretylium.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with HEROIN.", "severity": 2}
{"drug1": "trazodone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with tiapride.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with oxprenolol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Empagliflozin.", "severity": 2}
{"drug1": "buspirone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Dapagliflozin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with oxazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with nalbuphine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Mephobarbital.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with ethotoin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Normethadone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Escitalopram.", "severity": 2}
{"drug1": "olanzapine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with prilocaine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with loratadine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Iloperidone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with AMILORIDE.", "severity": 2}
{"drug1": "morphine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Lormetazepam.", "severity": 2}
{"drug1": "methysergide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with methazolamide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with fosinopril.", "severity": 2}
{"drug1": "clidinium", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with desipramine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with triflupromazine.", "severity": 2}
{"drug1": "valsartan", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "methysergide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with atorvastatin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "methysergide", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with mequitazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Atazanavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Atazanavir.", "severity": 2}
{"drug1": "methadone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Indacaterol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with zopiclone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Eplerenone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with D-mannitol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with D-mannitol.", "severity": 2}
{"drug1": "methadone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with tiagabine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with furosemide.", "severity": 2}
{"drug1": "enalapril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with leflunomide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with diazepam.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Micafungin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with felodipine.", "severity": 2}
{"drug1": "enflurane", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with chloral hydrate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with etizolam.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nifedipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Agomelatine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "phenindione", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenindione is combined with Deferasirox.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with vigabatrin.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Articaine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Olopatadine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Articaine.", "severity": 2}
{"drug1": "dapsone", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Spirapril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with suprofen.", "severity": 2}
{"drug1": "morphine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with dantrolene.", "severity": 2}
{"drug1": "benazepril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "morphine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with estazolam.", "severity": 2}
{"drug1": "morphine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Metipranolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Ropivacaine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with GUANFACINE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with zonisamide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with niflumic acid.", "severity": 2}
{"drug1": "terazosin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with captopril.", "severity": 2}
{"drug1": "lorazepam", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with oxazepam.", "severity": 2}
{"drug1": "pramipexole", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with selegiline.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aluminium hydroxide is combined with misoprostol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "procaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with imipramine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Propoxycaine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Pramocaine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Deferasirox.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with risperidone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with flumethasone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with medrysone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with ramipril.", "severity": 2}
{"drug1": "duloxetine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with rizatriptan.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with paramethasone.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with barnidipine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with enflurane.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with metoclopramide.", "severity": 2}
{"drug1": "etizolam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with trimipramine.", "severity": 2}
{"drug1": "tiapride", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with carisoprodol.", "severity": 2}
{"drug1": "tiapride", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with sulpiride.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Tolcapone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "epinastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with epinastine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with zolmitriptan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with tiagabine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with salicylic acid.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Butethal", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with clomipramine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Halobetasol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Lormetazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with methylene blue.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Toloxatone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Pirlindole.", "severity": 2}
{"drug1": "stavudine", "drug2": "didanosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when stavudine is combined with didanosine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with duloxetine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Metixene.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with fluoxetine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Normethadone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Desloratadine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with furosemide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with tizanidine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumefantrine is combined with dapsone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Asenapine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with butalbital.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with butamben.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with cilazapril.", "severity": 2}
{"drug1": "proparacaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with nefazodone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with acemetacin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nilotinib is combined with clozapine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with doxepin.", "severity": 2}
{"drug1": "diazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with halothane.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Salmeterol.", "severity": 2}
{"drug1": "papaverine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with penbutolol.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Retigabine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with MOLINDONE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "citalopram", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with thiamylal.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Cis-mdp.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Riociguat.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with halothane.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Normethadone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ketamine.", "severity": 2}
{"drug1": "diazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with desipramine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with perphenazine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with levorphanol.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with nefazodone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with amoxapine.", "severity": 2}
{"drug1": "epirizole", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with acemetacin.", "severity": 2}
{"drug1": "pancuronium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with buprenorphine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with periciazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with terazosin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with doxepin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Thioproperazine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Lormetazepam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ifosfamide.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Pramocaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "moxifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with moxifloxacin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with sertraline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Methadyl acetate.", "severity": 2}
{"drug1": "doxepin", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with ritodrine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with perphenazine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Canrenoic acid.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Iloperidone.", "severity": 2}
{"drug1": "glyburide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glyburide is combined with atorvastatin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with methyclothiazide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with haloperidol.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Butylscopolamine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with thioridazine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with methylprednisolone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with felbamate.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Pipamperone.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with hyoscyamine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with indapamide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with desipramine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Halobetasol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with clomipramine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with alclometasone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ALFENTANIL.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Halazepam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with proparacaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with indapamide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with levodopa.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with celiprolol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with felodipine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with aspirin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Clobetasone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Pipotiazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with mesoridazine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with maprotiline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with topiramate.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with promethazine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with clonazepam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Olmesartan.", "severity": 2}
{"drug1": "losartan", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with diflunisal.", "severity": 2}
{"drug1": "trandolapril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with flurbiprofen.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with felodipine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with fludiazepam.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with halcinonide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with fenbufen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with difluprednate.", "severity": 2}
{"drug1": "nimesulide", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Lormetazepam.", "severity": 2}
{"drug1": "loratadine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with ethosuximide.", "severity": 2}
{"drug1": "carprofen", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Nabilone", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with paroxetine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with chloral hydrate.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Pipamperone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Flibanserin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with scopolamine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with orphenadrine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with Olsalazine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Naftifine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Fluprednidene.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with digoxin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with sulpiride.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nisoldipine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "bepridil", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Benidipine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with nalidixic acid.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Oxetacaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "meperidine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with MOLINDONE.", "severity": 2}
{"drug1": "sotalol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Clevidipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with hydralazine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with mesalamine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with nalidixic acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with alclometasone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nicardipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with codeine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with malathion.", "severity": 2}
{"drug1": "loxapine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with pimozide.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "codeine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Retigabine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with thiopental.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with triazolam.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with HEROIN.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with ethosuximide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with phenytoin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Clodronic Acid.", "severity": 2}
{"drug1": "tolterodine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with buprenorphine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with levodopa.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with sevoflurane.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Metixene", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with hydromorphone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Olopatadine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Clobetasone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with cyclophosphamide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Aripiprazole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with chlorprothixene.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ATROPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with ATROPINE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Pomalidomide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with sulfasalazine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Tolcapone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Halazepam.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with fluocinonide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with carisoprodol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with sulpiride.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Lormetazepam.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with betamethasone.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Lormetazepam.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Desloratadine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Levocetirizine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Fluspirilene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with methocarbamol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with triflupromazine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Perospirone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with triprolidine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with flumethasone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Torasemide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with rasagiline.", "severity": 2}
{"drug1": "losartan", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with lisinopril.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Icatibant.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Milnacipran.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with methocarbamol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with SERATRODAST.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with triprolidine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with zaltoprofen.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Escitalopram.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with methylprednisolone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Cyamemazine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with CLONIXIN.", "severity": 2}
{"drug1": "quinidine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with HEROIN.", "severity": 2}
{"drug1": "valsartan", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with hydralazine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "methoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with methoxamine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Loxoprofen.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with oxprenolol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with leflunomide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Tasimelteon.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with prazepam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with quetiapine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with D-mannitol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with methyclothiazide.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PSEUDOEPHEDRINE is combined with procarbazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with PROCATEROL.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with flunarizine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Empagliflozin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with mepivacaine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ethchlorvynol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with niflumic acid.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with ESMOLOL.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with fludrocortisone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with baclofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with amcinonide.", "severity": 2}
{"drug1": "loxapine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Olopatadine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Tasimelteon.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Eplerenone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with methazolamide.", "severity": 2}
{"drug1": "Micafungin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with cinnarizine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with desoximetasone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with irbesartan.", "severity": 2}
{"drug1": "nicergoline", "drug2": "josamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with josamycin.", "severity": 2}
{"drug1": "Fludarabine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fludarabine is combined with leflunomide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with aspirin.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with donepezil.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with clemastine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Icatibant.", "severity": 2}
{"drug1": "codeine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with topiramate.", "severity": 2}
{"drug1": "clomipramine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with minoxidil.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Apremilast.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with acebutolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with enflurane.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with captopril.", "severity": 2}
{"drug1": "chloroxine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with bumetanide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with methocarbamol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with methylphenidate.", "severity": 2}
{"drug1": "spironolactone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with furosemide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with triprolidine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "salicylamide", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with homoharringtonine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "sulconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Propoxycaine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with nicardipine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Flibanserin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tizanidine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Pramocaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with furosemide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with DEZOCINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Eszopiclone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with baclofen.", "severity": 2}
{"drug1": "propranolol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with nisoldipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Levetiracetam.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Flibanserin.", "severity": 2}
{"drug1": "difluprednate", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with enoxacin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Remoxipride.", "severity": 2}
{"drug1": "butabarbital", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with loxapine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with oxazepam.", "severity": 2}
{"drug1": "amiodarone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Articaine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Almotriptan.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with amoxapine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with nortriptyline.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Pregabalin.", "severity": 2}
{"drug1": "Limaprost", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with cilostazol.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nilvadipine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Telmisartan.", "severity": 2}
{"drug1": "prazosin", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Eplerenone.", "severity": 2}
{"drug1": "reserpine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ketamine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Tasimelteon.", "severity": 2}
{"drug1": "prazosin", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with methazolamide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with chlorthalidone.", "severity": 2}
{"drug1": "ketamine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with fluvastatin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apixaban is combined with meperidine.", "severity": 2}
{"drug1": "propofol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with dyclonine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "midazolam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with baclofen.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Efonidipine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with ketoprofen.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with Rosuvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with metolazone.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with diphenhydramine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Olsalazine.", "severity": 2}
{"drug1": "codeine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with oxycodone.", "severity": 2}
{"drug1": "codeine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with buspirone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with trifluoperazine.", "severity": 2}
{"drug1": "quinapril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with sulfasalazine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with topiramate.", "severity": 2}
{"drug1": "triazolam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with carisoprodol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with dibucaine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with sulpiride.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Flibanserin.", "severity": 2}
{"drug1": "propranolol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with minoxidil.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with floctafenine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with proparacaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with pimozide.", "severity": 2}
{"drug1": "etodolac", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with topiramate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with zonisamide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with sulpiride.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Risedronic acid.", "severity": 2}
{"drug1": "reserpine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nitrazepam.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with tiagabine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Retigabine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with sertraline.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "benazepril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Nepafenac.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with decamethonium.", "severity": 2}
{"drug1": "bromazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with papaverine.", "severity": 2}
{"drug1": "buspirone", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with isoflurane.", "severity": 2}
{"drug1": "buspirone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ethotoin.", "severity": 2}
{"drug1": "metaraminol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with vigabatrin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with flunitrazepam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with benzocaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with cilnidipine.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Voriconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Voriconazole.", "severity": 2}
{"drug1": "methysergide", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Phenelzine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Aceclofenac.", "severity": 2}
{"drug1": "efavirenz", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with tiagabine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Methadyl acetate.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with estazolam.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Vilanterol.", "severity": 2}
{"drug1": "estazolam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with dibucaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Normethadone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with perphenazine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Torasemide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with procaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clomiphene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with zopiclone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Melatonin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with trimipramine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with oxymorphone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ramipril.", "severity": 2}
{"drug1": "diazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with clonazepam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Pizotifen.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with tiapride.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with nisoldipine.", "severity": 2}
{"drug1": "methadone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Halazepam.", "severity": 2}
{"drug1": "methadone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with proparacaine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with selegiline.", "severity": 2}
{"drug1": "methadone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with indapamide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with fludiazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with estazolam.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with tretinoin.", "severity": 2}
{"drug1": "selegiline", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with apraclonidine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when edrophonium is combined with nicotine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when edrophonium is combined with Cevimeline.", "severity": 2}
{"drug1": "mesalamine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with amisulpride.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Asenapine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Lormetazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with baclofen.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Melatonin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with irbesartan.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Flibanserin.", "severity": 2}
{"drug1": "diazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Torasemide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Ziprasidone.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with butalbital.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Milnacipran.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nitrendipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with VERAPAMIL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with flumethasone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Canagliflozin.", "severity": 2}
{"drug1": "methysergide", "drug2": "ceritinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ceritinib.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with metoclopramide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with scopolamine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Remoxipride.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with levodopa.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with cilazapril.", "severity": 2}
{"drug1": "indapamide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with papaverine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Fospropofol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "estrone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with rivastigmine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Pefloxacin.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with triamcinolone.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with scopolamine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with nitrous oxide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with clofazimine.", "severity": 2}
{"drug1": "indapamide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with nifedipine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "clozapine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with MOLINDONE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Cis-mdp.", "severity": 2}
{"drug1": "clozapine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Aceprometazine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with selegiline.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with MOLINDONE.", "severity": 2}
{"drug1": "indapamide", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with diazoxide.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with barnidipine.", "severity": 2}
{"drug1": "timolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "isradipine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with domperidone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Metixene.", "severity": 2}
{"drug1": "acebutolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with penbutolol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with brotizolam.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Levetiracetam.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with alclofenac.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Articaine.", "severity": 2}
{"drug1": "carboplatin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboplatin is combined with leflunomide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Clevidipine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with oxprenolol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with nitrazepam.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with quetiapine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with PAMABROM.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Difenoxin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with sulpiride.", "severity": 2}
{"drug1": "thiopental", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with fludiazepam.", "severity": 2}
{"drug1": "gabapentin", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with carisoprodol.", "severity": 2}
{"drug1": "thiopental", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with chloral hydrate.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Olmesartan.", "severity": 2}
{"drug1": "Torasemide", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with isradipine.", "severity": 2}
{"drug1": "meperidine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with halothane.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Trabectedin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Trabectedin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Retigabine.", "severity": 2}
{"drug1": "meperidine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with desipramine.", "severity": 2}
{"drug1": "triamterene", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with BISOPROLOL.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with imipramine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Pipotiazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with irbesartan.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with thiothixene.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Fluspirilene.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Atracurium besylate.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with thiamylal.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Conivaptan.", "severity": 2}
{"drug1": "thiothixene", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with flunarizine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with maprotiline.", "severity": 2}
{"drug1": "meclizine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with sertraline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with bromazepam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Fencamfamin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with rabeprazole.", "severity": 2}
{"drug1": "isoflurane", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with thioridazine.", "severity": 2}
{"drug1": "Articaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with amoxapine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with antipyrine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with apraclonidine.", "severity": 2}
{"drug1": "promethazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with quinapril.", "severity": 2}
{"drug1": "methysergide", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Regorafenib.", "severity": 2}
{"drug1": "secobarbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with carisoprodol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with carprofen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with labetalol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with thiopental.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with cilazapril.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ethosuximide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with doxazosin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with promazine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Arformoterol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "lisinopril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with carvedilol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with loratadine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with droperidol.", "severity": 2}
{"drug1": "epirizole", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with diflorasone.", "severity": 2}
{"drug1": "Articaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Tasimelteon.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Mephobarbital.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nitroglycerin.", "severity": 2}
{"drug1": "ibudilast", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with lisinopril.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Propoxycaine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when physostigmine is combined with methacholine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Pomalidomide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Desloratadine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with fluocinonide.", "severity": 2}
{"drug1": "imipramine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with meclizine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "selegiline", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with dichlorphenamide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with leflunomide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with prednisone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Clobetasone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with astemizole.", "severity": 2}
{"drug1": "cabergoline", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with rivastigmine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with levodopa.", "severity": 2}
{"drug1": "resveratrol", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with difluprednate.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxychloroquine is combined with mefloquine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with mesalamine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Butethal.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Pregabalin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Hexobarbital.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with lithium ion.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Pipamperone.", "severity": 2}
{"drug1": "bumetanide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with mecamylamine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Naftifine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Clevidipine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with citalopram.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Lorcaserin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with biperiden.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ramipril.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with tetracaine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with ESMOLOL.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Amrinone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with levodopa.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Canagliflozin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with amitriptyline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with valsartan.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with fluvoxamine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "floxuridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with floxuridine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with zaltoprofen.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with fludrocortisone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with levodopa.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nisoldipine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with METAXALONE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with fexofenadine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Canagliflozin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "tetracaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with methocarbamol.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Riociguat.", "severity": 2}
{"drug1": "zopiclone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with amoxapine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with diflunisal.", "severity": 2}
{"drug1": "quazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with cocaine.", "severity": 2}
{"drug1": "quazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with tiagabine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Risedronic acid.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Tasimelteon.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with prazosin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with DEZOCINE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Milnacipran.", "severity": 2}
{"drug1": "sulindac", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with acemetacin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with rivastigmine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with physostigmine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with clemastine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with promethazine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with methoxyflurane.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with Aliskiren.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with venlafaxine.", "severity": 2}
{"drug1": "isradipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with D-mannitol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with CLONIXIN.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with fleroxacin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with minoxidil.", "severity": 2}
{"drug1": "Naftifine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with desoximetasone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Retigabine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Vinflunine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Vinflunine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Loxoprofen.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Droxicam.", "severity": 2}
{"drug1": "tolmetin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Pipotiazine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with desipramine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with cyclothiazide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Tixocortol.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with fludrocortisone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with sulpiride.", "severity": 2}
{"drug1": "levodopa", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with selegiline.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Normethadone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with carisoprodol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Caspofungin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with methscopolamine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Lercanidipine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with ROSOXACIN.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with cilazapril.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Nebivolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with loxapine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Tasimelteon.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Naftifine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with AMILORIDE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with quinapril.", "severity": 2}
{"drug1": "nicardipine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with doxazosin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Propacetamol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with labetalol.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cobicistat is combined with Abemaciclib.", "severity": 2}
{"drug1": "terazosin", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with quetiapine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with pimozide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Gallium nitrate", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gallium nitrate is combined with leflunomide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with ethotoin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with metoprolol.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clenbuterol is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with fexofenadine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Pomalidomide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with naratriptan.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with rizatriptan.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with acetazolamide.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with sertraline.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clarithromycin is combined with toremifene.", "severity": 2}
{"drug1": "topiramate", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Clevidipine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with oxycodone.", "severity": 2}
{"drug1": "felodipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Bretylium.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with estrone.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with buprenorphine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Ramelteon.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with tetracaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Pipamperone.", "severity": 2}
{"drug1": "clidinium", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with clomipramine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with dobutamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with homoharringtonine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with Pregabalin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Etidocaine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with resveratrol.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with dantrolene.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Pizotifen.", "severity": 2}
{"drug1": "sulindac", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with flumethasone.", "severity": 2}
{"drug1": "loxapine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with MELPERONE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Difenoxin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with theobromine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "reserpine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with diltiazem.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with HYDROCODONE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Enalaprilat.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with potassium ion.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with budesonide.", "severity": 2}
{"drug1": "tiagabine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "meclizine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with clomipramine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Efonidipine.", "severity": 2}
{"drug1": "promazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with topiramate.", "severity": 2}
{"drug1": "pramipexole", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with terazosin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with medrysone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with fosinopril.", "severity": 2}
{"drug1": "papaverine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Clevidipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with propranolol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Riociguat.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with butamben.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with clonidine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with nisoldipine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with AMILORIDE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with periciazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with bromazepam.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with leflunomide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with MOLINDONE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with anastrozole.", "severity": 2}
{"drug1": "leflunomide", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with formestane.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Levalbuterol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Salmeterol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with polythiazide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with methazolamide.", "severity": 2}
{"drug1": "loratadine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with maprotiline.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with chlormezanone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Flibanserin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with clotiazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with clonazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Melatonin.", "severity": 2}
{"drug1": "thalidomide", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with fosinopril.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with vigabatrin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "reserpine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with butamben.", "severity": 2}
{"drug1": "lisinopril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with celecoxib.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with HEROIN.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Ropivacaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with bupivacaine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with betamethasone.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with butorphanol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Etomidate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Pomalidomide.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "procarbazine", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with bezafibrate.", "severity": 2}
{"drug1": "methadone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Levocetirizine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with prochlorperazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyamphetamine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Articaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with meclizine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Metipranolol.", "severity": 2}
{"drug1": "Spirapril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with brotizolam.", "severity": 2}
{"drug1": "halothane", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with cilazapril.", "severity": 2}
{"drug1": "medrysone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with donepezil.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Articaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Desloratadine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with codeine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Indacaterol.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with penbutolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Riociguat.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Dapagliflozin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Nebivolol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with amisulpride.", "severity": 2}
{"drug1": "moclobemide", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with MELPERONE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with scopolamine.", "severity": 2}
{"drug1": "carprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with nefazodone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with zotepine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Levetiracetam.", "severity": 2}
{"drug1": "naratriptan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "terconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with isradipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Flibanserin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "chloroquine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with flurandrenolide.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with salicylamide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with pravastatin.", "severity": 2}
{"drug1": "methysergide", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Enasidenib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Flibanserin.", "severity": 2}
{"drug1": "quinidine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Mirabegron.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Agomelatine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with halcinonide.", "severity": 2}
{"drug1": "risperidone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Normethadone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Perospirone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with alclofenac.", "severity": 2}
{"drug1": "risperidone", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with triazolam.", "severity": 2}
{"drug1": "triprolidine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Linagliptin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "pramipexole", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with tolazoline.", "severity": 2}
{"drug1": "naratriptan", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with rizatriptan.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with desoximetasone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with levorphanol.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Fosphenytoin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Apremilast.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with diflorasone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with lovastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with maprotiline.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Flibanserin.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with azelastine.", "severity": 2}
{"drug1": "methysergide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with risperidone.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with oxycodone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with METAXALONE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with meperidine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with amisulpride.", "severity": 2}
{"drug1": "protriptyline", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with imipramine.", "severity": 2}
{"drug1": "isoniazid", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoniazid is combined with atorvastatin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with hydralazine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ethanol", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with moclobemide.", "severity": 2}
{"drug1": "ethanol", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Escitalopram.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with flurbiprofen.", "severity": 2}
{"drug1": "etizolam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with brotizolam.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with acemetacin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with metolazone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with halothane.", "severity": 2}
{"drug1": "labetalol", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with phenmetrazine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with topiramate.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with desipramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Aceprometazine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with thiamylal.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with fexofenadine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "miconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with barnidipine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Halobetasol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with fludiazepam.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Vecuronium.", "severity": 2}
{"drug1": "tolterodine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with pancuronium.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with GUANFACINE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with METAXALONE.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Pizotifen.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Eprosartan.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Nepafenac.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with brotizolam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with triflupromazine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with alclometasone.", "severity": 2}
{"drug1": "carprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with estrone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nitrendipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with fenbufen.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Pizotifen.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Difenoxin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with GUANFACINE.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with enoxacin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with indapamide.", "severity": 2}
{"drug1": "triazolam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Mephobarbital.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Etidronic acid.", "severity": 2}
{"drug1": "Icatibant", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with triamcinolone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Remoxipride.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with vigabatrin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with hydralazine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with estrone.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with ropinirole.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with ethosuximide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Estrone sulfate.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with butamben.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Cis-mdp.", "severity": 2}
{"drug1": "Etomidate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with paroxetine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with ethotoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with prilocaine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with tranylcypromine.", "severity": 2}
{"drug1": "meclizine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with fluoxetine.", "severity": 2}
{"drug1": "meclizine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with duloxetine.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "didanosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with didanosine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with clonidine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with amisulpride.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with propranolol.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Flupentixol.", "severity": 2}
{"drug1": "meperidine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with clidinium.", "severity": 2}
{"drug1": "meperidine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Aripiprazole.", "severity": 2}
{"drug1": "Butethal", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with clomiphene.", "severity": 2}
{"drug1": "prednisone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with formoterol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with mesoridazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with sulfasalazine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with propoxyphene.", "severity": 2}
{"drug1": "pentazocine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with clemastine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with lidocaine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with fluocinonide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Salsalate.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Clevidipine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with meperidine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Tolcapone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with doxepin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Clodronic Acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Oxetacaine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with diflunisal.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "brotizolam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with sertraline.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with anastrozole.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Remoxipride.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with methoxyflurane.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with tizanidine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Etomidate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with diflorasone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Ropivacaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with bupivacaine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with zonisamide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with aspirin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with propranolol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with clonidine.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with nefazodone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with bupivacaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Ropivacaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Etomidate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Pipamperone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with nalidixic acid.", "severity": 2}
{"drug1": "oxycodone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with bromazepam.", "severity": 2}
{"drug1": "triamterene", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Aliskiren.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Masoprocol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with malathion.", "severity": 2}
{"drug1": "temazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with thiamylal.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with sertraline.", "severity": 2}
{"drug1": "levorphanol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "temazepam", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with prochlorperazine.", "severity": 2}
{"drug1": "ramipril", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with BISOPROLOL.", "severity": 2}
{"drug1": "valsartan", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with chlorthalidone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Tramadol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with triazolam.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with HEROIN.", "severity": 2}
{"drug1": "butabarbital", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with MOLINDONE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with biperiden.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with chlorprothixene.", "severity": 2}
{"drug1": "codeine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with clonazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with promethazine.", "severity": 2}
{"drug1": "doxepin", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with clomipramine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "sulconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with gabapentin.", "severity": 2}
{"drug1": "doxepin", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with isocarboxazid.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Naloxegol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Levobupivacaine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Levalbuterol.", "severity": 2}
{"drug1": "propofol", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Milnacipran.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with nimesulide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with carisoprodol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with sulpiride.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nimodipine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "halothane", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with MOXONIDINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with D-mannitol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with sulfasalazine.", "severity": 2}
{"drug1": "Trospium", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Propiverine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with propofol.", "severity": 2}
{"drug1": "midazolam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with lithium ion.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with papaverine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Telmisartan.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with droperidol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with nifedipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with thiothixene.", "severity": 2}
{"drug1": "tizanidine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with promethazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Pipotiazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with tizanidine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with butamben.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Phenelzine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with timolol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Iloperidone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with buspirone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ximelagatran is combined with Temsirolimus.", "severity": 2}
{"drug1": "loxapine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with dantrolene.", "severity": 2}
{"drug1": "Salsalate", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Salsalate", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with paramethasone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with mesalamine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with fluocinonide.", "severity": 2}
{"drug1": "sulfathiazole", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfathiazole is combined with mecamylamine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Desloratadine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Etidocaine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with Escitalopram.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with flumethasone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with mesalamine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with levorphanol.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with pravastatin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with formestane.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with tizanidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with trifluoperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with doxepin.", "severity": 2}
{"drug1": "quazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with lithium ion.", "severity": 2}
{"drug1": "quazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with efavirenz.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Butethal.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "midazolam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Etidocaine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with citalopram.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with nitroglycerin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with lisinopril.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with spironolactone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with propranolol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with clonidine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Olopatadine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with fluvastatin.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with barnidipine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Aliskiren.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with Rosuvastatin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with trazodone.", "severity": 2}
{"drug1": "nystatin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with diltiazem.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with naratriptan.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with rizatriptan.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with METAXALONE.", "severity": 2}
{"drug1": "quinapril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with antipyrine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with methyldopa.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with simvastatin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with apraclonidine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Telmisartan.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Articaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "halcinonide", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with ROSOXACIN.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Eplerenone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with methazolamide.", "severity": 2}
{"drug1": "terbinafine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with felodipine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with papaverine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with nifedipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with SUFENTANIL.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Olopatadine.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with ethchlorvynol.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Pipotiazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Eprosartan.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Empagliflozin.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with epoprostenol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with baclofen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with cocaine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with dexamethasone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with mefenamic acid.", "severity": 2}
{"drug1": "terbinafine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with gabapentin.", "severity": 2}
{"drug1": "triazolam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with imipramine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "triazolam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with loratadine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with NAPROXEN.", "severity": 2}
{"drug1": "decamethonium", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when decamethonium is combined with pilocarpine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Oxetacaine.", "severity": 2}
{"drug1": "morphine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nitrous oxide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with reserpine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with carisoprodol.", "severity": 2}
{"drug1": "retinol", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when retinol is combined with ADAPALENE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "temazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Etidronic acid.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with GUANFACINE.", "severity": 2}
{"drug1": "felbamate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with theobromine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "captopril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with ZILEUTON.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "propranolol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with captopril.", "severity": 2}
{"drug1": "cerulenin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with isradipine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with triamterene.", "severity": 2}
{"drug1": "captopril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with etodolac.", "severity": 2}
{"drug1": "halothane", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with prazepam.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with diltiazem.", "severity": 2}
{"drug1": "nicergoline", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with efavirenz.", "severity": 2}
{"drug1": "nicergoline", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with testosterone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Perospirone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with Demecarium.", "severity": 2}
{"drug1": "quazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with mesoridazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "butenafine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with nilvadipine.", "severity": 2}
{"drug1": "retinol", "drug2": "Isotretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when retinol is combined with Isotretinoin.", "severity": 2}
{"drug1": "diazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with sulpiride.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Lornoxicam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with proparacaine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with fluocinonide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with D-mannitol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with domperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with meperidine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Etoricoxib.", "severity": 2}
{"drug1": "reserpine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with prazosin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Empagliflozin.", "severity": 2}
{"drug1": "sulconazole", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with pravastatin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Paliperidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with carisoprodol.", "severity": 2}
{"drug1": "reserpine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with mesoridazine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with sulpiride.", "severity": 2}
{"drug1": "dyclonine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with cetirizine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with lidocaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Etoricoxib.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with ambenonium.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with D-mannitol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with ROSOXACIN.", "severity": 2}
{"drug1": "halothane", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nitrendipine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Halazepam.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with flunisolide.", "severity": 2}
{"drug1": "etodolac", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Apremilast.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with proparacaine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with moclobemide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Etoricoxib.", "severity": 2}
{"drug1": "cocaine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with oxprenolol.", "severity": 2}
{"drug1": "cocaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Olsalazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Thioproperazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with thiothixene.", "severity": 2}
{"drug1": "cocaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with prazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "epirizole", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with homoharringtonine.", "severity": 2}
{"drug1": "timolol", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with metolazone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with bezafibrate.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "dyclonine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with cocaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with vigabatrin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with benzocaine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Levetiracetam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Paliperidone.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Vorapaxar", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Vorapaxar.", "severity": 2}
{"drug1": "barnidipine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "barnidipine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with tolazoline.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Efonidipine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with salicylic acid.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with meclofenamic acid.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with alclometasone.", "severity": 2}
{"drug1": "temazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Clevidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with atenolol.", "severity": 2}
{"drug1": "morphine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with olanzapine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with nefazodone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Mersalyl.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with doxepin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with hydromorphone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with methyclothiazide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "gabapentin", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with levodopa.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with isradipine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Aripiprazole.", "severity": 2}
{"drug1": "Tramadol", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with pimozide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Olmesartan.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Fencamfamin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Retigabine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Pipamperone.", "severity": 2}
{"drug1": "isradipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with acebutolol.", "severity": 2}
{"drug1": "meperidine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "diflunisal", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with loteprednol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with baclofen.", "severity": 2}
{"drug1": "topiramate", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with maprotiline.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with niflumic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Ethylmorphine.", "severity": 2}
{"drug1": "amifostine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with halothane.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Fencamfamin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Melatonin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with nilvadipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Fosaprepitant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Fosaprepitant.", "severity": 2}
{"drug1": "prazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with tizanidine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "levorphanol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with promethazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with clonazepam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Fencamfamin.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with amitriptyline.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Tolcapone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with acetylcholine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with prazepam.", "severity": 2}
{"drug1": "losartan", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with alclofenac.", "severity": 2}
{"drug1": "morphine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with labetalol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with nifedipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with papaverine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Nebivolol.", "severity": 2}
{"drug1": "morphine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with doxazosin.", "severity": 2}
{"drug1": "morphine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ethosuximide.", "severity": 2}
{"drug1": "morphine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with AMILORIDE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Nebivolol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with ibuprofen.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Retigabine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with ethosuximide.", "severity": 2}
{"drug1": "carprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with Pefloxacin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with fluoxetine.", "severity": 2}
{"drug1": "prazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with cetirizine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "prazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with protriptyline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "bleomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with bleomycin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "chlorambucil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with chlorambucil.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Flupentixol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Lorcaserin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with GUANFACINE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with pirenzepine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with ethotoin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with oxazepam.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with doxorubicin.", "severity": 2}
{"drug1": "tiapride", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Difenoxin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Pregabalin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with DESFLURANE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextroamphetamine is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with methazolamide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with galanthamine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Eplerenone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with alprazolam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Agomelatine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with nisoldipine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with SUFENTANIL.", "severity": 2}
{"drug1": "temozolomide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temozolomide is combined with clozapine.", "severity": 2}
{"drug1": "carboprost trometamol", "drug2": "dinoprost tromethamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboprost trometamol is combined with dinoprost tromethamine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Empagliflozin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with flunisolide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with hydrocortisone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with efavirenz.", "severity": 2}
{"drug1": "thiopental", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with clonazepam.", "severity": 2}
{"drug1": "thiopental", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Melatonin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Oxetacaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Normethadone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with METAXALONE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with methyldopa.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with apraclonidine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Telmisartan.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with methazolamide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with amoxapine.", "severity": 2}
{"drug1": "retinol", "drug2": "Acitretin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when retinol is combined with Acitretin.", "severity": 2}
{"drug1": "quazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with desipramine.", "severity": 2}
{"drug1": "quazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with thiamylal.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "furosemide", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with IDARUBICIN.", "severity": 2}
{"drug1": "methadone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with triamterene.", "severity": 2}
{"drug1": "furosemide", "drug2": "kanamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with kanamycin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with clomipramine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Escitalopram.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with loteprednol.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with clonidine.", "severity": 2}
{"drug1": "pimozide", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with enflurane.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with propranolol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with flumethasone.", "severity": 2}
{"drug1": "furosemide", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with indapamide.", "severity": 2}
{"drug1": "carprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with alclofenac.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with duloxetine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lovastatin is combined with Flibanserin.", "severity": 2}
{"drug1": "methadone", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with pentazocine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Etidronic acid.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Melatonin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with dextromethorphan.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with clonazepam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with promethazine.", "severity": 2}
{"drug1": "promazine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with oxazepam.", "severity": 2}
{"drug1": "promazine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with nalbuphine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with methylprednisolone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Aceprometazine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Retigabine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with amobarbital.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with nalbuphine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with doxepin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Pipamperone.", "severity": 2}
{"drug1": "promazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "albendazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with albendazole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "estramustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with estramustine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "promazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with thiopental.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Etomidate.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Pizotifen.", "severity": 2}
{"drug1": "promazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with ethosuximide.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with PENTAERYTHRITOL TETRANITRATE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with fexofenadine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Olopatadine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with tiagabine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with butorphanol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with zonisamide.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with scopolamine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with efavirenz.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with clomipramine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with vinblastine.", "severity": 2}
{"drug1": "quinidine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with dapsone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with Demecarium.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with ethotoin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with amisulpride.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "SAQUINAVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rifampicin is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with prilocaine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with resveratrol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with tranylcypromine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with ROSOXACIN.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with ondansetron.", "severity": 2}
{"drug1": "methysergide", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with lidocaine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Riociguat.", "severity": 2}
{"drug1": "enalapril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Apremilast.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Remoxipride.", "severity": 2}
{"drug1": "procarbazine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with loxapine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with chlorzoxazone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with levodopa.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with levodopa.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with fluocinonide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "cyclosporin A", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with cyclosporin A.", "severity": 2}
{"drug1": "methysergide", "drug2": "nevirapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nevirapine.", "severity": 2}
{"drug1": "methadone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Fospropofol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Cariprazine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with oxyphenonium.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with vigabatrin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with potassium ion.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyzine is combined with venlafaxine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with trazodone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with DESONIDE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Flibanserin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with meclizine.", "severity": 2}
{"drug1": "primidone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "isradipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with acebutolol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Ciclesonide.", "severity": 2}
{"drug1": "Benidipine", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with lovastatin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with flunitrazepam.", "severity": 2}
{"drug1": "etodolac", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with dexamethasone.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with sparfloxacin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with doxepin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with atenolol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Telmisartan.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Fospropofol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with efavirenz.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Bretylium.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with gabapentin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with meclizine.", "severity": 2}
{"drug1": "morphine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ketamine.", "severity": 2}
{"drug1": "valsartan", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ramipril.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Risedronic acid.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with nimesulide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Fospropofol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with betaxolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Ketobemidone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with haloperidol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with thiamylal.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Tixocortol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with labetalol.", "severity": 2}
{"drug1": "loxapine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with bromazepam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with scopolamine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with metoclopramide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with halothane.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "loxapine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with METAXALONE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with VERAPAMIL.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with deslanoside.", "severity": 2}
{"drug1": "sulindac", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with GUANFACINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "propantheline", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Sacubitril.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Frovatriptan.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with paramethasone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with butalbital.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "anagrelide", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with diflunisal.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "phenindione", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with phenindione.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with triamterene.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with lidocaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Potassium citrate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with halothane.", "severity": 2}
{"drug1": "pergolide", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with oxymetholone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Escitalopram.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with thiamylal.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with hyoscyamine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with methadone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ESMOLOL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with baclofen.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with olanzapine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Oxetacaine.", "severity": 2}
{"drug1": "losartan", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with benazepril.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Desloratadine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with mecamylamine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with norfloxacin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Levetiracetam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nitrendipine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with maprotiline.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with imipramine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with nitrous oxide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with tiapride.", "severity": 2}
{"drug1": "prilocaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with loratadine.", "severity": 2}
{"drug1": "aspirin", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with proparacaine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with fenoldopam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Halazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with butorphanol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with hydromorphone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with indapamide.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Olopatadine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Fosphenytoin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with baclofen.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "tetracaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with clonazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with felbamate.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "formestane", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Demecarium.", "severity": 2}
{"drug1": "loxapine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with midazolam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with thiothixene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with prazepam.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bevantolol is combined with Varenicline.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with gabapentin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with oxprenolol.", "severity": 2}
{"drug1": "prednisone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "amiodarone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with nitroglycerin.", "severity": 2}
{"drug1": "propofol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Propacetamol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Oxetacaine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Ciclesonide.", "severity": 2}
{"drug1": "amisulpride", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with meclizine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Perospirone.", "severity": 2}
{"drug1": "propantheline", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Atracurium besylate.", "severity": 2}
{"drug1": "fosinopril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with epirizole.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "trimetrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with trimetrexate.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with flunarizine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Loxoprofen.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Droxicam.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Etidocaine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with CLONIXIN.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Alvimopan.", "severity": 2}
{"drug1": "dyclonine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with paroxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with amisulpride.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with prazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with citalopram.", "severity": 2}
{"drug1": "imipramine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with chlorothiazide.", "severity": 2}
{"drug1": "imipramine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with fluvoxamine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with flunisolide.", "severity": 2}
{"drug1": "medrysone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with norfloxacin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "isoniazid", "drug2": "D-cycloserine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoniazid is combined with D-cycloserine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with Eplerenone.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with hyoscyamine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Propiverine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with venlafaxine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with ambenonium.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with Tapentadol.", "severity": 2}
{"drug1": "methadone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Flibanserin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Pipamperone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with scopolamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Levalbuterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "metolazone", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Eprosartan.", "severity": 2}
{"drug1": "Demecarium", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Demecarium is combined with pilocarpine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with mycophenolic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with DESONIDE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with cyclothiazide.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with methylphenidate.", "severity": 2}
{"drug1": "timolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with periciazine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with tiapride.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with benazepril.", "severity": 2}
{"drug1": "triazolam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Etomidate.", "severity": 2}
{"drug1": "codeine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Articaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Ropivacaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with bupivacaine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Carbocisteine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with brotizolam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with thiothixene.", "severity": 2}
{"drug1": "quinapril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Temsirolimus.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with tolmetin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amodiaquine is combined with dapsone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with cocaine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with malathion.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Fencamfamin.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with felbamate.", "severity": 2}
{"drug1": "estazolam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with meclizine.", "severity": 2}
{"drug1": "doxepin", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with dantrolene.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Fencamfamin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Retigabine.", "severity": 2}
{"drug1": "benazepril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with papaverine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Melatonin.", "severity": 2}
{"drug1": "methysergide", "drug2": "Cobicistat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Cobicistat.", "severity": 2}
{"drug1": "nimesulide", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with flurandrenolide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with enalapril.", "severity": 2}
{"drug1": "butalbital", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with clonazepam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with clonidine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with zotepine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with MELPERONE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with atorvastatin.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Benidipine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "tolterodine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with oxycodone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with bromazepam.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with cilnidipine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with desoximetasone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Nabilone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with brimonidine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Icatibant.", "severity": 2}
{"drug1": "halothane", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "metaraminol", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with thiopental.", "severity": 2}
{"drug1": "halothane", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Metipranolol.", "severity": 2}
{"drug1": "halothane", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with dantrolene.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with ethosuximide.", "severity": 2}
{"drug1": "Normethadone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with felbamate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Etidocaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with glutethimide.", "severity": 2}
{"drug1": "bepridil", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with metoprolol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with benzocaine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with vigabatrin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with dihydroergotamine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with formestane.", "severity": 2}
{"drug1": "benazepril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with hydralazine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Lorcaserin.", "severity": 2}
{"drug1": "sulconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naloxegol is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with zotepine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with MELPERONE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Empagliflozin.", "severity": 2}
{"drug1": "sotalol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with nicardipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with desipramine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with methyclothiazide.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with promethazine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Fospropofol.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with Aliskiren.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with trandolapril.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with methoxyflurane.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Salbutamol.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with NAPROXEN.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with mefenamic acid.", "severity": 2}
{"drug1": "estazolam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Mephobarbital.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Agomelatine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Levocetirizine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with triamterene.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with amisulpride.", "severity": 2}
{"drug1": "quinapril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "sotalol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with AMILORIDE.", "severity": 2}
{"drug1": "azelastine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with formestane.", "severity": 2}
{"drug1": "valsartan", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with methyclothiazide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with methazolamide.", "severity": 2}
{"drug1": "meperidine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with nitric oxide.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Flibanserin.", "severity": 2}
{"drug1": "meperidine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with METAXALONE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with protriptyline.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with amoxapine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with niflumic acid.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with procaine.", "severity": 2}
{"drug1": "meperidine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with prazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with trifluoperazine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sildenafil is combined with atorvastatin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Fesoterodine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with trazodone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with cilazapril.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with dyclonine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with propoxyphene.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with SUFENTANIL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Difenoxin.", "severity": 2}
{"drug1": "baclofen", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Olopatadine.", "severity": 2}
{"drug1": "valsartan", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Ramelteon.", "severity": 2}
{"drug1": "moclobemide", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with mianserin.", "severity": 2}
{"drug1": "meperidine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with trazodone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with mecamylamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with triamterene.", "severity": 2}
{"drug1": "butalbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Tolcapone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Agomelatine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Ketobemidone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Frovatriptan.", "severity": 2}
{"drug1": "Tramadol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with methoxyflurane.", "severity": 2}
{"drug1": "benazepril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with chloroquine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with hydrocortisone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with carvedilol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with trichlormethiazide.", "severity": 2}
{"drug1": "benazepril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with sulindac.", "severity": 2}
{"drug1": "indomethacin", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with celecoxib.", "severity": 2}
{"drug1": "clozapine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Vorapaxar", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Vorapaxar.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with halothane.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Eprosartan.", "severity": 2}
{"drug1": "clozapine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with chlormezanone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with loratadine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Pomalidomide.", "severity": 2}
{"drug1": "enflurane", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with brotizolam.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Fospropofol.", "severity": 2}
{"drug1": "haloprogin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with nisoldipine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with diclofenac.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Potassium citrate.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with enalapril.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Lofexidine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with isoxsuprine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with paroxetine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "kanamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with kanamycin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with IDARUBICIN.", "severity": 2}
{"drug1": "oxycodone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "letrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with letrozole.", "severity": 2}
{"drug1": "pentazocine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with D-mannitol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "hydroxyurea", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with hydroxyurea.", "severity": 2}
{"drug1": "pentazocine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with scopolamine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Fluspirilene.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with norfloxacin.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with vigabatrin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "busulfan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with busulfan.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Flupentixol.", "severity": 2}
{"drug1": "flunisolide", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with fleroxacin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with GUANFACINE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with imipramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with thiamylal.", "severity": 2}
{"drug1": "etodolac", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with azelastine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Tasimelteon.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with difluprednate.", "severity": 2}
{"drug1": "Icatibant", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with halcinonide.", "severity": 2}
{"drug1": "doxepin", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with procarbazine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with streptozocin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Levalbuterol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with salicylic acid.", "severity": 2}
{"drug1": "morphine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ramipril.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with zaltoprofen.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with clomipramine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with baclofen.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with fexofenadine.", "severity": 2}
{"drug1": "enflurane", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with rescinnamine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with brotizolam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Metipranolol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Eprosartan.", "severity": 2}
{"drug1": "azelastine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with resveratrol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with chloral hydrate.", "severity": 2}
{"drug1": "suprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "suprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "quazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with clidinium.", "severity": 2}
{"drug1": "codeine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with dantrolene.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with timolol.", "severity": 2}
{"drug1": "pimozide", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with methocarbamol.", "severity": 2}
{"drug1": "pimozide", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with methylphenidate.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "pimozide", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with triprolidine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with amoxapine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with nortriptyline.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with imipramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with trazodone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with loratadine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Coenzyme Q10 is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "Articaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Milnacipran.", "severity": 2}
{"drug1": "bifonazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with nifedipine.", "severity": 2}
{"drug1": "promazine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Mephobarbital.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "suramin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with suramin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Flibanserin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with cilazapril.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "gabapentin", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with clonidine.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clarithromycin is combined with Temsirolimus.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with prazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with flunitrazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with meclizine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "lisinopril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with terazosin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Lormetazepam.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with KETAZOLAM.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with niflumic acid.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Iloperidone.", "severity": 2}
{"drug1": "selegiline", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Fencamfamin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Retigabine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Empagliflozin.", "severity": 2}
{"drug1": "methadone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with nortriptyline.", "severity": 2}
{"drug1": "estazolam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Retigabine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Articaine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Bretylium.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Ramelteon.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ibuprofen.", "severity": 2}
{"drug1": "Triflusal", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with aspirin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with promethazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with tioconazole.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with prazosin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with loratadine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with potassium ion.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with venlafaxine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with halothane.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with clemastine.", "severity": 2}
{"drug1": "diazepam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "butenafine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with nimodipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with methazolamide.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with droperidol.", "severity": 2}
{"drug1": "Perospirone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with clomipramine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with tolterodine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with lovastatin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Difenoxin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Metixene.", "severity": 2}
{"drug1": "thiopental", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with ethosuximide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with paramethasone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with tiagabine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Pimecrolimus.", "severity": 2}
{"drug1": "midodrine", "drug2": "methoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with methoxamine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with azelastine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Articaine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with indapamide.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Fosphenytoin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with alclometasone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Tixocortol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Empagliflozin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with trimipramine.", "severity": 2}
{"drug1": "captopril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Etoricoxib.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Ciclesonide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with buspirone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with oxycodone.", "severity": 2}
{"drug1": "pimozide", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with ketamine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with lithium ion.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with carvedilol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with scopolamine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with felodipine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Tramadol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Temsirolimus.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with paramethasone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "quinapril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "pimozide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "morphine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nilvadipine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with maprotiline.", "severity": 2}
{"drug1": "morphine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Fospropofol.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Aceclofenac.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with zaltoprofen.", "severity": 2}
{"drug1": "ibudilast", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with aspirin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with cinoxacin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with nitroglycerin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with SERATRODAST.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with thiothixene.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Pipotiazine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with carisoprodol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with sulpiride.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with flunitrazepam.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "duloxetine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with procarbazine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with fludrocortisone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Caspofungin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with fosinopril.", "severity": 2}
{"drug1": "oxazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with tiapride.", "severity": 2}
{"drug1": "Articaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with nortriptyline.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Nebivolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with clonidine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Tapentadol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with chlorprothixene.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with cilazapril.", "severity": 2}
{"drug1": "linezolid", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Almotriptan.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with diflunisal.", "severity": 2}
{"drug1": "buspirone", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with nalbuphine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nitrendipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "biperiden", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with hydromorphone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with sevoflurane.", "severity": 2}
{"drug1": "amiodarone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Trospium", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Butylscopolamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ropinirole.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with betamethasone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "morphine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with amoxapine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Remoxipride.", "severity": 2}
{"drug1": "oxazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with HEROIN.", "severity": 2}
{"drug1": "thioridazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with vigabatrin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Fospropofol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with NICORANDIL.", "severity": 2}
{"drug1": "suprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Metixene.", "severity": 2}
{"drug1": "itraconazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with oxycodone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Agomelatine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with timolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with doxepin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with enoxacin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with diazepam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with topiramate.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "halothane", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with butamben.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with pyridostigmine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with acemetacin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with tiagabine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Carbamylcholine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Pirlindole.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Toloxatone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Nebivolol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with difluprednate.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with sulindac.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Fluprednidene.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "sertraline", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with thiothixene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Oxetacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with chloral hydrate.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Mephobarbital.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Telmisartan.", "severity": 2}
{"drug1": "thiothixene", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with fludiazepam.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with nadolol.", "severity": 2}
{"drug1": "primidone", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with phenobarbital.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with benzyl alcohol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with nylidrin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with clonidine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "procyclidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with procyclidine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Pirlindole.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Toloxatone.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tamoxifen is combined with Ospemifene.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with atenolol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with tetracaine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with brotizolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with thioridazine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with betamethasone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with bumetanide.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with penbutolol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with doxepin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with nefazodone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with methyclothiazide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with cocaine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with doxepin.", "severity": 2}
{"drug1": "thiopental", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with topiramate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with zonisamide.", "severity": 2}
{"drug1": "reserpine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Pizotifen.", "severity": 2}
{"drug1": "docetaxel", "drug2": "tibolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with tibolone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Droxicam.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Ketobemidone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Quinupristin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with nefazodone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Propacetamol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Teriflunomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with penbutolol.", "severity": 2}
{"drug1": "methysergide", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with acetazolamide.", "severity": 2}
{"drug1": "methysergide", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with propofol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with quetiapine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with hydralazine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "cocaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with butamben.", "severity": 2}
{"drug1": "ceritinib", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ceritinib is combined with oxycodone.", "severity": 2}
{"drug1": "Stepronin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Stepronin is combined with leflunomide.", "severity": 2}
{"drug1": "codeine", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Toloxatone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with nortriptyline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with amoxapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with chlorprothixene.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Aliskiren.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Perospirone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with isocarboxazid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Droxicam", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with equilin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Aceprometazine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Fesoterodine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with MOLINDONE.", "severity": 2}
{"drug1": "quazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Pomalidomide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Raltitrexed", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Raltitrexed.", "severity": 2}
{"drug1": "protriptyline", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with doxepin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "chlorambucil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with chlorambucil.", "severity": 2}
{"drug1": "docetaxel", "drug2": "bleomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with bleomycin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with brotizolam.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Ropivacaine.", "severity": 2}
{"drug1": "nystatin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Olsalazine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with dopamine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ibuprofen.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Fencamfamin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "butamben", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Fosphenytoin.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with chloral hydrate.", "severity": 2}
{"drug1": "pramipexole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with diltiazem.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with fludiazepam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with moclobemide.", "severity": 2}
{"drug1": "carprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "oxycodone", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with risperidone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "methoxamine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with acebutolol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with chlormezanone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "carprofen", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with amcinonide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with donepezil.", "severity": 2}
{"drug1": "imipramine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with minoxidil.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with clotiazepam.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with chlorothiazide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with bumetanide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with isocarboxazid.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with propranolol.", "severity": 2}
{"drug1": "Apremilast", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with CLONIXIN.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with clonidine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with promethazine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with nisoldipine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with thiopental.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Trovafloxacin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Levocetirizine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Tixocortol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "reserpine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "dibucaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with clomipramine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with paroxetine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Trifluridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Trifluridine.", "severity": 2}
{"drug1": "amifostine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Tapentadol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Milnacipran.", "severity": 2}
{"drug1": "nimesulide", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with formestane.", "severity": 2}
{"drug1": "anastrozole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anastrozole is combined with atorvastatin.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with tolazoline.", "severity": 2}
{"drug1": "aspirin", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with methazolamide.", "severity": 2}
{"drug1": "imipramine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with METAXALONE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with tolfenamic acid.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with ouabain.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Panobinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Panobinostat.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with enoxacin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with amisulpride.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "loxapine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with doxepin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Levocetirizine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with papaverine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with acetylcholine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with enflurane.", "severity": 2}
{"drug1": "acemetacin", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with desoximetasone.", "severity": 2}
{"drug1": "meperidine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Perospirone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with chloroquine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with resveratrol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with paramethasone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with thiopental.", "severity": 2}
{"drug1": "azelastine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Etoricoxib.", "severity": 2}
{"drug1": "difluprednate", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with reserpine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Canagliflozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with sulindac.", "severity": 2}
{"drug1": "imipramine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Salbutamol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with trifluoperazine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with nifedipine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with fenbufen.", "severity": 2}
{"drug1": "protriptyline", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with trimipramine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nitroglycerin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with resveratrol.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Ketobemidone.", "severity": 2}
{"drug1": "halothane", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Pizotifen.", "severity": 2}
{"drug1": "prazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Retigabine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Metipranolol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with mesoridazine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with maprotiline.", "severity": 2}
{"drug1": "resveratrol", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with flumethasone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with clomipramine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Romidepsin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Romidepsin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with isradipine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Lormetazepam.", "severity": 2}
{"drug1": "valsartan", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with cinnarizine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "buspirone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with methoxyflurane.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with irbesartan.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with mefenamic acid.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Pipotiazine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with bumetanide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with quinapril.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with ritodrine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with felodipine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with mefloquine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with zotepine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinorelbine is combined with atorvastatin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Rotigotine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "amprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with amprenavir.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Eplerenone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with methazolamide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ADAPALENE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Cis-mdp.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "isradipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with decamethonium.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Olmesartan.", "severity": 2}
{"drug1": "zotepine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Riociguat.", "severity": 2}
{"drug1": "altretamine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when altretamine is combined with leflunomide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with papaverine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with procaine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with chlorprothixene.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Lurasidone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with sulpiride.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with timolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with acetazolamide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with carisoprodol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Eprosartan.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Deferasirox.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Clevidipine.", "severity": 2}
{"drug1": "sulindac", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with budesonide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Normethadone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Olopatadine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with flunarizine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with medrysone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Flibanserin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Desloratadine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with hydromorphone.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Flibanserin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with clenbuterol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with propoxyphene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with dyclonine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with paroxetine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "azelastine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Droxicam", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with hydrocortisone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with edrophonium.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Tixocortol.", "severity": 2}
{"drug1": "azelastine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with amcinonide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Hexobarbital.", "severity": 2}
{"drug1": "enalapril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Temsirolimus.", "severity": 2}
{"drug1": "milrinone", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with salicylic acid.", "severity": 2}
{"drug1": "perphenazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with tetracaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with propofol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Aliskiren.", "severity": 2}
{"drug1": "baclofen", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Flibanserin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Fluspirilene.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with flunarizine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with topiramate.", "severity": 2}
{"drug1": "zaleplon", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with chlorpheniramine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with cetirizine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with maprotiline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with selegiline.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Perospirone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with papaverine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with furosemide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nifedipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with tetracaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with MELPERONE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with zotepine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Levalbuterol.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Olopatadine.", "severity": 2}
{"drug1": "sulindac", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with sulfasalazine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with tiagabine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with efavirenz.", "severity": 2}
{"drug1": "triprolidine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with trimipramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "metolazone", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Pipamperone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with niflumic acid.", "severity": 2}
{"drug1": "loxapine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with topiramate.", "severity": 2}
{"drug1": "butalbital", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Pipotiazine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with chloral hydrate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with fludiazepam.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with toremifene.", "severity": 2}
{"drug1": "halothane", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with sulpiride.", "severity": 2}
{"drug1": "butorphanol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with furosemide.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "triazolam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with dyclonine.", "severity": 2}
{"drug1": "triazolam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with propoxyphene.", "severity": 2}
{"drug1": "moclobemide", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with dipivefrin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Clevidipine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with felbamate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Linagliptin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with methylprednisolone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Frovatriptan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with carisoprodol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with sulpiride.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nimodipine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Olopatadine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with amitriptyline.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Demecarium.", "severity": 2}
{"drug1": "butalbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Retigabine.", "severity": 2}
{"drug1": "ketamine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Pefloxacin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "quinapril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with flurbiprofen.", "severity": 2}
{"drug1": "lidocaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with glutethimide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with efavirenz.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with indapamide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with dipyridamole.", "severity": 2}
{"drug1": "Etomidate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with clonidine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with tizanidine.", "severity": 2}
{"drug1": "codeine", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with secobarbital.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with mesoridazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Perospirone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Lorcaserin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Remoxipride.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with carisoprodol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Salbutamol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with SERATRODAST.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with sulpiride.", "severity": 2}
{"drug1": "dyclonine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with tizanidine.", "severity": 2}
{"drug1": "loxapine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with oxycodone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Aceclofenac.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with DESONIDE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Pipamperone.", "severity": 2}
{"drug1": "midazolam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with topiramate.", "severity": 2}
{"drug1": "etodolac", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Estrone sulfate.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with quetiapine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "cimetidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atorvastatin is combined with cimetidine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with pimozide.", "severity": 2}
{"drug1": "pramipexole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with nicardipine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "cilazapril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with meperidine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with sumatriptan.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with barnidipine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Empagliflozin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with indomethacin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with metolazone.", "severity": 2}
{"drug1": "butenafine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with nisoldipine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with mepivacaine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with paramethasone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Desloratadine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Aliskiren.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Butethal", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Aliskiren.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with nalidixic acid.", "severity": 2}
{"drug1": "ondansetron", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with fexofenadine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with trichlormethiazide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with olanzapine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Nebivolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with sertraline.", "severity": 2}
{"drug1": "ketorolac", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with difluprednate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with halcinonide.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when daunorubicin is combined with atorvastatin.", "severity": 2}
{"drug1": "benazepril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with alclometasone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with doxepin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with paramethasone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "floctafenine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with betamethasone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with sotalol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with floctafenine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with malathion.", "severity": 2}
{"drug1": "flunarizine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with simvastatin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "methotrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfadiazine is combined with methotrexate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Mephobarbital.", "severity": 2}
{"drug1": "meprobamate", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Pipamperone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ambroxol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with fleroxacin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Lormetazepam.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with fexofenadine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with metoclopramide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with atenolol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Pimecrolimus.", "severity": 2}
{"drug1": "ipratropium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with butorphanol.", "severity": 2}
{"drug1": "estazolam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with MOLINDONE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with chlorprothixene.", "severity": 2}
{"drug1": "estazolam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Aceprometazine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with haloperidol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with acemetacin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with proparacaine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "methoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with methoxamine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Halazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with terbutaline.", "severity": 2}
{"drug1": "clorazepate", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with tiagabine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with brimonidine.", "severity": 2}
{"drug1": "loratadine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with GUANFACINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Eprosartan.", "severity": 2}
{"drug1": "alprazolam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with butalbital.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with meclizine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with brotizolam.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with isoxsuprine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with diltiazem.", "severity": 2}
{"drug1": "loratadine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Olopatadine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with valsartan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with indapamide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with proparacaine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sorafenib is combined with leflunomide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Halazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ALFENTANIL.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with ramipril.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Enasidenib.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Asenapine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with bumetanide.", "severity": 2}
{"drug1": "miconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with fludiazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with trifluoperazine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when anagrelide is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with scopolamine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with 4-PHENYLBUTYRIC ACID.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Pralatrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Pralatrexate.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "methoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with methoxamine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with hydralazine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "moclobemide", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with droxidopa.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nitroglycerin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with lisinopril.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with metolazone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with proparacaine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Halazepam.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with risperidone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Pomalidomide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Oxetacaine.", "severity": 2}
{"drug1": "quinapril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with suprofen.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Butethal.", "severity": 2}
{"drug1": "sotalol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with tizanidine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with lithium ion.", "severity": 2}
{"drug1": "benztropine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with oxycodone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Pramocaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Aripiprazole.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Articaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with HEROIN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with sertraline.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with irbesartan.", "severity": 2}
{"drug1": "enflurane", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with oxprenolol.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Pizotifen.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with perphenazine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with desipramine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Remoxipride.", "severity": 2}
{"drug1": "methysergide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Lurasidone.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lopinavir is combined with toremifene.", "severity": 2}
{"drug1": "methysergide", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Ticagrelor.", "severity": 2}
{"drug1": "methysergide", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with tofisopam.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with maprotiline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Arformoterol.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lopinavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with flunarizine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Levomepromazine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with trifluoperazine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Etoricoxib.", "severity": 2}
{"drug1": "benzocaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "benzocaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with duloxetine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ketamine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Desloratadine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with fluoxetine.", "severity": 2}
{"drug1": "butamben", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with phenytoin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Iloperidone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Perospirone.", "severity": 2}
{"drug1": "cetirizine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with nefazodone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with acetylcholine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Tolcapone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Iloperidone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with isoxsuprine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Pipamperone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with levorphanol.", "severity": 2}
{"drug1": "pimozide", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with oxprenolol.", "severity": 2}
{"drug1": "cetirizine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Cariprazine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Salbutamol.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with flunarizine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with desipramine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with nimesulide.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with clonidine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with selegiline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with SUFENTANIL.", "severity": 2}
{"drug1": "nicergoline", "drug2": "itraconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with itraconazole.", "severity": 2}
{"drug1": "nicergoline", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with cilostazol.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with lovastatin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Clodronic Acid.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with loratadine.", "severity": 2}
{"drug1": "clozapine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with selegiline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with ethosuximide.", "severity": 2}
{"drug1": "prazosin", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with dipyridamole.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with levodopa.", "severity": 2}
{"drug1": "gabapentin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with butamben.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Asenapine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with norfloxacin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with HEROIN.", "severity": 2}
{"drug1": "quazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Remoxipride.", "severity": 2}
{"drug1": "reserpine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with loxapine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with Echothiophate.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with dipyridamole.", "severity": 2}
{"drug1": "codeine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Fospropofol.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Ketobemidone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Articaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with timolol.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with dipyridamole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with vigabatrin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with flunitrazepam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Propoxycaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Pomalidomide.", "severity": 2}
{"drug1": "methadone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with mesoridazine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Eszopiclone.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Bambuterol.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with desipramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nisoldipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with butalbital.", "severity": 2}
{"drug1": "pergolide", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with antipyrine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Fospropofol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Flupentixol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with METAXALONE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with VERAPAMIL.", "severity": 2}
{"drug1": "quazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "quazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with zotepine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with amisulpride.", "severity": 2}
{"drug1": "pergolide", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with modafinil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with etizolam.", "severity": 2}
{"drug1": "pergolide", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with hydrocortisone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Pipamperone.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BOPINDOLOL is combined with Cevimeline.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BOPINDOLOL is combined with nicotine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with meclizine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Pizotifen.", "severity": 2}
{"drug1": "midodrine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with nylidrin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Levetiracetam.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nadolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with sulfanilamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Fencamfamin.", "severity": 2}
{"drug1": "terazosin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with isoxsuprine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with felbamate.", "severity": 2}
{"drug1": "alclometasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "halothane", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Normethadone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with cilazapril.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with butamben.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Almotriptan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nadolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with ESMOLOL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with atenolol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with doxepin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with DESONIDE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with NAPROXEN.", "severity": 2}
{"drug1": "halothane", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Pomalidomide.", "severity": 2}
{"drug1": "midazolam", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with risperidone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "midazolam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with meclizine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Pizotifen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with acemetacin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "quazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with procaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tiapride.", "severity": 2}
{"drug1": "quazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with prazepam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with triprolidine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with methocarbamol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with spironolactone.", "severity": 2}
{"drug1": "meclizine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "epirizole", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with flurandrenolide.", "severity": 2}
{"drug1": "isradipine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with mecamylamine.", "severity": 2}
{"drug1": "captopril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Nepafenac.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Olopatadine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with brimonidine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Nabilone.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with pravastatin.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with zonisamide.", "severity": 2}
{"drug1": "midodrine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with sotalol.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "baclofen", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with ALFENTANIL.", "severity": 2}
{"drug1": "meperidine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with daunorubicin.", "severity": 2}
{"drug1": "amifostine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with bupivacaine.", "severity": 2}
{"drug1": "amifostine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Ropivacaine.", "severity": 2}
{"drug1": "biperiden", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with hyoscyamine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Desloratadine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with lisinopril.", "severity": 2}
{"drug1": "lisinopril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with quetiapine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with nitroglycerin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with trifluoperazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with leflunomide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with floctafenine.", "severity": 2}
{"drug1": "methadone", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Potassium citrate.", "severity": 2}
{"drug1": "Apremilast", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Pramocaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Propoxycaine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Arformoterol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with prilocaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Cyamemazine.", "severity": 2}
{"drug1": "buspirone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with oxycodone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with chlormezanone.", "severity": 2}
{"drug1": "ethotoin", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with zonisamide.", "severity": 2}
{"drug1": "tinidazole", "drug2": "disulfiram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tinidazole is combined with disulfiram.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Etoricoxib.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with Tramadol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with methoxyflurane.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with quetiapine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with formestane.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Iloperidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Fulvestrant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Fulvestrant.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with antipyrine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with MOLINDONE.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with resveratrol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with penbutolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nicotinamide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Aceprometazine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with trandolapril.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with bumetanide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with chlorothiazide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Vorinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Vorinostat.", "severity": 2}
{"drug1": "oxycodone", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with trazodone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with gemfibrozil.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with benazepril.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with vincristine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with BISOPROLOL.", "severity": 2}
{"drug1": "biperiden", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Propiverine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with docetaxel.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with methyclothiazide.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Clevidipine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with butalbital.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with chlorothiazide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with potassium ion.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with brotizolam.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Canrenoic acid.", "severity": 2}
{"drug1": "apomorphine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with halothane.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Empagliflozin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Etidocaine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Empagliflozin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Droxicam.", "severity": 2}
{"drug1": "difluprednate", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with donepezil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with triprolidine.", "severity": 2}
{"drug1": "atenolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with fluoxetine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Olopatadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with physostigmine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Mometasone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with bromazepam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with secobarbital.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with protriptyline.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with rivastigmine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "methysergide", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ambroxol.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Droxicam.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with tolfenamic acid.", "severity": 2}
{"drug1": "reserpine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Torasemide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Loxoprofen.", "severity": 2}
{"drug1": "nimodipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with furosemide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with haloperidol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Aceclofenac.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyzine is combined with sertraline.", "severity": 2}
{"drug1": "diltiazem", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with labetalol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with physostigmine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with terazosin.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with venlafaxine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with amitriptyline.", "severity": 2}
{"drug1": "suprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with ibuprofen.", "severity": 2}
{"drug1": "nimodipine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "suprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with galanthamine.", "severity": 2}
{"drug1": "losartan", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Deferasirox.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with clidinium.", "severity": 2}
{"drug1": "alprazolam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with tetracaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with thiopental.", "severity": 2}
{"drug1": "thioridazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with amobarbital.", "severity": 2}
{"drug1": "methysergide", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with gemfibrozil.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Hexobarbital.", "severity": 2}
{"drug1": "zaleplon", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with lithium ion.", "severity": 2}
{"drug1": "zaleplon", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with etizolam.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with SERATRODAST.", "severity": 2}
{"drug1": "methysergide", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with docetaxel.", "severity": 2}
{"drug1": "Spirapril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with ketoprofen.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with lithium ion.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Riociguat.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Hexobarbital.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Butethal.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Flibanserin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with amobarbital.", "severity": 2}
{"drug1": "pentazocine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with carprofen.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nicardipine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with chlorothiazide.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Butethal.", "severity": 2}
{"drug1": "bumetanide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "nimodipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with sotalol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with trandolapril.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Butethal.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Aliskiren.", "severity": 2}
{"drug1": "haloperidol", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with amobarbital.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Topiroxostat.", "severity": 2}
{"drug1": "tiapride", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with scopolamine.", "severity": 2}
{"drug1": "prazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with imipramine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Nebivolol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Etomidate", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with butamben.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Etoricoxib.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Lumiracoxib.", "severity": 2}
{"drug1": "reserpine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Nelarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Nelarabine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with tamoxifen.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with clonidine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with doxepin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with estrone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Ketobemidone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with furosemide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with flunarizine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with brotizolam.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Tolvaptan.", "severity": 2}
{"drug1": "benztropine", "drug2": "trihexyphenidyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with trihexyphenidyl.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "thiotepa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with thiotepa.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with clidinium.", "severity": 2}
{"drug1": "diazepam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with oxymorphone.", "severity": 2}
{"drug1": "tioconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with barnidipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Eplerenone.", "severity": 2}
{"drug1": "pargyline", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with brimonidine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with perphenazine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with chlorthalidone.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with equilin.", "severity": 2}
{"drug1": "prazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with butorphanol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Desloratadine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Telmisartan.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with PAMABROM.", "severity": 2}
{"drug1": "nicardipine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with sertraline.", "severity": 2}
{"drug1": "morphine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with lidocaine.", "severity": 2}
{"drug1": "procaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with HEROIN.", "severity": 2}
{"drug1": "imipramine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with methyldopa.", "severity": 2}
{"drug1": "oxycodone", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with potassium ion.", "severity": 2}
{"drug1": "glutethimide", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Butethal", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Tasimelteon.", "severity": 2}
{"drug1": "cabergoline", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with zolmitriptan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with acetaminophen.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with metaproterenol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "propantheline", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Metixene.", "severity": 2}
{"drug1": "diclofenac", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with resveratrol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with bromazepam.", "severity": 2}
{"drug1": "promazine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with zaleplon.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Normethadone.", "severity": 2}
{"drug1": "promazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Desloratadine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Pipotiazine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Fluprednidene.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Levobupivacaine.", "severity": 2}
{"drug1": "morphine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with isoflurane.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "morphine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with tretinoin.", "severity": 2}
{"drug1": "morphine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ethotoin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with amisulpride.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Normethadone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with polythiazide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with terazosin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Mersalyl.", "severity": 2}
{"drug1": "antipyrine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Salmeterol.", "severity": 2}
{"drug1": "cocaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with tiagabine.", "severity": 2}
{"drug1": "ramipril", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with atenolol.", "severity": 2}
{"drug1": "bepridil", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with triamterene.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with GUANFACINE.", "severity": 2}
{"drug1": "meclizine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with vigabatrin.", "severity": 2}
{"drug1": "papaverine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with terazosin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Propacetamol.", "severity": 2}
{"drug1": "enalapril", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with mecamylamine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with Temsirolimus.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Tolcapone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Pipotiazine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Nitroprusside.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with brotizolam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Thioproperazine.", "severity": 2}
{"drug1": "josamycin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when josamycin is combined with atorvastatin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Gatifloxacin.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with memantine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with Normethadone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Propacetamol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with amisulpride.", "severity": 2}
{"drug1": "Nabilone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with rasagiline.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Risedronic acid.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with bumetanide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with felodipine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with promethazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Clevidipine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "tetracaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with zotepine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with nadolol.", "severity": 2}
{"drug1": "citalopram", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Tapentadol.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Escitalopram.", "severity": 2}
{"drug1": "loxapine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with buspirone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with chloroquine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with butalbital.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with zaltoprofen.", "severity": 2}
{"drug1": "risperidone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with methoxyflurane.", "severity": 2}
{"drug1": "clonidine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with losartan.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "loxapine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with diazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with quetiapine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with terazosin.", "severity": 2}
{"drug1": "Triflusal", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with tiapride.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with ketoprofen.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with levodopa.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Apremilast.", "severity": 2}
{"drug1": "trazodone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with selegiline.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with pramipexole.", "severity": 2}
{"drug1": "prazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Lofexidine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with clidinium.", "severity": 2}
{"drug1": "estazolam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with etizolam.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "dienestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with dienestrol.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with GUANFACINE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with dipyridamole.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Tramadol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Zoledronic acid.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with doxepin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with cetirizine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with clemastine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with diflorasone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with rasagiline.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with nefazodone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with donepezil.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with flurbiprofen.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with budesonide.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Levetiracetam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with chloramphenicol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with lisinopril.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Tixocortol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "propofol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with promethazine.", "severity": 2}
{"drug1": "propofol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with clonazepam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with efavirenz.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with scopolamine.", "severity": 2}
{"drug1": "propranolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with hydralazine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Varenicline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with metolazone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Lornoxicam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with scopolamine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Fesoterodine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Pramocaine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with felbamate.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Lercanidipine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with zotepine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with MELPERONE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with mecamylamine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with codeine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with MOLINDONE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with quetiapine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Nabilone", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with ESMOLOL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with furosemide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with tizanidine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with midazolam.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with valsartan.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with ramipril.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Apremilast.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with HEROIN.", "severity": 2}
{"drug1": "codeine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with nitrous oxide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with butalbital.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Normethadone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Metipranolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Paliperidone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with thiopental.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with AMILORIDE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with ethosuximide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ondansetron.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Tolcapone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Pipamperone.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with pyridostigmine.", "severity": 2}
{"drug1": "promazine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with triprolidine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Lurasidone.", "severity": 2}
{"drug1": "promazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with methocarbamol.", "severity": 2}
{"drug1": "promazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with methylphenidate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with desipramine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with thiamylal.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Desloratadine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Ramelteon.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with tiapride.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with codeine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with Pefloxacin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with isocarboxazid.", "severity": 2}
{"drug1": "bromazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with hydrocortisone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with benzocaine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with HEROIN.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with dantrolene.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with alclometasone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Cariprazine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Levocetirizine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "azathioprine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azathioprine is combined with leflunomide.", "severity": 2}
{"drug1": "loxapine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with clonazepam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with citalopram.", "severity": 2}
{"drug1": "benazepril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with nimesulide.", "severity": 2}
{"drug1": "loxapine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Melatonin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with meclizine.", "severity": 2}
{"drug1": "butenafine", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with manidipine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Pomalidomide.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with dipyridamole.", "severity": 2}
{"drug1": "chloroquine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with estrone.", "severity": 2}
{"drug1": "enalapril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Flibanserin.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "oxazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with amoxapine.", "severity": 2}
{"drug1": "propantheline", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Tapentadol.", "severity": 2}
{"drug1": "desipramine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Milnacipran.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Aceprometazine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with nimesulide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Pizotifen.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with MOLINDONE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with doxepin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Iloperidone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Oxetacaine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with floctafenine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Canagliflozin.", "severity": 2}
{"drug1": "triazolam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with etizolam.", "severity": 2}
{"drug1": "meperidine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Pizotifen.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Lomitapide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Lurasidone.", "severity": 2}
{"drug1": "valsartan", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with nimodipine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with tubocurarine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Lornoxicam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with quetiapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "triprolidine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with clonidine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with physostigmine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Escitalopram.", "severity": 2}
{"drug1": "lidocaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with efavirenz.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Fencamfamin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with ethosuximide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with lomustine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with mitoxantrone.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Propacetamol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with ketamine.", "severity": 2}
{"drug1": "captopril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "codeine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with olanzapine.", "severity": 2}
{"drug1": "indapamide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with fexofenadine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with tranylcypromine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with methylprednisolone.", "severity": 2}
{"drug1": "pergolide", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with ifosfamide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with fludrocortisone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "propantheline", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with flurbiprofen.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with triflupromazine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Pomalidomide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with pyridostigmine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "triazolam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with butamben.", "severity": 2}
{"drug1": "thiopental", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Pizotifen.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with nefazodone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with nefazodone.", "severity": 2}
{"drug1": "prazosin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with captopril.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nilotinib is combined with leflunomide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with carisoprodol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Flibanserin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with zaleplon.", "severity": 2}
{"drug1": "tizanidine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with meclizine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Desloratadine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with venlafaxine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with resveratrol.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with isoproterenol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with indapamide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Olmesartan.", "severity": 2}
{"drug1": "clozapine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with topiramate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "citalopram", "drug2": "Eletriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Eletriptan.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with celecoxib.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with acebutolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Aliskiren.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with captopril.", "severity": 2}
{"drug1": "butabarbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with isocarboxazid.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with methyclothiazide.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with isradipine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with gemfibrozil.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with epoprostenol.", "severity": 2}
{"drug1": "codeine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with thiopental.", "severity": 2}
{"drug1": "amisulpride", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with vigabatrin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Pipotiazine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with thiothixene.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Aliskiren.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Flibanserin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with fenbufen.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with duloxetine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "temazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with gabapentin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with cinoxacin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with Milnacipran.", "severity": 2}
{"drug1": "docetaxel", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with fleroxacin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with diflorasone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "thiotepa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with thiotepa.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with fludrocortisone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with cetirizine.", "severity": 2}
{"drug1": "biperiden", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Tramadol.", "severity": 2}
{"drug1": "buspirone", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with pentazocine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with haloperidol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Normethadone.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with ALFENTANIL.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with triprolidine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Cariprazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with methocarbamol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with meclizine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with doxepin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "levorphanol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with GUANFACINE.", "severity": 2}
{"drug1": "butenafine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with homoharringtonine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with dexamethasone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with ibuprofen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with CLONIXIN.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with apraclonidine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with sertraline.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with triazolam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with pentazocine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with thiamylal.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with desipramine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Fluspirilene.", "severity": 2}
{"drug1": "selegiline", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with dobutamine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with chlorothiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with OLODATEROL.", "severity": 2}
{"drug1": "valsartan", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with indapamide.", "severity": 2}
{"drug1": "amisulpride", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with chlorzoxazone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with bumetanide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "estazolam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with clidinium.", "severity": 2}
{"drug1": "methysergide", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with lansoprazole.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with carisoprodol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with nefazodone.", "severity": 2}
{"drug1": "loxapine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ramipril", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nimodipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with chlorthalidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with trimipramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nitroglycerin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "reserpine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with lisinopril.", "severity": 2}
{"drug1": "reserpine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with procaine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with dichlorphenamide.", "severity": 2}
{"drug1": "captopril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "cetirizine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with halothane.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Bretylium.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with hydrocortisone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with trimipramine.", "severity": 2}
{"drug1": "meclizine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with venlafaxine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with procaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with felbamate.", "severity": 2}
{"drug1": "benazepril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ADAPALENE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with efavirenz.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Clobetasone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with thiothixene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with methylprednisolone.", "severity": 2}
{"drug1": "metaraminol", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with atorvastatin.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with PERHEXILINE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with tolmetin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with haloperidol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with chlorprothixene.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with clonidine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with apraclonidine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with oxaprozin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "prazosin", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "methysergide", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with manidipine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with felbamate.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Isoflurophate.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with hydromorphone.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Levocetirizine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with maprotiline.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with enalapril.", "severity": 2}
{"drug1": "budesonide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with metoclopramide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Fesoterodine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Deferasirox.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "captopril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with nimesulide.", "severity": 2}
{"drug1": "isradipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with papaverine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with D-mannitol.", "severity": 2}
{"drug1": "isradipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with nifedipine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ZILEUTON.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with etodolac.", "severity": 2}
{"drug1": "oxycodone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with nitrous oxide.", "severity": 2}
{"drug1": "cocaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Difenoxin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "timolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "aminophylline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aminophylline is combined with OLODATEROL.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tobramycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with tobramycin.", "severity": 2}
{"drug1": "carprofen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Halobetasol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ritodrine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with benzocaine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with terazosin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Cariprazine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Sunitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Temsirolimus is combined with Sunitinib.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Perospirone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "olanzapine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "benazepril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with terazosin.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with morphine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Deferasirox.", "severity": 2}
{"drug1": "sulindac", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Clobetasone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with loratadine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with imipramine.", "severity": 2}
{"drug1": "suprofen", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Canagliflozin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with felodipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with mycophenolic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with triamcinolone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with clonidine.", "severity": 2}
{"drug1": "meclizine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Tasimelteon.", "severity": 2}
{"drug1": "estrone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "midazolam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with HEROIN.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with equilin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Butethal.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiopental", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with lithium ion.", "severity": 2}
{"drug1": "thiopental", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Hexobarbital.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with tioconazole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with etizolam.", "severity": 2}
{"drug1": "timolol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with felodipine.", "severity": 2}
{"drug1": "timolol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Bretylium.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Riociguat.", "severity": 2}
{"drug1": "timolol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with irbesartan.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with haloperidol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Amrinone.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with zonisamide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with gabapentin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with fosinopril.", "severity": 2}
{"drug1": "ethanol", "drug2": "nicotinic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with nicotinic acid.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with tiagabine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with levodopa.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with deslanoside.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Salsalate.", "severity": 2}
{"drug1": "difluprednate", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with galanthamine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Ketobemidone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Isoflurophate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Ketobemidone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Tasimelteon.", "severity": 2}
{"drug1": "procaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Pramocaine.", "severity": 2}
{"drug1": "procaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lopinavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "oxycodone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with DEZOCINE.", "severity": 2}
{"drug1": "Butethal", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with levodopa.", "severity": 2}
{"drug1": "terbinafine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "baclofen", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with citalopram.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with amoxapine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with penbutolol.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxychloroquine is combined with dapsone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Lormetazepam.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Articaine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with sumatriptan.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Hexobarbital.", "severity": 2}
{"drug1": "butabarbital", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with lithium ion.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Milnacipran.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Lormetazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with amobarbital.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Butethal.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Halazepam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with efavirenz.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with cilostazol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with methylprednisolone.", "severity": 2}
{"drug1": "atenolol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with apraclonidine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Levocetirizine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with meclizine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with methyclothiazide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nevirapine is combined with Flibanserin.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Pipamperone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with promazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Iloperidone.", "severity": 2}
{"drug1": "meperidine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Asenapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "meperidine", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Tolvaptan.", "severity": 2}
{"drug1": "cocaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with tiagabine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with clomipramine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with antipyrine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Desloratadine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with apraclonidine.", "severity": 2}
{"drug1": "Pemetrexed", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pemetrexed is combined with leflunomide.", "severity": 2}
{"drug1": "tetracaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with nortriptyline.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with buprenorphine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with amoxapine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with levodopa.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with decamethonium.", "severity": 2}
{"drug1": "milrinone", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with aspirin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Pemetrexed", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Pemetrexed.", "severity": 2}
{"drug1": "docetaxel", "drug2": "mebendazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with mebendazole.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with dantrolene.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with citalopram.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with doxepin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with cetirizine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Amrinone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Flibanserin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with furosemide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with chlormezanone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with fludrocortisone.", "severity": 2}
{"drug1": "reserpine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with papaverine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with phentolamine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with benazepril.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with glutethimide.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with sertraline.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Methadyl acetate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with hydralazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Milnacipran.", "severity": 2}
{"drug1": "pimozide", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Halazepam.", "severity": 2}
{"drug1": "bepridil", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with isoxsuprine.", "severity": 2}
{"drug1": "pimozide", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with proparacaine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with lovastatin.", "severity": 2}
{"drug1": "promazine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with chlormezanone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "levodopa", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with moclobemide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Halazepam.", "severity": 2}
{"drug1": "levodopa", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Escitalopram.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with risperidone.", "severity": 2}
{"drug1": "diazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with SERATRODAST.", "severity": 2}
{"drug1": "sulfapyridine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfapyridine is combined with mecamylamine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Metipranolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with brimonidine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Bambuterol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with DEZOCINE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with benazepril.", "severity": 2}
{"drug1": "pargyline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with clenbuterol.", "severity": 2}
{"drug1": "methadone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Cis-mdp.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with morphine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with lovastatin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with fosinopril.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Normethadone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with oxprenolol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with apraclonidine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "nicardipine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with methyldopa.", "severity": 2}
{"drug1": "cilazapril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with niflumic acid.", "severity": 2}
{"drug1": "rasagiline", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with zotepine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "carprofen", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with ibuprofen.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Clevidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with ILOPROST.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Naftifine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with trazodone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with thalidomide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with tiagabine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with meclizine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with acemetacin.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with carvedilol.", "severity": 2}
{"drug1": "diazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Teriflunomide.", "severity": 2}
{"drug1": "baclofen", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with maprotiline.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with ondansetron.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with dantrolene.", "severity": 2}
{"drug1": "sulpiride", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with chloral hydrate.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nitroglycerin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with fludiazepam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with lisinopril.", "severity": 2}
{"drug1": "lisinopril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with resveratrol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with desipramine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with thioridazine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with ALFENTANIL.", "severity": 2}
{"drug1": "buspirone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with DEZOCINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Retigabine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with azelastine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Ezetimibe.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with dipyridamole.", "severity": 2}
{"drug1": "reserpine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chlorprothixene.", "severity": 2}
{"drug1": "procyclidine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with scopolamine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with benazepril.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with vincristine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Empagliflozin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Icatibant.", "severity": 2}
{"drug1": "sulindac", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with haloperidol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with nimesulide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paricalcitol is combined with Calcifediol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tofisopam.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with Escitalopram.", "severity": 2}
{"drug1": "terconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with dantrolene.", "severity": 2}
{"drug1": "ketamine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Eprosartan.", "severity": 2}
{"drug1": "clonidine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ketamine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with glutethimide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Conivaptan.", "severity": 2}
{"drug1": "Torasemide", "drug2": "plicamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with plicamycin.", "severity": 2}
{"drug1": "reserpine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with sevoflurane.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Teriflunomide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with timolol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with etizolam.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with flurandrenolide.", "severity": 2}
{"drug1": "prazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "propofol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Eprosartan.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with minoxidil.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Pomalidomide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with mefloquine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Etoricoxib.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with METAXALONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with topiramate.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Pipamperone.", "severity": 2}
{"drug1": "scopolamine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with fluoxetine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Loxoprofen.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Droxicam.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with ropinirole.", "severity": 2}
{"drug1": "resveratrol", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with CLONIXIN.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with metoprolol.", "severity": 2}
{"drug1": "diflunisal", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with triamcinolone.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with nisoldipine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Empagliflozin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with difluprednate.", "severity": 2}
{"drug1": "isoflurane", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with zonisamide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with triamterene.", "severity": 2}
{"drug1": "acebutolol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with nadolol.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Lormetazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Difenoxin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Aceclofenac.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Tapentadol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Ramelteon.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Ramelteon.", "severity": 2}
{"drug1": "prilocaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with HEROIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with tiapride.", "severity": 2}
{"drug1": "Icatibant", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with carisoprodol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with zopiclone.", "severity": 2}
{"drug1": "hexetidine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Varenicline.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nitric oxide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Tolvaptan.", "severity": 2}
{"drug1": "Articaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with duloxetine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Asenapine.", "severity": 2}
{"drug1": "Articaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with fluoxetine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with trimipramine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Milnacipran.", "severity": 2}
{"drug1": "flurazepam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "atenolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Difenoxin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Masoprocol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ramipril.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Oxetacaine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with estrone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with eperisone.", "severity": 2}
{"drug1": "atenolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Metipranolol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Tolcapone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with nicardipine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with acetylcholine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Articaine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with SERATRODAST.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Atracurium besylate.", "severity": 2}
{"drug1": "levorphanol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with benzocaine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Droxicam.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with tolfenamic acid.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Loxoprofen.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Telmisartan.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Droxicam.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with CLONIXIN.", "severity": 2}
{"drug1": "Naftifine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with homoharringtonine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with apraclonidine.", "severity": 2}
{"drug1": "butenafine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with nifedipine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "codeine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with tetracaine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with efavirenz.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Stepronin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Stepronin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with diazepam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "triazolam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with citalopram.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with citalopram.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with HYDROCODONE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Tadalafil.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Elbasvir.", "severity": 2}
{"drug1": "lorazepam", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with clorazepate.", "severity": 2}
{"drug1": "metolazone", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with carbamazepine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with trimipramine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with spironolactone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with clemastine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "azelastine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with dexamethasone.", "severity": 2}
{"drug1": "Perampanel", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with duloxetine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Perospirone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Perampanel", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with fluoxetine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with amcinonide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with CLONIXIN.", "severity": 2}
{"drug1": "methysergide", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nicotinamide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trabectedin is combined with clozapine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with oxybutynin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with ethotoin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Fluprednidene.", "severity": 2}
{"drug1": "salicylamide", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with butalbital.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Pipamperone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with triflupromazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Olmesartan.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with tizanidine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with isradipine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with haloperidol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ritonavir.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with oxybutynin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with anastrozole.", "severity": 2}
{"drug1": "Etomidate", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with prazepam.", "severity": 2}
{"drug1": "erythromycin", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when erythromycin is combined with oxycodone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with KETAZOLAM.", "severity": 2}
{"drug1": "reserpine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with prazepam.", "severity": 2}
{"drug1": "carprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Ramelteon.", "severity": 2}
{"drug1": "betamethasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with mefloquine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with metaproterenol.", "severity": 2}
{"drug1": "carprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with topiramate.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with buprenorphine.", "severity": 2}
{"drug1": "propofol", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Olmesartan.", "severity": 2}
{"drug1": "phentolamine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bivalirudin is combined with Temsirolimus.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with METAXALONE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with metolazone.", "severity": 2}
{"drug1": "triazolam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with mepivacaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with zaleplon.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with dibucaine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Apremilast.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with zonisamide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with tolfenamic acid.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with tiagabine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with duloxetine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with fluoxetine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ESMOLOL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ethchlorvynol.", "severity": 2}
{"drug1": "loxapine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Ramelteon.", "severity": 2}
{"drug1": "azelastine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with desoximetasone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with niflumic acid.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with nefazodone.", "severity": 2}
{"drug1": "donepezil", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when donepezil is combined with acetylcholine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with atorvastatin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Propacetamol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with carvedilol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "floxuridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with floxuridine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with vigabatrin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with pentazocine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with morphine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with VERAPAMIL.", "severity": 2}
{"drug1": "amiodarone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with terazosin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Potassium citrate.", "severity": 2}
{"drug1": "medrysone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Isoflurophate.", "severity": 2}
{"drug1": "medrysone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with galanthamine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Lercanidipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with methyclothiazide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with metolazone.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Clevidipine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with nimodipine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Aceprometazine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with SERATRODAST.", "severity": 2}
{"drug1": "propofol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with valsartan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with ramipril.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Articaine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with equilin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Flibanserin.", "severity": 2}
{"drug1": "risperidone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with MOLINDONE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with fenbufen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with zaltoprofen.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with methadone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with oxprenolol.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with fexofenadine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Butethal", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with clonidine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with metoprolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Fluspirilene.", "severity": 2}
{"drug1": "cabergoline", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ketamine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "amifostine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Rotigotine.", "severity": 2}
{"drug1": "codeine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Ropivacaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with propofol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with acetazolamide.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Ramelteon.", "severity": 2}
{"drug1": "bromazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with benzocaine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Hexobarbital.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with captopril.", "severity": 2}
{"drug1": "codeine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with trifluoperazine.", "severity": 2}
{"drug1": "azelastine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with fluocinonide.", "severity": 2}
{"drug1": "labetalol", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with PROCATEROL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with pilocarpine.", "severity": 2}
{"drug1": "morphine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Remoxipride.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Bretylium.", "severity": 2}
{"drug1": "morphine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with tiapride.", "severity": 2}
{"drug1": "meperidine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with duloxetine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with atenolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with sevoflurane.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with ropinirole.", "severity": 2}
{"drug1": "morphine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Etidocaine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Pipamperone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Propoxycaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with topiramate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "pentazocine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "topiramate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with clomipramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nitric oxide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with nicardipine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with dexamethasone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Phenelzine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with carprofen.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Normethadone.", "severity": 2}
{"drug1": "meclizine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with promethazine.", "severity": 2}
{"drug1": "meclizine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with clonazepam.", "severity": 2}
{"drug1": "antipyrine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with resveratrol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with maprotiline.", "severity": 2}
{"drug1": "phentolamine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "bromazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with flurandrenolide.", "severity": 2}
{"drug1": "metaraminol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with acebutolol.", "severity": 2}
{"drug1": "temazepam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with ketamine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfacetamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfacetamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Aliskiren.", "severity": 2}
{"drug1": "milrinone", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "imipramine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with rasagiline.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with hydralazine.", "severity": 2}
{"drug1": "miconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "miconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Desloratadine.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with eperisone.", "severity": 2}
{"drug1": "valsartan", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ADAPALENE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with alclofenac.", "severity": 2}
{"drug1": "Normethadone", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with phenytoin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Deferasirox.", "severity": 2}
{"drug1": "quinidine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with methscopolamine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Pefloxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Almotriptan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with sotalol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with clomipramine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Oxetacaine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with homoharringtonine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "glimepiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with glimepiride.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with diflorasone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with equilin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Agomelatine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with desoximetasone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with flumethasone.", "severity": 2}
{"drug1": "epirizole", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with estrone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Etomidate.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "etizolam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with clomipramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Ropivacaine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritonavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "irinotecan", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irinotecan is combined with atorvastatin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with penbutolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Mephobarbital.", "severity": 2}
{"drug1": "Torasemide", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with indapamide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with nitrazepam.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with ketoprofen.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with nalbuphine.", "severity": 2}
{"drug1": "pergolide", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with isoniazid.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with thalidomide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with clomipramine.", "severity": 2}
{"drug1": "pergolide", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with methylprednisolone.", "severity": 2}
{"drug1": "morniflumate", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with ketoprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Milnacipran.", "severity": 2}
{"drug1": "prilocaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with primidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with mepivacaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with methazolamide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with amcinonide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Pizotifen.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Icatibant", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Nepafenac.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with procarbazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "colchicine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with colchicine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with diflunisal.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with nadolol.", "severity": 2}
{"drug1": "clozapine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with nimesulide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with ethotoin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with DESFLURANE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with clomipramine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Ziprasidone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Enalaprilat.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Tolcapone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Desloratadine.", "severity": 2}
{"drug1": "midazolam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with mepivacaine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with HEROIN.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with flunarizine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with dibucaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with indomethacin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Articaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with CARTEOLOL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with scopolamine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with morphine.", "severity": 2}
{"drug1": "temazepam", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with midazolam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with isocarboxazid.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Retigabine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Pizotifen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with fexofenadine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with betamethasone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Oxetacaine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with halcinonide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "clozapine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nisoldipine.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telithromycin is combined with oxycodone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Propacetamol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Eszopiclone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with butalbital.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Lornoxicam.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with sulpiride.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Risedronic acid.", "severity": 2}
{"drug1": "estazolam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with DEZOCINE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with loteprednol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with budesonide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with cetirizine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Levetiracetam.", "severity": 2}
{"drug1": "sulpiride", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with protriptyline.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with thiopental.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Phenelzine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with tetracaine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Salsalate.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Pizotifen.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with amisulpride.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with quetiapine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "selegiline", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with nadolol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Olsalazine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with bumetanide.", "severity": 2}
{"drug1": "midazolam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with cetirizine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with HEROIN.", "severity": 2}
{"drug1": "Limaprost", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with aspirin.", "severity": 2}
{"drug1": "midazolam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with protriptyline.", "severity": 2}
{"drug1": "Limaprost", "drug2": "PHENPROCOUMON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with Pirlindole.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with meprobamate.", "severity": 2}
{"drug1": "terconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with felodipine.", "severity": 2}
{"drug1": "methadone", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with acetazolamide.", "severity": 2}
{"drug1": "codeine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with scopolamine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with tretinoin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with vigabatrin.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Naftifine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with tiagabine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with zonisamide.", "severity": 2}
{"drug1": "chloroxine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with isradipine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with prazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with scopolamine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with metaproterenol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Tolcapone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with amitriptyline.", "severity": 2}
{"drug1": "loratadine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with dantrolene.", "severity": 2}
{"drug1": "ramipril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with meperidine.", "severity": 2}
{"drug1": "ramipril", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with prazosin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Thioproperazine.", "severity": 2}
{"drug1": "biperiden", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with DEZOCINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with thiopental.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Hexobarbital.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with lithium ion.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with felbamate.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Lormetazepam.", "severity": 2}
{"drug1": "procaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with tetracaine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Butethal.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Difenoxin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with lidocaine.", "severity": 2}
{"drug1": "quinapril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with celecoxib.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Flupentixol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Eprosartan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "propranolol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with nitroglycerin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with oxprenolol.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with halcinonide.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nilotinib is combined with Flibanserin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with difluprednate.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with quazepam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with prazepam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with hydralazine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nitroglycerin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Mometasone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Zoledronic acid.", "severity": 2}
{"drug1": "loxapine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with butamben.", "severity": 2}
{"drug1": "diazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Etomidate.", "severity": 2}
{"drug1": "diazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Ropivacaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with amoxapine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "captopril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Masoprocol.", "severity": 2}
{"drug1": "linezolid", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Frovatriptan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Droxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "irbesartan", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with tolfenamic acid.", "severity": 2}
{"drug1": "propantheline", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Ketobemidone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with papaverine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Deferasirox.", "severity": 2}
{"drug1": "imipramine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with CLONIXIN.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Tapentadol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Desloratadine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with amisulpride.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with morphine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with pimozide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with mepivacaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with vigabatrin.", "severity": 2}
{"drug1": "estazolam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with GUANFACINE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Pipamperone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Echothiophate.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with 3,4-Dihydroxybenzaldehyde.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Propacetamol.", "severity": 2}
{"drug1": "flumethasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with norfloxacin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with clonidine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with oxycodone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with scopolamine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Ramelteon.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with clidinium.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Butethal", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Pipamperone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "minoxidil", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with hydralazine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with propoxyphene.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with Levomilnacipran.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with tubocurarine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with captopril.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Eplerenone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with clonazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with doxepin.", "severity": 2}
{"drug1": "butamben", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with nortriptyline.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with loratadine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with ropinirole.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with oxaprozin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with isoproterenol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Melatonin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Flibanserin.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Ketobemidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Olopatadine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Varenicline.", "severity": 2}
{"drug1": "lisinopril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with SERATRODAST.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Clofarabine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with thalidomide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Aceclofenac.", "severity": 2}
{"drug1": "lisinopril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with zaltoprofen.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Pomalidomide.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with sertraline.", "severity": 2}
{"drug1": "suprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with fenoprofen.", "severity": 2}
{"drug1": "diazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with acetazolamide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfamethizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfamethizole.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Pizotifen.", "severity": 2}
{"drug1": "amifostine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with halothane.", "severity": 2}
{"drug1": "Propiverine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with amcinonide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with doxepin.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Iloperidone.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with sevoflurane.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Olmesartan.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Lofexidine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with isradipine.", "severity": 2}
{"drug1": "biperiden", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with quinidine.", "severity": 2}
{"drug1": "morphine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with fludiazepam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ESMOLOL.", "severity": 2}
{"drug1": "morphine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with zotepine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with amcinonide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with felbamate.", "severity": 2}
{"drug1": "amifostine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with bromocriptine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Bortezomib.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with hydralazine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with tiapride.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with theobromine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with flurbiprofen.", "severity": 2}
{"drug1": "thiothixene", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with trazodone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Sorafenib.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Milnacipran.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Tasimelteon.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with PROCATEROL.", "severity": 2}
{"drug1": "nylidrin", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nylidrin is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "haloperidol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with efavirenz.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with bupropion.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Clodronic Acid.", "severity": 2}
{"drug1": "clorazepate", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with MELPERONE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with zotepine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with DESONIDE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with isoxsuprine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Caspofungin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Caspofungin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with proparacaine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Lercanidipine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Flibanserin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Clobetasone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Mephobarbital.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with fexofenadine.", "severity": 2}
{"drug1": "thiopental", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with nefazodone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with carprofen.", "severity": 2}
{"drug1": "HEROIN", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with scopolamine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with phenytoin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with diflunisal.", "severity": 2}
{"drug1": "HEROIN", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with D-mannitol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with meclizine.", "severity": 2}
{"drug1": "timolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with hydralazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with tiapride.", "severity": 2}
{"drug1": "timolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Varenicline.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with butorphanol.", "severity": 2}
{"drug1": "atenolol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with flurandrenolide.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Lumiracoxib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "atenolol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "clozapine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with mefenamic acid.", "severity": 2}
{"drug1": "meprobamate", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with amitriptyline.", "severity": 2}
{"drug1": "Apremilast", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with formestane.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Tolcapone.", "severity": 2}
{"drug1": "morniflumate", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with alclofenac.", "severity": 2}
{"drug1": "methoxamine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with PROCATEROL.", "severity": 2}
{"drug1": "thalidomide", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with sotalol.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aprepitant is combined with oxycodone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with carvedilol.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "DAPTOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvastatin is combined with DAPTOMYCIN.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with methacholine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with bromocriptine.", "severity": 2}
{"drug1": "levodopa", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with lomustine.", "severity": 2}
{"drug1": "diazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with lithium ion.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Apremilast.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with duloxetine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nitric oxide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Desloratadine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Estrone sulfate.", "severity": 2}
{"drug1": "butenafine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with bepridil.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Levocetirizine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with alclofenac.", "severity": 2}
{"drug1": "promazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Pipamperone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Mephobarbital.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with quetiapine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with tiapride.", "severity": 2}
{"drug1": "enalapril", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with captopril.", "severity": 2}
{"drug1": "fenbufen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with bumetanide.", "severity": 2}
{"drug1": "furosemide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with tizanidine.", "severity": 2}
{"drug1": "furosemide", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with daunorubicin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with dantrolene.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with clonazepam.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with promethazine.", "severity": 2}
{"drug1": "triamterene", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with dichlorphenamide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with tizanidine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with prazepam.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with furosemide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with phentolamine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Zucapsaicin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with thiopental.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Almotriptan.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with ethosuximide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "dopamine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Aliskiren.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with methylprednisolone.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with tizanidine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Lornoxicam.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with pilocarpine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with quinapril.", "severity": 2}
{"drug1": "tetracaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with meclizine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with isoxsuprine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Apixaban.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Flupentixol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Pizotifen.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with CARTEOLOL.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with metolazone.", "severity": 2}
{"drug1": "reserpine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with felbamate.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Fospropofol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with ZILEUTON.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with phenytoin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with trazodone.", "severity": 2}
{"drug1": "quazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Asenapine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with diflorasone.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with difluprednate.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Iloperidone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with flunarizine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with isradipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Isometheptene.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when roxithromycin is combined with atorvastatin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Retigabine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Lacidipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with indapamide.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "ketorolac", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with astemizole.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Fluspirilene.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Tolcapone.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with methscopolamine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with terazosin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "leflunomide", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with nimesulide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with duloxetine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with maprotiline.", "severity": 2}
{"drug1": "Micafungin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with diltiazem.", "severity": 2}
{"drug1": "Melatonin", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with carisoprodol.", "severity": 2}
{"drug1": "buspirone", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with bromocriptine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with quinapril.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with nimesulide.", "severity": 2}
{"drug1": "itraconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with eperisone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with difluprednate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ticlopidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ticlopidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Levetiracetam.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Deferasirox.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with sulpiride.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "sildenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with sildenafil.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "caffeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with caffeine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "azithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with azithromycin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Lormetazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "fosinopril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with niflumic acid.", "severity": 2}
{"drug1": "amifostine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Tolcapone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with donepezil.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with protriptyline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with tiapride.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Fluspirilene.", "severity": 2}
{"drug1": "betamethasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Demecarium.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with flunarizine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with eperisone.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Pentolinium.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with dantrolene.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Articaine.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with flunarizine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with triamcinolone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Articaine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with nalbuphine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Halazepam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Ketobemidone.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Tapentadol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with chlorpheniramine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with diflunisal.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Pizotifen.", "severity": 2}
{"drug1": "theophylline", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when theophylline is combined with pancuronium.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Pipamperone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with dantrolene.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Flibanserin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Varenicline.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Icatibant.", "severity": 2}
{"drug1": "etizolam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with vigabatrin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Articaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with estazolam.", "severity": 2}
{"drug1": "sulindac", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Perospirone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with dichlorphenamide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with chlormezanone.", "severity": 2}
{"drug1": "aspirin", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with DESONIDE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with chloral hydrate.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with MELPERONE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with fludiazepam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with desipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Levomilnacipran.", "severity": 2}
{"drug1": "secobarbital", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with HEROIN.", "severity": 2}
{"drug1": "levorphanol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with meclizine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Flupentixol.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with levodopa.", "severity": 2}
{"drug1": "methysergide", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Pazopanib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Vilanterol.", "severity": 2}
{"drug1": "proparacaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with fexofenadine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with flunisolide.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with pirenzepine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Tolcapone.", "severity": 2}
{"drug1": "phenazopyridine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenazopyridine is combined with prilocaine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Ziprasidone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with levorphanol.", "severity": 2}
{"drug1": "etizolam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with protriptyline.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Zucapsaicin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with zopiclone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Fulvestrant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Fulvestrant.", "severity": 2}
{"drug1": "cabergoline", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Micafungin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with xylometazoline.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with 3,4-Dihydroxybenzaldehyde.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with nifedipine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Oxetacaine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ILOPROST.", "severity": 2}
{"drug1": "triamterene", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with brimonidine.", "severity": 2}
{"drug1": "halothane", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Aliskiren.", "severity": 2}
{"drug1": "triamterene", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with sotalol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with halothane.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with spironolactone.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Mometasone.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with propofol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with chlormezanone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with selegiline.", "severity": 2}
{"drug1": "flurazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Ropivacaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Etomidate.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Escitalopram.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "promazine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Paliperidone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Almotriptan.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with mequitazine.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with atorvastatin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with Deferasirox.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with nalbuphine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tiapride", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Fencamfamin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with thalidomide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Canrenoic acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with dantrolene.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Remoxipride.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with DESONIDE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with methyldopa.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with dibucaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with metolazone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Indacaterol.", "severity": 2}
{"drug1": "procaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with fludiazepam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Abiraterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Abiraterone.", "severity": 2}
{"drug1": "losartan", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with thiamylal.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Pipamperone.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dabigatran etexilate is combined with Temsirolimus.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with procaine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with indomethacin.", "severity": 2}
{"drug1": "butalbital", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Iloperidone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfadiazine is combined with mecamylamine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with BISOPROLOL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with scopolamine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with midazolam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Agomelatine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with zaltoprofen.", "severity": 2}
{"drug1": "oxazepam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with zopiclone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Pipotiazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with sertraline.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amodiaquine is combined with mefloquine.", "severity": 2}
{"drug1": "azelastine", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with oxaprozin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Eprosartan.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Desloratadine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with lithium ion.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with amobarbital.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Pefloxacin.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with simvastatin.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with amisulpride.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with methylprednisolone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with HEROIN.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with etizolam.", "severity": 2}
{"drug1": "loxapine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with nitrazepam.", "severity": 2}
{"drug1": "dyclonine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with fludiazepam.", "severity": 2}
{"drug1": "Halazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with brotizolam.", "severity": 2}
{"drug1": "dyclonine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with chloral hydrate.", "severity": 2}
{"drug1": "milrinone", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with mesalamine.", "severity": 2}
{"drug1": "morphine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with MELPERONE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with leflunomide.", "severity": 2}
{"drug1": "procyclidine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with nalbuphine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with felodipine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Pipamperone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with pentazocine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with nefazodone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with BISOPROLOL.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Icatibant.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with topiramate.", "severity": 2}
{"drug1": "dibucaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with HEROIN.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with atorvastatin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with ethosuximide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with desipramine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nisoldipine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with decamethonium.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with losartan.", "severity": 2}
{"drug1": "propofol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Propoxycaine.", "severity": 2}
{"drug1": "nystatin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with gabapentin.", "severity": 2}
{"drug1": "Metixene", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with butorphanol.", "severity": 2}
{"drug1": "propofol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Pramocaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with thioridazine.", "severity": 2}
{"drug1": "propofol", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nitrazepam.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with quinapril.", "severity": 2}
{"drug1": "methazolamide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with isoxsuprine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Salsalate.", "severity": 2}
{"drug1": "halothane", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Bretylium.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with bumetanide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with oxymorphone.", "severity": 2}
{"drug1": "Butethal", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Butethal", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with flunitrazepam.", "severity": 2}
{"drug1": "vincristine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vincristine is combined with atorvastatin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Pizotifen.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with nalbuphine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with bumetanide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with chlorothiazide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with quinapril.", "severity": 2}
{"drug1": "apomorphine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with methyclothiazide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with rescinnamine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with captopril.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with minoxidil.", "severity": 2}
{"drug1": "glutethimide", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with MOLINDONE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Aceprometazine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with cilazapril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "amiodarone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with methyclothiazide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with potassium ion.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Perospirone.", "severity": 2}
{"drug1": "losartan", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Telmisartan.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "losartan", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with salicylamide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with scopolamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with cyclothiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with chlorprothixene.", "severity": 2}
{"drug1": "tolmetin", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with alclofenac.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with nadolol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with triamterene.", "severity": 2}
{"drug1": "sotalol", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with fosinopril.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with levodopa.", "severity": 2}
{"drug1": "butabarbital", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with trimipramine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "quazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with reserpine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with timolol.", "severity": 2}
{"drug1": "meperidine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with clonidine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Tolcapone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Teriflunomide.", "severity": 2}
{"drug1": "diazepam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with nitrazepam.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with trichlormethiazide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with cetirizine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Flibanserin.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with mycophenolic acid.", "severity": 2}
{"drug1": "brotizolam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with protriptyline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Eprosartan.", "severity": 2}
{"drug1": "clorazepate", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with sevoflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with levodopa.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with isradipine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with salicylamide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Estrone sulfate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with chlorprothixene.", "severity": 2}
{"drug1": "midazolam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with diphenhydramine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with cinnarizine.", "severity": 2}
{"drug1": "propranolol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with methyldopa.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Artemether", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with nimodipine.", "severity": 2}
{"drug1": "propranolol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with apraclonidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Telmisartan.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with formoterol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with procaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with trimipramine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with tretinoin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ethotoin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with prilocaine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with levorphanol.", "severity": 2}
{"drug1": "epirizole", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with alclofenac.", "severity": 2}
{"drug1": "triprolidine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "meclizine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Asenapine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with nifedipine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with butamben.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Ketobemidone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with dichlorphenamide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with oxycodone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Bretylium.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Risedronic acid.", "severity": 2}
{"drug1": "Icatibant", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with flurandrenolide.", "severity": 2}
{"drug1": "losartan", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with isoxsuprine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Torasemide.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with ethotoin.", "severity": 2}
{"drug1": "baclofen", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with ethosuximide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with NAPROXEN.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Desloratadine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Ropivacaine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with salicylamide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with imipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with loratadine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with droxidopa.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with clemastine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with fenbufen.", "severity": 2}
{"drug1": "atenolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with METAXALONE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with baclofen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with difluprednate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with benzyl alcohol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with ethchlorvynol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with butalbital.", "severity": 2}
{"drug1": "meclizine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with fexofenadine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Desloratadine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with perphenazine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "nicergoline", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with tacrolimus.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Palbociclib is combined with atorvastatin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with doxepin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with triazolam.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Lormetazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with nefazodone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with clemastine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with lidocaine.", "severity": 2}
{"drug1": "atenolol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with nadolol.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "midazolam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Cariprazine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with procaine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Telmisartan.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with sparfloxacin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Frovatriptan.", "severity": 2}
{"drug1": "temazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with procaine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with sulfanilamide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Etoricoxib.", "severity": 2}
{"drug1": "temazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with trimipramine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with dantrolene.", "severity": 2}
{"drug1": "epirizole", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "epirizole", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Halobetasol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "doxycycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with doxycycline.", "severity": 2}
{"drug1": "nicergoline", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with protriptyline.", "severity": 2}
{"drug1": "butabarbital", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with nitrous oxide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with glutethimide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with halcinonide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with cetirizine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "ketamine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with butalbital.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "morphine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with felbamate.", "severity": 2}
{"drug1": "tolmetin", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with alclometasone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Pipamperone.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with vigabatrin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with MELPERONE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with mecamylamine.", "severity": 2}
{"drug1": "codeine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with lidocaine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Canagliflozin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "methadone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with prilocaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with baclofen.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with formestane.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with bumetanide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with quinapril.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with chlorothiazide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with duloxetine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with nilvadipine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with meclizine.", "severity": 2}
{"drug1": "meperidine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with GUANFACINE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with clonidine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with prazepam.", "severity": 2}
{"drug1": "loxapine", "drug2": "lorazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with lorazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "codeine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with isoflurane.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "flutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with flutamide.", "severity": 2}
{"drug1": "codeine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ethotoin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with methadone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Apremilast", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with leflunomide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Mometasone.", "severity": 2}
{"drug1": "amifostine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with morphine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with etizolam.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BOPINDOLOL is combined with Varenicline.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with HEROIN.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "selegiline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with OLODATEROL.", "severity": 2}
{"drug1": "selegiline", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Vilanterol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with promethazine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with baclofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with hydralazine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Doxercalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with Doxercalciferol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Ketobemidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with tretinoin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ethotoin.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with meperidine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with prilocaine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Escitalopram.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with clenbuterol.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with protriptyline.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Cis-mdp.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with cetirizine.", "severity": 2}
{"drug1": "methadone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with benzocaine.", "severity": 2}
{"drug1": "methadone", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "clozapine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with butorphanol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with nisoldipine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with duloxetine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with fluoxetine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with celiprolol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with flunarizine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with indapamide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with timolol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with tetracaine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with naratriptan.", "severity": 2}
{"drug1": "thioguanine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioguanine is combined with leflunomide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with chloral hydrate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with clonazepam.", "severity": 2}
{"drug1": "buspirone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with levodopa.", "severity": 2}
{"drug1": "buspirone", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with sevoflurane.", "severity": 2}
{"drug1": "trazodone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Pipamperone.", "severity": 2}
{"drug1": "tetracycline", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracycline is combined with atorvastatin.", "severity": 2}
{"drug1": "buspirone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with metoclopramide.", "severity": 2}
{"drug1": "buspirone", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Lorcaserin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Salsalate.", "severity": 2}
{"drug1": "buspirone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Aripiprazole.", "severity": 2}
{"drug1": "buspirone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with chlorprothixene.", "severity": 2}
{"drug1": "thiopental", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with tiapride.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nilvadipine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with DESONIDE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with rizatriptan.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with duloxetine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with fexofenadine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with trimipramine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with pramipexole.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with carisoprodol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with pramipexole.", "severity": 2}
{"drug1": "ibudilast", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibudilast is combined with diflunisal.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Oxetacaine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamethoxazole is combined with prilocaine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with linezolid.", "severity": 2}
{"drug1": "Halazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with pimozide.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Iloperidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with MOLINDONE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Etomidate.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with bupivacaine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Ropivacaine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Nebivolol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Levetiracetam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with loxapine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Remoxipride.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with prednisone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with chloramphenicol.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with DEZOCINE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Tasimelteon.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Escitalopram.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "levodopa", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with isocarboxazid.", "severity": 2}
{"drug1": "midazolam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with promethazine.", "severity": 2}
{"drug1": "midazolam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with clonazepam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Oxetacaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Riociguat.", "severity": 2}
{"drug1": "Normethadone", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with clemastine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with procarbazine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with furazolidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Melatonin.", "severity": 2}
{"drug1": "biperiden", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Trospium.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "lidocaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with benzocaine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Clevidipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ciprofloxacin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Pizotifen.", "severity": 2}
{"drug1": "nicergoline", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with Nebivolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with isoxsuprine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with dibucaine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with maprotiline.", "severity": 2}
{"drug1": "gabapentin", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with benzocaine.", "severity": 2}
{"drug1": "eperisone", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with zotepine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with triamterene.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with HEROIN.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "morphine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Bretylium.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with NAPROXEN.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with procarbazine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with AMILORIDE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with hydralazine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with doxazosin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with nortriptyline.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with labetalol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with chloroquine.", "severity": 2}
{"drug1": "methysergide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Ifenprodil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Ifenprodil.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with metoclopramide.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with efavirenz.", "severity": 2}
{"drug1": "nimodipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with D-mannitol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with clomipramine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with tiapride.", "severity": 2}
{"drug1": "sildenafil", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sildenafil is combined with mecamylamine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with quetiapine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with KETAZOLAM.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Metipranolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with etizolam.", "severity": 2}
{"drug1": "tolterodine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with methscopolamine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with meclizine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Lumiracoxib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with dantrolene.", "severity": 2}
{"drug1": "ketamine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with MELPERONE.", "severity": 2}
{"drug1": "morphine", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with alprazolam.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Crizotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Crizotinib.", "severity": 2}
{"drug1": "tolmetin", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with mefenamic acid.", "severity": 2}
{"drug1": "enflurane", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with trimipramine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with digoxin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nimodipine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with epirizole.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Normethadone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with scopolamine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with NAPROXEN.", "severity": 2}
{"drug1": "bromazepam", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with quazepam.", "severity": 2}
{"drug1": "Articaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Ketobemidone.", "severity": 2}
{"drug1": "morphine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with reserpine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Paliperidone.", "severity": 2}
{"drug1": "codeine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with tizanidine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Milnacipran.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with testosterone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with lomustine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with mitoxantrone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Indacaterol.", "severity": 2}
{"drug1": "cilazapril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with ADAPALENE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Difenoxin.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gliclazide is combined with Carbocisteine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with vigabatrin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Sacubitril.", "severity": 2}
{"drug1": "azelastine", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with Rosuvastatin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Normethadone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with nifedipine.", "severity": 2}
{"drug1": "suprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with budesonide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with papaverine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "phentolamine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with D-mannitol.", "severity": 2}
{"drug1": "aspirin", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with lithium ion.", "severity": 2}
{"drug1": "thiothixene", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with ethotoin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with tranylcypromine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with prilocaine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with pargyline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with methocarbamol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with promazine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with PAMABROM.", "severity": 2}
{"drug1": "prazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with baclofen.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Pipotiazine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with trandolapril.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with carprofen.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with procarbazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Arformoterol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Clodronic Acid.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with thalidomide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Eribulin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Eribulin.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with atorvastatin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with captopril.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Etidocaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with acebutolol.", "severity": 2}
{"drug1": "Icatibant", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with hydrocortisone.", "severity": 2}
{"drug1": "ramipril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ZILEUTON.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Salbutamol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with alprazolam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with progesterone.", "severity": 2}
{"drug1": "pargyline", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with mirtazapine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with clomipramine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Eszopiclone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Cyamemazine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with flunitrazepam.", "severity": 2}
{"drug1": "procaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Olopatadine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Ruxolitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Ruxolitinib.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Remoxipride.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with loxapine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with glutethimide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aminophylline is combined with pancuronium.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with malathion.", "severity": 2}
{"drug1": "estazolam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Difenoxin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with triamterene.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with tubocurarine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with dipyridamole.", "severity": 2}
{"drug1": "furazolidone", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with droxidopa.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Idelalisib is combined with toremifene.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with clonidine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with oxycodone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with pilocarpine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Clofarabine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with SERTINDOLE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Halazepam.", "severity": 2}
{"drug1": "cocaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with alclofenac.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Pomalidomide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with acebutolol.", "severity": 2}
{"drug1": "propofol", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with gabapentin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with nalidixic acid.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with captopril.", "severity": 2}
{"drug1": "enalapril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with terazosin.", "severity": 2}
{"drug1": "propofol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with vigabatrin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with etoposide.", "severity": 2}
{"drug1": "procaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with butamben.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with carprofen.", "severity": 2}
{"drug1": "lorazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with trimipramine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with procaine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with pyridostigmine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with prazosin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with scopolamine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Ezetimibe.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Eprosartan.", "severity": 2}
{"drug1": "milrinone", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with Olsalazine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with clemastine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with selegiline.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with brotizolam.", "severity": 2}
{"drug1": "tolmetin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with leflunomide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with resveratrol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with protriptyline.", "severity": 2}
{"drug1": "lithium ion", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with cetirizine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Nebivolol.", "severity": 2}
{"drug1": "linezolid", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Perospirone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Imatinib is combined with leflunomide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "promazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with cyclothiazide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with equilin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Flibanserin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with loratadine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Etidronic acid.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Tixocortol.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with nicardipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with flurbiprofen.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Milnacipran.", "severity": 2}
{"drug1": "tizanidine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with glutethimide.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with tolfenamic acid.", "severity": 2}
{"drug1": "trazodone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with levodopa.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Ramelteon.", "severity": 2}
{"drug1": "Melatonin", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with chlorprothixene.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with phenytoin.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with fludrocortisone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with SERATRODAST.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with zafirlukast.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Aceclofenac.", "severity": 2}
{"drug1": "clozapine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Pipamperone.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PENTAERYTHRITOL TETRANITRATE is combined with rosiglitazone.", "severity": 2}
{"drug1": "bepridil", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Conivaptan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with SERTINDOLE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with HEROIN.", "severity": 2}
{"drug1": "meprobamate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "promazine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with mepivacaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with trifluoperazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with methoxyflurane.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Pomalidomide.", "severity": 2}
{"drug1": "methadone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Fencamfamin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with chlorthalidone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with desipramine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with pirenzepine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with amobarbital.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with felbamate.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Clevidipine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with Tianeptine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with cilazapril.", "severity": 2}
{"drug1": "spironolactone", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with sotalol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with losartan.", "severity": 2}
{"drug1": "zotepine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with scopolamine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with hydromorphone.", "severity": 2}
{"drug1": "butalbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with flurandrenolide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with NAPROXEN.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with prednisone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "sulindac", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "diclofenac", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with antipyrine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with indapamide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with amoxapine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with clozapine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with cinnarizine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "glimepiride", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glimepiride is combined with leflunomide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "prilocaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with tizanidine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Olopatadine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Olmesartan.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Pipamperone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "zotepine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with tizanidine.", "severity": 2}
{"drug1": "enalapril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with floctafenine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Clevidipine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Pipotiazine.", "severity": 2}
{"drug1": "cocaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with cilazapril.", "severity": 2}
{"drug1": "triazolam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Desloratadine.", "severity": 2}
{"drug1": "valsartan", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with mesalamine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with carprofen.", "severity": 2}
{"drug1": "clorazepate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Normethadone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Olopatadine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Butethal.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Fospropofol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with medrysone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with amobarbital.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Loxoprofen.", "severity": 2}
{"drug1": "miconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with manidipine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "miconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with methoxyflurane.", "severity": 2}
{"drug1": "miconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "butalbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with clidinium.", "severity": 2}
{"drug1": "miconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with fludiazepam.", "severity": 2}
{"drug1": "miconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with scopolamine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with memantine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with D-mannitol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "ethanol", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with pargyline.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RUCAPARIB is combined with atorvastatin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methotrexate is combined with clozapine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with desipramine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "prazosin", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with papaverine.", "severity": 2}
{"drug1": "prazosin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with nifedipine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with cetirizine.", "severity": 2}
{"drug1": "triazolam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with procaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with trimipramine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Atracurium besylate.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Fluspirilene.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with trichlormethiazide.", "severity": 2}
{"drug1": "clidinium", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with paroxetine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "amcinonide", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with malathion.", "severity": 2}
{"drug1": "spironolactone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with bumetanide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with scopolamine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Etomidate.", "severity": 2}
{"drug1": "isoflurane", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with bupivacaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Ropivacaine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Fluspirilene.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Lormetazepam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with amobarbital.", "severity": 2}
{"drug1": "pergolide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with haloperidol.", "severity": 2}
{"drug1": "pergolide", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with ritonavir.", "severity": 2}
{"drug1": "trandolapril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with indomethacin.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with quinidine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with efavirenz.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with isoxsuprine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with edrophonium.", "severity": 2}
{"drug1": "baclofen", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with levodopa.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with epirizole.", "severity": 2}
{"drug1": "doxylamine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with Escitalopram.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with mesoridazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with maprotiline.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Iloperidone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with trazodone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with CLONIXIN.", "severity": 2}
{"drug1": "loxapine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with thiopental.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Etomidate.", "severity": 2}
{"drug1": "Articaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with citalopram.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosamprenavir is combined with oxycodone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with desipramine.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with sevoflurane.", "severity": 2}
{"drug1": "triazolam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with levodopa.", "severity": 2}
{"drug1": "procaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with halothane.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with nylidrin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with DESONIDE.", "severity": 2}
{"drug1": "procaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with thiamylal.", "severity": 2}
{"drug1": "metolazone", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with carvedilol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Bretylium.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with scopolamine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with baclofen.", "severity": 2}
{"drug1": "cisplatin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cisplatin is combined with leflunomide.", "severity": 2}
{"drug1": "pramipexole", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with D-mannitol.", "severity": 2}
{"drug1": "triazolam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with etizolam.", "severity": 2}
{"drug1": "acemetacin", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Fluprednidene.", "severity": 2}
{"drug1": "propantheline", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with hyoscyamine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with methscopolamine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with tiapride.", "severity": 2}
{"drug1": "ketamine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with trazodone.", "severity": 2}
{"drug1": "risperidone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Paliperidone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with malathion.", "severity": 2}
{"drug1": "propofol", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ketamine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with nalidixic acid.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with clonazepam.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with promethazine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with terazosin.", "severity": 2}
{"drug1": "medrysone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with ambenonium.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Ethylmorphine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with doxepin.", "severity": 2}
{"drug1": "trazodone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with flunitrazepam.", "severity": 2}
{"drug1": "flumethasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with rivastigmine.", "severity": 2}
{"drug1": "isoniazid", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoniazid is combined with acetaminophen.", "severity": 2}
{"drug1": "clozapine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Propoxycaine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Pramocaine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with sertraline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with methyclothiazide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with flurandrenolide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Cyamemazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "penbutolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with floctafenine.", "severity": 2}
{"drug1": "valsartan", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with bumetanide.", "severity": 2}
{"drug1": "valsartan", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with chlorothiazide.", "severity": 2}
{"drug1": "valsartan", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with quinapril.", "severity": 2}
{"drug1": "valsartan", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with MELPERONE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "sertraline", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with loxapine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with nitrous oxide.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with trandolapril.", "severity": 2}
{"drug1": "haloperidol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with oxprenolol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with clidinium.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Retigabine.", "severity": 2}
{"drug1": "nystatin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with cinnarizine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with Ketobemidone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "moclobemide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "metolazone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with GUANFACINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Lornoxicam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with HEROIN.", "severity": 2}
{"drug1": "mesalamine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with alclometasone.", "severity": 2}
{"drug1": "indapamide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "quinapril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Olsalazine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with paroxetine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with zotepine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Pregabalin.", "severity": 2}
{"drug1": "bifonazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with nicardipine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Fencamfamin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Flupentixol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with thiamylal.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with clidinium.", "severity": 2}
{"drug1": "morphine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with brotizolam.", "severity": 2}
{"drug1": "propofol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with triamterene.", "severity": 2}
{"drug1": "ketorolac", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with tetracaine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with mirtazapine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with triprolidine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with tetracaine.", "severity": 2}
{"drug1": "morphine", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with methocarbamol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with nalidixic acid.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Tolcapone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with nifedipine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with desipramine.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with zaltoprofen.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Aceclofenac.", "severity": 2}
{"drug1": "Halazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with zotepine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with isoxsuprine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with fexofenadine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with SERATRODAST.", "severity": 2}
{"drug1": "midazolam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Iloperidone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with spironolactone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Agomelatine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with isoproterenol.", "severity": 2}
{"drug1": "equilin", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with nalidixic acid.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Dabigatran etexilate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with quetiapine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with olanzapine.", "severity": 2}
{"drug1": "equilin", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with malathion.", "severity": 2}
{"drug1": "quetiapine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with benzocaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with promethazine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with clonazepam.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Perospirone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Melatonin.", "severity": 2}
{"drug1": "isradipine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with fosinopril.", "severity": 2}
{"drug1": "protriptyline", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with clomipramine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Levetiracetam.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with donepezil.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nilvadipine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with nimesulide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with GUANFACINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Pramocaine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with manidipine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Lacidipine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Efonidipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with bezafibrate.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with lisinopril.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Pimecrolimus.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Benidipine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with nisoldipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Tasimelteon.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with rizatriptan.", "severity": 2}
{"drug1": "meperidine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with dantrolene.", "severity": 2}
{"drug1": "Apremilast", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "meperidine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with estazolam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with clotiazepam.", "severity": 2}
{"drug1": "Isometheptene", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isometheptene is combined with NITROUS ACID.", "severity": 2}
{"drug1": "zopiclone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with amobarbital.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Butethal.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Hexobarbital.", "severity": 2}
{"drug1": "zopiclone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with lithium ion.", "severity": 2}
{"drug1": "difluprednate", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with metoclopramide.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with efavirenz.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Tramadol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with methoxyflurane.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with venlafaxine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with chloral hydrate.", "severity": 2}
{"drug1": "losartan", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "triamterene", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with carvedilol.", "severity": 2}
{"drug1": "methadone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with butamben.", "severity": 2}
{"drug1": "gabapentin", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with baclofen.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with felbamate.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with norfloxacin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Echothiophate.", "severity": 2}
{"drug1": "gabapentin", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with ethchlorvynol.", "severity": 2}
{"drug1": "losartan", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with nimesulide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Butethal.", "severity": 2}
{"drug1": "rasagiline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with OLODATEROL.", "severity": 2}
{"drug1": "morphine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "pimozide", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Melatonin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with SERTINDOLE.", "severity": 2}
{"drug1": "pimozide", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with clonazepam.", "severity": 2}
{"drug1": "acemetacin", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with prednisone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Vilanterol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with chlorprothixene.", "severity": 2}
{"drug1": "phenindione", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenindione is combined with Nintedanib.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Ramelteon.", "severity": 2}
{"drug1": "thiamylal", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with flunitrazepam.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with clonazepam.", "severity": 2}
{"drug1": "cetirizine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with promethazine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with dobutamine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with loteprednol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with tiapride.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with thiopental.", "severity": 2}
{"drug1": "estazolam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Pizotifen.", "severity": 2}
{"drug1": "amisulpride", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with baclofen.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with clemastine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Droxicam.", "severity": 2}
{"drug1": "polythiazide", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with nitric oxide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Paliperidone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with tolfenamic acid.", "severity": 2}
{"drug1": "amifostine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Etidocaine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with propoxyphene.", "severity": 2}
{"drug1": "morphine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with GUANFACINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with dyclonine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Milnacipran.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Salbutamol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "temazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nicergoline", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with tioconazole.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Loxoprofen.", "severity": 2}
{"drug1": "meprobamate", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with efavirenz.", "severity": 2}
{"drug1": "triazolam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with glutethimide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with zotepine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with MELPERONE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Etidocaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Potassium citrate.", "severity": 2}
{"drug1": "quazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with clonidine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with captopril.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Ketobemidone.", "severity": 2}
{"drug1": "L-tryptophan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when L-tryptophan is combined with procarbazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Tolvaptan.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Riociguat.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Asenapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with atorvastatin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with phenytoin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with timolol.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfanilamide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "isradipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with fenoprofen.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "butamben", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with clomipramine.", "severity": 2}
{"drug1": "enflurane", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Nabilone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with MELPERONE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with enalapril.", "severity": 2}
{"drug1": "epirizole", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with dexamethasone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with formestane.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Fencamfamin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with ESMOLOL.", "severity": 2}
{"drug1": "codeine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with rasagiline.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with tolazoline.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Efonidipine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with scopolamine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with cilazapril.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with quinapril.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Propoxycaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Fencamfamin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with bumetanide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with mefloquine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with chlorzoxazone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with diflunisal.", "severity": 2}
{"drug1": "nicergoline", "drug2": "methylergonovine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with methylergonovine.", "severity": 2}
{"drug1": "topiramate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Pipotiazine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with butalbital.", "severity": 2}
{"drug1": "tretinoin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with benazepril.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with fenbufen.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Levocetirizine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with ethotoin.", "severity": 2}
{"drug1": "tiagabine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Desloratadine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with mepivacaine.", "severity": 2}
{"drug1": "triamterene", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with hydralazine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Pramocaine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with paroxetine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with vigabatrin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with lansoprazole.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with amitriptyline.", "severity": 2}
{"drug1": "Propiverine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Clodronic Acid.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with dipyridamole.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with tizanidine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with DESONIDE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with betamethasone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with loratadine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with chloramphenicol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with dipyridamole.", "severity": 2}
{"drug1": "isradipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with nortriptyline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with amoxapine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Difenoxin.", "severity": 2}
{"drug1": "isradipine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with labetalol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with enflurane.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with chlorprothixene.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Ciclesonide.", "severity": 2}
{"drug1": "halothane", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with tiapride.", "severity": 2}
{"drug1": "milrinone", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Cariprazine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with budesonide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with levodopa.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "bumetanide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with digitoxin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with D-mannitol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ZILEUTON.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with etodolac.", "severity": 2}
{"drug1": "butorphanol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with baclofen.", "severity": 2}
{"drug1": "thiothixene", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with fexofenadine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with fluocinonide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Riociguat.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "midodrine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with zopiclone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Aceprometazine.", "severity": 2}
{"drug1": "reserpine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with oxymorphone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Remoxipride.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Benidipine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Azelnidipine.", "severity": 2}
{"drug1": "benztropine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with gabapentin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with isoetharine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with oxprenolol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Lacidipine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with formestane.", "severity": 2}
{"drug1": "rapamycin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with manidipine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Dapagliflozin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with quazepam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with prazepam.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with butalbital.", "severity": 2}
{"drug1": "resveratrol", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with desoximetasone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Levobupivacaine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with butamben.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with duloxetine.", "severity": 2}
{"drug1": "promazine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with efavirenz.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Milnacipran.", "severity": 2}
{"drug1": "linezolid", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Iloperidone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with clidinium.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with ethotoin.", "severity": 2}
{"drug1": "promazine", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with clorazepate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with deslanoside.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "melphalan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with melphalan.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with captopril.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with pramipexole.", "severity": 2}
{"drug1": "cerulenin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with nimesulide.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with trichlormethiazide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with NICORANDIL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with levodopa.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with indapamide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Levetiracetam.", "severity": 2}
{"drug1": "enflurane", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Levocetirizine.", "severity": 2}
{"drug1": "midazolam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with DESFLURANE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Quinine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Quinine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with fexofenadine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Tasimelteon.", "severity": 2}
{"drug1": "clonidine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with methazolamide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Lacidipine.", "severity": 2}
{"drug1": "prazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with loratadine.", "severity": 2}
{"drug1": "enalapril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with azelastine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with trichlormethiazide.", "severity": 2}
{"drug1": "loratadine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with indapamide.", "severity": 2}
{"drug1": "loratadine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with flunarizine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with clonazepam.", "severity": 2}
{"drug1": "trazodone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with furazolidone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with losartan.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamethoxazole is combined with mecamylamine.", "severity": 2}
{"drug1": "diazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Ziprasidone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Paliperidone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with indapamide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Milnacipran.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with reserpine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with cetirizine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Clevidipine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Iloperidone.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Riociguat.", "severity": 2}
{"drug1": "buspirone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with nifedipine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Pipamperone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with papaverine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Lercanidipine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Lornoxicam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with fludiazepam.", "severity": 2}
{"drug1": "quinapril", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with nifedipine.", "severity": 2}
{"drug1": "quinapril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with papaverine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Lurasidone.", "severity": 2}
{"drug1": "meperidine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with midazolam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Nepafenac.", "severity": 2}
{"drug1": "quetiapine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with etizolam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Phenelzine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Pomalidomide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Perospirone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with acemetacin.", "severity": 2}
{"drug1": "enalapril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with epirizole.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with amitriptyline.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Tolcapone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with tiagabine.", "severity": 2}
{"drug1": "carprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with ondansetron.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "methysergide", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Quinupristin.", "severity": 2}
{"drug1": "enflurane", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with lithium ion.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Vilanterol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with amisulpride.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Fospropofol.", "severity": 2}
{"drug1": "enflurane", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Butethal.", "severity": 2}
{"drug1": "triazolam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with nitroglycerin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with lisinopril.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with procaine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Udenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tadalafil is combined with Udenafil.", "severity": 2}
{"drug1": "antipyrine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with clonazepam.", "severity": 2}
{"drug1": "barnidipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with D-mannitol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with meclizine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with manidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nitrendipine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with clonidine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with nitrazepam.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Benidipine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with levorphanol.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with methyclothiazide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with oxaprozin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Aripiprazole.", "severity": 2}
{"drug1": "midazolam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with chlorprothixene.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with felodipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "alprostadil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sildenafil is combined with alprostadil.", "severity": 2}
{"drug1": "efavirenz", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with meclizine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with irbesartan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with levodopa.", "severity": 2}
{"drug1": "furazolidone", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with domperidone.", "severity": 2}
{"drug1": "propofol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with methazolamide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Pazopanib.", "severity": 2}
{"drug1": "tiapride", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with METAXALONE.", "severity": 2}
{"drug1": "estrone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with bepridil.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with sotalol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Levocetirizine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with meclofenamic acid.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with tubocurarine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Hexobarbital.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Nabilone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Butethal.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with amobarbital.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ciprofloxacin.", "severity": 2}
{"drug1": "atenolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "suprofen", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with cinoxacin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with salicylic acid.", "severity": 2}
{"drug1": "minoxidil", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with triamterene.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "milrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with milrinone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Pomalidomide.", "severity": 2}
{"drug1": "codeine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with tiapride.", "severity": 2}
{"drug1": "losartan", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with dichlorphenamide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with triprolidine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "mechlorethamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with mechlorethamine.", "severity": 2}
{"drug1": "buspirone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with dibucaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Ciclesonide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with penbutolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Sacubitril.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with fludrocortisone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Torasemide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Flibanserin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Aceclofenac.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with mefloquine.", "severity": 2}
{"drug1": "loxapine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with tetracaine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with morphine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with sulpiride.", "severity": 2}
{"drug1": "mesalamine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with homoharringtonine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with leflunomide.", "severity": 2}
{"drug1": "midodrine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with isoxsuprine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Paliperidone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with floctafenine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with carisoprodol.", "severity": 2}
{"drug1": "pramipexole", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with enalapril.", "severity": 2}
{"drug1": "protriptyline", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "biperiden", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Pentolinium.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Pipamperone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with proparacaine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with flunitrazepam.", "severity": 2}
{"drug1": "isradipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with fluoxetine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with duloxetine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with citalopram.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with danazol.", "severity": 2}
{"drug1": "amifostine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with DESFLURANE.", "severity": 2}
{"drug1": "zotepine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Pizotifen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Lumiracoxib.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with nadolol.", "severity": 2}
{"drug1": "promethazine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with sertraline.", "severity": 2}
{"drug1": "procaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with ethosuximide.", "severity": 2}
{"drug1": "trazodone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Pramocaine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with terbutaline.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Cariprazine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tiapride", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Levetiracetam.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Empagliflozin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Empagliflozin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with prazosin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with diflorasone.", "severity": 2}
{"drug1": "azelastine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with fludiazepam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Propacetamol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with cilazapril.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nadolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Retigabine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with METAXALONE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with doxepin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with amoxapine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with nortriptyline.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with phenytoin.", "severity": 2}
{"drug1": "vindesine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vindesine is combined with leflunomide.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with nefazodone.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with propofol.", "severity": 2}
{"drug1": "pancuronium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "equilin", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with tubocurarine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with amitriptyline.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Tolcapone.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with sulindac.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Halobetasol.", "severity": 2}
{"drug1": "loxapine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with cocaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with ondansetron.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with levodopa.", "severity": 2}
{"drug1": "loxapine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with zonisamide.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with chloroquine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Fluspirilene.", "severity": 2}
{"drug1": "trazodone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with moclobemide.", "severity": 2}
{"drug1": "trazodone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Perospirone.", "severity": 2}
{"drug1": "trazodone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with chlormezanone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "5-Fluorocytosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with 5-Fluorocytosine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Pipamperone.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with rasagiline.", "severity": 2}
{"drug1": "ketamine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with dibucaine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with cinnarizine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with minoxidil.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Desloratadine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Telmisartan.", "severity": 2}
{"drug1": "Diatrizoic acid", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Diatrizoic acid is combined with metformin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with apraclonidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with floctafenine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with zaleplon.", "severity": 2}
{"drug1": "irinotecan", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irinotecan is combined with leflunomide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with clomipramine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with isocarboxazid.", "severity": 2}
{"drug1": "sertraline", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with trimipramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with methyldopa.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Torasemide.", "severity": 2}
{"drug1": "promazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with fluocinonide.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with nilvadipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with terazosin.", "severity": 2}
{"drug1": "propofol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with doxepin.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Temsirolimus is combined with leflunomide.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Acitretin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with Acitretin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with clidinium.", "severity": 2}
{"drug1": "medrysone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with pyridostigmine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with atenolol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Desloratadine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with olanzapine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with mepivacaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with efavirenz.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Risedronic acid.", "severity": 2}
{"drug1": "clonidine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Tasimelteon.", "severity": 2}
{"drug1": "carprofen", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "tizanidine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with felbamate.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with betaxolol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with thiopental.", "severity": 2}
{"drug1": "aspirin", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with prednisone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Aceclofenac.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with zaltoprofen.", "severity": 2}
{"drug1": "aspirin", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "thioridazine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with fludiazepam.", "severity": 2}
{"drug1": "carprofen", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Salsalate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with ethosuximide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with equilin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with felbamate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Butethal.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Olopatadine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Eplerenone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with methazolamide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Levetiracetam.", "severity": 2}
{"drug1": "diltiazem", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with D-mannitol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with dantrolene.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Gatifloxacin.", "severity": 2}
{"drug1": "butamben", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with ethotoin.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Zoledronic acid.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Risedronic acid.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Empagliflozin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with triprolidine.", "severity": 2}
{"drug1": "morphine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with diazepam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with methocarbamol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with methylphenidate.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with gabapentin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with estrone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with triazolam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with methoxyflurane.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with enoxacin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with nortriptyline.", "severity": 2}
{"drug1": "chloroquine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "olanzapine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with amoxapine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with amcinonide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "procaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with levorphanol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with meperidine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Paliperidone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with dobutamine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Pizotifen.", "severity": 2}
{"drug1": "bifonazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with barnidipine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with butalbital.", "severity": 2}
{"drug1": "phentolamine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Imatinib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Imatinib is combined with clozapine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with tiapride.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Flibanserin.", "severity": 2}
{"drug1": "valsartan", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with D-mannitol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with Ketobemidone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with nitrendipine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with dantrolene.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with cilazapril.", "severity": 2}
{"drug1": "dyclonine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with ethosuximide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ACENOCOUMAROL is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "methoxamine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with nicotine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Cevimeline.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Clevidipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Efonidipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Lacidipine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Iloperidone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Droxicam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with triamterene.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with trifluoperazine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Metipranolol.", "severity": 2}
{"drug1": "codeine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with fludiazepam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Droxicam.", "severity": 2}
{"drug1": "valsartan", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with terazosin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with nimesulide.", "severity": 2}
{"drug1": "codeine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chloral hydrate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Loxoprofen.", "severity": 2}
{"drug1": "triprolidine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with CLONIXIN.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "procarbazine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with OLODATEROL.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Vilanterol.", "severity": 2}
{"drug1": "sulindac", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with ethchlorvynol.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with oxyphenonium.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with baclofen.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Perospirone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with fenbufen.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Amrinone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with isocarboxazid.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with mecamylamine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Flibanserin.", "severity": 2}
{"drug1": "morphine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Pipamperone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with clomipramine.", "severity": 2}
{"drug1": "pergolide", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with oxybutynin.", "severity": 2}
{"drug1": "promethazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Thioproperazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with zotepine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Torasemide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with efavirenz.", "severity": 2}
{"drug1": "Torasemide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with bumetanide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with chlorothiazide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with quinapril.", "severity": 2}
{"drug1": "butabarbital", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with butamben.", "severity": 2}
{"drug1": "midazolam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with duloxetine.", "severity": 2}
{"drug1": "pergolide", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with methadone.", "severity": 2}
{"drug1": "midazolam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with fluoxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Perospirone.", "severity": 2}
{"drug1": "pergolide", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with omeprazole.", "severity": 2}
{"drug1": "labetalol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with nitroglycerin.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Etoricoxib.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with reserpine.", "severity": 2}
{"drug1": "labetalol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with lisinopril.", "severity": 2}
{"drug1": "temazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with thiothixene.", "severity": 2}
{"drug1": "indapamide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with penbutolol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Vilanterol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with procaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with propoxyphene.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "procaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with zonisamide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Eplerenone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with methazolamide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with carisoprodol.", "severity": 2}
{"drug1": "procaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with tiagabine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with DESONIDE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with sulpiride.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with oxprenolol.", "severity": 2}
{"drug1": "Olaparib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olaparib is combined with atorvastatin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with acetylcholine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Retigabine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Aripiprazole.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with Milnacipran.", "severity": 2}
{"drug1": "clozapine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with atenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Quinupristin.", "severity": 2}
{"drug1": "citalopram", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with zolmitriptan.", "severity": 2}
{"drug1": "midazolam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Echothiophate.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with simvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with rasagiline.", "severity": 2}
{"drug1": "temazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with levodopa.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Pizotifen.", "severity": 2}
{"drug1": "Trospium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with oxycodone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with tubocurarine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with nicardipine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Desloratadine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with galanthamine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with clidinium.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with prilocaine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with risperidone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with resveratrol.", "severity": 2}
{"drug1": "morphine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with prilocaine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Normethadone.", "severity": 2}
{"drug1": "clozapine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with sotalol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with etizolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with isocarboxazid.", "severity": 2}
{"drug1": "captopril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with tenoxicam.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with bepridil.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Empagliflozin.", "severity": 2}
{"drug1": "buspirone", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with dextromethorphan.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with triamcinolone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with ethotoin.", "severity": 2}
{"drug1": "captopril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with nabumetone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "ropinirole", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with terazosin.", "severity": 2}
{"drug1": "captopril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with ketorolac.", "severity": 2}
{"drug1": "imipramine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Levocetirizine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when decamethonium is combined with Varenicline.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with ibuprofen.", "severity": 2}
{"drug1": "terconazole", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Pitavastatin.", "severity": 2}
{"drug1": "halothane", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Ethylmorphine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with hydrocortisone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with flunarizine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Empagliflozin.", "severity": 2}
{"drug1": "halothane", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Fencamfamin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with scopolamine.", "severity": 2}
{"drug1": "estazolam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "tioconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with nimesulide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with thiopental.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with fenbufen.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Clobetasone.", "severity": 2}
{"drug1": "dantrolene", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with citalopram.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with formoterol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with memantine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tolmetin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Pipamperone.", "severity": 2}
{"drug1": "epirizole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilanterol is combined with leflunomide.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyamphetamine is combined with selegiline.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Difenoxin.", "severity": 2}
{"drug1": "epirizole", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with CLONIXIN.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with oxyphenonium.", "severity": 2}
{"drug1": "propantheline", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with oxyphenonium.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with DESFLURANE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with amisulpride.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with memantine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Gatifloxacin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Flibanserin.", "severity": 2}
{"drug1": "sulconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with nifedipine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with zonisamide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with tiagabine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with cocaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with ondansetron.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Butylscopolamine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with topiramate.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with loratadine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with flunisolide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with donepezil.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with ADAPALENE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with norfloxacin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with imipramine.", "severity": 2}
{"drug1": "propofol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with meclizine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with methazolamide.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Desloratadine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with mesoridazine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with maprotiline.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Metipranolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with acetazolamide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with rasagiline.", "severity": 2}
{"drug1": "clorazepate", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with DESFLURANE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with butalbital.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with efavirenz.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with tiagabine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Mephobarbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nicardipine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with trimipramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with maprotiline.", "severity": 2}
{"drug1": "pentazocine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with diazepam.", "severity": 2}
{"drug1": "budesonide", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with fleroxacin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with penbutolol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with zonisamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with oxazepam.", "severity": 2}
{"drug1": "butenafine", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with xylometazoline.", "severity": 2}
{"drug1": "butamben", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Milnacipran.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Olopatadine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with baclofen.", "severity": 2}
{"drug1": "amiodarone", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with cilnidipine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Lacidipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with methyclothiazide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Efonidipine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with desipramine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "carboplatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with carboplatin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with dibucaine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with leflunomide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with chlormezanone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with papaverine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with domperidone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with phenobarbital.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Escitalopram.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with lidocaine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Milnacipran.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Clobetasone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "benazepril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with celecoxib.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Flibanserin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with enalapril.", "severity": 2}
{"drug1": "ketorolac", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with sulfasalazine.", "severity": 2}
{"drug1": "benztropine", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with dicyclomine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Agomelatine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with PENTAERYTHRITOL TETRANITRATE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with chlorprothixene.", "severity": 2}
{"drug1": "diltiazem", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with chlorothiazide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with bumetanide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Tolcapone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with amitriptyline.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with pirenzepine.", "severity": 2}
{"drug1": "etodolac", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with flunisolide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with DEZOCINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with theobromine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "midazolam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with glutethimide.", "severity": 2}
{"drug1": "prazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with paroxetine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with alclofenac.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with zopiclone.", "severity": 2}
{"drug1": "loratadine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with tizanidine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with salicylamide.", "severity": 2}
{"drug1": "Fludarabine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fludarabine is combined with clozapine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with suprofen.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with loteprednol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Etidocaine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "linezolid", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Asenapine.", "severity": 2}
{"drug1": "desipramine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with citalopram.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with clemastine.", "severity": 2}
{"drug1": "temazepam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with pimozide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with venlafaxine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with mirtazapine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with meprobamate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Retigabine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with tizanidine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with fluvoxamine.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prostaglandin E2 is combined with Carbetocin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with lovastatin.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with nefazodone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Clobetasone.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with doxepin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with enflurane.", "severity": 2}
{"drug1": "brotizolam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with tetracaine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Frovatriptan.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with trichlormethiazide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with felodipine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with ethotoin.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Naftifine.", "severity": 2}
{"drug1": "meperidine", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with trichlormethiazide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with irbesartan.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with promazine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with isradipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with zopiclone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with cetirizine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with protriptyline.", "severity": 2}
{"drug1": "amifostine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with barnidipine.", "severity": 2}
{"drug1": "butalbital", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Levocetirizine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with Echothiophate.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Mirabegron.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Radium-223 chloride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Radium-223 chloride.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with methylprednisolone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with thiopental.", "severity": 2}
{"drug1": "thioridazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with etizolam.", "severity": 2}
{"drug1": "morphine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with trazodone.", "severity": 2}
{"drug1": "morphine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with pentazocine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with ethosuximide.", "severity": 2}
{"drug1": "butamben", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with amitriptyline.", "severity": 2}
{"drug1": "butamben", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Tolcapone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Rotigotine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with MELPERONE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with butamben.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with mycophenolic acid.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with homoharringtonine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with hydrocortisone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when decamethonium is combined with methacholine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with quetiapine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with chlorpheniramine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Difenoxin.", "severity": 2}
{"drug1": "cetirizine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with trimipramine.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcifediol is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "amikacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with amikacin.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with mepivacaine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with loxapine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ramipril.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with SERTINDOLE.", "severity": 2}
{"drug1": "dobutamine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with valsartan.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with rosiglitazone.", "severity": 2}
{"drug1": "prazosin", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with indapamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with resveratrol.", "severity": 2}
{"drug1": "captopril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Temsirolimus.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Fluspirilene.", "severity": 2}
{"drug1": "clorazepate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with flunarizine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Dapagliflozin.", "severity": 2}
{"drug1": "selegiline", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with furosemide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with medrysone.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Normethadone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Icatibant.", "severity": 2}
{"drug1": "Normethadone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with tiapride.", "severity": 2}
{"drug1": "amoxapine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with clidinium.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with acetazolamide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with BISOPROLOL.", "severity": 2}
{"drug1": "quazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with dantrolene.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with Ephedrine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with PROCATEROL.", "severity": 2}
{"drug1": "suprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "budesonide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Pentolinium.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Tixocortol.", "severity": 2}
{"drug1": "budesonide", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with Pefloxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Mometasone.", "severity": 2}
{"drug1": "biperiden", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Tapentadol.", "severity": 2}
{"drug1": "benazepril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with glutethimide.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with oxymorphone.", "severity": 2}
{"drug1": "argatroban", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with mesalamine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with quetiapine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with primidone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "alprostadil", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprostadil is combined with Apixaban.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with tolazoline.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with procarbazine.", "severity": 2}
{"drug1": "reserpine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with GUANFACINE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Tixocortol.", "severity": 2}
{"drug1": "pimozide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Desloratadine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with isocarboxazid.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Normethadone.", "severity": 2}
{"drug1": "pimozide", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with mepivacaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with butalbital.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with cinoxacin.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with clemastine.", "severity": 2}
{"drug1": "morphine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with amisulpride.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Capsaicin.", "severity": 2}
{"drug1": "Propiverine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with HEROIN.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Sitaxsentan.", "severity": 2}
{"drug1": "atenolol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with acebutolol.", "severity": 2}
{"drug1": "quazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with trimipramine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "atenolol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with captopril.", "severity": 2}
{"drug1": "cocaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with HEROIN.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with enoxacin.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with donepezil.", "severity": 2}
{"drug1": "bupropion", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupropion is combined with citalopram.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with METAXALONE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with estrone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Drospirenone.", "severity": 2}
{"drug1": "methadone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with nitrous oxide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with methocarbamol.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with triprolidine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Lormetazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with ethosuximide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Perospirone.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Pipamperone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with minoxidil.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Agomelatine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with ritodrine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with droperidol.", "severity": 2}
{"drug1": "morphine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Panobinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Panobinostat.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with meclizine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Cis-mdp.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with HYDROCODONE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with clemastine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with lidocaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Ketobemidone.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with carisoprodol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Atomoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Atomoxetine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Pipamperone.", "severity": 2}
{"drug1": "biperiden", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "trazodone", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Frovatriptan.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Flibanserin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with Cevimeline.", "severity": 2}
{"drug1": "thalidomide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with mecamylamine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "imipramine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nifedipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with atorvastatin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with ondansetron.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with tiagabine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with zonisamide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Tixocortol.", "severity": 2}
{"drug1": "methadone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with brotizolam.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "methadone", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Canrenoic acid.", "severity": 2}
{"drug1": "butalbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "methysergide", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with tranylcypromine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Vilanterol.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "methysergide", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with tetracycline.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Remoxipride.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with OLODATEROL.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with penbutolol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with topiramate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Hexobarbital.", "severity": 2}
{"drug1": "thalidomide", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with triamterene.", "severity": 2}
{"drug1": "pimozide", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with tetracaine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Lormetazepam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Canagliflozin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with barnidipine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with methyclothiazide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with diflorasone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with desipramine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with atenolol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with nitrazepam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with oxymetholone.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with isoxsuprine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "warfarin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with warfarin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "pentosan polysulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with pentosan polysulfate.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "aspirin", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "sulindac", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Fluprednidene.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with scopolamine.", "severity": 2}
{"drug1": "aspirin", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with amcinonide.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Telmisartan.", "severity": 2}
{"drug1": "ethotoin", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with dantrolene.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Potassium citrate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Lurasidone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Cyamemazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with trifluoperazine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with enalapril.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Halobetasol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Remoxipride.", "severity": 2}
{"drug1": "olanzapine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with triamterene.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with duloxetine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with desoximetasone.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with fluoxetine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "flunarizine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with triazolam.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with clomipramine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with nisoldipine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Empagliflozin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with Echothiophate.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with nortriptyline.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with amoxapine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Flibanserin.", "severity": 2}
{"drug1": "hydralazine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with rapamycin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Lormetazepam.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with nylidrin.", "severity": 2}
{"drug1": "Micafungin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with clomipramine.", "severity": 2}
{"drug1": "NALDEMEDINE", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NALDEMEDINE is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with citalopram.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Pipotiazine.", "severity": 2}
{"drug1": "etizolam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with ethotoin.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with thiothixene.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Thioproperazine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with azelastine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "actinomycin D", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with actinomycin D.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Tixocortol.", "severity": 2}
{"drug1": "Butethal", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with carisoprodol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with lithium ion.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with flunarizine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Milnacipran.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Isoflurophate.", "severity": 2}
{"drug1": "loteprednol", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with galanthamine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with quinidine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with haloperidol.", "severity": 2}
{"drug1": "dapsone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with nalidixic acid.", "severity": 2}
{"drug1": "promethazine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with lithium ion.", "severity": 2}
{"drug1": "enalapril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with felodipine.", "severity": 2}
{"drug1": "citalopram", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with bromocriptine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with nitrous oxide.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with trimipramine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with droxidopa.", "severity": 2}
{"drug1": "naratriptan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with droperidol.", "severity": 2}
{"drug1": "midazolam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with gabapentin.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Asenapine.", "severity": 2}
{"drug1": "clonidine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with felodipine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Pipamperone.", "severity": 2}
{"drug1": "methadone", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with pimozide.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "sodium chloride", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sodium chloride is combined with Tolvaptan.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Pefloxacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with estrone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with diazepam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with methazolamide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with apraclonidine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "amprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with amprenavir.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Enasidenib.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with furosemide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with tizanidine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with penbutolol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Clodronic Acid.", "severity": 2}
{"drug1": "amifostine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with spironolactone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "codeine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with felbamate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Thioproperazine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with thiothixene.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Etidronic acid.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Pipotiazine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Etoricoxib.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Clevidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with MELPERONE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with edrophonium.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Etidocaine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with citalopram.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with METAXALONE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with estrone.", "severity": 2}
{"drug1": "propofol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Melatonin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with NICORANDIL.", "severity": 2}
{"drug1": "bepridil", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Clofarabine.", "severity": 2}
{"drug1": "bepridil", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "trazodone", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Lorcaserin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Clevidipine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with medrysone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Pramocaine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with thiamylal.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with promazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with halothane.", "severity": 2}
{"drug1": "dopamine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "estrone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Demecarium.", "severity": 2}
{"drug1": "thiothixene", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with methoxyflurane.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with lithium ion.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Escitalopram.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with MOLINDONE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with CYCLIZINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Aceprometazine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Articaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Escitalopram.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with clomipramine.", "severity": 2}
{"drug1": "ramipril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ADAPALENE.", "severity": 2}
{"drug1": "biperiden", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Normethadone.", "severity": 2}
{"drug1": "ramipril", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Torasemide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with tretinoin.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with Tramadol.", "severity": 2}
{"drug1": "imipramine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nortriptyline.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with isoflurane.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Clevidipine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with duloxetine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Etidocaine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with fluoxetine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Octreotide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Octreotide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with dyclonine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with propoxyphene.", "severity": 2}
{"drug1": "equilin", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with edrophonium.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with epirizole.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "morphine", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Mersalyl.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with theobromine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Bretylium.", "severity": 2}
{"drug1": "protriptyline", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with procarbazine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with ethotoin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with minoxidil.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Agomelatine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "docetaxel", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with cabergoline.", "severity": 2}
{"drug1": "imipramine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Levalbuterol.", "severity": 2}
{"drug1": "equilin", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Demecarium.", "severity": 2}
{"drug1": "haloperidol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "leflunomide", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with flunisolide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Cladribine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Cladribine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with dantrolene.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with D-mannitol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with nifedipine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Lurasidone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with sotalol.", "severity": 2}
{"drug1": "risperidone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with thiamylal.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Propoxycaine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with penbutolol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Alvimopan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with procarbazine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Levocetirizine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with thiopental.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with papaverine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Nebivolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with nifedipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with levorphanol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with ethosuximide.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with xylometazoline.", "severity": 2}
{"drug1": "butorphanol", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with perphenazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with fludiazepam.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with tiagabine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with memantine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with azelastine.", "severity": 2}
{"drug1": "mestranol", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mestranol is combined with Ospemifene.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with zonisamide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with hydralazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "sulindac", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ethanol", "drug2": "CYSTEAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with CYSTEAMINE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with droperidol.", "severity": 2}
{"drug1": "ramipril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with apraclonidine.", "severity": 2}
{"drug1": "ramipril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with methyldopa.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with GUANFACINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with enflurane.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with homoharringtonine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with protriptyline.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Olopatadine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with mecamylamine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "cocaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with MELPERONE.", "severity": 2}
{"drug1": "cocaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with zotepine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Halazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Fluspirilene.", "severity": 2}
{"drug1": "butabarbital", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with flunarizine.", "severity": 2}
{"drug1": "argatroban", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "perphenazine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with sevoflurane.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Butylscopolamine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with nitrendipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with fosinopril.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with clonidine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with isoproterenol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bevantolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Aceprometazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with thiothixene.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Ciclesonide.", "severity": 2}
{"drug1": "meperidine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Pentolinium.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with cilazapril.", "severity": 2}
{"drug1": "meperidine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "timolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Cevimeline.", "severity": 2}
{"drug1": "timolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with nicotine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nisoldipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with quetiapine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Cyamemazine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Metixene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with meclizine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with memantine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with niflumic acid.", "severity": 2}
{"drug1": "meclizine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with levodopa.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Pizotifen.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "enflurane", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with fexofenadine.", "severity": 2}
{"drug1": "halothane", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with dipyridamole.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Milnacipran.", "severity": 2}
{"drug1": "sulindac", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with flunisolide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Bretylium.", "severity": 2}
{"drug1": "triprolidine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with clonazepam.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Salbutamol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with alclometasone.", "severity": 2}
{"drug1": "risperidone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with acetazolamide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with propofol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with brotizolam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with haloperidol.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Olopatadine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with etodolac.", "severity": 2}
{"drug1": "floctafenine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with hydrocortisone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with ZILEUTON.", "severity": 2}
{"drug1": "etodolac", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Propacetamol.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with nimesulide.", "severity": 2}
{"drug1": "clozapine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with captopril.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with betamethasone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with maprotiline.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with tetracaine.", "severity": 2}
{"drug1": "valsartan", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with doxazosin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Oxetacaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with brotizolam.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with amisulpride.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with salicylamide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with prednisone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with budesonide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with terazosin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EDOXABAN is combined with Deferasirox.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Cyamemazine.", "severity": 2}
{"drug1": "codeine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with halothane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Agomelatine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Naloxegol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with PAMABROM.", "severity": 2}
{"drug1": "loxapine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Agomelatine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with VERAPAMIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with prazosin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with thiothixene.", "severity": 2}
{"drug1": "selegiline", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with droperidol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with citalopram.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with indapamide.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Riociguat.", "severity": 2}
{"drug1": "maprotiline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with periciazine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Fesoterodine.", "severity": 2}
{"drug1": "loxapine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with lidocaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with clemastine.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with atorvastatin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with acemetacin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Teriflunomide.", "severity": 2}
{"drug1": "midazolam", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with oxazepam.", "severity": 2}
{"drug1": "tizanidine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with papaverine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Articaine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with amcinonide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "levodopa", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "midazolam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Mephobarbital.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Loxoprofen.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with efavirenz.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with furosemide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with tizanidine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with amoxapine.", "severity": 2}
{"drug1": "bepridil", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with droxidopa.", "severity": 2}
{"drug1": "loxapine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with isoflurane.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with nortriptyline.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with buprenorphine.", "severity": 2}
{"drug1": "loxapine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with ethotoin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with carisoprodol.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with isoxsuprine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with sulpiride.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "thioridazine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with minoxidil.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with primidone.", "severity": 2}
{"drug1": "temazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with ergocalciferol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Apremilast.", "severity": 2}
{"drug1": "betaxolol", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with acebutolol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with haloperidol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with captopril.", "severity": 2}
{"drug1": "nabumetone", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with sulfasalazine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "clozapine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with furosemide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with pentazocine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Lumiracoxib.", "severity": 2}
{"drug1": "lithium ion", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with fexofenadine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "propafenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with propafenone.", "severity": 2}
{"drug1": "methadone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with sotalol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Trovafloxacin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Pitavastatin.", "severity": 2}
{"drug1": "terbutaline", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Aliskiren.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Pomalidomide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with propofol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "nystatin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with isradipine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with tizanidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with clonidine.", "severity": 2}
{"drug1": "meperidine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "ramipril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with meclofenamic acid.", "severity": 2}
{"drug1": "Salsalate", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "diazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with theobromine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Mometasone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with ibuprofen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with DESFLURANE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with protriptyline.", "severity": 2}
{"drug1": "benazepril", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with lisinopril.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with cetirizine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with selegiline.", "severity": 2}
{"drug1": "ketorolac", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with DESONIDE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with citalopram.", "severity": 2}
{"drug1": "captopril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with diclofenac.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Frovatriptan.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with butalbital.", "severity": 2}
{"drug1": "nifedipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with hydralazine.", "severity": 2}
{"drug1": "triazolam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with cetirizine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with etizolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with protriptyline.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Empagliflozin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with SERATRODAST.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with timolol.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Levocetirizine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with benzocaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with butorphanol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextroamphetamine is combined with procarbazine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with furosemide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with tizanidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with trimipramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with fosinopril.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with baclofen.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with norfloxacin.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with nicardipine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with MOLINDONE.", "severity": 2}
{"drug1": "halothane", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with MOLINDONE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with aspirin.", "severity": 2}
{"drug1": "halothane", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Aceprometazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with ethchlorvynol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with methazolamide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with fludiazepam.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with Echothiophate.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Cyamemazine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Flibanserin.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Ethylmorphine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "ketamine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with felbamate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Etomidate.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with antipyrine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "estazolam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with clonidine.", "severity": 2}
{"drug1": "etodolac", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "sulconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with trimipramine.", "severity": 2}
{"drug1": "etodolac", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with flumethasone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with Calcifediol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with methacholine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Pomalidomide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Nilotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Nilotinib.", "severity": 2}
{"drug1": "meperidine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with scopolamine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with homoharringtonine.", "severity": 2}
{"drug1": "isradipine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with atenolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cisapride", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cisapride is combined with sulpiride.", "severity": 2}
{"drug1": "ramipril", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with captopril.", "severity": 2}
{"drug1": "olanzapine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with risperidone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with gabapentin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with clomipramine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with oxybutynin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Phenelzine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Crizotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Crizotinib.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with isoxsuprine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atomoxetine is combined with oxycodone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Deferasirox.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Lapatinib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with fludrocortisone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with risperidone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with meclizine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with efavirenz.", "severity": 2}
{"drug1": "acebutolol", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with lithium ion.", "severity": 2}
{"drug1": "diazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with clenbuterol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with Bambuterol.", "severity": 2}
{"drug1": "enalapril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with pargyline.", "severity": 2}
{"drug1": "perphenazine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with nitrazepam.", "severity": 2}
{"drug1": "nabumetone", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with salicylamide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with felodipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "butamben", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with triprolidine.", "severity": 2}
{"drug1": "trazodone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with tiagabine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "thiopental", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with propoxyphene.", "severity": 2}
{"drug1": "thiopental", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with dyclonine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Articaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Levetiracetam.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with diflunisal.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with fludiazepam.", "severity": 2}
{"drug1": "thioridazine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with triazolam.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with sparfloxacin.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with sertraline.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with nefazodone.", "severity": 2}
{"drug1": "meperidine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with methyclothiazide.", "severity": 2}
{"drug1": "enalapril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Olopatadine.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with chlorthalidone.", "severity": 2}
{"drug1": "furosemide", "drug2": "netilmicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with netilmicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Mephobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with dibucaine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with nalbuphine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Agomelatine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with bepridil.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Pipamperone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with isoproterenol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with triamterene.", "severity": 2}
{"drug1": "meprobamate", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with mesoridazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with maprotiline.", "severity": 2}
{"drug1": "Propiverine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with buprenorphine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with naratriptan.", "severity": 2}
{"drug1": "tetracaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with felbamate.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with buprenorphine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spiramycin is combined with simvastatin.", "severity": 2}
{"drug1": "bupropion", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupropion is combined with fluoxetine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with anastrozole.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Fluspirilene.", "severity": 2}
{"drug1": "desipramine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with triazolam.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Ketobemidone.", "severity": 2}
{"drug1": "cocaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with dantrolene.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with captopril.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with homoharringtonine.", "severity": 2}
{"drug1": "butamben", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with venlafaxine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with acebutolol.", "severity": 2}
{"drug1": "butamben", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with clemastine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with felbamate.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with procarbazine.", "severity": 2}
{"drug1": "aspirin", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with benazepril.", "severity": 2}
{"drug1": "sulpiride", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with thiopental.", "severity": 2}
{"drug1": "aspirin", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with fenbufen.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Eprosartan.", "severity": 2}
{"drug1": "loxapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with trifluoperazine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with clonazepam.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Bambuterol.", "severity": 2}
{"drug1": "labetalol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with furosemide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with clomipramine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with phenytoin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with clenbuterol.", "severity": 2}
{"drug1": "carprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with equilin.", "severity": 2}
{"drug1": "brotizolam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ketamine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with etizolam.", "severity": 2}
{"drug1": "Aluminium", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aluminium is combined with misoprostol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with nitrous oxide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with simvastatin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Lurasidone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with propoxyphene.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Nebivolol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with nifedipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with papaverine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Eprosartan.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with clofazimine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Salsalate.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with paramethasone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with chlorzoxazone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with zonisamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with ondansetron.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with tiagabine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with salicylamide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with acemetacin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with propofol.", "severity": 2}
{"drug1": "atenolol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with furosemide.", "severity": 2}
{"drug1": "atenolol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Tramadol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with thiopental.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with flumethasone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with AMILORIDE.", "severity": 2}
{"drug1": "clozapine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with nifedipine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Trabectedin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Trabectedin.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with propoxyphene.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with secobarbital.", "severity": 2}
{"drug1": "chlorambucil", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorambucil is combined with clozapine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Eprosartan.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "milrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with milrinone.", "severity": 2}
{"drug1": "epirizole", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with medrysone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with mesoridazine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Etidronic acid.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Quinine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Quinine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with timolol.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clopidogrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIFAPENTINE is combined with clopidogrel.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Quinupristin.", "severity": 2}
{"drug1": "Articaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with maprotiline.", "severity": 2}
{"drug1": "imipramine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with methazolamide.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with diflunisal.", "severity": 2}
{"drug1": "imipramine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Eplerenone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with brotizolam.", "severity": 2}
{"drug1": "amobarbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with fexofenadine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "oxycodone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with GUANFACINE.", "severity": 2}
{"drug1": "aspirin", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with diflunisal.", "severity": 2}
{"drug1": "thioridazine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with mecamylamine.", "severity": 2}
{"drug1": "aspirin", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with dorzolamide.", "severity": 2}
{"drug1": "triamterene", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with VERAPAMIL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nitrous oxide.", "severity": 2}
{"drug1": "carprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Propacetamol.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with meperidine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with vigabatrin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with ropinirole.", "severity": 2}
{"drug1": "furosemide", "drug2": "gentamicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with gentamicin.", "severity": 2}
{"drug1": "terazosin", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Dapagliflozin.", "severity": 2}
{"drug1": "furosemide", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Clobetasone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with metoprolol.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with bepridil.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with SERATRODAST.", "severity": 2}
{"drug1": "loteprednol", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with cinoxacin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with nifedipine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Iloperidone.", "severity": 2}
{"drug1": "alprostadil", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprostadil is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "MEGESTROL ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "thioguanine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with thioguanine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Pipamperone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "aminoglutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with aminoglutethimide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Sacubitril.", "severity": 2}
{"drug1": "nimesulide", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with amcinonide.", "severity": 2}
{"drug1": "Almasilate", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almasilate is combined with misoprostol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with prednisone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Ramelteon.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with primidone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with imipramine.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with nefazodone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Canagliflozin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprenolol is combined with pilocarpine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Ketobemidone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with MOLINDONE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with papaverine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with brotizolam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with dexamethasone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with flumethasone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with salicylamide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nisoldipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Articaine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Sacubitril.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with rescinnamine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "docetaxel", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with mycophenolic acid.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Amrinone.", "severity": 2}
{"drug1": "loxapine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Pipamperone.", "severity": 2}
{"drug1": "loxapine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with triazolam.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with zonisamide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Fospropofol.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Naftifine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with clozapine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Halobetasol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with tiagabine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with selegiline.", "severity": 2}
{"drug1": "ketamine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with tiapride.", "severity": 2}
{"drug1": "Butethal", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with primidone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with sertraline.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with diclofenac.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with enalapril.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with fleroxacin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Perospirone.", "severity": 2}
{"drug1": "captopril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with isoxsuprine.", "severity": 2}
{"drug1": "medrysone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with clidinium.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Boceprevir is combined with oxycodone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with barnidipine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with vinblastine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with digoxin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Etidronic acid.", "severity": 2}
{"drug1": "methadone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with zotepine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Pipamperone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Etidocaine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with citalopram.", "severity": 2}
{"drug1": "fosinopril", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with D-mannitol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ZILEUTON.", "severity": 2}
{"drug1": "azelastine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with prednisone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with etodolac.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotiazepam is combined with atorvastatin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "terazosin", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Metipranolol.", "severity": 2}
{"drug1": "terazosin", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "promazine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with nitrazepam.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with propoxyphene.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with MOLINDONE.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with halcinonide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Olopatadine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with methyclothiazide.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with difluprednate.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with doxepin.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with nicardipine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with clomipramine.", "severity": 2}
{"drug1": "promazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with butalbital.", "severity": 2}
{"drug1": "codeine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with triflupromazine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with enalapril.", "severity": 2}
{"drug1": "perphenazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with equilin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with tubocurarine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with antipyrine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with sertraline.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Metixene.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Metipranolol.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with pancuronium.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "temazepam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Perospirone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nimodipine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with triamcinolone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with GUANFACINE.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Ketobemidone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with primidone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with tolazoline.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "moclobemide", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with trifluoperazine.", "severity": 2}
{"drug1": "butalbital", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with citalopram.", "severity": 2}
{"drug1": "metaraminol", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with PROCATEROL.", "severity": 2}
{"drug1": "tropicamide", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with pancuronium.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Milnacipran.", "severity": 2}
{"drug1": "HEROIN", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "clemastine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ketamine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "ketamine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with flunitrazepam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with DESFLURANE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Normethadone.", "severity": 2}
{"drug1": "naratriptan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with periciazine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with atorvastatin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "tropicamide", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with oxymorphone.", "severity": 2}
{"drug1": "clidinium", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with primidone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Retigabine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Canagliflozin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with etizolam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Fospropofol.", "severity": 2}
{"drug1": "triazolam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Flibanserin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with vigabatrin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with dyclonine.", "severity": 2}
{"drug1": "aspirin", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with acemetacin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Fencamfamin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Fluspirilene.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Cyamemazine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with flunarizine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Icatibant.", "severity": 2}
{"drug1": "propofol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with tiapride.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Aliskiren.", "severity": 2}
{"drug1": "risperidone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Etidocaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Propoxycaine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Levomilnacipran.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Melatonin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Lapatinib.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with etizolam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Fluspirilene.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with flunarizine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with dantrolene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with tiapride.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with flunisolide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Milnacipran.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Melatonin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Enalaprilat.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with Canagliflozin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with diflorasone.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with butorphanol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with lidocaine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with homoharringtonine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with paramethasone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with flunitrazepam.", "severity": 2}
{"drug1": "ethanol", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Phenelzine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with promethazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with clonazepam.", "severity": 2}
{"drug1": "promethazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with methazolamide.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with hydromorphone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with budesonide.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with trimipramine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with haloperidol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with rivastigmine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with trimipramine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with D-mannitol.", "severity": 2}
{"drug1": "methysergide", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with methylprednisolone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Fencamfamin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with nortriptyline.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with amoxapine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Etidronic acid.", "severity": 2}
{"drug1": "HEROIN", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with potassium ion.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with phenobarbital.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with bromocriptine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Apremilast.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Perospirone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Pipamperone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with hyoscyamine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with levodopa.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ZILEUTON.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Pipamperone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Normethadone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with triflupromazine.", "severity": 2}
{"drug1": "etizolam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with topiramate.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with salicylic acid.", "severity": 2}
{"drug1": "metolazone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Iloperidone.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Pipazethate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Pipazethate.", "severity": 2}
{"drug1": "metolazone", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with felodipine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "metolazone", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with ouabain.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Metipranolol.", "severity": 2}
{"drug1": "methysergide", "drug2": "ketoconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ketoconazole.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Aliskiren.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Metipranolol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with SERATRODAST.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Desloratadine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with metronidazole.", "severity": 2}
{"drug1": "procaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with clemastine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Agomelatine.", "severity": 2}
{"drug1": "procaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with venlafaxine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with betamethasone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Lorcaserin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Normethadone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Halobetasol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with betamethasone.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Idelalisib is combined with oxycodone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Flibanserin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with HEROIN.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "citalopram", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with duloxetine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with pentazocine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with ketoprofen.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Butethal.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with tetracaine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with meclizine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Hexobarbital.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "proparacaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "benztropine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with butorphanol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "clozapine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with hydralazine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "desipramine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Flibanserin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with irbesartan.", "severity": 2}
{"drug1": "amoxapine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with clenbuterol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with buprenorphine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Zoledronic acid.", "severity": 2}
{"drug1": "leflunomide", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with benzyl alcohol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Normethadone.", "severity": 2}
{"drug1": "sulconazole", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with simvastatin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Efonidipine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with CLONIXIN.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Lacidipine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Droxicam.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with efavirenz.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with CYCLIZINE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with thioridazine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with losartan.", "severity": 2}
{"drug1": "halothane", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with rasagiline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ethanol.", "severity": 2}
{"drug1": "indapamide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with dipyridamole.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with MELPERONE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with isoflurane.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with chlorthalidone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Clodronic Acid.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinorelbine is combined with mitomycin C.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "thiamylal", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with GUANFACINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with trichlormethiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with Isoflurophate.", "severity": 2}
{"drug1": "prednisone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with galanthamine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with linezolid.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Perospirone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Riociguat.", "severity": 2}
{"drug1": "meperidine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with mycophenolic acid.", "severity": 2}
{"drug1": "flunisolide", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with ambenonium.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Apremilast.", "severity": 2}
{"drug1": "pentamidine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with cilnidipine.", "severity": 2}
{"drug1": "equilin", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with sparfloxacin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Risedronic acid.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with SERATRODAST.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with clemastine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with cilazapril.", "severity": 2}
{"drug1": "lisinopril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with suprofen.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with dibucaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Escitalopram.", "severity": 2}
{"drug1": "clorazepate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with methadone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remikiren is combined with cyclophosphamide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Eprosartan.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Retigabine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with chlormezanone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with epirizole.", "severity": 2}
{"drug1": "HEROIN", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with tiapride.", "severity": 2}
{"drug1": "diclofenac", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "propofol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with carisoprodol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with niflumic acid.", "severity": 2}
{"drug1": "selegiline", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with nifedipine.", "severity": 2}
{"drug1": "estazolam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with HEROIN.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with dibucaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with metolazone.", "severity": 2}
{"drug1": "prazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with etizolam.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Pizotifen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with furosemide.", "severity": 2}
{"drug1": "quinidine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Mometasone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Mirabegron.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with METAXALONE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Trospium.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with isocarboxazid.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with phenmetrazine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Indacaterol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with chloral hydrate.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Nebivolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with trimipramine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with thiopental.", "severity": 2}
{"drug1": "floctafenine", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with tenoxicam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with lisinopril.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with dibucaine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with ketorolac.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with metolazone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with penbutolol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with nabumetone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Vecuronium.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "pergolide", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with irinotecan.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Tasimelteon.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Normethadone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Pomalidomide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with pancuronium.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with chlorthalidone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with paramethasone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "benzocaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with ethotoin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with tofisopam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Tolcapone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with Gatifloxacin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Empagliflozin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Milnacipran.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with triflupromazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Icatibant", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with alclofenac.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with prednisone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with diphenhydramine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with fluoxetine.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SIMEPREVIR is combined with mecamylamine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with duloxetine.", "severity": 2}
{"drug1": "quinidine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with topiramate.", "severity": 2}
{"drug1": "methysergide", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with losartan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "tretinoin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with losartan.", "severity": 2}
{"drug1": "celecoxib", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with formestane.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with triflupromazine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Agomelatine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with butalbital.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "temazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with etizolam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with methoxyflurane.", "severity": 2}
{"drug1": "butabarbital", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with meprobamate.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "podophyllotoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with podophyllotoxin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with nalbuphine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Iloperidone.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with felodipine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "IDARUBICIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with IDARUBICIN.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Benidipine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with lidocaine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with glutethimide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with HEROIN.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with formestane.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Lornoxicam.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with tiapride.", "severity": 2}
{"drug1": "trandolapril", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with doxazosin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Arformoterol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with vigabatrin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with labetalol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with oxymorphone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with leflunomide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with lisinopril.", "severity": 2}
{"drug1": "isradipine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with trandolapril.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with zopiclone.", "severity": 2}
{"drug1": "epirizole", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Clodronic Acid.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with diazepam.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with topiramate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with prednisone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with promethazine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Propacetamol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with zotepine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with triamterene.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Etidronic acid.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Difenoxin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with periciazine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "pergolide", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with diazepam.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with Milnacipran.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium acetate is combined with ergocalciferol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with flunitrazepam.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with topiramate.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with halcinonide.", "severity": 2}
{"drug1": "meperidine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with etizolam.", "severity": 2}
{"drug1": "linezolid", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with pimozide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with Spirapril.", "severity": 2}
{"drug1": "celecoxib", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with carprofen.", "severity": 2}
{"drug1": "duloxetine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with nefazodone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Methadyl acetate.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with glutethimide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Lormetazepam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with zotepine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with dyclonine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Torasemide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Desloratadine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ADAPALENE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Torasemide.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with Olsalazine.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Echothiophate is combined with Cevimeline.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Echothiophate is combined with nicotine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with sertraline.", "severity": 2}
{"drug1": "clonazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Thioproperazine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "quazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with cilazapril.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Echothiophate is combined with Varenicline.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with dexamethasone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Tixocortol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "prazosin", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with metolazone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with metolazone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Nebivolol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with etizolam.", "severity": 2}
{"drug1": "captopril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Sacubitril.", "severity": 2}
{"drug1": "chlorambucil", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorambucil is combined with leflunomide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Clodronic Acid.", "severity": 2}
{"drug1": "imipramine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nimodipine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Lorcaserin.", "severity": 2}
{"drug1": "medrysone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with decamethonium.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "epinephrine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with nimodipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with potassium ion.", "severity": 2}
{"drug1": "etodolac", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Etidronic acid.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with alclometasone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Ketobemidone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with bupivacaine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Etomidate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with nitrous oxide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with tizanidine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with tretinoin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with isoflurane.", "severity": 2}
{"drug1": "halcinonide", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with donepezil.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Empagliflozin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with levodopa.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with trichlormethiazide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with cetirizine.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with azelastine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with DESONIDE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with pentazocine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with methoxyflurane.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with ILOPROST.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with nefazodone.", "severity": 2}
{"drug1": "butamben", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "quinapril", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with captopril.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with acebutolol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Fluspirilene.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with flunarizine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with zopiclone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with protriptyline.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with buprenorphine.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetrahydrozoline is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with cetirizine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with mycophenolic acid.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Ketobemidone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with methyclothiazide.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with irbesartan.", "severity": 2}
{"drug1": "codeine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ethosuximide.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with periciazine.", "severity": 2}
{"drug1": "reserpine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Methadyl acetate.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with glutethimide.", "severity": 2}
{"drug1": "buspirone", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with midazolam.", "severity": 2}
{"drug1": "zopiclone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with halothane.", "severity": 2}
{"drug1": "Artemether", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with nimesulide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with thiamylal.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with D-mannitol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with desipramine.", "severity": 2}
{"drug1": "codeine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with AMILORIDE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with bumetanide.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with chlorothiazide.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with quinapril.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Butylscopolamine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with tamoxifen.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "tropicamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with tropicamide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Lacidipine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Normethadone.", "severity": 2}
{"drug1": "brotizolam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with scopolamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Flupentixol.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with furazolidone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with bumetanide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Etidronic acid.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with promethazine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with clonazepam.", "severity": 2}
{"drug1": "reserpine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with spironolactone.", "severity": 2}
{"drug1": "reserpine", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with promazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with ALFENTANIL.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with diflorasone.", "severity": 2}
{"drug1": "reserpine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with triprolidine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Crizotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Crizotinib.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with cilazapril.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Tixocortol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with SERTINDOLE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with ILOPROST.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with bupropion.", "severity": 2}
{"drug1": "spiramycin", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spiramycin is combined with fluvastatin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with tubocurarine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with clorazepate.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with chlorothiazide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with quinapril.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with pentazocine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with bumetanide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with zopiclone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with captopril.", "severity": 2}
{"drug1": "buspirone", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with cinoxacin.", "severity": 2}
{"drug1": "buspirone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with benzocaine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with meclizine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "efavirenz", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with GUANFACINE.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with topiramate.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Remoxipride.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with loxapine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with hydralazine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with dicyclomine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with zonisamide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Halobetasol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Etidocaine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Aceprometazine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with MOLINDONE.", "severity": 2}
{"drug1": "amifostine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with thioridazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with cocaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with tiagabine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with flunisolide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with gabapentin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Ethylmorphine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Dapagliflozin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Metipranolol.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with DESFLURANE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Toloxatone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Pirlindole.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with duloxetine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "PONATINIB", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with PONATINIB.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with azelastine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Ezetimibe.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with formestane.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Levalbuterol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with barnidipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with morphine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with bupivacaine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Ropivacaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with methimazole.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with aspirin.", "severity": 2}
{"drug1": "ramipril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with protriptyline.", "severity": 2}
{"drug1": "diazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "trazodone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with meclizine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with protriptyline.", "severity": 2}
{"drug1": "loratadine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Difenoxin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Propoxycaine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with metoprolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with clorazepate.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Pramocaine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with papaverine.", "severity": 2}
{"drug1": "ramipril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with fenbufen.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with ropinirole.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with cilazapril.", "severity": 2}
{"drug1": "alprazolam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with carisoprodol.", "severity": 2}
{"drug1": "tiagabine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with fluoxetine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with sulpiride.", "severity": 2}
{"drug1": "tiagabine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with duloxetine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with losartan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with tretinoin.", "severity": 2}
{"drug1": "trazodone", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with tranylcypromine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with isoflurane.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with periciazine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Salsalate.", "severity": 2}
{"drug1": "levorphanol", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with tiagabine.", "severity": 2}
{"drug1": "carprofen", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with salicylamide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with selegiline.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Tianeptine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with enalapril.", "severity": 2}
{"drug1": "clozapine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with clenbuterol.", "severity": 2}
{"drug1": "clozapine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with glutethimide.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "nadolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Riociguat.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Bambuterol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Mersalyl.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Pipamperone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with cocaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with topiramate.", "severity": 2}
{"drug1": "Darunavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Darunavir is combined with meperidine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Naftifine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with KETAZOLAM.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with oxprenolol.", "severity": 2}
{"drug1": "sertraline", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Tapentadol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with arsenic trioxide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with prazepam.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with sparfloxacin.", "severity": 2}
{"drug1": "trazodone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Fencamfamin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Metipranolol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with leflunomide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with cetirizine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "codeine", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Mersalyl.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with maprotiline.", "severity": 2}
{"drug1": "josamycin", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when josamycin is combined with Temsirolimus.", "severity": 2}
{"drug1": "morphine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with NITROUS ACID.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "perphenazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with butamben.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with prednisone.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with citalopram.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "pimozide", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with topiramate.", "severity": 2}
{"drug1": "lisinopril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with clidinium.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Arformoterol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with tolfenamic acid.", "severity": 2}
{"drug1": "triprolidine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with clomipramine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trabectedin is combined with leflunomide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with etoposide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Droxicam.", "severity": 2}
{"drug1": "cocaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with METAXALONE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with GUANFACINE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "methadone", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with linezolid.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Pramocaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with benzocaine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Lurasidone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with theobromine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Difenoxin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with mesalamine.", "severity": 2}
{"drug1": "halothane", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Difenoxin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Etidocaine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Normethadone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with salicylic acid.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "mestranol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with mestranol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Apremilast.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Oxetacaine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Tramadol.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "atenolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with penbutolol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with protriptyline.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with paramethasone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Agomelatine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Fospropofol.", "severity": 2}
{"drug1": "tetracaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with amisulpride.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Pipotiazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Halazepam.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with benazepril.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Spectinomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Spectinomycin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with vincristine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Cariprazine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with primidone.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with bepridil.", "severity": 2}
{"drug1": "docetaxel", "drug2": "5-Fluorouracil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "docetaxel", "drug2": "azelaic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with azelaic acid.", "severity": 2}
{"drug1": "Articaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Normethadone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Tramadol.", "severity": 2}
{"drug1": "miconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Benidipine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with tiapride.", "severity": 2}
{"drug1": "methadone", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with cyclothiazide.", "severity": 2}
{"drug1": "imipramine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with clomipramine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with bumetanide.", "severity": 2}
{"drug1": "imipramine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with isocarboxazid.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "CABAZITAXEL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "promazine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Icatibant.", "severity": 2}
{"drug1": "promazine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "promazine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with triazolam.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with diflunisal.", "severity": 2}
{"drug1": "lithium ion", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with efavirenz.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with methylprednisolone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with leflunomide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Indacaterol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with nimesulide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with propofol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Clevidipine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with linezolid.", "severity": 2}
{"drug1": "sulindac", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Olopatadine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Difenoxin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Tramadol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with D-mannitol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Canagliflozin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with fexofenadine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with butalbital.", "severity": 2}
{"drug1": "methadone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with bumetanide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Propacetamol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with bromazepam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with butamben.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprenolol is combined with Varenicline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with fexofenadine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with dantrolene.", "severity": 2}
{"drug1": "Perospirone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with zotepine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with MELPERONE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Oxetacaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with vigabatrin.", "severity": 2}
{"drug1": "topiramate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with GUANFACINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with oxymorphone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Amrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Amrubicin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with budesonide.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Flibanserin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with fludiazepam.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Pizotifen.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Levetiracetam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with dibucaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with desipramine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with codeine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with thiamylal.", "severity": 2}
{"drug1": "methysergide", "drug2": "sulfisoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with sulfisoxazole.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with leflunomide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Bretylium.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with halothane.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with droperidol.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with butalbital.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with apraclonidine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with budesonide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "zotepine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with primidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with clidinium.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nisoldipine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with rivastigmine.", "severity": 2}
{"drug1": "bepridil", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "alprostadil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tadalafil is combined with alprostadil.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Remoxipride.", "severity": 2}
{"drug1": "triazolam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Articaine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Pipamperone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Loxoprofen.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Droxicam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with mirtazapine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with haloperidol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with CLONIXIN.", "severity": 2}
{"drug1": "meperidine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with zotepine.", "severity": 2}
{"drug1": "meperidine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with MELPERONE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with zotepine.", "severity": 2}
{"drug1": "aspirin", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Tixocortol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Lormetazepam.", "severity": 2}
{"drug1": "loteprednol", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with NICORANDIL.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Ethylmorphine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with methocarbamol.", "severity": 2}
{"drug1": "terconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with triprolidine.", "severity": 2}
{"drug1": "losartan", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Icatibant.", "severity": 2}
{"drug1": "Melatonin", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with meclizine.", "severity": 2}
{"drug1": "loxapine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with fludiazepam.", "severity": 2}
{"drug1": "nabumetone", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with homoharringtonine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with enflurane.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "reserpine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with METAXALONE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with VERAPAMIL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with MELPERONE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with acemetacin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with HEROIN.", "severity": 2}
{"drug1": "nimodipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with bumetanide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with topiramate.", "severity": 2}
{"drug1": "nimodipine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with quinapril.", "severity": 2}
{"drug1": "nimodipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with budesonide.", "severity": 2}
{"drug1": "temazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with doxepin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with OLODATEROL.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with amcinonide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Cyamemazine.", "severity": 2}
{"drug1": "procaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Ketobemidone.", "severity": 2}
{"drug1": "benazepril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Loxoprofen.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "procaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "dopamine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "benazepril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with CLONIXIN.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with clozapine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "Butethal", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Escitalopram.", "severity": 2}
{"drug1": "Butethal", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Eprosartan.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with butamben.", "severity": 2}
{"drug1": "ketamine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with lithium ion.", "severity": 2}
{"drug1": "flurazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with tiagabine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "tirofiban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with tirofiban.", "severity": 2}
{"drug1": "ketamine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Butethal.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "alprostadil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with alprostadil.", "severity": 2}
{"drug1": "ketamine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with amobarbital.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Cyamemazine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atomoxetine is combined with Flibanserin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with zonisamide.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with clomipramine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Toloxatone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Potassium citrate.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with sulpiride.", "severity": 2}
{"drug1": "amiodarone", "drug2": "amphotericin b", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with amphotericin b.", "severity": 2}
{"drug1": "sulconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with flunarizine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Pinaverium.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Flibanserin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with physostigmine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Azelnidipine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Mometasone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with rivastigmine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with pentazocine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with difluprednate.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with halcinonide.", "severity": 2}
{"drug1": "quinidine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with orphenadrine.", "severity": 2}
{"drug1": "etizolam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with ethosuximide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with terazosin.", "severity": 2}
{"drug1": "valsartan", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with triprolidine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with DESFLURANE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Escitalopram.", "severity": 2}
{"drug1": "triazolam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with memantine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SAQUINAVIR is combined with toremifene.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with nicardipine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SAQUINAVIR is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with amitriptyline.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Tolcapone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with METAXALONE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Rosuvastatin.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Olopatadine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with dipyridamole.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Olopatadine.", "severity": 2}
{"drug1": "propofol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with oxprenolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with clonidine.", "severity": 2}
{"drug1": "ketamine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with ethotoin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with isoxsuprine.", "severity": 2}
{"drug1": "estazolam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with amitriptyline.", "severity": 2}
{"drug1": "ketamine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with prilocaine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Tolcapone.", "severity": 2}
{"drug1": "ketamine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with tranylcypromine.", "severity": 2}
{"drug1": "halothane", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with NITROUS ACID.", "severity": 2}
{"drug1": "malathion", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when malathion is combined with acetylcholine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ramipril", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with lisinopril.", "severity": 2}
{"drug1": "propofol", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Remoxipride.", "severity": 2}
{"drug1": "isoflurane", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with DEZOCINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with nitroglycerin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Levocetirizine.", "severity": 2}
{"drug1": "propofol", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nisoldipine.", "severity": 2}
{"drug1": "citalopram", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with sulpiride.", "severity": 2}
{"drug1": "imipramine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Eprosartan.", "severity": 2}
{"drug1": "propofol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nadolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Levetiracetam.", "severity": 2}
{"drug1": "prazosin", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Aliskiren.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with trichlormethiazide.", "severity": 2}
{"drug1": "codeine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with trazodone.", "severity": 2}
{"drug1": "tolazoline", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with tretinoin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with methoxyflurane.", "severity": 2}
{"drug1": "protriptyline", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "propantheline", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with morphine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with sulpiride.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Mersalyl.", "severity": 2}
{"drug1": "butabarbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with clidinium.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with sertraline.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Methadyl acetate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with zopiclone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with norfloxacin.", "severity": 2}
{"drug1": "etizolam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with olanzapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with oxymorphone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with dexamethasone.", "severity": 2}
{"drug1": "doxepin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Retigabine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Fluspirilene.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with DEZOCINE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with periciazine.", "severity": 2}
{"drug1": "metolazone", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with nifedipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with papaverine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Levetiracetam.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with antipyrine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Pomalidomide.", "severity": 2}
{"drug1": "loxapine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Fluspirilene.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with fenoprofen.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Cyamemazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "loxapine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with flunarizine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with levodopa.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "meclizine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with baclofen.", "severity": 2}
{"drug1": "quinapril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with penbutolol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with procarbazine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Zoledronic acid.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Retigabine.", "severity": 2}
{"drug1": "halothane", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with meclizine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with quinidine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with selegiline.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with ketamine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with amcinonide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with tenoxicam.", "severity": 2}
{"drug1": "Salsalate", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with bromazepam.", "severity": 2}
{"drug1": "floctafenine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with scopolamine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with tiapride.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Retigabine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with flunarizine.", "severity": 2}
{"drug1": "Benidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Riociguat.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with oxymorphone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with amoxapine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with nortriptyline.", "severity": 2}
{"drug1": "brotizolam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with baclofen.", "severity": 2}
{"drug1": "sertraline", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Dothiepin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Flibanserin.", "severity": 2}
{"drug1": "estazolam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with prazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with quazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "estazolam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with oxprenolol.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with nifedipine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with CYCLIZINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with nefazodone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with bumetanide.", "severity": 2}
{"drug1": "dyclonine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with doxepin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with loteprednol.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Flibanserin.", "severity": 2}
{"drug1": "clonidine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with AMILORIDE.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Pregabalin.", "severity": 2}
{"drug1": "halothane", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Dapagliflozin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Milnacipran.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with lisinopril.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with nitroglycerin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with fenbufen.", "severity": 2}
{"drug1": "dibucaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with imipramine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Articaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with glutethimide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with desoximetasone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Retigabine.", "severity": 2}
{"drug1": "sotalol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with mecamylamine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with nortriptyline.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with amoxapine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with clidinium.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with pimozide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Propoxycaine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Pramocaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Aceprometazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with MOLINDONE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Rotigotine.", "severity": 2}
{"drug1": "enflurane", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with dyclonine.", "severity": 2}
{"drug1": "enflurane", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with propoxyphene.", "severity": 2}
{"drug1": "atenolol", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with timolol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "aspirin", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with SERATRODAST.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Olopatadine.", "severity": 2}
{"drug1": "morphine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Riociguat.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with clonidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Eplerenone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with benazepril.", "severity": 2}
{"drug1": "quinapril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with flunarizine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Tixocortol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with flunitrazepam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with SUFENTANIL.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with minoxidil.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Articaine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with alclofenac.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with apraclonidine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ketoprofen.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with thiopental.", "severity": 2}
{"drug1": "celecoxib", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with medrysone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with flunitrazepam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with AMILORIDE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ethosuximide.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Etidocaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with doxazosin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "aspirin", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with zaltoprofen.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with glutethimide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Olopatadine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with rivastigmine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Clevidipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with clidinium.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with physostigmine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Flibanserin.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Pimecrolimus.", "severity": 2}
{"drug1": "paroxetine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with sulpiride.", "severity": 2}
{"drug1": "perphenazine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "baclofen", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with ethotoin.", "severity": 2}
{"drug1": "valsartan", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with nabumetone.", "severity": 2}
{"drug1": "meperidine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with naratriptan.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "meperidine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with fexofenadine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Cis-mdp.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with efavirenz.", "severity": 2}
{"drug1": "codeine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with moclobemide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfadiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfadiazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with dipyridamole.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with ropinirole.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with doxepin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Metipranolol.", "severity": 2}
{"drug1": "buspirone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with promethazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with suprofen.", "severity": 2}
{"drug1": "diazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with etizolam.", "severity": 2}
{"drug1": "prazosin", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with bumetanide.", "severity": 2}
{"drug1": "lomustine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lomustine is combined with clozapine.", "severity": 2}
{"drug1": "benazepril", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "bifonazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with flunarizine.", "severity": 2}
{"drug1": "prazosin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with quinapril.", "severity": 2}
{"drug1": "prazosin", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with chlorothiazide.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when IDARUBICIN is combined with leflunomide.", "severity": 2}
{"drug1": "clozapine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with quinidine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with haloperidol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Pramocaine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with thiothixene.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with galanthamine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Propoxycaine.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Ethylmorphine.", "severity": 2}
{"drug1": "codeine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with isocarboxazid.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with clonidine.", "severity": 2}
{"drug1": "butamben", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with zonisamide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with duloxetine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with alclofenac.", "severity": 2}
{"drug1": "butamben", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with tiagabine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with diflorasone.", "severity": 2}
{"drug1": "pergolide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with rivastigmine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with acetazolamide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "6-Mercaptopurine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with oxazepam.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with efavirenz.", "severity": 2}
{"drug1": "alprazolam", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with nalbuphine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with donepezil.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Mephobarbital.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with atorvastatin.", "severity": 2}
{"drug1": "quazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "linezolid", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Lorcaserin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Iloperidone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with cocaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with thalidomide.", "severity": 2}
{"drug1": "pergolide", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with KETAZOLAM.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with ondansetron.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with thioridazine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Fesoterodine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with levodopa.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nimodipine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "pergolide", "drug2": "tamoxifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with tamoxifen.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with thiopental.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with labetalol.", "severity": 2}
{"drug1": "pergolide", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with losartan.", "severity": 2}
{"drug1": "chloroxine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with nimesulide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with AMILORIDE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ethosuximide.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Naftifine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with dipyridamole.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with doxazosin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with betamethasone.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with zonisamide.", "severity": 2}
{"drug1": "sertraline", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with amoxapine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with tiagabine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Difenoxin.", "severity": 2}
{"drug1": "temazepam", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with pentazocine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with protriptyline.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Salbutamol.", "severity": 2}
{"drug1": "isradipine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with oxycodone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nimodipine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Agomelatine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with dextromethorphan.", "severity": 2}
{"drug1": "Tramadol", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with DESFLURANE.", "severity": 2}
{"drug1": "reserpine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "lomustine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lomustine is combined with leflunomide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with triamterene.", "severity": 2}
{"drug1": "clozapine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "quazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Canagliflozin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Ziprasidone.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with salicylamide.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with oxybutynin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nicardipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with efavirenz.", "severity": 2}
{"drug1": "Perospirone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with dantrolene.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with butalbital.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with malathion.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with promethazine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with dibucaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ouabain.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with isoxsuprine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "lithium ion", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with triprolidine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Iloperidone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with methylphenidate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with methocarbamol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Fospropofol.", "severity": 2}
{"drug1": "loxapine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with oxprenolol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with baclofen.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with terazosin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with risperidone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Sacubitril.", "severity": 2}
{"drug1": "trazodone", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Almotriptan.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "abacavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Valganciclovir is combined with abacavir.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Olopatadine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with atorvastatin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with NITROUS ACID.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with brotizolam.", "severity": 2}
{"drug1": "triamterene", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with acebutolol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Droxicam.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with nitrendipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with amisulpride.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Tolvaptan.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "promazine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Levocetirizine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with norfloxacin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with topiramate.", "severity": 2}
{"drug1": "carprofen", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with diflunisal.", "severity": 2}
{"drug1": "dantrolene", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with paroxetine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with periciazine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with tiapride.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Risedronic acid.", "severity": 2}
{"drug1": "loteprednol", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with metoclopramide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with triflupromazine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with rapamycin.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with PERHEXILINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "budesonide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with nortriptyline.", "severity": 2}
{"drug1": "Propiverine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with oxycodone.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Fospropofol.", "severity": 2}
{"drug1": "methadone", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Drospirenone.", "severity": 2}
{"drug1": "captopril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Levobupivacaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with MOLINDONE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with KETAZOLAM.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Fencamfamin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Tolcapone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Iloperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with hydromorphone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with leflunomide.", "severity": 2}
{"drug1": "reserpine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Nitroprusside.", "severity": 2}
{"drug1": "loratadine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Levetiracetam.", "severity": 2}
{"drug1": "estazolam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with nitrazepam.", "severity": 2}
{"drug1": "midazolam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with halothane.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with cinnarizine.", "severity": 2}
{"drug1": "dapsone", "drug2": "nitrofurantoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with nitrofurantoin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ketorolac.", "severity": 2}
{"drug1": "pentamidine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with nabumetone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with diflorasone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with GUANFACINE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with tenoxicam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Canagliflozin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "quinacrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with quinacrine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "phenindione", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with phenindione.", "severity": 2}
{"drug1": "duloxetine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with amisulpride.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with tranylcypromine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with MOLINDONE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Levocetirizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Aceprometazine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with reserpine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with halothane.", "severity": 2}
{"drug1": "propofol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nadolol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with desipramine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with thiamylal.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with decamethonium.", "severity": 2}
{"drug1": "lorazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with doxepin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with pyridostigmine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with nitrazepam.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with clomipramine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with phenytoin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with nefazodone.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with hydromorphone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with amoxapine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with estazolam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with zotepine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with nortriptyline.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with dyclonine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with propoxyphene.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with prazepam.", "severity": 2}
{"drug1": "thiopental", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with MOLINDONE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with sulfanilamide.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with doxepin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with nitric oxide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with fexofenadine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with baclofen.", "severity": 2}
{"drug1": "alprazolam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with imipramine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with meclizine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with meperidine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with galanthamine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Isoflurophate.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with ethchlorvynol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with haloperidol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with CLONIXIN.", "severity": 2}
{"drug1": "pramipexole", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Tixocortol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with trandolapril.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with felodipine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with prilocaine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with epirizole.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with irbesartan.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with linezolid.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Clevidipine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Retigabine.", "severity": 2}
{"drug1": "clidinium", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with sertraline.", "severity": 2}
{"drug1": "methysergide", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with tioconazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Levocetirizine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with enflurane.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with procarbazine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with propofol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Risedronic acid.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with triazolam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with nimesulide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with thiamylal.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with vigabatrin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with amisulpride.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Bambuterol.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with resveratrol.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Pizotifen.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Perospirone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with trimipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with quetiapine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with ketamine.", "severity": 2}
{"drug1": "butamben", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with ethosuximide.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with tolterodine.", "severity": 2}
{"drug1": "procaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with dantrolene.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with Demecarium.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Levetiracetam.", "severity": 2}
{"drug1": "benztropine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Riociguat.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with histamine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with flunarizine.", "severity": 2}
{"drug1": "terconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Topiroxostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Topiroxostat.", "severity": 2}
{"drug1": "sildenafil", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sildenafil is combined with oxycodone.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with rosiglitazone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with dexamethasone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with sotalol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Vilazodone.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Ketobemidone.", "severity": 2}
{"drug1": "ritodrine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with isoxsuprine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with mirtazapine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Nepafenac.", "severity": 2}
{"drug1": "dobutamine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with nylidrin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Aceprometazine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Lacidipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with gabapentin.", "severity": 2}
{"drug1": "midodrine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with isoproterenol.", "severity": 2}
{"drug1": "pramipexole", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with atenolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "midodrine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with Ephedrine.", "severity": 2}
{"drug1": "furosemide", "drug2": "metrizamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with metrizamide.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with loxapine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with epirizole.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "resveratrol", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with zotepine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with dobutamine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with gabapentin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with procarbazine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Eplerenone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with methazolamide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with zotepine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Metipranolol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Mersalyl.", "severity": 2}
{"drug1": "fenbufen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with formestane.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with Canagliflozin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with triamcinolone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Lormetazepam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with amitriptyline.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Tolcapone.", "severity": 2}
{"drug1": "folinic acid", "drug2": "tegafur", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when folinic acid is combined with tegafur.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Levomilnacipran.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with acemetacin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with etizolam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with etizolam.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Isometheptene.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with tizanidine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Olaparib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Olaparib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Benidipine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Clodronic Acid.", "severity": 2}
{"drug1": "sulindac", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with fludrocortisone.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with manidipine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with Trovafloxacin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with chloral hydrate.", "severity": 2}
{"drug1": "trazodone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with metoclopramide.", "severity": 2}
{"drug1": "trazodone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with levodopa.", "severity": 2}
{"drug1": "oxycodone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with HEROIN.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with azelastine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ketoprofen.", "severity": 2}
{"drug1": "Asenapine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with flunitrazepam.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Teriflunomide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with nisoldipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with mirtazapine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Aceclofenac.", "severity": 2}
{"drug1": "astemizole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when astemizole is combined with atorvastatin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with chlorprothixene.", "severity": 2}
{"drug1": "triprolidine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Nitroprusside.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with rasagiline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with mecamylamine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Remoxipride.", "severity": 2}
{"drug1": "betamethasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with ambenonium.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Flupentixol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with levodopa.", "severity": 2}
{"drug1": "timolol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with bumetanide.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with hydromorphone.", "severity": 2}
{"drug1": "codeine", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Pirlindole.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with tiagabine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Salbutamol.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with zonisamide.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with flunarizine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with tiapride.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with atorvastatin.", "severity": 2}
{"drug1": "carboprost trometamol", "drug2": "methylergonovine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboprost trometamol is combined with methylergonovine.", "severity": 2}
{"drug1": "bepridil", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Flibanserin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with ethosuximide.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with barnidipine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with rosiglitazone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with flunitrazepam.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with methyldopa.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Telmisartan.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with apraclonidine.", "severity": 2}
{"drug1": "loxapine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with fexofenadine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with Eplerenone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with prazosin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with nimesulide.", "severity": 2}
{"drug1": "trapidil", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with aspirin.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Olopatadine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Deferasirox.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Milnacipran.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atazanavir is combined with meperidine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with ADAPALENE.", "severity": 2}
{"drug1": "desipramine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Indacaterol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with prazosin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with nortriptyline.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with amoxapine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with isoxsuprine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with manidipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with fluvoxamine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with enflurane.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with Benidipine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with medrysone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with haloperidol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with felbamate.", "severity": 2}
{"drug1": "resveratrol", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with prednisone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with ketoprofen.", "severity": 2}
{"drug1": "resveratrol", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Tolcapone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "prilocaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with amitriptyline.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with protriptyline.", "severity": 2}
{"drug1": "bepridil", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with cetirizine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Lumiracoxib.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with glutethimide.", "severity": 2}
{"drug1": "valsartan", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with VERAPAMIL.", "severity": 2}
{"drug1": "imipramine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Retigabine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with METAXALONE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Pramocaine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with fleroxacin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with amisulpride.", "severity": 2}
{"drug1": "irbesartan", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with fosinopril.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with triflupromazine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with propoxyphene.", "severity": 2}
{"drug1": "sulpiride", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with clonidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Lurasidone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Normethadone.", "severity": 2}
{"drug1": "loxapine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with desipramine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with enflurane.", "severity": 2}
{"drug1": "loxapine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with thiamylal.", "severity": 2}
{"drug1": "brotizolam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with tiapride.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with benzocaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with thiothixene.", "severity": 2}
{"drug1": "Normethadone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with ethosuximide.", "severity": 2}
{"drug1": "Normethadone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with AMILORIDE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with ethosuximide.", "severity": 2}
{"drug1": "Metixene", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with HYDROCODONE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with mitoxantrone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with pyridostigmine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "lomustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with lomustine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "estrone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with ethotoin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Clevidipine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with codeine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with fexofenadine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with trandolapril.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "zotepine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with baclofen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with BISOPROLOL.", "severity": 2}
{"drug1": "benztropine", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with biperiden.", "severity": 2}
{"drug1": "dibucaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with doxepin.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Isoflurophate.", "severity": 2}
{"drug1": "azelastine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with medrysone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "rasagiline", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with perphenazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Elbasvir.", "severity": 2}
{"drug1": "pentazocine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with methoxyflurane.", "severity": 2}
{"drug1": "halothane", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with felodipine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with prilocaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with ethotoin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with paroxetine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with ethotoin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Levalbuterol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with droxidopa.", "severity": 2}
{"drug1": "zaleplon", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with doxepin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with prilocaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Nitroprusside.", "severity": 2}
{"drug1": "proparacaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with fluoxetine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Fluspirilene.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Iloperidone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with duloxetine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Vilazodone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with papaverine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with citalopram.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with doxepin.", "severity": 2}
{"drug1": "chloroxine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with nicardipine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with fluoxetine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with suprofen.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with bupivacaine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Ropivacaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with ethotoin.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Tasimelteon.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Clobetasone.", "severity": 2}
{"drug1": "valsartan", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with nadolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with brimonidine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with imipramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ILOPROST.", "severity": 2}
{"drug1": "bumetanide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "desipramine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with terbutaline.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with Levomilnacipran.", "severity": 2}
{"drug1": "propofol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Agomelatine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Idelalisib is combined with atorvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with pilocarpine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with loratadine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with triazolam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "baclofen", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with fexofenadine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with nylidrin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with felbamate.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with fluocinonide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with methoxyflurane.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "pergolide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with fluoxetine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with trichlormethiazide.", "severity": 2}
{"drug1": "methadone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with topiramate.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with rasagiline.", "severity": 2}
{"drug1": "proguanil", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proguanil is combined with dapsone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with hydrocortisone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Clevidipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with chlorprothixene.", "severity": 2}
{"drug1": "captopril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with tolmetin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with propranolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with clotiazepam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with nitrazepam.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with clonidine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Difenoxin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with trazodone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Benidipine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Azelnidipine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Levomilnacipran.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Canagliflozin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Lacidipine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with manidipine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with BISOPROLOL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Desloratadine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Retigabine.", "severity": 2}
{"drug1": "quinidine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with DEZOCINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nitrendipine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with bromazepam.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with etizolam.", "severity": 2}
{"drug1": "estazolam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with lidocaine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with atorvastatin.", "severity": 2}
{"drug1": "sulconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with felodipine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with dexamethasone.", "severity": 2}
{"drug1": "midazolam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with enflurane.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with nicardipine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with chlorprothixene.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with mequitazine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Telmisartan.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with apraclonidine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Pramocaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Pipamperone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with methyldopa.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with triflupromazine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ibuprofen.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Loxoprofen.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Nebivolol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with propoxyphene.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with codeine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with dyclonine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Droxicam.", "severity": 2}
{"drug1": "terbutaline", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with minoxidil.", "severity": 2}
{"drug1": "prednisone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with NICORANDIL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with bicalutamide.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with gabapentin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with mirtazapine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Pipamperone.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with pentazocine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with procaine.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Milnacipran.", "severity": 2}
{"drug1": "propofol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with flunitrazepam.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Empagliflozin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with clomipramine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Asenapine.", "severity": 2}
{"drug1": "linezolid", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Thioproperazine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with isocarboxazid.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Tolvaptan.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with methocarbamol.", "severity": 2}
{"drug1": "selegiline", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with mesoridazine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Eplerenone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Escitalopram.", "severity": 2}
{"drug1": "selegiline", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with maprotiline.", "severity": 2}
{"drug1": "physostigmine", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when physostigmine is combined with acetylcholine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Salmeterol.", "severity": 2}
{"drug1": "quinapril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with leflunomide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with propoxyphene.", "severity": 2}
{"drug1": "perphenazine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with dyclonine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Ezetimibe.", "severity": 2}
{"drug1": "brotizolam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with clonidine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with AMILORIDE.", "severity": 2}
{"drug1": "levallorphan", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levallorphan is combined with Naloxegol.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Tramadol.", "severity": 2}
{"drug1": "reserpine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with furosemide.", "severity": 2}
{"drug1": "amantadine", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amantadine is combined with memantine.", "severity": 2}
{"drug1": "enflurane", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with flunarizine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with labetalol.", "severity": 2}
{"drug1": "formestane", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with tubocurarine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with butamben.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with prednisone.", "severity": 2}
{"drug1": "buspirone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with HEROIN.", "severity": 2}
{"drug1": "thioridazine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with lisinopril.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with desoximetasone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with dyclonine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with doxorubicin.", "severity": 2}
{"drug1": "temazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with bromocriptine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Cariprazine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Remoxipride.", "severity": 2}
{"drug1": "tretinoin", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with reserpine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with nitroglycerin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Dapagliflozin.", "severity": 2}
{"drug1": "valsartan", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with trifluoperazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with thiothixene.", "severity": 2}
{"drug1": "efavirenz", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with duloxetine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Pipotiazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with clidinium.", "severity": 2}
{"drug1": "estazolam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "labetalol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with acetylcholine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Etomidate.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with mecamylamine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Ropivacaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with bupivacaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Perospirone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with meperidine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with atenolol.", "severity": 2}
{"drug1": "methadone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with tiapride.", "severity": 2}
{"drug1": "brotizolam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with carisoprodol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with indapamide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with risperidone.", "severity": 2}
{"drug1": "estazolam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with citalopram.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "temazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with ESMOLOL.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "temazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with temazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Pregabalin.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Pipotiazine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with tiapride.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with clidinium.", "severity": 2}
{"drug1": "temazepam", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with oxazepam.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with carisoprodol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with flunitrazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "meperidine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with levorphanol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "quinidine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Desloratadine.", "severity": 2}
{"drug1": "meperidine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with perphenazine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with protriptyline.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with promethazine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with cetirizine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Clevidipine.", "severity": 2}
{"drug1": "topiramate", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with chlorzoxazone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with BISOPROLOL.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with fluocinonide.", "severity": 2}
{"drug1": "barnidipine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with cilazapril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with potassium ion.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with oxymorphone.", "severity": 2}
{"drug1": "meperidine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with pimozide.", "severity": 2}
{"drug1": "meperidine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with sertraline.", "severity": 2}
{"drug1": "selegiline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Milnacipran.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with acetazolamide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with GUANFACINE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with equilin.", "severity": 2}
{"drug1": "trazodone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Aceprometazine.", "severity": 2}
{"drug1": "baclofen", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with amoxapine.", "severity": 2}
{"drug1": "baclofen", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with nortriptyline.", "severity": 2}
{"drug1": "meclizine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Escitalopram.", "severity": 2}
{"drug1": "meclizine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with MOLINDONE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with MELPERONE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Ramelteon.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with medrysone.", "severity": 2}
{"drug1": "pimozide", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with chlorpheniramine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with moclobemide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with brotizolam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with dextromethorphan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with dantrolene.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with proparacaine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with tolterodine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with maprotiline.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with buspirone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with oxycodone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with cinoxacin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Pipamperone.", "severity": 2}
{"drug1": "lamivudine", "drug2": "Emtricitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lamivudine is combined with Emtricitabine.", "severity": 2}
{"drug1": "Artemether", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with diltiazem.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Milnacipran.", "severity": 2}
{"drug1": "terconazole", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "pentazocine", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with potassium ion.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with GUANFACINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with amisulpride.", "severity": 2}
{"drug1": "furazolidone", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with metaproterenol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with oxymorphone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Nebivolol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with triamterene.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Bexarotene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlortetracycline is combined with Bexarotene.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Fluspirilene.", "severity": 2}
{"drug1": "dibucaine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with tranylcypromine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with amoxapine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Etidocaine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with nortriptyline.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nicergoline", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with ethotoin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with tiapride.", "severity": 2}
{"drug1": "meprobamate", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with prilocaine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with tranylcypromine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with isoflurane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with triprolidine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with nicotine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Cevimeline.", "severity": 2}
{"drug1": "clorazepate", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with methocarbamol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "scopolamine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with protriptyline.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with SERATRODAST.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with sevoflurane.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with cetirizine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with clozapine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with flunarizine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with zaltoprofen.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Aceclofenac.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with alclofenac.", "severity": 2}
{"drug1": "butabarbital", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "butalbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Difenoxin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Mometasone.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with gabapentin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with cetirizine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "dicumarol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with dicumarol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with venlafaxine.", "severity": 2}
{"drug1": "Bazedoxifene", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bazedoxifene is combined with Ospemifene.", "severity": 2}
{"drug1": "meprobamate", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with clemastine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with VERAPAMIL.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with loteprednol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Asenapine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with quetiapine.", "severity": 2}
{"drug1": "trazodone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with zotepine.", "severity": 2}
{"drug1": "trazodone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with MELPERONE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with potassium ion.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Normethadone.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with paroxetine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with tizanidine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with betaxolol.", "severity": 2}
{"drug1": "quazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with furosemide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Apremilast.", "severity": 2}
{"drug1": "tetracaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with duloxetine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Pomalidomide.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with tizanidine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with furosemide.", "severity": 2}
{"drug1": "topotecan", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topotecan is combined with atorvastatin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with sotalol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Nabilone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with brimonidine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Propoxycaine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with hydralazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Butethal.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with pyridostigmine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with hydralazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Hexobarbital.", "severity": 2}
{"drug1": "sulfamethizole", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamethizole is combined with mecamylamine.", "severity": 2}
{"drug1": "linezolid", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with MOLINDONE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with D-mannitol.", "severity": 2}
{"drug1": "linezolid", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Aceprometazine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with zaltoprofen.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with scopolamine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Desloratadine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Remoxipride.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Riociguat.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with mefloquine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with methazolamide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with salicylamide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Telmisartan.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with DEZOCINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Metipranolol.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Pinaverium.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with epirizole.", "severity": 2}
{"drug1": "enalapril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "meperidine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with paroxetine.", "severity": 2}
{"drug1": "selegiline", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with periciazine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with nitroglycerin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Riociguat.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with prilocaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with phenobarbital.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with estrone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with halothane.", "severity": 2}
{"drug1": "Limaprost", "drug2": "ACENOCOUMAROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "meprobamate", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with thiamylal.", "severity": 2}
{"drug1": "meprobamate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with desipramine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with HEROIN.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with dexamethasone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with metolazone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with CARTEOLOL.", "severity": 2}
{"drug1": "bepridil", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Levalbuterol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Empagliflozin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Lercanidipine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with flunisolide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Mirabegron.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with chloral hydrate.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with fludiazepam.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with oxycodone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with tretinoin.", "severity": 2}
{"drug1": "tiapride", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with glutethimide.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with fenbufen.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Remoxipride.", "severity": 2}
{"drug1": "Apremilast", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with fluocinonide.", "severity": 2}
{"drug1": "imipramine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with mecamylamine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Rotigotine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "topiramate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Olopatadine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with fludrocortisone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with niflumic acid.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with budesonide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Melatonin", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with oxprenolol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Ciclesonide.", "severity": 2}
{"drug1": "temazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "ethotoin", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with maprotiline.", "severity": 2}
{"drug1": "benazepril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with tolmetin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ticagrelor is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with methyldopa.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Ditazole.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Crizotinib is combined with Flibanserin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with thiothixene.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Thioproperazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Mirabegron.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Etoricoxib.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with chlormezanone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Telmisartan.", "severity": 2}
{"drug1": "lorazepam", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with thioridazine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with anastrozole.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with phenobarbital.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with methyldopa.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with doxazosin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Halazepam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with proparacaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with baclofen.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with indapamide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Naloxegol.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with periciazine.", "severity": 2}
{"drug1": "butalbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with scopolamine.", "severity": 2}
{"drug1": "baclofen", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with nefazodone.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 3,4-Dihydroxybenzaldehyde is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "olanzapine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with methylphenidate.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Canagliflozin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with diflorasone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with triprolidine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with benazepril.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with epirizole.", "severity": 2}
{"drug1": "halothane", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with SERTINDOLE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with MELPERONE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with zotepine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with rizatriptan.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with cilazapril.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with dantrolene.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with dipyridamole.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with fexofenadine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with protriptyline.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with tiapride.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Paliperidone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with acemetacin.", "severity": 2}
{"drug1": "zotepine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with cetirizine.", "severity": 2}
{"drug1": "zotepine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with protriptyline.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with losartan.", "severity": 2}
{"drug1": "loratadine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Desloratadine.", "severity": 2}
{"drug1": "indapamide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with acebutolol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Canagliflozin.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clenbuterol is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with desipramine.", "severity": 2}
{"drug1": "methysergide", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with anastrozole.", "severity": 2}
{"drug1": "reserpine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with rosiglitazone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with paroxetine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with dipyridamole.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "primidone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with fexofenadine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Telmisartan.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with ethotoin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with enflurane.", "severity": 2}
{"drug1": "quinapril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Aceclofenac.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Lornoxicam.", "severity": 2}
{"drug1": "quinapril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with zaltoprofen.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with ESMOLOL.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with furosemide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with valsartan.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with enalapril.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with baclofen.", "severity": 2}
{"drug1": "Articaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Olopatadine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with brotizolam.", "severity": 2}
{"drug1": "Cyamemazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cyamemazine is combined with methylphenidate.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with ADAPALENE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with tiagabine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with periciazine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with NICORANDIL.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "tiapride", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with primidone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with histamine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "SIMEPREVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "testosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with testosterone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with efavirenz.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with cocaine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nicardipine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Vilanterol.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ACETOPHENAZINE", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ACETOPHENAZINE is combined with methylphenidate.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dichlorphenamide is combined with phenytoin.", "severity": 2}
{"drug1": "amifostine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with D-mannitol.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Icatibant", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with dexamethasone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with nalbuphine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with mirtazapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with MOLINDONE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with pimozide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Riociguat.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Articaine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with acebutolol.", "severity": 2}
{"drug1": "cocaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with carisoprodol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Perospirone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Teriflunomide.", "severity": 2}
{"drug1": "benztropine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Metixene.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with doxorubicin.", "severity": 2}
{"drug1": "methysergide", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with raloxifene.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Pomalidomide.", "severity": 2}
{"drug1": "lorazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with nicardipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with losartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ritodrine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with AMILORIDE.", "severity": 2}
{"drug1": "leflunomide", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with halcinonide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with difluprednate.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Halobetasol.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with NAPROXEN.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Melatonin.", "severity": 2}
{"drug1": "levodopa", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with methylene blue.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "pimozide", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Paliperidone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with amitriptyline.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with toremifene.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Tolcapone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with bumetanide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with Varenicline.", "severity": 2}
{"drug1": "glutethimide", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with clomipramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with benzocaine.", "severity": 2}
{"drug1": "equilin", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with NICORANDIL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with apraclonidine.", "severity": 2}
{"drug1": "halothane", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Milnacipran.", "severity": 2}
{"drug1": "lisinopril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with antipyrine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with trifluoperazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with protriptyline.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Agomelatine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Metipranolol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Aliskiren.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with nalidixic acid.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with chloral hydrate.", "severity": 2}
{"drug1": "proparacaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with levodopa.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Indacaterol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with malathion.", "severity": 2}
{"drug1": "proparacaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "morphine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "trazodone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with pramipexole.", "severity": 2}
{"drug1": "morphine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "imipramine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with spironolactone.", "severity": 2}
{"drug1": "morphine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Eplerenone.", "severity": 2}
{"drug1": "morphine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with methazolamide.", "severity": 2}
{"drug1": "prednisone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with pyridostigmine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with irbesartan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with maprotiline.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with rivastigmine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with felodipine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with proparacaine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with carvedilol.", "severity": 2}
{"drug1": "proparacaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with imipramine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with physostigmine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with diphenhydramine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with desoximetasone.", "severity": 2}
{"drug1": "enalapril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with chloroquine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Temsirolimus.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Nebivolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with sulindac.", "severity": 2}
{"drug1": "tiapride", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "triprolidine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with maprotiline.", "severity": 2}
{"drug1": "prazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with cetirizine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with levodopa.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Etidocaine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "ondansetron", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with chlorprothixene.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with levorphanol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with desipramine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with hydromorphone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Levalbuterol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Conivaptan.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Sacubitril.", "severity": 2}
{"drug1": "triazolam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "methadone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Etidocaine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with enoxacin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with loratadine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with felodipine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with methyclothiazide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with resveratrol.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with methylprednisolone.", "severity": 2}
{"drug1": "losartan", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with epirizole.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Nitroprusside.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with nimesulide.", "severity": 2}
{"drug1": "clonidine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with efavirenz.", "severity": 2}
{"drug1": "clonidine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with nicardipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Levocetirizine.", "severity": 2}
{"drug1": "formestane", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Deferasirox.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Tianeptine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Zoledronic acid.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Normethadone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with levodopa.", "severity": 2}
{"drug1": "butorphanol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with fexofenadine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "trazodone", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Levobupivacaine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with ambenonium.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Aceprometazine.", "severity": 2}
{"drug1": "carprofen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with halcinonide.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with SERATRODAST.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Aceclofenac.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with zaltoprofen.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Pipamperone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with MELPERONE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with zotepine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with fosinopril.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with nilvadipine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with ondansetron.", "severity": 2}
{"drug1": "Etomidate", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with tiagabine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with promethazine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with clonazepam.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with HYDROCODONE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Lormetazepam.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "metoprolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with GUANFACINE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "equilin", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Pefloxacin.", "severity": 2}
{"drug1": "propantheline", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "propofol", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with bromazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Fospropofol.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Pinaverium.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Aceclofenac.", "severity": 2}
{"drug1": "propofol", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with selegiline.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with isoflurane.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with tranylcypromine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with tretinoin.", "severity": 2}
{"drug1": "methadone", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with buspirone.", "severity": 2}
{"drug1": "Riociguat", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Riociguat is combined with isoxsuprine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with mecamylamine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with carisoprodol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with paroxetine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with triamcinolone.", "severity": 2}
{"drug1": "bepridil", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with halothane.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Ketobemidone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with paroxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nortriptyline.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Ziprasidone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with benazepril.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Icatibant.", "severity": 2}
{"drug1": "Perospirone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Apremilast.", "severity": 2}
{"drug1": "sulpiride", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with clonazepam.", "severity": 2}
{"drug1": "tropicamide", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with hydromorphone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Nabilone", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with ramipril.", "severity": 2}
{"drug1": "dibucaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with ethosuximide.", "severity": 2}
{"drug1": "ribavirin", "drug2": "didanosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ribavirin is combined with didanosine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with valsartan.", "severity": 2}
{"drug1": "risperidone", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with gabapentin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with paramethasone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with HEROIN.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with fenbufen.", "severity": 2}
{"drug1": "epirizole", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "equilin", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with physostigmine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with clonazepam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with promethazine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with oxaprozin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with risperidone.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Cangrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Cangrelor.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Agomelatine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Ciclesonide.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with simvastatin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with zonisamide.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "indinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atazanavir is combined with indinavir.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with streptozocin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with methyclothiazide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when galanthamine is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with tiagabine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with zonisamide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with DESFLURANE.", "severity": 2}
{"drug1": "nystatin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Clevidipine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Halobetasol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with risperidone.", "severity": 2}
{"drug1": "nystatin", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with xylometazoline.", "severity": 2}
{"drug1": "alprazolam", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with diphenhydramine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ceritinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ceritinib.", "severity": 2}
{"drug1": "dyclonine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with dantrolene.", "severity": 2}
{"drug1": "methoxamine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with ritodrine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with benzphetamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with butalbital.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with minoxidil.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with oxymetazoline.", "severity": 2}
{"drug1": "haloprogin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with nifedipine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Levalbuterol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with enflurane.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Nebivolol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with MOLINDONE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with etoposide.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Aceprometazine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Potassium citrate.", "severity": 2}
{"drug1": "fosinopril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with CLONIXIN.", "severity": 2}
{"drug1": "papaverine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with isoxsuprine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with flurazepam.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Olopatadine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "imipramine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Loxoprofen.", "severity": 2}
{"drug1": "Torasemide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with dipyridamole.", "severity": 2}
{"drug1": "buspirone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with lithium ion.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with prazepam.", "severity": 2}
{"drug1": "tizanidine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with GUANFACINE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with loxapine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Remoxipride.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with KETAZOLAM.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with amoxapine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with diltiazem.", "severity": 2}
{"drug1": "protriptyline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with clenbuterol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with amitriptyline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Tolcapone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Nitroprusside.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Arformoterol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with DESFLURANE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with oxycodone.", "severity": 2}
{"drug1": "zotepine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with METAXALONE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Flupentixol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with fosinopril.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with tolazoline.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with nefazodone.", "severity": 2}
{"drug1": "valsartan", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with GUANFACINE.", "severity": 2}
{"drug1": "citalopram", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Escitalopram.", "severity": 2}
{"drug1": "Perospirone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with maprotiline.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with mefloquine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with doxepin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Milnacipran.", "severity": 2}
{"drug1": "triprolidine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with amoxapine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with etizolam.", "severity": 2}
{"drug1": "triprolidine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with nortriptyline.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with levorphanol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Halazepam.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with prednisone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Levocetirizine.", "severity": 2}
{"drug1": "sulindac", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with fluocinonide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with amoxapine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with nortriptyline.", "severity": 2}
{"drug1": "methadone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with AMILORIDE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with malathion.", "severity": 2}
{"drug1": "nicergoline", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with dexamethasone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with fosinopril.", "severity": 2}
{"drug1": "Halazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with duloxetine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Etomidate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "indapamide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with captopril.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Ramelteon.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with diflunisal.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clenbuterol is combined with isoxsuprine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazonium is combined with oxycodone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when galanthamine is combined with pilocarpine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with nitroglycerin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Pregabalin.", "severity": 2}
{"drug1": "clozapine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with tolazoline.", "severity": 2}
{"drug1": "clozapine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "etizolam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with triprolidine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Fluspirilene.", "severity": 2}
{"drug1": "pergolide", "drug2": "azithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with azithromycin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with phentolamine.", "severity": 2}
{"drug1": "etizolam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with methocarbamol.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoxsuprine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with thalidomide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with KETAZOLAM.", "severity": 2}
{"drug1": "amoxapine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with celiprolol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with flunarizine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with pargyline.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Oxetacaine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with METAXALONE.", "severity": 2}
{"drug1": "midazolam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "desipramine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Salmeterol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "codeine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with butamben.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with cinoxacin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with clonidine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Salsalate.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Pipamperone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "cilazapril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with epirizole.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Icatibant.", "severity": 2}
{"drug1": "enflurane", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Eprosartan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Difenoxin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with tiapride.", "severity": 2}
{"drug1": "ramipril", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with furosemide.", "severity": 2}
{"drug1": "ramipril", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with dichlorphenamide.", "severity": 2}
{"drug1": "bumetanide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with felodipine.", "severity": 2}
{"drug1": "biperiden", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with pentazocine.", "severity": 2}
{"drug1": "biperiden", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with mecamylamine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with irbesartan.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "clozapine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with benazepril.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Mirabegron.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Bortezomib.", "severity": 2}
{"drug1": "dantrolene", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Mephobarbital.", "severity": 2}
{"drug1": "isoflurane", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with oxazepam.", "severity": 2}
{"drug1": "triazolam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with methocarbamol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with propoxyphene.", "severity": 2}
{"drug1": "gabapentin", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with fexofenadine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with dyclonine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with reserpine.", "severity": 2}
{"drug1": "reserpine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nalbuphine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with medrysone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Normethadone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with tiapride.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pilocarpine is combined with atorvastatin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with malathion.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with DESONIDE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with nalidixic acid.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with quetiapine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with felodipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with mycophenolic acid.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with Gemifloxacin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Pipotiazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Flibanserin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with celecoxib.", "severity": 2}
{"drug1": "Icatibant", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "formestane", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with Gatifloxacin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with trandolapril.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with salicylamide.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with ketoprofen.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with chlormezanone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Ethylmorphine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with tiapride.", "severity": 2}
{"drug1": "etodolac", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with hydrocortisone.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Escitalopram.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Escitalopram.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Metipranolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with MOLINDONE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Ramelteon.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Fosphenytoin.", "severity": 2}
{"drug1": "halothane", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with vigabatrin.", "severity": 2}
{"drug1": "selegiline", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with terbutaline.", "severity": 2}
{"drug1": "enflurane", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with methoxyflurane.", "severity": 2}
{"drug1": "halothane", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ILOPROST.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Tolcapone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with azelastine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Tramadol.", "severity": 2}
{"drug1": "estazolam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with scopolamine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Ciclesonide.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Rotigotine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Ramelteon.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with metyrapone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Mometasone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Ibrutinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Ibrutinib.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Lopinavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metronidazole is combined with Lopinavir.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "betaxolol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with enalapril.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Retigabine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "butabarbital", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with quetiapine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with spironolactone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with butamben.", "severity": 2}
{"drug1": "alprazolam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with dyclonine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with fludrocortisone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with fludrocortisone.", "severity": 2}
{"drug1": "pargyline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Levalbuterol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with tiapride.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with epirizole.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with sevoflurane.", "severity": 2}
{"drug1": "desipramine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with OLODATEROL.", "severity": 2}
{"drug1": "felodipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "desipramine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Vilanterol.", "severity": 2}
{"drug1": "enflurane", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with felbamate.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "DEXKETOPROFEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with DEXKETOPROFEN.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Torasemide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Levomilnacipran.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Flupentixol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Pomalidomide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with indapamide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with suprofen.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Desloratadine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chlormezanone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with oxprenolol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with propranolol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with prazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Salsalate.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with mecamylamine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with sulfasalazine.", "severity": 2}
{"drug1": "halothane", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with minoxidil.", "severity": 2}
{"drug1": "halothane", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Etidocaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with pimozide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with citalopram.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with maprotiline.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ambroxol.", "severity": 2}
{"drug1": "prazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicumarol is combined with Nintedanib.", "severity": 2}
{"drug1": "captopril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Aceclofenac.", "severity": 2}
{"drug1": "etodolac", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with DESONIDE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with quetiapine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with mepivacaine.", "severity": 2}
{"drug1": "captopril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with SERATRODAST.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with aspirin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with bezafibrate.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Apremilast.", "severity": 2}
{"drug1": "cocaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with benzocaine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Temsirolimus.", "severity": 2}
{"drug1": "cocaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with vigabatrin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with PROCATEROL.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Pipamperone.", "severity": 2}
{"drug1": "clonidine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with fludiazepam.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with ethosuximide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Flibanserin.", "severity": 2}
{"drug1": "trazodone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with scopolamine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with GUANFACINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Etidocaine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with thalidomide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "carmustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with carmustine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with amoxapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with nortriptyline.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Levocetirizine.", "severity": 2}
{"drug1": "biperiden", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Mirabegron.", "severity": 2}
{"drug1": "carprofen", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Lornoxicam.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Risedronic acid.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with spironolactone.", "severity": 2}
{"drug1": "procaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with topotecan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with zotepine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with nortriptyline.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with amoxapine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with doxepin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with dipyridamole.", "severity": 2}
{"drug1": "Tramadol", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with buspirone.", "severity": 2}
{"drug1": "suprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with paramethasone.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with efavirenz.", "severity": 2}
{"drug1": "Tramadol", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with oxycodone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Mirabegron.", "severity": 2}
{"drug1": "meperidine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with oxymorphone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with paroxetine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Tramadol.", "severity": 2}
{"drug1": "biperiden", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with nalbuphine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Tixocortol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with sulindac.", "severity": 2}
{"drug1": "lorazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with olanzapine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with venlafaxine.", "severity": 2}
{"drug1": "meperidine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with zopiclone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "imipramine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nicardipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with tizanidine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Pomalidomide.", "severity": 2}
{"drug1": "terbinafine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "lorazepam", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with midazolam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "clemastine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with cetirizine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with isoxsuprine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with prednisone.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with pancuronium.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ethotoin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Tapentadol.", "severity": 2}
{"drug1": "epirizole", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with betamethasone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Levetiracetam.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Sacubitril.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with ergocalciferol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with DEZOCINE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "methadone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with efavirenz.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Pipamperone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with loratadine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with felbamate.", "severity": 2}
{"drug1": "polythiazide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with deslanoside.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with ketoprofen.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfisoxazole is combined with oxycodone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Linagliptin.", "severity": 2}
{"drug1": "imipramine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with OLODATEROL.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with meperidine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with amcinonide.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "azelastine", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with ketoprofen.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Hexobarbital.", "severity": 2}
{"drug1": "metaraminol", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with Nebivolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with etizolam.", "severity": 2}
{"drug1": "clomipramine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with GUANFACINE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with fenbufen.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Clofarabine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with lisinopril.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with ketoprofen.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with amcinonide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with metaproterenol.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with nefazodone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Pregabalin.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Pitavastatin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with vincristine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "azelaic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with azelaic acid.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Ethylmorphine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with HEROIN.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Asenapine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with doxepin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Aripiprazole.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Escitalopram.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with tiagabine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with zonisamide.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Cyamemazine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Niraparib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Niraparib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with glutethimide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with bromazepam.", "severity": 2}
{"drug1": "enalapril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Salsalate.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with bumetanide.", "severity": 2}
{"drug1": "reserpine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with trifluoperazine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with paroxetine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Methadyl acetate.", "severity": 2}
{"drug1": "nefazodone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with oxycodone.", "severity": 2}
{"drug1": "cocaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Pramocaine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Frovatriptan.", "severity": 2}
{"drug1": "pentazocine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with fludiazepam.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with xylometazoline.", "severity": 2}
{"drug1": "procarbazine", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with droperidol.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with isoxsuprine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with propranolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Eplerenone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with clonidine.", "severity": 2}
{"drug1": "methadone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with thiamylal.", "severity": 2}
{"drug1": "sulpiride", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with vigabatrin.", "severity": 2}
{"drug1": "bepridil", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with benzocaine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with chlormezanone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with amisulpride.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with acemetacin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Escitalopram.", "severity": 2}
{"drug1": "Melatonin", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with CYCLIZINE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with hydrocortisone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Lormetazepam.", "severity": 2}
{"drug1": "resveratrol", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with diflunisal.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with lovastatin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with timolol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with proparacaine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Olopatadine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with amisulpride.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Besifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Besifloxacin.", "severity": 2}
{"drug1": "loratadine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Milnacipran.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with protriptyline.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with diltiazem.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with cetirizine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with flunarizine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with MELPERONE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with zotepine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with fludrocortisone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with sertraline.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Aceclofenac.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with azelastine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with propoxyphene.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Flibanserin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with sulindac.", "severity": 2}
{"drug1": "formestane", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with cinoxacin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with triprolidine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with procaine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Clobetasone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with promazine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with periciazine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "manidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when manidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "diazepam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with nitrous oxide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with furosemide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Loxoprofen.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with tizanidine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Articaine.", "severity": 2}
{"drug1": "clidinium", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with flunarizine.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "5-Fluorouracil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levoleucovorin is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Propacetamol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with irbesartan.", "severity": 2}
{"drug1": "butorphanol", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with phenobarbital.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Difenoxin.", "severity": 2}
{"drug1": "methysergide", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with oxymetholone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "aspirin", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with betamethasone.", "severity": 2}
{"drug1": "trazodone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with clonidine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Aceprometazine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with alclometasone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with isradipine.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telithromycin is combined with Abemaciclib.", "severity": 2}
{"drug1": "resveratrol", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with mesalamine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Olopatadine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Olmesartan.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Olopatadine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Eplerenone.", "severity": 2}
{"drug1": "diazepam", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with bromazepam.", "severity": 2}
{"drug1": "medrysone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with edrophonium.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with loteprednol.", "severity": 2}
{"drug1": "losartan", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with trandolapril.", "severity": 2}
{"drug1": "reserpine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "loratadine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with clonazepam.", "severity": 2}
{"drug1": "sulindac", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Risedronic acid.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with nadolol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Empagliflozin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with nitrous oxide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with maprotiline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with vinorelbine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with apraclonidine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with tranylcypromine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with flunarizine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with eperisone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with sotalol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with hydralazine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with meclofenamic acid.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Efonidipine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with fludrocortisone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with isoxsuprine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with mirtazapine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with isocarboxazid.", "severity": 2}
{"drug1": "clomipramine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with epoprostenol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with clindamycin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "loxapine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with trazodone.", "severity": 2}
{"drug1": "biperiden", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Ethylmorphine.", "severity": 2}
{"drug1": "loxapine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with pentazocine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with nifedipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Rotigotine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "haloperidol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with chlormezanone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with lisinopril.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with doxepin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with sparfloxacin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Propoxycaine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Apixaban.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Retigabine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Pipotiazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "meperidine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with diazepam.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with trimipramine.", "severity": 2}
{"drug1": "etizolam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "hexetidine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with nicardipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Sacubitril.", "severity": 2}
{"drug1": "imipramine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with indapamide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with pramipexole.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Tasimelteon.", "severity": 2}
{"drug1": "loxapine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Tasimelteon.", "severity": 2}
{"drug1": "resveratrol", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with tolfenamic acid.", "severity": 2}
{"drug1": "temazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Melatonin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with difluprednate.", "severity": 2}
{"drug1": "clozapine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with MELPERONE.", "severity": 2}
{"drug1": "clozapine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with zotepine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with methylphenidate.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with methocarbamol.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with GUANFACINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Propoxycaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with triprolidine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Aripiprazole.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with methyldopa.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Bretylium.", "severity": 2}
{"drug1": "Etidronic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidronic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "tioconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with bromazepam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Eprosartan.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with pravastatin.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Escitalopram.", "severity": 2}
{"drug1": "ethotoin", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with CYCLIZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with dyclonine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with chloral hydrate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with propoxyphene.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with clozapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Etidronic acid.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "labetalol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with fludiazepam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Propoxycaine.", "severity": 2}
{"drug1": "metolazone", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with acebutolol.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Bretylium.", "severity": 2}
{"drug1": "butabarbital", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with sertraline.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Vilanterol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with OLODATEROL.", "severity": 2}
{"drug1": "triazolam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with enflurane.", "severity": 2}
{"drug1": "proparacaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with clenbuterol.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with acetazolamide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with propofol.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with ethotoin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with bumetanide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with dobutamine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Rivaroxaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Rivaroxaban.", "severity": 2}
{"drug1": "propofol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with enflurane.", "severity": 2}
{"drug1": "triazolam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with clonazepam.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Milnacipran.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with nitrous oxide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with losartan.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with hydrocortisone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Flupentixol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Retigabine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with nitrous oxide.", "severity": 2}
{"drug1": "methysergide", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Ezetimibe.", "severity": 2}
{"drug1": "azelastine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with DESONIDE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with homoharringtonine.", "severity": 2}
{"drug1": "cocaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Cyamemazine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Eplerenone.", "severity": 2}
{"drug1": "bepridil", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with methazolamide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Perospirone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Riociguat.", "severity": 2}
{"drug1": "bepridil", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with SUFENTANIL.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with clonidine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with clonidine.", "severity": 2}
{"drug1": "medrysone", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "ethanol", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with isocarboxazid.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Milnacipran.", "severity": 2}
{"drug1": "Nabilone", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with sertraline.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with promethazine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with chloral hydrate.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with CLONIXIN.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Icatibant.", "severity": 2}
{"drug1": "timolol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with apraclonidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "timolol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Telmisartan.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with topiramate.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with quetiapine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with fludiazepam.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Pomalidomide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Difenoxin.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with formestane.", "severity": 2}
{"drug1": "amiodarone", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with nitric oxide.", "severity": 2}
{"drug1": "procaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "procaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with flunarizine.", "severity": 2}
{"drug1": "halothane", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with isocarboxazid.", "severity": 2}
{"drug1": "procaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with dibucaine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with butalbital.", "severity": 2}
{"drug1": "betamethasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with galanthamine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with methyldopa.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with apraclonidine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Telmisartan.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with ritodrine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with tetracaine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "phenylephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with phenylephrine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with nitrous oxide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with chlorpheniramine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with triamterene.", "severity": 2}
{"drug1": "trazodone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Aceprometazine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with SERATRODAST.", "severity": 2}
{"drug1": "lidocaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with levodopa.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with flurandrenolide.", "severity": 2}
{"drug1": "equilin", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with ambenonium.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with flurandrenolide.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "doxazosin", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with mecamylamine.", "severity": 2}
{"drug1": "carprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "misoprostol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium trisilicate is combined with misoprostol.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with zonisamide.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with methyclothiazide.", "severity": 2}
{"drug1": "morniflumate", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with sulindac.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Olopatadine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Pizotifen.", "severity": 2}
{"drug1": "trazodone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with MOLINDONE.", "severity": 2}
{"drug1": "meclizine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with scopolamine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with nefazodone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Halobetasol.", "severity": 2}
{"drug1": "meperidine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with sumatriptan.", "severity": 2}
{"drug1": "diltiazem", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with GUANFACINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with METAXALONE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with alclometasone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with trandolapril.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with formestane.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with oxaprozin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with penbutolol.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with imipramine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Methadyl acetate.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Metipranolol.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with loratadine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with perphenazine.", "severity": 2}
{"drug1": "pimozide", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with glutethimide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Alvimopan.", "severity": 2}
{"drug1": "meperidine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Tasimelteon.", "severity": 2}
{"drug1": "floctafenine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "clonazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with clomipramine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "clozapine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with METAXALONE.", "severity": 2}
{"drug1": "promethazine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with nefazodone.", "severity": 2}
{"drug1": "butalbital", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with clonidine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with alclofenac.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Levocetirizine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicumarol is combined with Deferasirox.", "severity": 2}
{"drug1": "pentazocine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium phosphate is combined with Calcifediol.", "severity": 2}
{"drug1": "trapidil", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with Olsalazine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Fospropofol.", "severity": 2}
{"drug1": "morphine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Articaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with olanzapine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with diltiazem.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Trovafloxacin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with tizanidine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with azelastine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with dipyridamole.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Mirabegron.", "severity": 2}
{"drug1": "midazolam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with amisulpride.", "severity": 2}
{"drug1": "floctafenine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with prednisone.", "severity": 2}
{"drug1": "sulconazole", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with fluvastatin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "procaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with tiapride.", "severity": 2}
{"drug1": "midazolam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Levocetirizine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with alclofenac.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with butalbital.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Indacaterol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dasatinib is combined with leflunomide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Olopatadine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Agomelatine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with methocarbamol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with zonisamide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with cocaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with tiagabine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with dibucaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with ondansetron.", "severity": 2}
{"drug1": "trimipramine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with isocarboxazid.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with chloroquine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with clomipramine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with sulpiride.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with cyclothiazide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulindac.", "severity": 2}
{"drug1": "maprotiline", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with naratriptan.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with scopolamine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with clomipramine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Pizotifen.", "severity": 2}
{"drug1": "buspirone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Retigabine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Fospropofol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with loxapine.", "severity": 2}
{"drug1": "loxapine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with clomipramine.", "severity": 2}
{"drug1": "codeine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with zopiclone.", "severity": 2}
{"drug1": "halothane", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with indapamide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Ramelteon.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with primidone.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with DEZOCINE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with tolazoline.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with baclofen.", "severity": 2}
{"drug1": "indapamide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with ethchlorvynol.", "severity": 2}
{"drug1": "nystatin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with nilvadipine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with mepivacaine.", "severity": 2}
{"drug1": "risperidone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with enflurane.", "severity": 2}
{"drug1": "Tramadol", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with zaleplon.", "severity": 2}
{"drug1": "etizolam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Retigabine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Flibanserin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Desloratadine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with trandolapril.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with benzocaine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with methylprednisolone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with vigabatrin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Ramelteon.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Efonidipine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Pitavastatin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with fludiazepam.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Metipranolol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with mefenamic acid.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with acetylcholine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with ethosuximide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with efavirenz.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with methyclothiazide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with paramethasone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with bupivacaine.", "severity": 2}
{"drug1": "pergolide", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with quinidine.", "severity": 2}
{"drug1": "trazodone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "pergolide", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with cocaine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with nitroglycerin.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with procarbazine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "butamben", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Ramelteon.", "severity": 2}
{"drug1": "HEROIN", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "malathion", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when malathion is combined with pilocarpine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with maprotiline.", "severity": 2}
{"drug1": "pergolide", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with resveratrol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with dantrolene.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Lumiracoxib.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Abemaciclib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with enflurane.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Levocetirizine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Olopatadine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Pipamperone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with buspirone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "midazolam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with maprotiline.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with chlorthalidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with mesoridazine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with METAXALONE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Risedronic acid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with paroxetine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with trandolapril.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with desipramine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with fluoxetine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with halcinonide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with baclofen.", "severity": 2}
{"drug1": "celecoxib", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with alclofenac.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with arsenic trioxide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclophosphamide is combined with atorvastatin.", "severity": 2}
{"drug1": "doxazosin", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Hexobarbital.", "severity": 2}
{"drug1": "topiramate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Levocetirizine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Melatonin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "PHENYLACETIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with PHENYLACETIC ACID.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with baclofen.", "severity": 2}
{"drug1": "Retigabine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with paroxetine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "morphine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "pimozide", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with flunarizine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with reserpine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with etizolam.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ethopropazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with ethopropazine.", "severity": 2}
{"drug1": "nylidrin", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nylidrin is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "Metixene", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Mirabegron.", "severity": 2}
{"drug1": "chloroquine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with diflorasone.", "severity": 2}
{"drug1": "cetirizine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with flunarizine.", "severity": 2}
{"drug1": "morphine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Pipotiazine.", "severity": 2}
{"drug1": "thiopental", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with dipivefrin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "gemcitabine", "drug2": "bleomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gemcitabine is combined with bleomycin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with metoclopramide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with baclofen.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with propofol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with flunisolide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with betamethasone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Lormetazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Oxetacaine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ritodrine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Etoricoxib.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with halcinonide.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Mometasone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with difluprednate.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with ramipril.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with acetazolamide.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Tapentadol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with resveratrol.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with lidocaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with doxepin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Thioproperazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with venlafaxine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nefazodone.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with isradipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with methadone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Pizotifen.", "severity": 2}
{"drug1": "minoxidil", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with quetiapine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Metipranolol.", "severity": 2}
{"drug1": "felodipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with METAXALONE.", "severity": 2}
{"drug1": "diazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with butalbital.", "severity": 2}
{"drug1": "brotizolam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with METAXALONE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with cyclothiazide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Dapagliflozin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with alclometasone.", "severity": 2}
{"drug1": "reserpine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with haloperidol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Olopatadine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with dichlorphenamide.", "severity": 2}
{"drug1": "buspirone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with trifluoperazine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Paliperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with triflupromazine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with topiramate.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Olopatadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with formestane.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Pefloxacin.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Tapentadol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with betamethasone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with chloramphenicol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with teniposide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with lansoprazole.", "severity": 2}
{"drug1": "oxazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with fexofenadine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Retigabine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with methadone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with acemetacin.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Tolcapone.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with dantrolene.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with sulpiride.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Nitroprusside.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with chlorothiazide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with levodopa.", "severity": 2}
{"drug1": "bumetanide", "drug2": "plicamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with plicamycin.", "severity": 2}
{"drug1": "methysergide", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with pilocarpine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with dibucaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "terconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Bretylium.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with dipyridamole.", "severity": 2}
{"drug1": "pentazocine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with triazolam.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with azelastine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Almotriptan.", "severity": 2}
{"drug1": "desipramine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Escitalopram.", "severity": 2}
{"drug1": "desipramine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "desipramine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with moclobemide.", "severity": 2}
{"drug1": "Benidipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with fluvastatin.", "severity": 2}
{"drug1": "Benidipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Etidocaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "diazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with formestane.", "severity": 2}
{"drug1": "gabapentin", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with DESFLURANE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Lornoxicam.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Desloratadine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with atorvastatin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with nortriptyline.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with amoxapine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with theobromine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Lurasidone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with edrophonium.", "severity": 2}
{"drug1": "meperidine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with cetirizine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Pipamperone.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with diltiazem.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with dexamethasone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with tetracaine.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Escitalopram.", "severity": 2}
{"drug1": "clozapine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with pentazocine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with thiamylal.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with trazodone.", "severity": 2}
{"drug1": "pancuronium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with oxymorphone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with clomipramine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with halothane.", "severity": 2}
{"drug1": "felodipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with losartan.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Teriflunomide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with trichlormethiazide.", "severity": 2}
{"drug1": "loratadine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Escitalopram.", "severity": 2}
{"drug1": "diazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "levorphanol", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with phenobarbital.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Efonidipine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with flunarizine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with SERATRODAST.", "severity": 2}
{"drug1": "captopril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Clevidipine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with sparfloxacin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Temsirolimus.", "severity": 2}
{"drug1": "thiopental", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Propoxycaine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Pramocaine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Prasugrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Prasugrel.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with quetiapine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nadolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with ZILEUTON.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with fexofenadine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with thiopental.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with ambenonium.", "severity": 2}
{"drug1": "thiothixene", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with METAXALONE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Paliperidone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with ethosuximide.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Amrinone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with DESONIDE.", "severity": 2}
{"drug1": "reserpine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "haloprogin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with bepridil.", "severity": 2}
{"drug1": "nabumetone", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with niflumic acid.", "severity": 2}
{"drug1": "clozapine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Paliperidone.", "severity": 2}
{"drug1": "imipramine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nilvadipine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Aceprometazine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "midazolam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with clidinium.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Nebivolol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with MOLINDONE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with paramethasone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with nadolol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "flumethasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with malathion.", "severity": 2}
{"drug1": "enflurane", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Milnacipran.", "severity": 2}
{"drug1": "indinavir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indinavir is combined with oxycodone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with chlorzoxazone.", "severity": 2}
{"drug1": "cocaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with scopolamine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Fospropofol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Retigabine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with Torasemide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "HEROIN", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "thiopental", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with methazolamide.", "severity": 2}
{"drug1": "felodipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with venlafaxine.", "severity": 2}
{"drug1": "carprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with paramethasone.", "severity": 2}
{"drug1": "Metixene", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with oxymorphone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with dibucaine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "tetracaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with metolazone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Lercanidipine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "estradiol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with estradiol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with prazosin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with manidipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with epirizole.", "severity": 2}
{"drug1": "teniposide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when teniposide is combined with clozapine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Aripiprazole.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Demecarium.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with baclofen.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with epirizole.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Butethal", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Pramocaine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with fenbufen.", "severity": 2}
{"drug1": "Butethal", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Propoxycaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with lithium ion.", "severity": 2}
{"drug1": "docetaxel", "drug2": "VERTEPORFIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with VERTEPORFIN.", "severity": 2}
{"drug1": "Perospirone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with desipramine.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with Clevidipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with enoxacin.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Lornoxicam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with lithium ion.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Butethal.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Levocetirizine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with alclometasone.", "severity": 2}
{"drug1": "clozapine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with vigabatrin.", "severity": 2}
{"drug1": "Luliconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Luliconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with etizolam.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with amisulpride.", "severity": 2}
{"drug1": "butorphanol", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with DESFLURANE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Olopatadine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with SERATRODAST.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Retigabine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with triamterene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with topiramate.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with equilin.", "severity": 2}
{"drug1": "linezolid", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Cyamemazine.", "severity": 2}
{"drug1": "pargyline", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with maprotiline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with clidinium.", "severity": 2}
{"drug1": "imipramine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with nitrendipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with Salmeterol.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Olopatadine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "irbesartan", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with floctafenine.", "severity": 2}
{"drug1": "meclizine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with desipramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with oxprenolol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with KETAZOLAM.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Clobetasone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with tizanidine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with prazepam.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with imipramine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with dantrolene.", "severity": 2}
{"drug1": "formestane", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with rivastigmine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Fluspirilene.", "severity": 2}
{"drug1": "triazolam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with nitrous oxide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "alprostadil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vardenafil is combined with alprostadil.", "severity": 2}
{"drug1": "formestane", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with physostigmine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with zaleplon.", "severity": 2}
{"drug1": "lorazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with amoxapine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Clobetasone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Clevidipine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Levocetirizine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with fludrocortisone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with dyclonine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "imipramine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with moclobemide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Tasimelteon.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Desloratadine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Fluspirilene.", "severity": 2}
{"drug1": "methysergide", "drug2": "Rilpivirine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Rilpivirine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Crizotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Crizotinib.", "severity": 2}
{"drug1": "clozapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with Ephedrine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with OLODATEROL.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with PROCATEROL.", "severity": 2}
{"drug1": "Micafungin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with nimodipine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with isoxsuprine.", "severity": 2}
{"drug1": "zotepine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with loratadine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Levetiracetam.", "severity": 2}
{"drug1": "zotepine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with imipramine.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gliquidone is combined with Carbocisteine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "TRIPTORELIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with TRIPTORELIN.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Tolcapone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Mephobarbital.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with amitriptyline.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with clidinium.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Iloperidone.", "severity": 2}
{"drug1": "prazosin", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Tolcapone.", "severity": 2}
{"drug1": "butalbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with amitriptyline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nevirapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nevirapine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Propoxycaine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with epirizole.", "severity": 2}
{"drug1": "loxapine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Fospropofol.", "severity": 2}
{"drug1": "methysergide", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with resveratrol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "nicotinamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with nicotinamide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Oxetacaine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Desloratadine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Ketobemidone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with mepivacaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with nifedipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Pomalidomide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with doxazosin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with AMILORIDE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with labetalol.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with hydromorphone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with scopolamine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Ziprasidone.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with doxepin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Phenelzine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with bepridil.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tetracycline.", "severity": 2}
{"drug1": "zotepine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Difenoxin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with isoflurane.", "severity": 2}
{"drug1": "fenbufen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Fluprednidene.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tretinoin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with clonazepam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with promethazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with lithium ion.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Melatonin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Echothiophate.", "severity": 2}
{"drug1": "tolmetin", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with salicylamide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with ketamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with losartan.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Halazepam.", "severity": 2}
{"drug1": "methysergide", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with cilostazol.", "severity": 2}
{"drug1": "carboplatin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carboplatin is combined with clozapine.", "severity": 2}
{"drug1": "losartan", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with fosinopril.", "severity": 2}
{"drug1": "olanzapine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with proparacaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "itraconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with itraconazole.", "severity": 2}
{"drug1": "codeine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Perospirone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Pipamperone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with meclizine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with triprolidine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with galanthamine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Pinaverium.", "severity": 2}
{"drug1": "lidocaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with methocarbamol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with salicylamide.", "severity": 2}
{"drug1": "terconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with nimesulide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with methazolamide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Eplerenone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Nelarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Nelarabine.", "severity": 2}
{"drug1": "aspirin", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with medrysone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with amcinonide.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with nimesulide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Cariprazine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "flurazepam", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with diazepam.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "amiodarone", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with apraclonidine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with halothane.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Telmisartan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with alprazolam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with oxycodone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with propoxyphene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Naloxegol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with buspirone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with thiamylal.", "severity": 2}
{"drug1": "benazepril", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "haloperidol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with meclizine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with furosemide.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with Clevidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with SERTINDOLE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "losartan", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with nitroglycerin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with salicylic acid.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Aceclofenac.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with zaltoprofen.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nadolol.", "severity": 2}
{"drug1": "diazepam", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with atorvastatin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with desipramine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with desipramine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with SERATRODAST.", "severity": 2}
{"drug1": "ketamine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with meclofenamic acid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with furosemide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with tizanidine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "cabergoline", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with haloperidol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Phenelzine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Dapagliflozin.", "severity": 2}
{"drug1": "codeine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with quazepam.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with zaltoprofen.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Riociguat.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with flunarizine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Riociguat.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with NITROUS ACID.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with formestane.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Lormetazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Elbasvir.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Oxetacaine.", "severity": 2}
{"drug1": "halothane", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with brotizolam.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Halobetasol.", "severity": 2}
{"drug1": "fenbufen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with sulfasalazine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "dyclonine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with propoxyphene.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with difluprednate.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with halcinonide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with doxepin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with MELPERONE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with promethazine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with clonazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with protriptyline.", "severity": 2}
{"drug1": "Normethadone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with promethazine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with clonazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with cetirizine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tioconazole.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with tiapride.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with trandolapril.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "triamterene", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with methazolamide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with fludrocortisone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Torasemide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "pramipexole", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with losartan.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with prochlorperazine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "meclizine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Iloperidone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with prochlorperazine.", "severity": 2}
{"drug1": "pancuronium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with hydromorphone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Ephedrine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with cinoxacin.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Hexobarbital.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Pramocaine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with VERAPAMIL.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Propoxycaine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Etidocaine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with loteprednol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Lurasidone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with oxprenolol.", "severity": 2}
{"drug1": "propofol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Perospirone.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Levetiracetam.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with diclofenac.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with efavirenz.", "severity": 2}
{"drug1": "tioconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with bepridil.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with lithium ion.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with tetracaine.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with lovastatin.", "severity": 2}
{"drug1": "quinapril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with acebutolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with GUANFACINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with maprotiline.", "severity": 2}
{"drug1": "azelastine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with aspirin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with loteprednol.", "severity": 2}
{"drug1": "prazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "labetalol", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with clenbuterol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Butethal.", "severity": 2}
{"drug1": "estazolam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with desipramine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Fospropofol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "estazolam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with thiamylal.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Propacetamol.", "severity": 2}
{"drug1": "enalapril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Clevidipine.", "severity": 2}
{"drug1": "estazolam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with halothane.", "severity": 2}
{"drug1": "Icatibant", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with halothane.", "severity": 2}
{"drug1": "Icatibant", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with paramethasone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Agomelatine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with vigabatrin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with halothane.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with mepivacaine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with propoxyphene.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "MEDROGESTONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with MEDROGESTONE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with meclizine.", "severity": 2}
{"drug1": "butalbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with methocarbamol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with oxymorphone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Lormetazepam.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with chloroquine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with mesoridazine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with procarbazine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with sulindac.", "severity": 2}
{"drug1": "barnidipine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with rasagiline.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Remoxipride.", "severity": 2}
{"drug1": "Metixene", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with propoxyphene.", "severity": 2}
{"drug1": "risperidone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with acetazolamide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with enalapril.", "severity": 2}
{"drug1": "Amrinone", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with pravastatin.", "severity": 2}
{"drug1": "halothane", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with terazosin.", "severity": 2}
{"drug1": "halothane", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with risperidone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with epirizole.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Iloperidone.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ergocalciferol is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with ibuprofen.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with bupropion.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "enalapril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with salicylamide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Eprosartan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with amitriptyline.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Tolcapone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with AMILORIDE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with carisoprodol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cerulenin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with eperisone.", "severity": 2}
{"drug1": "THYMOL", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with nilvadipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with mirtazapine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with amitriptyline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Tolcapone.", "severity": 2}
{"drug1": "indapamide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Eprosartan.", "severity": 2}
{"drug1": "gemcitabine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gemcitabine is combined with leflunomide.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with quetiapine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with tolazoline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with pilocarpine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with tizanidine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with felodipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "pimozide", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Perospirone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with budesonide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with clomipramine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Desloratadine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with isocarboxazid.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Flibanserin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with ketamine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Pizotifen.", "severity": 2}
{"drug1": "quinapril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with carprofen.", "severity": 2}
{"drug1": "meperidine", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with DESFLURANE.", "severity": 2}
{"drug1": "ramipril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Metipranolol.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with moclobemide.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when calcium lactate is combined with Calcifediol.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with ethotoin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with chloral hydrate.", "severity": 2}
{"drug1": "propofol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Oxetacaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with loteprednol.", "severity": 2}
{"drug1": "isradipine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Ketobemidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with thiamylal.", "severity": 2}
{"drug1": "meperidine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with citalopram.", "severity": 2}
{"drug1": "amobarbital", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with halothane.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with chlorothiazide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with bumetanide.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Icatibant.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Retigabine.", "severity": 2}
{"drug1": "pimozide", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with oxymorphone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with baclofen.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with clidinium.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Oxetacaine.", "severity": 2}
{"drug1": "pimozide", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with zopiclone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Panobinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Panobinostat.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with halothane.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with reserpine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with secobarbital.", "severity": 2}
{"drug1": "bromazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with thiamylal.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Remoxipride.", "severity": 2}
{"drug1": "bromazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with desipramine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Iloperidone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "bumetanide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Desloratadine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with paroxetine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with irbesartan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Eplerenone.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "oxazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with proparacaine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Halazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with ALFENTANIL.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Icatibant.", "severity": 2}
{"drug1": "temazepam", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Levobupivacaine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Clobetasone.", "severity": 2}
{"drug1": "isradipine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Flibanserin.", "severity": 2}
{"drug1": "isradipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with prilocaine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with imipramine.", "severity": 2}
{"drug1": "loxapine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "benazepril", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with clonidine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with bumetanide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with SERATRODAST.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with captopril.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with zaltoprofen.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Remoxipride.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Milnacipran.", "severity": 2}
{"drug1": "clozapine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Melatonin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with quinapril.", "severity": 2}
{"drug1": "enflurane", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with imipramine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with triamcinolone.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clenbuterol is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with flunisolide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with prochlorperazine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Pizotifen.", "severity": 2}
{"drug1": "enflurane", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with loratadine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "morphine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with dipyridamole.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with phenytoin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with oxymorphone.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Carbocisteine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with mesalamine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with felbamate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with furazolidone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with mepivacaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with zaleplon.", "severity": 2}
{"drug1": "butamben", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with desipramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with dibucaine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with metolazone.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "linezolid", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with perphenazine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Eplerenone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with methazolamide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with amitriptyline.", "severity": 2}
{"drug1": "selegiline", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with isoetharine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Tolcapone.", "severity": 2}
{"drug1": "loxapine", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with secobarbital.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Fluspirilene.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Tadalafil.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Articaine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with antipyrine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with diazepam.", "severity": 2}
{"drug1": "Nabilone", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with bumetanide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Loxoprofen.", "severity": 2}
{"drug1": "enflurane", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with chlormezanone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with reserpine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with clidinium.", "severity": 2}
{"drug1": "temazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with prilocaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with isoflurane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "terazosin", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Riociguat.", "severity": 2}
{"drug1": "temazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with ethotoin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with sevoflurane.", "severity": 2}
{"drug1": "nicergoline", "drug2": "sulfisoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with sulfisoxazole.", "severity": 2}
{"drug1": "scopolamine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with tubocurarine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "tobramycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with tobramycin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with mycophenolic acid.", "severity": 2}
{"drug1": "quazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Pomalidomide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with METAXALONE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Retigabine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Perampanel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Perampanel.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with mefloquine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with methazolamide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Eplerenone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with chlorprothixene.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with dibucaine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Oxetacaine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with estrone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with butamben.", "severity": 2}
{"drug1": "thioridazine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with triamterene.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with etodolac.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Canagliflozin.", "severity": 2}
{"drug1": "biperiden", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Ketobemidone.", "severity": 2}
{"drug1": "meclizine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Pizotifen.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with hydrocortisone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with simvastatin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with acemetacin.", "severity": 2}
{"drug1": "selegiline", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with brimonidine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with dyclonine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Normethadone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with propoxyphene.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Apremilast.", "severity": 2}
{"drug1": "selegiline", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with sotalol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with thiopental.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Apremilast.", "severity": 2}
{"drug1": "lithium ion", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with scopolamine.", "severity": 2}
{"drug1": "pergolide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with risperidone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with ethosuximide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with amoxapine.", "severity": 2}
{"drug1": "furosemide", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with streptozocin.", "severity": 2}
{"drug1": "pimozide", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with dyclonine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with nortriptyline.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with chloral hydrate.", "severity": 2}
{"drug1": "codeine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Masoprocol.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with ramipril.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "codeine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Eplerenone.", "severity": 2}
{"drug1": "codeine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with methazolamide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with oxymetholone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with dibucaine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with cilnidipine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Milnacipran.", "severity": 2}
{"drug1": "meprobamate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Propiverine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Fosphenytoin.", "severity": 2}
{"drug1": "cocaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Retigabine.", "severity": 2}
{"drug1": "topiramate", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with phenobarbital.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Agomelatine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with dexamethasone.", "severity": 2}
{"drug1": "midazolam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with scopolamine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Sacubitril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with prazepam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Olopatadine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with oxprenolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with nortriptyline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with amoxapine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with propranolol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with antipyrine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with nimodipine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with etizolam.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Sacubitril.", "severity": 2}
{"drug1": "butalbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with meclizine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with dextromethorphan.", "severity": 2}
{"drug1": "aspirin", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with dexamethasone.", "severity": 2}
{"drug1": "retinol", "drug2": "Alitretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when retinol is combined with Alitretinoin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Retigabine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with nadolol.", "severity": 2}
{"drug1": "propofol", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with triazolam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with celecoxib.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "biperiden", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with oxycodone.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Pizotifen.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "barnidipine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with oxprenolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Frovatriptan.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "EDTA", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with EDTA.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with ethchlorvynol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with nitrous oxide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with dorzolamide.", "severity": 2}
{"drug1": "propofol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with amcinonide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with haloperidol.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with butamben.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Levalbuterol.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with bepridil.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "minoxidil", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with metolazone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Ramelteon.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with chlorprothixene.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Temsirolimus.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Isavuconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Naftifine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Difenoxin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with thiamylal.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bivalirudin is combined with meperidine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ritodrine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with nabumetone.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with acetylcholine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with chlorprothixene.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with clomiphene.", "severity": 2}
{"drug1": "Benidipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with simvastatin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with levodopa.", "severity": 2}
{"drug1": "ketamine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with flunarizine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with nitric oxide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with flumethasone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with prednisone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with tubocurarine.", "severity": 2}
{"drug1": "Articaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with topiramate.", "severity": 2}
{"drug1": "quetiapine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with brotizolam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Olmesartan.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Aceclofenac.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with topiramate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with budesonide.", "severity": 2}
{"drug1": "brimonidine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with AMILORIDE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with procaine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with trimipramine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with doxepin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with lithium ion.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with trandolapril.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with floctafenine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with baclofen.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with topiramate.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Tasimelteon.", "severity": 2}
{"drug1": "amcinonide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with promethazine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Pefloxacin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "flumethasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with nimodipine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Cariprazine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with paramethasone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with losartan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with thioridazine.", "severity": 2}
{"drug1": "morphine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Tasimelteon.", "severity": 2}
{"drug1": "meprobamate", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with buspirone.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Desloratadine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with sevoflurane.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with quinapril.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with sumatriptan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "melphalan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with melphalan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with thalidomide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "methysergide", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nilvadipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with triamterene.", "severity": 2}
{"drug1": "methysergide", "drug2": "Fosaprepitant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Fosaprepitant.", "severity": 2}
{"drug1": "oxazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Aripiprazole.", "severity": 2}
{"drug1": "leflunomide", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with homoharringtonine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with levodopa.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Deferasirox.", "severity": 2}
{"drug1": "oxazepam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with sevoflurane.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with nadolol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "suprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with fludrocortisone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with clomipramine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with penbutolol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Clobetasone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Estrone sulfate.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Pinaverium.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with dantrolene.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with azelastine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Pramocaine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with niflumic acid.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "rasagiline", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with cabergoline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Eplerenone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with clozapine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with brotizolam.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with manidipine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Olsalazine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Normethadone.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Benidipine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with clidinium.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "imipramine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Salmeterol.", "severity": 2}
{"drug1": "memantine", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when memantine is combined with pilocarpine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Loxoprofen.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Tolcapone.", "severity": 2}
{"drug1": "imipramine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with maprotiline.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Droxicam.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with tolfenamic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with fluocinonide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Retigabine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Flibanserin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Cis-mdp.", "severity": 2}
{"drug1": "papaverine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with nadolol.", "severity": 2}
{"drug1": "propantheline", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with codeine.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Flibanserin.", "severity": 2}
{"drug1": "labetalol", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Ephedrine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with PROCATEROL.", "severity": 2}
{"drug1": "estazolam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with ethosuximide.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with Phenelzine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with nadolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Metipranolol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nifedipine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with Tolcapone.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with flunarizine.", "severity": 2}
{"drug1": "Amrinone", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Clevidipine.", "severity": 2}
{"drug1": "amifostine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with selegiline.", "severity": 2}
{"drug1": "clozapine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "meprobamate", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with secobarbital.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with suprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with loteprednol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Perospirone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Clevidipine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with levodopa.", "severity": 2}
{"drug1": "pancuronium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with pentazocine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "enalapril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Aliskiren.", "severity": 2}
{"drug1": "quazepam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with cetirizine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Demecarium.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Articaine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Levetiracetam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with GUANFACINE.", "severity": 2}
{"drug1": "carprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with SERTINDOLE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with ILOPROST.", "severity": 2}
{"drug1": "citalopram", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Lorcaserin.", "severity": 2}
{"drug1": "imipramine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with paroxetine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Clevidipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Propacetamol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Levomilnacipran.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Iloperidone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Fospropofol.", "severity": 2}
{"drug1": "labetalol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Pomalidomide.", "severity": 2}
{"drug1": "procaine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with tranylcypromine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with meperidine.", "severity": 2}
{"drug1": "procaine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with prilocaine.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with simvastatin.", "severity": 2}
{"drug1": "procaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with ethotoin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with phenytoin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Melatonin.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with citalopram.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Sacubitril.", "severity": 2}
{"drug1": "diclofenac", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with equilin.", "severity": 2}
{"drug1": "furosemide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with D-mannitol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with promethazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with reserpine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Aceprometazine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Droxicam.", "severity": 2}
{"drug1": "Butethal", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with clidinium.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with chlormezanone.", "severity": 2}
{"drug1": "diazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with prazepam.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Perospirone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with CLONIXIN.", "severity": 2}
{"drug1": "trazodone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with benzocaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ambroxol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ambroxol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with dibucaine.", "severity": 2}
{"drug1": "trazodone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with vigabatrin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with antipyrine.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Efonidipine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Clobetasone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Ramelteon.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Pomalidomide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ethosuximide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with benzyl alcohol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with AMILORIDE.", "severity": 2}
{"drug1": "primidone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with thiopental.", "severity": 2}
{"drug1": "propantheline", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with oxymorphone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with zonisamide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with brotizolam.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ZILEUTON.", "severity": 2}
{"drug1": "maprotiline", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with flunarizine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with tiagabine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Cariprazine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with sevoflurane.", "severity": 2}
{"drug1": "pentazocine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Clevidipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Eprosartan.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Tixocortol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with suprofen.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Icatibant.", "severity": 2}
{"drug1": "acebutolol", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with captopril.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with flunarizine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with etizolam.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with thalidomide.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with ondansetron.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with bumetanide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with chlorothiazide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with quinapril.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with flurazepam.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyzine is combined with duloxetine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Pizotifen.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with antipyrine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Escitalopram.", "severity": 2}
{"drug1": "risperidone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with procaine.", "severity": 2}
{"drug1": "zotepine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Levetiracetam.", "severity": 2}
{"drug1": "clonidine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with VERAPAMIL.", "severity": 2}
{"drug1": "practolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when practolol is combined with acetylcholine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Pimecrolimus.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "benazepril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with isoxsuprine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with amobarbital.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with rizatriptan.", "severity": 2}
{"drug1": "leflunomide", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with fluocinonide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Butethal.", "severity": 2}
{"drug1": "temazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Pipotiazine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with thiothixene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Hexobarbital.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with olanzapine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Etidocaine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with estazolam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with chlorprothixene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "trazodone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Mephobarbital.", "severity": 2}
{"drug1": "Nabilone", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with venlafaxine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Fospropofol.", "severity": 2}
{"drug1": "morphine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with sevoflurane.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with brotizolam.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Ramelteon.", "severity": 2}
{"drug1": "protriptyline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with formoterol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ticagrelor is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "protriptyline", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with fosinopril.", "severity": 2}
{"drug1": "trandolapril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with salicylamide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with brotizolam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with salicylamide.", "severity": 2}
{"drug1": "promazine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with primidone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with pilocarpine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Clevidipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with chlorothiazide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with flurandrenolide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with mecamylamine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with cetirizine.", "severity": 2}
{"drug1": "temazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with brotizolam.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Metixene.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with lithium ion.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with butamben.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with PROCATEROL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with baclofen.", "severity": 2}
{"drug1": "azelastine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with fludrocortisone.", "severity": 2}
{"drug1": "suprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with ESMOLOL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with flurazepam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with hydralazine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with oxprenolol.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Retigabine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with prazepam.", "severity": 2}
{"drug1": "terazosin", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with hydralazine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with cetirizine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Butylscopolamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with protriptyline.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Nebivolol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with tizanidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with pramipexole.", "severity": 2}
{"drug1": "ritodrine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Propiverine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with methscopolamine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with vigabatrin.", "severity": 2}
{"drug1": "enalapril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with isoxsuprine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with benzocaine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Droxicam.", "severity": 2}
{"drug1": "sulindac", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Zoledronic acid.", "severity": 2}
{"drug1": "promazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with maprotiline.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with meclizine.", "severity": 2}
{"drug1": "sulindac", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with quetiapine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Loxoprofen.", "severity": 2}
{"drug1": "temazepam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with quetiapine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Droxicam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with zonisamide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Ketobemidone.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with zonisamide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with betamethasone.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tamoxifen is combined with atorvastatin.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asunaprevir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with reserpine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Apremilast.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with tiagabine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with decamethonium.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with fenbufen.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Remoxipride.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with loxapine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nicardipine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Retigabine.", "severity": 2}
{"drug1": "propantheline", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Methadyl acetate.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Sacubitril.", "severity": 2}
{"drug1": "isoflurane", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with tolazoline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with meclizine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Clevidipine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with chlorpheniramine.", "severity": 2}
{"drug1": "procaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with fludiazepam.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with SERATRODAST.", "severity": 2}
{"drug1": "tiapride", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with imipramine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Tolcapone.", "severity": 2}
{"drug1": "tiapride", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with loratadine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Fospropofol.", "severity": 2}
{"drug1": "thiopental", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Etidocaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with gabapentin.", "severity": 2}
{"drug1": "temazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with enflurane.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with chloral hydrate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with flunisolide.", "severity": 2}
{"drug1": "triazolam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with paroxetine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ifosfamide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with tacrolimus.", "severity": 2}
{"drug1": "sulindac", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with meclofenamic acid.", "severity": 2}
{"drug1": "sulindac", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with salicylic acid.", "severity": 2}
{"drug1": "isoflurane", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with butalbital.", "severity": 2}
{"drug1": "etizolam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Tasimelteon.", "severity": 2}
{"drug1": "benztropine", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with propantheline.", "severity": 2}
{"drug1": "loxapine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with estazolam.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with nitrous oxide.", "severity": 2}
{"drug1": "triprolidine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with flunarizine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "pergolide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with trazodone.", "severity": 2}
{"drug1": "pergolide", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with ciprofloxacin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Flibanserin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with ethosuximide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with paramethasone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with paramethasone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with quetiapine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with thiopental.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with felbamate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with baclofen.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Calcifediol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glubionate calcium is combined with Calcifediol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Efonidipine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Retigabine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with clidinium.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with levorphanol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Bretylium.", "severity": 2}
{"drug1": "propofol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "sertraline", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with rasagiline.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with butalbital.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Mephobarbital.", "severity": 2}
{"drug1": "midazolam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with triflupromazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with lidocaine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Toloxatone.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with GUANFACINE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with Gemifloxacin.", "severity": 2}
{"drug1": "quinapril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with fenoprofen.", "severity": 2}
{"drug1": "sertraline", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with isocarboxazid.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with imipramine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with hydralazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with loratadine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with meperidine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NEOSTIGMINE is combined with acetylcholine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "methylene blue", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with methylene blue.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Olopatadine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Ziprasidone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with trimipramine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "chloroquine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with DESONIDE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Deferasirox.", "severity": 2}
{"drug1": "propantheline", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with meperidine.", "severity": 2}
{"drug1": "labetalol", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "leflunomide", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "ketamine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with efavirenz.", "severity": 2}
{"drug1": "estazolam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "oxycodone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with tiagabine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ondansetron.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with terbutaline.", "severity": 2}
{"drug1": "benzocaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with tiapride.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with HEROIN.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nifedipine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Riociguat.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with tiagabine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with triamterene.", "severity": 2}
{"drug1": "pentazocine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with halothane.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "diflunisal", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with zonisamide.", "severity": 2}
{"drug1": "baclofen", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Pomalidomide.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with antipyrine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Desloratadine.", "severity": 2}
{"drug1": "baclofen", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Levomilnacipran.", "severity": 2}
{"drug1": "valsartan", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Eprosartan.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with DEZOCINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Conivaptan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with lithium ion.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with scopolamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with cetirizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Lormetazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with protriptyline.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with Enalaprilat.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with flunisolide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "methotrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamethoxazole is combined with methotrexate.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with fosinopril.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with levodopa.", "severity": 2}
{"drug1": "amoxapine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with dantrolene.", "severity": 2}
{"drug1": "phenytoin", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with lithium ion.", "severity": 2}
{"drug1": "Icatibant", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with fenbufen.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with oxycodone.", "severity": 2}
{"drug1": "buspirone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with olanzapine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Olopatadine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rivaroxaban is combined with cyclophosphamide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with tizanidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with bromazepam.", "severity": 2}
{"drug1": "celiprolol", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with methylprednisolone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "temazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with temazepam.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with nalbuphine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Phenelzine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with scopolamine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with salicylic acid.", "severity": 2}
{"drug1": "aspirin", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with dibucaine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Fospropofol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Nepafenac.", "severity": 2}
{"drug1": "epirizole", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "quetiapine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with zonisamide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aminophylline is combined with Indacaterol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with loratadine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with tiagabine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with flurbiprofen.", "severity": 2}
{"drug1": "codeine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with METAXALONE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with phenytoin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with amisulpride.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Etidocaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Etomidate.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with donepezil.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Ropivacaine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with bupivacaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with zopiclone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with losartan.", "severity": 2}
{"drug1": "nabumetone", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with paroxetine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with nifedipine.", "severity": 2}
{"drug1": "propofol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with etizolam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with DESONIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with enoxacin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Isometheptene.", "severity": 2}
{"drug1": "benztropine", "drug2": "ipratropium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with ipratropium.", "severity": 2}
{"drug1": "quinidine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with nalbuphine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with etoposide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with amisulpride.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Aliskiren.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Eplerenone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Levocetirizine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Melatonin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Cis-mdp.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with promethazine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with clonazepam.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with apraclonidine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with flurandrenolide.", "severity": 2}
{"drug1": "meperidine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with quetiapine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Deferasirox.", "severity": 2}
{"drug1": "meperidine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ketamine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Pizotifen.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Agomelatine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Fospropofol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with droperidol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Empagliflozin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with azelastine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Difenoxin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with zopiclone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with carprofen.", "severity": 2}
{"drug1": "buspirone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with zotepine.", "severity": 2}
{"drug1": "buspirone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with MELPERONE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Bretylium.", "severity": 2}
{"drug1": "pimozide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with GUANFACINE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with bupivacaine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Ramelteon.", "severity": 2}
{"drug1": "gabapentin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with flunarizine.", "severity": 2}
{"drug1": "estazolam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "temazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with thalidomide.", "severity": 2}
{"drug1": "cetirizine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "captopril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with ADAPALENE.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with flunarizine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "secobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with secobarbital.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with metaproterenol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Ciclesonide.", "severity": 2}
{"drug1": "midazolam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with flunarizine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with dopamine.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with phenytoin.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with maprotiline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with paramethasone.", "severity": 2}
{"drug1": "methysergide", "drug2": "vincristine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with vincristine.", "severity": 2}
{"drug1": "losartan", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Nebivolol.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Clofarabine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Tixocortol.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with desipramine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with ouabain.", "severity": 2}
{"drug1": "morphine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with benazepril.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with methyldopa.", "severity": 2}
{"drug1": "morphine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nortriptyline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with benzocaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with mequitazine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Atazanavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Atazanavir.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with apraclonidine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "iopromide", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when iopromide is combined with metformin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with triflupromazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with pentazocine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with trazodone.", "severity": 2}
{"drug1": "methysergide", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with zafirlukast.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "quazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with trimipramine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with indomethacin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Olopatadine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Loxoprofen.", "severity": 2}
{"drug1": "celecoxib", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with halcinonide.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Clobetasone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with difluprednate.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Droxicam.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Ecabet", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Ecabet.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Gallium nitrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Gallium nitrate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with dexamethasone.", "severity": 2}
{"drug1": "diazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with brotizolam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with sertraline.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Metipranolol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Pizotifen.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Articaine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with irbesartan.", "severity": 2}
{"drug1": "indomethacin", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with desoximetasone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with carisoprodol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with felodipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Paliperidone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with sevoflurane.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Aripiprazole.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "thiopental", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with flunarizine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with formestane.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with rivastigmine.", "severity": 2}
{"drug1": "imipramine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Pizotifen.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with ethotoin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with carisoprodol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with prilocaine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with chlorothiazide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with tranylcypromine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Tasimelteon.", "severity": 2}
{"drug1": "tretinoin", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with trandolapril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with SUFENTANIL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with methazolamide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Eplerenone.", "severity": 2}
{"drug1": "triprolidine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with PROCATEROL.", "severity": 2}
{"drug1": "butalbital", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Flibanserin.", "severity": 2}
{"drug1": "Articaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with baclofen.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with maprotiline.", "severity": 2}
{"drug1": "propantheline", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with quinidine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with mesoridazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rivaroxaban is combined with Nintedanib.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Pomalidomide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with trifluoperazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with prochlorperazine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with tiapride.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with nitric oxide.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with nalbuphine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with niflumic acid.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Pomalidomide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with carvedilol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "goserelin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with goserelin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Demecarium.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Pomalidomide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with dantrolene.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with imipramine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Eprosartan.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with loratadine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with estazolam.", "severity": 2}
{"drug1": "procaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Levobupivacaine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with medrysone.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Naftifine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with norfloxacin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with tiagabine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with cocaine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with cinoxacin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Retigabine.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with simvastatin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Tapentadol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with zonisamide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with nadolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with resveratrol.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with duloxetine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with zaltoprofen.", "severity": 2}
{"drug1": "methysergide", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Tramadol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with butamben.", "severity": 2}
{"drug1": "methysergide", "drug2": "erythromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with erythromycin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with tetracaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with cyclothiazide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with flurandrenolide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with chlorprothixene.", "severity": 2}
{"drug1": "buspirone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Tolcapone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with captopril.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with Pitavastatin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Aliskiren.", "severity": 2}
{"drug1": "cilazapril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "miconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with eperisone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Pipamperone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with tetracaine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with fexofenadine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Almotriptan.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Fosamprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Fosamprenavir.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with bifonazole.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with indapamide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with methadone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with tranylcypromine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Pipamperone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with fenoldopam.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritonavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with fosinopril.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with dantrolene.", "severity": 2}
{"drug1": "prazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Flibanserin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Escitalopram.", "severity": 2}
{"drug1": "gabapentin", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with sevoflurane.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with clomipramine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with terazosin.", "severity": 2}
{"drug1": "butalbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with METAXALONE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with spironolactone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with butalbital.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with efavirenz.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Difenoxin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Levetiracetam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with cilnidipine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Efonidipine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Lacidipine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Fospropofol.", "severity": 2}
{"drug1": "midazolam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with DEZOCINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "meprobamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with meprobamate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with tubocurarine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with diflunisal.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Lumiracoxib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with edrophonium.", "severity": 2}
{"drug1": "diflunisal", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with estrone.", "severity": 2}
{"drug1": "labetalol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Aliskiren.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Nitroprusside.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with fluocinonide.", "severity": 2}
{"drug1": "benazepril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Empagliflozin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with butamben.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with dipyridamole.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with methyclothiazide.", "severity": 2}
{"drug1": "clonidine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with apraclonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Desloratadine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Telmisartan.", "severity": 2}
{"drug1": "methysergide", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with betamethasone.", "severity": 2}
{"drug1": "methysergide", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with chloramphenicol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with metolazone.", "severity": 2}
{"drug1": "methysergide", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with teniposide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with scopolamine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Fosamprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Fosamprenavir.", "severity": 2}
{"drug1": "bromazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with tiapride.", "severity": 2}
{"drug1": "flurazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with loratadine.", "severity": 2}
{"drug1": "sulindac", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "barnidipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with acebutolol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with mesoridazine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with imipramine.", "severity": 2}
{"drug1": "carprofen", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with fenbufen.", "severity": 2}
{"drug1": "prilocaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with maprotiline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with rivastigmine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with vigabatrin.", "severity": 2}
{"drug1": "tolazoline", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with spironolactone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with cetirizine.", "severity": 2}
{"drug1": "methysergide", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Zucapsaicin.", "severity": 2}
{"drug1": "Quinine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Quinine is combined with prilocaine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with paroxetine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "barnidipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with captopril.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with hydrocortisone.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with ZILEUTON.", "severity": 2}
{"drug1": "promethazine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Melatonin.", "severity": 2}
{"drug1": "Articaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with cyclothiazide.", "severity": 2}
{"drug1": "morphine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with vigabatrin.", "severity": 2}
{"drug1": "morphine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Tasimelteon.", "severity": 2}
{"drug1": "morphine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with benzocaine.", "severity": 2}
{"drug1": "promazine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Levocetirizine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with MELPERONE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with zotepine.", "severity": 2}
{"drug1": "cocaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with chlorprothixene.", "severity": 2}
{"drug1": "tiapride", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with tizanidine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with moclobemide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with PAMABROM.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "mesalamine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "apomorphine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with isocarboxazid.", "severity": 2}
{"drug1": "azelastine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with clonazepam.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with nifedipine.", "severity": 2}
{"drug1": "azelastine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with fenbufen.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with miconazole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with promethazine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with aspirin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with hydralazine.", "severity": 2}
{"drug1": "cocaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with amisulpride.", "severity": 2}
{"drug1": "minoxidil", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with timolol.", "severity": 2}
{"drug1": "butalbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with flunarizine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with methyldopa.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Hexobarbital.", "severity": 2}
{"drug1": "ramipril", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "enalapril", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with furosemide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with vigabatrin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with theobromine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with ethanol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with METAXALONE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Mometasone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosphenytoin is combined with paroxetine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Loxoprofen.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Droxicam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with tolfenamic acid.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Pizotifen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with CLONIXIN.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Fospropofol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with flunarizine.", "severity": 2}
{"drug1": "ethanol", "drug2": "phendimetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with phendimetrazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with amisulpride.", "severity": 2}
{"drug1": "etizolam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with efavirenz.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Pipotiazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Phenelzine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with prilocaine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Fluspirilene.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with docetaxel.", "severity": 2}
{"drug1": "thalidomide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with methyldopa.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with labetalol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with phenytoin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Alvimopan.", "severity": 2}
{"drug1": "paramethasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Telmisartan.", "severity": 2}
{"drug1": "thalidomide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with apraclonidine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Clodronic Acid.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Ketobemidone.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Masoprocol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with halothane.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with vigabatrin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with thiamylal.", "severity": 2}
{"drug1": "Etomidate", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with methoxyflurane.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with nitrazepam.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with Pitavastatin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Fospropofol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with oxprenolol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with clonazepam.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with Milnacipran.", "severity": 2}
{"drug1": "procaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with amoxapine.", "severity": 2}
{"drug1": "procaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with nortriptyline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with quazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with vinblastine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with benzocaine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with flunisolide.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with sertraline.", "severity": 2}
{"drug1": "proparacaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with vigabatrin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with resveratrol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with methyclothiazide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with medrysone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Salsalate.", "severity": 2}
{"drug1": "Tramadol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Pizotifen.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with hydralazine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Escitalopram.", "severity": 2}
{"drug1": "buspirone", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with flurazepam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Clobetasone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with MELPERONE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with enalapril.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with hydralazine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with pyridostigmine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with nicotine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Cevimeline.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with valsartan.", "severity": 2}
{"drug1": "loxapine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with mesoridazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ramipril.", "severity": 2}
{"drug1": "methoxamine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "methoxamine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with Ephedrine.", "severity": 2}
{"drug1": "loxapine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with maprotiline.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with tolterodine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "dopamine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with Ephedrine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "dopamine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with PROCATEROL.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with edrophonium.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Loxoprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with tolfenamic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Droxicam.", "severity": 2}
{"drug1": "salicylamide", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with formestane.", "severity": 2}
{"drug1": "tizanidine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with clidinium.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with CLONIXIN.", "severity": 2}
{"drug1": "thiothixene", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with triprolidine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with nefazodone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with salicylamide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with lidocaine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with doxepin.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when physostigmine is combined with Varenicline.", "severity": 2}
{"drug1": "oxycodone", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with pentazocine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with ESMOLOL.", "severity": 2}
{"drug1": "salicylamide", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with estrone.", "severity": 2}
{"drug1": "propranolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with levorphanol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ketorolac.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with nabumetone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Aceprometazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with MOLINDONE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with doxepin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with tenoxicam.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Propacetamol.", "severity": 2}
{"drug1": "methysergide", "drug2": "Dronedarone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Dronedarone.", "severity": 2}
{"drug1": "propofol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with chlormezanone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with fosinopril.", "severity": 2}
{"drug1": "betamethasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with norfloxacin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with dichlorphenamide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with levodopa.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Echothiophate.", "severity": 2}
{"drug1": "propofol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "morphine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with tetracaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with glutethimide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with flunarizine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with clemastine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with oxymorphone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with betamethasone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with brotizolam.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with desoximetasone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with phentolamine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with methocarbamol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with triprolidine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with chlorzoxazone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with furosemide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with zotepine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with MELPERONE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with hydromorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with trazodone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with maprotiline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with ifosfamide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with acebutolol.", "severity": 2}
{"drug1": "Amrinone", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with captopril.", "severity": 2}
{"drug1": "valsartan", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with DESONIDE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with clidinium.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Levocetirizine.", "severity": 2}
{"drug1": "valsartan", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with sulfasalazine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with clomipramine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Masoprocol.", "severity": 2}
{"drug1": "mechlorethamine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mechlorethamine is combined with clozapine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with methocarbamol.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with triprolidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with hydralazine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Loxoprofen.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Teriflunomide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Metixene.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with ritodrine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with topiramate.", "severity": 2}
{"drug1": "floctafenine", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with tolmetin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with rizatriptan.", "severity": 2}
{"drug1": "floctafenine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with haloperidol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Milnacipran.", "severity": 2}
{"drug1": "captopril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with triamcinolone.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with nimodipine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "halothane", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with bumetanide.", "severity": 2}
{"drug1": "selegiline", "drug2": "droxidopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with droxidopa.", "severity": 2}
{"drug1": "halothane", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "halothane", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with quinapril.", "severity": 2}
{"drug1": "halothane", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with chlorothiazide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with nimesulide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with dipyridamole.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with MELPERONE.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with salicylic acid.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with orphenadrine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RUCAPARIB is combined with Flibanserin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with terbutaline.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with CLONIXIN.", "severity": 2}
{"drug1": "bromazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with prazepam.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Thioproperazine is combined with thiopental.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "chlorambucil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with chlorambucil.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "bleomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with bleomycin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Halobetasol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with citalopram.", "severity": 2}
{"drug1": "bromazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "salicylamide", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "naratriptan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with bromocriptine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Milnacipran.", "severity": 2}
{"drug1": "methysergide", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with felodipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with bromocriptine.", "severity": 2}
{"drug1": "ramipril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with salicylamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with topiramate.", "severity": 2}
{"drug1": "temazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with glutethimide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with pramipexole.", "severity": 2}
{"drug1": "nimesulide", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with isoflurane.", "severity": 2}
{"drug1": "glutethimide", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with clidinium.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Elbasvir.", "severity": 2}
{"drug1": "betaxolol", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with atenolol.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with manidipine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Efonidipine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Iloperidone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Milnacipran.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Benidipine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Aceprometazine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with cilnidipine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with loteprednol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "temazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with dibucaine.", "severity": 2}
{"drug1": "propantheline", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Teriflunomide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with carprofen.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with quetiapine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with clonazepam.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with promethazine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with furosemide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with sumatriptan.", "severity": 2}
{"drug1": "valsartan", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with papaverine.", "severity": 2}
{"drug1": "valsartan", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with nifedipine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with brotizolam.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Fencamfamin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Retigabine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with bromocriptine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Halazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with meclizine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with labetalol.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Flibanserin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Milnacipran.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Ethylmorphine.", "severity": 2}
{"drug1": "pergolide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with norfloxacin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Teriflunomide.", "severity": 2}
{"drug1": "promazine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with chloral hydrate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with tiagabine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with cocaine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with zonisamide.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with flunarizine.", "severity": 2}
{"drug1": "pergolide", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with nitrendipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with zopiclone.", "severity": 2}
{"drug1": "epinephrine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with isoproterenol.", "severity": 2}
{"drug1": "captopril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with cilazapril.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with norfloxacin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with Echothiophate.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with acebutolol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with oxymorphone.", "severity": 2}
{"drug1": "etizolam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with nortriptyline.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with captopril.", "severity": 2}
{"drug1": "etizolam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with amoxapine.", "severity": 2}
{"drug1": "temazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with physostigmine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with pyridostigmine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with bifonazole.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with periciazine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with rivastigmine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with tizanidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with clidinium.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with medrysone.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with Amrinone.", "severity": 2}
{"drug1": "azelastine", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "butorphanol", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with tranylcypromine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nitric oxide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with tetracaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with MOLINDONE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "procaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with mesoridazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with prazepam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with MOLINDONE.", "severity": 2}
{"drug1": "procaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with maprotiline.", "severity": 2}
{"drug1": "chloroquine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with resveratrol.", "severity": 2}
{"drug1": "citalopram", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with selegiline.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Aceprometazine.", "severity": 2}
{"drug1": "ramipril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ramipril", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "ramipril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with sulfasalazine.", "severity": 2}
{"drug1": "midazolam", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with ambenonium.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with potassium ion.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Levalbuterol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with nitrous oxide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with acetylcholine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with sotalol.", "severity": 2}
{"drug1": "triazolam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with triflupromazine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Halazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with promethazine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with chloral hydrate.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Melatonin.", "severity": 2}
{"drug1": "enflurane", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with amisulpride.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with fludiazepam.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Lercanidipine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with isoxsuprine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Olopatadine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Indacaterol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with diflorasone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Fluprednidene.", "severity": 2}
{"drug1": "propofol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Eplerenone.", "severity": 2}
{"drug1": "propofol", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with polythiazide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Ruxolitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Ruxolitinib.", "severity": 2}
{"drug1": "tropicamide", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with methscopolamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with loratadine.", "severity": 2}
{"drug1": "ramipril", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with topiramate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with thiamylal.", "severity": 2}
{"drug1": "risperidone", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with mesoridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Halazepam.", "severity": 2}
{"drug1": "risperidone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with maprotiline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Lorcaserin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Normethadone.", "severity": 2}
{"drug1": "halothane", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with HEROIN.", "severity": 2}
{"drug1": "diazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Alvimopan.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with betamethasone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "morphine", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Tolvaptan.", "severity": 2}
{"drug1": "sulconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with nifedipine.", "severity": 2}
{"drug1": "morphine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Asenapine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with clonidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ethchlorvynol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Pipamperone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with edrophonium.", "severity": 2}
{"drug1": "flurazepam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with amobarbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with baclofen.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Hexobarbital.", "severity": 2}
{"drug1": "timolol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with metolazone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with lithium ion.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Etidocaine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with fenbufen.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with nefazodone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with benzocaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with vigabatrin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Retigabine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with METAXALONE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with maprotiline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with mesoridazine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "ramipril", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with spironolactone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with felbamate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with D-mannitol.", "severity": 2}
{"drug1": "trazodone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "diazepam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with maprotiline.", "severity": 2}
{"drug1": "carprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Risedronic acid.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with furazolidone.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with quetiapine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with acetazolamide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with propofol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with topiramate.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with losartan.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with carvedilol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with oxprenolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with procaine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with nicotine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Cevimeline.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Mometasone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Tramadol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with prazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with meclizine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with GUANFACINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with propofol.", "severity": 2}
{"drug1": "reserpine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with suprofen.", "severity": 2}
{"drug1": "reserpine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with enalapril.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with periciazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with fenbufen.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with morphine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with bumetanide.", "severity": 2}
{"drug1": "etodolac", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with difluprednate.", "severity": 2}
{"drug1": "thiopental", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with meclizine.", "severity": 2}
{"drug1": "etodolac", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with halcinonide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "SULFADOXINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with SULFADOXINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfacytine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfacytine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Olopatadine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with AMILORIDE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with atenolol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with clomipramine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with NITROUS ACID.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Flibanserin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with ethosuximide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with halothane.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Calcium acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with Calcium acetate.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Isometheptene.", "severity": 2}
{"drug1": "clozapine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Canagliflozin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with thiamylal.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ruxolitinib is combined with clozapine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Pramocaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Propoxycaine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Riociguat.", "severity": 2}
{"drug1": "prazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with levorphanol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "alprazolam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with baclofen.", "severity": 2}
{"drug1": "barnidipine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with reserpine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "diazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "meperidine", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with PAMABROM.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Methadyl acetate.", "severity": 2}
{"drug1": "ritonavir", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritonavir is combined with metronidazole.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with carprofen.", "severity": 2}
{"drug1": "Torasemide", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with spironolactone.", "severity": 2}
{"drug1": "desipramine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with isoetharine.", "severity": 2}
{"drug1": "felbamate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Pizotifen.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with nadolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with streptozocin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "propranolol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with lisinopril.", "severity": 2}
{"drug1": "buspirone", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "triamterene", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with furosemide.", "severity": 2}
{"drug1": "paroxetine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with amitriptyline.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with methocarbamol.", "severity": 2}
{"drug1": "midodrine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with benzphetamine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Naftifine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Propoxycaine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with periciazine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "prazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Articaine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with antipyrine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with metolazone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with amisulpride.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "butamben", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "thiopental", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Fencamfamin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with triamterene.", "severity": 2}
{"drug1": "thiopental", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Ethylmorphine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Mephobarbital.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with clonazepam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with promethazine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Pomalidomide.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with droperidol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with metolazone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Melatonin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Lumiracoxib.", "severity": 2}
{"drug1": "clozapine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with zopiclone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with olanzapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with acebutolol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Olopatadine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Normethadone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Clobetasone.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Etoricoxib.", "severity": 2}
{"drug1": "etodolac", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Aceclofenac.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with prilocaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Butethal.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Perospirone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Hexobarbital.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with propoxyphene.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Pipotiazine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with thiothixene.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lopinavir is combined with oxycodone.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with nimesulide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with hydralazine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Agomelatine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "etoposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with etoposide.", "severity": 2}
{"drug1": "baclofen", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "selegiline", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaliplatin is combined with clozapine.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with butorphanol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with etizolam.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with doxepin.", "severity": 2}
{"drug1": "selegiline", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with sulpiride.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with topiramate.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Perospirone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with formestane.", "severity": 2}
{"drug1": "primidone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Hexobarbital.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ZILEUTON.", "severity": 2}
{"drug1": "primidone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with amobarbital.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with fexofenadine.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "zidovudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with zidovudine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Olopatadine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with desipramine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with halothane.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with butamben.", "severity": 2}
{"drug1": "furosemide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with digitoxin.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with barnidipine.", "severity": 2}
{"drug1": "zotepine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with papaverine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with nimesulide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "irbesartan", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with niflumic acid.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with morphine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Ropivacaine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "lithium ion", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with baclofen.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Difenoxin.", "severity": 2}
{"drug1": "furosemide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Masoprocol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Belinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Belinostat.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with sulpiride.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with citalopram.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Rotigotine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with flunarizine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Levomepromazine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with donepezil.", "severity": 2}
{"drug1": "theophylline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when theophylline is combined with Indacaterol.", "severity": 2}
{"drug1": "enflurane", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Oxetacaine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Fluprednidene.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with clonazepam.", "severity": 2}
{"drug1": "meprobamate", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with methoxyflurane.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Olopatadine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with D-mannitol.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with nicardipine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "rapamycin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with isradipine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Pazopanib.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Difenoxin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Difenoxin.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with flunitrazepam.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "pimozide", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with fexofenadine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "warfarin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with warfarin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with propranolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with penbutolol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with clonidine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with oxprenolol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with fexofenadine.", "severity": 2}
{"drug1": "methadone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with triprolidine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Nebivolol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with KETAZOLAM.", "severity": 2}
{"drug1": "lithium ion", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with prazepam.", "severity": 2}
{"drug1": "promazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with clonazepam.", "severity": 2}
{"drug1": "irbesartan", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "morphine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Pizotifen.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Pipamperone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with loratadine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with orphenadrine.", "severity": 2}
{"drug1": "methadone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with MOLINDONE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with imipramine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with scopolamine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with Gemifloxacin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with D-mannitol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Bretylium.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvastatin is combined with atorvastatin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with physostigmine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with dyclonine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with droperidol.", "severity": 2}
{"drug1": "cocaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Pizotifen.", "severity": 2}
{"drug1": "paramethasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with rivastigmine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Olopatadine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with aspirin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with captopril.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with clozapine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with acebutolol.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with ethosuximide.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with metoprolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with meperidine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with medrysone.", "severity": 2}
{"drug1": "diazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with imipramine.", "severity": 2}
{"drug1": "diazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with loratadine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with apraclonidine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Clofarabine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Telmisartan.", "severity": 2}
{"drug1": "sulpiride", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with dantrolene.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with epirizole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with methyldopa.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Desloratadine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "paramethasone", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with galanthamine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with Isoflurophate.", "severity": 2}
{"drug1": "irbesartan", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with atorvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with ranitidine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tacrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with tacrolimus.", "severity": 2}
{"drug1": "clemastine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with methocarbamol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Levocetirizine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with felodipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with cyclothiazide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with quetiapine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with citalopram.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Lormetazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with bromazepam.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with dipyridamole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Pramocaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Propoxycaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with irinotecan.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Agomelatine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with meperidine.", "severity": 2}
{"drug1": "trazodone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "aspirin", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Propacetamol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with dantrolene.", "severity": 2}
{"drug1": "estrone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with enflurane.", "severity": 2}
{"drug1": "lidocaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Melatonin", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with protriptyline.", "severity": 2}
{"drug1": "Melatonin", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with cetirizine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with ethosuximide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "diltiazem", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with indapamide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with hydralazine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with HEROIN.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with cetirizine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with protriptyline.", "severity": 2}
{"drug1": "nabumetone", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with betamethasone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Eplerenone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with pimozide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Phenelzine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with lidocaine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with sertraline.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with tizanidine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with furosemide.", "severity": 2}
{"drug1": "sulindac", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with formestane.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with clidinium.", "severity": 2}
{"drug1": "sulindac", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "iopamidol", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when iopamidol is combined with metformin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with duloxetine.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with fluoxetine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "naratriptan", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with promazine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with anastrozole.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with fluvastatin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with medrysone.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with Canagliflozin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with benazepril.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with baclofen.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with levodopa.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with sevoflurane.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with chlorprothixene.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Aripiprazole.", "severity": 2}
{"drug1": "prednisone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with Demecarium.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Fosphenytoin.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with ethosuximide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with NICORANDIL.", "severity": 2}
{"drug1": "cetirizine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with thioridazine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Retigabine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with bromocriptine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with Pitavastatin.", "severity": 2}
{"drug1": "butalbital", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with GUANFACINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with salicylamide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with alclofenac.", "severity": 2}
{"drug1": "sulindac", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Ciclesonide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with rasagiline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with aspirin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Iloperidone.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with methazolamide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium acetate is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Metipranolol.", "severity": 2}
{"drug1": "fenbufen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with leflunomide.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with doxepin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Perospirone.", "severity": 2}
{"drug1": "citalopram", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with chlorprothixene.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Rotigotine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with nimodipine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with zaleplon.", "severity": 2}
{"drug1": "morphine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with hydralazine.", "severity": 2}
{"drug1": "busulfan", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when busulfan is combined with leflunomide.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with ethotoin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with methyclothiazide.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asunaprevir is combined with Temsirolimus.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with prazepam.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Levetiracetam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with primidone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Mometasone.", "severity": 2}
{"drug1": "papaverine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with nifedipine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Aripiprazole.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with flunisolide.", "severity": 2}
{"drug1": "proparacaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with phenytoin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with cocaine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dorzolamide is combined with metformin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with Tramadol.", "severity": 2}
{"drug1": "miconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with diflunisal.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with fenbufen.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with fludrocortisone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Tixocortol.", "severity": 2}
{"drug1": "cilazapril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with flurbiprofen.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "josamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with josamycin.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Milnacipran.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with nylidrin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with methazolamide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Eplerenone.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinic acid is combined with pravastatin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with rasagiline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Aceprometazine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with dipyridamole.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with mefloquine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with MOLINDONE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with pargyline.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Etomidate.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with losartan.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Ropivacaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with bupivacaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with halcinonide.", "severity": 2}
{"drug1": "metolazone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with methazolamide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with GUANFACINE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with hydromorphone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with clomipramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with lithium ion.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Lumiracoxib.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Carbamylcholine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with fludrocortisone.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with sertraline.", "severity": 2}
{"drug1": "Nabilone", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with irbesartan.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with methocarbamol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with methylphenidate.", "severity": 2}
{"drug1": "hydralazine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with cilazapril.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with triprolidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Pipotiazine.", "severity": 2}
{"drug1": "procaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with METAXALONE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Nepafenac.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Olopatadine.", "severity": 2}
{"drug1": "bepridil", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with AMILORIDE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pazopanib is combined with atorvastatin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Pizotifen.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Escitalopram.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with moclobemide.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with DEZOCINE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with thiothixene.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with SUFENTANIL.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with trandolapril.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with methazolamide.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with triprolidine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Eplerenone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "proparacaine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with dantrolene.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nitrous oxide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Propacetamol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Nitroprusside.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with tizanidine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with furosemide.", "severity": 2}
{"drug1": "droperidol", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when droperidol is combined with methylphenidate.", "severity": 2}
{"drug1": "quetiapine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with clidinium.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with promethazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with lidocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with clonazepam.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with fluocinonide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Cis-mdp.", "severity": 2}
{"drug1": "dibucaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with ethotoin.", "severity": 2}
{"drug1": "butamben", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with amoxapine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with prilocaine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "timolol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with AMILORIDE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Etoricoxib.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with amitriptyline.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with citalopram.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Tolcapone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Nitroprusside.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with reserpine.", "severity": 2}
{"drug1": "meperidine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with triflupromazine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Tasimelteon.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Perospirone.", "severity": 2}
{"drug1": "procyclidine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with oxybutynin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with maprotiline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "baclofen", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with doxepin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "doxazosin", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with isoetharine.", "severity": 2}
{"drug1": "propofol", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with GUANFACINE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with naratriptan.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with aspirin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with edrophonium.", "severity": 2}
{"drug1": "captopril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Pirlindole.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Toloxatone.", "severity": 2}
{"drug1": "promazine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Lurasidone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Phenelzine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with HYDROCODONE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with naratriptan.", "severity": 2}
{"drug1": "reserpine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with MOLINDONE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with salicylamide.", "severity": 2}
{"drug1": "losartan", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with chlorothiazide.", "severity": 2}
{"drug1": "losartan", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with quinapril.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Tramadol.", "severity": 2}
{"drug1": "losartan", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "losartan", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with bumetanide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with protriptyline.", "severity": 2}
{"drug1": "prilocaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with carisoprodol.", "severity": 2}
{"drug1": "pentazocine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with flunarizine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Fluspirilene.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with papaverine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with nifedipine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Pregabalin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Levetiracetam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with felbamate.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Clevidipine.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with Lercanidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with DEZOCINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Remoxipride.", "severity": 2}
{"drug1": "brotizolam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with maprotiline.", "severity": 2}
{"drug1": "reserpine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Aceprometazine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with nimesulide.", "severity": 2}
{"drug1": "etodolac", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with oxaprozin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with D-mannitol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with DESONIDE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Paliperidone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with brotizolam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with cinoxacin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Canrenoic acid.", "severity": 2}
{"drug1": "pentazocine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with furosemide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with nortriptyline.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with desipramine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with zaltoprofen.", "severity": 2}
{"drug1": "Artemether", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with cinnarizine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with triflupromazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Difenoxin.", "severity": 2}
{"drug1": "quinidine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Metixene.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with furosemide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Ramelteon.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with tizanidine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "meclizine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with paramethasone.", "severity": 2}
{"drug1": "halothane", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Ramelteon.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with resveratrol.", "severity": 2}
{"drug1": "suprofen", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with aspirin.", "severity": 2}
{"drug1": "halothane", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenofibrate is combined with simvastatin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyphylline is combined with OLODATEROL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with terazosin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with amisulpride.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with clonidine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Lornoxicam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with nalbuphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with brotizolam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with oxazepam.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Levocetirizine.", "severity": 2}
{"drug1": "temazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "temazepam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "temazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with benzocaine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with flurbiprofen.", "severity": 2}
{"drug1": "zotepine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Pipotiazine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with carvedilol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "pentostatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with pentostatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with quazepam.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with nimodipine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with cilazapril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with prazepam.", "severity": 2}
{"drug1": "temazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "brotizolam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "benazepril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Etoricoxib.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "cetirizine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with protriptyline.", "severity": 2}
{"drug1": "antipyrine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with nimesulide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with chloroquine.", "severity": 2}
{"drug1": "codeine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with procarbazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "codeine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with GUANFACINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Iloperidone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with METAXALONE.", "severity": 2}
{"drug1": "pergolide", "drug2": "docetaxel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with docetaxel.", "severity": 2}
{"drug1": "selegiline", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with loxapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Remoxipride.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Tramadol.", "severity": 2}
{"drug1": "pergolide", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with gemfibrozil.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with butalbital.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with sulpiride.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with digoxin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with levodopa.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Lormetazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "sulindac", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Limaprost", "drug2": "argatroban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with argatroban.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "midazolam", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Flupentixol.", "severity": 2}
{"drug1": "malathion", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when malathion is combined with Varenicline.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Pomalidomide.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with tetracaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Ziprasidone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with butalbital.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with phenytoin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with zopiclone.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Levocetirizine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "butenafine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with nimesulide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with CLONIXIN.", "severity": 2}
{"drug1": "Salsalate", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with fluocinonide.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with butamben.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with enalapril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with tiapride.", "severity": 2}
{"drug1": "meprobamate", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with brotizolam.", "severity": 2}
{"drug1": "loxapine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Icatibant.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with homoharringtonine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with azelastine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with brotizolam.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with promethazine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with ESMOLOL.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "estazolam", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with lithium ion.", "severity": 2}
{"drug1": "estazolam", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Hexobarbital.", "severity": 2}
{"drug1": "estazolam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Butethal.", "severity": 2}
{"drug1": "codeine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with nortriptyline.", "severity": 2}
{"drug1": "estazolam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with amobarbital.", "severity": 2}
{"drug1": "triazolam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Melatonin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "doxepin", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "lidocaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Asenapine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with selegiline.", "severity": 2}
{"drug1": "trandolapril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with GUANFACINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Iloperidone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with aspirin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with isoxsuprine.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "midazolam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with bupivacaine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Ropivacaine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Rosuvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Etomidate.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with triprolidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Benidipine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with triamterene.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Apremilast.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "streptozocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with streptozocin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with carprofen.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with metolazone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with protriptyline.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Masoprocol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with cetirizine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with clomipramine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with zonisamide.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with brotizolam.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nelfinavir is combined with Temsirolimus.", "severity": 2}
{"drug1": "labetalol", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with fludiazepam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with ethotoin.", "severity": 2}
{"drug1": "diazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with tizanidine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "sulpiride", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with HEROIN.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with fenoprofen.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with tiagabine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with tranylcypromine.", "severity": 2}
{"drug1": "methysergide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with carisoprodol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with hyoscyamine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with promethazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with carisoprodol.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with metolazone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with dexamethasone.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Flibanserin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with clonazepam.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with promethazine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with quetiapine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with citalopram.", "severity": 2}
{"drug1": "triazolam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with olanzapine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with topiramate.", "severity": 2}
{"drug1": "Torasemide", "drug2": "amikacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with amikacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Aceclofenac.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with zaltoprofen.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with diltiazem.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with vigabatrin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Propoxycaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Pramocaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Olopatadine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with topiramate.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with butorphanol.", "severity": 2}
{"drug1": "reserpine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nicardipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Aliskiren.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Tasimelteon.", "severity": 2}
{"drug1": "reserpine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with maprotiline.", "severity": 2}
{"drug1": "reserpine", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with clorazepate.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with betamethasone.", "severity": 2}
{"drug1": "metaraminol", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with phenmetrazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Melatonin.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with tolfenamic acid.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with zonisamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with promethazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with clonazepam.", "severity": 2}
{"drug1": "sertraline", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with imipramine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with nisoldipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Pramocaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Arformoterol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with furosemide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with tizanidine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with HEROIN.", "severity": 2}
{"drug1": "suprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Nitroprusside.", "severity": 2}
{"drug1": "suprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with prednisone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Ketobemidone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with fludrocortisone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with triamterene.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with terazosin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Trametinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Trametinib.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with triprolidine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Deferasirox.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Afatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Afatinib.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Enalaprilat.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with methoxyflurane.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with Isoflurophate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with flumethasone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with dantrolene.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with amitriptyline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with dihydroergotamine.", "severity": 2}
{"drug1": "enflurane", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with chlorpheniramine.", "severity": 2}
{"drug1": "methysergide", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with arsenic trioxide.", "severity": 2}
{"drug1": "selegiline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with formoterol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with cyclothiazide.", "severity": 2}
{"drug1": "cocaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with glutethimide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Loxoprofen.", "severity": 2}
{"drug1": "baclofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with methazolamide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with eperisone.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with propoxyphene.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Eplerenone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Retigabine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Dienogest", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Dienogest.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with MOXONIDINE.", "severity": 2}
{"drug1": "timolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with spironolactone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with scopolamine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Hexobarbital.", "severity": 2}
{"drug1": "loratadine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Butethal.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with fludrocortisone.", "severity": 2}
{"drug1": "Retigabine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Retigabine is combined with Pizotifen.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with felbamate.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Halobetasol.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with CLONIXIN.", "severity": 2}
{"drug1": "clorazepate", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with benzyl alcohol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with triazolam.", "severity": 2}
{"drug1": "reserpine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with salicylamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with ketoprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Telmisartan.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with minoxidil.", "severity": 2}
{"drug1": "midodrine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with metaproterenol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with prilocaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Aceprometazine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with isoflurane.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with ethotoin.", "severity": 2}
{"drug1": "tiagabine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with flunarizine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with D-mannitol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with felbamate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Milnacipran.", "severity": 2}
{"drug1": "levorphanol", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with levodopa.", "severity": 2}
{"drug1": "levorphanol", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with sevoflurane.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Nabilone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Lormetazepam.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with celecoxib.", "severity": 2}
{"drug1": "tetracaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with maprotiline.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Paliperidone.", "severity": 2}
{"drug1": "carprofen", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Apremilast.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with sotalol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Risedronic acid.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Oxetacaine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with labetalol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with propranolol.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with captopril.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with clonidine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Isavuconazonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Isavuconazonium.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with bumetanide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with terbutaline.", "severity": 2}
{"drug1": "meprobamate", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with oxycodone.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with chlorothiazide.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with SERATRODAST.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Indacaterol.", "severity": 2}
{"drug1": "etizolam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with tiapride.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with naratriptan.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with MOLINDONE.", "severity": 2}
{"drug1": "cocaine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with chlormezanone.", "severity": 2}
{"drug1": "enflurane", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with primidone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with amoxapine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Cariprazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Etomidate.", "severity": 2}
{"drug1": "cocaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with doxazosin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Iloperidone.", "severity": 2}
{"drug1": "imipramine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ethotoin.", "severity": 2}
{"drug1": "imipramine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with tretinoin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with phenobarbital.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Masoprocol.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ouabain.", "severity": 2}
{"drug1": "meperidine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with propofol.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with daunorubicin.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Etoricoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with bumetanide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with quinapril.", "severity": 2}
{"drug1": "thalidomide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with chlorothiazide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with isoniazid.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with naratriptan.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with chlorthalidone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with homoharringtonine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with nitrazepam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with resveratrol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Iloperidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with levodopa.", "severity": 2}
{"drug1": "thiopental", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with chlorprothixene.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with prednisone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Levocetirizine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "enalapril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with betamethasone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with flurandrenolide.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Pimecrolimus.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Fluspirilene.", "severity": 2}
{"drug1": "tolazoline", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with bromocriptine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with fludrocortisone.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with felbamate.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Repaglinide is combined with atorvastatin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with SERTINDOLE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Pizotifen.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with flurandrenolide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Pirlindole.", "severity": 2}
{"drug1": "prednisone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with metoclopramide.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with suprofen.", "severity": 2}
{"drug1": "nabumetone", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with salicylic acid.", "severity": 2}
{"drug1": "dyphylline", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyphylline is combined with pancuronium.", "severity": 2}
{"drug1": "ramipril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroxyzine is combined with Milnacipran.", "severity": 2}
{"drug1": "Droxicam", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Phenelzine.", "severity": 2}
{"drug1": "selegiline", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with bupropion.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ximelagatran is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "haloprogin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with nimesulide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Ramelteon.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with ethotoin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with tranylcypromine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with prilocaine.", "severity": 2}
{"drug1": "furosemide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with buprenorphine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Halobetasol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Desloratadine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with thalidomide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with efavirenz.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with methylprednisolone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with indapamide.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "prazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Fencamfamin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nicardipine.", "severity": 2}
{"drug1": "dobutamine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with dyclonine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with propoxyphene.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with sulfasalazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Vilanterol.", "severity": 2}
{"drug1": "linezolid", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Bretylium.", "severity": 2}
{"drug1": "imipramine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with desipramine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with nifedipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with terbutaline.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with simvastatin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Fospropofol.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with loteprednol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with scopolamine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with reserpine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with D-mannitol.", "severity": 2}
{"drug1": "propofol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ZILEUTON.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with etodolac.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "mafenide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with mafenide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with nicardipine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Agomelatine.", "severity": 2}
{"drug1": "loratadine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with meclizine.", "severity": 2}
{"drug1": "halothane", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Nebivolol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with diflunisal.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nitric oxide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with butalbital.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with furosemide.", "severity": 2}
{"drug1": "loxapine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Retigabine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with tizanidine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with atorvastatin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Pipotiazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Fludarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Fludarabine.", "severity": 2}
{"drug1": "suprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Olopatadine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Mometasone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with benzocaine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with nisoldipine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with vigabatrin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with atenolol.", "severity": 2}
{"drug1": "tiapride", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with NITROUS ACID.", "severity": 2}
{"drug1": "tolmetin", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with mycophenolic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with flunarizine.", "severity": 2}
{"drug1": "meclizine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Pinaverium.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with vigabatrin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "irbesartan", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with trandolapril.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Melatonin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with flumethasone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Perospirone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Mersalyl.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Lornoxicam.", "severity": 2}
{"drug1": "fosinopril", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with sulfasalazine.", "severity": 2}
{"drug1": "methysergide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with mefloquine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "methysergide", "drug2": "methylergonovine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with methylergonovine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "aspirin", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with ketoprofen.", "severity": 2}
{"drug1": "enalapril", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with papaverine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with ouabain.", "severity": 2}
{"drug1": "promazine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with fludiazepam.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with moclobemide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with ambenonium.", "severity": 2}
{"drug1": "butorphanol", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with butorphanol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with alclofenac.", "severity": 2}
{"drug1": "carprofen", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "diltiazem", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with BISOPROLOL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Quinine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Quinine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Levobupivacaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with clorazepate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Aceprometazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Milnacipran.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with MOLINDONE.", "severity": 2}
{"drug1": "estrone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with Echothiophate.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Sorafenib.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Zoledronic acid.", "severity": 2}
{"drug1": "oxazepam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "reserpine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "clozapine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bevantolol is combined with pilocarpine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Pentolinium.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "procaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with vigabatrin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with epirizole.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Olopatadine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Difenoxin.", "severity": 2}
{"drug1": "pergolide", "drug2": "zafirlukast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with zafirlukast.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with formestane.", "severity": 2}
{"drug1": "moclobemide", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with dobutamine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Desloratadine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with zaleplon.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Agomelatine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with mepivacaine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Lurasidone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with flunarizine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with nitrendipine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with celiprolol.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with eperisone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with felbamate.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "clonidine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Pizotifen.", "severity": 2}
{"drug1": "Metixene", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with levorphanol.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Clevidipine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with promethazine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with efavirenz.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rivaroxaban is combined with Temsirolimus.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Efonidipine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with efavirenz.", "severity": 2}
{"drug1": "methysergide", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with danazol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with meperidine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with oxaprozin.", "severity": 2}
{"drug1": "ketamine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with clonidine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with zotepine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with imipramine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "losartan", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with sulindac.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with ethotoin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with budesonide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Fospropofol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with niflumic acid.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with suprofen.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Deferasirox.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoxsuprine is combined with Aliskiren.", "severity": 2}
{"drug1": "chloroquine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with formestane.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "ketamine", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with memantine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with tizanidine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Escitalopram.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Epirubicin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Canagliflozin.", "severity": 2}
{"drug1": "tiapride", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Milnacipran.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Pramocaine.", "severity": 2}
{"drug1": "tiapride", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Ramelteon.", "severity": 2}
{"drug1": "prilocaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with betamethasone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with sumatriptan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with trifluoperazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with estrone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Melatonin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with cilostazol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with promethazine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with terazosin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Paliperidone.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with CYCLIZINE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with AMILORIDE.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with pirenzepine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with flunarizine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with brotizolam.", "severity": 2}
{"drug1": "triamterene", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with nicardipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with terazosin.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "halothane", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Pipamperone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with tolmetin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Levocetirizine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Mephobarbital.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Ramelteon.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with nalbuphine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Pizotifen.", "severity": 2}
{"drug1": "gliclazide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gliclazide is combined with ethanol.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with oxymorphone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with captopril.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with zotepine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with prazepam.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with nilvadipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with penbutolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "codeine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with amoxapine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with felodipine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "loxapine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Lurasidone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with losartan.", "severity": 2}
{"drug1": "ropinirole", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with fosinopril.", "severity": 2}
{"drug1": "benztropine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Vecuronium.", "severity": 2}
{"drug1": "benztropine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with zotepine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with MELPERONE.", "severity": 2}
{"drug1": "benztropine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with pancuronium.", "severity": 2}
{"drug1": "lidocaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with zotepine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with apraclonidine.", "severity": 2}
{"drug1": "etizolam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with butalbital.", "severity": 2}
{"drug1": "chloroquine", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with carprofen.", "severity": 2}
{"drug1": "promazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Normethadone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with butamben.", "severity": 2}
{"drug1": "formestane", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with edrophonium.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with methyldopa.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with benazepril.", "severity": 2}
{"drug1": "leflunomide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with haloperidol.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with propoxyphene.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "quazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with amisulpride.", "severity": 2}
{"drug1": "Etomidate", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with primidone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with flunarizine.", "severity": 2}
{"drug1": "cocaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with cetirizine.", "severity": 2}
{"drug1": "procaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with phenytoin.", "severity": 2}
{"drug1": "ramipril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with cilazapril.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chlorthalidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Pizotifen.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Eplerenone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with methazolamide.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with scopolamine.", "severity": 2}
{"drug1": "benazepril", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with captopril.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "mitoxantrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with mitoxantrone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with loratadine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with amcinonide.", "severity": 2}
{"drug1": "butenafine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with gabapentin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with niflumic acid.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with imipramine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with methazolamide.", "severity": 2}
{"drug1": "benazepril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with acebutolol.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Eplerenone.", "severity": 2}
{"drug1": "butenafine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with felodipine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Olopatadine.", "severity": 2}
{"drug1": "metolazone", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with alclofenac.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with clemastine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with butalbital.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "valsartan", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with isoxsuprine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Netupitant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Netupitant.", "severity": 2}
{"drug1": "bepridil", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with pramipexole.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "doxepin", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "brotizolam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with citalopram.", "severity": 2}
{"drug1": "diflunisal", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with salicylamide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "tiapride", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with flunarizine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with tubocurarine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with trifluoperazine.", "severity": 2}
{"drug1": "Butethal", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Pizotifen.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "temazepam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "risperidone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with etizolam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with fosinopril.", "severity": 2}
{"drug1": "amiodarone", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with benazepril.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with fluvastatin.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Lorcaserin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with dantrolene.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with promazine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Fesoterodine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with bepridil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with quazepam.", "severity": 2}
{"drug1": "amobarbital", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with prazepam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "pimozide", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "pimozide", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with flunitrazepam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with oxprenolol.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with PERHEXILINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with prazepam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with quazepam.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with zopiclone.", "severity": 2}
{"drug1": "propofol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with benzocaine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with selegiline.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with nitroglycerin.", "severity": 2}
{"drug1": "propofol", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "propofol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with vigabatrin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Asenapine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with chlorzoxazone.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with nitrous oxide.", "severity": 2}
{"drug1": "equilin", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with metoclopramide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Ramelteon.", "severity": 2}
{"drug1": "sertraline", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Fencamfamin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with desipramine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with prednisone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with lisinopril.", "severity": 2}
{"drug1": "dibucaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with tetracaine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with vigabatrin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "antipyrine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with atorvastatin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Etidronic acid.", "severity": 2}
{"drug1": "estazolam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with cocaine.", "severity": 2}
{"drug1": "estazolam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with tiagabine.", "severity": 2}
{"drug1": "estazolam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with zonisamide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Escitalopram.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with ethotoin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with tranylcypromine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with isoflurane.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with prilocaine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Asenapine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with paramethasone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with amoxapine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with nortriptyline.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with atorvastatin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with budesonide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with tiapride.", "severity": 2}
{"drug1": "propranolol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Eprosartan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with trandolapril.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with tretinoin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with tubocurarine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with desoximetasone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with methocarbamol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with spironolactone.", "severity": 2}
{"drug1": "furosemide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with cilazapril.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with homoharringtonine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with cilazapril.", "severity": 2}
{"drug1": "enflurane", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with flunitrazepam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Lormetazepam.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Tixocortol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with equilin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "ATROPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with ATROPINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Fluspirilene.", "severity": 2}
{"drug1": "sotalol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Cevimeline.", "severity": 2}
{"drug1": "sotalol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with nicotine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Levalbuterol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with clidinium.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Bambuterol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Butethal.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Clevidipine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Fospropofol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with HYDROCODONE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with clenbuterol.", "severity": 2}
{"drug1": "morniflumate", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with flurbiprofen.", "severity": 2}
{"drug1": "labetalol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with bumetanide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with prednisone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with protriptyline.", "severity": 2}
{"drug1": "clorazepate", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with dipyridamole.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with azelastine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with cetirizine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with Pizotifen.", "severity": 2}
{"drug1": "procaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with nifedipine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with vigabatrin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with fludiazepam.", "severity": 2}
{"drug1": "haloprogin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with isradipine.", "severity": 2}
{"drug1": "codeine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with vigabatrin.", "severity": 2}
{"drug1": "codeine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Sacubitril.", "severity": 2}
{"drug1": "codeine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with benzocaine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with flurbiprofen.", "severity": 2}
{"drug1": "flurazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with thiamylal.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Vismodegib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Vismodegib.", "severity": 2}
{"drug1": "benazepril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with etodolac.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with rivastigmine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with etodolac.", "severity": 2}
{"drug1": "pentazocine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "benazepril", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with D-mannitol.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with benzocaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with vigabatrin.", "severity": 2}
{"drug1": "risperidone", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with nitrous oxide.", "severity": 2}
{"drug1": "benazepril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with ZILEUTON.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Trovafloxacin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with clonidine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with fleroxacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with chlorothiazide.", "severity": 2}
{"drug1": "butamben", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with dantrolene.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with bumetanide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "fluconazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluconazole is combined with oxycodone.", "severity": 2}
{"drug1": "scopolamine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Normethadone.", "severity": 2}
{"drug1": "thiopental", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with zotepine.", "severity": 2}
{"drug1": "thiopental", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with MELPERONE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Alvimopan.", "severity": 2}
{"drug1": "alclofenac", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with equilin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Etidocaine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Lormetazepam.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with mecamylamine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with GUANFACINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with efavirenz.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with nefazodone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Mometasone.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with nitrendipine.", "severity": 2}
{"drug1": "temazepam", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with buspirone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with DESFLURANE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with flurandrenolide.", "severity": 2}
{"drug1": "estazolam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with ondansetron.", "severity": 2}
{"drug1": "tretinoin", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with AMILORIDE.", "severity": 2}
{"drug1": "propofol", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with dibucaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with ethotoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with doxazosin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with tranylcypromine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with pancuronium.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with pyridostigmine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with celecoxib.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Pentolinium.", "severity": 2}
{"drug1": "tretinoin", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with labetalol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Pipotiazine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with resveratrol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with apraclonidine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Pizotifen.", "severity": 2}
{"drug1": "timolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Levetiracetam.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with betamethasone.", "severity": 2}
{"drug1": "quazepam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with triflupromazine.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlortetracycline is combined with tretinoin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with methocarbamol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with Demecarium.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with spironolactone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with triprolidine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Aceprometazine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with MOLINDONE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "dimethyl sulfoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with dimethyl sulfoxide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "isradipine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with metolazone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "pergolide", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with arsenic trioxide.", "severity": 2}
{"drug1": "pergolide", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with cilostazol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with topiramate.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Bivalirudin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Bivalirudin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with amisulpride.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with flumethasone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with dibucaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with metolazone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Olopatadine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Remoxipride.", "severity": 2}
{"drug1": "nystatin", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with nitrendipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Fluprednidene.", "severity": 2}
{"drug1": "Droxicam", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with fluocinonide.", "severity": 2}
{"drug1": "aspirin", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Droxicam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with DESFLURANE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Arformoterol.", "severity": 2}
{"drug1": "morniflumate", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with acemetacin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with clonidine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with imipramine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Perospirone.", "severity": 2}
{"drug1": "Eribulin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eribulin is combined with clozapine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with loratadine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "disulfiram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metronidazole is combined with disulfiram.", "severity": 2}
{"drug1": "amobarbital", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Ramelteon.", "severity": 2}
{"drug1": "halothane", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with amisulpride.", "severity": 2}
{"drug1": "Perospirone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "butamben", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Butethal.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with amobarbital.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Dapagliflozin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with lithium ion.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Hexobarbital.", "severity": 2}
{"drug1": "pargyline", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with apraclonidine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with penbutolol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Difenoxin.", "severity": 2}
{"drug1": "midazolam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with efavirenz.", "severity": 2}
{"drug1": "halcinonide", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with ambenonium.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with benzphetamine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with lisinopril.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Articaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with etizolam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with felodipine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with carisoprodol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with clonazepam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with promethazine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with pentazocine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Articaine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with butamben.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with haloperidol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Perospirone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with benzyl alcohol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with tiagabine.", "severity": 2}
{"drug1": "captopril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with ibuprofen.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with zonisamide.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Milnacipran.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with metoprolol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "nadolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Nebivolol.", "severity": 2}
{"drug1": "medrysone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with metoclopramide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Ramelteon.", "severity": 2}
{"drug1": "valsartan", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Clevidipine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Aliskiren.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with oxycodone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with buspirone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Etidocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with dibucaine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with ADAPALENE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with paroxetine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "isradipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with cilazapril.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with citalopram.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Repaglinide.", "severity": 2}
{"drug1": "reserpine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with bupivacaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Etomidate.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with doxazosin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with levodopa.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Levetiracetam.", "severity": 2}
{"drug1": "butorphanol", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with midazolam.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with nifedipine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nitrendipine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with chlormezanone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Escitalopram.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "levallorphan", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levallorphan is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "quinapril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Milnacipran.", "severity": 2}
{"drug1": "meclizine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Difenoxin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with oxymetholone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with clidinium.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with proparacaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Asenapine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Difenoxin.", "severity": 2}
{"drug1": "Apremilast", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with flunisolide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Halazepam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with methylprednisolone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Etidocaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with fenbufen.", "severity": 2}
{"drug1": "perphenazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with bumetanide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with estrone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with quinapril.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with chlorothiazide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Lormetazepam.", "severity": 2}
{"drug1": "midazolam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with chlormezanone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Eprosartan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with tizanidine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with quinapril.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with estrone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with bumetanide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with cocaine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with papaverine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with chlorzoxazone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with sertraline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with loratadine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with DEZOCINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "diazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with olanzapine.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "deferoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when l-ascorbic acid is combined with deferoxamine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Bambuterol.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with flunarizine.", "severity": 2}
{"drug1": "morphine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Levomilnacipran.", "severity": 2}
{"drug1": "nimodipine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with enalapril.", "severity": 2}
{"drug1": "buspirone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with zonisamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Pizotifen.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "TRIPTORELIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with TRIPTORELIN.", "severity": 2}
{"drug1": "perphenazine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with VERAPAMIL.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Regorafenib.", "severity": 2}
{"drug1": "Tramadol", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with butorphanol.", "severity": 2}
{"drug1": "buspirone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with tiagabine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Levocetirizine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with cetirizine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with protriptyline.", "severity": 2}
{"drug1": "glimepiride", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glimepiride is combined with ethanol.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with polythiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with droperidol.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with formoterol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with valsartan.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Torasemide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with MELPERONE.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with tolazoline.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with acemetacin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with ramipril.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Dasatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Dasatinib.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with chlormezanone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "anagrelide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with anagrelide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "carprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with formestane.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Lapatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Lapatinib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with zotepine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with methoxyflurane.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "enflurane", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with nabumetone.", "severity": 2}
{"drug1": "Spirapril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with ketorolac.", "severity": 2}
{"drug1": "Spirapril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with tenoxicam.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with estrone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Olopatadine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Nebivolol.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Crizotinib is combined with oxycodone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with diflorasone.", "severity": 2}
{"drug1": "morphine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with DEZOCINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with zaltoprofen.", "severity": 2}
{"drug1": "morphine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with minoxidil.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with SERATRODAST.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "prazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Ramelteon.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Torasemide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with citalopram.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with ouabain.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Fluspirilene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with flunarizine.", "severity": 2}
{"drug1": "clozapine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with DEZOCINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with AMILORIDE.", "severity": 2}
{"drug1": "buspirone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with chloral hydrate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Icatibant", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with formestane.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with oxprenolol.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Pregabalin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Normethadone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Tixocortol.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Clevidipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with epirizole.", "severity": 2}
{"drug1": "HEROIN", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with desipramine.", "severity": 2}
{"drug1": "thiopental", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with chlorzoxazone.", "severity": 2}
{"drug1": "quinapril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "clozapine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Fencamfamin.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with metoclopramide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Pomalidomide.", "severity": 2}
{"drug1": "baclofen", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with METAXALONE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with ethosuximide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with PROCATEROL.", "severity": 2}
{"drug1": "protriptyline", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with rasagiline.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with flurandrenolide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Lormetazepam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Aliskiren.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with papaverine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nifedipine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Echothiophate.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Enalaprilat.", "severity": 2}
{"drug1": "amifostine", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Carbetocin.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with norfloxacin.", "severity": 2}
{"drug1": "prazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with estazolam.", "severity": 2}
{"drug1": "memantine", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when memantine is combined with Carbamylcholine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Levocetirizine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with tiagabine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with selegiline.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Clobetasone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with zonisamide.", "severity": 2}
{"drug1": "promazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Etidocaine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with dantrolene.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Lofexidine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with resveratrol.", "severity": 2}
{"drug1": "pimozide", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with butalbital.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with tolmetin.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with leflunomide.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with tiagabine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with zonisamide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Olopatadine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Pipamperone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with dyclonine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with propoxyphene.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Canagliflozin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "IMIQUIMOD", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Etomidate", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with cetirizine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Lornoxicam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with METAXALONE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Fospropofol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Olopatadine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Levobupivacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Mephobarbital.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with meclizine.", "severity": 2}
{"drug1": "propofol", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with oxazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with mesoridazine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Aliskiren.", "severity": 2}
{"drug1": "celecoxib", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with niflumic acid.", "severity": 2}
{"drug1": "enalapril", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Vandetanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Vandetanib.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Vecuronium.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with pancuronium.", "severity": 2}
{"drug1": "budesonide", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with pyridostigmine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with pramipexole.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with medrysone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with mianserin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with physostigmine.", "severity": 2}
{"drug1": "midazolam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with flunitrazepam.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with mefenamic acid.", "severity": 2}
{"drug1": "cabergoline", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with midazolam.", "severity": 2}
{"drug1": "rasagiline", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with SERTINDOLE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with trimipramine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with thiamylal.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with brotizolam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with chlorzoxazone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with halothane.", "severity": 2}
{"drug1": "flurazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with flunarizine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "albendazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with albendazole.", "severity": 2}
{"drug1": "midazolam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Tolvaptan.", "severity": 2}
{"drug1": "codeine", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Tolvaptan.", "severity": 2}
{"drug1": "codeine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Asenapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Pipotiazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with dantrolene.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with topiramate.", "severity": 2}
{"drug1": "ketamine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with thiothixene.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINESTROL is combined with Ospemifene.", "severity": 2}
{"drug1": "ketamine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Pipotiazine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with D-mannitol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with prednisone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with furosemide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with nifedipine.", "severity": 2}
{"drug1": "triamterene", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with dipyridamole.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with diazoxide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nitrous oxide.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Imatinib is combined with Flibanserin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with benzyl alcohol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Ziprasidone.", "severity": 2}
{"drug1": "epinephrine", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with phenmetrazine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with topiramate.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with perphenazine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Benidipine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Milnacipran.", "severity": 2}
{"drug1": "itraconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with manidipine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with ZILEUTON.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with linezolid.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Aripiprazole.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Canrenoic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with zaltoprofen.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with brotizolam.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Riociguat.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Aceclofenac.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with etodolac.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Lurasidone.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinblastine is combined with atorvastatin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with physostigmine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with ramipril.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with ropinirole.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with baclofen.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with nitrous oxide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with memantine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with zaleplon.", "severity": 2}
{"drug1": "haloperidol", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with mepivacaine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with flunarizine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Pefloxacin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "oxymetholone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with oxymetholone.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with tizanidine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with antipyrine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with physostigmine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with benzyl alcohol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with ritodrine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with rivastigmine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with doxorubicin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Icatibant.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Difenoxin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Articaine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with norfloxacin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with Echothiophate.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with quazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with lidocaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Iloperidone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with loratadine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with imipramine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with metolazone.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with terazosin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with ethotoin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Fluprednidene.", "severity": 2}
{"drug1": "methysergide", "drug2": "clotrimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clotrimazole.", "severity": 2}
{"drug1": "methysergide", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with lithium ion.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Etidocaine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with pramipexole.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with clonidine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with difluprednate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with imipramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with prazosin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with loratadine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with primidone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Fospropofol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with minoxidil.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with baclofen.", "severity": 2}
{"drug1": "dyclonine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Sacubitril.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Tasimelteon.", "severity": 2}
{"drug1": "methoxamine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with dopamine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with losartan.", "severity": 2}
{"drug1": "butabarbital", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with GUANFACINE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with dapsone.", "severity": 2}
{"drug1": "methysergide", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ifosfamide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with medrysone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with venlafaxine.", "severity": 2}
{"drug1": "morphine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with sevoflurane.", "severity": 2}
{"drug1": "butorphanol", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with procarbazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with atorvastatin.", "severity": 2}
{"drug1": "risperidone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with MELPERONE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with SUFENTANIL.", "severity": 2}
{"drug1": "sulpiride", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with methylphenidate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with methocarbamol.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with flunarizine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Fluspirilene.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Ramelteon.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with prednisone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "morphine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Efonidipine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with butalbital.", "severity": 2}
{"drug1": "glutethimide", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with tetracaine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Efonidipine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with NAPROXEN.", "severity": 2}
{"drug1": "isoflurane", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with furosemide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with dantrolene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with tizanidine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with phentolamine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with tiapride.", "severity": 2}
{"drug1": "propantheline", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with Butylscopolamine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Eprosartan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with haloperidol.", "severity": 2}
{"drug1": "sulpiride", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with digoxin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with butorphanol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Pizotifen.", "severity": 2}
{"drug1": "sulpiride", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with carisoprodol.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with cetirizine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Lormetazepam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with nortriptyline.", "severity": 2}
{"drug1": "proparacaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with amoxapine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with loteprednol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with physostigmine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with clidinium.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with papaverine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with rivastigmine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "sulindac", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with suprofen.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with tizanidine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Deferasirox.", "severity": 2}
{"drug1": "Butethal", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with sertraline.", "severity": 2}
{"drug1": "valsartan", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with acebutolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Iloperidone.", "severity": 2}
{"drug1": "valsartan", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with captopril.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Pregabalin.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with Ketobemidone.", "severity": 2}
{"drug1": "procaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with levorphanol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Fluspirilene.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Riociguat.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with fluvoxamine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Cevimeline.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with Retigabine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Etidocaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "triazolam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with SERTINDOLE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Aceclofenac.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with zaltoprofen.", "severity": 2}
{"drug1": "sertraline", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with bromocriptine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Levetiracetam.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with oxycodone.", "severity": 2}
{"drug1": "bumetanide", "drug2": "ribostamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with ribostamycin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with equilin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "pergolide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with clozapine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with papaverine.", "severity": 2}
{"drug1": "pergolide", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with vinorelbine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nifedipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with halothane.", "severity": 2}
{"drug1": "midazolam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with methocarbamol.", "severity": 2}
{"drug1": "midazolam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with triprolidine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with bumetanide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with quinapril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with chlorothiazide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "procaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with Aliskiren.", "severity": 2}
{"drug1": "amisulpride", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with ethotoin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Eprosartan.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Remoxipride.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with floctafenine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Etidocaine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Salmeterol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with METAXALONE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Clobetasone.", "severity": 2}
{"drug1": "ramipril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with flurbiprofen.", "severity": 2}
{"drug1": "halothane", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with maprotiline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with PROCATEROL.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Riociguat.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with GUANFACINE.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with oxycodone.", "severity": 2}
{"drug1": "midazolam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with carisoprodol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Sacubitril.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with triflupromazine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with mefloquine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Retigabine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with fexofenadine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with rizatriptan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with naratriptan.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with trimipramine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with lidocaine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Canagliflozin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with procaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Dapagliflozin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Salsalate.", "severity": 2}
{"drug1": "desipramine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with periciazine.", "severity": 2}
{"drug1": "triazolam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with gabapentin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with triprolidine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with doxepin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with spironolactone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with methocarbamol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with nefazodone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with METAXALONE.", "severity": 2}
{"drug1": "bromazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "losartan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with quetiapine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "metolazone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with estrone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Pipotiazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with NITROUS ACID.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with Vecuronium.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Teriflunomide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with trimipramine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Metipranolol.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with epirizole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Propoxycaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Pramocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with fexofenadine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with triazolam.", "severity": 2}
{"drug1": "bepridil", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with reserpine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with HEROIN.", "severity": 2}
{"drug1": "butamben", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with etizolam.", "severity": 2}
{"drug1": "floctafenine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "butamben", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with flunarizine.", "severity": 2}
{"drug1": "halothane", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Olopatadine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with formoterol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with medrysone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Desloratadine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with mepivacaine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with zaleplon.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ropinirole.", "severity": 2}
{"drug1": "bromazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with thiopental.", "severity": 2}
{"drug1": "formestane", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with sparfloxacin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with vigabatrin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "procaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Etidocaine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with primidone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "amiodarone", "drug2": "arsenic trioxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with arsenic trioxide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Clobetasone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with flunarizine.", "severity": 2}
{"drug1": "Alvimopan", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alvimopan is combined with Naloxegol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with brotizolam.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with pancuronium.", "severity": 2}
{"drug1": "oxazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with maprotiline.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with medrysone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with nortriptyline.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with amoxapine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Milnacipran.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Vecuronium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Ciclesonide.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Torasemide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with oxprenolol.", "severity": 2}
{"drug1": "halothane", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with fosinopril.", "severity": 2}
{"drug1": "prednisone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with fleroxacin.", "severity": 2}
{"drug1": "amifostine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with pramipexole.", "severity": 2}
{"drug1": "clozapine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Etidocaine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Vecuronium.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with ritonavir.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with dexamethasone.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with Olsalazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with desipramine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with alclometasone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nitroglycerin.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with paroxetine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Escitalopram.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with furosemide.", "severity": 2}
{"drug1": "propofol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "dyclonine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with chlormezanone.", "severity": 2}
{"drug1": "propofol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with glutethimide.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with HEROIN.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with oxymorphone.", "severity": 2}
{"drug1": "hexetidine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with flunarizine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Levetiracetam.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with methadone.", "severity": 2}
{"drug1": "meperidine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with flurazepam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with doxepin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with pravastatin.", "severity": 2}
{"drug1": "meperidine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with tizanidine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with captopril.", "severity": 2}
{"drug1": "diclofenac", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with diflorasone.", "severity": 2}
{"drug1": "benzocaine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "periciazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when periciazine is combined with methylphenidate.", "severity": 2}
{"drug1": "etodolac", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with amcinonide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with bumetanide.", "severity": 2}
{"drug1": "codeine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Pizotifen.", "severity": 2}
{"drug1": "etodolac", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "dibucaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Cis-mdp.", "severity": 2}
{"drug1": "meperidine", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with potassium ion.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with phenytoin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Clobetasone.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with tetracaine.", "severity": 2}
{"drug1": "codeine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with mesoridazine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with minoxidil.", "severity": 2}
{"drug1": "moclobemide", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with reserpine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Pipotiazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with lisinopril.", "severity": 2}
{"drug1": "meperidine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with mepivacaine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Pipamperone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "carboplatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sorafenib is combined with carboplatin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Pramocaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with topiramate.", "severity": 2}
{"drug1": "enflurane", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with tizanidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Propoxycaine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with levorphanol.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with indapamide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with butamben.", "severity": 2}
{"drug1": "antipyrine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ethotoin.", "severity": 2}
{"drug1": "codeine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with maprotiline.", "severity": 2}
{"drug1": "Tramadol", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with isoflurane.", "severity": 2}
{"drug1": "Tramadol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with prilocaine.", "severity": 2}
{"drug1": "argatroban", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with Apixaban.", "severity": 2}
{"drug1": "polythiazide", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with diazoxide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Olopatadine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Tolcapone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with difluprednate.", "severity": 2}
{"drug1": "butabarbital", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with primidone.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Aliskiren.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with MOLINDONE.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Lercanidipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with butamben.", "severity": 2}
{"drug1": "paroxetine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with imipramine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with desoximetasone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "isradipine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with cyclopentolate.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with mepivacaine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with metoclopramide.", "severity": 2}
{"drug1": "loratadine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "methysergide", "drug2": "Luliconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Luliconazole.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with lithium ion.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with scopolamine.", "severity": 2}
{"drug1": "Articaine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with tiapride.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "melphalan", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when melphalan is combined with leflunomide.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyridostigmine is combined with nicotine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyridostigmine is combined with Cevimeline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with paroxetine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with levorphanol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with ibuprofen.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with hydromorphone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with baclofen.", "severity": 2}
{"drug1": "clorazepate", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with efavirenz.", "severity": 2}
{"drug1": "meperidine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with nitrous oxide.", "severity": 2}
{"drug1": "citalopram", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Pipamperone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "ritodrine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Epirubicin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with DEZOCINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Flupentixol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atorvastatin is combined with rescinnamine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritonavir is combined with meperidine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Ketobemidone.", "severity": 2}
{"drug1": "temazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "lorazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with clonazepam.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with promethazine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with phenytoin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Melatonin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with butamben.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with methscopolamine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Milnacipran.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with benzocaine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with vigabatrin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Enasidenib.", "severity": 2}
{"drug1": "clozapine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nifedipine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Fospropofol.", "severity": 2}
{"drug1": "clozapine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with papaverine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with tenoxicam.", "severity": 2}
{"drug1": "baclofen", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Retigabine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with lithium ion.", "severity": 2}
{"drug1": "baclofen", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "quazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with paroxetine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remikiren is combined with Temsirolimus.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "morphine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "morphine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with chlorothiazide.", "severity": 2}
{"drug1": "morphine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with bumetanide.", "severity": 2}
{"drug1": "butamben", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with fexofenadine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Olopatadine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "propantheline", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with tolterodine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "procarbazine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with moclobemide.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Clevidipine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with propofol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with Fencamfamin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with baclofen.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with trazodone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Olopatadine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Propacetamol.", "severity": 2}
{"drug1": "pergolide", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with clotiazepam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Lurasidone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with fexofenadine.", "severity": 2}
{"drug1": "nystatin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with bepridil.", "severity": 2}
{"drug1": "zopiclone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with lidocaine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with salicylamide.", "severity": 2}
{"drug1": "midazolam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "pergolide", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with cisapride.", "severity": 2}
{"drug1": "enalapril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with ibuprofen.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Ramelteon.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Arotinolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Arotinolol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with triprolidine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with ZILEUTON.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with etodolac.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Difenoxin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Butethal.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with cilazapril.", "severity": 2}
{"drug1": "Tramadol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with spironolactone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with minoxidil.", "severity": 2}
{"drug1": "paroxetine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with MOLINDONE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Tasimelteon.", "severity": 2}
{"drug1": "toremifene", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when toremifene is combined with Ospemifene.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with periciazine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with imipramine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with nortriptyline.", "severity": 2}
{"drug1": "nimesulide", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with acebutolol.", "severity": 2}
{"drug1": "cilazapril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Torasemide.", "severity": 2}
{"drug1": "linezolid", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Lurasidone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with loratadine.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with nimesulide.", "severity": 2}
{"drug1": "selegiline", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with acebutolol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with midazolam.", "severity": 2}
{"drug1": "bumetanide", "drug2": "paromomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with paromomycin.", "severity": 2}
{"drug1": "Ezetimibe", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ezetimibe is combined with atorvastatin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Desloratadine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with mepivacaine.", "severity": 2}
{"drug1": "pergolide", "drug2": "histamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with histamine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with Levomilnacipran.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with clenbuterol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Levocetirizine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Retigabine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with Bambuterol.", "severity": 2}
{"drug1": "thiopental", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Lormetazepam.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with METAXALONE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Fospropofol.", "severity": 2}
{"drug1": "reserpine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "reserpine", "drug2": "pentobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with pentobarbital.", "severity": 2}
{"drug1": "reserpine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chlorthalidone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with halothane.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Bretylium.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Thioproperazine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with thiothixene.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with carisoprodol.", "severity": 2}
{"drug1": "reserpine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with codeine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Propoxycaine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "trazodone", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetrahydrozoline is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cobicistat is combined with oxycodone.", "severity": 2}
{"drug1": "quinapril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with indomethacin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with amisulpride.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "quinapril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Masoprocol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with fexofenadine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with butamben.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with oxymetazoline.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Apremilast", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Iloperidone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with ritodrine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with Pinaverium.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with polythiazide.", "severity": 2}
{"drug1": "diazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "diazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Venetoclax", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Venetoclax.", "severity": 2}
{"drug1": "tolmetin", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Pipamperone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with cetirizine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with MOLINDONE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with protriptyline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Nepafenac.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with tubocurarine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Salsalate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "methotrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfisoxazole is combined with methotrexate.", "severity": 2}
{"drug1": "thiopental", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with clonidine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Retigabine.", "severity": 2}
{"drug1": "captopril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Salsalate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Tixocortol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with D-mannitol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with triflupromazine.", "severity": 2}
{"drug1": "mafenide", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mafenide is combined with prilocaine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with cilnidipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with scopolamine.", "severity": 2}
{"drug1": "methysergide", "drug2": "cyclosporin A", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with cyclosporin A.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Lacidipine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with D-mannitol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with tubocurarine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with cinoxacin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "azithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with azithromycin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "pergolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with pergolide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "caffeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with caffeine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Escitalopram.", "severity": 2}
{"drug1": "buspirone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with halothane.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with vigabatrin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "busulfan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when busulfan is combined with clozapine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "buspirone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with desipramine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Levetiracetam.", "severity": 2}
{"drug1": "buspirone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with thiamylal.", "severity": 2}
{"drug1": "reserpine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with isoxsuprine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "duloxetine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with moclobemide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Fencamfamin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with fluoxetine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Salsalate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Apremilast", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with flumethasone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Lurasidone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with D-mannitol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with diflunisal.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with dibucaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with nitrendipine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "EXEMESTANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with EXEMESTANE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Methyl aminolevulinate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Methyl aminolevulinate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "azathioprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with azathioprine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with betamethasone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with doxorubicin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Paliperidone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Oxetacaine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Dapagliflozin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with hydrocortisone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with phenobarbital.", "severity": 2}
{"drug1": "pimozide", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Aceprometazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Pizotifen.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "nimodipine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Pipotiazine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with tubocurarine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with ethosuximide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with AMILORIDE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with flunitrazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with carvedilol.", "severity": 2}
{"drug1": "zaleplon", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with butalbital.", "severity": 2}
{"drug1": "Naftifine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with barnidipine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with flunarizine.", "severity": 2}
{"drug1": "promazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Amrinone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Fluspirilene.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with flunarizine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with selegiline.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with desipramine.", "severity": 2}
{"drug1": "Articaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with tizanidine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Vorapaxar", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Vorapaxar.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with metyrapone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with glyburide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "paramethasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Oxetacaine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with oxymorphone.", "severity": 2}
{"drug1": "amifostine", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Bortezomib.", "severity": 2}
{"drug1": "minoxidil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with primidone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with MOXONIDINE.", "severity": 2}
{"drug1": "propofol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with hydralazine.", "severity": 2}
{"drug1": "diazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with tetracycline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with tranylcypromine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Lornoxicam.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with epirizole.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Aliskiren.", "severity": 2}
{"drug1": "Spirapril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with salicylamide.", "severity": 2}
{"drug1": "amifostine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with imipramine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with flunitrazepam.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with metoclopramide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with butalbital.", "severity": 2}
{"drug1": "procaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with clomipramine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with dibucaine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with chlorzoxazone.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "alprostadil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with alprostadil.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with olanzapine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "tirofiban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with tirofiban.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with methadone.", "severity": 2}
{"drug1": "benztropine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with meperidine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Pregabalin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Fluspirilene.", "severity": 2}
{"drug1": "terconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "HEROIN", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with zotepine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with MELPERONE.", "severity": 2}
{"drug1": "aspirin", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with sertraline.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Lornoxicam.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Fesoterodine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Salmeterol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with decamethonium.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Pomalidomide.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with Levocetirizine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with clonazepam.", "severity": 2}
{"drug1": "propantheline", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with pirenzepine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Halobetasol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with quetiapine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with metaproterenol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with oxybutynin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Pipamperone.", "severity": 2}
{"drug1": "pancuronium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with oxycodone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with danazol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with isocarboxazid.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with epoprostenol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with clomipramine.", "severity": 2}
{"drug1": "carprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with betamethasone.", "severity": 2}
{"drug1": "methysergide", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with rapamycin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with dantrolene.", "severity": 2}
{"drug1": "imipramine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with AMILORIDE.", "severity": 2}
{"drug1": "imipramine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ethosuximide.", "severity": 2}
{"drug1": "imipramine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with doxazosin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with dibucaine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "tiapride", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with promethazine.", "severity": 2}
{"drug1": "tiapride", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with clonazepam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with furazolidone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Perospirone.", "severity": 2}
{"drug1": "equilin", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with memantine.", "severity": 2}
{"drug1": "equilin", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Gatifloxacin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Efonidipine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with procarbazine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with isoxsuprine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Aceprometazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with chlorpheniramine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with betamethasone.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with fenoprofen.", "severity": 2}
{"drug1": "aspirin", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Ciclesonide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "pipobroman", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with pipobroman.", "severity": 2}
{"drug1": "enflurane", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Difenoxin.", "severity": 2}
{"drug1": "indapamide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with isoxsuprine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Tolcapone.", "severity": 2}
{"drug1": "thiothixene", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with amitriptyline.", "severity": 2}
{"drug1": "trazodone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with clomipramine.", "severity": 2}
{"drug1": "trazodone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with isocarboxazid.", "severity": 2}
{"drug1": "fenbufen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with methylprednisolone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Propacetamol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with triamterene.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Levocetirizine.", "severity": 2}
{"drug1": "suprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with loteprednol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Rotigotine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Oxetacaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with diazepam.", "severity": 2}
{"drug1": "aspirin", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with halcinonide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Bretylium.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with nalidixic acid.", "severity": 2}
{"drug1": "propofol", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with chlorprothixene.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with malathion.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "propofol", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with sevoflurane.", "severity": 2}
{"drug1": "Asenapine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with nitrous oxide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "ramipril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with oxaprozin.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with metoclopramide.", "severity": 2}
{"drug1": "ramipril", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with loxapine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Remoxipride.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Olmesartan.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Apremilast.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with nicardipine.", "severity": 2}
{"drug1": "butalbital", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with NITROUS ACID.", "severity": 2}
{"drug1": "valsartan", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Icatibant.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Enalaprilat.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with malathion.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Flupentixol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Normethadone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with spironolactone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with chlormezanone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Dothiepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Dothiepin.", "severity": 2}
{"drug1": "isradipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "risperidone", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with trazodone.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with prazosin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with methadone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with felbamate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with fluocinonide.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with penbutolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with dyclonine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with desoximetasone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with clonazepam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Pramocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Levocetirizine.", "severity": 2}
{"drug1": "enflurane", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with tiagabine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with topiramate.", "severity": 2}
{"drug1": "enflurane", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with ondansetron.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Propoxycaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with amisulpride.", "severity": 2}
{"drug1": "haloperidol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with chloral hydrate.", "severity": 2}
{"drug1": "enflurane", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with zonisamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with quazepam.", "severity": 2}
{"drug1": "prednisone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with cinoxacin.", "severity": 2}
{"drug1": "Cis-mdp", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cis-mdp is combined with Deferasirox.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with tolterodine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with clemastine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with nitrendipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with estazolam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with baclofen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with fluocinonide.", "severity": 2}
{"drug1": "morphine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with hydromorphone.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with duloxetine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with nicotine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with Cevimeline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with digitoxin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with brotizolam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Pizotifen.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "benzocaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with butamben.", "severity": 2}
{"drug1": "valsartan", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with furosemide.", "severity": 2}
{"drug1": "valsartan", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with tizanidine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "melphalan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with melphalan.", "severity": 2}
{"drug1": "valsartan", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Tramadol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with halothane.", "severity": 2}
{"drug1": "quazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Etomidate.", "severity": 2}
{"drug1": "mesalamine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with hydrocortisone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with felbamate.", "severity": 2}
{"drug1": "ketamine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with bupivacaine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with nifedipine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paricalcitol is combined with Calcipotriol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Riociguat.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with papaverine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "betaxolol", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with isradipine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Olmesartan.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with flunarizine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Pirlindole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with paroxetine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with oxprenolol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with prazepam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with chlorpheniramine.", "severity": 2}
{"drug1": "topiramate", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with clidinium.", "severity": 2}
{"drug1": "valsartan", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Olsalazine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with formestane.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with felbamate.", "severity": 2}
{"drug1": "trandolapril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with brotizolam.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Milnacipran.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Butethal", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with fexofenadine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Lumiracoxib.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with Metixene.", "severity": 2}
{"drug1": "propranolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "triazolam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with MELPERONE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with ESMOLOL.", "severity": 2}
{"drug1": "benztropine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with nalbuphine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with CARTEOLOL.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with metolazone.", "severity": 2}
{"drug1": "azelastine", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with diflorasone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Oxetacaine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with protriptyline.", "severity": 2}
{"drug1": "pergolide", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with chloramphenicol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Ziprasidone.", "severity": 2}
{"drug1": "pergolide", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with teniposide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with carisoprodol.", "severity": 2}
{"drug1": "methoxamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "captopril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with quetiapine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with procaine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with trimipramine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with procaine.", "severity": 2}
{"drug1": "pergolide", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with lansoprazole.", "severity": 2}
{"drug1": "Torasemide", "drug2": "paromomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with paromomycin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with MELPERONE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with zotepine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with enoxacin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with budesonide.", "severity": 2}
{"drug1": "trazodone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Pomalidomide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with nabumetone.", "severity": 2}
{"drug1": "morniflumate", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with ketorolac.", "severity": 2}
{"drug1": "clomipramine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with timolol.", "severity": 2}
{"drug1": "morniflumate", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with tenoxicam.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with propofol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with methocarbamol.", "severity": 2}
{"drug1": "prazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Normethadone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with fludiazepam.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Tramadol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with spironolactone.", "severity": 2}
{"drug1": "ramipril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Temsirolimus.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "desipramine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with dobutamine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with losartan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with thioridazine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with quetiapine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with promazine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with methocarbamol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with ketamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with baclofen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with quetiapine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "methoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with methoxamine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Canagliflozin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "baclofen", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with tiagabine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Salmeterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Salmeterol.", "severity": 2}
{"drug1": "triazolam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with efavirenz.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with maprotiline.", "severity": 2}
{"drug1": "baclofen", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with zonisamide.", "severity": 2}
{"drug1": "prazosin", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with lisinopril.", "severity": 2}
{"drug1": "isoflurane", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with atenolol.", "severity": 2}
{"drug1": "prazosin", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with nitroglycerin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with propofol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with nitroglycerin.", "severity": 2}
{"drug1": "reserpine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with DEZOCINE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with lisinopril.", "severity": 2}
{"drug1": "docetaxel", "drug2": "suramin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with suramin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Loxoprofen.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with DEZOCINE.", "severity": 2}
{"drug1": "propofol", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with efavirenz.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Droxicam.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with oxycodone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Fospropofol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with homoharringtonine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "captopril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with fenoprofen.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with butalbital.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Tapentadol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with tizanidine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Pramocaine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Iloperidone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Propoxycaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with prazepam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with quazepam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with isoxsuprine.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Pomalidomide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with chlormezanone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with oxprenolol.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with phenytoin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with desoximetasone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "Articaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with MELPERONE.", "severity": 2}
{"drug1": "Articaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with zotepine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Pizotifen.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with bezafibrate.", "severity": 2}
{"drug1": "captopril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "meprobamate", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with butorphanol.", "severity": 2}
{"drug1": "etodolac", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Pipotiazine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with thiothixene.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Thioproperazine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with potassium ion.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ketoprofen.", "severity": 2}
{"drug1": "amobarbital", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with fluvoxamine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Retigabine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Metixene.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with furazolidone.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with flunarizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with clonidine.", "severity": 2}
{"drug1": "estazolam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with triflupromazine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "ketamine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with maprotiline.", "severity": 2}
{"drug1": "ropinirole", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with mecamylamine.", "severity": 2}
{"drug1": "ketamine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with mesoridazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Flupentixol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with methyclothiazide.", "severity": 2}
{"drug1": "ramipril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with tolmetin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Phenelzine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with flunitrazepam.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "diazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with clemastine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with lidocaine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with spironolactone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with chlormezanone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Pipotiazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with venlafaxine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with nitrendipine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with pentazocine.", "severity": 2}
{"drug1": "biperiden", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with HEROIN.", "severity": 2}
{"drug1": "selegiline", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "CYPROTERONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with meclizine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with felbamate.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Naloxegol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Hexobarbital.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Empagliflozin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with diflorasone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with ESMOLOL.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with ibuprofen.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Levocetirizine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with DESONIDE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with clonazepam.", "severity": 2}
{"drug1": "gabapentin", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with promethazine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Metipranolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with triprolidine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Clobetasone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with methylphenidate.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with methocarbamol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with rasagiline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with suprofen.", "severity": 2}
{"drug1": "methysergide", "drug2": "Netupitant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Netupitant.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "antipyrine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with flunisolide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with furosemide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with mefloquine.", "severity": 2}
{"drug1": "halothane", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with trandolapril.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Halobetasol.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Lornoxicam.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Olmesartan.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with loratadine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with Escitalopram.", "severity": 2}
{"drug1": "nabumetone", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with sulindac.", "severity": 2}
{"drug1": "valsartan", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with diflunisal.", "severity": 2}
{"drug1": "etodolac", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with scopolamine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with salicylic acid.", "severity": 2}
{"drug1": "etodolac", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with prednisone.", "severity": 2}
{"drug1": "baclofen", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Pipotiazine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Levocetirizine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Propiverine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with levodopa.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Perospirone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with butalbital.", "severity": 2}
{"drug1": "benzocaine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with phenytoin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with atorvastatin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with baclofen.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Perospirone.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Milnacipran.", "severity": 2}
{"drug1": "midazolam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Escitalopram.", "severity": 2}
{"drug1": "propofol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with brotizolam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with clidinium.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with nimesulide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dapagliflozin is combined with isoxsuprine.", "severity": 2}
{"drug1": "midazolam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with indapamide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with MELPERONE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with zotepine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Pomalidomide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with methoxyflurane.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with GUANFACINE.", "severity": 2}
{"drug1": "celecoxib", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with budesonide.", "severity": 2}
{"drug1": "thiopental", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with flunitrazepam.", "severity": 2}
{"drug1": "thiopental", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "duloxetine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with triflupromazine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with cyclophosphamide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with bumetanide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Drospirenone.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with methocarbamol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with proparacaine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with triprolidine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with nimesulide.", "severity": 2}
{"drug1": "estrone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with donepezil.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Tramadol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with duloxetine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with fluoxetine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with vinblastine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with pargyline.", "severity": 2}
{"drug1": "baclofen", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with clonidine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with thiothixene.", "severity": 2}
{"drug1": "thalidomide", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with indapamide.", "severity": 2}
{"drug1": "topiramate", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with doxepin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Olopatadine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "nicergoline", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with propofol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with acetazolamide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "cabergoline", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with doxepin.", "severity": 2}
{"drug1": "morphine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Normethadone.", "severity": 2}
{"drug1": "methysergide", "drug2": "Boceprevir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Boceprevir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with flurazepam.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with risperidone.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with hydrocortisone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with tenoxicam.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with rasagiline.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Ziprasidone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with quinidine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with homoharringtonine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with DEZOCINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with nabumetone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with ketorolac.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ethosuximide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with nifedipine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with papaverine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with AMILORIDE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with thiopental.", "severity": 2}
{"drug1": "cabergoline", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with prochlorperazine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with papaverine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nitric oxide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "diazoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with diazoxide.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with topiramate.", "severity": 2}
{"drug1": "oxycodone", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with DESFLURANE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with prilocaine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with estazolam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with loratadine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Articaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with chloral hydrate.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "furazolidone", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with dobutamine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Eplerenone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with methazolamide.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "morphine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with SUFENTANIL.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "morphine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nitric oxide.", "severity": 2}
{"drug1": "morphine", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with prochlorperazine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Boceprevir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Boceprevir.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with ethosuximide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with ondansetron.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with tiagabine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with cocaine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with zonisamide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with budesonide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Levetiracetam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with brotizolam.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Ketobemidone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with pravastatin.", "severity": 2}
{"drug1": "linezolid", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "linezolid", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with thiothixene.", "severity": 2}
{"drug1": "diclofenac", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with flurbiprofen.", "severity": 2}
{"drug1": "linezolid", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Pipotiazine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Perospirone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nimodipine.", "severity": 2}
{"drug1": "enalapril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with carisoprodol.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Methadyl acetate.", "severity": 2}
{"drug1": "quazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with tizanidine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with malathion.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with dantrolene.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with METAXALONE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with tubocurarine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with chlorthalidone.", "severity": 2}
{"drug1": "budesonide", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with nalidixic acid.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with chlorothiazide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with furosemide.", "severity": 2}
{"drug1": "budesonide", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with malathion.", "severity": 2}
{"drug1": "labetalol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Tramadol", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with proparacaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with Lercanidipine.", "severity": 2}
{"drug1": "quazepam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with nitrous oxide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with pimozide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with pramipexole.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with medrysone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with maprotiline.", "severity": 2}
{"drug1": "quazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Drospirenone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with carisoprodol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with methazolamide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with sulpiride.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with Deferasirox.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Flibanserin.", "severity": 2}
{"drug1": "topiramate", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with tiagabine.", "severity": 2}
{"drug1": "linezolid", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with sulpiride.", "severity": 2}
{"drug1": "imipramine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Bambuterol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Lornoxicam.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with methyldopa.", "severity": 2}
{"drug1": "imipramine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with clenbuterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with quinapril.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telithromycin is combined with toremifene.", "severity": 2}
{"drug1": "butabarbital", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with fluoxetine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with furosemide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Lercanidipine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with chlorprothixene.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with isoxsuprine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Iloperidone.", "severity": 2}
{"drug1": "pargyline", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with zotepine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with MELPERONE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Articaine.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Escitalopram.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Clodronic Acid.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with efavirenz.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Alvimopan.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with triflupromazine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with paroxetine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with spironolactone.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with procaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ritonavir.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with haloperidol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with sotalol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with acemetacin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "vindesine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with vindesine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Risedronic acid.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Bexarotene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Bexarotene.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Efonidipine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with mitomycin C.", "severity": 2}
{"drug1": "fosinopril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with flurbiprofen.", "severity": 2}
{"drug1": "Artemether", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with cilnidipine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Benidipine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Azelnidipine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Lacidipine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Efonidipine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with moclobemide.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with butalbital.", "severity": 2}
{"drug1": "zaleplon", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with fluvoxamine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Levomepromazine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "amifostine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with methyclothiazide.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with nifedipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with papaverine.", "severity": 2}
{"drug1": "clemastine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with scopolamine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with levorphanol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with perphenazine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Etidronic acid.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Pipotiazine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with papaverine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with nifedipine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "felodipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with norfloxacin.", "severity": 2}
{"drug1": "methysergide", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with midazolam.", "severity": 2}
{"drug1": "imipramine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Frovatriptan.", "severity": 2}
{"drug1": "valsartan", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Torasemide.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with codeine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Oxetacaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with nicotine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefloquine is combined with Cevimeline.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Lumiracoxib.", "severity": 2}
{"drug1": "reserpine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Bretylium.", "severity": 2}
{"drug1": "imipramine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "reserpine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with halothane.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with budesonide.", "severity": 2}
{"drug1": "sulindac", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with halcinonide.", "severity": 2}
{"drug1": "methysergide", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ciprofloxacin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with GUANFACINE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "methysergide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lovastatin is combined with atorvastatin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with rivastigmine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "pergolide", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with paramethasone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with physostigmine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with nimesulide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with fenbufen.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with flunarizine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "azelastine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with bromocriptine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with clonazepam.", "severity": 2}
{"drug1": "midazolam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with imipramine.", "severity": 2}
{"drug1": "promazine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Etomidate.", "severity": 2}
{"drug1": "atenolol", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with methyldopa.", "severity": 2}
{"drug1": "atenolol", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Telmisartan.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with betamethasone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with METAXALONE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with brotizolam.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with fenbufen.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with clonidine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with spironolactone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Carbetocin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with thiothixene.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Thioproperazine.", "severity": 2}
{"drug1": "metolazone", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with SERATRODAST.", "severity": 2}
{"drug1": "celiprolol", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with halcinonide.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with Abemaciclib.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Aceclofenac.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with zaltoprofen.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with difluprednate.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Loxoprofen.", "severity": 2}
{"drug1": "tiapride", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with tiagabine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with clomipramine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with venlafaxine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Retigabine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Ketobemidone.", "severity": 2}
{"drug1": "tiapride", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with zonisamide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with ambenonium.", "severity": 2}
{"drug1": "loratadine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with fexofenadine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with ethosuximide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with potassium ion.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methoxamine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with clenbuterol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ALFENTANIL.", "severity": 2}
{"drug1": "loxapine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with nortriptyline.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with barnidipine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with vigabatrin.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Nebivolol.", "severity": 2}
{"drug1": "butalbital", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with diflunisal.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Eprosartan.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with malathion.", "severity": 2}
{"drug1": "morphine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with triazolam.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Mephobarbital.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with nalidixic acid.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Palbociclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Palbociclib.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Flibanserin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with promethazine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with trimipramine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "estramustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with estramustine.", "severity": 2}
{"drug1": "promethazine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with bromocriptine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "naratriptan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with triflupromazine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with haloperidol.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with hydralazine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Ropivacaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with gabapentin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with buprenorphine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Olopatadine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "dicumarol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with dicumarol.", "severity": 2}
{"drug1": "prazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Drospirenone.", "severity": 2}
{"drug1": "butalbital", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Milnacipran.", "severity": 2}
{"drug1": "fosinopril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with suprofen.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with methscopolamine.", "severity": 2}
{"drug1": "temazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with butamben.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with ethosuximide.", "severity": 2}
{"drug1": "citalopram", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Fencamfamin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with NITROUS ACID.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with prednisone.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Tasimelteon.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with bifonazole.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with spironolactone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with medrysone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with DESONIDE.", "severity": 2}
{"drug1": "tiapride", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with topiramate.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with amoxapine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with glutethimide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with carisoprodol.", "severity": 2}
{"drug1": "benztropine", "drug2": "ethopropazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with ethopropazine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with sulpiride.", "severity": 2}
{"drug1": "triamterene", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Clevidipine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with efavirenz.", "severity": 2}
{"drug1": "prazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with brotizolam.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with SUFENTANIL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with trifluoperazine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with propoxyphene.", "severity": 2}
{"drug1": "cilazapril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with diclofenac.", "severity": 2}
{"drug1": "metolazone", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with nicardipine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with dantrolene.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Asenapine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BOPINDOLOL is combined with pilocarpine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Iloperidone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with nimesulide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with procaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with mirtazapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with procaine.", "severity": 2}
{"drug1": "promazine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with zonisamide.", "severity": 2}
{"drug1": "metolazone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "prazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with mesalamine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with citalopram.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Ciclesonide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Naftifine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dorzolamide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "buspirone", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with oxazepam.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Tasimelteon.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Normethadone.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with Pitavastatin.", "severity": 2}
{"drug1": "trazodone", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with dihydroergotamine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Tolcapone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Frovatriptan.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Flupentixol.", "severity": 2}
{"drug1": "labetalol", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with metaproterenol.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with enoxacin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Clevidipine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Cariprazine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with amisulpride.", "severity": 2}
{"drug1": "procaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with dantrolene.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "raloxifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with raloxifene.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Risedronic acid.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "warfarin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with warfarin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with DEZOCINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with mesoridazine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with zonisamide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Levetiracetam.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with oxybutynin.", "severity": 2}
{"drug1": "prednisone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with tubocurarine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perampanel is combined with Escitalopram.", "severity": 2}
{"drug1": "carprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with selegiline.", "severity": 2}
{"drug1": "carprofen", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with prednisone.", "severity": 2}
{"drug1": "propofol", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with minoxidil.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Tasimelteon.", "severity": 2}
{"drug1": "haloperidol", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with tetracaine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with isoproterenol.", "severity": 2}
{"drug1": "propofol", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with chlorzoxazone.", "severity": 2}
{"drug1": "timolol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with losartan.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with manidipine.", "severity": 2}
{"drug1": "propofol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with betaxolol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with fenbufen.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with spironolactone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with methocarbamol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with fluvastatin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with ibuprofen.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with triprolidine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with felbamate.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with tretinoin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with isoflurane.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with sulindac.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with loteprednol.", "severity": 2}
{"drug1": "loxapine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with nalbuphine.", "severity": 2}
{"drug1": "loxapine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with oxazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with nitrous oxide.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with desipramine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "risperidone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with benzocaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Mephobarbital.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Tolcapone.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nadolol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Nitroprusside.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with desoximetasone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Riociguat.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Oxetacaine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ergocalciferol is combined with Calcipotriol.", "severity": 2}
{"drug1": "etodolac", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Efonidipine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with dexamethasone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Levalbuterol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "benazepril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with epirizole.", "severity": 2}
{"drug1": "fosinopril", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with captopril.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with AMILORIDE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with ethosuximide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with doxazosin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Deferasirox.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Sacubitril.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with thiopental.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with labetalol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with perphenazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with flunarizine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Desloratadine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Butethal.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "OXCARBAZEPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with cinoxacin.", "severity": 2}
{"drug1": "propofol", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with dipyridamole.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Aceclofenac.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Milnacipran.", "severity": 2}
{"drug1": "Salsalate", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with flurandrenolide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with budesonide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with nitroglycerin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with MELPERONE.", "severity": 2}
{"drug1": "Butethal", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with loratadine.", "severity": 2}
{"drug1": "Butethal", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with imipramine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with clonazepam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Levocetirizine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with butamben.", "severity": 2}
{"drug1": "miconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with clonidine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with nimesulide.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with nimodipine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with zotepine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with MELPERONE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with sulfasalazine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with pilocarpine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with felodipine.", "severity": 2}
{"drug1": "temazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with trimipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with trimipramine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with enalapril.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Tianeptine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with procaine.", "severity": 2}
{"drug1": "labetalol", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with felodipine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with chlorothiazide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Oxetacaine.", "severity": 2}
{"drug1": "labetalol", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with irbesartan.", "severity": 2}
{"drug1": "isoflurane", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with trandolapril.", "severity": 2}
{"drug1": "clorazepate", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with sertraline.", "severity": 2}
{"drug1": "tizanidine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with indapamide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with flunisolide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Bendamustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Bendamustine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with clonidine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with clidinium.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with methocarbamol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Retigabine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with alclometasone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with dexamethasone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Pipotiazine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with topiramate.", "severity": 2}
{"drug1": "dibucaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "dibucaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with flunarizine.", "severity": 2}
{"drug1": "loxapine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with vigabatrin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Zoledronic acid.", "severity": 2}
{"drug1": "meclizine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with indapamide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Droxicam", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Asenapine.", "severity": 2}
{"drug1": "linezolid", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with Levomepromazine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with niflumic acid.", "severity": 2}
{"drug1": "alprazolam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Zoledronic acid.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with amisulpride.", "severity": 2}
{"drug1": "acemetacin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with promethazine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with levodopa.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pomalidomide is combined with Milnacipran.", "severity": 2}
{"drug1": "azelastine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with antipyrine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with dibucaine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Fesoterodine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Pimecrolimus.", "severity": 2}
{"drug1": "valsartan", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with atenolol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Flibanserin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with thiothixene.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with penbutolol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Pipotiazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Quinupristin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Ramelteon.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Empagliflozin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with isoxsuprine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "promazine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with trifluoperazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with floctafenine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with phenmetrazine.", "severity": 2}
{"drug1": "ketamine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with PROCATEROL.", "severity": 2}
{"drug1": "trandolapril", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with metolazone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with carisoprodol.", "severity": 2}
{"drug1": "codeine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with oxycodone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "gabapentin", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with oxprenolol.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with sulfasalazine.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with methscopolamine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with clemastine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with fludrocortisone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with venlafaxine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with MELPERONE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with salicylamide.", "severity": 2}
{"drug1": "halothane", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Propoxycaine.", "severity": 2}
{"drug1": "selegiline", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with nitroglycerin.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with Escitalopram.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Clodronic Acid.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with prochlorperazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with zonisamide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Phenelzine.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cilastatin is combined with cyclophosphamide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Ramelteon.", "severity": 2}
{"drug1": "pergolide", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with rapamycin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with chlorprothixene.", "severity": 2}
{"drug1": "tretinoin", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with carvedilol.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with dantrolene.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with ouabain.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with citalopram.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with minoxidil.", "severity": 2}
{"drug1": "butabarbital", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with amitriptyline.", "severity": 2}
{"drug1": "butabarbital", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with hydromorphone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Clevidipine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with zonisamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with suprofen.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Difenoxin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with tiagabine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Perospirone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with ketoprofen.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Etomidate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with tizanidine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Almotriptan.", "severity": 2}
{"drug1": "clozapine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with morphine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with trifluoperazine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with sulindac.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with clonidine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Posaconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Posaconazole.", "severity": 2}
{"drug1": "Halazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with triprolidine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with equilin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "codeine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Escitalopram.", "severity": 2}
{"drug1": "loteprednol", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Fluspirilene.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with oxycodone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Perospirone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Milnacipran.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with DESONIDE.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with chlorpheniramine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with methazolamide.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ropinirole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with tizanidine.", "severity": 2}
{"drug1": "clozapine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with D-mannitol.", "severity": 2}
{"drug1": "cocaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Fospropofol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Flibanserin.", "severity": 2}
{"drug1": "isradipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "clozapine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with scopolamine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with maprotiline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with terbutaline.", "severity": 2}
{"drug1": "pergolide", "drug2": "diethylstilbestrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "aspirin", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with epirizole.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with fexofenadine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Fluprednidene.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Salsalate.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with sulfasalazine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with nalbuphine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with salicylamide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with dibucaine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with cilazapril.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with glutethimide.", "severity": 2}
{"drug1": "procaine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Mephobarbital.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with rasagiline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with maprotiline.", "severity": 2}
{"drug1": "methadone", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Paliperidone.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with pentazocine.", "severity": 2}
{"drug1": "etodolac", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with mycophenolic acid.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Pizotifen.", "severity": 2}
{"drug1": "cerulenin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with manidipine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with CLONIXIN.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with gabapentin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with tolfenamic acid.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Droxicam.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Loxoprofen.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Etomidate.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with carisoprodol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with sulpiride.", "severity": 2}
{"drug1": "isoflurane", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with MOLINDONE.", "severity": 2}
{"drug1": "enflurane", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Agomelatine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Ramelteon.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with tetracaine.", "severity": 2}
{"drug1": "eperisone", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with Pitavastatin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Aliskiren.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Ramelteon.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with donepezil.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "gabapentin", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with ropinirole.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with alclofenac.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Agomelatine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with dexamethasone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with levodopa.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with metoprolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "penbutolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with formestane.", "severity": 2}
{"drug1": "buspirone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with nitrendipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Methadyl acetate.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with oxprenolol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with glutethimide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Dimethyl fumarate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Dimethyl fumarate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Flibanserin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with cisapride.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Levocetirizine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Lofexidine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Tramadol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Drospirenone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with tretinoin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with cetirizine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with primidone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with protriptyline.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Teriflunomide.", "severity": 2}
{"drug1": "periciazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when periciazine is combined with olanzapine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with niflumic acid.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with fluvastatin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Fluprednidene.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with sulpiride.", "severity": 2}
{"drug1": "reserpine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "reserpine", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with tizanidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with furosemide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with HEROIN.", "severity": 2}
{"drug1": "NALDEMEDINE", "drug2": "Naloxegol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NALDEMEDINE is combined with Naloxegol.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with propoxyphene.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with reserpine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Lacidipine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Efonidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Tolcapone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with thiothixene.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Risedronic acid.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Pipotiazine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with fludiazepam.", "severity": 2}
{"drug1": "bifonazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with manidipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with procaine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with apraclonidine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with butalbital.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with trimipramine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Nebivolol.", "severity": 2}
{"drug1": "estazolam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with paroxetine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with aspirin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with irbesartan.", "severity": 2}
{"drug1": "nabumetone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with GUANFACINE.", "severity": 2}
{"drug1": "promazine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with prilocaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with fexofenadine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with enflurane.", "severity": 2}
{"drug1": "prazepam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with sertraline.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with carvedilol.", "severity": 2}
{"drug1": "nadolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with quetiapine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with butalbital.", "severity": 2}
{"drug1": "barnidipine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with clomipramine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with epoprostenol.", "severity": 2}
{"drug1": "barnidipine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with isocarboxazid.", "severity": 2}
{"drug1": "barnidipine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with bepridil.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with efavirenz.", "severity": 2}
{"drug1": "buspirone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "pentazocine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "codeine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with quetiapine.", "severity": 2}
{"drug1": "buspirone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with oxprenolol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with flunisolide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with resveratrol.", "severity": 2}
{"drug1": "buspirone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with prazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with butorphanol.", "severity": 2}
{"drug1": "meperidine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with penbutolol.", "severity": 2}
{"drug1": "loxapine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with promethazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with baclofen.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with amcinonide.", "severity": 2}
{"drug1": "diazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with promethazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with gabapentin.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Demecarium.", "severity": 2}
{"drug1": "diazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Melatonin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Apremilast.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with methscopolamine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Flupentixol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with terazosin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with estazolam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with trazodone.", "severity": 2}
{"drug1": "butalbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with Metixene.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with nicardipine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with metolazone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with flumethasone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "antipyrine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "salicylamide", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with fenbufen.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Sacubitril.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with thalidomide.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Crizotinib is combined with atorvastatin.", "severity": 2}
{"drug1": "meperidine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with loratadine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Ropivacaine.", "severity": 2}
{"drug1": "meperidine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with imipramine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyphylline is combined with Indacaterol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with mepivacaine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with ketoprofen.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "pentoxifylline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with pentoxifylline.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with clonazepam.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with butalbital.", "severity": 2}
{"drug1": "baclofen", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with GUANFACINE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Desloratadine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Melatonin.", "severity": 2}
{"drug1": "methysergide", "drug2": "josamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with josamycin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with dyclonine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with diclofenac.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with proparacaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Halazepam.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Capsaicin.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with aspirin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with meclofenamic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Icatibant.", "severity": 2}
{"drug1": "morphine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Iloperidone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with VERAPAMIL.", "severity": 2}
{"drug1": "ritonavir", "drug2": "disulfiram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritonavir is combined with disulfiram.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with bromocriptine.", "severity": 2}
{"drug1": "morphine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with thiothixene.", "severity": 2}
{"drug1": "furosemide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with isoxsuprine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with fenoprofen.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with acebutolol.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with paramethasone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with VERAPAMIL.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Etidronic acid.", "severity": 2}
{"drug1": "prazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Riociguat.", "severity": 2}
{"drug1": "Tramadol", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with nitrous oxide.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with Risedronic acid.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Ramelteon.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with tubocurarine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with ethosuximide.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with mecamylamine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Iloperidone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Pizotifen.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with nitroglycerin.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Aliskiren.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with Pitavastatin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Milnacipran.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Icatibant.", "severity": 2}
{"drug1": "timolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with pilocarpine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with dantrolene.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Ciclesonide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with indapamide.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with zotepine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with MELPERONE.", "severity": 2}
{"drug1": "hexetidine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with nifedipine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Demecarium.", "severity": 2}
{"drug1": "leflunomide", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with flumethasone.", "severity": 2}
{"drug1": "enalapril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with mefloquine.", "severity": 2}
{"drug1": "thiopental", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with benzocaine.", "severity": 2}
{"drug1": "thiopental", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with vigabatrin.", "severity": 2}
{"drug1": "HEROIN", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with cyclothiazide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chlorthalidone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with prednisone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flibanserin is combined with Pizotifen.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with maprotiline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with Escitalopram.", "severity": 2}
{"drug1": "diclofenac", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with mefenamic acid.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with ibuprofen.", "severity": 2}
{"drug1": "clonidine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Difenoxin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Tolcapone.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with amitriptyline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with cisapride.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Pipamperone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with chlorprothixene.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Aripiprazole.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with sevoflurane.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with levodopa.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with carisoprodol.", "severity": 2}
{"drug1": "cocaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Articaine.", "severity": 2}
{"drug1": "atenolol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with triamterene.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Alitretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlortetracycline is combined with Alitretinoin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Vecuronium.", "severity": 2}
{"drug1": "zonisamide", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with doxepin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Levocetirizine.", "severity": 2}
{"drug1": "carprofen", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with azelastine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with cyclopentolate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with edrophonium.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with trandolapril.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with procaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with amisulpride.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with rivastigmine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with CYCLIZINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with dantrolene.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with physostigmine.", "severity": 2}
{"drug1": "imipramine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with glutethimide.", "severity": 2}
{"drug1": "promazine", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with diazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with irbesartan.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with enalapril.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with AMILORIDE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with tiagabine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with felodipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with prilocaine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Nebivolol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with tizanidine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with butamben.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Propacetamol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with triamterene.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with MELPERONE.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with D-mannitol.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with physostigmine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Mometasone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with penbutolol.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with rivastigmine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Loxoprofen.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Icatibant.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Droxicam.", "severity": 2}
{"drug1": "sertraline", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with doxepin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with toremifene.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Nitroprusside.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Erlotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Erlotinib.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "ciprofloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with ciprofloxacin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NEOSTIGMINE is combined with Carbamylcholine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Paliperidone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with venlafaxine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with celecoxib.", "severity": 2}
{"drug1": "butorphanol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with chloral hydrate.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with pirenzepine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with isradipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Metipranolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Olmesartan.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Telmisartan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "procaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Butethal.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with dantrolene.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Ramelteon.", "severity": 2}
{"drug1": "reserpine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Clevidipine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with manidipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "leflunomide", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with loteprednol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when physostigmine is combined with Carbamylcholine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Benidipine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Azelnidipine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with tetracaine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with niflumic acid.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with moclobemide.", "severity": 2}
{"drug1": "methadone", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Mersalyl.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with paramethasone.", "severity": 2}
{"drug1": "methadone", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Ketobemidone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Bortezomib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Varenicline.", "severity": 2}
{"drug1": "rapamycin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "azelastine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "procarbazine", "drug2": "promazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with promazine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with ESMOLOL.", "severity": 2}
{"drug1": "Asenapine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with dantrolene.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Cevimeline.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nicotine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Tasimelteon.", "severity": 2}
{"drug1": "Naftifine", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with bepridil.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with Deferasirox.", "severity": 2}
{"drug1": "Naftifine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with eperisone.", "severity": 2}
{"drug1": "carprofen", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with ketoprofen.", "severity": 2}
{"drug1": "resveratrol", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "estazolam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with flunarizine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with sulfasalazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with paroxetine.", "severity": 2}
{"drug1": "promazine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Aceclofenac.", "severity": 2}
{"drug1": "Naftifine", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with zaltoprofen.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with paroxetine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with nisoldipine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with procarbazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "promazine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Retigabine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with homoharringtonine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with SERATRODAST.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with nimodipine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with carisoprodol.", "severity": 2}
{"drug1": "meperidine", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with D-mannitol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with thiamylal.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with desipramine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with halothane.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with oxprenolol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Remoxipride.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with metronidazole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Repaglinide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with etizolam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with halcinonide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with clidinium.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with acemetacin.", "severity": 2}
{"drug1": "losartan", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Empagliflozin.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with morphine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Vecuronium.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Ramelteon.", "severity": 2}
{"drug1": "warfarin", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when warfarin is combined with Nintedanib.", "severity": 2}
{"drug1": "isoflurane", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with reserpine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with trimipramine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Propacetamol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with thiothixene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Pipotiazine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "clonidine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with vigabatrin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "L-phenylalanine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with L-phenylalanine.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with nefazodone.", "severity": 2}
{"drug1": "clidinium", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with CYCLIZINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Lurasidone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with doxepin.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with DEZOCINE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Aripiprazole.", "severity": 2}
{"drug1": "etizolam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with doxepin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with imipramine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with prazosin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with methazolamide.", "severity": 2}
{"drug1": "clidinium", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Escitalopram.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with DEZOCINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Drospirenone.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Levetiracetam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with quetiapine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with Pomalidomide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with resveratrol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with atorvastatin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with ethosuximide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Atazanavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Atazanavir.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Deferasirox.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with pimozide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "timolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with floctafenine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with thiopental.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Deferasirox.", "severity": 2}
{"drug1": "prilocaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with fluoxetine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Olopatadine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Escitalopram.", "severity": 2}
{"drug1": "prilocaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with duloxetine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with acemetacin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with MELPERONE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with zotepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "desipramine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with Pizotifen.", "severity": 2}
{"drug1": "propofol", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nalbuphine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Metipranolol.", "severity": 2}
{"drug1": "zaleplon", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with mepivacaine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "secobarbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with vigabatrin.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with nilvadipine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "loxapine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with METAXALONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with mycophenolic acid.", "severity": 2}
{"drug1": "zopiclone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "triazolam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with sertraline.", "severity": 2}
{"drug1": "Quinupristin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Quinupristin is combined with atorvastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with pimozide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with chloral hydrate.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with chlorzoxazone.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with CYCLIZINE.", "severity": 2}
{"drug1": "procaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with benzocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Escitalopram.", "severity": 2}
{"drug1": "lorazepam", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with benzocaine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with diflunisal.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with alclofenac.", "severity": 2}
{"drug1": "lorazepam", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with vigabatrin.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with zotepine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with MELPERONE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with atorvastatin.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with amoxapine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with antipyrine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with meclizine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Tolvaptan.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "apomorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with apomorphine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Asenapine.", "severity": 2}
{"drug1": "Butethal", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with topiramate.", "severity": 2}
{"drug1": "folinic acid", "drug2": "CAPECITABINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when folinic acid is combined with CAPECITABINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with chloral hydrate.", "severity": 2}
{"drug1": "tolazoline", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with nitroglycerin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with nalidixic acid.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with dipyridamole.", "severity": 2}
{"drug1": "levorphanol", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with polythiazide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Levocetirizine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Tixocortol.", "severity": 2}
{"drug1": "clemastine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Pizotifen.", "severity": 2}
{"drug1": "fenbufen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with budesonide.", "severity": 2}
{"drug1": "HEROIN", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with dantrolene.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Aliskiren.", "severity": 2}
{"drug1": "cilostazol", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with mesalamine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with gabapentin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Flibanserin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with amoxapine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with nortriptyline.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with fluocinonide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with levodopa.", "severity": 2}
{"drug1": "chloroquine", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with aspirin.", "severity": 2}
{"drug1": "etizolam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with clozapine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with MOLINDONE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Temsirolimus.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Thioproperazine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with thiothixene.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Pizotifen.", "severity": 2}
{"drug1": "isradipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with spironolactone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Salsalate.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with gabapentin.", "severity": 2}
{"drug1": "proparacaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with amitriptyline.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Tolcapone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with Demecarium.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "triazolam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with topiramate.", "severity": 2}
{"drug1": "quinapril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with azelastine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with clofazimine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Fluprednidene.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with pyridostigmine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Teriflunomide.", "severity": 2}
{"drug1": "thiopental", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with prazepam.", "severity": 2}
{"drug1": "sertraline", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Pipamperone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with fludiazepam.", "severity": 2}
{"drug1": "sertraline", "drug2": "Tianeptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Tianeptine.", "severity": 2}
{"drug1": "prednisone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with edrophonium.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with terbutaline.", "severity": 2}
{"drug1": "ramipril", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with metolazone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "floctafenine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with fluocinonide.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with paroxetine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with GUANFACINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with methoxyflurane.", "severity": 2}
{"drug1": "Icatibant", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "halothane", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Iloperidone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Fencamfamin.", "severity": 2}
{"drug1": "codeine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chlorothiazide.", "severity": 2}
{"drug1": "codeine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with bumetanide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nicardipine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Etidocaine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with diflunisal.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Tolcapone.", "severity": 2}
{"drug1": "quazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with etizolam.", "severity": 2}
{"drug1": "doxycycline", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with ADAPALENE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with diflorasone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with diflunisal.", "severity": 2}
{"drug1": "lithium ion", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "codeine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Phenelzine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with leflunomide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Methadyl acetate.", "severity": 2}
{"drug1": "meperidine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Flupentixol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Etidocaine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Regorafenib.", "severity": 2}
{"drug1": "clomipramine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with meclizine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Ethylmorphine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Fencamfamin.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Fluprednidene.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Aceclofenac.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with zaltoprofen.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with triflupromazine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Desloratadine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with haloperidol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with SERATRODAST.", "severity": 2}
{"drug1": "halothane", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with hydralazine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Carbetocin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with topiramate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Hexobarbital.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Levomepromazine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Olsalazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with danazol.", "severity": 2}
{"drug1": "pimozide", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Fencamfamin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Prasugrel is combined with salicylic acid.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with quazepam.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with prazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with morphine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Teriflunomide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with nefazodone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Salsalate.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Mometasone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with Clevidipine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with nifedipine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with bumetanide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with cyclophosphamide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with morphine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with meclizine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with isocarboxazid.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with metolazone.", "severity": 2}
{"drug1": "dopamine", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dopamine is combined with celiprolol.", "severity": 2}
{"drug1": "ritodrine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with Escitalopram.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Loxoprofen.", "severity": 2}
{"drug1": "celecoxib", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with diflorasone.", "severity": 2}
{"drug1": "amisulpride", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with topiramate.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with pramipexole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with nitrazepam.", "severity": 2}
{"drug1": "Metixene", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Ethylmorphine.", "severity": 2}
{"drug1": "meperidine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with butorphanol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Deferasirox.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with irbesartan.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Midostaurin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Midostaurin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with amisulpride.", "severity": 2}
{"drug1": "temazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with clomipramine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with felodipine.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Tasimelteon.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with papaverine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Iloperidone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Melatonin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Clofarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Clofarabine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Flupentixol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with promethazine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with clonazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with dantrolene.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "indapamide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Masoprocol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "morphine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Tasimelteon.", "severity": 2}
{"drug1": "acemetacin", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with dexamethasone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with alclofenac.", "severity": 2}
{"drug1": "risperidone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "risperidone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with flunitrazepam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Torasemide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with digoxin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with sulpiride.", "severity": 2}
{"drug1": "methadone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ethotoin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Oxetacaine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Cariprazine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ESMOLOL.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with baclofen.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium citrate is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with sulindac.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Clodronic Acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with methylprednisolone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with topiramate.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Levobupivacaine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with prazosin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with loratadine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "ondansetron", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with flurandrenolide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with sparfloxacin.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with imipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with clonidine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "trimipramine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with dantrolene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with dyclonine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Fencamfamin.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with papaverine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with tiagabine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with nifedipine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Clevidipine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Metipranolol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Pipamperone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with epirizole.", "severity": 2}
{"drug1": "methazolamide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "prilocaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with meclizine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Normethadone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with estazolam.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with prazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with triazolam.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with thiopental.", "severity": 2}
{"drug1": "bupropion", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupropion is combined with paroxetine.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with triprolidine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with selegiline.", "severity": 2}
{"drug1": "gabapentin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "indapamide", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with carbamazepine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Propacetamol.", "severity": 2}
{"drug1": "thiopental", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Tasimelteon.", "severity": 2}
{"drug1": "pergolide", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with anastrozole.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Lormetazepam.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with trimipramine.", "severity": 2}
{"drug1": "atenolol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "temazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with efavirenz.", "severity": 2}
{"drug1": "felbamate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with GUANFACINE.", "severity": 2}
{"drug1": "Trospium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with hydromorphone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Tadalafil.", "severity": 2}
{"drug1": "temazepam", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "epirizole", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with prednisone.", "severity": 2}
{"drug1": "epirizole", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "pergolide", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with pilocarpine.", "severity": 2}
{"drug1": "pergolide", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with nimesulide.", "severity": 2}
{"drug1": "nystatin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with nimesulide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with SERATRODAST.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with penbutolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with triflupromazine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with SERTINDOLE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Aceclofenac.", "severity": 2}
{"drug1": "zopiclone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with tranylcypromine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with HEROIN.", "severity": 2}
{"drug1": "zopiclone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with prilocaine.", "severity": 2}
{"drug1": "morphine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with indapamide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with ethotoin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Teriflunomide.", "severity": 2}
{"drug1": "morphine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Halazepam.", "severity": 2}
{"drug1": "betaxolol", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with triamterene.", "severity": 2}
{"drug1": "pimozide", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Remoxipride.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with triprolidine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Canagliflozin is combined with Empagliflozin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with oxprenolol.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Olsalazine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Pizotifen.", "severity": 2}
{"drug1": "etodolac", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with fludiazepam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with theobromine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with amisulpride.", "severity": 2}
{"drug1": "lithium ion", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with loratadine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with meclizine.", "severity": 2}
{"drug1": "desipramine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with clenbuterol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with flurazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with paroxetine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Fosphenytoin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Etomidate.", "severity": 2}
{"drug1": "glutethimide", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with phenytoin.", "severity": 2}
{"drug1": "pergolide", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with ondansetron.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Ropivacaine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with bupivacaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with diltiazem.", "severity": 2}
{"drug1": "citalopram", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with naratriptan.", "severity": 2}
{"drug1": "midazolam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with zonisamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with thiopental.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with ethosuximide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with loxapine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with flunarizine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Clobetasone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with felodipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with tioconazole.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with irbesartan.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with pargyline.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Iloperidone.", "severity": 2}
{"drug1": "captopril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "diazepam", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with cocaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with tiagabine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with niflumic acid.", "severity": 2}
{"drug1": "diazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with zonisamide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Pipotiazine.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with fluoxetine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with losartan.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with duloxetine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with hydrocortisone.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with dantrolene.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with periciazine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with fludiazepam.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "mechlorethamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with mechlorethamine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Aripiprazole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Etidocaine.", "severity": 2}
{"drug1": "codeine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with prilocaine.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with Ciclesonide.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with thiopental.", "severity": 2}
{"drug1": "alclofenac", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with flurandrenolide.", "severity": 2}
{"drug1": "diflunisal", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with diflorasone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with tiapride.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with pentazocine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "butenafine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Calcium acetate is combined with Paricalcitol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with nifedipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with carisoprodol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with sevoflurane.", "severity": 2}
{"drug1": "methysergide", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with loratadine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Flibanserin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Olopatadine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with citalopram.", "severity": 2}
{"drug1": "lithium ion", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with HEROIN.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with reserpine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Propacetamol.", "severity": 2}
{"drug1": "quinapril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Etoricoxib.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "quinapril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Empagliflozin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with sparfloxacin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with tizanidine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with resveratrol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Propiverine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Agomelatine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with methyldopa.", "severity": 2}
{"drug1": "diflunisal", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Halobetasol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with timolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Sacubitril.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with donepezil.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BUPRANOLOL is combined with acetylcholine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with ESMOLOL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with triamterene.", "severity": 2}
{"drug1": "lorazepam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with citalopram.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with triamcinolone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nortriptyline.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with clidinium.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with simvastatin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with rabeprazole.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with dipyridamole.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with acebutolol.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Telmisartan.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with apraclonidine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with captopril.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with methyldopa.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with tofisopam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with chloral hydrate.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with metoclopramide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with amoxapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Eslicarbazepine acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with chlorprothixene.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Aripiprazole.", "severity": 2}
{"drug1": "diazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with topiramate.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Fesoterodine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with Clevidipine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with clomipramine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Carbetocin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with meclizine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Propiverine.", "severity": 2}
{"drug1": "biperiden", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Metixene.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Levobupivacaine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with Difenoxin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with halcinonide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Salbutamol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Eplerenone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with edrophonium.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with selegiline.", "severity": 2}
{"drug1": "cetirizine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with methocarbamol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with simvastatin.", "severity": 2}
{"drug1": "Trospium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with procarbazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "oxazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with glutethimide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with furosemide.", "severity": 2}
{"drug1": "cetirizine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with triprolidine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with tizanidine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "paramethasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with fleroxacin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with phentolamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with chlorthalidone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with acetaminophen.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with betamethasone.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Levetiracetam.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with acebutolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Canagliflozin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with MELPERONE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Levobupivacaine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "flecainide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with flecainide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with phenytoin.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Flibanserin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with nalbuphine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Ramelteon.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with leflunomide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with nimodipine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with azelastine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with nalbuphine.", "severity": 2}
{"drug1": "methadone", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with gabapentin.", "severity": 2}
{"drug1": "methadone", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Frovatriptan.", "severity": 2}
{"drug1": "temazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with clonazepam.", "severity": 2}
{"drug1": "ketorolac", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ranitidine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with sertraline.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Tasimelteon.", "severity": 2}
{"drug1": "naratriptan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with mesoridazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with tiapride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with procarbazine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "thiothixene", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with flunitrazepam.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with Spirapril.", "severity": 2}
{"drug1": "Articaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with methyldopa.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with halcinonide.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with tubocurarine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with quetiapine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with cilazapril.", "severity": 2}
{"drug1": "Articaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "trazodone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with efavirenz.", "severity": 2}
{"drug1": "primidone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with thiamylal.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with meclofenamic acid.", "severity": 2}
{"drug1": "furazolidone", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with OLODATEROL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Fospropofol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with Vilanterol.", "severity": 2}
{"drug1": "sulindac", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with mefenamic acid.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ixabepilone is combined with clozapine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Gemifloxacin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Milnacipran.", "severity": 2}
{"drug1": "Melatonin", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with etizolam.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with chlorthalidone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with memantine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with methocarbamol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with buspirone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with glutethimide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with oxycodone.", "severity": 2}
{"drug1": "midazolam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with MOLINDONE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with decamethonium.", "severity": 2}
{"drug1": "linezolid", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with SERTINDOLE.", "severity": 2}
{"drug1": "trazodone", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Tramadol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with salicylamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with prazepam.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with orphenadrine.", "severity": 2}
{"drug1": "atenolol", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with sotalol.", "severity": 2}
{"drug1": "thiopental", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Iloperidone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Capsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Capsaicin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with penbutolol.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with diflorasone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Pizotifen.", "severity": 2}
{"drug1": "thiopental", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with phenytoin.", "severity": 2}
{"drug1": "estrone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with enoxacin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with budesonide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with topotecan.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with tranylcypromine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Risedronic acid.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with oxprenolol.", "severity": 2}
{"drug1": "quazepam", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with ethchlorvynol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Salsalate.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with SUFENTANIL.", "severity": 2}
{"drug1": "quazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with baclofen.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with isoflurane.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Apremilast.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with tretinoin.", "severity": 2}
{"drug1": "dyclonine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with brotizolam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "terconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with eperisone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with alclofenac.", "severity": 2}
{"drug1": "lisinopril", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with indomethacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Levocetirizine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Etidocaine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with chlorprothixene.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with prazepam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with isoxsuprine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Nebivolol.", "severity": 2}
{"drug1": "dapsone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Milnacipran.", "severity": 2}
{"drug1": "isradipine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with indapamide.", "severity": 2}
{"drug1": "Trospium", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "quazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with loratadine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with formestane.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Lormetazepam.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with promethazine.", "severity": 2}
{"drug1": "linezolid", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with sumatriptan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with PROCATEROL.", "severity": 2}
{"drug1": "clonidine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Retigabine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "codeine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with protriptyline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with butamben.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "gemcitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with gemcitabine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with betamethasone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Epirubicin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with teniposide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with D-mannitol.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Difenoxin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Flibanserin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with tetracaine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with scopolamine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Etidronic acid.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with dipyridamole.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with SERTINDOLE.", "severity": 2}
{"drug1": "estazolam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Pomalidomide.", "severity": 2}
{"drug1": "imipramine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with timolol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with fludrocortisone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with sparfloxacin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cinnarizine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with trandolapril.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Levalbuterol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with quetiapine.", "severity": 2}
{"drug1": "budesonide", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with enoxacin.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with loratadine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Deferasirox.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Agomelatine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "scopolamine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with clonidine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Pipotiazine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with selegiline.", "severity": 2}
{"drug1": "methadone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with vigabatrin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Aceprometazine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with niflumic acid.", "severity": 2}
{"drug1": "ipratropium", "drug2": "hyoscyamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with hyoscyamine.", "severity": 2}
{"drug1": "reserpine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with quazepam.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Pipamperone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with dantrolene.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with apraclonidine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with MOLINDONE.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with nefazodone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Pramocaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Propoxycaine.", "severity": 2}
{"drug1": "methysergide", "drug2": "sulfanilamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with sulfanilamide.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with doxepin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Salbutamol.", "severity": 2}
{"drug1": "amifostine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with methadone.", "severity": 2}
{"drug1": "buspirone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "loratadine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with zonisamide.", "severity": 2}
{"drug1": "aspirin", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Etoricoxib.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with paroxetine.", "severity": 2}
{"drug1": "methysergide", "drug2": "doxycycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with doxycycline.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with clomipramine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with propofol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with acetazolamide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Ramelteon.", "severity": 2}
{"drug1": "triazolam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with chlorprothixene.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with hydrocortisone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with mianserin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with isoflurane.", "severity": 2}
{"drug1": "oxycodone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with prilocaine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with hydromorphone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with thiamylal.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ethotoin.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with haloperidol.", "severity": 2}
{"drug1": "trapidil", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with salicylic acid.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with ZILEUTON.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with triflupromazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with irbesartan.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with triamcinolone.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with deslanoside.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Etidocaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with thiothixene.", "severity": 2}
{"drug1": "imipramine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with felodipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with clonidine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with scopolamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "azelastine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Tixocortol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with triamterene.", "severity": 2}
{"drug1": "lisinopril", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Elbasvir is combined with atorvastatin.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with fexofenadine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with fluocinonide.", "severity": 2}
{"drug1": "enalapril", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "felodipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with halcinonide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Fospropofol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Droxicam.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with edrophonium.", "severity": 2}
{"drug1": "secobarbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Loxoprofen.", "severity": 2}
{"drug1": "tropicamide", "drug2": "propantheline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with propantheline.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with fludiazepam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with primidone.", "severity": 2}
{"drug1": "valsartan", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Mometasone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Pefloxacin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipotiazine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with methimazole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with irinotecan.", "severity": 2}
{"drug1": "clonidine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with methyldopa.", "severity": 2}
{"drug1": "clidinium", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Lorcaserin.", "severity": 2}
{"drug1": "procyclidine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "Pemetrexed", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pemetrexed is combined with clozapine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Lurasidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with medrysone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with celecoxib.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with CARTEOLOL.", "severity": 2}
{"drug1": "pimozide", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Articaine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with scopolamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with amobarbital.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "sulfisoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with sulfisoxazole.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with trifluoperazine.", "severity": 2}
{"drug1": "clozapine", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with phentolamine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with captopril.", "severity": 2}
{"drug1": "haloprogin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with nicardipine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with CLONIXIN.", "severity": 2}
{"drug1": "chloroquine", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with mefloquine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Hexobarbital.", "severity": 2}
{"drug1": "Torasemide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with penbutolol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Etoricoxib.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with medrysone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Estrone sulfate.", "severity": 2}
{"drug1": "dantrolene", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dantrolene is combined with levodopa.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with METAXALONE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with tiagabine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with zonisamide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Levomilnacipran.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Tasimelteon.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with triamcinolone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Mometasone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with efavirenz.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with meclizine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with CLONIXIN.", "severity": 2}
{"drug1": "haloprogin", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with gabapentin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Droxicam.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with codeine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with digitoxin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with indapamide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with butamben.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with butamben.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with naratriptan.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Icatibant.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with quazepam.", "severity": 2}
{"drug1": "prazepam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with zonisamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with tolfenamic acid.", "severity": 2}
{"drug1": "proparacaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with methocarbamol.", "severity": 2}
{"drug1": "prazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with tiagabine.", "severity": 2}
{"drug1": "zotepine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with clemastine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with triprolidine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with losartan.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "zotepine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Flibanserin.", "severity": 2}
{"drug1": "malathion", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when malathion is combined with Carbamylcholine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with dantrolene.", "severity": 2}
{"drug1": "Etomidate", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with benzocaine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Iloperidone.", "severity": 2}
{"drug1": "midodrine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with ritodrine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with dyclonine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with fenbufen.", "severity": 2}
{"drug1": "Butethal", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with clonazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with promethazine.", "severity": 2}
{"drug1": "loxapine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with phenytoin.", "severity": 2}
{"drug1": "metolazone", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with indapamide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with oxprenolol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "oxycodone", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with propoxyphene.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with ethotoin.", "severity": 2}
{"drug1": "sotalol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with bumetanide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with quazepam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with prazepam.", "severity": 2}
{"drug1": "levorphanol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with prilocaine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Masoprocol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with tranylcypromine.", "severity": 2}
{"drug1": "sotalol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with quinapril.", "severity": 2}
{"drug1": "cocaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "baclofen", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "baclofen", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Ramelteon.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with tiapride.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Normethadone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with azelastine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with triflupromazine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with donepezil.", "severity": 2}
{"drug1": "Demecarium", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Demecarium is combined with acetylcholine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with haloperidol.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with diltiazem.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "triazolam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Fluspirilene.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Ciclesonide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Difenoxin.", "severity": 2}
{"drug1": "labetalol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "methysergide", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with epinephrine.", "severity": 2}
{"drug1": "benazepril", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with BISOPROLOL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with zaleplon.", "severity": 2}
{"drug1": "lidocaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with HEROIN.", "severity": 2}
{"drug1": "thioridazine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with mepivacaine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Telmisartan.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with levodopa.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with methyldopa.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with barnidipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with thioridazine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Pipotiazine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Difenoxin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with irbesartan.", "severity": 2}
{"drug1": "ketamine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with methocarbamol.", "severity": 2}
{"drug1": "ketamine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with triprolidine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with felodipine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with methazolamide.", "severity": 2}
{"drug1": "Fondaparinux", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fondaparinux is combined with Nintedanib.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with selegiline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with pimozide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with nitrazepam.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "meperidine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Iloperidone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with meclofenamic acid.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Riociguat.", "severity": 2}
{"drug1": "haloprogin", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with nilvadipine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with MELPERONE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with zotepine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Mersalyl.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Tasimelteon.", "severity": 2}
{"drug1": "sulpiride", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with triprolidine.", "severity": 2}
{"drug1": "estazolam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "ramipril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with diclofenac.", "severity": 2}
{"drug1": "isoflurane", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with clonazepam.", "severity": 2}
{"drug1": "ramipril", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with enalapril.", "severity": 2}
{"drug1": "propofol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Clevidipine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Melatonin.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celiprolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with enalapril.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "domperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with domperidone.", "severity": 2}
{"drug1": "codeine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "codeine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "codeine", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with prochlorperazine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with leflunomide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Articaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with amcinonide.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with nadolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "quinapril", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with felodipine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "quinapril", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "quinapril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "glutethimide", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with zonisamide.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "glutethimide", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with tiagabine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with lithium ion.", "severity": 2}
{"drug1": "azelastine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with salicylic acid.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Iloperidone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with quetiapine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with clonazepam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with GUANFACINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Melatonin.", "severity": 2}
{"drug1": "etodolac", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with haloperidol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Fencamfamin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Tasimelteon.", "severity": 2}
{"drug1": "clidinium", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Empagliflozin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with acetazolamide.", "severity": 2}
{"drug1": "Butethal", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Fluspirilene.", "severity": 2}
{"drug1": "Butethal", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with flunarizine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Temsirolimus.", "severity": 2}
{"drug1": "Butethal", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with edrophonium.", "severity": 2}
{"drug1": "azelastine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with chlorthalidone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with penbutolol.", "severity": 2}
{"drug1": "halothane", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with AMILORIDE.", "severity": 2}
{"drug1": "halothane", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with doxazosin.", "severity": 2}
{"drug1": "halothane", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ethosuximide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with dantrolene.", "severity": 2}
{"drug1": "ipratropium", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with pirenzepine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with nifedipine.", "severity": 2}
{"drug1": "halothane", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with labetalol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with mefloquine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with maprotiline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Conivaptan.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Deferasirox.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Milnacipran.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Asenapine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with bupivacaine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with diltiazem.", "severity": 2}
{"drug1": "Spirapril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with nimesulide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with metaproterenol.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with tizanidine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with chlorprothixene.", "severity": 2}
{"drug1": "milrinone", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when milrinone is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "chloroquine", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with mefenamic acid.", "severity": 2}
{"drug1": "barnidipine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with clozapine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with enalapril.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with ethotoin.", "severity": 2}
{"drug1": "ramipril", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with quinapril.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Pipotiazine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Risedronic acid.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Etomidate.", "severity": 2}
{"drug1": "thiopental", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with KETAZOLAM.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Ropivacaine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with bupivacaine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with morphine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Empagliflozin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with D-mannitol.", "severity": 2}
{"drug1": "Butethal", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with Risedronic acid.", "severity": 2}
{"drug1": "benazepril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with penbutolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with diazepam.", "severity": 2}
{"drug1": "ketorolac", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with fluocinonide.", "severity": 2}
{"drug1": "temazepam", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with propofol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Pizotifen.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Methadyl acetate.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Milnacipran.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with protriptyline.", "severity": 2}
{"drug1": "timolol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with D-mannitol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Arformoterol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "midazolam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with trimipramine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with hydromorphone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "timolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Nebivolol.", "severity": 2}
{"drug1": "meperidine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Halazepam.", "severity": 2}
{"drug1": "meperidine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "meperidine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with proparacaine.", "severity": 2}
{"drug1": "meperidine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with indapamide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with benazepril.", "severity": 2}
{"drug1": "meperidine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chlormezanone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with D-mannitol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with dexamethasone.", "severity": 2}
{"drug1": "meperidine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with chlorprothixene.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Aripiprazole.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Risedronic acid.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with captopril.", "severity": 2}
{"drug1": "meperidine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Escitalopram.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with codeine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with reserpine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with trimipramine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with enflurane.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Empagliflozin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Mephobarbital.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with AMILORIDE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with ibuprofen.", "severity": 2}
{"drug1": "halcinonide", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with NICORANDIL.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with trifluoperazine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Levocetirizine.", "severity": 2}
{"drug1": "enflurane", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with triprolidine.", "severity": 2}
{"drug1": "pimozide", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Articaine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with felbamate.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "flutamide", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flutamide is combined with NITROUS ACID.", "severity": 2}
{"drug1": "amobarbital", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with loratadine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with METAXALONE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "zaleplon", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with diphenhydramine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with dyclonine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with triazolam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "quazepam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with nitrazepam.", "severity": 2}
{"drug1": "propranolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "tizanidine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with tiagabine.", "severity": 2}
{"drug1": "trazodone", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with sertraline.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Propacetamol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with scopolamine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with acemetacin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with meclizine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Nebivolol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Pizotifen.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with promethazine.", "severity": 2}
{"drug1": "prazosin", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with irbesartan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with mecamylamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Risedronic acid.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Ramelteon.", "severity": 2}
{"drug1": "amobarbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Almotriptan.", "severity": 2}
{"drug1": "meprobamate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with trimipramine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with procaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nifedipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with enalapril.", "severity": 2}
{"drug1": "benazepril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with diclofenac.", "severity": 2}
{"drug1": "tizanidine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with zonisamide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ethanol.", "severity": 2}
{"drug1": "Butethal", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Oxetacaine.", "severity": 2}
{"drug1": "clozapine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with GUANFACINE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with NAPROXEN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Prasugrel", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Prasugrel.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Tixocortol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with epirizole.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with simvastatin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Apixaban.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with sulpiride.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with nimodipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with betaxolol.", "severity": 2}
{"drug1": "bepridil", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with nitroglycerin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with trandolapril.", "severity": 2}
{"drug1": "edrophonium", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when edrophonium is combined with methacholine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with ethosuximide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with BISOPROLOL.", "severity": 2}
{"drug1": "levorphanol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with tiapride.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with captopril.", "severity": 2}
{"drug1": "butamben", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with sertraline.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with chloral hydrate.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with acebutolol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with thiopental.", "severity": 2}
{"drug1": "epirizole", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with propoxyphene.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with dyclonine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with perphenazine.", "severity": 2}
{"drug1": "epirizole", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with amcinonide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Milnacipran.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Iloperidone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with tetracaine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Tolcapone.", "severity": 2}
{"drug1": "morniflumate", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with resveratrol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "pergolide", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with methimazole.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Olsalazine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with dipyridamole.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Iloperidone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Ropivacaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with bupivacaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Etomidate.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Articaine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with mepivacaine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with scopolamine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Fospropofol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with mesoridazine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with clidinium.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with diltiazem.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when demeclocycline is combined with ADAPALENE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with fleroxacin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Pipamperone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with maprotiline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with chlorthalidone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with HEROIN.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with chloral hydrate.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Etidronic acid.", "severity": 2}
{"drug1": "olanzapine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with glutethimide.", "severity": 2}
{"drug1": "sulindac", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with loteprednol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with nimodipine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Levocetirizine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with citalopram.", "severity": 2}
{"drug1": "morphine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with thiamylal.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Risedronic acid.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with meclizine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with nimesulide.", "severity": 2}
{"drug1": "scopolamine", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with oxyphenonium.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with triamcinolone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with clonidine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with scopolamine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with hydromorphone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "isradipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Salsalate.", "severity": 2}
{"drug1": "paramethasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with triamcinolone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with tizanidine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with alclofenac.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with scopolamine.", "severity": 2}
{"drug1": "furosemide", "drug2": "amikacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with amikacin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with primidone.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with pirenzepine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with cinnarizine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "risperidone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with clidinium.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Lurasidone.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with propoxyphene.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Difenoxin.", "severity": 2}
{"drug1": "thalidomide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with methazolamide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Eplerenone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with oxaprozin.", "severity": 2}
{"drug1": "meperidine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with buspirone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with CLONIXIN.", "severity": 2}
{"drug1": "propofol", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Sacubitril.", "severity": 2}
{"drug1": "methyldopa", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with acebutolol.", "severity": 2}
{"drug1": "diflunisal", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with methylprednisolone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Lenvatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Lenvatinib.", "severity": 2}
{"drug1": "methyldopa", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with captopril.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with propranolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ifosfamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ifosfamide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with clonidine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with meperidine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with loratadine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with isocarboxazid.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Normethadone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with brimonidine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Difenoxin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ethosuximide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with norfloxacin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with AMILORIDE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with thiopental.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Echothiophate.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with periciazine.", "severity": 2}
{"drug1": "ethotoin", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with Desloratadine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with NAPROXEN.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with nadolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Ciclesonide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with Cariprazine.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with oxycodone.", "severity": 2}
{"drug1": "mafenide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mafenide is combined with mecamylamine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with digitoxin.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with fluvastatin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with propranolol.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with clonidine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Mirabegron.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with triamcinolone.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Levocetirizine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with amisulpride.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with Torasemide.", "severity": 2}
{"drug1": "tropicamide", "drug2": "biperiden", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with biperiden.", "severity": 2}
{"drug1": "lorazepam", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with alprazolam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Levocetirizine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with formestane.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with rasagiline.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Lumiracoxib.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with fenoprofen.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with selegiline.", "severity": 2}
{"drug1": "nefazodone", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with trifluoperazine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with isoxsuprine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with chloroquine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with rosiglitazone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with SERATRODAST.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with sulindac.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Fluspirilene.", "severity": 2}
{"drug1": "perphenazine", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with olanzapine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Tolcapone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with amitriptyline.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Pipotiazine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with hydrocortisone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Nabilone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "testolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with testolactone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Lercanidipine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with fluoxetine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with DESFLURANE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Aripiprazole.", "severity": 2}
{"drug1": "lorazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with clotiazepam.", "severity": 2}
{"drug1": "levodopa", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "zonisamide", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with flunarizine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with hydromorphone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with estrone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with sevoflurane.", "severity": 2}
{"drug1": "antipyrine", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with flumethasone.", "severity": 2}
{"drug1": "selegiline", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Articaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with butalbital.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Pizotifen.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nimodipine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with zotepine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with paroxetine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with MELPERONE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Ramelteon.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Oxetacaine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Tolcapone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with apraclonidine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Ticagrelor.", "severity": 2}
{"drug1": "enflurane", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Triflusal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Triflusal.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nilvadipine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with efavirenz.", "severity": 2}
{"drug1": "enflurane", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with glutethimide.", "severity": 2}
{"drug1": "Nelarabine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nelarabine is combined with leflunomide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with tiapride.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with nitroglycerin.", "severity": 2}
{"drug1": "morphine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with carvedilol.", "severity": 2}
{"drug1": "Articaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with primidone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with Canagliflozin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with zotepine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tofacitinib is combined with clozapine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with promethazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with clonazepam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with sparfloxacin.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with nadolol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Fludarabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Fludarabine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Melatonin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with atorvastatin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with quetiapine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "tiapride", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Olopatadine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with cinoxacin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with fludiazepam.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Ramelteon.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Aripiprazole.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with chlorprothixene.", "severity": 2}
{"drug1": "pergolide", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Levalbuterol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with flunarizine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Asenapine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with sevoflurane.", "severity": 2}
{"drug1": "isradipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with captopril.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with desipramine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with Riociguat.", "severity": 2}
{"drug1": "amifostine", "drug2": "apomorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with apomorphine.", "severity": 2}
{"drug1": "minocycline", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minocycline is combined with tretinoin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with dibucaine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with norfloxacin.", "severity": 2}
{"drug1": "budesonide", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with Demecarium.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Echothiophate.", "severity": 2}
{"drug1": "triazolam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with DESFLURANE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with mycophenolic acid.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with nabumetone.", "severity": 2}
{"drug1": "methysergide", "drug2": "Posaconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Posaconazole.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with suprofen.", "severity": 2}
{"drug1": "benztropine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with codeine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Canrenoic acid.", "severity": 2}
{"drug1": "HEROIN", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with brotizolam.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with ethotoin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Ketobemidone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with tretinoin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Conivaptan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Bretylium.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Eprosartan.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with risperidone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with hydralazine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Canagliflozin is combined with Riociguat.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Pinaverium.", "severity": 2}
{"drug1": "butamben", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with clidinium.", "severity": 2}
{"drug1": "imipramine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with felbamate.", "severity": 2}
{"drug1": "paroxetine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with trimipramine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Pizotifen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Tasimelteon.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with methylprednisolone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Etidocaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Flibanserin.", "severity": 2}
{"drug1": "propantheline", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with hydromorphone.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Retigabine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Loxoprofen.", "severity": 2}
{"drug1": "promazine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Tasimelteon.", "severity": 2}
{"drug1": "promazine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Ramelteon.", "severity": 2}
{"drug1": "atenolol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with losartan.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with fludrocortisone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Canagliflozin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with chlorprothixene.", "severity": 2}
{"drug1": "polythiazide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "cetirizine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Droxicam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Loxoprofen.", "severity": 2}
{"drug1": "morphine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with promethazine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with clonazepam.", "severity": 2}
{"drug1": "thalidomide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with hydralazine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with CLONIXIN.", "severity": 2}
{"drug1": "ketamine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with zotepine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with potassium ion.", "severity": 2}
{"drug1": "amifostine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with thalidomide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with carprofen.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with benzphetamine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with isradipine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with betaxolol.", "severity": 2}
{"drug1": "tiapride", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with doxepin.", "severity": 2}
{"drug1": "Dimethyl fumarate", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with leflunomide.", "severity": 2}
{"drug1": "triprolidine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Ramelteon.", "severity": 2}
{"drug1": "Nabilone", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with NITROUS ACID.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with cilazapril.", "severity": 2}
{"drug1": "citalopram", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with MOLINDONE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with dexamethasone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Articaine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with dantrolene.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Propacetamol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Asenapine.", "severity": 2}
{"drug1": "Melatonin", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with nortriptyline.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Remoxipride.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with amoxapine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with tetracaine.", "severity": 2}
{"drug1": "clonidine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with tizanidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with furosemide.", "severity": 2}
{"drug1": "clonidine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with ZILEUTON.", "severity": 2}
{"drug1": "Butethal", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with trimipramine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with etodolac.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Lumiracoxib.", "severity": 2}
{"drug1": "imipramine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with methyclothiazide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with zonisamide.", "severity": 2}
{"drug1": "paroxetine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with METAXALONE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with Gatifloxacin.", "severity": 2}
{"drug1": "citalopram", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Aceprometazine.", "severity": 2}
{"drug1": "enflurane", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with procaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with tiagabine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with cocaine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ondansetron.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Pomalidomide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with acemetacin.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with dichlorphenamide.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Hexobarbital.", "severity": 2}
{"drug1": "dyclonine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with zotepine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with MELPERONE.", "severity": 2}
{"drug1": "Etomidate", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with fexofenadine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with VERAPAMIL.", "severity": 2}
{"drug1": "glutethimide", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with butamben.", "severity": 2}
{"drug1": "pargyline", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with bupropion.", "severity": 2}
{"drug1": "oxycodone", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with nortriptyline.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with buprenorphine.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "SODIUM BICARBONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with fluocinonide.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Ciclesonide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with nefazodone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Clevidipine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Aceclofenac.", "severity": 2}
{"drug1": "enalapril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with zaltoprofen.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with efavirenz.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with nalidixic acid.", "severity": 2}
{"drug1": "lorazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with scopolamine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with methazolamide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Eplerenone.", "severity": 2}
{"drug1": "aspirin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Risedronic acid.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with quinapril.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with malathion.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "promazine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nitric oxide.", "severity": 2}
{"drug1": "Nabilone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Pazopanib.", "severity": 2}
{"drug1": "medrysone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Olmesartan.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with mesoridazine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with desoximetasone.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with methscopolamine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Pefloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with estrone.", "severity": 2}
{"drug1": "Amrinone", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "isoflurane", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with labetalol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with thiopental.", "severity": 2}
{"drug1": "propranolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with AMILORIDE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Metipranolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with ethosuximide.", "severity": 2}
{"drug1": "isoflurane", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with doxazosin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with rivastigmine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with zotepine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with MELPERONE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Difenoxin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESONIDE is combined with physostigmine.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with indapamide.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with etodolac.", "severity": 2}
{"drug1": "methysergide", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with oxybutynin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with nadolol.", "severity": 2}
{"drug1": "risperidone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with prilocaine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with bumetanide.", "severity": 2}
{"drug1": "sulindac", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Estrone sulfate.", "severity": 2}
{"drug1": "tizanidine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with chlorothiazide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Iloperidone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with nadolol.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "midazolam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with sulpiride.", "severity": 2}
{"drug1": "leflunomide", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Pazopanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Pazopanib.", "severity": 2}
{"drug1": "fosinopril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with carvedilol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with GUANFACINE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with leflunomide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with halothane.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with MELPERONE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with thiopental.", "severity": 2}
{"drug1": "prilocaine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with ethosuximide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with hydralazine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Perospirone.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Clevidipine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with tubocurarine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with etodolac.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with tizanidine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with furosemide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with zotepine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Levomepromazine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with naratriptan.", "severity": 2}
{"drug1": "protriptyline", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with rizatriptan.", "severity": 2}
{"drug1": "protriptyline", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with fexofenadine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Normethadone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "promazine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "ketamine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with carisoprodol.", "severity": 2}
{"drug1": "triazolam", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Lurasidone.", "severity": 2}
{"drug1": "naratriptan", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with sulpiride.", "severity": 2}
{"drug1": "ketamine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with sulpiride.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Thioproperazine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Pipotiazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with methadone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with rasagiline.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Clobetasone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Cis-mdp.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "bromazepam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with glutethimide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with mycophenolic acid.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with doxepin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "codeine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Flibanserin.", "severity": 2}
{"drug1": "butalbital", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with imipramine.", "severity": 2}
{"drug1": "zotepine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with budesonide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with GUANFACINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Pizotifen.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with D-mannitol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with cocaine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with halothane.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Iloperidone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with nadolol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Levetiracetam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Olopatadine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with penbutolol.", "severity": 2}
{"drug1": "temazepam", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "temazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "triazolam", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with glutethimide.", "severity": 2}
{"drug1": "cocaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with chlorprothixene.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Aripiprazole.", "severity": 2}
{"drug1": "triazolam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with chlorthalidone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with alclometasone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with metoclopramide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with tiagabine.", "severity": 2}
{"drug1": "estriol", "drug2": "Ospemifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estriol is combined with Ospemifene.", "severity": 2}
{"drug1": "mafenide", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mafenide is combined with NITROUS ACID.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with flunisolide.", "severity": 2}
{"drug1": "oxycodone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with tiapride.", "severity": 2}
{"drug1": "meperidine", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with cyclothiazide.", "severity": 2}
{"drug1": "benzocaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with zonisamide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with flunisolide.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with ouabain.", "severity": 2}
{"drug1": "azelastine", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with venlafaxine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with fexofenadine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Nilotinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Nilotinib.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Pizotifen.", "severity": 2}
{"drug1": "benzocaine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with tiagabine.", "severity": 2}
{"drug1": "codeine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "codeine", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with pargyline.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with tolfenamic acid.", "severity": 2}
{"drug1": "codeine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with vigabatrin.", "severity": 2}
{"drug1": "codeine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with thiothixene.", "severity": 2}
{"drug1": "flurazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with dyclonine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Frovatriptan.", "severity": 2}
{"drug1": "sulindac", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "meclizine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with maprotiline.", "severity": 2}
{"drug1": "meperidine", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with linezolid.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with baclofen.", "severity": 2}
{"drug1": "doxylamine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with venlafaxine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with methyclothiazide.", "severity": 2}
{"drug1": "morphine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Pramocaine.", "severity": 2}
{"drug1": "morphine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Propoxycaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with isoxsuprine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with NAPROXEN.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with atenolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Difenoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "methazolamide", "drug2": "metformin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with metformin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Naftifine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with methyldopa.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "etizolam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with fluoxetine.", "severity": 2}
{"drug1": "etizolam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with duloxetine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with ethotoin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "cabergoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with cabergoline.", "severity": 2}
{"drug1": "butabarbital", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with haloperidol.", "severity": 2}
{"drug1": "triprolidine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with fluoxetine.", "severity": 2}
{"drug1": "terconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Amrinone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with halcinonide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with difluprednate.", "severity": 2}
{"drug1": "butalbital", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Olopatadine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with salicylamide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Escitalopram.", "severity": 2}
{"drug1": "Etomidate", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with baclofen.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with scopolamine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Normethadone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with topiramate.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with oxprenolol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with isradipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with bumetanide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with KETAZOLAM.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Olmesartan.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with fludrocortisone.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with prazepam.", "severity": 2}
{"drug1": "ipratropium", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with morphine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Torasemide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Torasemide.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Clevidipine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Echothiophate.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with norfloxacin.", "severity": 2}
{"drug1": "bumetanide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with deslanoside.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with benzocaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with dibucaine.", "severity": 2}
{"drug1": "triamterene", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with nifedipine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with tiapride.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with butamben.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "medrysone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with fluvastatin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with D-mannitol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with metolazone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with tiagabine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with cocaine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with floctafenine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with butorphanol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with clonazepam.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with promethazine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with topiramate.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with protriptyline.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with amitriptyline.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Iloperidone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with difluprednate.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with oxymorphone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with cetirizine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with METAXALONE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "flurazepam", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with zopiclone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with difluprednate.", "severity": 2}
{"drug1": "glutethimide", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with desipramine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with rasagiline.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Pinaverium.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vinorelbine is combined with leflunomide.", "severity": 2}
{"drug1": "ramipril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Salsalate.", "severity": 2}
{"drug1": "nicergoline", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with midazolam.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Ethylmorphine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with pentazocine.", "severity": 2}
{"drug1": "halothane", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with fludiazepam.", "severity": 2}
{"drug1": "buspirone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Lurasidone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with trimipramine.", "severity": 2}
{"drug1": "butenafine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Lacidipine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Propiverine.", "severity": 2}
{"drug1": "butenafine", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with cilnidipine.", "severity": 2}
{"drug1": "butenafine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Azelnidipine.", "severity": 2}
{"drug1": "butenafine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Benidipine.", "severity": 2}
{"drug1": "halothane", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Lacidipine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with methylprednisolone.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with fluoxetine.", "severity": 2}
{"drug1": "meclizine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Milnacipran.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with polythiazide.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with oxycodone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with dobutamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with maprotiline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Enalaprilat.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Oxetacaine.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with Apixaban.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with nimodipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Clevidipine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Ropivacaine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with bupivacaine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Zoledronic acid.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Etomidate.", "severity": 2}
{"drug1": "triazolam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with triprolidine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "ATROPINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with ATROPINE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with procarbazine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Mephobarbital.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with sevoflurane.", "severity": 2}
{"drug1": "valsartan", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with carprofen.", "severity": 2}
{"drug1": "buspirone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Aceprometazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with desipramine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with flunisolide.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "dyclonine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Difenoxin.", "severity": 2}
{"drug1": "reserpine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with D-mannitol.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with clomipramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with MOLINDONE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with clomipramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with scopolamine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Clodronic Acid.", "severity": 2}
{"drug1": "thiothixene", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Canrenoic acid.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with D-mannitol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with glutethimide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with tubocurarine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with scopolamine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "phenazopyridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with phenazopyridine.", "severity": 2}
{"drug1": "meperidine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "brotizolam", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with primidone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Pipamperone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with Riociguat.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with METAXALONE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with quetiapine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with ketamine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Oxetacaine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "eperisone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when eperisone is combined with atorvastatin.", "severity": 2}
{"drug1": "epinastine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with salicylic acid.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "bepridil", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Pitavastatin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with flunarizine.", "severity": 2}
{"drug1": "enflurane", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with nefazodone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Fluspirilene.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with methocarbamol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with sevoflurane.", "severity": 2}
{"drug1": "morphine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with triprolidine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with fexofenadine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with nitroglycerin.", "severity": 2}
{"drug1": "halothane", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with triamterene.", "severity": 2}
{"drug1": "enflurane", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Tolcapone.", "severity": 2}
{"drug1": "enflurane", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with amitriptyline.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with zotepine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with methoxyflurane.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "halothane", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Potassium citrate.", "severity": 2}
{"drug1": "butorphanol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with maprotiline.", "severity": 2}
{"drug1": "tolterodine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with hydromorphone.", "severity": 2}
{"drug1": "estazolam", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "thioridazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "diazepam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Butethal.", "severity": 2}
{"drug1": "temazepam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with gabapentin.", "severity": 2}
{"drug1": "diazepam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with amobarbital.", "severity": 2}
{"drug1": "propofol", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with NITROUS ACID.", "severity": 2}
{"drug1": "loratadine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Pipotiazine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with rivastigmine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Retigabine.", "severity": 2}
{"drug1": "risperidone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with bromazepam.", "severity": 2}
{"drug1": "furosemide", "drug2": "plicamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with plicamycin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with betaxolol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Fluspirilene.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Tasimelteon.", "severity": 2}
{"drug1": "clorazepate", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with brotizolam.", "severity": 2}
{"drug1": "benazepril", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with dichlorphenamide.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with scopolamine.", "severity": 2}
{"drug1": "codeine", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "ketorolac", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "enflurane", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Normethadone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Phenelzine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Temsirolimus.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with dipyridamole.", "severity": 2}
{"drug1": "suprofen", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Etoricoxib.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with NICORANDIL.", "severity": 2}
{"drug1": "nicergoline", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with metronidazole.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Repaglinide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with CYCLIZINE.", "severity": 2}
{"drug1": "clidinium", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Tasimelteon.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Lormetazepam.", "severity": 2}
{"drug1": "enflurane", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with thioridazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with oxybutynin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with chlorpheniramine.", "severity": 2}
{"drug1": "memantine", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when memantine is combined with Varenicline.", "severity": 2}
{"drug1": "methysergide", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with desipramine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "zidovudine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with zidovudine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with leflunomide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with tolmetin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with flunarizine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with clomipramine.", "severity": 2}
{"drug1": "baclofen", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Tolcapone.", "severity": 2}
{"drug1": "baclofen", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with amitriptyline.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Pipotiazine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with GUANFACINE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with estazolam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with enflurane.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with brotizolam.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with BISOPROLOL.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Lornoxicam.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with VERAPAMIL.", "severity": 2}
{"drug1": "morphine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with propranolol.", "severity": 2}
{"drug1": "benazepril", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with mecamylamine.", "severity": 2}
{"drug1": "morphine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with clonidine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "PARALDEHYDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with PARALDEHYDE.", "severity": 2}
{"drug1": "temazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with sulpiride.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "linezolid", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with prochlorperazine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with alclometasone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with midazolam.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with niflumic acid.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "celecoxib", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with nimesulide.", "severity": 2}
{"drug1": "temazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "primidone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with maprotiline.", "severity": 2}
{"drug1": "dyclonine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with ethotoin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with labetalol.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with tetracaine.", "severity": 2}
{"drug1": "methadone", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Efonidipine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with cetirizine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with doxazosin.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Fluspirilene.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMPHETAMINE is combined with labetalol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Ropivacaine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with morphine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Nebivolol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Tapentadol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Torasemide.", "severity": 2}
{"drug1": "reserpine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "thiothixene", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with butalbital.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "mesalamine", "drug2": "dorzolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with dorzolamide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with cetirizine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Drospirenone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with protriptyline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ibrutinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Ibrutinib.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with ketamine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Ramelteon.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with quinidine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with quetiapine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with flunisolide.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "quazepam", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with proparacaine.", "severity": 2}
{"drug1": "etodolac", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with formestane.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with rasagiline.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with rivastigmine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "docetaxel", "drug2": "nilutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with nilutamide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Sorafenib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Eplerenone.", "severity": 2}
{"drug1": "bromazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with chlormezanone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "reserpine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chlormezanone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with cinnarizine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with quazepam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with zopiclone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "pargyline", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with bezafibrate.", "severity": 2}
{"drug1": "tetracaine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with tizanidine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with cocaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with tiagabine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with chloroquine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with ondansetron.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Propoxycaine.", "severity": 2}
{"drug1": "reserpine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with chlorprothixene.", "severity": 2}
{"drug1": "reserpine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with chlorothiazide.", "severity": 2}
{"drug1": "reserpine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with bumetanide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Canagliflozin is combined with isoxsuprine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with zonisamide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with sulindac.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with proparacaine.", "severity": 2}
{"drug1": "primidone", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with paroxetine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Halazepam.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Methadyl acetate.", "severity": 2}
{"drug1": "meclizine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "tizanidine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with terazosin.", "severity": 2}
{"drug1": "promazine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Pramocaine.", "severity": 2}
{"drug1": "imipramine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with SERTINDOLE.", "severity": 2}
{"drug1": "promazine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Propoxycaine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with lidocaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Perospirone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Clodronic Acid.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with flunarizine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with selegiline.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Etidocaine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Ciclesonide.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Paricalcitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM CHLORIDE is combined with Paricalcitol.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with decamethonium.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with amcinonide.", "severity": 2}
{"drug1": "thiothixene", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with maprotiline.", "severity": 2}
{"drug1": "thiothixene", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with mesoridazine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with isradipine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with loteprednol.", "severity": 2}
{"drug1": "carprofen", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Etidronic acid.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Olmesartan.", "severity": 2}
{"drug1": "temazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Raltitrexed", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Raltitrexed is combined with clozapine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with papaverine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with felodipine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with prilocaine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with ethotoin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Difenoxin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with carvedilol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Thioproperazine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with thiothixene.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Frovatriptan.", "severity": 2}
{"drug1": "sulpiride", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with oxprenolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Fospropofol.", "severity": 2}
{"drug1": "reserpine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with enflurane.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Escitalopram.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with difluprednate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with prazepam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with halcinonide.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with loteprednol.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with Clevidipine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with pentazocine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Phenelzine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with epirizole.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with levorphanol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with pentazocine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with papaverine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with HEROIN.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MEPHENTERMINE is combined with nylidrin.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with oxymorphone.", "severity": 2}
{"drug1": "promazine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with propoxyphene.", "severity": 2}
{"drug1": "promazine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with dyclonine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with tiapride.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with acetylcholine.", "severity": 2}
{"drug1": "methysergide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with fluoxetine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with clidinium.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with enalapril.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with Levetiracetam.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with protriptyline.", "severity": 2}
{"drug1": "sertraline", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Perospirone.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with cetirizine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with prednisone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with nortriptyline.", "severity": 2}
{"drug1": "levorphanol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with amoxapine.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "trazodone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "aspirin", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with rosiglitazone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Lurasidone.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with clomipramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Sacubitril.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Lornoxicam.", "severity": 2}
{"drug1": "Melatonin", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with topiramate.", "severity": 2}
{"drug1": "enalapril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with oxaprozin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with SUFENTANIL.", "severity": 2}
{"drug1": "promazine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with carisoprodol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with chlorthalidone.", "severity": 2}
{"drug1": "enalapril", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "butalbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with tizanidine.", "severity": 2}
{"drug1": "atenolol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with bumetanide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with topiramate.", "severity": 2}
{"drug1": "atenolol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with quinapril.", "severity": 2}
{"drug1": "atenolol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with fenoprofen.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "loratadine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with METAXALONE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Olsalazine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with captopril.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with Escitalopram.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with MOXONIDINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with glutethimide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "omeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with omeprazole.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Empagliflozin.", "severity": 2}
{"drug1": "midodrine", "drug2": "norepinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with norepinephrine.", "severity": 2}
{"drug1": "clemastine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Levetiracetam.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with Clevidipine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "olanzapine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with propoxyphene.", "severity": 2}
{"drug1": "enalapril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with fenbufen.", "severity": 2}
{"drug1": "olanzapine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with dyclonine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with flunisolide.", "severity": 2}
{"drug1": "acebutolol", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with quetiapine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with rivastigmine.", "severity": 2}
{"drug1": "tirofiban", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with physostigmine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Desloratadine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with mepivacaine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cytarabine is combined with clozapine.", "severity": 2}
{"drug1": "meperidine", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "methadone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Pomalidomide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with tizanidine.", "severity": 2}
{"drug1": "ethanol", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with trazodone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with meperidine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with Pefloxacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with sulfasalazine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with ethosuximide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "Articaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with loratadine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with sulpiride.", "severity": 2}
{"drug1": "nicardipine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with cilazapril.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with MELPERONE.", "severity": 2}
{"drug1": "naratriptan", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with tetracaine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolpidem is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with irbesartan.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Etoricoxib.", "severity": 2}
{"drug1": "losartan", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with prilocaine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with Olsalazine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with clonidine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with pimozide.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cariprazine is combined with methylphenidate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Cis-mdp.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with thiopental.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Apremilast.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "bezafibrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with bezafibrate.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with efavirenz.", "severity": 2}
{"drug1": "ethotoin", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with sertraline.", "severity": 2}
{"drug1": "Spirapril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with mefenamic acid.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Pipamperone.", "severity": 2}
{"drug1": "butalbital", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with nefazodone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with triamterene.", "severity": 2}
{"drug1": "meperidine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with tetracaine.", "severity": 2}
{"drug1": "amifostine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with tizanidine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with pramipexole.", "severity": 2}
{"drug1": "amifostine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with furosemide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with MOLINDONE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "rabeprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with rabeprazole.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "bicalutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with bicalutamide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Pramocaine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with D-mannitol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Fencamfamin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Propoxycaine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with tetracaine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with chlormezanone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Milnacipran.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with methocarbamol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "benztropine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with morphine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Aliskiren.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with epirizole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Escitalopram.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "triamterene", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with benazepril.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with dipyridamole.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Tixocortol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Perospirone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Levocetirizine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with estazolam.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with triamterene.", "severity": 2}
{"drug1": "risperidone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with zonisamide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Clevidipine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with hydrocortisone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with leflunomide.", "severity": 2}
{"drug1": "codeine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with indapamide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with modafinil.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with tiapride.", "severity": 2}
{"drug1": "codeine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "codeine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Halazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with proparacaine.", "severity": 2}
{"drug1": "risperidone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with proparacaine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Sodium aurothiomalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Sodium aurothiomalate.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with terazosin.", "severity": 2}
{"drug1": "valsartan", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "bepridil", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with isoflurane.", "severity": 2}
{"drug1": "Butethal", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with lithium ion.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with alclofenac.", "severity": 2}
{"drug1": "bepridil", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with tretinoin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Aliskiren.", "severity": 2}
{"drug1": "ropinirole", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with trandolapril.", "severity": 2}
{"drug1": "HEROIN", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with metolazone.", "severity": 2}
{"drug1": "promazine", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with zopiclone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with nefazodone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with procarbazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with aspirin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with flunarizine.", "severity": 2}
{"drug1": "clemastine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Desloratadine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with pyridostigmine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with epirizole.", "severity": 2}
{"drug1": "procaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Milnacipran.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with maprotiline.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Normethadone.", "severity": 2}
{"drug1": "procaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with clonidine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Lercanidipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "amprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with amprenavir.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with epoprostenol.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with amcinonide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Tapentadol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Vilazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Vilazodone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when actinomycin D is combined with clozapine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with trifluoperazine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Efonidipine.", "severity": 2}
{"drug1": "prednisone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with leflunomide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with thioridazine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with rasagiline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with alclofenac.", "severity": 2}
{"drug1": "amoxapine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with vigabatrin.", "severity": 2}
{"drug1": "tioconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with ethosuximide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with azelastine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with triflupromazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with butamben.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with flunitrazepam.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "meperidine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Desloratadine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Tolcapone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with nimesulide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with promethazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with clonazepam.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with bromocriptine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Desloratadine.", "severity": 2}
{"drug1": "loxapine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with mepivacaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with zaleplon.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with edrophonium.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Estrone sulfate.", "severity": 2}
{"drug1": "docetaxel", "drug2": "vindesine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with vindesine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with aspirin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with GUANFACINE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "mitomycin C", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with mitomycin C.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with enalapril.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Bexarotene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Bexarotene.", "severity": 2}
{"drug1": "donepezil", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when donepezil is combined with Carbamylcholine.", "severity": 2}
{"drug1": "meclizine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with paroxetine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with quetiapine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with fenbufen.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with CYCLIZINE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Escitalopram.", "severity": 2}
{"drug1": "valsartan", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Etomidate", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with lithium ion.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with nortriptyline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with benazepril.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Cis-mdp.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Hexobarbital.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with levorphanol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with METAXALONE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Levomilnacipran.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with clomipramine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Pipotiazine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with doxepin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "pimozide", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Hexobarbital.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with indapamide.", "severity": 2}
{"drug1": "pimozide", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Butethal.", "severity": 2}
{"drug1": "estrone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with norfloxacin.", "severity": 2}
{"drug1": "pimozide", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with amobarbital.", "severity": 2}
{"drug1": "reserpine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ethosuximide.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with meperidine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Clevidipine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with thiamylal.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Agomelatine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with halothane.", "severity": 2}
{"drug1": "diclofenac", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Halobetasol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with amitriptyline.", "severity": 2}
{"drug1": "zaleplon", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with dyclonine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Tolcapone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with propoxyphene.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Nitroprusside.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with papaverine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with flunarizine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Fluspirilene.", "severity": 2}
{"drug1": "losartan", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with meclofenamic acid.", "severity": 2}
{"drug1": "prilocaine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Benidipine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Azelnidipine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Lacidipine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Efonidipine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Levetiracetam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with METAXALONE.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with diltiazem.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Articaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with citalopram.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with oxprenolol.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Aripiprazole.", "severity": 2}
{"drug1": "trimipramine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with scopolamine.", "severity": 2}
{"drug1": "temazepam", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Pitavastatin.", "severity": 2}
{"drug1": "prazepam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Tramadol", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with carisoprodol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Indacaterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Indacaterol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "etodolac", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with carprofen.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with fluoxetine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Lacidipine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with duloxetine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with nadolol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Ramelteon.", "severity": 2}
{"drug1": "meperidine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with fludiazepam.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Trospium.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Lormetazepam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with baclofen.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with OLODATEROL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Normethadone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "doxepin", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "valsartan", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with isradipine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Olmesartan.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Ciclesonide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with clonazepam.", "severity": 2}
{"drug1": "secobarbital", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with levorphanol.", "severity": 2}
{"drug1": "midodrine", "drug2": "metaraminol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with metaraminol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with topiramate.", "severity": 2}
{"drug1": "ondansetron", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with benzyl alcohol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with oxycodone.", "severity": 2}
{"drug1": "sulindac", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with alclometasone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with fluvoxamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with carisoprodol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Apixaban.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Teriflunomide.", "severity": 2}
{"drug1": "etizolam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Flibanserin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with maprotiline.", "severity": 2}
{"drug1": "captopril", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with azelastine.", "severity": 2}
{"drug1": "risperidone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with topiramate.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with betamethasone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Etomidate.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with bupivacaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Ropivacaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with alclometasone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Cladribine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Cladribine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with imipramine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with loratadine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Agomelatine.", "severity": 2}
{"drug1": "pergolide", "drug2": "tioconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with tioconazole.", "severity": 2}
{"drug1": "pergolide", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Salbutamol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with clemastine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with lidocaine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with hydralazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with butalbital.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Lornoxicam.", "severity": 2}
{"drug1": "amisulpride", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with imipramine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with mycophenolic acid.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Tasimelteon.", "severity": 2}
{"drug1": "ketamine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "dyclonine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with clonidine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Apremilast", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with dexamethasone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with acebutolol.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with captopril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with tizanidine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with clonazepam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with bumetanide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Oxetacaine.", "severity": 2}
{"drug1": "propantheline", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with buprenorphine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with flurandrenolide.", "severity": 2}
{"drug1": "miconazole", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with nitrendipine.", "severity": 2}
{"drug1": "miconazole", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with nilvadipine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with triamterene.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with quetiapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with propranolol.", "severity": 2}
{"drug1": "citalopram", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Pipotiazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with clonidine.", "severity": 2}
{"drug1": "clozapine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with carisoprodol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with meclofenamic acid.", "severity": 2}
{"drug1": "clozapine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nimodipine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Tolvaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Tolvaptan.", "severity": 2}
{"drug1": "risperidone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Retigabine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with GUANFACINE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Pipamperone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nortriptyline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with benazepril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with amoxapine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Retigabine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Levalbuterol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with dipyridamole.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with etizolam.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Levomepromazine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Iloperidone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Tolcapone.", "severity": 2}
{"drug1": "sulpiride", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with amitriptyline.", "severity": 2}
{"drug1": "estazolam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Paliperidone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with nimesulide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with carisoprodol.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with sulpiride.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Pipotiazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with topiramate.", "severity": 2}
{"drug1": "phentolamine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with apraclonidine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Olmesartan.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with vigabatrin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Apremilast.", "severity": 2}
{"drug1": "procaine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with mepivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with benzocaine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with sumatriptan.", "severity": 2}
{"drug1": "methadone", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with potassium ion.", "severity": 2}
{"drug1": "midazolam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Tolcapone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Olsalazine.", "severity": 2}
{"drug1": "midazolam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with amitriptyline.", "severity": 2}
{"drug1": "selegiline", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with quetiapine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with prochlorperazine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with brotizolam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with isoproterenol.", "severity": 2}
{"drug1": "halcinonide", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with decamethonium.", "severity": 2}
{"drug1": "morphine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with trimipramine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with bupivacaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "sildenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with sildenafil.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Desloratadine.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with Lercanidipine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with reserpine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Normethadone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with loratadine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Pomalidomide.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with imipramine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Salsalate", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Pizotifen.", "severity": 2}
{"drug1": "loratadine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with periciazine.", "severity": 2}
{"drug1": "propofol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ethotoin.", "severity": 2}
{"drug1": "propofol", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with tretinoin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with flumethasone.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Bendamustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when allopurinol is combined with Bendamustine.", "severity": 2}
{"drug1": "propofol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with prilocaine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "felbamate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with Pomalidomide.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with papaverine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nifedipine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with fludrocortisone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with BISOPROLOL.", "severity": 2}
{"drug1": "butenafine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Amrinone.", "severity": 2}
{"drug1": "cerulenin", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with nimodipine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaliplatin is combined with topotecan.", "severity": 2}
{"drug1": "alclofenac", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with sulpiride.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with hydrocortisone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with amitriptyline.", "severity": 2}
{"drug1": "indomethacin", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with oxaprozin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with lidocaine.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Iloperidone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with NITROUS ACID.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with pentazocine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Flibanserin.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with Icatibant.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with Gatifloxacin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Pomalidomide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with memantine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Ropivacaine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with terazosin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Fluprednidene.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Etidocaine.", "severity": 2}
{"drug1": "propranolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with nicotine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Cis-mdp.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with zaltoprofen.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Tolcapone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with ondansetron.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with tiagabine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with cocaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with zonisamide.", "severity": 2}
{"drug1": "ketamine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with proparacaine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Icatibant.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with METAXALONE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with papaverine.", "severity": 2}
{"drug1": "morphine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with nifedipine.", "severity": 2}
{"drug1": "methadone", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Almotriptan.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with hydralazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with ethosuximide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentoxifylline is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "amobarbital", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with thiopental.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with trandolapril.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with brotizolam.", "severity": 2}
{"drug1": "pentazocine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with oxazepam.", "severity": 2}
{"drug1": "mesalamine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with amcinonide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "cyclosporin A", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Temsirolimus is combined with cyclosporin A.", "severity": 2}
{"drug1": "desipramine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Eprosartan.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with trazodone.", "severity": 2}
{"drug1": "suprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with halcinonide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with prazepam.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with procarbazine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with salicylamide.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with clonidine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with ethotoin.", "severity": 2}
{"drug1": "diazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with doxepin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with oxprenolol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Agomelatine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with sotalol.", "severity": 2}
{"drug1": "tiagabine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with clomipramine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "paroxetine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with naratriptan.", "severity": 2}
{"drug1": "paroxetine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with rizatriptan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Aliskiren.", "severity": 2}
{"drug1": "loratadine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with nimodipine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with amcinonide.", "severity": 2}
{"drug1": "loxapine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with triflupromazine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Desloratadine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with periciazine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "meperidine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with chlorthalidone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with equilin.", "severity": 2}
{"drug1": "meperidine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Atracurium besylate.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with BISOPROLOL.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with nimodipine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with norfloxacin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with tiapride.", "severity": 2}
{"drug1": "haloperidol", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with MELPERONE.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with midazolam.", "severity": 2}
{"drug1": "nefazodone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with zotepine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Agomelatine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonazepam is combined with desipramine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaproterenol is combined with dopamine.", "severity": 2}
{"drug1": "prazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with clidinium.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with cilazapril.", "severity": 2}
{"drug1": "codeine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Oxetacaine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Olopatadine.", "severity": 2}
{"drug1": "triazolam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with amobarbital.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Desloratadine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Arformoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Arformoterol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with mepivacaine.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Fondaparinux", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Fondaparinux.", "severity": 2}
{"drug1": "morphine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "morphine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with flunitrazepam.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with isoproterenol.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Torasemide", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with prazosin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Escitalopram.", "severity": 2}
{"drug1": "paroxetine", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with mirtazapine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Teriflunomide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with dexamethasone.", "severity": 2}
{"drug1": "midodrine", "drug2": "phenmetrazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with phenmetrazine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with papaverine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with nifedipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with antipyrine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with lidocaine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with clemastine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with venlafaxine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with benzocaine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Lacidipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Efonidipine.", "severity": 2}
{"drug1": "temazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with vigabatrin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with meclizine.", "severity": 2}
{"drug1": "atenolol", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with nisoldipine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with benzyl alcohol.", "severity": 2}
{"drug1": "loxapine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with zotepine.", "severity": 2}
{"drug1": "halothane", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with acebutolol.", "severity": 2}
{"drug1": "levodopa", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with prilocaine.", "severity": 2}
{"drug1": "levodopa", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with flunarizine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Ropivacaine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with desipramine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with thiamylal.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with halothane.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with sertraline.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with alclofenac.", "severity": 2}
{"drug1": "gabapentin", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with tranylcypromine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "gabapentin", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with prilocaine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with chlorothiazide.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with quinapril.", "severity": 2}
{"drug1": "gabapentin", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with ethotoin.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METYROSINE is combined with Escitalopram.", "severity": 2}
{"drug1": "HEROIN", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with trimipramine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Retigabine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Fosphenytoin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with MOLINDONE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with trimipramine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Levomilnacipran.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with SERATRODAST.", "severity": 2}
{"drug1": "meprobamate", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with cetirizine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with ROSOXACIN.", "severity": 2}
{"drug1": "pimozide", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Normethadone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with protriptyline.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with ibuprofen.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with butalbital.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with rasagiline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with trimipramine.", "severity": 2}
{"drug1": "Articaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with sertraline.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with lovastatin.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with nalidixic acid.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Levetiracetam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with CYCLIZINE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "diltiazem", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with carvedilol.", "severity": 2}
{"drug1": "zonisamide", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with GUANFACINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with tretinoin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Paliperidone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with prilocaine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with nabumetone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with pramipexole.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with proparacaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with ALFENTANIL.", "severity": 2}
{"drug1": "benzocaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with sertraline.", "severity": 2}
{"drug1": "zonisamide", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with felbamate.", "severity": 2}
{"drug1": "terbinafine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with nisoldipine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with clemastine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "dextromethorphan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with dextromethorphan.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Pefloxacin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with ethanol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "labetalol", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with nicardipine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with Pefloxacin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with linezolid.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Flibanserin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with Tolcapone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with fenbufen.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with tolfenamic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Droxicam.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHSUXIMIDE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "aspirin", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Icatibant.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with CLONIXIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Empagliflozin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "amsacrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with amsacrine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambenonium is combined with Cevimeline.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Pramocaine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with Iloperidone.", "severity": 2}
{"drug1": "pargyline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with formoterol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Propoxycaine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Cis-mdp.", "severity": 2}
{"drug1": "suprofen", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with epirizole.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Escitalopram.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with meclizine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with thiothixene.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "tetracaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with paroxetine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Retigabine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Atracurium besylate.", "severity": 2}
{"drug1": "thalidomide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with methscopolamine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with bromazepam.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with perphenazine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with benazepril.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with amisulpride.", "severity": 2}
{"drug1": "reserpine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "trapidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with trapidil.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "flutamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with flutamide.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BUPRANOLOL is combined with pilocarpine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Ramelteon.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with moclobemide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with alclometasone.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with Escitalopram.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with cyclophosphamide.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Tasimelteon.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with carisoprodol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with prednisone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with haloperidol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with haloperidol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with benzocaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with vigabatrin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with carprofen.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Ketobemidone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with nimesulide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with promethazine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Levalbuterol.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "morphine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with quinapril.", "severity": 2}
{"drug1": "butorphanol", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with lidocaine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with tiapride.", "severity": 2}
{"drug1": "butorphanol", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with clemastine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with butorphanol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with amcinonide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Milnacipran.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "triamterene", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with Riociguat.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Amrinone.", "severity": 2}
{"drug1": "ketamine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ethanol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with Retigabine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with maprotiline.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with flunarizine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with nilvadipine.", "severity": 2}
{"drug1": "clemastine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with triprolidine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NEOSTIGMINE is combined with pilocarpine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with HYDROCODONE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with cinoxacin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with leflunomide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with propofol.", "severity": 2}
{"drug1": "tiapride", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Pomalidomide.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Clobetasone.", "severity": 2}
{"drug1": "tropicamide", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with SUFENTANIL.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Drospirenone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with prazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with quazepam.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with oxprenolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with tetracaine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with isoetharine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Pomalidomide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with bumetanide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Risedronic acid.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Etidocaine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Zoledronic acid.", "severity": 2}
{"drug1": "aspirin", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Halobetasol.", "severity": 2}
{"drug1": "aspirin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with ketorolac.", "severity": 2}
{"drug1": "irbesartan", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with nabumetone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Clodronic Acid.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with imipramine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with loratadine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Icatibant.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with clemastine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with isoxsuprine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Naftifine.", "severity": 2}
{"drug1": "etizolam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with clonazepam.", "severity": 2}
{"drug1": "etizolam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with promethazine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with levorphanol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paricalcitol is combined with digoxin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with nicardipine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with dantrolene.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with estazolam.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Difenoxin.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "clonidine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Metipranolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with levorphanol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "ketamine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Levetiracetam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "ketamine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with DEZOCINE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Ramelteon.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Lormetazepam.", "severity": 2}
{"drug1": "lorazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with triprolidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with spironolactone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with maprotiline.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with celecoxib.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with fexofenadine.", "severity": 2}
{"drug1": "loxapine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Normethadone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Mephobarbital.", "severity": 2}
{"drug1": "etodolac", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Aliskiren.", "severity": 2}
{"drug1": "zopiclone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with ropinirole.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Flibanserin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with sotalol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with trandolapril.", "severity": 2}
{"drug1": "resveratrol", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Droxicam.", "severity": 2}
{"drug1": "estrone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with fleroxacin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with tiapride.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with levodopa.", "severity": 2}
{"drug1": "cilazapril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with antipyrine.", "severity": 2}
{"drug1": "prazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with dipyridamole.", "severity": 2}
{"drug1": "prazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Etidocaine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ticlopidine is combined with Olsalazine.", "severity": 2}
{"drug1": "sotalol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with nadolol.", "severity": 2}
{"drug1": "propofol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with zonisamide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with metoclopramide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with ZILEUTON.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Pramocaine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with felbamate.", "severity": 2}
{"drug1": "Droxicam", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with flumethasone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Propoxycaine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Pramocaine.", "severity": 2}
{"drug1": "loxapine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with etodolac.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Demecarium.", "severity": 2}
{"drug1": "isoflurane", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with penbutolol.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with oxymorphone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Butethal.", "severity": 2}
{"drug1": "isoflurane", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with amobarbital.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with zopiclone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with lithium ion.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Hexobarbital.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Ropivacaine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with bupivacaine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Etomidate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with nitrendipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with quetiapine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with fluvoxamine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with nifedipine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with papaverine.", "severity": 2}
{"drug1": "dapsone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with benzocaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with butamben.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with ondansetron.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "miconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Amrinone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Butethal.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with triflupromazine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with amobarbital.", "severity": 2}
{"drug1": "moclobemide", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with pimozide.", "severity": 2}
{"drug1": "procaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "procaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Melatonin", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with lisinopril.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with scopolamine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Flibanserin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with acetylcholine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with diclofenac.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with nylidrin.", "severity": 2}
{"drug1": "cocaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with baclofen.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with isoxsuprine.", "severity": 2}
{"drug1": "propantheline", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with butorphanol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with suprofen.", "severity": 2}
{"drug1": "glutethimide", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with enoxacin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with sulindac.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Ramelteon.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with chloroquine.", "severity": 2}
{"drug1": "imipramine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with metolazone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Asenapine.", "severity": 2}
{"drug1": "estazolam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with sertraline.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with clonazepam.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "dyclonine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with flunitrazepam.", "severity": 2}
{"drug1": "dyclonine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "triazolam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with oxprenolol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with atorvastatin.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Flibanserin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Pizotifen.", "severity": 2}
{"drug1": "doxepin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Pomalidomide.", "severity": 2}
{"drug1": "sulindac", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Icatibant.", "severity": 2}
{"drug1": "benztropine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with haloperidol.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with prednisone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with aspirin.", "severity": 2}
{"drug1": "bepridil", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "atenolol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with Eplerenone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with BISOPROLOL.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with Difenoxin.", "severity": 2}
{"drug1": "prazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with etizolam.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Pizotifen.", "severity": 2}
{"drug1": "bromazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with clozapine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Escitalopram.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with nitrendipine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with CYCLIZINE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Tasimelteon.", "severity": 2}
{"drug1": "glutethimide", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with prazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clindamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with clindamycin.", "severity": 2}
{"drug1": "glutethimide", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with KETAZOLAM.", "severity": 2}
{"drug1": "glutethimide", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with oxprenolol.", "severity": 2}
{"drug1": "timolol", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Eprosartan.", "severity": 2}
{"drug1": "risperidone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with loratadine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with terazosin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with meclizine.", "severity": 2}
{"drug1": "halothane", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with carvedilol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with tubocurarine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with hydralazine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with oxymorphone.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ibudilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with ibudilast.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with epirizole.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Escitalopram.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with nadolol.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with oxycodone.", "severity": 2}
{"drug1": "azelastine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Pimecrolimus.", "severity": 2}
{"drug1": "temazepam", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with tretinoin.", "severity": 2}
{"drug1": "betaxolol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with metolazone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with prilocaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with triazolam.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with tranylcypromine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with Clodronic Acid.", "severity": 2}
{"drug1": "prednisone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "temazepam", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Halazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Clevidipine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with Pefloxacin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with dexamethasone.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with amitriptyline.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with lithium ion.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with triprolidine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with scopolamine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with methocarbamol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with dantrolene.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with meclizine.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with zotepine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Propoxycaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with nimodipine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Apremilast.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Olopatadine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Etidronic acid.", "severity": 2}
{"drug1": "carprofen", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with hydrocortisone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with amoxapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Fluspirilene.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with thiothixene.", "severity": 2}
{"drug1": "selegiline", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with celecoxib.", "severity": 2}
{"drug1": "nadolol", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with penbutolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with DESFLURANE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with rasagiline.", "severity": 2}
{"drug1": "polythiazide", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when polythiazide is combined with ouabain.", "severity": 2}
{"drug1": "floctafenine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with flunisolide.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with loteprednol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Aceclofenac.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with zaltoprofen.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with nisoldipine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Quinupristin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Quinupristin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with minoxidil.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with chlorzoxazone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with hydrocortisone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with triprolidine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Torasemide.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with ketoprofen.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with flurandrenolide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with dexamethasone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with estazolam.", "severity": 2}
{"drug1": "Trospium", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Metixene.", "severity": 2}
{"drug1": "clorazepate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with dantrolene.", "severity": 2}
{"drug1": "brotizolam", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with GUANFACINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Desloratadine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with DEZOCINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Levetiracetam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Salsalate.", "severity": 2}
{"drug1": "benzocaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with brotizolam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Lormetazepam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Flupentixol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "alclofenac", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with flunisolide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Agomelatine.", "severity": 2}
{"drug1": "meperidine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with bumetanide.", "severity": 2}
{"drug1": "risperidone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Fencamfamin.", "severity": 2}
{"drug1": "risperidone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with lidocaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with prazepam.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Perospirone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "brimonidine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with furosemide.", "severity": 2}
{"drug1": "methysergide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ethanol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with sulpiride.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with hydralazine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Clodronic Acid.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with clonazepam.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Levocetirizine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with betamethasone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with sulpiride.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with promethazine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Bretylium.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with chlorprothixene.", "severity": 2}
{"drug1": "indomethacin", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with NAPROXEN.", "severity": 2}
{"drug1": "brotizolam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with felbamate.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with topiramate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Articaine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with sulpiride.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with digoxin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with fluoxetine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with fleroxacin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with duloxetine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with resveratrol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with procaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with trimipramine.", "severity": 2}
{"drug1": "buspirone", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with propofol.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "pentazocine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with propoxyphene.", "severity": 2}
{"drug1": "pentazocine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with dyclonine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Oxetacaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with gabapentin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with naratriptan.", "severity": 2}
{"drug1": "trimipramine", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with rizatriptan.", "severity": 2}
{"drug1": "trimipramine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with fexofenadine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with fluocinonide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Ramelteon.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with tolmetin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Flupentixol.", "severity": 2}
{"drug1": "furosemide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "triprolidine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with GUANFACINE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "pentoxifylline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with pentoxifylline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with Metipranolol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with dyclonine.", "severity": 2}
{"drug1": "temazepam", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with SUFENTANIL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with propoxyphene.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Ramelteon.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with nifedipine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with levodopa.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with sumatriptan.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with equilin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with papaverine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with METAXALONE.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Lumiracoxib.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with amitriptyline.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Tolcapone.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with daunorubicin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Lormetazepam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Fencamfamin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with celecoxib.", "severity": 2}
{"drug1": "morphine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with bepridil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Articaine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with morphine.", "severity": 2}
{"drug1": "methadone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with meclizine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with chlorothiazide.", "severity": 2}
{"drug1": "selegiline", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with prochlorperazine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "pergolide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with hydralazine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Ziprasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Ziprasidone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Retigabine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with estazolam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with loratadine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with baclofen.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Olsalazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with imipramine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "triazolam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with prazepam.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with clomipramine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with prazosin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "resveratrol", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with SERATRODAST.", "severity": 2}
{"drug1": "carvedilol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "etizolam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with felbamate.", "severity": 2}
{"drug1": "sulpiride", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with primidone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with citalopram.", "severity": 2}
{"drug1": "midazolam", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with diazepam.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with paroxetine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Thioproperazine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Etidocaine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with zolmitriptan.", "severity": 2}
{"drug1": "Perospirone", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with protriptyline.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Etidronic acid.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "droperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with droperidol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with hydrocortisone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with pimozide.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "thiopental", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with lithium ion.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with sertraline.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "clozapine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with enalapril.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "sulfathiazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with sulfathiazole.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Lacidipine.", "severity": 2}
{"drug1": "topiramate", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with loratadine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with methylprednisolone.", "severity": 2}
{"drug1": "topiramate", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with imipramine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with felbamate.", "severity": 2}
{"drug1": "methadone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with chloral hydrate.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with isoxsuprine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "colchicine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with colchicine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with thiothixene.", "severity": 2}
{"drug1": "quazepam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with chloral hydrate.", "severity": 2}
{"drug1": "quazepam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with fludiazepam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with methazolamide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with desipramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Difenoxin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with baclofen.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with amitriptyline.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Tolcapone.", "severity": 2}
{"drug1": "methadone", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Pizotifen.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Butethal.", "severity": 2}
{"drug1": "methadone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with promethazine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Iloperidone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with loratadine.", "severity": 2}
{"drug1": "ketamine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with imipramine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Canagliflozin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with carisoprodol.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with barnidipine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with oxprenolol.", "severity": 2}
{"drug1": "codeine", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with chlorprothixene.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Aripiprazole.", "severity": 2}
{"drug1": "codeine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with clidinium.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with quazepam.", "severity": 2}
{"drug1": "Butethal", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with tetracaine.", "severity": 2}
{"drug1": "pimozide", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Pipotiazine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with fenbufen.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Ethylmorphine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with NAPROXEN.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with dipyridamole.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ketoprofen.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with nitric oxide.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with mefenamic acid.", "severity": 2}
{"drug1": "morphine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with fluvoxamine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with baclofen.", "severity": 2}
{"drug1": "temazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with tiapride.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Risedronic acid.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Linagliptin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Linagliptin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with flunisolide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Temsirolimus.", "severity": 2}
{"drug1": "alprazolam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with amisulpride.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with chlorothiazide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with quinapril.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Tasimelteon.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with bumetanide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with prilocaine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with chlorthalidone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with haloperidol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Mersalyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Mersalyl.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Metipranolol.", "severity": 2}
{"drug1": "triazolam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "reserpine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Retigabine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with primidone.", "severity": 2}
{"drug1": "linezolid", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with trifluoperazine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "ethyl icosapentate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with ethyl icosapentate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Hexobarbital.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Butethal.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with citalopram.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Ketobemidone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with zonisamide.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with pancuronium.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with propofol.", "severity": 2}
{"drug1": "buspirone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with dantrolene.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Iloperidone is combined with Pomalidomide.", "severity": 2}
{"drug1": "buspirone", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with estazolam.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with Vecuronium.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Canagliflozin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Riociguat.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Tapentadol.", "severity": 2}
{"drug1": "Apremilast", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with homoharringtonine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with primidone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with phenobarbital.", "severity": 2}
{"drug1": "methyldopa", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with carvedilol.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with ILOPROST.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with clemastine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with halothane.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with procaine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with phenytoin.", "severity": 2}
{"drug1": "methadone", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with trazodone.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "quinapril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Propacetamol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with D-mannitol.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PONATINIB is combined with clozapine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Halobetasol.", "severity": 2}
{"drug1": "enflurane", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Etomidate.", "severity": 2}
{"drug1": "suprofen", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Tramadol.", "severity": 2}
{"drug1": "promazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with meclizine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with manidipine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Aceprometazine.", "severity": 2}
{"drug1": "caffeine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when caffeine is combined with OLODATEROL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Flibanserin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with butorphanol.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Azelnidipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Desloratadine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with cilnidipine.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with MELPERONE.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with Lacidipine.", "severity": 2}
{"drug1": "prazepam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with MOLINDONE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with rasagiline.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with paroxetine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with DESONIDE.", "severity": 2}
{"drug1": "selegiline", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with triamterene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with triflupromazine.", "severity": 2}
{"drug1": "primidone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with haloperidol.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Articaine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with desoximetasone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Pomalidomide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with desoximetasone.", "severity": 2}
{"drug1": "enflurane", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with scopolamine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with dobutamine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with Halobetasol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with trimipramine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with celecoxib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with MELPERONE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with zotepine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with ibuprofen.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with procaine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with metolazone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with gabapentin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with trimipramine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with clomipramine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with Levocetirizine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with isocarboxazid.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RANOLAZINE is combined with Flibanserin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "loxapine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with ethosuximide.", "severity": 2}
{"drug1": "Metixene", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Ketobemidone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Etidocaine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with clemastine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with epirizole.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when testosterone propionate is combined with tranylcypromine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with triflupromazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Lormetazepam.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Aceprometazine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Pomalidomide.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "vindesine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with vindesine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with carvedilol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with clidinium.", "severity": 2}
{"drug1": "trandolapril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with fenoprofen.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with nimesulide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with terazosin.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with Lacidipine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with clonidine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "dibucaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with felodipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with doxepin.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Darunavir is combined with toremifene.", "severity": 2}
{"drug1": "morphine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with sotalol.", "severity": 2}
{"drug1": "Articaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with fexofenadine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Salbutamol.", "severity": 2}
{"drug1": "Darunavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Darunavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with prednisone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with fleroxacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with ketoprofen.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with pilocarpine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with oxymorphone.", "severity": 2}
{"drug1": "procaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with desipramine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Asenapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "cocaine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "papaverine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with hydralazine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "butamben", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with tiapride.", "severity": 2}
{"drug1": "triazolam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Aripiprazole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with butamben.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Pomalidomide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with ambenonium.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Ditazole.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with butorphanol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Ramelteon.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Melatonin.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Difenoxin.", "severity": 2}
{"drug1": "butorphanol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with bepridil.", "severity": 2}
{"drug1": "rapamycin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with bepridil.", "severity": 2}
{"drug1": "triamterene", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with losartan.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "chloroxine", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with barnidipine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "docetaxel", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with tretinoin.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with nifedipine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with Ciclesonide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Lormetazepam.", "severity": 2}
{"drug1": "chloroquine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Phenelzine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolbutamide is combined with Carbocisteine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with clonazepam.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with desoximetasone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "oxycodone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with promethazine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with trimipramine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Olopatadine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Repaglinide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Repaglinide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Levetiracetam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "metronidazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with metronidazole.", "severity": 2}
{"drug1": "enalapril", "drug2": "diclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with diclofenac.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Almotriptan.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with fluoxetine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with carisoprodol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Tasimelteon.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with duloxetine.", "severity": 2}
{"drug1": "furosemide", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with risperidone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with reserpine.", "severity": 2}
{"drug1": "meperidine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with butamben.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "carprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with flunisolide.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with Propiverine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Fluprednidene.", "severity": 2}
{"drug1": "ketorolac", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Estrone sulfate.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Dimethyl fumarate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with Dimethyl fumarate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with cetirizine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with METAXALONE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with triamcinolone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Teriflunomide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Levomilnacipran.", "severity": 2}
{"drug1": "diclofenac", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with sparfloxacin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Pomalidomide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Naftifine.", "severity": 2}
{"drug1": "midazolam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with desipramine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "primidone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with Milnacipran.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with ethosuximide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Fesoterodine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with amcinonide.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with Tasimelteon.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with etizolam.", "severity": 2}
{"drug1": "loxapine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Flibanserin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Clodronic Acid.", "severity": 2}
{"drug1": "brotizolam", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with phenytoin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Pomalidomide.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with simvastatin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Enasidenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Enasidenib.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with citalopram.", "severity": 2}
{"drug1": "tretinoin", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with terazosin.", "severity": 2}
{"drug1": "butalbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with zotepine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with MELPERONE.", "severity": 2}
{"drug1": "butalbital", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Ramelteon.", "severity": 2}
{"drug1": "bepridil", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with DESFLURANE.", "severity": 2}
{"drug1": "diazepam", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with perphenazine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Efonidipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with levorphanol.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with Risedronic acid.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with mesalamine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Propacetamol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with timolol.", "severity": 2}
{"drug1": "procyclidine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with mecamylamine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with cisapride.", "severity": 2}
{"drug1": "buspirone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with ethosuximide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with fludrocortisone.", "severity": 2}
{"drug1": "selegiline", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Pipotiazine.", "severity": 2}
{"drug1": "cocaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with tetracaine.", "severity": 2}
{"drug1": "ethanol", "drug2": "acetohydroxamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with acetohydroxamic acid.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Bortezomib.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with furosemide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "phentolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with phentolamine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with diflunisal.", "severity": 2}
{"drug1": "secobarbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with METAXALONE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with dexamethasone.", "severity": 2}
{"drug1": "methysergide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clozapine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with amisulpride.", "severity": 2}
{"drug1": "methysergide", "drug2": "vinorelbine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with vinorelbine.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Difenoxin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with dibucaine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with carisoprodol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with sulpiride.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Ropivacaine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Paliperidone.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Flibanserin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with estazolam.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with D-mannitol.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Teriflunomide.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with sotalol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Normethadone.", "severity": 2}
{"drug1": "triamterene", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with methyldopa.", "severity": 2}
{"drug1": "aspirin", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with paramethasone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with loratadine.", "severity": 2}
{"drug1": "aspirin", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "methysergide", "drug2": "Isavuconazonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Isavuconazonium.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with scopolamine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with desoximetasone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Etomidate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with oxaprozin.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with flurandrenolide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with butalbital.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with brotizolam.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with epinephrine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosaprepitant is combined with atorvastatin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "imipramine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with terbutaline.", "severity": 2}
{"drug1": "loxapine", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with meclizine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with hydrocortisone.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with felodipine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with oxprenolol.", "severity": 2}
{"drug1": "clidinium", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with Flibanserin.", "severity": 2}
{"drug1": "loxapine", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with thiothixene.", "severity": 2}
{"drug1": "meprobamate", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with GUANFACINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Tolcapone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with prazepam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with fexofenadine.", "severity": 2}
{"drug1": "valsartan", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with penbutolol.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with Flibanserin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Olopatadine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with felodipine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Bretylium.", "severity": 2}
{"drug1": "HEROIN", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with maprotiline.", "severity": 2}
{"drug1": "triprolidine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with METAXALONE.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with tretinoin.", "severity": 2}
{"drug1": "valsartan", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with triamterene.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "tropicamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with tropicamide.", "severity": 2}
{"drug1": "Metixene", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with ALFENTANIL.", "severity": 2}
{"drug1": "levorphanol", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with trazodone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telaprevir is combined with meperidine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Droxicam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Loxoprofen.", "severity": 2}
{"drug1": "tiapride", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxamine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with Eprosartan.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with vigabatrin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with ropinirole.", "severity": 2}
{"drug1": "apomorphine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with indapamide.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Clevidipine.", "severity": 2}
{"drug1": "sulindac", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with aspirin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with fenoldopam.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with efavirenz.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with Riociguat.", "severity": 2}
{"drug1": "glutethimide", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with chlorzoxazone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Olopatadine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with ethosuximide.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with buprenorphine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with isradipine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Empagliflozin.", "severity": 2}
{"drug1": "aspirin", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with amcinonide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with D-mannitol.", "severity": 2}
{"drug1": "sulindac", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with leflunomide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Alvimopan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with SUFENTANIL.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with atorvastatin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "ERGOTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Butylscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with Butylscopolamine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with risperidone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "epirizole", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with fluocinonide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Isometheptene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Isometheptene.", "severity": 2}
{"drug1": "fenbufen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with flumethasone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with amcinonide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with vigabatrin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with GUANFACINE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with dipyridamole.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Icatibant.", "severity": 2}
{"drug1": "Normethadone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with moclobemide.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Tapentadol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with promethazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with clonazepam.", "severity": 2}
{"drug1": "Normethadone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with metoprolol.", "severity": 2}
{"drug1": "triazolam", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with estazolam.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with Cariprazine.", "severity": 2}
{"drug1": "triazolam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with dantrolene.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nilotinib is combined with atorvastatin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SAQUINAVIR is combined with meperidine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Bretylium.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with nitrous oxide.", "severity": 2}
{"drug1": "felbamate", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with paroxetine.", "severity": 2}
{"drug1": "Artemether", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with gabapentin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Ticagrelor.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Lurasidone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with bumetanide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with METAXALONE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Milnacipran.", "severity": 2}
{"drug1": "reserpine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with quinidine.", "severity": 2}
{"drug1": "triamterene", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with mecamylamine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with terazosin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with methyldopa.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Articaine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with apraclonidine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Phenelzine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Lumiracoxib.", "severity": 2}
{"drug1": "risperidone", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Levetiracetam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with nefazodone.", "severity": 2}
{"drug1": "propofol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with nortriptyline.", "severity": 2}
{"drug1": "propofol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with amoxapine.", "severity": 2}
{"drug1": "propofol", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with benazepril.", "severity": 2}
{"drug1": "isoflurane", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with doxepin.", "severity": 2}
{"drug1": "risperidone", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with DEZOCINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with clidinium.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Oxetacaine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with dichlorphenamide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with acemetacin.", "severity": 2}
{"drug1": "butalbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Butethal", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with Levomilnacipran.", "severity": 2}
{"drug1": "codeine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with clonidine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Fosphenytoin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with nimesulide.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Vecuronium.", "severity": 2}
{"drug1": "apomorphine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with thalidomide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Clevidipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with pentazocine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with quetiapine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with trazodone.", "severity": 2}
{"drug1": "reserpine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with cocaine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with rivastigmine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with ADAPALENE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "etizolam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with citalopram.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Nebivolol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with oxaprozin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Lorcaserin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with tranylcypromine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with prilocaine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Teriflunomide.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with ethotoin.", "severity": 2}
{"drug1": "formestane", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with memantine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with floctafenine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with desoximetasone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "gabapentin", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with pimozide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Desloratadine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Olopatadine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with felbamate.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Apremilast.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with thiopental.", "severity": 2}
{"drug1": "butamben", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Oxetacaine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Telmisartan.", "severity": 2}
{"drug1": "quinapril", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with hydralazine.", "severity": 2}
{"drug1": "indapamide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with methyldopa.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with AMILORIDE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with ethotoin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with ramipril.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with ethosuximide.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with procarbazine.", "severity": 2}
{"drug1": "halothane", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with mecamylamine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Atracurium besylate.", "severity": 2}
{"drug1": "morniflumate", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with fenoprofen.", "severity": 2}
{"drug1": "methysergide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with norfloxacin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with tetracaine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with nalbuphine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "epinephrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with epinephrine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with primidone.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with tiapride.", "severity": 2}
{"drug1": "butenafine", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with PERHEXILINE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with chlormezanone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with dichlorphenamide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Torasemide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Remoxipride.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with enalapril.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with ethosuximide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Cariprazine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Propoxycaine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with Salbutamol.", "severity": 2}
{"drug1": "azelastine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with paramethasone.", "severity": 2}
{"drug1": "zotepine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Pomalidomide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nimodipine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Pipotiazine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with ALFENTANIL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Halazepam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Etoricoxib.", "severity": 2}
{"drug1": "butabarbital", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with proparacaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with paramethasone.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Flibanserin.", "severity": 2}
{"drug1": "amisulpride", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with dantrolene.", "severity": 2}
{"drug1": "azelastine", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with dexamethasone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with venlafaxine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with nadolol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "digitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with digitoxin.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Enalaprilat.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with Tramadol.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with meperidine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with mesoridazine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with maprotiline.", "severity": 2}
{"drug1": "sulfadimethoxine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfadimethoxine is combined with mecamylamine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with antipyrine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with amoxapine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with vigabatrin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Articaine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with thalidomide.", "severity": 2}
{"drug1": "terazosin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Empagliflozin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Ketobemidone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with clonazepam.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with promethazine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with nifedipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Levobupivacaine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with fexofenadine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with KETAZOLAM.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "pentazocine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with fluocinonide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Desloratadine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "morphine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Lurasidone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with chloral hydrate.", "severity": 2}
{"drug1": "dibucaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with clonidine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with fludiazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Olopatadine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with ritodrine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with papaverine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with clonazepam.", "severity": 2}
{"drug1": "oxazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with promethazine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Pregabalin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with methazolamide.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Eplerenone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Melatonin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "etodolac", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with sulfasalazine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "selegiline", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with pramipexole.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ARBUTAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with ARBUTAMINE.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Iloperidone.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with scopolamine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "nicergoline", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with irbesartan.", "severity": 2}
{"drug1": "diflorasone", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with malathion.", "severity": 2}
{"drug1": "amobarbital", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with METAXALONE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with amisulpride.", "severity": 2}
{"drug1": "imipramine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Canagliflozin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Agomelatine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with etodolac.", "severity": 2}
{"drug1": "clozapine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with penbutolol.", "severity": 2}
{"drug1": "morniflumate", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with ZILEUTON.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Hexobarbital.", "severity": 2}
{"drug1": "benzocaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with zotepine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with MELPERONE.", "severity": 2}
{"drug1": "clozapine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with amobarbital.", "severity": 2}
{"drug1": "nicergoline", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with doxorubicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with benzocaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with vigabatrin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with cetirizine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with desoximetasone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with felbamate.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "aspirin", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Lornoxicam.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with lisinopril.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with desipramine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with thiamylal.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Difenoxin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with estrone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with topiramate.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with halothane.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "indomethacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with indomethacin.", "severity": 2}
{"drug1": "diazepam", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Aliskiren.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Halobetasol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "benazepril", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with flurbiprofen.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Iloperidone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ouabain", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with ouabain.", "severity": 2}
{"drug1": "meperidine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with zaleplon.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with cetirizine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with betamethasone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Telmisartan.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with apraclonidine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Desloratadine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with HEROIN.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with zaltoprofen.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with Aceclofenac.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "etodolac", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with captopril.", "severity": 2}
{"drug1": "isoflurane", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with methoxyflurane.", "severity": 2}
{"drug1": "etodolac", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with fenbufen.", "severity": 2}
{"drug1": "Torasemide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with irbesartan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with scopolamine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Difenoxin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Fluspirilene.", "severity": 2}
{"drug1": "Torasemide", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with felodipine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with sulpiride.", "severity": 2}
{"drug1": "butabarbital", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with carisoprodol.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with fenbufen.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with procaine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with donepezil.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with hydralazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Propoxycaine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with mirtazapine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with thiamylal.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with citalopram.", "severity": 2}
{"drug1": "diazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "butabarbital", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with benzyl alcohol.", "severity": 2}
{"drug1": "tiagabine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with desipramine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with tretinoin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Pomalidomide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with bromazepam.", "severity": 2}
{"drug1": "diazepam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Pomalidomide.", "severity": 2}
{"drug1": "practolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when practolol is combined with Cevimeline.", "severity": 2}
{"drug1": "Perospirone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with meclizine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Fluspirilene.", "severity": 2}
{"drug1": "enalapril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with cilazapril.", "severity": 2}
{"drug1": "minoxidil", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with isoxsuprine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with fludrocortisone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with nisoldipine.", "severity": 2}
{"drug1": "terazosin", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Cis-mdp.", "severity": 2}
{"drug1": "Perospirone", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with promethazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with clonazepam.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with enoxacin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Quinine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Quinine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with Milnacipran.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with terazosin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with antipyrine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with procaine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with codeine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Eplerenone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with estazolam.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with antipyrine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with midazolam.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PRIMAQUINE is combined with NITROUS ACID.", "severity": 2}
{"drug1": "butorphanol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with dantrolene.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Nitroprusside.", "severity": 2}
{"drug1": "butabarbital", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with desipramine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Propoxycaine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Pramocaine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with amoxapine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with nortriptyline.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Eprosartan.", "severity": 2}
{"drug1": "Butethal", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with butamben.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with Tixocortol.", "severity": 2}
{"drug1": "metolazone", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with nadolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with furosemide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with methocarbamol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with triprolidine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with digoxin.", "severity": 2}
{"drug1": "bumetanide", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with sulpiride.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with acemetacin.", "severity": 2}
{"drug1": "methadone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with HEROIN.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with methocarbamol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with brotizolam.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with triprolidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with Metipranolol.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Pomalidomide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with baclofen.", "severity": 2}
{"drug1": "flunarizine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with nefazodone.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with oxaprozin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with trazodone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with enflurane.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with Gemifloxacin.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with flurbiprofen.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with acebutolol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Efonidipine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Fospropofol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with halcinonide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "medrysone", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with tubocurarine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Alvimopan.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with tiagabine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with nitric oxide.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Olopatadine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with etodolac.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Ramelteon.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with ZILEUTON.", "severity": 2}
{"drug1": "amifostine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with ESMOLOL.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with hydrocortisone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with chlorthalidone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Nebivolol.", "severity": 2}
{"drug1": "cocaine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Fluspirilene.", "severity": 2}
{"drug1": "budesonide", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with norfloxacin.", "severity": 2}
{"drug1": "propofol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with thiopental.", "severity": 2}
{"drug1": "budesonide", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with Echothiophate.", "severity": 2}
{"drug1": "brimonidine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with Demecarium.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with propranolol.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clarithromycin is combined with oxycodone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with imipramine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with morphine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with isocarboxazid.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Perospirone.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with MOLINDONE.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Oxetacaine.", "severity": 2}
{"drug1": "clemastine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Benidipine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with pravastatin.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with nicardipine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with isoxsuprine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with methadone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "phenobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with phenobarbital.", "severity": 2}
{"drug1": "tretinoin", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with hydralazine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with fludrocortisone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with memantine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with oxaprozin.", "severity": 2}
{"drug1": "quinapril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with carvedilol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with etizolam.", "severity": 2}
{"drug1": "clonidine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with maprotiline.", "severity": 2}
{"drug1": "thalidomide", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with quinapril.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with chlorothiazide.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with morphine.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with vigabatrin.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Ropivacaine.", "severity": 2}
{"drug1": "dobutamine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with clenbuterol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with lansoprazole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with chloramphenicol.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with methazolamide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with teniposide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with betamethasone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with zotepine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with MELPERONE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with flumethasone.", "severity": 2}
{"drug1": "diazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with flunarizine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Etidocaine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with enalapril.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with prazosin.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with scopolamine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with SERTINDOLE.", "severity": 2}
{"drug1": "felodipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfamethoxazole is combined with atorvastatin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with benzyl alcohol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with amcinonide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with irbesartan.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with protriptyline.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Pramocaine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Propoxycaine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with clonazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with promethazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with doxepin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with ambenonium.", "severity": 2}
{"drug1": "minoxidil", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Melatonin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "methysergide", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with furosemide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with flunitrazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with olanzapine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with DESFLURANE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Nepafenac.", "severity": 2}
{"drug1": "meperidine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Articaine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with fludiazepam.", "severity": 2}
{"drug1": "imipramine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "meperidine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Cyamemazine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Pizotifen.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetrahydrozoline is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Fencamfamin.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with methyldopa.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "rescinnamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Saxagliptin is combined with rescinnamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with amitriptyline.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Tolcapone.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Iloperidone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Pipamperone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with xylometazoline.", "severity": 2}
{"drug1": "benztropine", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with oxyphenonium.", "severity": 2}
{"drug1": "theophylline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when theophylline is combined with formoterol.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with cilnidipine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with butamben.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with isradipine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with flumethasone.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Olmesartan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Retigabine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with Azelnidipine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with zaltoprofen.", "severity": 2}
{"drug1": "trazodone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with ethotoin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Estrone sulfate.", "severity": 2}
{"drug1": "trazodone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with prilocaine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprenolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with norfloxacin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with Echothiophate.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Ibrutinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Ibrutinib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with medrysone.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with eperisone.", "severity": 2}
{"drug1": "morphine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with triamterene.", "severity": 2}
{"drug1": "zaleplon", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with fludiazepam.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with acemetacin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with naratriptan.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with eperisone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Pipamperone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with Desloratadine.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with methscopolamine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Flibanserin.", "severity": 2}
{"drug1": "terazosin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Clevidipine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with flunarizine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with homoharringtonine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with desipramine.", "severity": 2}
{"drug1": "morphine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "tolazoline", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with methyclothiazide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with metolazone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Tolcapone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Etoricoxib.", "severity": 2}
{"drug1": "reserpine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with brotizolam.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Nebivolol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with homoharringtonine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with metaproterenol.", "severity": 2}
{"drug1": "pancuronium", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with SUFENTANIL.", "severity": 2}
{"drug1": "quazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "equilin", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with Deferasirox.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with tiapride.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Clevidipine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Paliperidone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Milnacipran.", "severity": 2}
{"drug1": "floctafenine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with homoharringtonine.", "severity": 2}
{"drug1": "cetirizine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with amoxapine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with oxprenolol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Cis-mdp.", "severity": 2}
{"drug1": "Mometasone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "azelastine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with loteprednol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with ropinirole.", "severity": 2}
{"drug1": "lorazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Salbutamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Salbutamol.", "severity": 2}
{"drug1": "dibucaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with meclizine.", "severity": 2}
{"drug1": "etizolam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with butamben.", "severity": 2}
{"drug1": "methysergide", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with quinidine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with etizolam.", "severity": 2}
{"drug1": "reserpine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Agomelatine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with dibucaine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with acemetacin.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with fexofenadine.", "severity": 2}
{"drug1": "argatroban", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when argatroban is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with protriptyline.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with cetirizine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with propofol.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with irbesartan.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Normethadone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Desloratadine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "mechlorethamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with mechlorethamine.", "severity": 2}
{"drug1": "imipramine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with valsartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with fexofenadine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Dexrazoxane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Dexrazoxane.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Salsalate.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with memantine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEFLAZACORT is combined with Gatifloxacin.", "severity": 2}
{"drug1": "codeine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with carisoprodol.", "severity": 2}
{"drug1": "trazodone", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with thiamylal.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BREXPIPRAZOLE is combined with methylphenidate.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with cilazapril.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with irbesartan.", "severity": 2}
{"drug1": "Asenapine", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with chlorzoxazone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with Thioproperazine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with D-mannitol.", "severity": 2}
{"drug1": "carprofen", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Zoledronic acid.", "severity": 2}
{"drug1": "carprofen", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with timolol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with D-mannitol.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with dicyclomine.", "severity": 2}
{"drug1": "propofol", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with trifluoperazine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with felbamate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Butethal.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Hexobarbital.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Apremilast.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with spironolactone.", "severity": 2}
{"drug1": "timolol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with spironolactone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with dichlorphenamide.", "severity": 2}
{"drug1": "carprofen", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Etoricoxib.", "severity": 2}
{"drug1": "Nabilone", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with propranolol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Tasimelteon.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with ethotoin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with papaverine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with mesalamine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with alclometasone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with nifedipine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when duloxetine is combined with Perospirone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with fosinopril.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Butethal.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "dibucaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with lithium ion.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Pramocaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with dibucaine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with aspirin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with felbamate.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Trospium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with Trospium.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Rotigotine.", "severity": 2}
{"drug1": "timolol", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with nimodipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with antipyrine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Telmisartan.", "severity": 2}
{"drug1": "butalbital", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with chlorzoxazone.", "severity": 2}
{"drug1": "ketamine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Aceprometazine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with methyldopa.", "severity": 2}
{"drug1": "ketamine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with MOLINDONE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Etidocaine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with polythiazide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ethyl icosapentate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with ethyl icosapentate.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "PRIMAQUINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with butamben.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with Aceprometazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with pilocarpine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Sacubitril.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with norfloxacin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Riociguat.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Lofexidine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Risedronic acid.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Cyamemazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Remoxipride.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Paliperidone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with fenoprofen.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with estrone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with diltiazem.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with epirizole.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with Olopatadine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with scopolamine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Cangrelor is combined with aspirin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Pomalidomide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "procaine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Fospropofol.", "severity": 2}
{"drug1": "dobutamine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with Ephedrine.", "severity": 2}
{"drug1": "propofol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Riociguat.", "severity": 2}
{"drug1": "dobutamine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dobutamine is combined with PROCATEROL.", "severity": 2}
{"drug1": "acemetacin", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with flunisolide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with tiapride.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with spironolactone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nifedipine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with bromocriptine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with DESFLURANE.", "severity": 2}
{"drug1": "ketamine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with quetiapine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with oxycodone.", "severity": 2}
{"drug1": "Gabapentin enacarbil", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Gabapentin enacarbil is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Pregabalin.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Olopatadine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with methylphenidate.", "severity": 2}
{"drug1": "haloperidol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with methocarbamol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Paliperidone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with triprolidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Tasimelteon.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with dexamethasone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with acebutolol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with zotepine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with SERTINDOLE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with indapamide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when galanthamine is combined with Cevimeline.", "severity": 2}
{"drug1": "galanthamine", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when galanthamine is combined with nicotine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Halazepam.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with proparacaine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Torasemide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with flunarizine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with diflorasone.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Pipamperone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with suprofen.", "severity": 2}
{"drug1": "prilocaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with butamben.", "severity": 2}
{"drug1": "enflurane", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Pramocaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with zonisamide.", "severity": 2}
{"drug1": "enflurane", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Propoxycaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ondansetron.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with cocaine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with tiagabine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with Fluprednidene.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with dibucaine.", "severity": 2}
{"drug1": "codeine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with flunitrazepam.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Difenoxin.", "severity": 2}
{"drug1": "sulpiride", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with loratadine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Canagliflozin.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with topiramate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with acemetacin.", "severity": 2}
{"drug1": "benztropine", "drug2": "cyclopentolate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with cyclopentolate.", "severity": 2}
{"drug1": "promethazine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with periciazine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with topiramate.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with isradipine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with baclofen.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Levetiracetam.", "severity": 2}
{"drug1": "rasagiline", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with dipyridamole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with Fluspirilene.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with glutethimide.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with vigabatrin.", "severity": 2}
{"drug1": "promazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with etizolam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Methadyl acetate.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with nifedipine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with benzocaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with clorazepate.", "severity": 2}
{"drug1": "midazolam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with loratadine.", "severity": 2}
{"drug1": "labetalol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with methazolamide.", "severity": 2}
{"drug1": "labetalol", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with Eplerenone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with imipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Levobupivacaine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with efavirenz.", "severity": 2}
{"drug1": "temazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with olanzapine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with trimipramine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with difluprednate.", "severity": 2}
{"drug1": "epinephrine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with dopamine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with efavirenz.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "estazolam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Olopatadine.", "severity": 2}
{"drug1": "ramipril", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with antipyrine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Perospirone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with methazolamide.", "severity": 2}
{"drug1": "amisulpride", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with amitriptyline.", "severity": 2}
{"drug1": "baclofen", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Desloratadine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Pizotifen.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "clozapine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with chlorthalidone.", "severity": 2}
{"drug1": "clozapine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Eprosartan.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with nimodipine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with cilazapril.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with oxycodone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Canagliflozin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with ibuprofen.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloramphenicol is combined with ethanol.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with citalopram.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with AMILORIDE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with paroxetine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with quinidine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with amoxapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with mefloquine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with tizanidine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with furosemide.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with mirtazapine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fosamprenavir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "pergolide", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with chlorzoxazone.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with fluocinonide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with furosemide.", "severity": 2}
{"drug1": "quinapril", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with tenoxicam.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with tizanidine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with scopolamine.", "severity": 2}
{"drug1": "nystatin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with mefloquine.", "severity": 2}
{"drug1": "risperidone", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with zaleplon.", "severity": 2}
{"drug1": "quinapril", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with nabumetone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with enflurane.", "severity": 2}
{"drug1": "risperidone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with mepivacaine.", "severity": 2}
{"drug1": "quinapril", "drug2": "ketorolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ketorolac.", "severity": 2}
{"drug1": "nicergoline", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with irinotecan.", "severity": 2}
{"drug1": "nicergoline", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with methimazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with trimipramine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with imipramine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with loratadine.", "severity": 2}
{"drug1": "ketamine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with meclizine.", "severity": 2}
{"drug1": "estazolam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with protriptyline.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Fencamfamin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with desipramine.", "severity": 2}
{"drug1": "estazolam", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with cetirizine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with ketamine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "malathion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with malathion.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ramipril", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with D-mannitol.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Gemifloxacin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with ethosuximide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with nalidixic acid.", "severity": 2}
{"drug1": "ramipril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with etodolac.", "severity": 2}
{"drug1": "nimodipine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with clonidine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with oxycodone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "methysergide", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Conivaptan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with tiagabine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with sulpiride.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with epoprostenol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with carisoprodol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Ramelteon.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with isocarboxazid.", "severity": 2}
{"drug1": "citalopram", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citalopram is combined with Perospirone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with zonisamide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with equilin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "estazolam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with tizanidine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with PAMABROM.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with zaleplon.", "severity": 2}
{"drug1": "dyclonine", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with phenytoin.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Articaine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with cinoxacin.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with metoclopramide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with flumethasone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with enflurane.", "severity": 2}
{"drug1": "meprobamate", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with clorazepate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Etoricoxib.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with GUANFACINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with thiothixene.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Conivaptan.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Eprosartan.", "severity": 2}
{"drug1": "buspirone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Melatonin.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Vinflunine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with Vinflunine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with sevoflurane.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with tetracaine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with promethazine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with clonazepam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "OLODATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with OLODATEROL.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with nifedipine.", "severity": 2}
{"drug1": "halothane", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ethotoin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Pipotiazine.", "severity": 2}
{"drug1": "glipizide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glipizide is combined with ethanol.", "severity": 2}
{"drug1": "formestane", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with metoclopramide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Pipamperone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Rotigotine.", "severity": 2}
{"drug1": "propofol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Pizotifen.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with triflupromazine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with flurandrenolide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with ethosuximide.", "severity": 2}
{"drug1": "meprobamate", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "gabapentin", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with thiamylal.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with thiopental.", "severity": 2}
{"drug1": "Limaprost", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with Ditazole.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Nebivolol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Alogliptin is combined with enalapril.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with triamterene.", "severity": 2}
{"drug1": "meperidine", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with sulpiride.", "severity": 2}
{"drug1": "estazolam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with dyclonine.", "severity": 2}
{"drug1": "meperidine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with carisoprodol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Ketobemidone.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with cetirizine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with mecamylamine.", "severity": 2}
{"drug1": "estazolam", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with chloral hydrate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with DESONIDE.", "severity": 2}
{"drug1": "estazolam", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with fludiazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with miconazole.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with AMILORIDE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with doxazosin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Paliperidone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with niflumic acid.", "severity": 2}
{"drug1": "perphenazine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with fenoprofen.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Escitalopram.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "oxazepam", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with budesonide.", "severity": 2}
{"drug1": "dibucaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Amrinone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with medrysone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with azelastine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with chlormezanone.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "perphenazine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with glutethimide.", "severity": 2}
{"drug1": "midazolam", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Difenoxin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with chlorzoxazone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with pentazocine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with DESFLURANE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with triflupromazine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Levomepromazine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Mometasone.", "severity": 2}
{"drug1": "suprofen", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with zaltoprofen.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with triamterene.", "severity": 2}
{"drug1": "suprofen", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with SERATRODAST.", "severity": 2}
{"drug1": "meperidine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with mesoridazine.", "severity": 2}
{"drug1": "doxepin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "thiopental", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Methadyl acetate.", "severity": 2}
{"drug1": "thiopental", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with glutethimide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Pipamperone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with Perospirone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with loxapine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Remoxipride.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Agomelatine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Fluspirilene.", "severity": 2}
{"drug1": "nabumetone", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with flurbiprofen.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Olopatadine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "NEOSTIGMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with NEOSTIGMINE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Normethadone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with Dapagliflozin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with atorvastatin.", "severity": 2}
{"drug1": "baclofen", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Propiverine.", "severity": 2}
{"drug1": "midazolam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with brotizolam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "loxapine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with loratadine.", "severity": 2}
{"drug1": "methysergide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "Butethal", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "equilin", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when equilin is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Artemether", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with Clevidipine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Flupentixol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Eprosartan.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with sparfloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with azelastine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with etodolac.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with quetiapine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with dantrolene.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Eprosartan.", "severity": 2}
{"drug1": "butamben", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with cetirizine.", "severity": 2}
{"drug1": "morphine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "butamben", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with protriptyline.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with quinapril.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with buprenorphine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with alclofenac.", "severity": 2}
{"drug1": "antipyrine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with acemetacin.", "severity": 2}
{"drug1": "selegiline", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with hydromorphone.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with oxymorphone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Levetiracetam.", "severity": 2}
{"drug1": "enalapril", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Naftifine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with sevoflurane.", "severity": 2}
{"drug1": "furazolidone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with maprotiline.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with fosinopril.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with Normethadone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Aripiprazole.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with Eprosartan.", "severity": 2}
{"drug1": "temazepam", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with doxepin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with formestane.", "severity": 2}
{"drug1": "nicardipine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Imatinib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Imatinib is combined with atorvastatin.", "severity": 2}
{"drug1": "loxapine", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with amoxapine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with phenytoin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Pipotiazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Thioproperazine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with Escitalopram.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Pipotiazine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with clozapine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "benazepril", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with furosemide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "aspirin", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with alclofenac.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with metoprolol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with ropinirole.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with Ketobemidone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with meperidine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with flumethasone.", "severity": 2}
{"drug1": "butamben", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Desloratadine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with nitrazepam.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with ethotoin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with alclometasone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Perospirone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Zucapsaicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Zucapsaicin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Pomalidomide.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with quinapril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with methocarbamol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with methylphenidate.", "severity": 2}
{"drug1": "thioridazine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with spironolactone.", "severity": 2}
{"drug1": "benazepril", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with apraclonidine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Levocetirizine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with methylprednisolone.", "severity": 2}
{"drug1": "benazepril", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with methyldopa.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with quetiapine.", "severity": 2}
{"drug1": "trazodone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with etizolam.", "severity": 2}
{"drug1": "tetracaine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with primidone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with pravastatin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with topiramate.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "pimozide", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with ondansetron.", "severity": 2}
{"drug1": "Asenapine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with butamben.", "severity": 2}
{"drug1": "pimozide", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with tiagabine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with nimesulide.", "severity": 2}
{"drug1": "pimozide", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with zonisamide.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with donepezil.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with sulfasalazine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with tiagabine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with cocaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with ondansetron.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with felbamate.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with zonisamide.", "severity": 2}
{"drug1": "promazine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with GUANFACINE.", "severity": 2}
{"drug1": "proparacaine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with benzocaine.", "severity": 2}
{"drug1": "promazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with MELPERONE.", "severity": 2}
{"drug1": "promazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with zotepine.", "severity": 2}
{"drug1": "chloroxine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with nisoldipine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with desipramine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with flunarizine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with halothane.", "severity": 2}
{"drug1": "resveratrol", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with fluocinonide.", "severity": 2}
{"drug1": "selegiline", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with doxepin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trichlormethiazide is combined with carbamazepine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with maprotiline.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with mesoridazine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "carprofen", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Icatibant.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with daunorubicin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with amoxapine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with nortriptyline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "secobarbital", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with prilocaine.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with nalbuphine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with Deferasirox.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with flunisolide.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with nimesulide.", "severity": 2}
{"drug1": "gabapentin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with diphenhydramine.", "severity": 2}
{"drug1": "pimozide", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with meclizine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "reserpine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with protriptyline.", "severity": 2}
{"drug1": "diazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "reserpine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with cetirizine.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Fencamfamin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "doxycycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with doxycycline.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paramethasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "amifostine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with triamterene.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Aceprometazine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Bambuterol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "diflunisal", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with homoharringtonine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with zaleplon.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with mepivacaine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with resveratrol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with hydralazine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with imipramine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with metaproterenol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Fluprednidene.", "severity": 2}
{"drug1": "Droxicam", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with citalopram.", "severity": 2}
{"drug1": "promazine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Olopatadine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with NITROUS ACID.", "severity": 2}
{"drug1": "tiapride", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with felbamate.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "isradipine", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with diltiazem.", "severity": 2}
{"drug1": "Torasemide", "drug2": "daunorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with daunorubicin.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with methocarbamol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with spironolactone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with triprolidine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with topiramate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Lormetazepam.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with DEZOCINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with clomipramine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with isocarboxazid.", "severity": 2}
{"drug1": "budesonide", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with Gemifloxacin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with fenbufen.", "severity": 2}
{"drug1": "haloperidol", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with clorazepate.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Torasemide.", "severity": 2}
{"drug1": "loratadine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Iloperidone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with MELPERONE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with zotepine.", "severity": 2}
{"drug1": "estramustine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estramustine is combined with leflunomide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with tolazoline.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Pipamperone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with benzyl alcohol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with terazosin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "midazolam", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with amobarbital.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with xylometazoline.", "severity": 2}
{"drug1": "midazolam", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Butethal.", "severity": 2}
{"drug1": "fosinopril", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with penbutolol.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with ropinirole.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tasimelteon is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with indapamide.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Milnacipran.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with homoharringtonine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Desloratadine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with procaine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with trimipramine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Cis-mdp.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Aceprometazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with perphenazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with levorphanol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with medrysone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with risperidone.", "severity": 2}
{"drug1": "clemastine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "clidinium", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clidinium is combined with citalopram.", "severity": 2}
{"drug1": "perphenazine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with triprolidine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Difenoxin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with methylphenidate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with methocarbamol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with ethotoin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with Apremilast.", "severity": 2}
{"drug1": "methysergide", "drug2": "Telaprevir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Telaprevir.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with nisoldipine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with clemastine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "CAPECITABINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with CAPECITABINE.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Ketobemidone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "rosiglitazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with rosiglitazone.", "severity": 2}
{"drug1": "THYMOL", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with xylometazoline.", "severity": 2}
{"drug1": "methadone", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Lurasidone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with ethosuximide.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bretylium is combined with Riociguat.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "temozolomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with temozolomide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "dacarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with dacarbazine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with thiopental.", "severity": 2}
{"drug1": "promazine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with cocaine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with tiapride.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Flibanserin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with chlorthalidone.", "severity": 2}
{"drug1": "ramipril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naltrexone is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with doxorubicin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with oxaprozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "azathioprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with azathioprine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with isoxsuprine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with Nepafenac.", "severity": 2}
{"drug1": "proparacaine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with ethotoin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with brimonidine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with methoxyflurane.", "severity": 2}
{"drug1": "Etomidate", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with tetracaine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Flibanserin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Tasimelteon.", "severity": 2}
{"drug1": "flumethasone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flumethasone is combined with pyridostigmine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "trichlormethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with trichlormethiazide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Potassium citrate.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with butorphanol.", "severity": 2}
{"drug1": "Articaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with METAXALONE.", "severity": 2}
{"drug1": "ethotoin", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with tiagabine.", "severity": 2}
{"drug1": "triamterene", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BALSALAZIDE is combined with medrysone.", "severity": 2}
{"drug1": "morphine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with quetiapine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Nepafenac.", "severity": 2}
{"drug1": "nimodipine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with doxazosin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with progesterone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Sacubitril.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Sorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Sorafenib.", "severity": 2}
{"drug1": "proparacaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with clemastine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Varenicline.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with vigabatrin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with hydralazine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with triprolidine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with nilvadipine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with methocarbamol.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with alclometasone.", "severity": 2}
{"drug1": "Benidipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with atorvastatin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Gatifloxacin.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with manidipine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with hydrocortisone.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levetiracetam is combined with Difenoxin.", "severity": 2}
{"drug1": "butalbital", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with promethazine.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mitoxantrone is combined with leflunomide.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Azelnidipine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with decamethonium.", "severity": 2}
{"drug1": "etizolam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with meclizine.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Lacidipine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Oxetacaine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with halcinonide.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with ethosuximide.", "severity": 2}
{"drug1": "codeine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with difluprednate.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "carbamazepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with carbamazepine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Perospirone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "bepridil", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "HEROIN", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with etizolam.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Iloperidone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with Amrinone.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with cinnarizine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Pipotiazine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with thiothixene.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levocetirizine is combined with sertraline.", "severity": 2}
{"drug1": "morphine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with valsartan.", "severity": 2}
{"drug1": "clorazepate", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with MOLINDONE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with nimesulide.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with carprofen.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Difenoxin.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Salsalate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "caffeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with caffeine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "azithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with azithromycin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with reserpine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with thiamylal.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with Iloperidone.", "severity": 2}
{"drug1": "ramipril", "drug2": "Nepafenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Nepafenac.", "severity": 2}
{"drug1": "proparacaine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with desipramine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with Perospirone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "promazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Flibanserin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Pipotiazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with thiothixene.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with imipramine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with Normethadone.", "severity": 2}
{"drug1": "benazepril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with fenoprofen.", "severity": 2}
{"drug1": "hexetidine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hexetidine is combined with nimodipine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with nalbuphine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with efavirenz.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with oxazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Ramelteon.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with Aripiprazole.", "severity": 2}
{"drug1": "paroxetine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with chlorprothixene.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with niflumic acid.", "severity": 2}
{"drug1": "Normethadone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with clomipramine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with methazolamide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with teniposide.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Pramocaine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Propoxycaine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with nefazodone.", "severity": 2}
{"drug1": "dimethyl sulfoxide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dimethyl sulfoxide is combined with atorvastatin.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Iloperidone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with brotizolam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "carmustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with carmustine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "anagrelide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with anagrelide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Loxoprofen.", "severity": 2}
{"drug1": "codeine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with chlorpheniramine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with lisinopril.", "severity": 2}
{"drug1": "procyclidine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Retigabine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with VERAPAMIL.", "severity": 2}
{"drug1": "risperidone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with chlormezanone.", "severity": 2}
{"drug1": "risperidone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "benztropine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with dipyridamole.", "severity": 2}
{"drug1": "etizolam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Oxetacaine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with salicylamide.", "severity": 2}
{"drug1": "isradipine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with doxazosin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Teriflunomide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with terazosin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with doxepin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with medrysone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Flupentixol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Conivaptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Conivaptan.", "severity": 2}
{"drug1": "procyclidine", "drug2": "tropicamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with tropicamide.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with nifedipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Pramocaine.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with Propoxycaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Pomalidomide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with MOLINDONE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "oxycodone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Aceprometazine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with amisulpride.", "severity": 2}
{"drug1": "Asenapine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with MOLINDONE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Levocetirizine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with fluvoxamine.", "severity": 2}
{"drug1": "losartan", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with niflumic acid.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with sulindac.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Mirabegron.", "severity": 2}
{"drug1": "losartan", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Eprosartan.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with epirizole.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with SERATRODAST.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with chloroquine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Tolcapone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Aripiprazole.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with propoxyphene.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with ANISOTROPINE METHYLBROMIDE.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with losartan.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with thioridazine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Etidronic acid.", "severity": 2}
{"drug1": "ondansetron", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with clidinium.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Ramelteon.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with buprenorphine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with pravastatin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Canagliflozin.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with dipyridamole.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with rasagiline.", "severity": 2}
{"drug1": "losartan", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "meperidine", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with periciazine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with sevoflurane.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with duloxetine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with nabumetone.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with fluoxetine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with Ephedrine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "tenoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with tenoxicam.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with tiagabine.", "severity": 2}
{"drug1": "baclofen", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with butalbital.", "severity": 2}
{"drug1": "triprolidine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with paroxetine.", "severity": 2}
{"drug1": "enflurane", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with mesoridazine.", "severity": 2}
{"drug1": "aspirin", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with budesonide.", "severity": 2}
{"drug1": "halothane", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with fexofenadine.", "severity": 2}
{"drug1": "enflurane", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with maprotiline.", "severity": 2}
{"drug1": "diltiazem", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with doxazosin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Flibanserin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with AMILORIDE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with isoxsuprine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "oxybutynin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with oxybutynin.", "severity": 2}
{"drug1": "cytarabine", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cytarabine is combined with leflunomide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with diflorasone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with Tasimelteon.", "severity": 2}
{"drug1": "secobarbital", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with quetiapine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "oxaliplatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with oxaliplatin.", "severity": 2}
{"drug1": "Metixene", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with codeine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Perospirone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with protriptyline.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pinaverium is combined with Pitavastatin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Pipamperone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with cetirizine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with betamethasone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with chlorthalidone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Pizotifen.", "severity": 2}
{"drug1": "pentazocine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with nitrazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Levalbuterol.", "severity": 2}
{"drug1": "pergolide", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Lornoxicam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with oxaprozin.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Apremilast.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with Enalaprilat.", "severity": 2}
{"drug1": "oxazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with clozapine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Agomelatine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Pomalidomide.", "severity": 2}
{"drug1": "glutethimide", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with METAXALONE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Hexobarbital.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with lithium ion.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with estrone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Butethal.", "severity": 2}
{"drug1": "Luliconazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Luliconazole is combined with oxycodone.", "severity": 2}
{"drug1": "chloroxine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with nifedipine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with tetracaine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "propantheline", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with dicyclomine.", "severity": 2}
{"drug1": "propantheline", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with ALFENTANIL.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with Iloperidone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with meclofenamic acid.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Fencamfamin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methazolamide is combined with Bretylium.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with sertraline.", "severity": 2}
{"drug1": "pentazocine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with nitrazepam.", "severity": 2}
{"drug1": "topiramate", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with trimipramine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with risperidone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Fospropofol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nitrazepam.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with fluvastatin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with paramethasone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with tizanidine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with ethosuximide.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicotinamide is combined with Rosuvastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Difenoxin.", "severity": 2}
{"drug1": "cerulenin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with barnidipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with enflurane.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Agomelatine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with formestane.", "severity": 2}
{"drug1": "butabarbital", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Olopatadine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "codeine", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with PAMABROM.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with formestane.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "perphenazine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with flunitrazepam.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with isoxsuprine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with cetirizine.", "severity": 2}
{"drug1": "clozapine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with triflupromazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "captopril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Metipranolol.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Fosamprenavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with Fosamprenavir.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "sulindac", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "butenafine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with Pregabalin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Normethadone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "MOXONIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with MOXONIDINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "6-Mercaptopurine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with methylprednisolone.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Teriflunomide.", "severity": 2}
{"drug1": "promazine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with METAXALONE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with MELPERONE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with brotizolam.", "severity": 2}
{"drug1": "pergolide", "drug2": "Sitaxsentan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Sitaxsentan.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with tetracaine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with sulfasalazine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "mycophenolate mofetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with tretinoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with flunitrazepam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "methadone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Eplerenone.", "severity": 2}
{"drug1": "bumetanide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with hydralazine.", "severity": 2}
{"drug1": "desipramine", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with metaproterenol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with pancuronium.", "severity": 2}
{"drug1": "felbamate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Normethadone.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "PIPECURONIUM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with PIPECURONIUM.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Vecuronium.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with ethchlorvynol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with estazolam.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with Clevidipine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimetrexate is combined with bepridil.", "severity": 2}
{"drug1": "clorazepate", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with trifluoperazine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with carisoprodol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "chloroxine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with nimodipine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with cilnidipine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Metipranolol.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Suvorexant is combined with Milnacipran.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with duloxetine.", "severity": 2}
{"drug1": "selegiline", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with sevoflurane.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with fluoxetine.", "severity": 2}
{"drug1": "glyburide", "drug2": "ethanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glyburide is combined with ethanol.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with felodipine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with physostigmine.", "severity": 2}
{"drug1": "ramipril", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with cyclophosphamide.", "severity": 2}
{"drug1": "reserpine", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Salsalate", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with hydrocortisone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halcinonide is combined with rivastigmine.", "severity": 2}
{"drug1": "captopril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with salicylamide.", "severity": 2}
{"drug1": "reserpine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with baclofen.", "severity": 2}
{"drug1": "scopolamine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with duloxetine.", "severity": 2}
{"drug1": "propofol", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with mecamylamine.", "severity": 2}
{"drug1": "propofol", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with trazodone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Agomelatine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "quinapril", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with NAPROXEN.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with levodopa.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with topiramate.", "severity": 2}
{"drug1": "quinapril", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with mefenamic acid.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with chlorprothixene.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with GUANFACINE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with paramethasone.", "severity": 2}
{"drug1": "Halazepam", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with DEZOCINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with clozapine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "etodolac", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Tixocortol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Levetiracetam.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Etidronic acid.", "severity": 2}
{"drug1": "propranolol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with isoxsuprine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with triamcinolone.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Ketobemidone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Loxoprofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with pirenzepine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with diltiazem.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Salsalate.", "severity": 2}
{"drug1": "clonidine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with isoxsuprine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Droxicam.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylpropanolamine is combined with nylidrin.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with propoxyphene.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with cyclophosphamide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with MOLINDONE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with dantrolene.", "severity": 2}
{"drug1": "buspirone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with scopolamine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nitrazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with spironolactone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "metaraminol", "drug2": "benzphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with benzphetamine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metaraminol is combined with ritodrine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with barnidipine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Apremilast.", "severity": 2}
{"drug1": "morphine", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with metolazone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with DEZOCINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Perospirone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with thiopental.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with ibuprofen.", "severity": 2}
{"drug1": "amisulpride", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with clonidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with AMILORIDE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Levetiracetam.", "severity": 2}
{"drug1": "ketamine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Desloratadine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Mephobarbital.", "severity": 2}
{"drug1": "ketamine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with mepivacaine.", "severity": 2}
{"drug1": "diazepam", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with propoxyphene.", "severity": 2}
{"drug1": "diazepam", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with dyclonine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with oxazepam.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Levetiracetam.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with paroxetine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl icosapentate is combined with aspirin.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aclidinium is combined with buprenorphine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with butamben.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with furosemide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with tizanidine.", "severity": 2}
{"drug1": "clemastine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Cariprazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Nebivolol.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "isradipine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with minoxidil.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "mirtazapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with mirtazapine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Ixabepilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Ixabepilone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with ketamine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "amantadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with amantadine.", "severity": 2}
{"drug1": "selegiline", "drug2": "HYDROCODONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with HYDROCODONE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with METAXALONE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with bromazepam.", "severity": 2}
{"drug1": "felbamate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with clomipramine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "tubocurarine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with tubocurarine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with zaltoprofen.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Olopatadine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with PAMABROM.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Cyamemazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with efavirenz.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with fenoldopam.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with nifedipine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with indapamide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with budesonide.", "severity": 2}
{"drug1": "ondansetron", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with GUANFACINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Pipotiazine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with cilazapril.", "severity": 2}
{"drug1": "midazolam", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with thiothixene.", "severity": 2}
{"drug1": "cerulenin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with flunarizine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with primidone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with Fluspirilene.", "severity": 2}
{"drug1": "prilocaine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with zotepine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with estrone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "losartan", "drug2": "Apremilast", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Apremilast.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with flurandrenolide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with nalbuphine.", "severity": 2}
{"drug1": "thiopental", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with efavirenz.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with flunitrazepam.", "severity": 2}
{"drug1": "phentolamine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with clidinium.", "severity": 2}
{"drug1": "felodipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with fludiazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with gabapentin.", "severity": 2}
{"drug1": "meperidine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Torasemide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Sodium phosphate monobasic", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Sodium phosphate monobasic.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Clevidipine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with efavirenz.", "severity": 2}
{"drug1": "suprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with flumethasone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Milnacipran.", "severity": 2}
{"drug1": "halothane", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with benazepril.", "severity": 2}
{"drug1": "halothane", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with amoxapine.", "severity": 2}
{"drug1": "halothane", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with nortriptyline.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with timolol.", "severity": 2}
{"drug1": "dapsone", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dapsone is combined with acetaminophen.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with doxepin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with triflupromazine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "hydroxyamphetamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenmetrazine is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "biperiden", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with Methadyl acetate.", "severity": 2}
{"drug1": "isradipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with dipyridamole.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Elbasvir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Elbasvir.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Alvimopan.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with Pipamperone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with Clobetasone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with meperidine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Agomelatine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with flunarizine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with salicylic acid.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with nitric oxide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Mephobarbital.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Desloratadine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Fospropofol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with bromazepam.", "severity": 2}
{"drug1": "enflurane", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with citalopram.", "severity": 2}
{"drug1": "baclofen", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with Pizotifen.", "severity": 2}
{"drug1": "benzocaine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with clemastine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with venlafaxine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "cocaine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with chlorprothixene.", "severity": 2}
{"drug1": "Artemether", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with nitrendipine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with brotizolam.", "severity": 2}
{"drug1": "Torasemide", "drug2": "gentamicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with gentamicin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Canrenoic acid.", "severity": 2}
{"drug1": "tolmetin", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with halcinonide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with ADAPALENE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with enalapril.", "severity": 2}
{"drug1": "tolmetin", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with difluprednate.", "severity": 2}
{"drug1": "Halazepam", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with mepivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with promethazine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with clonazepam.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with nadolol.", "severity": 2}
{"drug1": "epinastine", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with nimesulide.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fidaxomicin is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "oxazepam", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with oxymorphone.", "severity": 2}
{"drug1": "fusidic acid", "drug2": "Pitavastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fusidic acid is combined with Pitavastatin.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with topiramate.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with labetalol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Lurasidone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with Ticagrelor.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with AMILORIDE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Retigabine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with doxazosin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Oxetacaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with clotiazepam.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vildagliptin is combined with benazepril.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with papaverine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with duloxetine.", "severity": 2}
{"drug1": "clorazepate", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Empagliflozin.", "severity": 2}
{"drug1": "meperidine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with fluoxetine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "linezolid", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with haloperidol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with flunarizine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with chlorthalidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "oxaliplatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with oxaliplatin.", "severity": 2}
{"drug1": "linezolid", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with triflupromazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylprednisolone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "topiramate", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ketamine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with MOLINDONE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with baclofen.", "severity": 2}
{"drug1": "nicergoline", "drug2": "ranitidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with ranitidine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with olanzapine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Perospirone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with ESMOLOL.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with fludrocortisone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with DEZOCINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Pramocaine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with nifedipine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Mirabegron.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Levetiracetam.", "severity": 2}
{"drug1": "temazepam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Propoxycaine.", "severity": 2}
{"drug1": "clozapine", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with penbutolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with acemetacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "prochlorperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with prochlorperazine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with enalapril.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Bretylium.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with ALFENTANIL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with betamethasone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with nitrazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "teniposide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with teniposide.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Efonidipine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "lansoprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with lansoprazole.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with acetazolamide.", "severity": 2}
{"drug1": "valsartan", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with prazosin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with Rosuvastatin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with terbutaline.", "severity": 2}
{"drug1": "quazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with sulpiride.", "severity": 2}
{"drug1": "quazepam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with carisoprodol.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Risedronic acid is combined with fluvastatin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbinafine is combined with Lercanidipine.", "severity": 2}
{"drug1": "morphine", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Eszopiclone.", "severity": 2}
{"drug1": "morphine", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nisoldipine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with efavirenz.", "severity": 2}
{"drug1": "morphine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with loxapine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Clobetasone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Frovatriptan.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with nitroglycerin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with doxorubicin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with losartan.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with tizanidine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BISOPROLOL is combined with Eprosartan.", "severity": 2}
{"drug1": "enalapril", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with tolmetin.", "severity": 2}
{"drug1": "cetirizine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with maprotiline.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with Lormetazepam.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with HEROIN.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TROLAMINE SALICYLATE is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with tizanidine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pyridostigmine is combined with Carbamylcholine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with flurazepam.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with clomipramine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with dicyclomine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "tropicamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with tropicamide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "methadone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with dantrolene.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with Tasimelteon.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOBETASOL PROPIONATE is combined with NICORANDIL.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with antipyrine.", "severity": 2}
{"drug1": "methimazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methimazole is combined with atorvastatin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with CLONIXIN.", "severity": 2}
{"drug1": "sulindac", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with resveratrol.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nitric oxide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with clozapine.", "severity": 2}
{"drug1": "quazepam", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with maprotiline.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Riociguat.", "severity": 2}
{"drug1": "medrysone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with nalidixic acid.", "severity": 2}
{"drug1": "medrysone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with NICORANDIL.", "severity": 2}
{"drug1": "quazepam", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with mesoridazine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Milnacipran.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when orphenadrine is combined with sertraline.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with carvedilol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with losartan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with thioridazine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with Fospropofol.", "severity": 2}
{"drug1": "amifostine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "amifostine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with bumetanide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "TEMOPORFIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with TEMOPORFIN.", "severity": 2}
{"drug1": "nystatin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with felodipine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "oxazepam", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "loxapine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Flupentixol.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with reserpine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "procarbazine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procarbazine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "butalbital", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with tiagabine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with baclofen.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with diltiazem.", "severity": 2}
{"drug1": "butalbital", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with zonisamide.", "severity": 2}
{"drug1": "loxapine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Aceprometazine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with atenolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with furazolidone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with Halazepam.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with proparacaine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "brimonidine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with D-mannitol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Etidronic acid.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BUPRANOLOL is combined with Varenicline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Metipranolol.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Iloperidone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with fluoxetine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "linezolid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with linezolid.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mirtazapine is combined with sumatriptan.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with acemetacin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Fospropofol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Flupentixol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with nitroglycerin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Etidronic acid.", "severity": 2}
{"drug1": "atenolol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with metolazone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with prazosin.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Clevidipine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with enalapril.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Dehydroepiandrosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with chlorothiazide.", "severity": 2}
{"drug1": "morphine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Riociguat.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with scopolamine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aliskiren is combined with Empagliflozin.", "severity": 2}
{"drug1": "amifostine", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with ropinirole.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with eperisone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with VERAPAMIL.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with diflunisal.", "severity": 2}
{"drug1": "docetaxel", "drug2": "busulfan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with busulfan.", "severity": 2}
{"drug1": "docetaxel", "drug2": "hydroxyurea", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with hydroxyurea.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with selegiline.", "severity": 2}
{"drug1": "docetaxel", "drug2": "letrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with letrozole.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Fospropofol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with felbamate.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with CLONIXIN.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with nisoldipine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "acebutolol", "drug2": "nylidrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with nylidrin.", "severity": 2}
{"drug1": "codeine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with thiamylal.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Loxoprofen.", "severity": 2}
{"drug1": "risperidone", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with zopiclone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with triamcinolone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nefazodone is combined with desipramine.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with clozapine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with bepridil.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Fluspirilene.", "severity": 2}
{"drug1": "butorphanol", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with flunarizine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "floxuridine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with floxuridine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with atorvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with midazolam.", "severity": 2}
{"drug1": "irbesartan", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with benazepril.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Ropivacaine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with morphine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Articaine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with nifedipine.", "severity": 2}
{"drug1": "butalbital", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with topiramate.", "severity": 2}
{"drug1": "moclobemide", "drug2": "metaproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with metaproterenol.", "severity": 2}
{"drug1": "diflunisal", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with budesonide.", "severity": 2}
{"drug1": "suprofen", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with Agomelatine.", "severity": 2}
{"drug1": "methysergide", "drug2": "ritonavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ritonavir.", "severity": 2}
{"drug1": "methysergide", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with haloperidol.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with Rosuvastatin.", "severity": 2}
{"drug1": "lorazepam", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with amisulpride.", "severity": 2}
{"drug1": "isoflurane", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with diphenhydramine.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "pentobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with pentobarbital.", "severity": 2}
{"drug1": "fosinopril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with leflunomide.", "severity": 2}
{"drug1": "sertraline", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Lurasidone.", "severity": 2}
{"drug1": "ketamine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with chloral hydrate.", "severity": 2}
{"drug1": "aspirin", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "loteprednol", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loteprednol is combined with memantine.", "severity": 2}
{"drug1": "ketamine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with fludiazepam.", "severity": 2}
{"drug1": "THYMOL", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with nimesulide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with clomipramine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Eprosartan.", "severity": 2}
{"drug1": "clozapine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Tasimelteon.", "severity": 2}
{"drug1": "warfarin", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when warfarin is combined with Regorafenib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with zotepine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with MELPERONE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with METAXALONE.", "severity": 2}
{"drug1": "nylidrin", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nylidrin is combined with isoxsuprine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Estrone sulfate.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with nadolol.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with benzyl alcohol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Empagliflozin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with nitrendipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with cinnarizine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Iloperidone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with zonisamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with carprofen.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Drospirenone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Pipamperone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "DALFOPRISTIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with DALFOPRISTIN.", "severity": 2}
{"drug1": "reserpine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Halazepam.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Flibanserin.", "severity": 2}
{"drug1": "tiapride", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with fexofenadine.", "severity": 2}
{"drug1": "zotepine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with amitriptyline.", "severity": 2}
{"drug1": "zotepine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Tolcapone.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with citalopram.", "severity": 2}
{"drug1": "diclofenac", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with meclofenamic acid.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with methylprednisolone.", "severity": 2}
{"drug1": "estrone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with mefloquine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with dexamethasone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with minoxidil.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Cyamemazine.", "severity": 2}
{"drug1": "loxapine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with clonidine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with felbamate.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Spirapril", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with leflunomide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with meclizine.", "severity": 2}
{"drug1": "reserpine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with proparacaine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with NICORANDIL.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with carisoprodol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with lidocaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with clemastine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with bupropion.", "severity": 2}
{"drug1": "promethazine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with levodopa.", "severity": 2}
{"drug1": "tioconazole", "drug2": "xylometazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with xylometazoline.", "severity": 2}
{"drug1": "morniflumate", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with meclofenamic acid.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Normethadone.", "severity": 2}
{"drug1": "promethazine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Aripiprazole.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Articaine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with clenbuterol.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with enoxacin.", "severity": 2}
{"drug1": "quazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Normethadone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with nitroglycerin.", "severity": 2}
{"drug1": "clemastine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Flibanserin.", "severity": 2}
{"drug1": "loxapine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "nicardipine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with lisinopril.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with HEROIN.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with brotizolam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with nitroglycerin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with tranylcypromine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with prilocaine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with ethotoin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflorasone is combined with fleroxacin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with HEROIN.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Escitalopram.", "severity": 2}
{"drug1": "Etomidate", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with loratadine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Difenoxin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with midazolam.", "severity": 2}
{"drug1": "prazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with butamben.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "morphine", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with theobromine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with cetirizine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenytoin is combined with protriptyline.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "Masoprocol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with Masoprocol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with loteprednol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with difluprednate.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with tolazoline.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Levomilnacipran.", "severity": 2}
{"drug1": "pimozide", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with tiapride.", "severity": 2}
{"drug1": "pramipexole", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with hydralazine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with amcinonide.", "severity": 2}
{"drug1": "pergolide", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with betamethasone.", "severity": 2}
{"drug1": "Amrinone", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with Bretylium.", "severity": 2}
{"drug1": "oxycodone", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with vigabatrin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "ritodrine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with oxymetazoline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Regorafenib.", "severity": 2}
{"drug1": "oxycodone", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with benzocaine.", "severity": 2}
{"drug1": "propantheline", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propantheline is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with azelastine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Ezetimibe", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with Ezetimibe.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with quinapril.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Lurasidone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with bumetanide.", "severity": 2}
{"drug1": "propofol", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with amitriptyline.", "severity": 2}
{"drug1": "propofol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Tolcapone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with sertraline.", "severity": 2}
{"drug1": "propofol", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Nitroprusside.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Articaine.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Pizotifen.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with medrysone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Pizotifen.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with clonazepam.", "severity": 2}
{"drug1": "triprolidine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with promethazine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with captopril.", "severity": 2}
{"drug1": "clomipramine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with tretinoin.", "severity": 2}
{"drug1": "levodopa", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levodopa is combined with nefazodone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with dobutamine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Dapagliflozin.", "severity": 2}
{"drug1": "benztropine", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with pirenzepine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with methocarbamol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Levetiracetam.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Aceprometazine.", "severity": 2}
{"drug1": "quazepam", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with brotizolam.", "severity": 2}
{"drug1": "ethanol", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with sertraline.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with periciazine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Olopatadine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with dipyridamole.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with isoxsuprine.", "severity": 2}
{"drug1": "furosemide", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with penbutolol.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Fospropofol.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "simvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with simvastatin.", "severity": 2}
{"drug1": "sulconazole", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with nicardipine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with trandolapril.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with chlorzoxazone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Levocetirizine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with mecamylamine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Articaine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with Fluprednidene.", "severity": 2}
{"drug1": "procaine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Pipotiazine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with thiothixene.", "severity": 2}
{"drug1": "leflunomide", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIMENHYDRINATE is combined with clomipramine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with METAXALONE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with promethazine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with nalbuphine.", "severity": 2}
{"drug1": "indapamide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with nadolol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with CLONIXIN.", "severity": 2}
{"drug1": "enflurane", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Hexobarbital.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with Droxicam.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when niflumic acid is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Olmesartan.", "severity": 2}
{"drug1": "carprofen", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with flumethasone.", "severity": 2}
{"drug1": "prilocaine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with zonisamide.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Etomidate", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with cinnarizine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with ketoprofen.", "severity": 2}
{"drug1": "amobarbital", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with benzocaine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with sumatriptan.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with maprotiline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with vigabatrin.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with clenbuterol.", "severity": 2}
{"drug1": "losartan", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with fenbufen.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "epirizole", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with equilin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with desoximetasone.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when penbutolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with triamterene.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Bambuterol.", "severity": 2}
{"drug1": "loxapine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with butalbital.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with ambenonium.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with decamethonium.", "severity": 2}
{"drug1": "loxapine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "apomorphine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with chlorthalidone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with hydralazine.", "severity": 2}
{"drug1": "losartan", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with scopolamine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "brotizolam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with irbesartan.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with triflupromazine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with butorphanol.", "severity": 2}
{"drug1": "quazepam", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "benzocaine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Miltefosine is combined with Lercanidipine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with halcinonide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with meclizine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with nortriptyline.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with benazepril.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with amoxapine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "morphine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Ramelteon.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Ramelteon.", "severity": 2}
{"drug1": "meperidine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Olopatadine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Naftifine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Normethadone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "pimozide", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Ketobemidone.", "severity": 2}
{"drug1": "Butethal", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with methocarbamol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with cilazapril.", "severity": 2}
{"drug1": "Butethal", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with triprolidine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with pentazocine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Etomidate.", "severity": 2}
{"drug1": "tropicamide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with mecamylamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with bupivacaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Ropivacaine.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "SULFAMOXOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Etomidate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with flumethasone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with chlormezanone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with Metipranolol.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Tixocortol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with Tixocortol.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Perospirone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with Metipranolol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with fludrocortisone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with butamben.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Lercanidipine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with dibucaine.", "severity": 2}
{"drug1": "terazosin", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terazosin is combined with Aliskiren.", "severity": 2}
{"drug1": "isoflurane", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with metolazone.", "severity": 2}
{"drug1": "isoflurane", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with CARTEOLOL.", "severity": 2}
{"drug1": "benzocaine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with meclizine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with proparacaine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Halobetasol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Halobetasol.", "severity": 2}
{"drug1": "estazolam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with fexofenadine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Halazepam.", "severity": 2}
{"drug1": "clorazepate", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with halothane.", "severity": 2}
{"drug1": "clorazepate", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with thiamylal.", "severity": 2}
{"drug1": "clorazepate", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with desipramine.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "orphenadrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with orphenadrine.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with cilnidipine.", "severity": 2}
{"drug1": "Artemether", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with lidocaine.", "severity": 2}
{"drug1": "scopolamine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with paroxetine.", "severity": 2}
{"drug1": "selegiline", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with lithium ion.", "severity": 2}
{"drug1": "triamterene", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "doxepin", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Difenoxin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when norepinephrine is combined with isoproterenol.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with mecamylamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with spironolactone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with mecamylamine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with azelastine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Pipamperone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with dibucaine.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Levocetirizine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with flunarizine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Lormetazepam.", "severity": 2}
{"drug1": "meperidine", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with theobromine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "pargyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with pargyline.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with salicylamide.", "severity": 2}
{"drug1": "Metixene", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with morphine.", "severity": 2}
{"drug1": "zotepine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with desipramine.", "severity": 2}
{"drug1": "temazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with triprolidine.", "severity": 2}
{"drug1": "midazolam", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with nitrous oxide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "estramustine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with estramustine.", "severity": 2}
{"drug1": "temazepam", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with methocarbamol.", "severity": 2}
{"drug1": "doxepin", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with Levalbuterol.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Normethadone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with decamethonium.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apraclonidine is combined with felodipine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "gentamicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with gentamicin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "tropicamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with tropicamide.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with procarbazine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "dicyclomine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with dicyclomine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Fospropofol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "indomethacin", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "ketamine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with protriptyline.", "severity": 2}
{"drug1": "ketamine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with cetirizine.", "severity": 2}
{"drug1": "midazolam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with sevoflurane.", "severity": 2}
{"drug1": "clemastine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with tizanidine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with chlorprothixene.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Calcipotriol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with promethazine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with clonazepam.", "severity": 2}
{"drug1": "codeine", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with triamterene.", "severity": 2}
{"drug1": "Halazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with butamben.", "severity": 2}
{"drug1": "isradipine", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with propranolol.", "severity": 2}
{"drug1": "epirizole", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with hydrocortisone.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with triamterene.", "severity": 2}
{"drug1": "isradipine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with clonidine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETOFENAMATE is combined with epirizole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with proparacaine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with AMILORIDE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with ethosuximide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "methimazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with methimazole.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with mefenamic acid.", "severity": 2}
{"drug1": "pergolide", "drug2": "sulfinpyrazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with oxyphenonium.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with NAPROXEN.", "severity": 2}
{"drug1": "alprenolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprenolol is combined with acetylcholine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with thiopental.", "severity": 2}
{"drug1": "Limaprost", "drug2": "EDOXABAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with EDOXABAN.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Lornoxicam.", "severity": 2}
{"drug1": "temazepam", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with nitrazepam.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with nifedipine.", "severity": 2}
{"drug1": "pergolide", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with clofazimine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with physostigmine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Thioproperazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with thiothixene.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Pipotiazine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "butabarbital", "drug2": "pentobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with pentobarbital.", "severity": 2}
{"drug1": "sulpiride", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with tizanidine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Levocetirizine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with triamterene.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when daunorubicin is combined with clozapine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Eletriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Eletriptan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with citalopram.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "PHENPROCOUMON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Benidipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Benidipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with antipyrine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "methyltestosterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with methyltestosterone.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fingolimod is combined with leflunomide.", "severity": 2}
{"drug1": "Perospirone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with fexofenadine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with METAXALONE.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Levomepromazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with METAXALONE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with isradipine.", "severity": 2}
{"drug1": "midazolam", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with flurazepam.", "severity": 2}
{"drug1": "midazolam", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with tizanidine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Olmesartan.", "severity": 2}
{"drug1": "meclizine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with Ramelteon.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Alvimopan.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butoconazole is combined with nimodipine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with sotalol.", "severity": 2}
{"drug1": "azelastine", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with alclofenac.", "severity": 2}
{"drug1": "doxazosin", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with methazolamide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with Eplerenone.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vorapaxar is combined with Apixaban.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with ethotoin.", "severity": 2}
{"drug1": "ramipril", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with ibuprofen.", "severity": 2}
{"drug1": "diazepam", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with Ketobemidone.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Pipotiazine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Atracurium besylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with Atracurium besylate.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with Etoricoxib.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Ramelteon.", "severity": 2}
{"drug1": "captopril", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with ketoprofen.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with zonisamide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with tiagabine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with equilin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "cisapride", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cisapride is combined with atorvastatin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Varenicline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with flunitrazepam.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Asenapine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with NICORANDIL.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with Lormetazepam.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Olsalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Olsalazine.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Tapentadol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with mesalamine.", "severity": 2}
{"drug1": "codeine", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "clemastine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with ethosuximide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "methadone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with chlorprothixene.", "severity": 2}
{"drug1": "etodolac", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with ibuprofen.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when xylometazoline is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with PERHEXILINE.", "severity": 2}
{"drug1": "methadone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with metoclopramide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with thiopental.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with paroxetine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with methocarbamol.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with Ciclesonide.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluvoxamine is combined with triprolidine.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with butalbital.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Pizotifen.", "severity": 2}
{"drug1": "codeine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with MELPERONE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with haloperidol.", "severity": 2}
{"drug1": "amisulpride", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with GUANFACINE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Fluspirilene.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with triflupromazine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "rapamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with rapamycin.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Etidocaine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with sulfasalazine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with perphenazine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Flibanserin.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "mebendazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with mebendazole.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Pemetrexed", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Pemetrexed.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with lithium ion.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with resveratrol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with oxycodone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nifedipine is combined with captopril.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Echothiophate is combined with methacholine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with haloperidol.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with methazolamide.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "AMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tianeptine is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "suprofen", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Droxicam.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with Torasemide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with flunitrazepam.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with theobromine.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with methscopolamine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with chlormezanone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Phenelzine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with Phenelzine.", "severity": 2}
{"drug1": "midodrine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midodrine is combined with PROCATEROL.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with niflumic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with sulpiride.", "severity": 2}
{"drug1": "linezolid", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with tiapride.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Escitalopram.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Lurasidone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with chlorthalidone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "buspirone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with cetirizine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with dipivefrin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "butorphanol", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with METAXALONE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Carbamylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propranolol is combined with Carbamylcholine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Pizotifen.", "severity": 2}
{"drug1": "thiothixene", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with Olopatadine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with loratadine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with amcinonide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "diflunisal", "drug2": "ketoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with ketoprofen.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "PAMABROM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with PAMABROM.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with salicylic acid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with Sacubitril.", "severity": 2}
{"drug1": "buspirone", "drug2": "naratriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with naratriptan.", "severity": 2}
{"drug1": "buspirone", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with rizatriptan.", "severity": 2}
{"drug1": "buspirone", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with fexofenadine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with meclofenamic acid.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with fosinopril.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with tizanidine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Pipamperone.", "severity": 2}
{"drug1": "spiramycin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spiramycin is combined with atorvastatin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Tramadol", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with dyclonine.", "severity": 2}
{"drug1": "Trospium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with buprenorphine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with indapamide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Oxetacaine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lofexidine is combined with nitroglycerin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluprednidene is combined with Gemifloxacin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with estazolam.", "severity": 2}
{"drug1": "halothane", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Retigabine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Clevidipine.", "severity": 2}
{"drug1": "midazolam", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with procaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with tranylcypromine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with oxycodone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with risperidone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with cetirizine.", "severity": 2}
{"drug1": "enflurane", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with sulpiride.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with MELPERONE.", "severity": 2}
{"drug1": "azelastine", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with Fluprednidene.", "severity": 2}
{"drug1": "enflurane", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with carisoprodol.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with topiramate.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with mepivacaine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Desloratadine.", "severity": 2}
{"drug1": "prazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with desipramine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with mecamylamine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with topiramate.", "severity": 2}
{"drug1": "trazodone", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with tetracaine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with irbesartan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with hydralazine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with alclofenac.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with PROCATEROL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with rasagiline.", "severity": 2}
{"drug1": "desipramine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with dantrolene.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "rizatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with rizatriptan.", "severity": 2}
{"drug1": "alprazolam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with efavirenz.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "isoniazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with isoniazid.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with mianserin.", "severity": 2}
{"drug1": "cocaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Agomelatine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with etizolam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with methylprednisolone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clorazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with clorazepate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Milnacipran.", "severity": 2}
{"drug1": "cocaine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with Melatonin.", "severity": 2}
{"drug1": "cocaine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with clonazepam.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Lurasidone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with zotepine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Zoledronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with Zoledronic acid.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with fluocinonide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with levodopa.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with eperisone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Etidocaine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "bepridil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with bepridil.", "severity": 2}
{"drug1": "gabapentin", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with clomipramine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with reserpine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Tapentadol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with metoprolol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Tramadol", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with chlorpheniramine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with papaverine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "physostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with physostigmine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dexamethasone is combined with rivastigmine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with flurandrenolide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Clodronic Acid.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with ondansetron.", "severity": 2}
{"drug1": "levorphanol", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with cocaine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with tiagabine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "topiramate", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with felbamate.", "severity": 2}
{"drug1": "loratadine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Halazepam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with chlorprothixene.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with isoxsuprine.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with Hexobarbital.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with thalidomide.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SOMATOSTATIN is combined with amobarbital.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with azelastine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with azelastine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "cilostazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with cilostazol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Retigabine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Milnacipran.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Normethadone.", "severity": 2}
{"drug1": "methysergide", "drug2": "rivastigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with rivastigmine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with clonazepam.", "severity": 2}
{"drug1": "tolmetin", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with flumethasone.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with oxycodone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Lormetazepam.", "severity": 2}
{"drug1": "benzocaine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclosporin A is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with aspirin.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ephedrine is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with sulindac.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with methacholine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Fesoterodine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Metipranolol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with minoxidil.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "clomiphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with clomiphene.", "severity": 2}
{"drug1": "butamben", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Difenoxin.", "severity": 2}
{"drug1": "carprofen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with difluprednate.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with zotepine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with MELPERONE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Clobetasone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with floctafenine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with Telmisartan.", "severity": 2}
{"drug1": "codeine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with apraclonidine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "sparfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with sparfloxacin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Lornoxicam.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Naftifine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Naftifine.", "severity": 2}
{"drug1": "buspirone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with clidinium.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with cilazapril.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with tretinoin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Estrone sulfate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with Estrone sulfate.", "severity": 2}
{"drug1": "trandolapril", "drug2": "BISOPROLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "ethinyl estradiol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "Spirapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Linagliptin is combined with Spirapril.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "morphine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mesalamine", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with formestane.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Fluticasone furoate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesalamine is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulconazole is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clotrimazole is combined with Lacidipine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with Amrinone.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Ramelteon.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with dipyridamole.", "severity": 2}
{"drug1": "sertraline", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with Levomilnacipran.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with trifluoperazine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with diflorasone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Ecabet", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Ecabet.", "severity": 2}
{"drug1": "thiothixene", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with tetracaine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Aliskiren.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Ramelteon.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "quazepam", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with diflorasone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with Enalaprilat.", "severity": 2}
{"drug1": "medrysone", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with Demecarium.", "severity": 2}
{"drug1": "sulpiride", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with proparacaine.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "furosemide", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with terazosin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with Levomilnacipran.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with difluprednate.", "severity": 2}
{"drug1": "morphine", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with zonisamide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with nitrous oxide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Ketobemidone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with triamterene.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with carisoprodol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Boceprevir is combined with toremifene.", "severity": 2}
{"drug1": "aspirin", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with fludrocortisone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Aliskiren.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Tapentadol.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Boceprevir is combined with cyclophosphamide.", "severity": 2}
{"drug1": "isradipine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with tizanidine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Isoflurophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Isoflurophate.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with galanthamine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Canagliflozin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Efonidipine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with atorvastatin.", "severity": 2}
{"drug1": "triamterene", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Lurasidone.", "severity": 2}
{"drug1": "promazine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Flupentixol.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Cis-mdp.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with leflunomide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "thioguanine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with thioguanine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Pomalidomide.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentolinium is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with primidone.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with levorphanol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with alclofenac.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with phenytoin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Lanreotide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Lanreotide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with amoxapine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ambroxol is combined with atorvastatin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with methyclothiazide.", "severity": 2}
{"drug1": "amisulpride", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with nortriptyline.", "severity": 2}
{"drug1": "halothane", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with METAXALONE.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "reserpine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with levorphanol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with felbamate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "reserpine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with perphenazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "methotrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with methotrexate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with scopolamine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Pomalidomide.", "severity": 2}
{"drug1": "formestane", "drug2": "donepezil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with donepezil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with D-mannitol.", "severity": 2}
{"drug1": "diflunisal", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "docetaxel", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with anastrozole.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tofacitinib is combined with leflunomide.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Levomilnacipran.", "severity": 2}
{"drug1": "rapamycin", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Pomalidomide.", "severity": 2}
{"drug1": "promethazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Pizotifen.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with chlormezanone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with CYCLIZINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with triflupromazine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with gabapentin.", "severity": 2}
{"drug1": "methysergide", "drug2": "caffeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with caffeine.", "severity": 2}
{"drug1": "methysergide", "drug2": "sildenafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with sildenafil.", "severity": 2}
{"drug1": "methysergide", "drug2": "azithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with azithromycin.", "severity": 2}
{"drug1": "methysergide", "drug2": "ticlopidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with ticlopidine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with chlorpheniramine.", "severity": 2}
{"drug1": "pergolide", "drug2": "Ticagrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with Ticagrelor.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Sacubitril.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Sacubitril.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with Pipamperone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Etomidate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with Escitalopram.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with Ropivacaine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with amisulpride.", "severity": 2}
{"drug1": "Melatonin", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with clemastine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with furosemide.", "severity": 2}
{"drug1": "Melatonin", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with venlafaxine.", "severity": 2}
{"drug1": "pergolide", "drug2": "tofisopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with tofisopam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Nitroprusside.", "severity": 2}
{"drug1": "cerulenin", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with Tolcapone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "aspirin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with aspirin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Dapagliflozin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PSEUDOEPHEDRINE is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with deslanoside.", "severity": 2}
{"drug1": "procaine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Salsalate", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with resveratrol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with halothane.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with metoclopramide.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Ramelteon.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with acetaminophen.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nicardipine.", "severity": 2}
{"drug1": "zotepine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with Lormetazepam.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with efavirenz.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metronidazole is combined with Carbocisteine.", "severity": 2}
{"drug1": "prazepam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with flunarizine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with Fluspirilene.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Dapagliflozin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with quetiapine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with MELPERONE.", "severity": 2}
{"drug1": "terconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with ethotoin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with valsartan.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with flumethasone.", "severity": 2}
{"drug1": "loxapine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "loxapine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with flunitrazepam.", "severity": 2}
{"drug1": "isoflurane", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with propoxyphene.", "severity": 2}
{"drug1": "isoflurane", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with dyclonine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with Levobupivacaine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Pipamperone.", "severity": 2}
{"drug1": "cetirizine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Pramocaine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with Propoxycaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with Nebivolol.", "severity": 2}
{"drug1": "levorphanol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with AMILORIDE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with ethosuximide.", "severity": 2}
{"drug1": "methysergide", "drug2": "clotiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clotiazepam.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Vorinostat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Vorinostat.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with Torasemide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Perospirone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with thiopental.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with minoxidil.", "severity": 2}
{"drug1": "cilazapril", "drug2": "zaltoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with zaltoprofen.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Aceclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Aceclofenac.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with terazosin.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with meperidine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Clobetasone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with trazodone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with apraclonidine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Telmisartan.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Varenicline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when galanthamine is combined with Varenicline.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "procarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with procarbazine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with propoxyphene.", "severity": 2}
{"drug1": "Butethal", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with desipramine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "phenoxybenzamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "losartan", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with fenoprofen.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with estazolam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Tasimelteon.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Iloperidone.", "severity": 2}
{"drug1": "losartan", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Propacetamol.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ANISOTROPINE METHYLBROMIDE is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with chlorprothixene.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Fosphenytoin.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with dantrolene.", "severity": 2}
{"drug1": "Torasemide", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with quetiapine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with nefazodone.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with doxepin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with sulpiride.", "severity": 2}
{"drug1": "floctafenine", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with flurandrenolide.", "severity": 2}
{"drug1": "Etomidate", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with carisoprodol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tixocortol is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with primidone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Etidronic acid.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with isradipine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with maprotiline.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with labetalol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with homoharringtonine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with mesoridazine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE DINITRATE is combined with GUANFACINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PSEUDOEPHEDRINE is combined with selegiline.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with butorphanol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with doxepin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Hexobarbital.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with etizolam.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with amobarbital.", "severity": 2}
{"drug1": "triazolam", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with thiamylal.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nefazodone.", "severity": 2}
{"drug1": "triazolam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with desipramine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with vigabatrin.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with clonazepam.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with promethazine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with benzocaine.", "severity": 2}
{"drug1": "proparacaine", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with ethosuximide.", "severity": 2}
{"drug1": "ramipril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "triamterene", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with AMILORIDE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with doxazosin.", "severity": 2}
{"drug1": "triamterene", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with doxazosin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with ethosuximide.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with flunarizine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with fenbufen.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with thiopental.", "severity": 2}
{"drug1": "triamterene", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with labetalol.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with Tramadol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with desipramine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Imatinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Imatinib.", "severity": 2}
{"drug1": "trandolapril", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with chlorothiazide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with haloperidol.", "severity": 2}
{"drug1": "propofol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with methocarbamol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with tolmetin.", "severity": 2}
{"drug1": "propofol", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with spironolactone.", "severity": 2}
{"drug1": "propofol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with triprolidine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with Propacetamol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with butamben.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with nitrazepam.", "severity": 2}
{"drug1": "meperidine", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with trifluoperazine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with zonisamide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with carvedilol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with MOLINDONE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with lisinopril.", "severity": 2}
{"drug1": "ethanol", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with fluvoxamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with isocarboxazid.", "severity": 2}
{"drug1": "HEROIN", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with clomipramine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with tiagabine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with ethotoin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with prilocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with isoflurane.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with tranylcypromine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with Paliperidone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Fosphenytoin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Aceprometazine.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOLINDONE is combined with tetracaine.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Levocetirizine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with MOLINDONE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "codeine", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with brotizolam.", "severity": 2}
{"drug1": "codeine", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with Sacubitril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Cariprazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Cariprazine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with Empagliflozin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Eplerenone.", "severity": 2}
{"drug1": "triazolam", "drug2": "lidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with lidocaine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with fenbufen.", "severity": 2}
{"drug1": "Etomidate", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with dyclonine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with mepivacaine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with GUANFACINE.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with Pizotifen.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Tapentadol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Articaine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with flunarizine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desoximetasone is combined with mefloquine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with Clobetasone.", "severity": 2}
{"drug1": "prednisone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with memantine.", "severity": 2}
{"drug1": "timolol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with methazolamide.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Etidronic acid.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with trimipramine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with Desloratadine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with fluocinonide.", "severity": 2}
{"drug1": "reserpine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with nalbuphine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Clodronic Acid.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with periciazine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with diphenhydramine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "pargyline", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with reserpine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "chlorthalidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with chlorthalidone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "formoterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with formoterol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Ramelteon.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aprepitant is combined with atorvastatin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "thalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with thalidomide.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluoxetine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with meclofenamic acid.", "severity": 2}
{"drug1": "butabarbital", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with desipramine.", "severity": 2}
{"drug1": "amifostine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with sevoflurane.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with oxymorphone.", "severity": 2}
{"drug1": "nystatin", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Risedronic acid.", "severity": 2}
{"drug1": "amiodarone", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with oxycodone.", "severity": 2}
{"drug1": "Metixene", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with SUFENTANIL.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with SERTINDOLE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with fosinopril.", "severity": 2}
{"drug1": "Normethadone", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with maprotiline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "pimozide", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with Eplerenone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with methazolamide.", "severity": 2}
{"drug1": "trazodone", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with periciazine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "irbesartan", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with hydralazine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Tramadol", "drug2": "reserpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with reserpine.", "severity": 2}
{"drug1": "benazepril", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with labetalol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Tasimelteon.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with tiapride.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dabigatran etexilate is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "Articaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with butamben.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with Aliskiren.", "severity": 2}
{"drug1": "meprobamate", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with risperidone.", "severity": 2}
{"drug1": "sotalol", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with losartan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with terazosin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with paroxetine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with Ciclesonide.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with felodipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with enflurane.", "severity": 2}
{"drug1": "midazolam", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with MOLINDONE.", "severity": 2}
{"drug1": "midazolam", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with Fluspirilene.", "severity": 2}
{"drug1": "benazepril", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with doxazosin.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pentyl nitrite is combined with Empagliflozin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Perospirone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with mesoridazine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with Ropivacaine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with chloral hydrate.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with sulfasalazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with fludiazepam.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with timolol.", "severity": 2}
{"drug1": "ranitidine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ranitidine is combined with atorvastatin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with dantrolene.", "severity": 2}
{"drug1": "sotalol", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with enalapril.", "severity": 2}
{"drug1": "paroxetine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with loxapine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethosuximide is combined with Ramelteon.", "severity": 2}
{"drug1": "amisulpride", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with clemastine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "trazodone", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Desloratadine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with spironolactone.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with edrophonium.", "severity": 2}
{"drug1": "prilocaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with HEROIN.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "meperidine", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with nitrazepam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with homoharringtonine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with butorphanol.", "severity": 2}
{"drug1": "benzocaine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with HEROIN.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with D-mannitol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with METAXALONE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Tolcapone.", "severity": 2}
{"drug1": "dibucaine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with amitriptyline.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with butorphanol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Ixabepilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with Ixabepilone.", "severity": 2}
{"drug1": "clorazepate", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with thioridazine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fesoterodine is combined with nalbuphine.", "severity": 2}
{"drug1": "bifonazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with eperisone.", "severity": 2}
{"drug1": "estrone", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estrone is combined with NICORANDIL.", "severity": 2}
{"drug1": "clozapine", "drug2": "pentazocine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with pentazocine.", "severity": 2}
{"drug1": "baclofen", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with clidinium.", "severity": 2}
{"drug1": "valsartan", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with nisoldipine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with propoxyphene.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with dyclonine.", "severity": 2}
{"drug1": "loxapine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with tiagabine.", "severity": 2}
{"drug1": "clonidine", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "enflurane", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with efavirenz.", "severity": 2}
{"drug1": "ketorolac", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with salicylic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Ramelteon.", "severity": 2}
{"drug1": "Icatibant", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with homoharringtonine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "Entecavir", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with Entecavir.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with dantrolene.", "severity": 2}
{"drug1": "pimozide", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Fluspirilene.", "severity": 2}
{"drug1": "benazepril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with Temsirolimus.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Flibanserin.", "severity": 2}
{"drug1": "epinephrine", "drug2": "MEPHENTERMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with flunarizine.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with irbesartan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with felodipine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Propiverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Propiverine.", "severity": 2}
{"drug1": "clozapine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dasatinib is combined with atorvastatin.", "severity": 2}
{"drug1": "clozapine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with terazosin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with irbesartan.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with felodipine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "tretinoin", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tretinoin is combined with betaxolol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with alclometasone.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with triamterene.", "severity": 2}
{"drug1": "zaleplon", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with amoxapine.", "severity": 2}
{"drug1": "enflurane", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with nortriptyline.", "severity": 2}
{"drug1": "morphine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with levorphanol.", "severity": 2}
{"drug1": "codeine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with ketamine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with leflunomide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with clidinium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with fenoprofen.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Milnacipran.", "severity": 2}
{"drug1": "pentazocine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with meclizine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with risperidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenobarbital is combined with dyclonine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Levalbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Levalbuterol.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with proparacaine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with chloroquine.", "severity": 2}
{"drug1": "dibucaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with Normethadone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Ramelteon.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Acitretin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when demeclocycline is combined with Acitretin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with imipramine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with meclizine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with SERTINDOLE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "allopurinol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with allopurinol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with ADAPALENE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with dantrolene.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with Canrenoic acid.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with flurbiprofen.", "severity": 2}
{"drug1": "etodolac", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "budesonide", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when budesonide is combined with mefloquine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BECLOMETHASONE DIPROPIONATE is combined with pyridostigmine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with cinnarizine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with Flupentixol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Articaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with DEZOCINE.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with captopril.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CICLOPIROX is combined with Pregabalin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with halothane.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with clozapine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "temazepam", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with thioridazine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Salsalate.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with NITROUS ACID.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with triprolidine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with paroxetine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with chlorothiazide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with quinapril.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with bumetanide.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with phenytoin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with Olopatadine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with clozapine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with etodolac.", "severity": 2}
{"drug1": "morniflumate", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with leflunomide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eplerenone is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "pimozide", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with loratadine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with alclometasone.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Halazepam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with loratadine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ketamine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "TROLEANDOMYCIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with propoxyphene.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with dyclonine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "PERHEXILINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with PERHEXILINE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with ondansetron.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with primidone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with losartan.", "severity": 2}
{"drug1": "epirizole", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with methylprednisolone.", "severity": 2}
{"drug1": "methadone", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with spironolactone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with triflupromazine.", "severity": 2}
{"drug1": "methadone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with methocarbamol.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with dichlorphenamide.", "severity": 2}
{"drug1": "methyldopa", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with lithium ion.", "severity": 2}
{"drug1": "pergolide", "drug2": "ROLITETRACYCLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with mepivacaine.", "severity": 2}
{"drug1": "captopril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Propacetamol.", "severity": 2}
{"drug1": "morphine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with butamben.", "severity": 2}
{"drug1": "butalbital", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with fexofenadine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Ramelteon.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Fencamfamin.", "severity": 2}
{"drug1": "pimozide", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Normethadone.", "severity": 2}
{"drug1": "Etomidate", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Limaprost", "drug2": "ILOPROST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with ILOPROST.", "severity": 2}
{"drug1": "edrophonium", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when edrophonium is combined with pilocarpine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with topiramate.", "severity": 2}
{"drug1": "Propiverine", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with SUFENTANIL.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with Risedronic acid.", "severity": 2}
{"drug1": "cerulenin", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with cinnarizine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with atorvastatin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with zonisamide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "mequitazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with mequitazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Pomalidomide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with ethchlorvynol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with Clevidipine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with baclofen.", "severity": 2}
{"drug1": "terconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Ramelteon.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with Difenoxin.", "severity": 2}
{"drug1": "captopril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with Teriflunomide.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "trimipramine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimipramine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "oxycodone", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with cyclothiazide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with tiapride.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "temozolomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with temozolomide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "dacarbazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with dacarbazine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "5-Aminolevulinic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with 5-Aminolevulinic acid.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with nitrendipine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Butethal.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with brotizolam.", "severity": 2}
{"drug1": "thiopental", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzoic acid is combined with isradipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "bifonazole", "drug2": "isradipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bifonazole is combined with isradipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olopatadine is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with medrysone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ketobemidone is combined with meclizine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Fluspirilene.", "severity": 2}
{"drug1": "baclofen", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIPECURONIUM is combined with Mirabegron.", "severity": 2}
{"drug1": "butenafine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butenafine is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "NITROUS ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrofurantoin is combined with NITROUS ACID.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with polythiazide.", "severity": 2}
{"drug1": "Apremilast", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when EFINACONAZOLE is combined with flunarizine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with prilocaine.", "severity": 2}
{"drug1": "nadolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with nicotine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nadolol is combined with Cevimeline.", "severity": 2}
{"drug1": "butorphanol", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with ethotoin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with mepivacaine.", "severity": 2}
{"drug1": "codeine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Difenoxin.", "severity": 2}
{"drug1": "codeine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with HEROIN.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with DEZOCINE.", "severity": 2}
{"drug1": "buspirone", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with pimozide.", "severity": 2}
{"drug1": "tirofiban", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tirofiban is combined with diflunisal.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "alclometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with alclometasone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Azelnidipine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Efonidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentamidine is combined with Efonidipine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with carisoprodol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with Tolcapone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "aspirin", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with spironolactone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with methocarbamol.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Lornoxicam.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with ritodrine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with lithium ion.", "severity": 2}
{"drug1": "Apremilast", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with prednisone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with isoetharine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Iloperidone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buprenorphine is combined with spironolactone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Levetiracetam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Amrubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Amrubicin.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Pramocaine.", "severity": 2}
{"drug1": "enflurane", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with levodopa.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with perphenazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with meclofenamic acid.", "severity": 2}
{"drug1": "enflurane", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with chlorprothixene.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "tetracaine", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with topiramate.", "severity": 2}
{"drug1": "diazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with enflurane.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Metipranolol.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with Mometasone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with cyclothiazide.", "severity": 2}
{"drug1": "thiopental", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Milnacipran.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with acemetacin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with nimodipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with butamben.", "severity": 2}
{"drug1": "biperiden", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with codeine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with DEZOCINE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with diflorasone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with isocarboxazid.", "severity": 2}
{"drug1": "selegiline", "drug2": "mianserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with mianserin.", "severity": 2}
{"drug1": "buspirone", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with levorphanol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with methazolamide.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with dantrolene.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Levetiracetam.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Eplerenone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Olmesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Olmesartan.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with memantine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with Cis-mdp.", "severity": 2}
{"drug1": "alprazolam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with duloxetine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with fluoxetine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "loratadine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with clonidine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Fencamfamin.", "severity": 2}
{"drug1": "meperidine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pirlindole is combined with Vilanterol.", "severity": 2}
{"drug1": "felodipine", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felodipine is combined with dichlorphenamide.", "severity": 2}
{"drug1": "ethotoin", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with clonazepam.", "severity": 2}
{"drug1": "ethotoin", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with promethazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Potassium citrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Potassium citrate.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with diltiazem.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Milnacipran.", "severity": 2}
{"drug1": "furazolidone", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with brimonidine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with Olopatadine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with manidipine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Toloxatone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Lacidipine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with promethazine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Azelnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Azelnidipine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with Benidipine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "cilnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloprogin is combined with cilnidipine.", "severity": 2}
{"drug1": "lorazepam", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with trifluoperazine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Milnacipran.", "severity": 2}
{"drug1": "temazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with clidinium.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "Emtricitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ganciclovir is combined with Emtricitabine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxiconazole is combined with diltiazem.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "miconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with nimesulide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Lormetazepam.", "severity": 2}
{"drug1": "diflunisal", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with niflumic acid.", "severity": 2}
{"drug1": "Spirapril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with fenoprofen.", "severity": 2}
{"drug1": "propofol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ropinirole", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with D-mannitol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "doxepin", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with terbutaline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "celiprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with celiprolol.", "severity": 2}
{"drug1": "amifostine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with sotalol.", "severity": 2}
{"drug1": "amifostine", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with Nabilone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ibuprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with ibuprofen.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with MOLINDONE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Butethal.", "severity": 2}
{"drug1": "pargyline", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with hydralazine.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "Cangrelor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with Cangrelor.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Sacubitril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with Sacubitril.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with moclobemide.", "severity": 2}
{"drug1": "scopolamine", "drug2": "STIRIPENTOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "mifepristone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with mifepristone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "ritodrine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ritodrine is combined with terbutaline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with dipivefrin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with Nitroprusside.", "severity": 2}
{"drug1": "trazodone", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with Milnacipran.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "ambenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when RIMEXOLONE is combined with ambenonium.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with desipramine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with butamben.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "chloramphenicol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with chloramphenicol.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with cilazapril.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Normethadone.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with KETAZOLAM.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "trandolapril", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with tolfenamic acid.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "acetaminophen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with acetaminophen.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with rasagiline.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with paramethasone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with trazodone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with vigabatrin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "formestane", "drug2": "fleroxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when formestane is combined with fleroxacin.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymetazoline is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with nicardipine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Ethylmorphine.", "severity": 2}
{"drug1": "atenolol", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with methazolamide.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with sevoflurane.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with clenbuterol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Milnacipran.", "severity": 2}
{"drug1": "pentosan polysulfate", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentosan polysulfate is combined with sevoflurane.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with efavirenz.", "severity": 2}
{"drug1": "thalidomide", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with cilazapril.", "severity": 2}
{"drug1": "papaverine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with cilazapril.", "severity": 2}
{"drug1": "methysergide", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Tadalafil.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Levetiracetam.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Rosuvastatin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "methysergide", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with diazepam.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with DEZOCINE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with fluvastatin.", "severity": 2}
{"drug1": "teniposide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when teniposide is combined with atorvastatin.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Oxetacaine.", "severity": 2}
{"drug1": "METAXALONE", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METAXALONE is combined with Difenoxin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with clonidine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with GUANFACINE.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Milnacipran.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "TRIMETHAPHAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with TRIMETHAPHAN.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with Pomalidomide.", "severity": 2}
{"drug1": "clozapine", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nadolol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Toloxatone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Toloxatone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Pirlindole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pirlindole.", "severity": 2}
{"drug1": "Perospirone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with efavirenz.", "severity": 2}
{"drug1": "quazepam", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Remoxipride.", "severity": 2}
{"drug1": "thiopental", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with butamben.", "severity": 2}
{"drug1": "quazepam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mometasone is combined with Trovafloxacin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trimeprazine is combined with Milnacipran.", "severity": 2}
{"drug1": "nimodipine", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with irbesartan.", "severity": 2}
{"drug1": "clonidine", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Clevidipine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with carisoprodol.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Fospropofol.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with paramethasone.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "nimodipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with felodipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nystatin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with barnidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with tiapride.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with clidinium.", "severity": 2}
{"drug1": "pramipexole", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with minoxidil.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with trimipramine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with venlafaxine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "hydroflumethiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with nitroglycerin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with Eplerenone.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acetazolamide is combined with atorvastatin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with methazolamide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with Deferasirox.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with metoclopramide.", "severity": 2}
{"drug1": "tropicamide", "drug2": "oxyphenonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with oxyphenonium.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Iloperidone.", "severity": 2}
{"drug1": "Butethal", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with tizanidine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with tolmetin.", "severity": 2}
{"drug1": "meprobamate", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with diazepam.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with clonidine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "SERATRODAST", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with SERATRODAST.", "severity": 2}
{"drug1": "lorazepam", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with methocarbamol.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with methylphenidate.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Levomilnacipran.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with benazepril.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "thalidomide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with HEROIN.", "severity": 2}
{"drug1": "lorazepam", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with sulpiride.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Metixene.", "severity": 2}
{"drug1": "codeine", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with perphenazine.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "meprobamate", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with thiothixene.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Levomilnacipran.", "severity": 2}
{"drug1": "carmustine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carmustine is combined with clozapine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propacetamol is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "pargyline", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with isoproterenol.", "severity": 2}
{"drug1": "proparacaine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with Pomalidomide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with diflunisal.", "severity": 2}
{"drug1": "amifostine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with dipyridamole.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Pomalidomide.", "severity": 2}
{"drug1": "topiramate", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when topiramate is combined with nefazodone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with Empagliflozin.", "severity": 2}
{"drug1": "bleomycin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bleomycin is combined with leflunomide.", "severity": 2}
{"drug1": "aspirin", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "temazepam", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with protriptyline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "diazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with diazepam.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with Rosuvastatin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with Rotigotine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Desloratadine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "captopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with captopril.", "severity": 2}
{"drug1": "proparacaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Tadalafil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with Tadalafil.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with flunarizine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with ALFENTANIL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with Tasimelteon.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "decamethonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clobetasone is combined with decamethonium.", "severity": 2}
{"drug1": "Etidocaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etidocaine is combined with clonidine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with fludiazepam.", "severity": 2}
{"drug1": "Asenapine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with chloral hydrate.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with quetiapine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GALLAMINE TRIETHIODIDE is combined with Normethadone.", "severity": 2}
{"drug1": "carprofen", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Milnacipran.", "severity": 2}
{"drug1": "risperidone", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with efavirenz.", "severity": 2}
{"drug1": "prazosin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "carvedilol", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carvedilol is combined with floctafenine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Salsalate.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Ramelteon.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bezafibrate is combined with sulpiride.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Desloratadine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with fluvastatin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Fluprednidene.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with prednisone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Oxetacaine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ADAPALENE.", "severity": 2}
{"drug1": "sulindac", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Aceprometazine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with mycophenolic acid.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Metipranolol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with nadolol.", "severity": 2}
{"drug1": "butamben", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Normethadone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with felodipine.", "severity": 2}
{"drug1": "trapidil", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trapidil is combined with Apixaban.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with thiamylal.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with desipramine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Methadyl acetate.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with HEROIN.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with halothane.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with carisoprodol.", "severity": 2}
{"drug1": "butorphanol", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with polythiazide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "mefloquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluticasone furoate is combined with mefloquine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with moclobemide.", "severity": 2}
{"drug1": "bepridil", "drug2": "LEVOSIMENDAN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with LEVOSIMENDAN.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Escitalopram.", "severity": 2}
{"drug1": "prazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with MOLINDONE.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with Mirabegron.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCAINAMIDE is combined with sulpiride.", "severity": 2}
{"drug1": "Normethadone", "drug2": "cyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with cyclothiazide.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Etidronic acid.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolnaftate is combined with barnidipine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylphenidate is combined with nortriptyline.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with epirizole.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Levetiracetam.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with etizolam.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclophosphamide is combined with clozapine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydralazine is combined with Nebivolol.", "severity": 2}
{"drug1": "flunisolide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with metoclopramide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "codeine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Lurasidone.", "severity": 2}
{"drug1": "zotepine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zotepine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with Fluspirilene.", "severity": 2}
{"drug1": "glutethimide", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with flunarizine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Echothiophate.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with etizolam.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with Etoricoxib.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Teriflunomide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with pravastatin.", "severity": 2}
{"drug1": "aspirin", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with dichlorphenamide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "norfloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with norfloxacin.", "severity": 2}
{"drug1": "Butethal", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with zonisamide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with clidinium.", "severity": 2}
{"drug1": "Halazepam", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with efavirenz.", "severity": 2}
{"drug1": "Butethal", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with tiagabine.", "severity": 2}
{"drug1": "Fospropofol", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fospropofol is combined with Lormetazepam.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with diflorasone.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "methadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with methadone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Fospropofol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eletriptan is combined with Perospirone.", "severity": 2}
{"drug1": "buspirone", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with tiapride.", "severity": 2}
{"drug1": "ropinirole", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with methyclothiazide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Micafungin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with nicardipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with vigabatrin.", "severity": 2}
{"drug1": "Udenafil", "drug2": "alprostadil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Udenafil is combined with alprostadil.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Empagliflozin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pregabalin is combined with paroxetine.", "severity": 2}
{"drug1": "caffeine", "drug2": "DOXOFYLLINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when caffeine is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "trifluoperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with trifluoperazine.", "severity": 2}
{"drug1": "clemastine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clemastine is combined with Retigabine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with ethchlorvynol.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Carbocisteine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpropamide is combined with Carbocisteine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with nicotine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOBUNOLOL is combined with Cevimeline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with baclofen.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with clidinium.", "severity": 2}
{"drug1": "losartan", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with Metipranolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "losartan", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when losartan is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "zaleplon", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "sulpiride", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with butalbital.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with nifedipine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with butamben.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with papaverine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Retigabine.", "severity": 2}
{"drug1": "sulpiride", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with butamben.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with terazosin.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Etidocaine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with metoclopramide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with nicardipine.", "severity": 2}
{"drug1": "sulindac", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with NAPROXEN.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with difluprednate.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with halcinonide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Gemifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclometasone is combined with Gemifloxacin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Empagliflozin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with maprotiline.", "severity": 2}
{"drug1": "tiapride", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with cinnarizine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with dantrolene.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with ethotoin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunarizine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Idelalisib is combined with leflunomide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with duloxetine.", "severity": 2}
{"drug1": "halothane", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Perospirone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "chlordiazepoxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with chlorprothixene.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with antipyrine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with Agomelatine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Agomelatine.", "severity": 2}
{"drug1": "naratriptan", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with SERTINDOLE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "azelastine", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when azelastine is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "sulindac", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with difluprednate.", "severity": 2}
{"drug1": "cocaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cocaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with Desloratadine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylamide is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with ethotoin.", "severity": 2}
{"drug1": "isoflurane", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with triamterene.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Regorafenib.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with midazolam.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with isoxsuprine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with ZILEUTON.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with Cyamemazine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Levobupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with oxaprozin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with clidinium.", "severity": 2}
{"drug1": "minocycline", "drug2": "Alitretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minocycline is combined with Alitretinoin.", "severity": 2}
{"drug1": "enflurane", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with sertraline.", "severity": 2}
{"drug1": "codeine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "codeine", "drug2": "alprazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with alprazolam.", "severity": 2}
{"drug1": "codeine", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Eszopiclone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Iloperidone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Lofexidine.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "codeine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Remoxipride.", "severity": 2}
{"drug1": "codeine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with loxapine.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "Abemaciclib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when STIRIPENTOL is combined with Abemaciclib.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Riociguat.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tavaborole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "terconazole", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with pravastatin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with clemastine.", "severity": 2}
{"drug1": "etodolac", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with budesonide.", "severity": 2}
{"drug1": "ketamine", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with duloxetine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with Pomalidomide.", "severity": 2}
{"drug1": "ketamine", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with fluoxetine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Masoprocol is combined with Lornoxicam.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrocortisone is combined with pyridostigmine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with DEZOCINE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with bumetanide.", "severity": 2}
{"drug1": "midazolam", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with butalbital.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with chloroquine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Pinaverium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when miconazole is combined with Pinaverium.", "severity": 2}
{"drug1": "chloroquine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with equilin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with tizanidine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with promethazine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "clonazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with clonazepam.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with Perospirone.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Tramadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Tramadol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with clonidine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with METAXALONE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with metolazone.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with buspirone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERINDOPRIL is combined with salicylamide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with Deferasirox.", "severity": 2}
{"drug1": "Demecarium", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Demecarium is combined with methacholine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sitagliptin is combined with quinapril.", "severity": 2}
{"drug1": "halothane", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Pramocaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with ondansetron.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Fencamfamin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with tiagabine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLOCORTOLONE is combined with Demecarium.", "severity": 2}
{"drug1": "isoflurane", "drug2": "selegiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with selegiline.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vecuronium is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with Pimecrolimus.", "severity": 2}
{"drug1": "clozapine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Empagliflozin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with benzocaine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Mometasone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with vigabatrin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with GUANFACINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with maprotiline.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with mesoridazine.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with metoclopramide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "tetrahydrozoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with tetrahydrozoline.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with metolazone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with chlorpheniramine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with doxepin.", "severity": 2}
{"drug1": "desipramine", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Vilanterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Vilanterol.", "severity": 2}
{"drug1": "desipramine", "drug2": "isoproterenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with isoproterenol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with benzocaine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with nefazodone.", "severity": 2}
{"drug1": "pimozide", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with atorvastatin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Tenofovir disoproxil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alclofenac is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Fosphenytoin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with medrysone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with desipramine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with glutethimide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with clenbuterol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Pregabalin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with tiapride.", "severity": 2}
{"drug1": "morphine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when moclobemide is combined with Bambuterol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with methoxyflurane.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoflurophate is combined with pilocarpine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with triamterene.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with oxprenolol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Lurasidone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with zopiclone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Levocetirizine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with efavirenz.", "severity": 2}
{"drug1": "meperidine", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with bupivacaine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Ropivacaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with diltiazem.", "severity": 2}
{"drug1": "meperidine", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Etomidate.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with Aliskiren.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with felbamate.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with triprolidine.", "severity": 2}
{"drug1": "diazepam", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diazepam is combined with clomipramine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with methocarbamol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with amobarbital.", "severity": 2}
{"drug1": "etodolac", "drug2": "fludrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with fludrocortisone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with sertraline.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when griseofulvin is combined with flunarizine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with halothane.", "severity": 2}
{"drug1": "alprazolam", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with pimozide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with fosinopril.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with D-mannitol.", "severity": 2}
{"drug1": "dyclonine", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with dobutamine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "methylprednisolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with methylprednisolone.", "severity": 2}
{"drug1": "loratadine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with clidinium.", "severity": 2}
{"drug1": "alprazolam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with topiramate.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with floctafenine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with minoxidil.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Fluprednidene.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXMEDETOMIDINE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with clomipramine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with oxprenolol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with fluvoxamine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with propofol.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with ESMOLOL.", "severity": 2}
{"drug1": "propofol", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with Propacetamol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Fencamfamin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with ethotoin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "diflunisal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with diflunisal.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "isoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with isoflurane.", "severity": 2}
{"drug1": "ketorolac", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketorolac is combined with leflunomide.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with primidone.", "severity": 2}
{"drug1": "Amrinone", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Amrinone is combined with lovastatin.", "severity": 2}
{"drug1": "cisplatin", "drug2": "topotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cisplatin is combined with topotecan.", "severity": 2}
{"drug1": "oxazepam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with tetracaine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with clidinium.", "severity": 2}
{"drug1": "diclofenac", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with betamethasone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Iloperidone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "PERINDOPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with trandolapril.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with polythiazide.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with trimipramine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with clomipramine.", "severity": 2}
{"drug1": "quinapril", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "sulindac", "drug2": "Mometasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Mometasone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Drospirenone.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NITROUS ACID is combined with methyclothiazide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with difluprednate.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with brotizolam.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "ceftriaxone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CALCIUM GLUCONATE is combined with ceftriaxone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Levetiracetam.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with nefazodone.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Normethadone.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitric oxide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Agomelatine is combined with doxepin.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Ketobemidone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ADAPALENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ADAPALENE.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "methysergide", "drug2": "Ivacaftor", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Ivacaftor.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with dipyridamole.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Aliskiren.", "severity": 2}
{"drug1": "methysergide", "drug2": "Lomitapide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Lomitapide.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Fesoterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procyclidine is combined with Fesoterodine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with chlorprothixene.", "severity": 2}
{"drug1": "triazolam", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with tiapride.", "severity": 2}
{"drug1": "secobarbital", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with gabapentin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with fludiazepam.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with chloral hydrate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with rasagiline.", "severity": 2}
{"drug1": "loxapine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with gabapentin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Methadyl acetate.", "severity": 2}
{"drug1": "pergolide", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with danazol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with pilocarpine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "paramethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with paramethasone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with Cyamemazine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with tranylcypromine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Propoxycaine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Pramocaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with promethazine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with tretinoin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with indapamide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ETOFENAMATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "dibucaine", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "nicergoline", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with nifedipine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "miconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with miconazole.", "severity": 2}
{"drug1": "meprobamate", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with clidinium.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Iloperidone.", "severity": 2}
{"drug1": "meprobamate", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with benzocaine.", "severity": 2}
{"drug1": "Trospium", "drug2": "Vecuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with Vecuronium.", "severity": 2}
{"drug1": "prazosin", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mecamylamine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Trospium", "drug2": "pancuronium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with pancuronium.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with triprolidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Tapentadol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Escitalopram.", "severity": 2}
{"drug1": "Perospirone", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with methylphenidate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Perospirone is combined with methocarbamol.", "severity": 2}
{"drug1": "Normethadone", "drug2": "TRICHLOROETHYLENE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Fencamfamin.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Ethylmorphine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "oxazepam", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with enflurane.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with Pizotifen.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methscopolamine is combined with meperidine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with Tolcapone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with ramipril.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with KETAZOLAM.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "valsartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with valsartan.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with etodolac.", "severity": 2}
{"drug1": "efavirenz", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when efavirenz is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with ramipril.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with brotizolam.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "paromomycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with paromomycin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Alvimopan.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with Fospropofol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with zotepine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with MELPERONE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with benazepril.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "losartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with losartan.", "severity": 2}
{"drug1": "benazepril", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with indapamide.", "severity": 2}
{"drug1": "thiopental", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with tizanidine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when difluprednate is combined with pyridostigmine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Epirubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Epirubicin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "nalidixic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with nalidixic acid.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with Aliskiren.", "severity": 2}
{"drug1": "pergolide", "drug2": "tetracycline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with tetracycline.", "severity": 2}
{"drug1": "tetracaine", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with loratadine.", "severity": 2}
{"drug1": "tetracaine", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with imipramine.", "severity": 2}
{"drug1": "codeine", "drug2": "theobromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with theobromine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "clofazimine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with clofazimine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "plicamycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with plicamycin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "betamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with betamethasone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "cyclophosphamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bivalirudin is combined with cyclophosphamide.", "severity": 2}
{"drug1": "sulpiride", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with trimipramine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoproterenol is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "sulpiride", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with procaine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with mesoridazine.", "severity": 2}
{"drug1": "halothane", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Lormetazepam.", "severity": 2}
{"drug1": "tiagabine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with fexofenadine.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Metipranolol.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with dantrolene.", "severity": 2}
{"drug1": "dibucaine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxymorphone is combined with methyclothiazide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with tiagabine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "pentostatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tacrolimus is combined with pentostatin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with zonisamide.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with fexofenadine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "chloroxine", "drug2": "cinnarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroxine is combined with cinnarizine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with benazepril.", "severity": 2}
{"drug1": "flunisolide", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunisolide is combined with NICORANDIL.", "severity": 2}
{"drug1": "nystatin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nystatin is combined with Amrinone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Mirabegron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with Mirabegron.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with prazepam.", "severity": 2}
{"drug1": "selegiline", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with bifonazole.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with tizanidine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "FLUOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "selegiline", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with thiothixene.", "severity": 2}
{"drug1": "selegiline", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with Thioproperazine.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with duloxetine.", "severity": 2}
{"drug1": "codeine", "drug2": "FLUPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with fluoxetine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Cyamemazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "butabarbital", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with risperidone.", "severity": 2}
{"drug1": "butabarbital", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with meclizine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with nortriptyline.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with GUANFACINE.", "severity": 2}
{"drug1": "meprobamate", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meprobamate is combined with vigabatrin.", "severity": 2}
{"drug1": "Pipazethate", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipazethate is combined with mecamylamine.", "severity": 2}
{"drug1": "isradipine", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "diltiazem", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with diltiazem.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Tolcapone.", "severity": 2}
{"drug1": "triazolam", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with tetracaine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with nicardipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with Lurasidone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with enflurane.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with moclobemide.", "severity": 2}
{"drug1": "bepridil", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with sevoflurane.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with flunitrazepam.", "severity": 2}
{"drug1": "sotalol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with Riociguat.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hyoscyamine is combined with butorphanol.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with SERTINDOLE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Mephobarbital.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with chlorothiazide.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tapentadol is combined with bumetanide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with Remoxipride.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with nicotine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Cevimeline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with ESMOLOL.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epoprostenol is combined with dichlorphenamide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with baclofen.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with Halazepam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with ALFENTANIL.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "BENZYDAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketoprofen is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "methyldopa", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyldopa is combined with dichlorphenamide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with proparacaine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "sulfasalazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with sulfasalazine.", "severity": 2}
{"drug1": "quazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with butamben.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with indapamide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Frovatriptan.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with lisinopril.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Lurasidone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with butamben.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with ethchlorvynol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Etoricoxib.", "severity": 2}
{"drug1": "Melatonin", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with chloral hydrate.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with baclofen.", "severity": 2}
{"drug1": "butorphanol", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with amoxapine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with nortriptyline.", "severity": 2}
{"drug1": "butalbital", "drug2": "trimipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with trimipramine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Pomalidomide.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "nimodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with nimodipine.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with rasagiline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with Retigabine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Iloperidone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "periciazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with periciazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with quinapril.", "severity": 2}
{"drug1": "lidocaine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lidocaine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with glutethimide.", "severity": 2}
{"drug1": "meperidine", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with dyclonine.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with Methadyl acetate.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Canagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolazoline is combined with Canagliflozin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with metoclopramide.", "severity": 2}
{"drug1": "quazepam", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Desloratadine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "DESFLURANE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with DESFLURANE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when venlafaxine is combined with Fluspirilene.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with loratadine.", "severity": 2}
{"drug1": "tropicamide", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tropicamide is combined with nalbuphine.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with imipramine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with tolfenamic acid.", "severity": 2}
{"drug1": "resveratrol", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when resveratrol is combined with flunisolide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with proparacaine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Fluprednidene.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with Agomelatine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with tolfenamic acid.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Pipotiazine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "thiothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with thiothixene.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Thioproperazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Thioproperazine.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Zuclopenthixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rizatriptan is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ramelteon is combined with Flibanserin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "diflorasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERATRODAST is combined with diflorasone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with nifedipine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with CARTEOLOL.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiagabine is combined with Levocetirizine.", "severity": 2}
{"drug1": "propofol", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with propoxyphene.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with metolazone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Eszopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Eszopiclone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Lercanidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrendipine is combined with sotalol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with triflupromazine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with Remoxipride.", "severity": 2}
{"drug1": "olanzapine", "drug2": "loxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with loxapine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Estrone sulfate is combined with metoclopramide.", "severity": 2}
{"drug1": "minoxidil", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with CARTEOLOL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with metolazone.", "severity": 2}
{"drug1": "methysergide", "drug2": "astemizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with astemizole.", "severity": 2}
{"drug1": "valsartan", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Droxicam.", "severity": 2}
{"drug1": "valsartan", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with CLONIXIN.", "severity": 2}
{"drug1": "risperidone", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Perospirone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolic acid is combined with halcinonide.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with levodopa.", "severity": 2}
{"drug1": "promethazine", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Flibanserin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with dantrolene.", "severity": 2}
{"drug1": "tolmetin", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "tiaprofenic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "sulindac", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulindac is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with fluoxetine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loratadine is combined with Ramelteon.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Milnacipran.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with buspirone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with oxycodone.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with codeine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with nifedipine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Torasemide.", "severity": 2}
{"drug1": "methysergide", "drug2": "Voriconazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Voriconazole.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "azelastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with azelastine.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with primidone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with bupropion.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Escitalopram.", "severity": 2}
{"drug1": "methysergide", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with dexamethasone.", "severity": 2}
{"drug1": "Spirapril", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Spirapril is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "methysergide", "drug2": "SAQUINAVIR", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "toremifene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with toremifene.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Regorafenib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Regorafenib.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with clidinium.", "severity": 2}
{"drug1": "amcinonide", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amcinonide is combined with enoxacin.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Gabapentin enacarbil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with Gabapentin enacarbil.", "severity": 2}
{"drug1": "Droxicam", "drug2": "DEFLAZACORT", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "benztropine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benztropine is combined with Normethadone.", "severity": 2}
{"drug1": "proparacaine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "potassium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydromorphone is combined with potassium ion.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with triprolidine.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with methocarbamol.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clevidipine is combined with Empagliflozin.", "severity": 2}
{"drug1": "methadone", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Asenapine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Canrenoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Canrenoic acid.", "severity": 2}
{"drug1": "suprofen", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with brotizolam.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with HEROIN.", "severity": 2}
{"drug1": "Articaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with scopolamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxazosin is combined with AMILORIDE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimodipine is combined with fosinopril.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with desoximetasone.", "severity": 2}
{"drug1": "ipratropium", "drug2": "trihexyphenidyl", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with trihexyphenidyl.", "severity": 2}
{"drug1": "docetaxel", "drug2": "mechlorethamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with mechlorethamine.", "severity": 2}
{"drug1": "Micafungin", "drug2": "barnidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Micafungin is combined with barnidipine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with amisulpride.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclofenamic acid is combined with mycophenolic acid.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propoxyphene is combined with Halazepam.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with Empagliflozin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Pipamperone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with Pramocaine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Loxoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Loxoprofen.", "severity": 2}
{"drug1": "fosinopril", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with carprofen.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "cisapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with cisapride.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ISOSORBIDE MONONITRATE is combined with hydralazine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with nortriptyline.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with amoxapine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with MOLINDONE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with VERAPAMIL.", "severity": 2}
{"drug1": "butorphanol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with tiapride.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxaprozin is combined with flumethasone.", "severity": 2}
{"drug1": "amifostine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amifostine is combined with nitroglycerin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with epirizole.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "butalbital", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with doxepin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with clonidine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clopidogrel is combined with Apixaban.", "severity": 2}
{"drug1": "risperidone", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with Halazepam.", "severity": 2}
{"drug1": "risperidone", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with ALFENTANIL.", "severity": 2}
{"drug1": "valsartan", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with Dapagliflozin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Lofexidine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with leflunomide.", "severity": 2}
{"drug1": "quinapril", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with cilazapril.", "severity": 2}
{"drug1": "reserpine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Lacidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Lacidipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with oxycodone.", "severity": 2}
{"drug1": "pargyline", "drug2": "buspirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pargyline is combined with buspirone.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Benidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with Benidipine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NAPROXEN is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ETHACRYNIC ACID is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Propoxycaine", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propoxycaine is combined with Iloperidone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Olopatadine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "dobutamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with dobutamine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with manidipine.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "fenoldopam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with fenoldopam.", "severity": 2}
{"drug1": "metolazone", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with mecamylamine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with salicylamide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "epinastine", "drug2": "DEOXYCHOLIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinastine is combined with DEOXYCHOLIC ACID.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoclopramide is combined with amitriptyline.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with Escitalopram.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with tetracaine.", "severity": 2}
{"drug1": "promazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "butamben", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with scopolamine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "triamterene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydroflumethiazide is combined with triamterene.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with nifedipine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "HEROIN", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with flunitrazepam.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenylephrine is combined with ritodrine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Ketobemidone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phenoxybenzamine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "proparacaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "dihydroergotamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with dihydroergotamine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with amitriptyline.", "severity": 2}
{"drug1": "Articaine", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Difenoxin.", "severity": 2}
{"drug1": "valsartan", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with epirizole.", "severity": 2}
{"drug1": "terconazole", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with nisoldipine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tiotropium is combined with Normethadone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with acetylcholine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paliperidone is combined with flunitrazepam.", "severity": 2}
{"drug1": "cetirizine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cetirizine is combined with Pizotifen.", "severity": 2}
{"drug1": "chloroquine", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with prilocaine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "oxycodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Netupitant is combined with oxycodone.", "severity": 2}
{"drug1": "morphine", "drug2": "nitroglycerin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with nitroglycerin.", "severity": 2}
{"drug1": "morphine", "drug2": "lisinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with lisinopril.", "severity": 2}
{"drug1": "morphine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with procaine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "cyclobenzaprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "propofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with propofol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with epirizole.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with papaverine.", "severity": 2}
{"drug1": "triazolam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with felbamate.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Asenapine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Almotriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Almotriptan.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with flunisolide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with difluprednate.", "severity": 2}
{"drug1": "enalapril", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with nicardipine.", "severity": 2}
{"drug1": "tiapride", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with CYCLIZINE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with halcinonide.", "severity": 2}
{"drug1": "papaverine", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with Bretylium.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Amrinone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Anidulafungin is combined with Amrinone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Aliskiren.", "severity": 2}
{"drug1": "pergolide", "drug2": "olanzapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with olanzapine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with fexofenadine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Normethadone is combined with rasagiline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Teriflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with Teriflunomide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Temsirolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with Temsirolimus.", "severity": 2}
{"drug1": "amoxapine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "zaleplon", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with methoxyflurane.", "severity": 2}
{"drug1": "betamethasone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betamethasone is combined with enoxacin.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with Echothiophate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amoxapine is combined with moclobemide.", "severity": 2}
{"drug1": "epirizole", "drug2": "Cis-mdp", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Cis-mdp.", "severity": 2}
{"drug1": "thiothixene", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with imipramine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Echothiophate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prednisone is combined with Echothiophate.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olsalazine is combined with DESONIDE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with loratadine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with cetirizine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with etizolam.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "protriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with protriptyline.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with Pefloxacin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Efonidipine is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with bromazepam.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with Eplerenone.", "severity": 2}
{"drug1": "docetaxel", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when docetaxel is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorpheniramine is combined with doxepin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with methazolamide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoldopam is combined with SUFENTANIL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with Normethadone.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "flurbiprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with flurbiprofen.", "severity": 2}
{"drug1": "Butethal", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with paroxetine.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AMILORIDE is combined with Bretylium.", "severity": 2}
{"drug1": "butorphanol", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butorphanol is combined with mesoridazine.", "severity": 2}
{"drug1": "trazodone", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with methoxyflurane.", "severity": 2}
{"drug1": "carprofen", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with budesonide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "butabarbital", "drug2": "dyclonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with dyclonine.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with felbamate.", "severity": 2}
{"drug1": "Etomidate", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with mepivacaine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Desloratadine.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with Bretylium.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with Pregabalin.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with desipramine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with clonidine.", "severity": 2}
{"drug1": "propofol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with tiagabine.", "severity": 2}
{"drug1": "propofol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with Tasimelteon.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with lithium ion.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with Desloratadine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mesoridazine is combined with mepivacaine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with etodolac.", "severity": 2}
{"drug1": "BENZNIDAZOLE", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZNIDAZOLE is combined with leflunomide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with Iloperidone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceclofenac is combined with Ciclesonide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with chloroquine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with Lorcaserin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with difluprednate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Teriflunomide is combined with halcinonide.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with clidinium.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "dicumarol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with dicumarol.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "pyridostigmine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludrocortisone is combined with pyridostigmine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with papaverine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with clidinium.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Ifenprodil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ibrutinib is combined with Ifenprodil.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Lormetazepam.", "severity": 2}
{"drug1": "clonidine", "drug2": "nifedipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with nifedipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "clonidine", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with papaverine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with indapamide.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Nabilone", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with betaxolol.", "severity": 2}
{"drug1": "codeine", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Pomalidomide.", "severity": 2}
{"drug1": "Difenoxin", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Difenoxin is combined with venlafaxine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "METHAMPHETAMINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terbutaline is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Trovafloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with Trovafloxacin.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when NATAMYCIN is combined with VERAPAMIL.", "severity": 2}
{"drug1": "doxycycline", "drug2": "dapsone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxycycline is combined with dapsone.", "severity": 2}
{"drug1": "loxapine", "drug2": "diphenhydramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with diphenhydramine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with tizanidine.", "severity": 2}
{"drug1": "procaine", "drug2": "cocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with cocaine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "antipyrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with antipyrine.", "severity": 2}
{"drug1": "procaine", "drug2": "ondansetron", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when procaine is combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with HEROIN.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Levobupivacaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "PAMIDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with PAMIDRONIC ACID.", "severity": 2}
{"drug1": "cabergoline", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with MELPERONE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with zotepine.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with VERAPAMIL.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with oxprenolol.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "amcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with amcinonide.", "severity": 2}
{"drug1": "apomorphine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiamylal is combined with chlorzoxazone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Torasemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Torasemide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when protriptyline is combined with Desloratadine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PIRFENIDONE is combined with Clodronic Acid.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "PREDNICARBATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenbutazone is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "secobarbital", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with zaleplon.", "severity": 2}
{"drug1": "secobarbital", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with mepivacaine.", "severity": 2}
{"drug1": "Artemether", "drug2": "manidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Artemether is combined with manidipine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with fexofenadine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "quinidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pirenzepine is combined with quinidine.", "severity": 2}
{"drug1": "morniflumate", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with Etoricoxib.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with MOLINDONE.", "severity": 2}
{"drug1": "spironolactone", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with irbesartan.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nitroprusside is combined with sotalol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with propranolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with enflurane.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when spironolactone is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "GUANFACINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYPROHEPTADINE is combined with GUANFACINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Aceprometazine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Pentyl nitrite", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with Pentyl nitrite.", "severity": 2}
{"drug1": "sertraline", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with amisulpride.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Icatibant", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Icatibant.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Decitabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Decitabine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Sunitinib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with Sunitinib.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sodium oxybate is combined with sertraline.", "severity": 2}
{"drug1": "Torasemide", "drug2": "doxorubicin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with doxorubicin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Milnacipran.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Pipamperone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "budesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etoricoxib is combined with budesonide.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with Difenoxin.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Methadyl acetate is combined with tiapride.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with butamben.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Ethylmorphine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Fencamfamin.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "METHSUXIMIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Halazepam", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with baclofen.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with Aceprometazine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with MOLINDONE.", "severity": 2}
{"drug1": "meperidine", "drug2": "SERTINDOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with SERTINDOLE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when secobarbital is combined with nitrous oxide.", "severity": 2}
{"drug1": "loxapine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with Escitalopram.", "severity": 2}
{"drug1": "midazolam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with oxprenolol.", "severity": 2}
{"drug1": "pergolide", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with thiopental.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "methscopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dicyclomine is combined with methscopolamine.", "severity": 2}
{"drug1": "Pizotifen", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pizotifen is combined with sertraline.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Bretylium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Bretylium.", "severity": 2}
{"drug1": "nicergoline", "drug2": "anastrozole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with anastrozole.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "flurandrenolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CLONIXIN is combined with flurandrenolide.", "severity": 2}
{"drug1": "nicergoline", "drug2": "clarithromycin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with clarithromycin.", "severity": 2}
{"drug1": "Halazepam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with imipramine.", "severity": 2}
{"drug1": "Halazepam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with loratadine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "meclizine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with tiagabine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with Halazepam.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with Rosuvastatin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Mephobarbital.", "severity": 2}
{"drug1": "sotalol", "drug2": "papaverine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sotalol is combined with papaverine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with floctafenine.", "severity": 2}
{"drug1": "doxepin", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxepin is combined with clenbuterol.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lacidipine is combined with fluvastatin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Aripiprazole.", "severity": 2}
{"drug1": "Halazepam", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with prazepam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Conivaptan is combined with D-mannitol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with meperidine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TASOSARTAN is combined with leflunomide.", "severity": 2}
{"drug1": "Halazepam", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with oxprenolol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "morphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with morphine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with Apixaban.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Etoricoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with Etoricoxib.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "LEVOFLOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ciclesonide is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "etizolam", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "temazepam", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with nortriptyline.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TETRABENAZINE is combined with Escitalopram.", "severity": 2}
{"drug1": "amisulpride", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with benzyl alcohol.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with mesalamine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "D-mannitol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with D-mannitol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with Ketobemidone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "furazolidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with furazolidone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with carisoprodol.", "severity": 2}
{"drug1": "isoflurane", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isoflurane is combined with enflurane.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lurasidone is combined with Fospropofol.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Cevimeline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Demecarium is combined with Cevimeline.", "severity": 2}
{"drug1": "Demecarium", "drug2": "nicotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Demecarium is combined with nicotine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Oxetacaine.", "severity": 2}
{"drug1": "propofol", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with AMILORIDE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with Pipotiazine.", "severity": 2}
{"drug1": "propofol", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with ethosuximide.", "severity": 2}
{"drug1": "propofol", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with doxazosin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Normethadone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metoprolol is combined with Empagliflozin.", "severity": 2}
{"drug1": "propofol", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with labetalol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with butalbital.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENDROFLUMETHIAZIDE is combined with prazosin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "vigabatrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with vigabatrin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Escitalopram is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with benzocaine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Propacetamol.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sumatriptan is combined with Aceprometazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mycophenolate mofetil is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Melatonin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Melatonin.", "severity": 2}
{"drug1": "medrysone", "drug2": "cinoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when medrysone is combined with cinoxacin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "DESMOPRESSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with DESMOPRESSIN.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with cetirizine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "epirizole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOEXIPRIL is combined with epirizole.", "severity": 2}
{"drug1": "gabapentin", "drug2": "mesoridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with mesoridazine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with maprotiline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prochlorperazine is combined with METAXALONE.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "enflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diphenhydramine is combined with enflurane.", "severity": 2}
{"drug1": "prazosin", "drug2": "enalapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with enalapril.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "ROSOXACIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fluocinonide is combined with ROSOXACIN.", "severity": 2}
{"drug1": "loxapine", "drug2": "quetiapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with quetiapine.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorprothixene is combined with doxepin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with carisoprodol.", "severity": 2}
{"drug1": "buspirone", "drug2": "sumatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with sumatriptan.", "severity": 2}
{"drug1": "Tramadol", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with codeine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Alvimopan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Alvimopan.", "severity": 2}
{"drug1": "buspirone", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when buspirone is combined with METAXALONE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Fencamfamin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "zolmitriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with zolmitriptan.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Ethylmorphine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with pimozide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "butalbital", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with primidone.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "acetylcholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with acetylcholine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with desipramine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with Retigabine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with HEROIN.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "floctafenine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with floctafenine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Enalaprilat is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VERAPAMIL is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Etomidate", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with DEZOCINE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with methazolamide.", "severity": 2}
{"drug1": "Articaine", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with tetracaine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "mepivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with mepivacaine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with zaleplon.", "severity": 2}
{"drug1": "etodolac", "drug2": "Clodronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Clodronic Acid.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Flibanserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with Flibanserin.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Arbekacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Arbekacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with difluprednate.", "severity": 2}
{"drug1": "benazepril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benazepril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Salsalate", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Salsalate is combined with halcinonide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Lumiracoxib.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with Tolcapone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with doxepin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with niflumic acid.", "severity": 2}
{"drug1": "selegiline", "drug2": "perphenazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when selegiline is combined with perphenazine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "halcinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with halcinonide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amisulpride is combined with Tolcapone.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with maprotiline.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "mesalamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ifenprodil is combined with mesalamine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Milnacipran.", "severity": 2}
{"drug1": "perphenazine", "drug2": "nortriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with nortriptyline.", "severity": 2}
{"drug1": "brotizolam", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with loratadine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "dopamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzphetamine is combined with dopamine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with chlorpheniramine.", "severity": 2}
{"drug1": "dyclonine", "drug2": "amitriptyline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with amitriptyline.", "severity": 2}
{"drug1": "dyclonine", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with Tolcapone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with pimozide.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "acetazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with acetazolamide.", "severity": 2}
{"drug1": "brotizolam", "drug2": "imipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with imipramine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorzoxazone is combined with Olopatadine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cerulenin is combined with Clevidipine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with terazosin.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with tizanidine.", "severity": 2}
{"drug1": "codeine", "drug2": "estazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with estazolam.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "chlorzoxazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with chlorzoxazone.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Droxicam is combined with CLONIXIN.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCINOLONE ACETONIDE is combined with Pefloxacin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with meclizine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with cilazapril.", "severity": 2}
{"drug1": "desipramine", "drug2": "PIRBUTEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when desipramine is combined with PIRBUTEROL.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with Tasimelteon.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with brotizolam.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with Levocetirizine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Oxybuprocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Oxybuprocaine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "epoprostenol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with epoprostenol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "triazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with triazolam.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Difenoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with Difenoxin.", "severity": 2}
{"drug1": "ethchlorvynol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethchlorvynol is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trihexyphenidyl is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "enoxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamcinolone is combined with enoxacin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "methyclothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with methyclothiazide.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when itraconazole is combined with Pregabalin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "topiramate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with topiramate.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with Retigabine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ropivacaine is combined with dipyridamole.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lorcaserin is combined with amisulpride.", "severity": 2}
{"drug1": "Melatonin", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with felbamate.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Propoxycaine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with midazolam.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with Pramocaine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "vinblastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Voriconazole is combined with vinblastine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "AMILORIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with AMILORIDE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "oxymorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with oxymorphone.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with Agomelatine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRIMETHAPHAN is combined with codeine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when alprazolam is combined with Milnacipran.", "severity": 2}
{"drug1": "Tramadol", "drug2": "zopiclone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with zopiclone.", "severity": 2}
{"drug1": "barnidipine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when barnidipine is combined with fosinopril.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "enflurane", "drug2": "VALPROIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "halothane", "drug2": "timolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with timolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "promethazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when GUANFACINE is combined with promethazine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with tizanidine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with furosemide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with codeine.", "severity": 2}
{"drug1": "methysergide", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with hydralazine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with moclobemide.", "severity": 2}
{"drug1": "paroxetine", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when paroxetine is combined with zotepine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Treprostinil is combined with fenoprofen.", "severity": 2}
{"drug1": "carprofen", "drug2": "homoharringtonine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with homoharringtonine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with terbutaline.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Mephobarbital.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "doxepin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SERTINDOLE is combined with doxepin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with maprotiline.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when demeclocycline is combined with tretinoin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with lithium ion.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Lurasidone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "benzocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with benzocaine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Etidocaine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "metolazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with metolazone.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "fosinopril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with fosinopril.", "severity": 2}
{"drug1": "Torasemide", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with CARTEOLOL.", "severity": 2}
{"drug1": "nicergoline", "drug2": "modafinil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with modafinil.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Posaconazole is combined with eperisone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "TETRABENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VORTIOXETINE is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "brotizolam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with zotepine.", "severity": 2}
{"drug1": "brotizolam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brotizolam is combined with MELPERONE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clorazepate is combined with Aceprometazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with felbamate.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with Clevidipine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HYDROCODONE is combined with spironolactone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with bromazepam.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bumetanide is combined with Riociguat.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "DIHYDROCODEINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "Fosphenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with equilin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with HEROIN.", "severity": 2}
{"drug1": "cabergoline", "drug2": "metyrapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with metyrapone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sulfamethoxazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "temazepam", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with MELPERONE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "glyburide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with glyburide.", "severity": 2}
{"drug1": "levorphanol", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with HEROIN.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Ramelteon.", "severity": 2}
{"drug1": "propofol", "drug2": "rasagiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with rasagiline.", "severity": 2}
{"drug1": "butamben", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with baclofen.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with amisulpride.", "severity": 2}
{"drug1": "methadone", "drug2": "Fluspirilene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with Fluspirilene.", "severity": 2}
{"drug1": "lisinopril", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "felbamate", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when felbamate is combined with flunarizine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Metipranolol.", "severity": 2}
{"drug1": "tetracaine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tetracaine is combined with Levetiracetam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "dichlorphenamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when hydrochlorothiazide is combined with dichlorphenamide.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tubocurarine is combined with buprenorphine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Lormetazepam.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "NAPROXEN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with NAPROXEN.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethopropazine is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with mecamylamine.", "severity": 2}
{"drug1": "quazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with Desloratadine.", "severity": 2}
{"drug1": "quazepam", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quazepam is combined with Etomidate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Desloratadine.", "severity": 2}
{"drug1": "butabarbital", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with oxprenolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with terazosin.", "severity": 2}
{"drug1": "morphine", "drug2": "dibucaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with dibucaine.", "severity": 2}
{"drug1": "morphine", "drug2": "CARTEOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with CARTEOLOL.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with Pizotifen.", "severity": 2}
{"drug1": "Naftifine", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tranylcypromine is combined with dipivefrin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with chloral hydrate.", "severity": 2}
{"drug1": "trazodone", "drug2": "brotizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trazodone is combined with brotizolam.", "severity": 2}
{"drug1": "thioridazine", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with meclizine.", "severity": 2}
{"drug1": "benzocaine", "drug2": "benzyl alcohol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Etomidate is combined with Tasimelteon.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with loteprednol.", "severity": 2}
{"drug1": "Halazepam", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halazepam is combined with Oxetacaine.", "severity": 2}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "Nintedanib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 3,4-Dihydroxybenzaldehyde is combined with Nintedanib.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Paliperidone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Tasimelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with Tasimelteon.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "tolfenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with tolfenamic acid.", "severity": 2}
{"drug1": "cabergoline", "drug2": "bifonazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with bifonazole.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with Lornoxicam.", "severity": 2}
{"drug1": "furosemide", "drug2": "Eprosartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furosemide is combined with Eprosartan.", "severity": 2}
{"drug1": "enalapril", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enalapril is combined with niflumic acid.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Flupentixol is combined with pimozide.", "severity": 2}
{"drug1": "pimozide", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Etomidate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with memantine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Gatifloxacin.", "severity": 2}
{"drug1": "morphine", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Perospirone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with Ropivacaine.", "severity": 2}
{"drug1": "pimozide", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pimozide is combined with bupivacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Etomidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Etomidate.", "severity": 2}
{"drug1": "propofol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with Ropivacaine.", "severity": 2}
{"drug1": "thiothixene", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiothixene is combined with bupivacaine.", "severity": 2}
{"drug1": "temazepam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with Ropivacaine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tolcapone is combined with dipyridamole.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Choline magnesium trisalicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "Calcipotriol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Doxercalciferol is combined with Calcipotriol.", "severity": 2}
{"drug1": "epirizole", "drug2": "Droxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with Droxicam.", "severity": 2}
{"drug1": "imipramine", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with fexofenadine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with atorvastatin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with duloxetine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Ditazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when salicylic acid is combined with Ditazole.", "severity": 2}
{"drug1": "zopiclone", "drug2": "fluoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zopiclone is combined with fluoxetine.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Levetiracetam.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "fluvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sertaconazole is combined with fluvastatin.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "SUFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with SUFENTANIL.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "Pomalidomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CYCLIZINE is combined with Pomalidomide.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "TAMSULOSIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "clozapine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with Normethadone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with Eplerenone.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LEVOSIMENDAN is combined with methazolamide.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "mycophenolic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ethylmorphine is combined with tiagabine.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "Milnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PARALDEHYDE is combined with Milnacipran.", "severity": 2}
{"drug1": "fludiazepam", "drug2": "butamben", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fludiazepam is combined with butamben.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Frovatriptan is combined with Aceprometazine.", "severity": 2}
{"drug1": "ethanol", "drug2": "didanosine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with didanosine.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Lurasidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with Lurasidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with pimozide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with chlorpheniramine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with Pramocaine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "clomipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with clomipramine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when IMIQUIMOD is combined with leflunomide.", "severity": 2}
{"drug1": "zonisamide", "drug2": "citalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zonisamide is combined with citalopram.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHAMPHETAMINE is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ALENDRONIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenoprofen is combined with ALENDRONIC ACID.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "celecoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Telmisartan is combined with celecoxib.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with meclizine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Tiludronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolmetin is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "galanthamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUOCORTOLONE is combined with galanthamine.", "severity": 2}
{"drug1": "atenolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when atenolol is combined with pilocarpine.", "severity": 2}
{"drug1": "imipramine", "drug2": "terazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when imipramine is combined with terazosin.", "severity": 2}
{"drug1": "promazine", "drug2": "CHLOROPROCAINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with CHLOROPROCAINE.", "severity": 2}
{"drug1": "promethazine", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with isocarboxazid.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when vigabatrin is combined with flunarizine.", "severity": 2}
{"drug1": "promazine", "drug2": "flurazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with flurazepam.", "severity": 2}
{"drug1": "Naftifine", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with etodolac.", "severity": 2}
{"drug1": "fenbufen", "drug2": "difluprednate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fenbufen is combined with difluprednate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "flunisolide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurbiprofen is combined with flunisolide.", "severity": 2}
{"drug1": "methadone", "drug2": "chlormezanone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methadone is combined with chlormezanone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with hydrocortisone.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with clonidine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Naftifine is combined with ZILEUTON.", "severity": 2}
{"drug1": "nicardipine", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicardipine is combined with dipyridamole.", "severity": 2}
{"drug1": "methysergide", "drug2": "Atomoxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with Atomoxetine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "oxaprozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with oxaprozin.", "severity": 2}
{"drug1": "suprofen", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when suprofen is combined with Risedronic acid.", "severity": 2}
{"drug1": "carprofen", "drug2": "meclofenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with meclofenamic acid.", "severity": 2}
{"drug1": "methysergide", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methysergide is combined with clemastine.", "severity": 2}
{"drug1": "SULFALENE", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SULFALENE is combined with mecamylamine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Mephobarbital is combined with Agomelatine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when brimonidine is combined with nefazodone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with desipramine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dextromethorphan is combined with Asenapine.", "severity": 2}
{"drug1": "midazolam", "drug2": "zaleplon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with zaleplon.", "severity": 2}
{"drug1": "Melatonin", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with thiamylal.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "etodolac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with etodolac.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "ZILEUTON", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Olmesartan is combined with ZILEUTON.", "severity": 2}
{"drug1": "Melatonin", "drug2": "halothane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Melatonin is combined with halothane.", "severity": 2}
{"drug1": "primidone", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with duloxetine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aripiprazole is combined with bromazepam.", "severity": 2}
{"drug1": "primidone", "drug2": "METHOHEXITAL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when primidone is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ERGOTAMINE is combined with irinotecan.", "severity": 2}
{"drug1": "naratriptan", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with metoclopramide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with ritodrine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "minoxidil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nabilone is combined with minoxidil.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with methoxyflurane.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "VERAPAMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxprenolol is combined with VERAPAMIL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "methotrexate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with methotrexate.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUPHENAZINE is combined with HEROIN.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with nalbuphine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with Empagliflozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "CAPECITABINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pimecrolimus is combined with CAPECITABINE.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with Nabilone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "fenoprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with fenoprofen.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with Nebivolol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "prilocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with prilocaine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with clonidine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bosutinib is combined with clozapine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "progesterone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with progesterone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Arotinolol is combined with sotalol.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Levetiracetam.", "severity": 2}
{"drug1": "promethazine", "drug2": "Cyamemazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with Cyamemazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with Pipamperone.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxyphenonium is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "apraclonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with apraclonidine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Telmisartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with Telmisartan.", "severity": 2}
{"drug1": "timolol", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when timolol is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "prazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with prazosin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with Fospropofol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "methyldopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromocriptine is combined with methyldopa.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Nabilone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Nabilone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Asenapine.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 6-Mercaptopurine is combined with clozapine.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "loratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pipamperone is combined with loratadine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "brimonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with brimonidine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "alclofenac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with alclofenac.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Dapagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Dapagliflozin.", "severity": 2}
{"drug1": "clonidine", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with Ramelteon.", "severity": 2}
{"drug1": "olanzapine", "drug2": "butorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when olanzapine is combined with butorphanol.", "severity": 2}
{"drug1": "clonidine", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clonidine is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "ergocalciferol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paricalcitol is combined with ergocalciferol.", "severity": 2}
{"drug1": "promazine", "drug2": "Agomelatine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with Agomelatine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Rotigotine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Rotigotine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "phenylpropanolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when furazolidone is combined with phenylpropanolamine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "nitrendipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with nitrendipine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "methazolamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ESMOLOL is combined with methazolamide.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "chlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with chlorothiazide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "gemfibrozil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cabergoline is combined with gemfibrozil.", "severity": 2}
{"drug1": "tiapride", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiapride is combined with Levocetirizine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "oxyphenbutazone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "ketamine", "drug2": "4-Hydroxybutanoic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with 4-Hydroxybutanoic acid.", "severity": 2}
{"drug1": "aspirin", "drug2": "nabumetone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when aspirin is combined with nabumetone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "Tolcapone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with Tolcapone.", "severity": 2}
{"drug1": "lorazepam", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with hydromorphone.", "severity": 2}
{"drug1": "Talniflumate", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Talniflumate is combined with resveratrol.", "severity": 2}
{"drug1": "oxazepam", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with scopolamine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with hydromorphone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mepivacaine is combined with scopolamine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "fenbufen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with fenbufen.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methocarbamol is combined with clonidine.", "severity": 2}
{"drug1": "donepezil", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when donepezil is combined with methacholine.", "severity": 2}
{"drug1": "promazine", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with cetirizine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "nitrous oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIPHENOXYLATE is combined with nitrous oxide.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Nebivolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with Nebivolol.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Ciclesonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Ciclesonide.", "severity": 2}
{"drug1": "etizolam", "drug2": "Pramocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Pramocaine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amphotericin b is combined with nisoldipine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PERHEXILINE is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "etizolam", "drug2": "Propoxycaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with Propoxycaine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "tolmetin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with tolmetin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nabumetone is combined with haloperidol.", "severity": 2}
{"drug1": "naratriptan", "drug2": "thioridazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with thioridazine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Lorcaserin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Vilazodone is combined with Lorcaserin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Ethylmorphine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "propranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when minoxidil is combined with propranolol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with Fencamfamin.", "severity": 2}
{"drug1": "prazepam", "drug2": "dantrolene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazepam is combined with dantrolene.", "severity": 2}
{"drug1": "irbesartan", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irbesartan is combined with quinapril.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "efavirenz", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amitriptyline is combined with efavirenz.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Pizotifen.", "severity": 2}
{"drug1": "ethanol", "drug2": "bupropion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with bupropion.", "severity": 2}
{"drug1": "loxapine", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Pipotiazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tizanidine is combined with Pipotiazine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "NICORANDIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Halobetasol is combined with NICORANDIL.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxorubicin is combined with atorvastatin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Eplerenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with Eplerenone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with Aceprometazine.", "severity": 2}
{"drug1": "CHLOROPROCAINE", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CHLOROPROCAINE is combined with KETAZOLAM.", "severity": 2}
{"drug1": "celecoxib", "drug2": "equilin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when celecoxib is combined with equilin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Clobetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ADAPALENE is combined with Clobetasone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "prednisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diflunisal is combined with prednisone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Fospropofol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ethotoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nortriptyline is combined with ethotoin.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEXKETOPROFEN is combined with furosemide.", "severity": 2}
{"drug1": "quinidine", "drug2": "Pentolinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinidine is combined with Pentolinium.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with MOLINDONE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DIHYDROCODEINE is combined with Iloperidone.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "tretinoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nilvadipine is combined with tretinoin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when haloperidol is combined with thiamylal.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tranylcypromine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with tranylcypromine.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Carbetocin is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acebutolol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "captopril", "drug2": "CLONIXIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when captopril is combined with CLONIXIN.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "deslanoside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methyclothiazide is combined with deslanoside.", "severity": 2}
{"drug1": "leflunomide", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when leflunomide is combined with acemetacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Risedronic acid.", "severity": 2}
{"drug1": "promazine", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promazine is combined with bromazepam.", "severity": 2}
{"drug1": "promethazine", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with CYCLIZINE.", "severity": 2}
{"drug1": "promethazine", "drug2": "moclobemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when promethazine is combined with moclobemide.", "severity": 2}
{"drug1": "biperiden", "drug2": "tolterodine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when biperiden is combined with tolterodine.", "severity": 2}
{"drug1": "etizolam", "drug2": "chlorpheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with chlorpheniramine.", "severity": 2}
{"drug1": "propofol", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Fencamfamin.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Normethadone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Normethadone.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methoxyflurane is combined with etizolam.", "severity": 2}
{"drug1": "lisinopril", "drug2": "chloroquine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with chloroquine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isavuconazonium is combined with atorvastatin.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Ephedrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with Ephedrine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "PROCATEROL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with PROCATEROL.", "severity": 2}
{"drug1": "trandolapril", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trandolapril is combined with indapamide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "sulindac", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with sulindac.", "severity": 2}
{"drug1": "Butethal", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with clemastine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "thiopental", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with thiopental.", "severity": 2}
{"drug1": "Butethal", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Butethal is combined with venlafaxine.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Etidocaine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Coenzyme Q10", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilnidipine is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Articaine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with Pizotifen.", "severity": 2}
{"drug1": "propofol", "drug2": "Ethylmorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with Ethylmorphine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with Ramelteon.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Drospirenone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when levorphanol is combined with Drospirenone.", "severity": 2}
{"drug1": "tioconazole", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tioconazole is combined with atorvastatin.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "meclizine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meclizine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "droperidol", "drug2": "metoclopramide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when droperidol is combined with metoclopramide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "nefazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MORICIZINE is combined with nefazodone.", "severity": 2}
{"drug1": "reserpine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with etizolam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when METHOHEXITAL is combined with METAXALONE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fexofenadine is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "morphine", "drug2": "penbutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with penbutolol.", "severity": 2}
{"drug1": "ethotoin", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethotoin is combined with desipramine.", "severity": 2}
{"drug1": "morphine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Hexobarbital.", "severity": 2}
{"drug1": "morphine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with lithium ion.", "severity": 2}
{"drug1": "morphine", "drug2": "amobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with amobarbital.", "severity": 2}
{"drug1": "morphine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Butethal.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "furosemide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when SUFENTANIL is combined with furosemide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Bambuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Bambuterol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "salicylic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloroquine is combined with salicylic acid.", "severity": 2}
{"drug1": "etizolam", "drug2": "carisoprodol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etizolam is combined with carisoprodol.", "severity": 2}
{"drug1": "lorazepam", "drug2": "zotepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lorazepam is combined with zotepine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Levomepromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with Levomepromazine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "dihydrotachysterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Paricalcitol is combined with dihydrotachysterol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "nilvadipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with nilvadipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "clenbuterol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rasagiline is combined with clenbuterol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "enflurane", "drug2": "desipramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with desipramine.", "severity": 2}
{"drug1": "terconazole", "drug2": "Rosuvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when terconazole is combined with Rosuvastatin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "carvedilol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with carvedilol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "nalbuphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with nalbuphine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitroglycerin is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "formestane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lornoxicam is combined with formestane.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Fospropofol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nalbuphine is combined with Fospropofol.", "severity": 2}
{"drug1": "triamterene", "drug2": "trandolapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triamterene is combined with trandolapril.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Etidocaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Etidocaine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "papaverine", "drug2": "acebutolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when papaverine is combined with acebutolol.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "isoetharine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with isoetharine.", "severity": 2}
{"drug1": "metolazone", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with labetalol.", "severity": 2}
{"drug1": "baclofen", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when baclofen is combined with scopolamine.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "meclizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fluspirilene is combined with meclizine.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with oxprenolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ILOPROST is combined with nitric oxide.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "Ramelteon", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with Ramelteon.", "severity": 2}
{"drug1": "metolazone", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when metolazone is combined with doxazosin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "bromazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with bromazepam.", "severity": 2}
{"drug1": "chlormezanone", "drug2": "DIMENHYDRINATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlormezanone is combined with DIMENHYDRINATE.", "severity": 2}
{"drug1": "citric acid", "drug2": "Deferasirox", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when citric acid is combined with Deferasirox.", "severity": 2}
{"drug1": "chloral hydrate", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chloral hydrate is combined with prazepam.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "butalbital", "drug2": "Desloratadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butalbital is combined with Desloratadine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorothiazide is combined with Riociguat.", "severity": 2}
{"drug1": "cilazapril", "drug2": "PIRFENIDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilazapril is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Aceprometazine is combined with Pipamperone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "risperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when LISURIDE is combined with risperidone.", "severity": 2}
{"drug1": "codeine", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with levorphanol.", "severity": 2}
{"drug1": "enflurane", "drug2": "trazodone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with trazodone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "mecamylamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clomipramine is combined with mecamylamine.", "severity": 2}
{"drug1": "triprolidine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triprolidine is combined with sertraline.", "severity": 2}
{"drug1": "dyclonine", "drug2": "glutethimide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dyclonine is combined with glutethimide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Frovatriptan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with Frovatriptan.", "severity": 2}
{"drug1": "sulpiride", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with tetracaine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaleplon is combined with Perospirone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rapamycin is combined with leflunomide.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thalidomide is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "reserpine", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with KETAZOLAM.", "severity": 2}
{"drug1": "nimesulide", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nimesulide is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Candesartan cilexetil", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "tolazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TAMSULOSIN is combined with tolazoline.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlorthalidone is combined with nicardipine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "hydrocortisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when mefenamic acid is combined with hydrocortisone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "benazepril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ropinirole is combined with benazepril.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Butethal.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Hexobarbital.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "lithium ion", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with lithium ion.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "etizolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with etizolam.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "Lormetazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxetacaine is combined with Lormetazepam.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "isocarboxazid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zolmitriptan is combined with isocarboxazid.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lisinopril is combined with Empagliflozin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "VORTIOXETINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isocarboxazid is combined with Pipamperone.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "phenytoin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with phenytoin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "pramipexole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amiodarone is combined with pramipexole.", "severity": 2}
{"drug1": "pramipexole", "drug2": "ropinirole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with ropinirole.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Fencamfamin is combined with Olopatadine.", "severity": 2}
{"drug1": "glutethimide", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with MELPERONE.", "severity": 2}
{"drug1": "pramipexole", "drug2": "metoprolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pramipexole is combined with metoprolol.", "severity": 2}
{"drug1": "oxycodone", "drug2": "ethyl loflazepate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with ethyl loflazepate.", "severity": 2}
{"drug1": "oxycodone", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxycodone is combined with flunitrazepam.", "severity": 2}
{"drug1": "proparacaine", "drug2": "methoxyflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when proparacaine is combined with methoxyflurane.", "severity": 2}
{"drug1": "amobarbital", "drug2": "HEROIN", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when amobarbital is combined with HEROIN.", "severity": 2}
{"drug1": "sertraline", "drug2": "ACETOPHENAZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sertraline is combined with ACETOPHENAZINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with tiapride.", "severity": 2}
{"drug1": "quetiapine", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quetiapine is combined with triflupromazine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "edrophonium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurandrenolide is combined with edrophonium.", "severity": 2}
{"drug1": "carprofen", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carprofen is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Butethal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Butethal.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "gabapentin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with gabapentin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Hexobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ondansetron is combined with Hexobarbital.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Risedronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tiaprofenic acid is combined with Risedronic acid.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "pravastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MAGNESIUM SULFATE is combined with pravastatin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "tiapride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Milnacipran is combined with tiapride.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Escitalopram", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dothiepin is combined with Escitalopram.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "amisulpride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dihydroergotamine is combined with amisulpride.", "severity": 2}
{"drug1": "bromazepam", "drug2": "flunarizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bromazepam is combined with flunarizine.", "severity": 2}
{"drug1": "nicergoline", "drug2": "danazol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nicergoline is combined with danazol.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Metipranolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with Metipranolol.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when D-mannitol is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "bepridil", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with Bortezomib.", "severity": 2}
{"drug1": "bepridil", "drug2": "ESMOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bepridil is combined with ESMOLOL.", "severity": 2}
{"drug1": "labetalol", "drug2": "ritodrine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when labetalol is combined with ritodrine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Lofexidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Bortezomib is combined with Lofexidine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "MELPERONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with MELPERONE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Ibandronic Acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Icatibant is combined with Ibandronic Acid.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Pizotifen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when perphenazine is combined with Pizotifen.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "ethosuximide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with ethosuximide.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Isoconazole is combined with nimesulide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "betaxolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with betaxolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "pancuronium", "drug2": "ALFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pancuronium is combined with ALFENTANIL.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Pefloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when FLUTICASONE PROPIONATE is combined with Pefloxacin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when BENZYDAMINE is combined with haloperidol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Gatifloxacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with Gatifloxacin.", "severity": 2}
{"drug1": "dibucaine", "drug2": "flunitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dibucaine is combined with flunitrazepam.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "methacholine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rivastigmine is combined with methacholine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "memantine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CORTISONE ACETATE is combined with memantine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "METAXALONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with METAXALONE.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "irbesartan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with irbesartan.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Metixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxybutynin is combined with Metixene.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "felodipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when dipyridamole is combined with felodipine.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "eperisone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 5-Fluorocytosine is combined with eperisone.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nelfinavir is combined with meperidine.", "severity": 2}
{"drug1": "Metixene", "drug2": "Methadyl acetate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metixene is combined with Methadyl acetate.", "severity": 2}
{"drug1": "Pramocaine", "drug2": "Oxetacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Pramocaine is combined with Oxetacaine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "triamcinolone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when zaltoprofen is combined with triamcinolone.", "severity": 2}
{"drug1": "HEROIN", "drug2": "KETAZOLAM", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with KETAZOLAM.", "severity": 2}
{"drug1": "halothane", "drug2": "ramipril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when halothane is combined with ramipril.", "severity": 2}
{"drug1": "meperidine", "drug2": "propoxyphene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when meperidine is combined with propoxyphene.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Flupentixol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with Flupentixol.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MELPERONE is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "terbutaline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Phenelzine is combined with terbutaline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Bortezomib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when apomorphine is combined with Bortezomib.", "severity": 2}
{"drug1": "etodolac", "drug2": "medrysone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with medrysone.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "nimesulide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when rescinnamine is combined with nimesulide.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "felbamate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with felbamate.", "severity": 2}
{"drug1": "Lormetazepam", "drug2": "duloxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lormetazepam is combined with duloxetine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with indapamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "Empagliflozin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with Empagliflozin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "proparacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with proparacaine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when HEROIN is combined with oxprenolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Halazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with Halazepam.", "severity": 2}
{"drug1": "morniflumate", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with carprofen.", "severity": 2}
{"drug1": "valsartan", "drug2": "sotalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when valsartan is combined with sotalol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Ketobemidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Asenapine is combined with Ketobemidone.", "severity": 2}
{"drug1": "gabapentin", "drug2": "CYCLIZINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when gabapentin is combined with CYCLIZINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with cilazapril.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Fluprednidene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ZILEUTON is combined with Fluprednidene.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "oxprenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with oxprenolol.", "severity": 2}
{"drug1": "morphine", "drug2": "Aliskiren", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with Aliskiren.", "severity": 2}
{"drug1": "betaxolol", "drug2": "pilocarpine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when betaxolol is combined with pilocarpine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "Aceprometazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with Aceprometazine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "DESONIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when acemetacin is combined with DESONIDE.", "severity": 2}
{"drug1": "risperidone", "drug2": "nitrazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with nitrazepam.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Nitroprusside", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Torasemide is combined with Nitroprusside.", "severity": 2}
{"drug1": "prilocaine", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with sertraline.", "severity": 2}
{"drug1": "fosinopril", "drug2": "resveratrol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with resveratrol.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "isoxsuprine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PROCATEROL is combined with isoxsuprine.", "severity": 2}
{"drug1": "4-Hydroxybutanoic acid", "drug2": "Asenapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when 4-Hydroxybutanoic acid is combined with Asenapine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nadolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when arsenic trioxide is combined with nadolol.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Clevidipine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "estrone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with estrone.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flurazepam is combined with Iloperidone.", "severity": 2}
{"drug1": "clozapine", "drug2": "thiamylal", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with thiamylal.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when naratriptan is combined with Paliperidone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Remoxipride.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Remoxipride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Remoxipride.", "severity": 2}
{"drug1": "propofol", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when propofol is combined with chloral hydrate.", "severity": 2}
{"drug1": "diclofenac", "drug2": "CLOCORTOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diclofenac is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "levorphanol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when UMECLIDINIUM is combined with levorphanol.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with nisoldipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "DEXMEDETOMIDINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when fosinopril is combined with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Dexbrompheniramine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with Dexbrompheniramine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Demecarium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when PREDNICARBATE is combined with Demecarium.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrazepam is combined with Retigabine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "fluocinonide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Loxoprofen is combined with fluocinonide.", "severity": 2}
{"drug1": "etodolac", "drug2": "suprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with suprofen.", "severity": 2}
{"drug1": "etodolac", "drug2": "loteprednol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with loteprednol.", "severity": 2}
{"drug1": "temazepam", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with levodopa.", "severity": 2}
{"drug1": "temazepam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with sevoflurane.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzyl alcohol is combined with Retigabine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentobarbital is combined with Retigabine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Clevidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Metipranolol is combined with Clevidipine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "digoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with digoxin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "sulpiride", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when QUINETHAZONE is combined with sulpiride.", "severity": 2}
{"drug1": "Trospium", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Trospium is combined with meperidine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Paliperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rufinamide is combined with Paliperidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DEZOCINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with DEZOCINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "leflunomide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with leflunomide.", "severity": 2}
{"drug1": "temazepam", "drug2": "amoxapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when temazepam is combined with amoxapine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "triflupromazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when VALPROIC ACID is combined with triflupromazine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when REMIFENTANIL is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Levetiracetam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carbamazepine is combined with Levetiracetam.", "severity": 2}
{"drug1": "loxapine", "drug2": "ketamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with ketamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Articaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with Articaine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "tizanidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with tizanidine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "acemetacin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulfasalazine is combined with acemetacin.", "severity": 2}
{"drug1": "indapamide", "drug2": "acetyldigitoxin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indapamide is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "ipratropium", "drug2": "buprenorphine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ipratropium is combined with buprenorphine.", "severity": 2}
{"drug1": "enflurane", "drug2": "Mephobarbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when enflurane is combined with Mephobarbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "zonisamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with zonisamide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cilostazol is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "niflumic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when antipyrine is combined with niflumic acid.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ETHACRYNIC ACID", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Articaine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Articaine is combined with paroxetine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Levomilnacipran", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when flunitrazepam is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tramadol", "drug2": "tiagabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tramadol is combined with tiagabine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when chlordiazepoxide is combined with MOLINDONE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when diltiazem is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "risperidone", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when risperidone is combined with butalbital.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "fludiazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with fludiazepam.", "severity": 2}
{"drug1": "methylene blue", "drug2": "hydromorphone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylene blue is combined with hydromorphone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "chloral hydrate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when trifluoperazine is combined with chloral hydrate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tetracaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when lithium ion is combined with tetracaine.", "severity": 2}
{"drug1": "isradipine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when isradipine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "codeine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ATROPINE is combined with codeine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Carbetocin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with Carbetocin.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nitrous oxide is combined with Iloperidone.", "severity": 2}
{"drug1": "epirizole", "drug2": "flumethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epirizole is combined with flumethasone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with prazepam.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Tedizolid phosphate is combined with clozapine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when methylergonovine is combined with nitric oxide.", "severity": 2}
{"drug1": "butabarbital", "drug2": "quazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with quazepam.", "severity": 2}
{"drug1": "butabarbital", "drug2": "prazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with prazepam.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "doxazosin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with doxazosin.", "severity": 2}
{"drug1": "ketamine", "drug2": "clonidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ketamine is combined with clonidine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "indapamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Rotigotine is combined with indapamide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "REMIFENTANIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when MOXONIDINE is combined with REMIFENTANIL.", "severity": 2}
{"drug1": "morphine", "drug2": "oxazepam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morphine is combined with oxazepam.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "RIMEXOLONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "morniflumate", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when morniflumate is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "codeine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with levodopa.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Ropivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with Ropivacaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "bupivacaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when oxazepam is combined with bupivacaine.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when KETAZOLAM is combined with MOLINDONE.", "severity": 2}
{"drug1": "benzocaine", "drug2": "levodopa", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when benzocaine is combined with levodopa.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Methylnaltrexone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Methylnaltrexone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "BALSALAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when AZILSARTAN MEDOXOMIL is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "prilocaine", "drug2": "Olopatadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prilocaine is combined with Olopatadine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "pimozide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with pimozide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "sertraline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Almotriptan is combined with sertraline.", "severity": 2}
{"drug1": "sulpiride", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sulpiride is combined with fexofenadine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Lumiracoxib", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ibuprofen is combined with Lumiracoxib.", "severity": 2}
{"drug1": "codeine", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when codeine is combined with Aripiprazole.", "severity": 2}
{"drug1": "linezolid", "drug2": "bromocriptine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when linezolid is combined with bromocriptine.", "severity": 2}
{"drug1": "pergolide", "drug2": "CORTISONE ACETATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pergolide is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "hydralazine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when nisoldipine is combined with hydralazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "QUINETHAZONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Fencamfamin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with Fencamfamin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "clozapine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when irinotecan is combined with clozapine.", "severity": 2}
{"drug1": "THYMOL", "drug2": "nisoldipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when THYMOL is combined with nisoldipine.", "severity": 2}
{"drug1": "Oxybuprocaine", "drug2": "scopolamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with scopolamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "polythiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ALFENTANIL is combined with polythiazide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "midazolam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eszopiclone is combined with midazolam.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Propacetamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with Propacetamol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "quinapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with quinapril.", "severity": 2}
{"drug1": "loxapine", "drug2": "fluvoxamine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when loxapine is combined with fluvoxamine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "BREXPIPRAZOLE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when maprotiline is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Hexobarbital is combined with baclofen.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "bumetanide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when bupivacaine is combined with bumetanide.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "atenolol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with atenolol.", "severity": 2}
{"drug1": "glutethimide", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with venlafaxine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Pimecrolimus", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with Pimecrolimus.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Methylscopolamine bromide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolterodine is combined with Methylscopolamine bromide.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "lovastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Azelnidipine is combined with lovastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "MOLINDONE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triazolam is combined with MOLINDONE.", "severity": 2}
{"drug1": "glutethimide", "drug2": "clemastine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when glutethimide is combined with clemastine.", "severity": 2}
{"drug1": "midazolam", "drug2": "fexofenadine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when midazolam is combined with fexofenadine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Lercanidipine is combined with AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "hydrochlorothiazide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CARTEOLOL is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with maprotiline.", "severity": 2}
{"drug1": "butabarbital", "drug2": "baclofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with baclofen.", "severity": 2}
{"drug1": "ramipril", "drug2": "Lornoxicam", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ramipril is combined with Lornoxicam.", "severity": 2}
{"drug1": "doxylamine", "drug2": "paroxetine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when doxylamine is combined with paroxetine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "clidinium", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when triflupromazine is combined with clidinium.", "severity": 2}
{"drug1": "butabarbital", "drug2": "ethchlorvynol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butabarbital is combined with ethchlorvynol.", "severity": 2}
{"drug1": "prazosin", "drug2": "nicardipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when prazosin is combined with nicardipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "cilazapril", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when reserpine is combined with cilazapril.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "MOEXIPRIL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Clofarabine is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "LEVOBUNOLOL", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DESFLURANE is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "pentazocine", "drug2": "procaine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when pentazocine is combined with procaine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "dipivefrin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Toloxatone is combined with dipivefrin.", "severity": 2}
{"drug1": "clozapine", "drug2": "CYPROHEPTADINE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with CYPROHEPTADINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "nitric oxide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with nitric oxide.", "severity": 2}
{"drug1": "clozapine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when clozapine is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Lercanidipine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Caspofungin is combined with Lercanidipine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Riociguat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nebivolol is combined with Riociguat.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "carprofen", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Nepafenac is combined with carprofen.", "severity": 2}
{"drug1": "butamben", "drug2": "Levocetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when butamben is combined with Levocetirizine.", "severity": 2}
{"drug1": "ethanol", "drug2": "venlafaxine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethanol is combined with venlafaxine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Aripiprazole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with Aripiprazole.", "severity": 2}
{"drug1": "estazolam", "drug2": "chlorprothixene", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with chlorprothixene.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "DIPHENOXYLATE", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Atracurium besylate is combined with DIPHENOXYLATE.", "severity": 2}
{"drug1": "estazolam", "drug2": "sevoflurane", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when estazolam is combined with sevoflurane.", "severity": 2}
{"drug1": "floctafenine", "drug2": "dexamethasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when floctafenine is combined with dexamethasone.", "severity": 2}
{"drug1": "quinapril", "drug2": "Pregabalin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with Pregabalin.", "severity": 2}
{"drug1": "epinephrine", "drug2": "oxymetazoline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when epinephrine is combined with oxymetazoline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thioridazine is combined with butalbital.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "primidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with primidone.", "severity": 2}
{"drug1": "etodolac", "drug2": "Magnesium salicylate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Iloperidone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when TRICHLOROETHYLENE is combined with Iloperidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Perospirone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when thiopental is combined with Perospirone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Etidronic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with Etidronic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "atorvastatin", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tolfenamic acid is combined with atorvastatin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Salsalate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when etodolac is combined with Salsalate.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "labetalol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Sacubitril is combined with labetalol.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "desoximetasone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when tenoxicam is combined with desoximetasone.", "severity": 2}
{"drug1": "Limaprost", "drug2": "EDTA", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with EDTA.", "severity": 2}
{"drug1": "Limaprost", "drug2": "dipyridamole", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Limaprost is combined with dipyridamole.", "severity": 2}
{"drug1": "Apremilast", "drug2": "haloperidol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Apremilast is combined with haloperidol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "pirenzepine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with pirenzepine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "methocarbamol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with methocarbamol.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when scopolamine is combined with Retigabine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Enalaprilat", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Eprosartan is combined with Enalaprilat.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Pipamperone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when sevoflurane is combined with Pipamperone.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Tapentadol", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Propiverine is combined with Tapentadol.", "severity": 2}
{"drug1": "quinapril", "drug2": "salicylamide", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when quinapril is combined with salicylamide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "mefenamic acid", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when indomethacin is combined with mefenamic acid.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "cetirizine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Ziprasidone is combined with cetirizine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "methylphenidate", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with methylphenidate.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "butalbital", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclobenzaprine is combined with butalbital.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Remoxipride is combined with triprolidine.", "severity": 2}
{"drug1": "ethyl loflazepate", "drug2": "maprotiline", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when ethyl loflazepate is combined with maprotiline.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Retigabine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when carisoprodol is combined with Retigabine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "meperidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when cyclopentolate is combined with meperidine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with spironolactone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "irinotecan", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when CABAZITAXEL is combined with irinotecan.", "severity": 2}
{"drug1": "phentolamine", "drug2": "spironolactone", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when phentolamine is combined with spironolactone.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Apixaban", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when Triflusal is combined with Apixaban.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "triprolidine", "interaction_type": 49, "interaction_text": "The risk or severity of adverse effects can be increased when DEZOCINE is combined with triprolidine.", "severity": 2}
{"drug1": "voglibose", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with voglibose.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with tolbutamide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Canagliflozin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Alogliptin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with nateglinide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Sitagliptin.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Empagliflozin.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Pioglitazone.", "severity": 2}
{"drug1": "glyburide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with glyburide.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Vildagliptin.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with MIGLITOL.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with gliclazide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Saxagliptin.", "severity": 2}
{"drug1": "acarbose", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with acarbose.", "severity": 2}
{"drug1": "metformin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with metformin.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with tolazamide.", "severity": 2}
{"drug1": "Miglustat", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Miglustat.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Repaglinide.", "severity": 2}
{"drug1": "glipizide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with glipizide.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Gliquidone.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with Linagliptin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with chlorpropamide.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with glimepiride.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Pregabalin", "interaction_type": 50, "interaction_text": "The risk or severity of heart failure can be increased when Pregabalin is combined with rosiglitazone.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "trichlormethiazide", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "methyclothiazide", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of methyclothiazide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "polythiazide", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of polythiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "chlorthalidone", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "hydrochlorothiazide", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "polythiazide", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of polythiazide.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "hydroflumethiazide", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "hydroflumethiazide", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "chlorothiazide", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "indapamide", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of indapamide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "QUINETHAZONE", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "danazol", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of danazol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "hydroflumethiazide", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "trichlormethiazide", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "chlorothiazide", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of chlorothiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "QUINETHAZONE", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "toremifene", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "QUINETHAZONE", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "QUINETHAZONE", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "hydroflumethiazide", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "metolazone", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of metolazone.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "indapamide", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of indapamide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "danazol", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of danazol.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "trichlormethiazide", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "methyclothiazide", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "hydrochlorothiazide", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "chlorothiazide", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "chlorthalidone", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "methyclothiazide", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "polythiazide", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of polythiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "QUINETHAZONE", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "hydroflumethiazide", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "trichlormethiazide", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "chlorthalidone", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "polythiazide", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of polythiazide.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "QUINETHAZONE", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "danazol", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of danazol.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "danazol", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of danazol.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "methyclothiazide", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "hydrochlorothiazide", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "chlorthalidone", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of chlorthalidone.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "chlorothiazide", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "indapamide", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of indapamide.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "chlorothiazide", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "hydroflumethiazide", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "danazol", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of danazol.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "trichlormethiazide", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "indapamide", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of indapamide.", "severity": 2}
{"drug1": "toremifene", "drug2": "hydrochlorothiazide", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "hydrochlorothiazide", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "chlorthalidone", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "hydrochlorothiazide", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "chlorthalidone", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of chlorthalidone.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "indapamide", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of indapamide.", "severity": 2}
{"drug1": "toremifene", "drug2": "hydroflumethiazide", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "metolazone", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of metolazone.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "polythiazide", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of polythiazide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "methyclothiazide", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "metolazone", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of metolazone.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "danazol", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of danazol.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "metolazone", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of metolazone.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "metolazone", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of metolazone.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "methyclothiazide", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "indapamide", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of indapamide.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "metolazone", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of metolazone.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "QUINETHAZONE", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "chlorthalidone", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "chlorothiazide", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "hydrochlorothiazide", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Calcifediol", "drug2": "metolazone", "interaction_type": 51, "interaction_text": "Calcifediol may increase the hypercalcemic activities of metolazone.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "chlorothiazide", "interaction_type": 51, "interaction_text": "ergocalciferol may increase the hypercalcemic activities of chlorothiazide.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dihydrotachysterol", "drug2": "polythiazide", "interaction_type": 51, "interaction_text": "dihydrotachysterol may increase the hypercalcemic activities of polythiazide.", "severity": 2}
{"drug1": "Calcipotriol", "drug2": "trichlormethiazide", "interaction_type": 51, "interaction_text": "Calcipotriol may increase the hypercalcemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "polythiazide", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of polythiazide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "indapamide", "interaction_type": 51, "interaction_text": "Paricalcitol may increase the hypercalcemic activities of indapamide.", "severity": 2}
{"drug1": "Doxercalciferol", "drug2": "trichlormethiazide", "interaction_type": 51, "interaction_text": "Doxercalciferol may increase the hypercalcemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "methyclothiazide", "interaction_type": 51, "interaction_text": "toremifene may increase the hypercalcemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Palonosetron", "interaction_type": 52, "interaction_text": "Tapentadol may decrease the analgesic activities of Palonosetron.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ondansetron", "interaction_type": 52, "interaction_text": "Tramadol may decrease the analgesic activities of ondansetron.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "tropisetron", "interaction_type": 52, "interaction_text": "Tapentadol may decrease the analgesic activities of tropisetron.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "granisetron", "interaction_type": 52, "interaction_text": "Tapentadol may decrease the analgesic activities of granisetron.", "severity": 2}
{"drug1": "Tramadol", "drug2": "granisetron", "interaction_type": 52, "interaction_text": "Tramadol may decrease the analgesic activities of granisetron.", "severity": 2}
{"drug1": "Tramadol", "drug2": "tropisetron", "interaction_type": 52, "interaction_text": "Tramadol may decrease the analgesic activities of tropisetron.", "severity": 2}
{"drug1": "Tramadol", "drug2": "dolasetron", "interaction_type": 52, "interaction_text": "Tramadol may decrease the analgesic activities of dolasetron.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "quinidine", "interaction_type": 52, "interaction_text": "DIHYDROCODEINE may decrease the analgesic activities of quinidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Palonosetron", "interaction_type": 52, "interaction_text": "Tramadol may decrease the analgesic activities of Palonosetron.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "dolasetron", "interaction_type": 52, "interaction_text": "Tapentadol may decrease the analgesic activities of dolasetron.", "severity": 2}
{"drug1": "celecoxib", "drug2": "venlafaxine", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of venlafaxine.", "severity": 2}
{"drug1": "tirofiban", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "tirofiban may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "Cangrelor may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "ibudilast", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of ibudilast.", "severity": 2}
{"drug1": "ibudilast", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "Cangrelor may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "citalopram", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of citalopram.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "trapidil", "drug2": "azelastine", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of azelastine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "Ticagrelor may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Levomilnacipran", "interaction_type": 53, "interaction_text": "Etoricoxib may increase the antiplatelet activities of Levomilnacipran.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "dipyridamole may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "alprostadil", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of alprostadil.", "severity": 2}
{"drug1": "anagrelide", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "anagrelide may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "nefazodone", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of nefazodone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "alprostadil", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of alprostadil.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "ticlopidine may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "trapidil", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "milrinone", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "milrinone may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "dipyridamole may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "azelastine", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of azelastine.", "severity": 2}
{"drug1": "aspirin", "drug2": "paroxetine", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of paroxetine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "cilostazol may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "Cangrelor may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "epinastine", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Levomilnacipran", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of Levomilnacipran.", "severity": 2}
{"drug1": "azelastine", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "alprostadil", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "clopidogrel may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "anagrelide may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "sevoflurane", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of sevoflurane.", "severity": 2}
{"drug1": "alprostadil", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "anagrelide", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "anagrelide may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "paroxetine", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of paroxetine.", "severity": 2}
{"drug1": "milrinone", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "milrinone may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "alprostadil", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "alprostadil", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of alprostadil.", "severity": 2}
{"drug1": "etodolac", "drug2": "sertraline", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of sertraline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "sertraline", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of sertraline.", "severity": 2}
{"drug1": "ibudilast", "drug2": "alprostadil", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of alprostadil.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "ILOPROST may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "aspirin", "drug2": "Escitalopram", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of Escitalopram.", "severity": 2}
{"drug1": "aspirin", "drug2": "duloxetine", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of duloxetine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "aspirin", "drug2": "fluoxetine", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of fluoxetine.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "aspirin", "drug2": "Levomilnacipran", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of Levomilnacipran.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "Prasugrel may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "resveratrol", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "resveratrol", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "Triflusal", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "Triflusal may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "Cangrelor may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "etodolac", "drug2": "duloxetine", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of duloxetine.", "severity": 2}
{"drug1": "aspirin", "drug2": "fluvoxamine", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of fluvoxamine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "nimesulide", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of nimesulide.", "severity": 2}
{"drug1": "epinastine", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "cilostazol", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "cilostazol may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "nimesulide", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "etodolac", "drug2": "fluvoxamine", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of fluvoxamine.", "severity": 2}
{"drug1": "ibudilast", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "etodolac", "drug2": "fluoxetine", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of fluoxetine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "cilostazol may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "alprostadil", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "pentoxifylline may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "azelastine", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "epinastine", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "Triflusal may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Escitalopram", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of Escitalopram.", "severity": 2}
{"drug1": "nabumetone", "drug2": "nefazodone", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of nefazodone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "trapidil", "drug2": "ethyl icosapentate", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of ethyl icosapentate.", "severity": 2}
{"drug1": "etodolac", "drug2": "venlafaxine", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of venlafaxine.", "severity": 2}
{"drug1": "epinastine", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "resveratrol", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "pentoxifylline may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "milrinone", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "milrinone may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "resveratrol", "drug2": "sevoflurane", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of sevoflurane.", "severity": 2}
{"drug1": "ibudilast", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Levomilnacipran", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of Levomilnacipran.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "ibudilast", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of ibudilast.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "aspirin", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "ticlopidine may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "nimesulide", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of nimesulide.", "severity": 2}
{"drug1": "epinastine", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "ILOPROST may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "tirofiban", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "tirofiban may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "ticlopidine may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "etodolac", "drug2": "citalopram", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of citalopram.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "duloxetine", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of duloxetine.", "severity": 2}
{"drug1": "trapidil", "drug2": "alprostadil", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of alprostadil.", "severity": 2}
{"drug1": "aspirin", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Milnacipran", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of Milnacipran.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "fluoxetine", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of fluoxetine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Escitalopram", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of Escitalopram.", "severity": 2}
{"drug1": "nabumetone", "drug2": "sertraline", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of sertraline.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "ibudilast", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "resveratrol", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of resveratrol.", "severity": 2}
{"drug1": "ibudilast", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "citalopram", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of citalopram.", "severity": 2}
{"drug1": "trapidil", "drug2": "ibudilast", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of ibudilast.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "Prasugrel may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "venlafaxine", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of venlafaxine.", "severity": 2}
{"drug1": "argatroban", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "argatroban may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "anagrelide may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "milrinone", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "milrinone may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "trapidil", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "epoprostenol may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "trapidil", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Milnacipran", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of Milnacipran.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "Vorapaxar may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "aspirin", "drug2": "nefazodone", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of nefazodone.", "severity": 2}
{"drug1": "trapidil", "drug2": "Ifenprodil", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of Ifenprodil.", "severity": 2}
{"drug1": "ibudilast", "drug2": "resveratrol", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of resveratrol.", "severity": 2}
{"drug1": "alprostadil", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "trapidil", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "ticlopidine may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "aspirin", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "citalopram", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of citalopram.", "severity": 2}
{"drug1": "ibudilast", "drug2": "sevoflurane", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of sevoflurane.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "sevoflurane", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of sevoflurane.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "epoprostenol may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "azelastine", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "duloxetine", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of duloxetine.", "severity": 2}
{"drug1": "tirofiban", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "tirofiban may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "resveratrol", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "Ticagrelor may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "sertraline", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of sertraline.", "severity": 2}
{"drug1": "ibudilast", "drug2": "azelastine", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "Vorapaxar may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "sevoflurane", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of sevoflurane.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "venlafaxine", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of venlafaxine.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "ethyl icosapentate", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of ethyl icosapentate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "duloxetine", "interaction_type": 53, "interaction_text": "Etoricoxib may increase the antiplatelet activities of duloxetine.", "severity": 2}
{"drug1": "trapidil", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "trapidil", "drug2": "resveratrol", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of resveratrol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "ticlopidine may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "Vorapaxar may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "epinastine", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "nimesulide", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "tirofiban", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "tirofiban may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "ibudilast", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "Prasugrel may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "epinastine", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "azelastine", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "Triflusal", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "Triflusal may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "argatroban", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "argatroban may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "ibudilast", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "trapidil", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "trapidil", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "Cangrelor may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "epoprostenol may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "epoprostenol may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Levomilnacipran", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of Levomilnacipran.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "dipyridamole may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "epinastine", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "epinastine may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "trapidil", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "Vorapaxar may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "Prasugrel may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "trapidil", "drug2": "sevoflurane", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of sevoflurane.", "severity": 2}
{"drug1": "ibudilast", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Milnacipran", "interaction_type": 53, "interaction_text": "Lumiracoxib may increase the antiplatelet activities of Milnacipran.", "severity": 2}
{"drug1": "aspirin", "drug2": "sertraline", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of sertraline.", "severity": 2}
{"drug1": "Triflusal", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "Triflusal may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "alprostadil", "drug2": "milrinone", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of milrinone.", "severity": 2}
{"drug1": "alprostadil", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "clopidogrel may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Escitalopram", "interaction_type": 53, "interaction_text": "Etoricoxib may increase the antiplatelet activities of Escitalopram.", "severity": 2}
{"drug1": "azelastine", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "etodolac", "drug2": "nefazodone", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of nefazodone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "anagrelide", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "anagrelide may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "tirofiban", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "tirofiban may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "venlafaxine", "interaction_type": 53, "interaction_text": "Etoricoxib may increase the antiplatelet activities of venlafaxine.", "severity": 2}
{"drug1": "aspirin", "drug2": "venlafaxine", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of venlafaxine.", "severity": 2}
{"drug1": "etodolac", "drug2": "Escitalopram", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of Escitalopram.", "severity": 2}
{"drug1": "tirofiban", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "tirofiban may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "etodolac", "drug2": "Levomilnacipran", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of Levomilnacipran.", "severity": 2}
{"drug1": "cilostazol", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "cilostazol may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "Prasugrel may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "ibudilast", "drug2": "nimesulide", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of nimesulide.", "severity": 2}
{"drug1": "azelastine", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "aspirin", "interaction_type": 53, "interaction_text": "Ticagrelor may increase the antiplatelet activities of aspirin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "Vorapaxar may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "pentoxifylline may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "dipyridamole may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "sevoflurane may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "clopidogrel may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "citalopram", "interaction_type": 53, "interaction_text": "Etoricoxib may increase the antiplatelet activities of citalopram.", "severity": 2}
{"drug1": "Triflusal", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "Triflusal may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "ILOPROST may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "Triflusal", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "Triflusal may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "sertraline", "interaction_type": 53, "interaction_text": "Etoricoxib may increase the antiplatelet activities of sertraline.", "severity": 2}
{"drug1": "argatroban", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "argatroban may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Escitalopram", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of Escitalopram.", "severity": 2}
{"drug1": "milrinone", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "milrinone may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "paroxetine", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of paroxetine.", "severity": 2}
{"drug1": "trapidil", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "argatroban", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "argatroban may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "argatroban", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "argatroban may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "nimesulide", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "milrinone", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "milrinone may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "milrinone", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "milrinone may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "cilostazol", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "cilostazol may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "Vorapaxar may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "etodolac", "drug2": "Milnacipran", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of Milnacipran.", "severity": 2}
{"drug1": "celecoxib", "drug2": "paroxetine", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of paroxetine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "duloxetine", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of duloxetine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "clopidogrel may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "clopidogrel may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fluoxetine", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of fluoxetine.", "severity": 2}
{"drug1": "etodolac", "drug2": "paroxetine", "interaction_type": 53, "interaction_text": "etodolac may increase the antiplatelet activities of paroxetine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "resveratrol may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "cilostazol may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "ticlopidine may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "epinastine", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of epinastine.", "severity": 2}
{"drug1": "ibudilast", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "ibudilast may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "ILOPROST may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "trapidil", "drug2": "nimesulide", "interaction_type": 53, "interaction_text": "trapidil may increase the antiplatelet activities of nimesulide.", "severity": 2}
{"drug1": "alprostadil", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Treprostinil", "interaction_type": 53, "interaction_text": "Prasugrel may increase the antiplatelet activities of Treprostinil.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "ILOPROST", "interaction_type": 53, "interaction_text": "clopidogrel may increase the antiplatelet activities of ILOPROST.", "severity": 2}
{"drug1": "nabumetone", "drug2": "fluoxetine", "interaction_type": 53, "interaction_text": "nabumetone may increase the antiplatelet activities of fluoxetine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Milnacipran", "interaction_type": 53, "interaction_text": "Etoricoxib may increase the antiplatelet activities of Milnacipran.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "glucosamine", "interaction_type": 53, "interaction_text": "Ticagrelor may increase the antiplatelet activities of glucosamine.", "severity": 2}
{"drug1": "alprostadil", "drug2": "pentoxifylline", "interaction_type": 53, "interaction_text": "alprostadil may increase the antiplatelet activities of pentoxifylline.", "severity": 2}
{"drug1": "aspirin", "drug2": "citalopram", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of citalopram.", "severity": 2}
{"drug1": "Cangrelor", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "Cangrelor may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "azelastine", "drug2": "Limaprost", "interaction_type": 53, "interaction_text": "azelastine may increase the antiplatelet activities of Limaprost.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "VITAMIN E", "interaction_type": 53, "interaction_text": "Ibrutinib may increase the antiplatelet activities of VITAMIN E.", "severity": 2}
{"drug1": "aspirin", "drug2": "Milnacipran", "interaction_type": 53, "interaction_text": "aspirin may increase the antiplatelet activities of Milnacipran.", "severity": 2}
{"drug1": "ethyl icosapentate", "drug2": "resveratrol", "interaction_type": 53, "interaction_text": "ethyl icosapentate may increase the antiplatelet activities of resveratrol.", "severity": 2}
{"drug1": "Ifenprodil", "drug2": "azelastine", "interaction_type": 53, "interaction_text": "Ifenprodil may increase the antiplatelet activities of azelastine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "epoprostenol", "interaction_type": 53, "interaction_text": "nimesulide may increase the antiplatelet activities of epoprostenol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fluvoxamine", "interaction_type": 53, "interaction_text": "celecoxib may increase the antiplatelet activities of fluvoxamine.", "severity": 2}
{"drug1": "digoxin", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "Octreotide", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "nadolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "labetalol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "alprenolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "nadolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "practolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Tapentadol", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of Tapentadol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "VERAPAMIL may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "memantine", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "memantine", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "amiodarone", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "timolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "malathion", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Dronedarone", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of Dronedarone.", "severity": 2}
{"drug1": "clonidine", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "practolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "propafenone", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "propafenone may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Octreotide", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "digoxin", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "practolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Octreotide", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Octreotide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "DEZOCINE", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of DEZOCINE.", "severity": 2}
{"drug1": "donepezil", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "edrophonium", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "donepezil", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Bretylium", "drug2": "clonidine", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of clonidine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "tizanidine", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of tizanidine.", "severity": 2}
{"drug1": "nadolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "diltiazem may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "practolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Bretylium", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "edrophonium", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "memantine", "drug2": "timolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "timolol", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "disopyramide", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "Demecarium", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "memantine", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Bretylium", "drug2": "tizanidine", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of tizanidine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Dronedarone", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of Dronedarone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Dronedarone", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Dronedarone.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "galanthamine", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "diltiazem", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of diltiazem.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "labetalol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "ambenonium", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "diltiazem", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of diltiazem.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ambenonium", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "Demecarium", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "timolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "GUANFACINE may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "clonidine", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of clonidine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "DIHYDROCODEINE", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Ketobemidone", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of Ketobemidone.", "severity": 2}
{"drug1": "Bretylium", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "edrophonium", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "donepezil", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "digitoxin", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "digitoxin may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "ambenonium", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "donepezil", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "Pasireotide may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "practolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "galanthamine", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Dronedarone", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of Dronedarone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "hydromorphone", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of hydromorphone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "physostigmine", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "malathion", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "Demecarium", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "methadone", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of methadone.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "practolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "mefloquine", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "diltiazem", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of diltiazem.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "memantine", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "atenolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "malathion", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "malathion", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "malathion", "drug2": "practolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "sotalol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "sotalol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "methyldopa", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "alprenolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "timolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "labetalol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "diltiazem may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "timolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "memantine", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "decamethonium", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "decamethonium", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "butorphanol", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of butorphanol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "digoxin", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "malathion", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "digoxin", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "Demecarium", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "diltiazem may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "labetalol", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "clonidine", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of clonidine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "propoxyphene", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of propoxyphene.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "deslanoside", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "deslanoside may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "timolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "morphine", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of morphine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "timolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "decamethonium", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "Demecarium", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "Daclatasvir may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "acetyldigitoxin may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "ouabain", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "ouabain may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "diltiazem may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "HYDROCODONE", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of HYDROCODONE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "practolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "memantine", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "tizanidine", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of tizanidine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "methyldopa", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "timolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "malathion", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "memantine", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "sotalol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "malathion", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "DEXMEDETOMIDINE", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Octreotide", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "malathion", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "malathion", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "memantine", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "timolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "donepezil", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "edrophonium", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "diltiazem", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of diltiazem.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "sotalol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "donepezil", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "ALFENTANIL", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of ALFENTANIL.", "severity": 2}
{"drug1": "malathion", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "pentazocine", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of pentazocine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "timolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "malathion", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "edrophonium", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "Octreotide", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "memantine", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "practolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "Demecarium", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "Octreotide", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "donepezil", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Fingolimod may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "Demecarium", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "Lanreotide may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Bretylium", "drug2": "diltiazem", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of diltiazem.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "practolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "practolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "decamethonium", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "practolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Demecarium", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "practolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "donepezil", "drug2": "timolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "propranolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Bretylium", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "sotalol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "alprenolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "malathion", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Methadyl acetate", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of Methadyl acetate.", "severity": 2}
{"drug1": "donepezil", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "DEXMEDETOMIDINE", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "Lanreotide may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "HEROIN", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of HEROIN.", "severity": 2}
{"drug1": "alprenolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "labetalol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "digoxin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "practolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "digoxin", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "digoxin", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "digoxin", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "sotalol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "atenolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "Bretylium", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Ethylmorphine", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of Ethylmorphine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "malathion", "drug2": "timolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "nalbuphine", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of nalbuphine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "buprenorphine", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of buprenorphine.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "malathion", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "VERAPAMIL", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of VERAPAMIL.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "timolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "VERAPAMIL", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of VERAPAMIL.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "oxycodone", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of oxycodone.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "disopyramide", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "nadolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Octreotide", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Bretylium", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "propranolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "practolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "REMIFENTANIL may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "timolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "REMIFENTANIL may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "digoxin", "drug2": "tizanidine", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of tizanidine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "memantine", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "VERAPAMIL may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "decamethonium", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "malathion", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Normethadone", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of Normethadone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Dronedarone", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Dronedarone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "GUANFACINE may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "clonidine", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of clonidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Demecarium", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "practolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "penbutolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "timolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "codeine", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of codeine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "edrophonium", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "diltiazem", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "diltiazem may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Lanreotide may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "tizanidine", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of tizanidine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "malathion", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "clonidine", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "VERAPAMIL", "interaction_type": 54, "interaction_text": "Telithromycin may increase the bradycardic activities of VERAPAMIL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "donepezil", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Lanreotide may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Bretylium", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "sotalol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "donepezil", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "physostigmine", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "memantine", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "VERAPAMIL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Demecarium", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "memantine", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "practolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "labetalol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "memantine", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "Demecarium", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "physostigmine", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "timolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "decamethonium", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "GUANFACINE may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "atenolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "memantine", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "practolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Pasireotide may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "mefloquine", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "malathion", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "VERAPAMIL", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of VERAPAMIL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "donepezil", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "ambenonium", "drug2": "practolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "celiprolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "disopyramide", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "malathion", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "DIPHENOXYLATE", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "donepezil", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "mefloquine", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "amiodarone", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "donepezil", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "nadolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "practolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Bretylium", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "oxymorphone", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of oxymorphone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "donepezil", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "propranolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "malathion", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "GUANFACINE may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "timolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "memantine", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "REMIFENTANIL may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "ambenonium", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "decamethonium", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "nadolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "Octreotide", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "malathion", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "nadolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "nadolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "timolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "ambenonium", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "practolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "digoxin", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Demecarium", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "disopyramide", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "BOPINDOLOL may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "atenolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "practolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "meperidine", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of meperidine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "timolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "propranolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Dronedarone", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Dronedarone.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "levorphanol", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of levorphanol.", "severity": 2}
{"drug1": "memantine", "drug2": "practolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "Octreotide", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "timolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "nadolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "galanthamine", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of galanthamine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "atenolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "donepezil", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "memantine", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "practolol", "interaction_type": 54, "interaction_text": "REMIFENTANIL may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "REMIFENTANIL may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "practolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "propranolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "VERAPAMIL", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of VERAPAMIL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "VERAPAMIL may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "donepezil", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "decamethonium", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "timolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "Bevantolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "atenolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "ambenonium", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "VERAPAMIL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Dronedarone", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of Dronedarone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Octreotide", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "decamethonium", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "atenolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "atenolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "donepezil", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "labetalol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "labetalol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "digoxin", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "timolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Pasireotide may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "timolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "memantine", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "timolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Octreotide", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Octreotide.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "nadolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "galanthamine", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "edrophonium", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "timolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "timolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "Octreotide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "sotalol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "practolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Octreotide", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "donepezil", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of donepezil.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "physostigmine", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "REMIFENTANIL", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "malathion", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Octreotide", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Octreotide.", "severity": 2}
{"drug1": "Bretylium", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "timolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Octreotide", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "edrophonium", "drug2": "timolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "diltiazem may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "DEXMEDETOMIDINE", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "Metipranolol may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "SOFOSBUVIR", "drug2": "amiodarone", "interaction_type": 54, "interaction_text": "SOFOSBUVIR may increase the bradycardic activities of amiodarone.", "severity": 2}
{"drug1": "physostigmine", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "disopyramide", "drug2": "practolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "sotalol", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "physostigmine", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "Nebivolol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "digoxin", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "nadolol", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "nadolol may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "donepezil", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "BISOPROLOL may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "REMIFENTANIL may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "practolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "BENDROFLUMETHIAZIDE may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "decamethonium", "drug2": "practolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "memantine", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "timolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "timolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "alprenolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "malathion", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "betaxolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "timolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "clonidine", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "clonidine may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "pyridostigmine may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "methyldopa", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of methyldopa.", "severity": 2}
{"drug1": "ambenonium", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "diltiazem may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "tizanidine may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "memantine", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "VERAPAMIL", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of VERAPAMIL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "LEVOBUNOLOL may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "memantine", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "ambenonium", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "malathion", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "practolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "practolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "ambenonium", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "metoprolol may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "DEXMEDETOMIDINE may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "propranolol", "drug2": "SUFENTANIL", "interaction_type": 54, "interaction_text": "propranolol may increase the bradycardic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "DEXMEDETOMIDINE", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "memantine", "drug2": "celiprolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of celiprolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "betaxolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of betaxolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "timolol", "interaction_type": 54, "interaction_text": "metoclopramide may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "ambenonium", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "malathion", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "malathion may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "Ruxolitinib may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "practolol", "interaction_type": 54, "interaction_text": "physostigmine may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Tramadol", "interaction_type": 54, "interaction_text": "succinylcholine may increase the bradycardic activities of Tramadol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "ambenonium may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "donepezil", "drug2": "nadolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of nadolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "donepezil", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "BUPRANOLOL may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "acetyldigitoxin", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of acetyldigitoxin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Metipranolol", "interaction_type": 54, "interaction_text": "ALFENTANIL may increase the bradycardic activities of Metipranolol.", "severity": 2}
{"drug1": "donepezil", "drug2": "Pasireotide", "interaction_type": 54, "interaction_text": "donepezil may increase the bradycardic activities of Pasireotide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "celiprolol may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "GUANFACINE", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "VERAPAMIL may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "methyldopa may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "alprenolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of alprenolol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "timolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of timolol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "practolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "oxprenolol may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "Regorafenib may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "midodrine", "interaction_type": 54, "interaction_text": "carvedilol may increase the bradycardic activities of midodrine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "Isoflurophate may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "digoxin", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "mefloquine", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "Arotinolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "BUPRANOLOL", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Bretylium", "drug2": "rivastigmine", "interaction_type": 54, "interaction_text": "Bretylium may increase the bradycardic activities of rivastigmine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "deslanoside", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of deslanoside.", "severity": 2}
{"drug1": "memantine", "drug2": "atenolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of atenolol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "sotalol", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "galanthamine", "drug2": "LEVOBUNOLOL", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "edrophonium", "drug2": "carvedilol", "interaction_type": 54, "interaction_text": "edrophonium may increase the bradycardic activities of carvedilol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "Octreotide", "drug2": "tizanidine", "interaction_type": 54, "interaction_text": "Octreotide may increase the bradycardic activities of tizanidine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Crizotinib", "interaction_type": 54, "interaction_text": "sotalol may increase the bradycardic activities of Crizotinib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "BISOPROLOL", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of BISOPROLOL.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "NEOSTIGMINE may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "mefloquine may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "rivastigmine may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Lanreotide", "interaction_type": 54, "interaction_text": "GUANFACINE may increase the bradycardic activities of Lanreotide.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "oxprenolol", "interaction_type": 54, "interaction_text": "tubocurarine may increase the bradycardic activities of oxprenolol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Arotinolol", "interaction_type": 54, "interaction_text": "amiodarone may increase the bradycardic activities of Arotinolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ESMOLOL", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of ESMOLOL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "acebutolol may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "decamethonium", "drug2": "penbutolol", "interaction_type": 54, "interaction_text": "decamethonium may increase the bradycardic activities of penbutolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "labetalol", "interaction_type": 54, "interaction_text": "galanthamine may increase the bradycardic activities of labetalol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "propranolol", "interaction_type": 54, "interaction_text": "Dronedarone may increase the bradycardic activities of propranolol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Tofacitinib may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "Demecarium", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "Demecarium may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "BOPINDOLOL", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of BOPINDOLOL.", "severity": 2}
{"drug1": "digoxin", "drug2": "Fingolimod", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of Fingolimod.", "severity": 2}
{"drug1": "memantine", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "memantine may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "practolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of practolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "CARTEOLOL", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of CARTEOLOL.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Bevantolol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of Bevantolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Nebivolol", "interaction_type": 54, "interaction_text": "disopyramide may increase the bradycardic activities of Nebivolol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "metoprolol", "interaction_type": 54, "interaction_text": "dipyridamole may increase the bradycardic activities of metoprolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "ouabain", "interaction_type": 54, "interaction_text": "CARTEOLOL may increase the bradycardic activities of ouabain.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Ivabradine", "interaction_type": 54, "interaction_text": "VERAPAMIL may increase the bradycardic activities of Ivabradine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "propafenone", "interaction_type": 54, "interaction_text": "SUFENTANIL may increase the bradycardic activities of propafenone.", "severity": 2}
{"drug1": "digoxin", "drug2": "acebutolol", "interaction_type": 54, "interaction_text": "digoxin may increase the bradycardic activities of acebutolol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "digitoxin", "interaction_type": 54, "interaction_text": "ESMOLOL may increase the bradycardic activities of digitoxin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "ceritinib", "interaction_type": 54, "interaction_text": "penbutolol may increase the bradycardic activities of ceritinib.", "severity": 2}
{"drug1": "brimonidine", "drug2": "digoxin", "interaction_type": 54, "interaction_text": "brimonidine may increase the bradycardic activities of digoxin.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "sotalol", "interaction_type": 54, "interaction_text": "Echothiophate may increase the bradycardic activities of sotalol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "indapamide", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "indapamide may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "polythiazide", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "polythiazide", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "polythiazide", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "metolazone", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "indapamide", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "indapamide may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "polythiazide", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "metolazone", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "polythiazide", "drug2": "duloxetine", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of duloxetine.", "severity": 2}
{"drug1": "metolazone", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "duloxetine", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of duloxetine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "polythiazide", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "metolazone", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "metolazone", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "polythiazide", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "duloxetine", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of duloxetine.", "severity": 2}
{"drug1": "metolazone", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "fluvoxamine", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of fluvoxamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "chlorthalidone may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "indapamide", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "indapamide may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "hydroflumethiazide may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "polythiazide", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "polythiazide may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "hydrochlorothiazide may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "trichlormethiazide may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "indapamide", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "indapamide may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "citalopram", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of citalopram.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Escitalopram", "interaction_type": 55, "interaction_text": "QUINETHAZONE may increase the hyponatremic activities of Escitalopram.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "paroxetine", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of paroxetine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "sertraline", "interaction_type": 55, "interaction_text": "methyclothiazide may increase the hyponatremic activities of sertraline.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "venlafaxine", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of venlafaxine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "fluoxetine", "interaction_type": 55, "interaction_text": "chlorothiazide may increase the hyponatremic activities of fluoxetine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Milnacipran", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of Milnacipran.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Levomilnacipran", "interaction_type": 55, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hyponatremic activities of Levomilnacipran.", "severity": 2}
{"drug1": "metolazone", "drug2": "nefazodone", "interaction_type": 55, "interaction_text": "metolazone may increase the hyponatremic activities of nefazodone.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "theobromine", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with theobromine.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "D-mannitol", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with D-mannitol.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "AMILORIDE", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with AMILORIDE.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "PAMABROM", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with PAMABROM.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "methyclothiazide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with methyclothiazide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "spironolactone", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with spironolactone.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "methazolamide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with methazolamide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Eplerenone", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Eplerenone.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Mersalyl", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Mersalyl.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "cyclothiazide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with cyclothiazide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Torasemide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Torasemide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "bumetanide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with bumetanide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "chlorthalidone", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with chlorthalidone.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "indapamide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with indapamide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "ETHACRYNIC ACID", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with ETHACRYNIC ACID.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Canrenoic acid", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Canrenoic acid.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "QUINETHAZONE", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with QUINETHAZONE.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "polythiazide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with polythiazide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "potassium ion", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with potassium ion.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "trichlormethiazide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with trichlormethiazide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "triamterene", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with triamterene.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "chlorothiazide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with chlorothiazide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "hydrochlorothiazide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with hydrochlorothiazide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Drospirenone", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Drospirenone.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with BENDROFLUMETHIAZIDE.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "hydroflumethiazide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with hydroflumethiazide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "metolazone", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with metolazone.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Tolvaptan", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Tolvaptan.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Conivaptan", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Conivaptan.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Potassium citrate", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Potassium citrate.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "furosemide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with furosemide.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "Efonidipine", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Efonidipine.", "severity": 3}
{"drug1": "Candesartan cilexetil", "drug2": "acetazolamide", "interaction_type": 56, "interaction_text": "The risk or severity of hypotension can be increased when Candesartan cilexetil is combined with acetazolamide.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "fenoprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of fenoprofen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "fenoprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of fenoprofen.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "Valrubicin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of Valrubicin.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Pimecrolimus", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Pimecrolimus.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "epirizole", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of epirizole.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "meclofenamic acid", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of meclofenamic acid.", "severity": 3}
{"drug1": "Naftifine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Naftifine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "mesalamine", "drug2": "celecoxib", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of celecoxib.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "metolazone", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of metolazone.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Salsalate", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Salsalate.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "sulfamethoxazole", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of sulfamethoxazole.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "BALSALAZIDE", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of BALSALAZIDE.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Apremilast", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Apremilast.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "epirizole", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of epirizole.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Magnesium salicylate", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Magnesium salicylate.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "ETOFENAMATE", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of ETOFENAMATE.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "fenoprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of fenoprofen.", "severity": 3}
{"drug1": "metrizamide", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "metrizamide may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "fenbufen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of fenbufen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "sulfasalazine", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of sulfasalazine.", "severity": 3}
{"drug1": "tobramycin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "tobramycin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "bezafibrate", "drug2": "cyclosporin A", "interaction_type": 57, "interaction_text": "bezafibrate may increase the nephrotoxic activities of cyclosporin A.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "mesalamine", "drug2": "epirizole", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of epirizole.", "severity": 3}
{"drug1": "mycophenolic acid", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "mycophenolic acid may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "spironolactone", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of spironolactone.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "meclofenamic acid", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of meclofenamic acid.", "severity": 3}
{"drug1": "mesalamine", "drug2": "niflumic acid", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of niflumic acid.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "ketoprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of ketoprofen.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "salicylic acid", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of salicylic acid.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Canrenoic acid", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Canrenoic acid.", "severity": 3}
{"drug1": "mesalamine", "drug2": "oxaprozin", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of oxaprozin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Nepafenac", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Nepafenac.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "triamterene", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of triamterene.", "severity": 3}
{"drug1": "celecoxib", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "celecoxib may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Propacetamol", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Propacetamol.", "severity": 3}
{"drug1": "Valrubicin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "Valrubicin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Drospirenone", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Drospirenone.", "severity": 3}
{"drug1": "ribostamycin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "ribostamycin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "fenoprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of fenoprofen.", "severity": 3}
{"drug1": "resveratrol", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "resveratrol may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "SERATRODAST", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of SERATRODAST.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "BENZYDAMINE", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of BENZYDAMINE.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Nepafenac", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Nepafenac.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Enalaprilat", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Enalaprilat.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "tolmetin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of tolmetin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "zaltoprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of zaltoprofen.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Aceclofenac", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Aceclofenac.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Icatibant", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Icatibant.", "severity": 3}
{"drug1": "mesalamine", "drug2": "fenoprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of fenoprofen.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "antipyrine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of antipyrine.", "severity": 3}
{"drug1": "plicamycin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "plicamycin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "tolfenamic acid", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of tolfenamic acid.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Droxicam", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Droxicam.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Loxoprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Loxoprofen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Aceclofenac", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Aceclofenac.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "doxorubicin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of doxorubicin.", "severity": 3}
{"drug1": "sulindac", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "sulindac may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "IDARUBICIN", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "IDARUBICIN may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "IDARUBICIN", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "IDARUBICIN may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "CLONIXIN", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of CLONIXIN.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "quinapril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of quinapril.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "chlorothiazide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of chlorothiazide.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "bumetanide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of bumetanide.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "meclofenamic acid", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of meclofenamic acid.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "nimesulide", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of nimesulide.", "severity": 3}
{"drug1": "mesalamine", "drug2": "leflunomide", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of leflunomide.", "severity": 3}
{"drug1": "Apremilast", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Apremilast may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Masoprocol", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Masoprocol may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "ibuprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of ibuprofen.", "severity": 3}
{"drug1": "Valrubicin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "Valrubicin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "Valrubicin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "Valrubicin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "antipyrine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "antipyrine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Icatibant", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Icatibant may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "plicamycin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "plicamycin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Etoricoxib", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Etoricoxib.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Pimecrolimus", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Pimecrolimus.", "severity": 3}
{"drug1": "plicamycin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "plicamycin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "doxorubicin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of doxorubicin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "ibuprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of ibuprofen.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "plicamycin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of plicamycin.", "severity": 3}
{"drug1": "netilmicin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "netilmicin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Propacetamol", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Propacetamol.", "severity": 3}
{"drug1": "doxorubicin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "doxorubicin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "daunorubicin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of daunorubicin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Pimecrolimus", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Pimecrolimus.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Apremilast", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Apremilast.", "severity": 3}
{"drug1": "doxorubicin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "doxorubicin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "doxorubicin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "doxorubicin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "acetazolamide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of acetazolamide.", "severity": 3}
{"drug1": "mesalamine", "drug2": "zaltoprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of zaltoprofen.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Aceclofenac", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Aceclofenac.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "indomethacin", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of indomethacin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "mesalamine", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of mesalamine.", "severity": 3}
{"drug1": "mesalamine", "drug2": "SERATRODAST", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of SERATRODAST.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "floctafenine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of floctafenine.", "severity": 3}
{"drug1": "cisplatin", "drug2": "Torasemide", "interaction_type": 57, "interaction_text": "cisplatin may increase the nephrotoxic activities of Torasemide.", "severity": 3}
{"drug1": "Etofibrate", "drug2": "cyclosporin A", "interaction_type": 57, "interaction_text": "Etofibrate may increase the nephrotoxic activities of cyclosporin A.", "severity": 3}
{"drug1": "streptozocin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "streptozocin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "mycophenolate mofetil", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of mycophenolate mofetil.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "azelastine", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of azelastine.", "severity": 3}
{"drug1": "Valrubicin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "Valrubicin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "daunorubicin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "daunorubicin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "ketorolac", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "ketorolac may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "antipyrine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of antipyrine.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "trandolapril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of trandolapril.", "severity": 3}
{"drug1": "paromomycin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "paromomycin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "niflumic acid", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of niflumic acid.", "severity": 3}
{"drug1": "paromomycin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "paromomycin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "mesalamine", "drug2": "mycophenolate mofetil", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of mycophenolate mofetil.", "severity": 3}
{"drug1": "amikacin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "amikacin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "SERATRODAST", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of SERATRODAST.", "severity": 3}
{"drug1": "ADAPALENE", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "ADAPALENE may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "zaltoprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of zaltoprofen.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "sulfasalazine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of sulfasalazine.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "tiaprofenic acid", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of tiaprofenic acid.", "severity": 3}
{"drug1": "Amrubicin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "Amrubicin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "suprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of suprofen.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "zaltoprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "zaltoprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "azelastine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of azelastine.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "ZILEUTON", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of ZILEUTON.", "severity": 3}
{"drug1": "cisplatin", "drug2": "bumetanide", "interaction_type": 57, "interaction_text": "cisplatin may increase the nephrotoxic activities of bumetanide.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "etodolac", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of etodolac.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "losartan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of losartan.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Choline magnesium trisalicylate", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Choline magnesium trisalicylate.", "severity": 3}
{"drug1": "gemfibrozil", "drug2": "cyclosporin A", "interaction_type": 57, "interaction_text": "gemfibrozil may increase the nephrotoxic activities of cyclosporin A.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "hydroflumethiazide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of hydroflumethiazide.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Droxicam", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Droxicam.", "severity": 3}
{"drug1": "Valrubicin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "Valrubicin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Salsalate", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Salsalate.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Pimecrolimus", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Pimecrolimus.", "severity": 3}
{"drug1": "gentamicin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "gentamicin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "metrizamide", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "metrizamide may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Potassium citrate", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Potassium citrate.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "daunorubicin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of daunorubicin.", "severity": 3}
{"drug1": "gentamicin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "gentamicin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "Iron sucrose", "drug2": "DIMERCAPROL", "interaction_type": 57, "interaction_text": "Iron sucrose may increase the nephrotoxic activities of DIMERCAPROL.", "severity": 3}
{"drug1": "mesalamine", "drug2": "diflunisal", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of diflunisal.", "severity": 3}
{"drug1": "Amrubicin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "Amrubicin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "amikacin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of amikacin.", "severity": 3}
{"drug1": "mesalamine", "drug2": "mefenamic acid", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of mefenamic acid.", "severity": 3}
{"drug1": "Amrubicin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "Amrubicin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "ibuprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "ibuprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Lumiracoxib", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Lumiracoxib.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Lumiracoxib", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Lumiracoxib.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Salsalate", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Salsalate.", "severity": 3}
{"drug1": "kanamycin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "kanamycin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Magnesium salicylate", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Magnesium salicylate.", "severity": 3}
{"drug1": "amikacin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "amikacin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "mesalamine", "drug2": "NAPROXEN", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of NAPROXEN.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "ribostamycin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of ribostamycin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "cyclothiazide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of cyclothiazide.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "tenoxicam", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of tenoxicam.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "flurbiprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of flurbiprofen.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "ketorolac", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of ketorolac.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "metrizamide", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of metrizamide.", "severity": 3}
{"drug1": "ETOFENAMATE", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "ETOFENAMATE may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "mesalamine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of mesalamine.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "tolfenamic acid", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of tolfenamic acid.", "severity": 3}
{"drug1": "mesalamine", "drug2": "mycophenolic acid", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of mycophenolic acid.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Lornoxicam", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Lornoxicam.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "oxaprozin", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of oxaprozin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "tenoxicam", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of tenoxicam.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Choline magnesium trisalicylate.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "BENZYDAMINE", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of BENZYDAMINE.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Icatibant", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Icatibant.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "nabumetone", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of nabumetone.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "resveratrol", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of resveratrol.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "Arbekacin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of Arbekacin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "indomethacin", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of indomethacin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Apremilast", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Apremilast.", "severity": 3}
{"drug1": "Arbekacin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "Arbekacin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "Salsalate", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Salsalate may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Tolvaptan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Tolvaptan.", "severity": 3}
{"drug1": "Arbekacin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "Arbekacin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "aspirin", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of aspirin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Lumiracoxib", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Lumiracoxib.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "NAPROXEN", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of NAPROXEN.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "sulfasalazine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of sulfasalazine.", "severity": 3}
{"drug1": "Amrubicin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "Amrubicin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "ketoprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of ketoprofen.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "oxyphenbutazone", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of oxyphenbutazone.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "furosemide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of furosemide.", "severity": 3}
{"drug1": "streptozocin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "streptozocin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "MOEXIPRIL", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of MOEXIPRIL.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "mefenamic acid", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of mefenamic acid.", "severity": 3}
{"drug1": "amphotericin b", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "amphotericin b may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "diclofenac", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of diclofenac.", "severity": 3}
{"drug1": "mesalamine", "drug2": "flurbiprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of flurbiprofen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "oxyphenbutazone", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of oxyphenbutazone.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "fenbufen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of fenbufen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "ETOFENAMATE", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of ETOFENAMATE.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "ketoprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of ketoprofen.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Choline magnesium trisalicylate", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Choline magnesium trisalicylate.", "severity": 3}
{"drug1": "mesalamine", "drug2": "indomethacin", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of indomethacin.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Etoricoxib", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Etoricoxib.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "niflumic acid", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of niflumic acid.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "fenbufen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of fenbufen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "oxaprozin", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of oxaprozin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "mesalamine", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of mesalamine.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "irbesartan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of irbesartan.", "severity": 3}
{"drug1": "mesalamine", "drug2": "salicylamide", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of salicylamide.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "trichlormethiazide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of trichlormethiazide.", "severity": 3}
{"drug1": "netilmicin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "netilmicin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "mefenamic acid", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of mefenamic acid.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Arbekacin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Arbekacin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "ADAPALENE", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of ADAPALENE.", "severity": 3}
{"drug1": "mesalamine", "drug2": "ETOFENAMATE", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of ETOFENAMATE.", "severity": 3}
{"drug1": "mesalamine", "drug2": "fenbufen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of fenbufen.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "theobromine", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of theobromine.", "severity": 3}
{"drug1": "epirizole", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "epirizole may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Apremilast", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Apremilast.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of BENDROFLUMETHIAZIDE.", "severity": 3}
{"drug1": "Olopatadine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Olopatadine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "nabumetone", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "nabumetone may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "DIMERCAPROL", "interaction_type": 57, "interaction_text": "FERRIC PYROPHOSPHATE may increase the nephrotoxic activities of DIMERCAPROL.", "severity": 3}
{"drug1": "mesalamine", "drug2": "carprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of carprofen.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "resveratrol", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of resveratrol.", "severity": 3}
{"drug1": "azelastine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "azelastine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "aspirin", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "aspirin may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "doxorubicin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "doxorubicin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "oxyphenbutazone", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of oxyphenbutazone.", "severity": 3}
{"drug1": "indomethacin", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "indomethacin may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "etodolac", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of etodolac.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "valsartan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of valsartan.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "ramipril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of ramipril.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "carprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of carprofen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "alclofenac", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of alclofenac.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Naftifine", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Naftifine.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "ZILEUTON", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of ZILEUTON.", "severity": 3}
{"drug1": "tobramycin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "tobramycin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "lisinopril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of lisinopril.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "tiaprofenic acid", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of tiaprofenic acid.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "diclofenac", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of diclofenac.", "severity": 3}
{"drug1": "IDARUBICIN", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "IDARUBICIN may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "metrizamide", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "metrizamide may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "mycophenolate mofetil", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "mycophenolate mofetil may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "SERATRODAST", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of SERATRODAST.", "severity": 3}
{"drug1": "bacitracin", "drug2": "streptomycin", "interaction_type": 57, "interaction_text": "bacitracin may increase the nephrotoxic activities of streptomycin.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Naftifine", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Naftifine.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "Amrubicin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of Amrubicin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "streptozocin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of streptozocin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "zaltoprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of zaltoprofen.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Aceclofenac", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Aceclofenac.", "severity": 3}
{"drug1": "Epirubicin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "Epirubicin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "Epirubicin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "Epirubicin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "Epirubicin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of Epirubicin.", "severity": 3}
{"drug1": "daunorubicin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "daunorubicin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "etodolac", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of etodolac.", "severity": 3}
{"drug1": "Pimecrolimus", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Pimecrolimus may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "acemetacin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of acemetacin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "ZILEUTON", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of ZILEUTON.", "severity": 3}
{"drug1": "acemetacin", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "acemetacin may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "gentamicin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "gentamicin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "ketoprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of ketoprofen.", "severity": 3}
{"drug1": "niflumic acid", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "niflumic acid may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "PERINDOPRIL", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of PERINDOPRIL.", "severity": 3}
{"drug1": "Spectinomycin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "Spectinomycin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Candesartan cilexetil", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Candesartan cilexetil.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "sulindac", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of sulindac.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Olsalazine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Olsalazine.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "antipyrine", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of antipyrine.", "severity": 3}
{"drug1": "tobramycin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "tobramycin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "chloroquine", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of chloroquine.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "melphalan", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of melphalan.", "severity": 3}
{"drug1": "streptomycin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "streptomycin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "AMILORIDE", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of AMILORIDE.", "severity": 3}
{"drug1": "streptomycin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "streptomycin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "daunorubicin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "daunorubicin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "daunorubicin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "daunorubicin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "BENZYDAMINE", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "BENZYDAMINE may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "celecoxib", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of celecoxib.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Torasemide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Torasemide.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "diflunisal", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of diflunisal.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "rescinnamine", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of rescinnamine.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Nepafenac", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Nepafenac.", "severity": 3}
{"drug1": "metrizamide", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "metrizamide may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "TASOSARTAN", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of TASOSARTAN.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Loxoprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Loxoprofen.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "etodolac", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of etodolac.", "severity": 3}
{"drug1": "FERRIC CITRATE", "drug2": "DIMERCAPROL", "interaction_type": 57, "interaction_text": "FERRIC CITRATE may increase the nephrotoxic activities of DIMERCAPROL.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Droxicam", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Droxicam.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "cilazapril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of cilazapril.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "indomethacin", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of indomethacin.", "severity": 3}
{"drug1": "mesalamine", "drug2": "CLONIXIN", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of CLONIXIN.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "potassium ion", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of potassium ion.", "severity": 3}
{"drug1": "streptozocin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "streptozocin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "plicamycin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "plicamycin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "VANCOMYCIN", "drug2": "piperacillin", "interaction_type": 57, "interaction_text": "VANCOMYCIN may increase the nephrotoxic activities of piperacillin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Propacetamol", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Propacetamol.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Lornoxicam", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Lornoxicam.", "severity": 3}
{"drug1": "sulfasalazine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "sulfasalazine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Lumiracoxib", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Lumiracoxib.", "severity": 3}
{"drug1": "netilmicin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "netilmicin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "mesalamine", "drug2": "ZILEUTON", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of ZILEUTON.", "severity": 3}
{"drug1": "mesalamine", "drug2": "ADAPALENE", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of ADAPALENE.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "nabumetone", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of nabumetone.", "severity": 3}
{"drug1": "mesalamine", "drug2": "etodolac", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of etodolac.", "severity": 3}
{"drug1": "PIRFENIDONE", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "PIRFENIDONE may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "nimesulide", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of nimesulide.", "severity": 3}
{"drug1": "ketoprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "ketoprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "tolfenamic acid", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of tolfenamic acid.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Droxicam", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Droxicam.", "severity": 3}
{"drug1": "flurbiprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "flurbiprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "metrizamide", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "metrizamide may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "oxyphenbutazone", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of oxyphenbutazone.", "severity": 3}
{"drug1": "Spectinomycin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "Spectinomycin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Lornoxicam", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Lornoxicam.", "severity": 3}
{"drug1": "amikacin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "amikacin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "nimesulide", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of nimesulide.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "ADAPALENE", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of ADAPALENE.", "severity": 3}
{"drug1": "Spectinomycin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "Spectinomycin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "NAPROXEN", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of NAPROXEN.", "severity": 3}
{"drug1": "Arbekacin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "Arbekacin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "mefenamic acid", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of mefenamic acid.", "severity": 3}
{"drug1": "fenofibrate", "drug2": "tacrolimus", "interaction_type": 57, "interaction_text": "fenofibrate may increase the nephrotoxic activities of tacrolimus.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Nepafenac", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Nepafenac.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Masoprocol", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Masoprocol.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Masoprocol", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Masoprocol.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Spirapril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Spirapril.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "indomethacin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of indomethacin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Icatibant", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Icatibant.", "severity": 3}
{"drug1": "Epirubicin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "Epirubicin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "mycophenolic acid", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of mycophenolic acid.", "severity": 3}
{"drug1": "Teriflunomide", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Teriflunomide may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "PIRFENIDONE", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of PIRFENIDONE.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "alclofenac", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of alclofenac.", "severity": 3}
{"drug1": "alclofenac", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "alclofenac may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "mesalamine", "drug2": "suprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of suprofen.", "severity": 3}
{"drug1": "Etoricoxib", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Etoricoxib may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Amrubicin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "Amrubicin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Spectinomycin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Spectinomycin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "mefenamic acid", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of mefenamic acid.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "hydrochlorothiazide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of hydrochlorothiazide.", "severity": 3}
{"drug1": "ribostamycin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "ribostamycin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "oxaprozin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of oxaprozin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "suprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of suprofen.", "severity": 3}
{"drug1": "Propacetamol", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Propacetamol may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Aceclofenac", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Aceclofenac may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "leflunomide", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "leflunomide may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "leflunomide", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of leflunomide.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "ketorolac", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of ketorolac.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "amikacin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of amikacin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "mycophenolate mofetil", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of mycophenolate mofetil.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "ADAPALENE", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of ADAPALENE.", "severity": 3}
{"drug1": "mesalamine", "drug2": "antipyrine", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of antipyrine.", "severity": 3}
{"drug1": "Arbekacin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "Arbekacin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "fenbufen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "fenbufen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "ribostamycin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "ribostamycin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "chlorthalidone", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of chlorthalidone.", "severity": 3}
{"drug1": "ribostamycin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "ribostamycin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "oxaprozin", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "oxaprozin may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "NAPROXEN", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of NAPROXEN.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "chloroquine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of chloroquine.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "sulindac", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of sulindac.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Masoprocol", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Masoprocol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "salicylamide", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of salicylamide.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Masoprocol", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Masoprocol.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "ETHACRYNIC ACID", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of ETHACRYNIC ACID.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Etoricoxib", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Etoricoxib.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "chloroquine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of chloroquine.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "ADAPALENE", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of ADAPALENE.", "severity": 3}
{"drug1": "tobramycin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "tobramycin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "sulindac", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of sulindac.", "severity": 3}
{"drug1": "Lornoxicam", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Lornoxicam may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tobramycin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "tobramycin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "kanamycin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of kanamycin.", "severity": 3}
{"drug1": "mesalamine", "drug2": "ketoprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of ketoprofen.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "IDARUBICIN", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of IDARUBICIN.", "severity": 3}
{"drug1": "Lumiracoxib", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Lumiracoxib may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "diflunisal", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of diflunisal.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "benazepril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of benazepril.", "severity": 3}
{"drug1": "gentamicin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "gentamicin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "mesalamine", "drug2": "sulfasalazine", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of sulfasalazine.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "carprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of carprofen.", "severity": 3}
{"drug1": "mesalamine", "drug2": "tolfenamic acid", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of tolfenamic acid.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Masoprocol", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Masoprocol.", "severity": 3}
{"drug1": "mesalamine", "drug2": "oxyphenbutazone", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of oxyphenbutazone.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Apremilast", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Apremilast.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "tolmetin", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of tolmetin.", "severity": 3}
{"drug1": "streptozocin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "streptozocin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "tiaprofenic acid", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of tiaprofenic acid.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Teriflunomide", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Teriflunomide.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Choline magnesium trisalicylate", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Choline magnesium trisalicylate.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Magnesium salicylate", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Magnesium salicylate.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "celecoxib", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of celecoxib.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "doxorubicin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "doxorubicin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "BENZYDAMINE", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of BENZYDAMINE.", "severity": 3}
{"drug1": "Droxicam", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Droxicam may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Teriflunomide", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Teriflunomide.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "ZILEUTON", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of ZILEUTON.", "severity": 3}
{"drug1": "Loxoprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Loxoprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "bacitracin", "drug2": "polymyxin b", "interaction_type": 57, "interaction_text": "bacitracin may increase the nephrotoxic activities of polymyxin b.", "severity": 3}
{"drug1": "meclofenamic acid", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "meclofenamic acid may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Icatibant", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Icatibant.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "netilmicin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of netilmicin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "PIRFENIDONE", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of PIRFENIDONE.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Lumiracoxib", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Lumiracoxib.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "BALSALAZIDE", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of BALSALAZIDE.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "SERATRODAST", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of SERATRODAST.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "paromomycin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of paromomycin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Sacubitril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Sacubitril.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "fosinopril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of fosinopril.", "severity": 3}
{"drug1": "chloroquine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "chloroquine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "salicylamide", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of salicylamide.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "zaltoprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of zaltoprofen.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Aceclofenac", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Aceclofenac.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "ibuprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of ibuprofen.", "severity": 3}
{"drug1": "cisplatin", "drug2": "ETHACRYNIC ACID", "interaction_type": 57, "interaction_text": "cisplatin may increase the nephrotoxic activities of ETHACRYNIC ACID.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "resveratrol", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of resveratrol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "fenbufen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of fenbufen.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "sulfadiazine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of sulfadiazine.", "severity": 3}
{"drug1": "fenofibrate", "drug2": "cyclosporin A", "interaction_type": 57, "interaction_text": "fenofibrate may increase the nephrotoxic activities of cyclosporin A.", "severity": 3}
{"drug1": "bacitracin", "drug2": "Colistimethate", "interaction_type": 57, "interaction_text": "bacitracin may increase the nephrotoxic activities of Colistimethate.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "mycophenolic acid", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of mycophenolic acid.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Lornoxicam", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Lornoxicam.", "severity": 3}
{"drug1": "Epirubicin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "Epirubicin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "alclofenac", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of alclofenac.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "epirizole", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of epirizole.", "severity": 3}
{"drug1": "plicamycin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "plicamycin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "gentamicin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "gentamicin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "amikacin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "amikacin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "gentamicin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of gentamicin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "salicylamide", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of salicylamide.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "tenoxicam", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "tenoxicam may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Olsalazine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Olsalazine.", "severity": 3}
{"drug1": "cisplatin", "drug2": "furosemide", "interaction_type": 57, "interaction_text": "cisplatin may increase the nephrotoxic activities of furosemide.", "severity": 3}
{"drug1": "streptomycin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "streptomycin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "clofibrate", "drug2": "cyclosporin A", "interaction_type": 57, "interaction_text": "clofibrate may increase the nephrotoxic activities of cyclosporin A.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Naftifine", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Naftifine.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "tiaprofenic acid", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of tiaprofenic acid.", "severity": 3}
{"drug1": "streptomycin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "streptomycin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "mefenamic acid", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "mefenamic acid may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Icatibant", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Icatibant.", "severity": 3}
{"drug1": "streptomycin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "streptomycin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "enalapril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of enalapril.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "carprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of carprofen.", "severity": 3}
{"drug1": "mesalamine", "drug2": "ibuprofen", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of ibuprofen.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "aspirin", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of aspirin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Etoricoxib", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Etoricoxib.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "streptomycin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of streptomycin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "captopril", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of captopril.", "severity": 3}
{"drug1": "paromomycin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "paromomycin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "plicamycin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of plicamycin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "diflunisal", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of diflunisal.", "severity": 3}
{"drug1": "salicylic acid", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "salicylic acid may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "methotrexate", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "methotrexate may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Conivaptan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Conivaptan.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Eprosartan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Eprosartan.", "severity": 3}
{"drug1": "PAMIDRONIC ACID", "drug2": "thalidomide", "interaction_type": 57, "interaction_text": "PAMIDRONIC ACID may increase the nephrotoxic activities of thalidomide.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "kanamycin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of kanamycin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "nabumetone", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of nabumetone.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "IDARUBICIN", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of IDARUBICIN.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "tenoxicam", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of tenoxicam.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "tolmetin", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of tolmetin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "PAMABROM", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of PAMABROM.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "oxaprozin", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of oxaprozin.", "severity": 3}
{"drug1": "mesalamine", "drug2": "tiaprofenic acid", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of tiaprofenic acid.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "ribostamycin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of ribostamycin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "celecoxib", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of celecoxib.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Mersalyl", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Mersalyl.", "severity": 3}
{"drug1": "oxyphenbutazone", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "oxyphenbutazone may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "BENZYDAMINE", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of BENZYDAMINE.", "severity": 3}
{"drug1": "Spectinomycin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "Spectinomycin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "nabumetone", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of nabumetone.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "mesalamine", "drug2": "BENZYDAMINE", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of BENZYDAMINE.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "tenoxicam", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of tenoxicam.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "epirizole", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of epirizole.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Olopatadine", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Olopatadine.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "metrizamide", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of metrizamide.", "severity": 3}
{"drug1": "carprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "carprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "BALSALAZIDE", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of BALSALAZIDE.", "severity": 3}
{"drug1": "diflunisal", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "diflunisal may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "salicylamide", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "salicylamide may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Fenofibric acid", "drug2": "cyclosporin A", "interaction_type": 57, "interaction_text": "Fenofibric acid may increase the nephrotoxic activities of cyclosporin A.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "netilmicin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of netilmicin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Loxoprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Loxoprofen.", "severity": 3}
{"drug1": "triamterene", "drug2": "indomethacin", "interaction_type": 57, "interaction_text": "triamterene may increase the nephrotoxic activities of indomethacin.", "severity": 3}
{"drug1": "suprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "suprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "fenoprofen", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "fenoprofen may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "carprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of carprofen.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "gentamicin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of gentamicin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "flurbiprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of flurbiprofen.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "mycophenolate mofetil", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of mycophenolate mofetil.", "severity": 3}
{"drug1": "Arbekacin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "Arbekacin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "amikacin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "amikacin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Olopatadine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Olopatadine.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "celecoxib", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of celecoxib.", "severity": 3}
{"drug1": "tolmetin", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "tolmetin may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "sulfisoxazole", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of sulfisoxazole.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "CLONIXIN", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of CLONIXIN.", "severity": 3}
{"drug1": "SERATRODAST", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "SERATRODAST may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Valrubicin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Valrubicin.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "paromomycin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of paromomycin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Olopatadine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Olopatadine.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "ETOFENAMATE", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of ETOFENAMATE.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Epirubicin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Epirubicin.", "severity": 3}
{"drug1": "nimesulide", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "nimesulide may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "ribostamycin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "ribostamycin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "streptozocin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of streptozocin.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "leflunomide", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of leflunomide.", "severity": 3}
{"drug1": "IDARUBICIN", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "IDARUBICIN may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "tolfenamic acid", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "tolfenamic acid may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Salsalate", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Salsalate.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "chloroquine", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of chloroquine.", "severity": 3}
{"drug1": "floctafenine", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "floctafenine may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "sulindac", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of sulindac.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Amrubicin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Amrubicin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Olopatadine", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Olopatadine.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "flurbiprofen", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of flurbiprofen.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "nimesulide", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of nimesulide.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "salicylamide", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of salicylamide.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "niflumic acid", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of niflumic acid.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "suprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of suprofen.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of AZILSARTAN MEDOXOMIL.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Olmesartan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Olmesartan.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "azelastine", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of azelastine.", "severity": 3}
{"drug1": "mesalamine", "drug2": "salicylic acid", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of salicylic acid.", "severity": 3}
{"drug1": "mesalamine", "drug2": "meclofenamic acid", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of meclofenamic acid.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "streptomycin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of streptomycin.", "severity": 3}
{"drug1": "tiaprofenic acid", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "tiaprofenic acid may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "floctafenine", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of floctafenine.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "tolmetin", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of tolmetin.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "indapamide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of indapamide.", "severity": 3}
{"drug1": "mesalamine", "drug2": "tenoxicam", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of tenoxicam.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "tobramycin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of tobramycin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Loxoprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Loxoprofen.", "severity": 3}
{"drug1": "mesalamine", "drug2": "nabumetone", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of nabumetone.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "CLONIXIN", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of CLONIXIN.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "mycophenolate mofetil", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of mycophenolate mofetil.", "severity": 3}
{"drug1": "Spectinomycin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "Spectinomycin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Pimecrolimus", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Pimecrolimus.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "acemetacin", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of acemetacin.", "severity": 3}
{"drug1": "Nepafenac", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Nepafenac may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Olopatadine", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Olopatadine.", "severity": 3}
{"drug1": "mesalamine", "drug2": "sulindac", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of sulindac.", "severity": 3}
{"drug1": "mesalamine", "drug2": "chloroquine", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of chloroquine.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "antipyrine", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of antipyrine.", "severity": 3}
{"drug1": "etodolac", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "etodolac may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "Spectinomycin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of Spectinomycin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "aspirin", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of aspirin.", "severity": 3}
{"drug1": "CLONIXIN", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "CLONIXIN may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Choline magnesium trisalicylate may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "paromomycin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "paromomycin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "paromomycin", "drug2": "foscarnet", "interaction_type": 57, "interaction_text": "paromomycin may increase the nephrotoxic activities of foscarnet.", "severity": 3}
{"drug1": "streptozocin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "streptozocin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "mesalamine", "drug2": "PIRFENIDONE", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of PIRFENIDONE.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "NAPROXEN", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of NAPROXEN.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "diflunisal", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of diflunisal.", "severity": 3}
{"drug1": "Epirubicin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "Epirubicin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "tacrolimus", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of tacrolimus.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "aspirin", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of aspirin.", "severity": 3}
{"drug1": "kanamycin", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "kanamycin may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Propacetamol", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Propacetamol.", "severity": 3}
{"drug1": "diclofenac", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "diclofenac may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "methazolamide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of methazolamide.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Eplerenone", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Eplerenone.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Lornoxicam", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Lornoxicam.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "PIRFENIDONE", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of PIRFENIDONE.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Magnesium salicylate", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Magnesium salicylate.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "PIRFENIDONE", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of PIRFENIDONE.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "tobramycin", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of tobramycin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "CLONIXIN", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of CLONIXIN.", "severity": 3}
{"drug1": "Colistimethate", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "Colistimethate may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Loxoprofen", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Loxoprofen.", "severity": 3}
{"drug1": "IDARUBICIN", "drug2": "D-mannitol", "interaction_type": 57, "interaction_text": "IDARUBICIN may increase the nephrotoxic activities of D-mannitol.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "tolfenamic acid", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of tolfenamic acid.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Droxicam", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Droxicam.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Teriflunomide", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Teriflunomide.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Salsalate", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Salsalate.", "severity": 3}
{"drug1": "kanamycin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "kanamycin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "ibuprofen", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of ibuprofen.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Etoricoxib", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Etoricoxib.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "resveratrol", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of resveratrol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "ETOFENAMATE", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of ETOFENAMATE.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Magnesium salicylate", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Magnesium salicylate.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Propacetamol", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Propacetamol.", "severity": 3}
{"drug1": "kanamycin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "kanamycin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "alclofenac", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of alclofenac.", "severity": 3}
{"drug1": "kanamycin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "kanamycin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "daunorubicin", "drug2": "amphotericin b", "interaction_type": 57, "interaction_text": "daunorubicin may increase the nephrotoxic activities of amphotericin b.", "severity": 3}
{"drug1": "bacitracin", "drug2": "kanamycin", "interaction_type": 57, "interaction_text": "bacitracin may increase the nephrotoxic activities of kanamycin.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "flurbiprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of flurbiprofen.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "azelastine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of azelastine.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "mycophenolic acid", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of mycophenolic acid.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Efonidipine", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Efonidipine.", "severity": 3}
{"drug1": "ZILEUTON", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "ZILEUTON may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "Nepafenac", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of Nepafenac.", "severity": 3}
{"drug1": "netilmicin", "drug2": "VANCOMYCIN", "interaction_type": 57, "interaction_text": "netilmicin may increase the nephrotoxic activities of VANCOMYCIN.", "severity": 3}
{"drug1": "netilmicin", "drug2": "cisplatin", "interaction_type": 57, "interaction_text": "netilmicin may increase the nephrotoxic activities of cisplatin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "sulfasalazine", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of sulfasalazine.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "meclofenamic acid", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of meclofenamic acid.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "Teriflunomide", "interaction_type": 57, "interaction_text": "cyclosporin A may increase the nephrotoxic activities of Teriflunomide.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "methyclothiazide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of methyclothiazide.", "severity": 3}
{"drug1": "Magnesium salicylate", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "Magnesium salicylate may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "Tenofovir disoproxil", "drug2": "Lopinavir", "interaction_type": 57, "interaction_text": "Tenofovir disoproxil may increase the nephrotoxic activities of Lopinavir.", "severity": 3}
{"drug1": "BALSALAZIDE", "drug2": "salicylic acid", "interaction_type": 57, "interaction_text": "BALSALAZIDE may increase the nephrotoxic activities of salicylic acid.", "severity": 3}
{"drug1": "NAPROXEN", "drug2": "Sodium phosphate monobasic", "interaction_type": 57, "interaction_text": "NAPROXEN may increase the nephrotoxic activities of Sodium phosphate monobasic.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "suprofen", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of suprofen.", "severity": 3}
{"drug1": "mesalamine", "drug2": "Teriflunomide", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of Teriflunomide.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "Telmisartan", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of Telmisartan.", "severity": 3}
{"drug1": "mesalamine", "drug2": "alclofenac", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of alclofenac.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "mesalamine", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of mesalamine.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "QUINETHAZONE", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of QUINETHAZONE.", "severity": 3}
{"drug1": "Sodium phosphate monobasic", "drug2": "polythiazide", "interaction_type": 57, "interaction_text": "Sodium phosphate monobasic may increase the nephrotoxic activities of polythiazide.", "severity": 3}
{"drug1": "mesalamine", "drug2": "tolmetin", "interaction_type": 57, "interaction_text": "mesalamine may increase the nephrotoxic activities of tolmetin.", "severity": 3}
{"drug1": "Olsalazine", "drug2": "niflumic acid", "interaction_type": 57, "interaction_text": "Olsalazine may increase the nephrotoxic activities of niflumic acid.", "severity": 3}
{"drug1": "tacrolimus", "drug2": "Choline magnesium trisalicylate", "interaction_type": 57, "interaction_text": "tacrolimus may increase the nephrotoxic activities of Choline magnesium trisalicylate.", "severity": 3}
{"drug1": "bleomycin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "bleomycin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "5-Fluorouracil", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "5-Fluorouracil may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "PAMIDRONIC ACID", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "PAMIDRONIC ACID may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "oxaliplatin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "oxaliplatin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Gemifloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Besifloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Besifloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Epirubicin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Epirubicin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "tamoxifen", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "tamoxifen may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "tibolone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "tibolone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Regorafenib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Regorafenib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Midostaurin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Midostaurin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Lanreotide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Lanreotide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Gefitinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Gefitinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pirlindole", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Pirlindole may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Sorafenib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Sorafenib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "IDARUBICIN", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "IDARUBICIN may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "flutamide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "flutamide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "trimetrexate", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "trimetrexate may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "estramustine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "estramustine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "doxorubicin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "doxorubicin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "hydroxyurea", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "hydroxyurea may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "irinotecan", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "irinotecan may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "plicamycin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "plicamycin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "pentostatin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "pentostatin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Palbociclib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Palbociclib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "mebendazole", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "mebendazole may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "vinorelbine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "vinorelbine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "altretamine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "altretamine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "ceritinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "ceritinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Bortezomib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Bortezomib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Pazopanib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "EXEMESTANE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "EXEMESTANE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Besifloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Besifloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Ixabepilone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Ixabepilone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Pralatrexate", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Pralatrexate may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "etoposide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "etoposide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "cyclophosphamide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Bexarotene", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Bexarotene may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "tegafur", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "tegafur may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "carboplatin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "carboplatin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Midostaurin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Midostaurin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Medroxyprogesterone acetate", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Medroxyprogesterone acetate may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "carboplatin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "carboplatin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Alitretinoin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Alitretinoin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "methyltestosterone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "methyltestosterone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Abiraterone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Abiraterone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Trametinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Trametinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Dienogest", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Dienogest may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pralatrexate", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Pralatrexate may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "ciprofloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "PIRFENIDONE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "PIRFENIDONE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Medroxyprogesterone acetate", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Medroxyprogesterone acetate may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Gemifloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "methotrexate", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "methotrexate may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "HYDROXYPROGESTERONE CAPROATE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "pipobroman", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "pipobroman may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Uramustine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Uramustine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "dexamethasone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "dexamethasone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Eribulin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Eribulin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Romidepsin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Romidepsin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Lenalidomide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Lenalidomide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "tibolone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "tibolone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "sulindac", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "sulindac may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "sulindac", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "sulindac may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "IDARUBICIN", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "IDARUBICIN may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "toremifene", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "toremifene may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pomalidomide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Pomalidomide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "goserelin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "goserelin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vorinostat", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Vorinostat may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "cytarabine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "cytarabine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Clofarabine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Clofarabine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "ciprofloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Regorafenib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Regorafenib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "CABAZITAXEL", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "CABAZITAXEL may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Decitabine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Decitabine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "testolactone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "testolactone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "melphalan", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "melphalan may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "IMIQUIMOD", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "IMIQUIMOD may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "vincristine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "vincristine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Nedaplatin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Nedaplatin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "ciprofloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Clofarabine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Clofarabine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "ifosfamide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "ifosfamide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Trovafloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Trovafloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Radium-223 chloride", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Radium-223 chloride may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "lomustine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "lomustine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cytarabine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "cytarabine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Abiraterone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Abiraterone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "vinblastine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "vinblastine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "tretinoin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "tretinoin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Vinflunine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Vinflunine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "CAPECITABINE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "CAPECITABINE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "formestane", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "formestane may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Midostaurin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Midostaurin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "dexamethasone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "dexamethasone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "CAPECITABINE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "CAPECITABINE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "norfloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "norfloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Erlotinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Erlotinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Nintedanib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Nintedanib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "PAMIDRONIC ACID", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "PAMIDRONIC ACID may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "floxuridine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "floxuridine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Uramustine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Uramustine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Miltefosine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Miltefosine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Lenalidomide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Lenalidomide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "IDARUBICIN", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "IDARUBICIN may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "busulfan", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "busulfan may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Sorafenib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Sorafenib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Nilotinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "docetaxel", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "docetaxel may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "pipobroman", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "pipobroman may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nedaplatin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Nedaplatin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "CABAZITAXEL", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "CABAZITAXEL may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Cladribine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Cladribine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Miltefosine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Miltefosine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Epirubicin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Epirubicin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "TEMOPORFIN", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "TEMOPORFIN may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "vindesine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "vindesine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Enzalutamide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Enzalutamide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "EXEMESTANE", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "EXEMESTANE may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "vincristine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "vincristine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Fludarabine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Fludarabine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Sunitinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Sunitinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "amsacrine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "amsacrine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "flutamide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "flutamide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "CAPECITABINE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "CAPECITABINE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Olaparib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Olaparib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "norfloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "norfloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "plicamycin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "plicamycin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "PONATINIB", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "PONATINIB may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "TEMOPORFIN", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "TEMOPORFIN may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "azathioprine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "azathioprine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Venetoclax", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Venetoclax may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Lanreotide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Lanreotide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "topotecan", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "topotecan may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "anastrozole", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "anastrozole may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Methyl aminolevulinate", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Methyl aminolevulinate may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "vindesine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "vindesine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "RUCAPARIB", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "RUCAPARIB may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "quinacrine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "quinacrine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "anagrelide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "hydroxyurea", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "hydroxyurea may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Gallium nitrate", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Gallium nitrate may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "PONATINIB", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "PONATINIB may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "enoxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "enoxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "mitotane", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "mitotane may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ecabet", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Ecabet may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "CABAZITAXEL", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "CABAZITAXEL may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "letrozole", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "letrozole may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pefloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Pefloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "azelaic acid", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "azelaic acid may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "5-azacytidine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "5-azacytidine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "doxorubicin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "doxorubicin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "prednisone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "prednisone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "cinoxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "cinoxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Trabectedin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Trabectedin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Radium-223 chloride", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Radium-223 chloride may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "IDARUBICIN", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "IDARUBICIN may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "teniposide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "teniposide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pirlindole", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Pirlindole may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "temozolomide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "temozolomide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Belinostat", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Belinostat may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Vandetanib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "PHENYLACETIC ACID", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "PHENYLACETIC ACID may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Raltitrexed", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Raltitrexed may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "sparfloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "sparfloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "diethylstilbestrol", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "diethylstilbestrol may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "chlorambucil", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "chlorambucil may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "tretinoin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "tretinoin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "retinol", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "retinol may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "methylprednisolone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "methylprednisolone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "estramustine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "estramustine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "podophyllotoxin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "podophyllotoxin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "CABAZITAXEL", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "CABAZITAXEL may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Carfilzomib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Carfilzomib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Fludarabine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Fludarabine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Lapatinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Lapatinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Olaparib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Olaparib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Niraparib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Niraparib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vapreotide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Vapreotide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vorinostat", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Vorinostat may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "CAPECITABINE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "CAPECITABINE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "trimetrexate", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "trimetrexate may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "amsacrine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "amsacrine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "VERTEPORFIN", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "VERTEPORFIN may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Trilostane", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Trilostane may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Erismodegib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Erismodegib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vapreotide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Vapreotide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "sulindac", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "sulindac may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Calcipotriol", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Calcipotriol may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Lapatinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Lapatinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "busulfan", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "busulfan may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Vemurafenib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "altretamine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "altretamine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "CYPROTERONE ACETATE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "CYPROTERONE ACETATE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "PAMIDRONIC ACID", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "PAMIDRONIC ACID may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Carfilzomib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Carfilzomib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "methyltestosterone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "methyltestosterone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "suramin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "suramin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "mitomycin C", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "mitomycin C may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "tegafur", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "tegafur may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "etoposide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "etoposide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ixabepilone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Ixabepilone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Eribulin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Eribulin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "vindesine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "vindesine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "mycophenolic acid", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "mycophenolic acid may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pemetrexed", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Pemetrexed may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "tegafur", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "tegafur may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Valrubicin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Valrubicin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "formestane", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "formestane may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "temozolomide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "temozolomide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "mitoxantrone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "mitoxantrone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Trovafloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Trovafloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "thioguanine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "thioguanine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Nilotinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "cabergoline", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "cabergoline may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Iobenguane", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Iobenguane may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Calcipotriol", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Calcipotriol may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "6-Mercaptopurine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "6-Mercaptopurine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Uramustine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Uramustine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "pentostatin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "pentostatin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Octreotide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Octreotide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "tibolone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "tibolone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "PONATINIB", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "PONATINIB may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Amrubicin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Amrubicin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "ifosfamide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "ifosfamide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Nelarabine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Nelarabine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Lenvatinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "letrozole", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "letrozole may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "lomustine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "lomustine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "topotecan", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "topotecan may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "busulfan", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "busulfan may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "homoharringtonine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "homoharringtonine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Dexrazoxane", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Dexrazoxane may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "dacarbazine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "dacarbazine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "toremifene", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "toremifene may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "streptozocin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "streptozocin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Radium-223 chloride", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Radium-223 chloride may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "sparfloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "sparfloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "vinorelbine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "vinorelbine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "RUCAPARIB", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "RUCAPARIB may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "norfloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "norfloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "tretinoin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "tretinoin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "TRIPTORELIN", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "TRIPTORELIN may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "aminoglutethimide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "aminoglutethimide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Nelarabine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Nelarabine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "mycophenolic acid", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "mycophenolic acid may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Regorafenib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Regorafenib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "daunorubicin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "daunorubicin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "anagrelide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "azelaic acid", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "azelaic acid may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mebendazole", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "mebendazole may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Bosutinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Bosutinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Trabectedin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Trabectedin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "chlorambucil", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "chlorambucil may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Dasatinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Dasatinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "azathioprine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "azathioprine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "enoxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "enoxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "docetaxel", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "docetaxel may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Venetoclax", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Venetoclax may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Afatinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Afatinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "plicamycin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "plicamycin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cabergoline", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "cabergoline may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Pazopanib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "moxifloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "procarbazine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "procarbazine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Gatifloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Gatifloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "chlorambucil", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "chlorambucil may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "goserelin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "goserelin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "anastrozole", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "anastrozole may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Afatinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Afatinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cisplatin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "cisplatin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Fludarabine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Fludarabine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "methotrexate", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "methotrexate may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "carboplatin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "carboplatin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pemetrexed", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Pemetrexed may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Enzalutamide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Enzalutamide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "methylprednisolone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "methylprednisolone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "ifosfamide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "ifosfamide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "quinacrine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "quinacrine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "plicamycin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "plicamycin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "5-Aminolevulinic acid", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "5-Aminolevulinic acid may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "4-Methoxyphenol", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "4-Methoxyphenol may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "methylprednisolone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "methylprednisolone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Medroxyprogesterone acetate", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Medroxyprogesterone acetate may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Ibrutinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Ibrutinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "ofloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "cinoxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "cinoxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "irinotecan", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "irinotecan may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "pipobroman", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "pipobroman may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "anastrozole", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "anastrozole may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "rapamycin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "rapamycin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Degarelix", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Degarelix may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "homoharringtonine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "homoharringtonine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "oxaliplatin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "oxaliplatin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "dexamethasone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "dexamethasone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "mitomycin C", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "mitomycin C may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "diethylstilbestrol", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "diethylstilbestrol may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Masoprocol", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Masoprocol may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "dacarbazine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "dacarbazine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Pazopanib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Fulvestrant", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Fulvestrant may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "suramin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "suramin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "irinotecan", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "irinotecan may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Decitabine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Decitabine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Ecabet", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Ecabet may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "topotecan", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "topotecan may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "carmustine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "carmustine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "aminoglutethimide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "aminoglutethimide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "gemcitabine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "gemcitabine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "streptozocin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "streptozocin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "tamoxifen", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "tamoxifen may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "nilutamide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "nilutamide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "bleomycin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "bleomycin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "mechlorethamine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "mechlorethamine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "methylprednisolone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "methylprednisolone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Trametinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Trametinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Cabozantinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Cabozantinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Belinostat", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Belinostat may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "thalidomide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "thalidomide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Alitretinoin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Alitretinoin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Iobenguane", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Iobenguane may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "LEVOFLOXACIN may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "busulfan", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "busulfan may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Cladribine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Cladribine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "PIRFENIDONE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "PIRFENIDONE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Cabozantinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Cabozantinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Bortezomib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Bortezomib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Trametinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Trametinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "sulindac", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "sulindac may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "methotrexate", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "methotrexate may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "PHENYLACETIC ACID", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "PHENYLACETIC ACID may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Degarelix", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Degarelix may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Regorafenib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Regorafenib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "MEGESTROL ACETATE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "MEGESTROL ACETATE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Epirubicin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Epirubicin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "thiotepa", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "thiotepa may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "CYPROTERONE ACETATE", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "CYPROTERONE ACETATE may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "azathioprine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "azathioprine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nelarabine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Nelarabine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Bexarotene", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Bexarotene may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "formestane", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "formestane may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "4-Methoxyphenol", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "4-Methoxyphenol may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "cyclophosphamide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Bendamustine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Bendamustine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Valrubicin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Valrubicin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "chlorambucil", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "chlorambucil may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "actinomycin D", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "actinomycin D may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "CYPROTERONE ACETATE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "CYPROTERONE ACETATE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "TRIPTORELIN", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "TRIPTORELIN may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "docetaxel", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "docetaxel may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "gemcitabine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "gemcitabine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Trilostane", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Trilostane may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pemetrexed", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Pemetrexed may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Trovafloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Trovafloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "bicalutamide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "bicalutamide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Nilotinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Imatinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Imatinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "actinomycin D", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "actinomycin D may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "MEGESTROL ACETATE", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "MEGESTROL ACETATE may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "etoposide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "etoposide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "bleomycin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "bleomycin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Nintedanib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Nintedanib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "TEMOPORFIN", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "TEMOPORFIN may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "toremifene", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "toremifene may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "thioguanine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "thioguanine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Venetoclax", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Venetoclax may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "bicalutamide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "bicalutamide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "fleroxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "fleroxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Degarelix", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Degarelix may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "arsenic trioxide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Bortezomib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Bortezomib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Imatinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Imatinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "ifosfamide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "ifosfamide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Fulvestrant", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Fulvestrant may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Enzalutamide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Enzalutamide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Amrubicin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Amrubicin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Abiraterone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Abiraterone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "nilutamide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "nilutamide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Epirubicin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Epirubicin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "cabergoline", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "cabergoline may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "toremifene", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "toremifene may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Temsirolimus", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Temsirolimus may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "4-PHENYLBUTYRIC ACID", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "4-PHENYLBUTYRIC ACID may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Crizotinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "leflunomide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "leflunomide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Lenvatinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "enoxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "enoxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "mitotane", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "mitotane may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "tamoxifen", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "tamoxifen may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Amrubicin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Amrubicin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Temsirolimus", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Temsirolimus may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Octreotide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Octreotide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "streptozocin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "streptozocin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Raltitrexed", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Raltitrexed may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "4-PHENYLBUTYRIC ACID", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "4-PHENYLBUTYRIC ACID may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "trimetrexate", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "trimetrexate may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "pentostatin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "pentostatin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Gefitinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Gefitinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "mitomycin C", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "mitomycin C may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Fulvestrant", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Fulvestrant may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Niraparib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Niraparib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "azelaic acid", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "azelaic acid may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pixantrone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Pixantrone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "quinacrine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "quinacrine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "5-Fluorouracil", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "5-Fluorouracil may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pazopanib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Pazopanib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cisplatin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "cisplatin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "PONATINIB", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "PONATINIB may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Bexarotene", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Bexarotene may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Pefloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Pefloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Trifluridine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Trifluridine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Olaparib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Olaparib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "IMIQUIMOD", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "IMIQUIMOD may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Pixantrone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Pixantrone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "rapamycin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "rapamycin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Dasatinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Dasatinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "5-azacytidine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "5-azacytidine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Octreotide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Octreotide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Valrubicin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Valrubicin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "flutamide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "flutamide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Dexrazoxane", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Dexrazoxane may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Vapreotide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Vapreotide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Panobinostat may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pefloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Pefloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "thalidomide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "thalidomide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Medroxyprogesterone acetate", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Medroxyprogesterone acetate may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "oxaliplatin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "oxaliplatin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "azathioprine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "azathioprine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "daunorubicin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "daunorubicin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pralatrexate", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Pralatrexate may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "moxifloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "colchicine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "colchicine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "thiotepa", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "thiotepa may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "LEVOFLOXACIN may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "bleomycin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "bleomycin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "albendazole", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "albendazole may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Carfilzomib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Carfilzomib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "flutamide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "flutamide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "colchicine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "colchicine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "mitomycin C", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "mitomycin C may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "CABAZITAXEL", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "CABAZITAXEL may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "vinorelbine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "vinorelbine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Erlotinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Erlotinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "cytarabine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "cytarabine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Octreotide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Octreotide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Sunitinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Sunitinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pomalidomide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Pomalidomide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "azelaic acid", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "azelaic acid may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Iobenguane", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Iobenguane may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Calcipotriol", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Calcipotriol may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Trabectedin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Trabectedin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "leflunomide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "leflunomide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Masoprocol", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Masoprocol may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Vemurafenib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Cabozantinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Cabozantinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Dienogest", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Dienogest may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Bosutinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Bosutinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "gemcitabine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "gemcitabine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Palbociclib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Palbociclib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Radium-223 chloride", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Radium-223 chloride may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "colchicine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "colchicine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Gemifloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Iobenguane", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Iobenguane may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Dienogest", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Dienogest may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "MEDROGESTONE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "MEDROGESTONE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "letrozole", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "letrozole may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "leflunomide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "leflunomide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Cladribine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Cladribine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "melphalan", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "melphalan may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "VERTEPORFIN", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "VERTEPORFIN may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Miltefosine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Miltefosine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Bendamustine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Bendamustine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "MEDROGESTONE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "MEDROGESTONE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "mitoxantrone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "mitoxantrone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Lanreotide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Lanreotide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "goserelin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "goserelin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "TRIPTORELIN", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "TRIPTORELIN may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "leflunomide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "leflunomide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "albendazole", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "albendazole may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "anastrozole", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "anastrozole may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "sparfloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "sparfloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "oxaliplatin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "oxaliplatin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "IDARUBICIN", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "IDARUBICIN may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "MEGESTROL ACETATE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "MEGESTROL ACETATE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Lenalidomide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Lenalidomide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "formestane", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "formestane may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Lanreotide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Lanreotide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "estramustine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "estramustine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ixabepilone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Ixabepilone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "testolactone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "testolactone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "mechlorethamine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "mechlorethamine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Olaparib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Olaparib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "methyltestosterone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "methyltestosterone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "fleroxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "fleroxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Trilostane", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Trilostane may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Vorinostat", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Vorinostat may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "temozolomide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "temozolomide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "5-azacytidine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "5-azacytidine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "TRIPTORELIN", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "TRIPTORELIN may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Erlotinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Erlotinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Degarelix", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Degarelix may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Midostaurin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Midostaurin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "moxifloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "mycophenolate mofetil", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "mycophenolate mofetil may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "diethylstilbestrol", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "diethylstilbestrol may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Axitinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Axitinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Trabectedin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Trabectedin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Venetoclax", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Venetoclax may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Romidepsin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Romidepsin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "plicamycin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "plicamycin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Trifluridine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Trifluridine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "LYCOPENE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "LYCOPENE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "suramin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "suramin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Axitinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Axitinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Dienogest", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Dienogest may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Decitabine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Decitabine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Olaparib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Olaparib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "daunorubicin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "daunorubicin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Cabozantinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Cabozantinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "rapamycin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "rapamycin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "HYDROXYPROGESTERONE CAPROATE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "LYCOPENE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "LYCOPENE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "hydroxyurea", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "hydroxyurea may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "pentostatin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "pentostatin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "etoposide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "etoposide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Gallium nitrate", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Gallium nitrate may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Imatinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Imatinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "floxuridine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "floxuridine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "teniposide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "teniposide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Trifluridine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Trifluridine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "temozolomide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "temozolomide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Gallium nitrate", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Gallium nitrate may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "ceritinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "ceritinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pralatrexate", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Pralatrexate may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "toremifene", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "toremifene may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Miltefosine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Miltefosine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "fleroxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "fleroxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Vismodegib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Vismodegib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Vinflunine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Vinflunine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Raltitrexed", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Raltitrexed may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "lomefloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "lomefloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "doxorubicin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "doxorubicin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "prednisone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "prednisone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Ecabet", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Ecabet may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "anagrelide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "formestane", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "formestane may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "podophyllotoxin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "podophyllotoxin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "streptozocin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "streptozocin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Romidepsin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Romidepsin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "daunorubicin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "daunorubicin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "prednisone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "prednisone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Besifloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Besifloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Trilostane", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Trilostane may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vorinostat", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Vorinostat may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Gallium nitrate", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Gallium nitrate may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Trifluridine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Trifluridine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "PHENYLACETIC ACID", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "PHENYLACETIC ACID may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "MEDROGESTONE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "MEDROGESTONE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "6-Mercaptopurine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "6-Mercaptopurine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "dexamethasone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "dexamethasone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "testolactone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "testolactone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "tibolone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "tibolone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "suramin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "suramin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "trimetrexate", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "trimetrexate may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "5-Aminolevulinic acid", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "5-Aminolevulinic acid may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Lenvatinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Vandetanib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "prednisone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "prednisone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Lapatinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Lapatinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "testolactone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "testolactone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "cytarabine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "cytarabine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Amrubicin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Amrubicin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "PAMIDRONIC ACID", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "PAMIDRONIC ACID may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Romidepsin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Romidepsin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "anagrelide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "HYDROXYPROGESTERONE CAPROATE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Dasatinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Dasatinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "arsenic trioxide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "lomefloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "lomefloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "enoxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "enoxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "moxifloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "oxaliplatin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "oxaliplatin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "cyclophosphamide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Bexarotene", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Bexarotene may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "cinoxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "cinoxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "retinol", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "retinol may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "mycophenolate mofetil", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "mycophenolate mofetil may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "RUCAPARIB", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "RUCAPARIB may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Sunitinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Sunitinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "dacarbazine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "dacarbazine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Carfilzomib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Carfilzomib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "enoxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "enoxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "goserelin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "goserelin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "ciprofloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "hydroxyurea", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "hydroxyurea may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Nilotinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pemetrexed", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Pemetrexed may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "tretinoin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "tretinoin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Lenalidomide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Lenalidomide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Masoprocol", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Masoprocol may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "mycophenolate mofetil", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "mycophenolate mofetil may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "floxuridine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "floxuridine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Axitinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Axitinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "dacarbazine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "dacarbazine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "carboplatin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "carboplatin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "VERTEPORFIN", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "VERTEPORFIN may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "letrozole", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "letrozole may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Belinostat", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Belinostat may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Vapreotide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Vapreotide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Vemurafenib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Vemurafenib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "vinblastine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "vinblastine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "ofloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "LYCOPENE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "LYCOPENE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mitomycin C", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "mitomycin C may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mycophenolate mofetil", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "mycophenolate mofetil may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "PONATINIB", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "PONATINIB may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pomalidomide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Pomalidomide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "retinol", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "retinol may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Pirlindole", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Pirlindole may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "5-azacytidine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "5-azacytidine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Clofarabine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Clofarabine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "melphalan", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "melphalan may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Gemifloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "sparfloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "sparfloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "letrozole", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "letrozole may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Idelalisib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Idelalisib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Sorafenib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Sorafenib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "temozolomide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "temozolomide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "EXEMESTANE", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "EXEMESTANE may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "lomustine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "lomustine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Fludarabine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Fludarabine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "diethylstilbestrol", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "diethylstilbestrol may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "hydroxyurea", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "hydroxyurea may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "mitoxantrone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "mitoxantrone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Eribulin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Eribulin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nintedanib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Nintedanib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "mycophenolic acid", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "mycophenolic acid may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "flutamide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "flutamide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "aminoglutethimide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "aminoglutethimide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "melphalan", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "melphalan may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "azelaic acid", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "azelaic acid may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Erlotinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Erlotinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "tegafur", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "tegafur may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "thalidomide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "thalidomide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "retinol", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "retinol may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Abiraterone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Abiraterone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "PHENYLACETIC ACID", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "PHENYLACETIC ACID may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Idelalisib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Idelalisib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "aminoglutethimide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "aminoglutethimide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "diethylstilbestrol", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "diethylstilbestrol may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "PIRFENIDONE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "PIRFENIDONE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "nalidixic acid", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "nalidixic acid may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Cladribine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Cladribine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Uramustine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Uramustine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "PHENYLACETIC ACID", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "PHENYLACETIC ACID may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "norfloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "norfloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "5-Aminolevulinic acid", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "5-Aminolevulinic acid may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Methyl aminolevulinate", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Methyl aminolevulinate may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Gatifloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Gatifloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "podophyllotoxin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "podophyllotoxin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Axitinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Axitinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Methyl aminolevulinate", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Methyl aminolevulinate may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Ruxolitinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Ruxolitinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "vinorelbine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "vinorelbine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Gatifloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Gatifloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "6-Mercaptopurine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "6-Mercaptopurine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "lomefloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "lomefloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Dienogest", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Dienogest may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "LYCOPENE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "LYCOPENE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Romidepsin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Romidepsin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "IMIQUIMOD", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "IMIQUIMOD may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Eribulin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Eribulin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "rapamycin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "rapamycin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "lomefloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "lomefloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Methyl aminolevulinate", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Methyl aminolevulinate may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ibrutinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Ibrutinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "thalidomide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "thalidomide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "trimetrexate", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "trimetrexate may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "RUCAPARIB", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "RUCAPARIB may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "tamoxifen", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "tamoxifen may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "RUCAPARIB", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "RUCAPARIB may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Decitabine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Decitabine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Calcipotriol", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Calcipotriol may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "cisplatin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "cisplatin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "5-Aminolevulinic acid", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "5-Aminolevulinic acid may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "MEDROGESTONE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "MEDROGESTONE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Trovafloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Trovafloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ruxolitinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Ruxolitinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "etoposide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "etoposide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "HYDROXYPROGESTERONE CAPROATE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "teniposide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "teniposide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "5-Fluorouracil", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "5-Fluorouracil may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "MEGESTROL ACETATE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "MEGESTROL ACETATE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Gatifloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Gatifloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "doxorubicin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "doxorubicin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "6-Mercaptopurine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "6-Mercaptopurine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "irinotecan", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "irinotecan may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "resveratrol", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "resveratrol may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "testolactone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "testolactone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "5-Fluorouracil", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "5-Fluorouracil may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Niraparib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Niraparib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Bosutinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Bosutinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "lomefloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "lomefloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Gallium nitrate", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Gallium nitrate may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Iobenguane", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Iobenguane may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Lapatinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Lapatinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "mitoxantrone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "mitoxantrone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Vandetanib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vapreotide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Vapreotide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Lenvatinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "vinblastine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "vinblastine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "CAPECITABINE", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "CAPECITABINE may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Vinflunine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Vinflunine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mitotane", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "mitotane may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Raltitrexed", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Raltitrexed may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "VERTEPORFIN", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "VERTEPORFIN may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "tamoxifen", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "tamoxifen may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Alitretinoin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Alitretinoin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "4-Methoxyphenol", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "4-Methoxyphenol may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "busulfan", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "busulfan may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Trabectedin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Trabectedin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "thioguanine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "thioguanine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Fulvestrant", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Fulvestrant may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Sorafenib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Sorafenib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "teniposide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "teniposide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "docetaxel", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "docetaxel may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Dabrafenib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Dabrafenib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "retinol", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "retinol may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "carmustine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "carmustine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pirlindole", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Pirlindole may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "albendazole", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "albendazole may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Valrubicin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Valrubicin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "vinblastine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "vinblastine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "carboplatin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "carboplatin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "TRIPTORELIN", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "TRIPTORELIN may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Erismodegib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Erismodegib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Erismodegib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Erismodegib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "thiotepa", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "thiotepa may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "gemcitabine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "gemcitabine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Ibrutinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Ibrutinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Fludarabine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Fludarabine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Gatifloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Gatifloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "chlorambucil", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "chlorambucil may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "cyclophosphamide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "carmustine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "carmustine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Gemifloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Gemifloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nelarabine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Nelarabine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "fleroxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "fleroxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Erismodegib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Erismodegib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "mebendazole", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "mebendazole may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mycophenolic acid", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "mycophenolic acid may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pemetrexed", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Pemetrexed may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "dacarbazine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "dacarbazine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Gefitinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Gefitinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "CYPROTERONE ACETATE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "thiotepa", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "thiotepa may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nelarabine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Nelarabine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Venetoclax", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Venetoclax may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Ibrutinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Ibrutinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "gemcitabine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "gemcitabine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "vinblastine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "vinblastine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "resveratrol", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "resveratrol may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "topotecan", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "topotecan may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "lomustine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "lomustine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Temsirolimus", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Temsirolimus may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "homoharringtonine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "homoharringtonine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "vincristine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "vincristine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "5-azacytidine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "5-azacytidine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Ibrutinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Ibrutinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "pipobroman", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "pipobroman may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "amsacrine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "amsacrine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "carmustine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "carmustine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "tibolone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "tibolone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "prednisone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "prednisone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Lenvatinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Lenvatinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Besifloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Besifloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "resveratrol", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "resveratrol may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Crizotinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "4-Methoxyphenol", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "4-Methoxyphenol may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "homoharringtonine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "homoharringtonine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Bortezomib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Bortezomib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "nilutamide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "nilutamide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Trametinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Trametinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Midostaurin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Midostaurin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "ofloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Bendamustine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Bendamustine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vinflunine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Vinflunine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Abiraterone", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Abiraterone may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cabergoline", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "cabergoline may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "dexamethasone", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "dexamethasone may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pixantrone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Pixantrone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Idelalisib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Idelalisib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "PIRFENIDONE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "PIRFENIDONE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "estramustine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "estramustine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Nedaplatin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Nedaplatin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "procarbazine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "procarbazine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Epirubicin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Epirubicin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Cabozantinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Cabozantinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Eribulin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Eribulin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Lanreotide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Lanreotide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "floxuridine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "floxuridine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "EXEMESTANE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "EXEMESTANE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "actinomycin D", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "actinomycin D may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "amsacrine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "amsacrine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "procarbazine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "procarbazine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "CYPROTERONE ACETATE", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "CYPROTERONE ACETATE may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Trilostane", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Trilostane may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Dabrafenib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Dabrafenib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "daunorubicin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "daunorubicin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "cisplatin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "cisplatin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "6-Mercaptopurine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "6-Mercaptopurine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Vandetanib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Vandetanib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Methyl aminolevulinate", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Methyl aminolevulinate may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "bicalutamide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "bicalutamide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Bosutinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Bosutinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Alitretinoin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Alitretinoin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Miltefosine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Miltefosine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "albendazole", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "albendazole may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "floxuridine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "floxuridine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Panobinostat may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "nilutamide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "nilutamide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "methyltestosterone", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "methyltestosterone may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "TEMOPORFIN", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "TEMOPORFIN may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Amrubicin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Amrubicin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Panobinostat may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pefloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Pefloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Trovafloxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Trovafloxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "nilutamide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "nilutamide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "irinotecan", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "irinotecan may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Temsirolimus", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Temsirolimus may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "goserelin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "goserelin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "IMIQUIMOD", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "IMIQUIMOD may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Sorafenib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Sorafenib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Niraparib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Niraparib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "cytarabine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "cytarabine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "EXEMESTANE", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "EXEMESTANE may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "osimertinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "osimertinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mechlorethamine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "mechlorethamine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "actinomycin D", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "actinomycin D may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Erlotinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Erlotinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "azathioprine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "azathioprine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "albendazole", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "albendazole may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mebendazole", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "mebendazole may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Belinostat", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Belinostat may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Bendamustine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Bendamustine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Dexrazoxane", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Dexrazoxane may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "4-PHENYLBUTYRIC ACID", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "4-PHENYLBUTYRIC ACID may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "cinoxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "cinoxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "bicalutamide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "bicalutamide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Crizotinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "mechlorethamine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "mechlorethamine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ruxolitinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Ruxolitinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Trametinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Trametinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Panobinostat may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pixantrone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Pixantrone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "nalidixic acid", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "nalidixic acid may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "resveratrol", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "resveratrol may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Dexrazoxane", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Dexrazoxane may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Lapatinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Lapatinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nedaplatin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Nedaplatin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "arsenic trioxide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Alitretinoin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Alitretinoin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "vindesine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "vindesine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "LEVOFLOXACIN may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "ofloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "aminoglutethimide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "aminoglutethimide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "anastrozole", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "anastrozole may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Pomalidomide", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Pomalidomide may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "thioguanine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "thioguanine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "ifosfamide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "ifosfamide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "VERTEPORFIN", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "VERTEPORFIN may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "methotrexate", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "methotrexate may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Crizotinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "docetaxel", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "docetaxel may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Sunitinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Sunitinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Vinflunine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Vinflunine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "vinorelbine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "vinorelbine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cabergoline", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "cabergoline may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "norfloxacin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "norfloxacin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "streptozocin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "streptozocin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "mitoxantrone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "mitoxantrone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Ecabet", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Ecabet may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Crizotinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Crizotinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "4-Methoxyphenol", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "4-Methoxyphenol may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Palbociclib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Palbociclib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "4-PHENYLBUTYRIC ACID", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "4-PHENYLBUTYRIC ACID may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Gefitinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Gefitinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "carmustine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "carmustine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Dabrafenib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Dabrafenib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "quinacrine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "quinacrine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Bortezomib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Bortezomib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Erismodegib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Erismodegib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Bexarotene", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Bexarotene may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "altretamine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "altretamine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "procarbazine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "procarbazine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "tegafur", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "tegafur may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Degarelix", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Degarelix may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Calcipotriol", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Calcipotriol may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Besifloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Besifloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Masoprocol", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Masoprocol may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "pipobroman", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "pipobroman may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Dexrazoxane", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Dexrazoxane may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "estramustine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "estramustine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "methylprednisolone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "methylprednisolone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Panobinostat", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Panobinostat may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Belinostat", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Belinostat may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Afatinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Afatinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Medroxyprogesterone acetate", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Medroxyprogesterone acetate may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "LEVOFLOXACIN may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "HYDROXYPROGESTERONE CAPROATE may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "mebendazole", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "mebendazole may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Uramustine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Uramustine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "cyclophosphamide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "cyclophosphamide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Cladribine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Cladribine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "anagrelide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "anagrelide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Imatinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Imatinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ixabepilone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Ixabepilone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "arsenic trioxide may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "rapamycin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "rapamycin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "PAMIDRONIC ACID", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "PAMIDRONIC ACID may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Temsirolimus", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Temsirolimus may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "nalidixic acid", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "nalidixic acid may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Radium-223 chloride", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Radium-223 chloride may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Fulvestrant", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Fulvestrant may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Sunitinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Sunitinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "5-Fluorouracil", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "5-Fluorouracil may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "mechlorethamine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "mechlorethamine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Decitabine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Decitabine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Clofarabine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Clofarabine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "teniposide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "teniposide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Ruxolitinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Ruxolitinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Vismodegib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Vismodegib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "tretinoin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "tretinoin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "MEGESTROL ACETATE", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "MEGESTROL ACETATE may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Ixabepilone", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Ixabepilone may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "amsacrine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "amsacrine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "bleomycin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "bleomycin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "ofloxacin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "ofloxacin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "pentostatin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "pentostatin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Pomalidomide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Pomalidomide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "quinacrine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "quinacrine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "thioguanine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "thioguanine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Gefitinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Gefitinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "procarbazine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "procarbazine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "lomustine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "lomustine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Pixantrone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Pixantrone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "melphalan", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "melphalan may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Clofarabine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Clofarabine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "colchicine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "colchicine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "methyltestosterone", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "methyltestosterone may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "moxifloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "moxifloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Pefloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Pefloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Octreotide", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Octreotide may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Vismodegib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Vismodegib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "cisplatin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "cisplatin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nedaplatin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Nedaplatin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "vindesine", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "vindesine may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "thiotepa", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "thiotepa may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "sparfloxacin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "sparfloxacin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "MEDROGESTONE", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "MEDROGESTONE may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Carfilzomib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Carfilzomib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "Nintedanib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Nintedanib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "podophyllotoxin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "podophyllotoxin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Afatinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Afatinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "actinomycin D", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "actinomycin D may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Pirlindole", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Pirlindole may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Imatinib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Imatinib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "osimertinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "osimertinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "arsenic trioxide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "arsenic trioxide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Nintedanib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Nintedanib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Valrubicin", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Valrubicin may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "Vismodegib", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "Vismodegib may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "vincristine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "vincristine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Pralatrexate", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Pralatrexate may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Raltitrexed", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Raltitrexed may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "nalidixic acid", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "nalidixic acid may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "bicalutamide", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "bicalutamide may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Trifluridine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "Trifluridine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "homoharringtonine", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "homoharringtonine may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Niraparib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Niraparib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "podophyllotoxin", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "podophyllotoxin may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "ceritinib", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "ceritinib may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "nalidixic acid", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "nalidixic acid may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "5-Aminolevulinic acid", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "5-Aminolevulinic acid may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "osimertinib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "osimertinib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Nilotinib", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "Nilotinib may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "altretamine", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "altretamine may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Vorinostat", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Vorinostat may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "suramin", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "suramin may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "Vismodegib", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "Vismodegib may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "IMIQUIMOD", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "IMIQUIMOD may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "TEMOPORFIN", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "TEMOPORFIN may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "ciprofloxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "ciprofloxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "doxorubicin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "doxorubicin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "LEVOFLOXACIN", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "LEVOFLOXACIN may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "Axitinib", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Axitinib may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "fleroxacin", "drug2": "digitoxin", "interaction_type": 58, "interaction_text": "fleroxacin may decrease the cardiotoxic activities of digitoxin.", "severity": 4}
{"drug1": "thalidomide", "drug2": "deslanoside", "interaction_type": 58, "interaction_text": "thalidomide may decrease the cardiotoxic activities of deslanoside.", "severity": 4}
{"drug1": "Bendamustine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "Bendamustine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "methotrexate", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "methotrexate may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "cinoxacin", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "cinoxacin may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "vincristine", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "vincristine may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "altretamine", "drug2": "ouabain", "interaction_type": 58, "interaction_text": "altretamine may decrease the cardiotoxic activities of ouabain.", "severity": 4}
{"drug1": "LYCOPENE", "drug2": "digoxin", "interaction_type": 58, "interaction_text": "LYCOPENE may decrease the cardiotoxic activities of digoxin.", "severity": 4}
{"drug1": "4-PHENYLBUTYRIC ACID", "drug2": "acetyldigitoxin", "interaction_type": 58, "interaction_text": "4-PHENYLBUTYRIC ACID may decrease the cardiotoxic activities of acetyldigitoxin.", "severity": 4}
{"drug1": "ipratropium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "ipratropium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "mecamylamine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "ATROPINE may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "oxybutynin may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "biperiden", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "biperiden may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "tubocurarine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "pirenzepine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Methylscopolamine bromide may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "benztropine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "benztropine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "ANISOTROPINE METHYLBROMIDE may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "orphenadrine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Fesoterodine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "procyclidine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "procyclidine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Metixene", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Metixene may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "quinidine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "quinidine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Atracurium besylate may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Tiotropium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "hyoscyamine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "propantheline", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "propantheline may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "tolterodine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "tolterodine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Pentolinium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "TRIMETHAPHAN may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "tropicamide", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "tropicamide may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "pancuronium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "pancuronium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "trihexyphenidyl may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "PIPECURONIUM may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Trospium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Trospium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "UMECLIDINIUM may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Aclidinium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Butylscopolamine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Desloratadine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "oxyphenonium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "dicyclomine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Propiverine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Propiverine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "ethopropazine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "scopolamine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "scopolamine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "Vecuronium may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "methscopolamine may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "potassium chloride", "interaction_type": 59, "interaction_text": "cyclopentolate may increase the ulcerogenic activities of potassium chloride.", "severity": 2}
{"drug1": "procarbazine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "losartan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "primidone", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "Sapropterin", "drug2": "Udenafil", "interaction_type": 60, "interaction_text": "Sapropterin may increase the hypotensive activities of Udenafil.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "methyldopa", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "timolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Carbetocin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Carbetocin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "pargyline", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "benazepril", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "bepridil", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "molsidomine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Rotigotine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Rotigotine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "thiopental", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "indapamide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "quinapril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "sevoflurane may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "indapamide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "atenolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "labetalol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Spirapril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "nifedipine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "tolazoline", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "prazosin", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Travoprost", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "cilazapril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "REMIFENTANIL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of REMIFENTANIL.", "severity": 2}
{"drug1": "thiopental", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "moclobemide", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "diazoxide", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "isradipine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "procarbazine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "propofol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of propofol.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "manidipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "hydralazine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "alprenolol", "drug2": "captopril", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "alprenolol", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "losartan", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Travoprost", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "levorphanol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of levorphanol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "timolol", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "fosinopril", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "propranolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "methylene blue", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "nadolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "indapamide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "promethazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "periciazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "captopril", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "propranolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "timolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "irbesartan", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "labetalol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "selegiline", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "propranolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "tolfenamic acid may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "timolol", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "guanabenz", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "clonidine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "VERAPAMIL may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "tolazoline", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "promethazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Levobupivacaine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Bosentan", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "methylene blue", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Bosentan", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "latanoprost", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "pargyline", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "labetalol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "labetalol", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Quinine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "DESERPIDINE may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "valsartan", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "SUFENTANIL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of SUFENTANIL.", "severity": 2}
{"drug1": "clonidine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Ambrisentan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Ambrisentan may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "procarbazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "thiopental", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "selegiline", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Quinine", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Amrinone", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Amrinone may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "labetalol", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "nifedipine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "ESMOLOL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Ketobemidone", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Ketobemidone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "primidone", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "isradipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "Travoprost", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "codeine", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of codeine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "quinidine", "drug2": "VERAPAMIL", "interaction_type": 60, "interaction_text": "quinidine may increase the hypotensive activities of VERAPAMIL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "periciazine", "drug2": "HEROIN", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of HEROIN.", "severity": 2}
{"drug1": "indapamide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "oxymorphone", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of oxymorphone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Bosentan", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Quinine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "losartan", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "VERAPAMIL may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "rasagiline", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Torasemide", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "losartan", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Torasemide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "promazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "felodipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "molsidomine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "thiamylal", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "primidone", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "practolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "propranolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "moclobemide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "furosemide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "furosemide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "pargyline", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "penbutolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "tolazoline", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "primidone", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "primidone", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "timolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "prazosin", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Sacubitril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "bumetanide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Pentyl nitrite may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "timolol", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "procarbazine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "reserpine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "benazepril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "manidipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "quetiapine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "quetiapine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "primidone", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "captopril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "minoxidil", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "minoxidil", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "periciazine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "timolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "terazosin", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "thiopental", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "periciazine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "losartan", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Travoprost", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "DIHYDROCODEINE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Silodosin", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "benazepril", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "latanoprost", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "pargyline", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "METYROSINE may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "minoxidil", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "ramipril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "procarbazine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "rescinnamine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "labetalol", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "selegiline", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "thiopental", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pargyline", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "isradipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "quinapril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "quinapril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "labetalol", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "flunarizine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "cilnidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "hydromorphone", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of hydromorphone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "methyclothiazide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "valsartan", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "metoprolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "quinapril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "Quinine", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "betaxolol", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Quinine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "pargyline", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "diazoxide", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "METYROSINE may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "periciazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "REMIFENTANIL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of REMIFENTANIL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "primidone", "drug2": "timolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Ethylmorphine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Ethylmorphine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "captopril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "indapamide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "pargyline", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "thiopental", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "rescinnamine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "rescinnamine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "ramipril", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "prazosin", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "primidone", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "hydralazine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "pargyline", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "pargyline", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "methyldopa", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "prazosin", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "timolol", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "timolol", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "captopril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "propranolol", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "reserpine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "pargyline", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "nadolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "bepridil", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "minoxidil", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "morphine", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of morphine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "imipramine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "DEZOCINE", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of DEZOCINE.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "alprenolol", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "nifedipine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "valsartan", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "terazosin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "periciazine", "drug2": "DIHYDROCODEINE", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "quinapril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "atenolol", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "furazolidone", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "doxazosin", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "quetiapine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of quetiapine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "DEXMEDETOMIDINE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "VERAPAMIL may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "secobarbital", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "captopril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "valsartan", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "terazosin", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "alfuzosin", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "selegiline", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "primidone", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "ramipril", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "polythiazide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "metolazone", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Conivaptan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Conivaptan.", "severity": 2}
{"drug1": "carvedilol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "carvedilol", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "procarbazine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Bretylium", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "selegiline", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "promazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "betaxolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "nifedipine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "PENTAERYTHRITOL TETRANITRATE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "manidipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "manidipine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "indapamide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "secobarbital", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "methylene blue", "drug2": "HEROIN", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of HEROIN.", "severity": 2}
{"drug1": "fosinopril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "clonidine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Quinine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "levorphanol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of levorphanol.", "severity": 2}
{"drug1": "thiopental", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Quinine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Remikiren", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "isradipine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "valsartan", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Spirapril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "nicardipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "molsidomine", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "brimonidine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "brimonidine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "promazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "promazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "pargyline", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "diazoxide", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "selegiline", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "atenolol", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "latanoprost", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "latanoprost", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "valsartan", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "methyclothiazide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Riociguat may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "clonidine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "ramipril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "quetiapine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of quetiapine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "promethazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "trandolapril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "promethazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Remikiren", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "clonidine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "isradipine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "isradipine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "furazolidone", "drug2": "timolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "METYROSINE may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "captopril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "periciazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "indapamide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "diazoxide", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "metoprolol", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "dichlorphenamide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "moclobemide", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "nadolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "furazolidone", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "molsidomine", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Udenafil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Udenafil.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "captopril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "trandolapril", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "clonidine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "propoxyphene", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of propoxyphene.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "selegiline", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "timolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "ramipril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "prazosin", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "tolazoline", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "tolazoline", "drug2": "captopril", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "amoxapine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "amoxapine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "sotalol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "sotalol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "REMIFENTANIL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of REMIFENTANIL.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "primidone", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "selegiline", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "alprenolol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "propranolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "reserpine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Tolcapone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Tolcapone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "diltiazem", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "tolazoline", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "REMIFENTANIL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of REMIFENTANIL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "captopril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Quinine", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Bortezomib", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Bortezomib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "felodipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Travoprost", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Ethylmorphine", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Ethylmorphine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "thiopental", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "periciazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "benazepril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "losartan", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "valsartan", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "primidone", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "bepridil", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "bepridil", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "bepridil", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "clonidine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "pargyline", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "molsidomine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "cilazapril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Travoprost", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "VERAPAMIL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of VERAPAMIL.", "severity": 2}
{"drug1": "reserpine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "captopril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "procarbazine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "pargyline", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "atenolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "molsidomine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "captopril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "diltiazem", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "indapamide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Travoprost", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "felodipine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "timolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "pargyline", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "labetalol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "reserpine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of reserpine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "atenolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "timolol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "manidipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Eplerenone may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "prazosin", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "phentolamine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "hydralazine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Pentyl nitrite", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Pentyl nitrite may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "thiopental", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "prazosin", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "DESERPIDINE may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Remikiren", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "captopril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "nicardipine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "captopril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "captopril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "nicardipine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "dipyridamole may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "trandolapril", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "ethanol", "drug2": "sildenafil", "interaction_type": 60, "interaction_text": "ethanol may increase the hypotensive activities of sildenafil.", "severity": 2}
{"drug1": "moclobemide", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "isradipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "atenolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "primidone", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "rasagiline", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "dyphylline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "primidone", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "selegiline", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "primidone", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "primidone", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "primidone", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "propranolol", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "furazolidone", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "primidone", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "felodipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "reserpine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "amobarbital", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "isradipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "nicardipine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "primidone", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "buprenorphine", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of buprenorphine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "nicardipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "valsartan", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "metolazone", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "ETHACRYNIC ACID may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "diazoxide", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "timolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "indapamide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "labetalol", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "losartan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "thiopental", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "diazoxide", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "timolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "DESERPIDINE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "timolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "DESERPIDINE may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "pargyline", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "losartan", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "phentolamine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "phentolamine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "cinnarizine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "ramipril", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Quinine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "felodipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "nadolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "pentazocine", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of pentazocine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "pargyline", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "quinapril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "alprenolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "isradipine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "pargyline", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "molsidomine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "promazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "indapamide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "fosinopril", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "quinapril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "enalapril", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "guanabenz", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Travoprost", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "barnidipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "barnidipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "felodipine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "labetalol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "isoflurane", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "isoflurane may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "DIPHENOXYLATE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "captopril", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "oxymorphone", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of oxymorphone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Quinine", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Quinine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "methadone", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of methadone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "amobarbital", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "prazosin", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Travoprost", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "metolazone", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Quinine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "nadolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "procarbazine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "procarbazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "prazosin", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Bortezomib may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "selegiline", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "nicardipine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "captopril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "captopril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "reserpine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "timolol", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "clozapine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of clozapine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Ethylmorphine", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Ethylmorphine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "phentolamine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "labetalol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "Travoprost", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "propranolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Remikiren", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "timolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "thiopental", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "thiopental", "drug2": "Bortezomib", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Bortezomib.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "molsidomine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Tolcapone", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Tolcapone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Methadyl acetate", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Methadyl acetate.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "quinapril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "primidone", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "propranolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "spironolactone", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "spironolactone may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "timolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Normethadone", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Normethadone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "enalapril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "metolazone", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "furazolidone", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "penbutolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "promethazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "theophylline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "practolol", "interaction_type": 60, "interaction_text": "VERAPAMIL may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "metolazone", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "nadolol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Sitaxsentan may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "diltiazem", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "propranolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "molsidomine", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "primidone", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "ramipril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "phentolamine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "losartan", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "reserpine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of reserpine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "alfuzosin", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "isradipine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "molsidomine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "periciazine", "drug2": "propoxyphene", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of propoxyphene.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "ERYTHRITYL TETRANITRATE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of ERYTHRITYL TETRANITRATE.", "severity": 2}
{"drug1": "clonidine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "felodipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "carvedilol", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "methylene blue", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Quinine", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "amobarbital", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "Quinine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "labetalol", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "codeine", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of codeine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "hydralazine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "dolasetron may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "nalbuphine", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of nalbuphine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "thiopental", "drug2": "timolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "procarbazine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Benidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Benidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "enalapril", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "tolazoline", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "latanoprost", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "thiopental", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "tolazoline", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "thiopental", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "thiopental", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "captopril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "tibolone", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "polythiazide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "ramipril", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "prazosin", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "isradipine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "tolazoline", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "primidone", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "periciazine", "drug2": "SUFENTANIL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of SUFENTANIL.", "severity": 2}
{"drug1": "thiopental", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "enalapril", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "penbutolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "valsartan", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "nifedipine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Ropivacaine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "furazolidone", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "furazolidone", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "pargyline", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "pargyline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "sildenafil", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "timolol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "timolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "procarbazine", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "cilazapril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "furazolidone", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "furazolidone", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "diazoxide", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "ETHACRYNIC ACID may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "ramipril", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "isradipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "quinapril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "primidone", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "captopril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "quinapril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "fosinopril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Travoprost", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "losartan", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "guanabenz", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Quinine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "captopril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "moclobemide", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "perphenazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "moclobemide", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "oxycodone", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of oxycodone.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "VERAPAMIL may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "valsartan", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Apremilast may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Remikiren", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "periciazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "thiopental", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "losartan", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "lisinopril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "selegiline", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "reserpine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "hydralazine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Tramadol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Tramadol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "atenolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "VERAPAMIL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of VERAPAMIL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "primidone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "clomipramine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "clomipramine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "nifedipine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Normethadone", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Normethadone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "selegiline", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Tolcapone may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "Quinine", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "tropisetron", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "tropisetron may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "propofol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of propofol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "SUFENTANIL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of SUFENTANIL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Travoprost", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "diazoxide", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "HEROIN", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of HEROIN.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "tolazoline", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "levorphanol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of levorphanol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "molsidomine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "molsidomine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Conivaptan", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Conivaptan.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "tolazoline", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Torasemide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "Remikiren", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "triamterene", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "triamterene may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "labetalol", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Bosentan", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Travoprost", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "timolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Sitaxsentan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "bepridil", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Bretylium", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "pentazocine", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of pentazocine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "phentolamine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Nabilone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Nabilone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "quinapril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "polythiazide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "phentolamine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "pargyline", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "pargyline", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "phentolamine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "pargyline", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Pregabalin may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "terazosin", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "butorphanol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of butorphanol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "terazosin", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "molsidomine", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "felodipine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "bepridil", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "losartan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Sitaxsentan may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "thiamylal", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "clonidine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "HYDROCODONE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of HYDROCODONE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "brimonidine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "VERAPAMIL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of VERAPAMIL.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "butorphanol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of butorphanol.", "severity": 2}
{"drug1": "Quinine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "ALFENTANIL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of ALFENTANIL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "losartan", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "promethazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "rasagiline", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "thiopental", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "reserpine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of reserpine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "latanoprost", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "pargyline", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "captopril", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "pargyline", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "metolazone", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "prazosin", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "methyldopa", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "promethazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "selegiline", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "timolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "timolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "timolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "methyclothiazide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "selegiline", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "quinapril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "reserpine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "reserpine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "clonidine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Travoprost", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "furazolidone", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "enalapril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "labetalol", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "molsidomine", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "nadolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "perphenazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "losartan", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "diltiazem", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "isradipine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Methadyl acetate", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Methadyl acetate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "primidone", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Spirapril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "selegiline", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "amobarbital", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "thiopental", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "prazosin", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Quinine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "SUFENTANIL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of SUFENTANIL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "felodipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "molsidomine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "acebutolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "primidone", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "granisetron", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "granisetron may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pargyline", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "latanoprost", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "phentolamine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "reserpine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of reserpine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "methyldopa", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "periciazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "thiopental", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "lisinopril", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "valsartan", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "Travoprost", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "fosinopril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "apraclonidine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Quinine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Quinine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "Quinine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Ketobemidone", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Ketobemidone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "benazepril", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "primidone", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "indapamide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "thiopental", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "METYROSINE may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "METYROSINE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "timolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "HYDROCODONE", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of HYDROCODONE.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "alprenolol", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "betaxolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "metolazone", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "LEVOBUNOLOL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "thiopental", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "lisinopril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "quinapril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "manidipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "clonidine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "promazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Dapagliflozin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "metolazone", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "felodipine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "thiopental", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "enalapril", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Remikiren", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "irbesartan", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "reserpine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "primidone", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "primidone", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "thioridazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "primidone", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Riociguat may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "barnidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "nifedipine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "acebutolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "clonidine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "ramipril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "losartan", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "furazolidone", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "amobarbital", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Remikiren", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "primidone", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "primidone", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "primidone", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "primidone", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Remikiren", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "thiopental", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "indapamide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "captopril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Tadalafil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Tadalafil.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "butorphanol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of butorphanol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "latanoprost", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "ramipril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Quinine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "captopril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "ropinirole", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of ropinirole.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "Quinine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "irbesartan", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "bepridil", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "betaxolol", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "manidipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "terazosin", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "perphenazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "benazepril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "furazolidone", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "furazolidone", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Quinine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "perphenazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "codeine", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of codeine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Silodosin", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "pentazocine", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of pentazocine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "doxazosin", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "amphotericin b may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "periciazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "bepridil", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "valsartan", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Travoprost", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "cilazapril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "DIPHENOXYLATE", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "periciazine", "drug2": "oxymorphone", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of oxymorphone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Silodosin", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "atenolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "tolazoline", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "lisinopril", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "captopril", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "promethazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Quinine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "morphine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "morphine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Quinine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Quinine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "prazosin", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "felodipine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "molsidomine", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "valsartan", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "captopril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "isradipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "clonidine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Quinine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Bretylium", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "tibolone", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "clonidine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "bepridil", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "timolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "felodipine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "tibolone", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "primidone", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "procarbazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "molsidomine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "selegiline", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "thiopental", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Quinine", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "bepridil", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "atenolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "losartan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Quinine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "metolazone", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Quinine", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "quinapril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "prazosin", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Conivaptan may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "molsidomine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "selegiline", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "enalapril", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "ramipril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "ramipril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "timolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "enalapril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "enalapril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "pargyline", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "phentolamine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "nadolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "ethanol", "drug2": "Udenafil", "interaction_type": 60, "interaction_text": "ethanol may increase the hypotensive activities of Udenafil.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Normethadone", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Normethadone.", "severity": 2}
{"drug1": "labetalol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "pargyline", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "thiamylal", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "pargyline", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "guanabenz", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "perphenazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "pargyline", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "timolol", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "felodipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "amiodarone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of amiodarone.", "severity": 2}
{"drug1": "atenolol", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "alfuzosin", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "periciazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "periciazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "ramipril", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "molsidomine", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "furazolidone", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "codeine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of codeine.", "severity": 2}
{"drug1": "primidone", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "periciazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "timolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Ketobemidone", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Ketobemidone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "losartan", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Lurasidone", "interaction_type": 60, "interaction_text": "epinephrine may increase the hypotensive activities of Lurasidone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "amifostine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "amifostine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "nadolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "DEZOCINE", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of DEZOCINE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "nicardipine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "rasagiline", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "ramipril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "VERAPAMIL may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "selegiline", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "tibolone", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "tibolone", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "tolazoline", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "nadolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "benazepril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "moclobemide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "LEVOSIMENDAN", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "LEVOSIMENDAN may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "thiopental", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "thiopental", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "thiopental", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "enalapril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "terazosin", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "periciazine", "drug2": "morphine", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of morphine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Avanafil", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "metolazone", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "minoxidil", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "molsidomine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Ketobemidone", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Ketobemidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Tapentadol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Tapentadol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "methyclothiazide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "furazolidone", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "amobarbital", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "Quinine", "drug2": "reserpine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of reserpine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "bupivacaine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "dipyridamole may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "indapamide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "bepridil", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Quinine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "primidone", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "indapamide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "primidone", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "selegiline", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "selegiline", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "losartan", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "MAGNESIUM SULFATE may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Vardenafil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Vardenafil.", "severity": 2}
{"drug1": "labetalol", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Quinine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "tizanidine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "REMIFENTANIL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "primidone", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "promazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "primidone", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "phentolamine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "phentolamine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "diazoxide", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "diazoxide", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "primidone", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "pargyline", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "guanabenz", "drug2": "captopril", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "thiamylal", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "doxazosin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "pargyline", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Roflumilast may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "nadolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "hydralazine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Quinine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "protriptyline", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "protriptyline may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "ALFENTANIL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of ALFENTANIL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "guanabenz", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "methylene blue", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "primidone", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "thiopental", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "timolol", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "aminophylline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Bosentan", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "periciazine", "drug2": "buprenorphine", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of buprenorphine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "losartan", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "prazosin", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "prazosin", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "carvedilol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "reserpine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Bretylium", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "clonidine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "nifedipine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "anagrelide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "atenolol", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "tibolone", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "terazosin", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "pargyline", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "pargyline", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "pargyline", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "promazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "procarbazine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "primidone", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "reserpine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "indapamide", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "indapamide", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "indapamide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "benazepril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Bretylium", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "Canagliflozin may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Quinine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "losartan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "primidone", "drug2": "captopril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "primidone", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "clonidine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "Quinine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "propranolol", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Silodosin", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Remikiren", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "valsartan", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "valsartan", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "tibolone", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "primidone", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "doxazosin", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "ETHACRYNIC ACID may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "indapamide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "tretinoin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Travoprost", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Udenafil", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "nicardipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "thiopental", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "thiopental", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "atenolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "atenolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "tranylcypromine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of tranylcypromine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "isoflurane", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of isoflurane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "valsartan", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "tolazoline", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "captopril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "benazepril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "periciazine", "drug2": "levorphanol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of levorphanol.", "severity": 2}
{"drug1": "thiopental", "drug2": "captopril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "ramipril", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Clofarabine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "captopril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "hydromorphone", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of hydromorphone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "halothane", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of halothane.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "valsartan", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Bretylium", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "PERHEXILINE may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "selegiline", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "celiprolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "rasagiline", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "benazepril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "periciazine", "drug2": "Ethylmorphine", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Ethylmorphine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "valsartan", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "molsidomine", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of PENTAERYTHRITOL TETRANITRATE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "losartan", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "DIPHENOXYLATE", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "nimodipine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "furosemide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "furosemide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "thiopental", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "thiopental", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "bepridil", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "prazosin", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "reserpine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Quinine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Quinine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "reserpine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "phentolamine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "promethazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "primidone", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "thiopental", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "prazosin", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "bepridil", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "pargyline", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "timolol", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Conivaptan", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Conivaptan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "latanoprost", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "bepridil", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "reserpine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "alprenolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "DESFLURANE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of DESFLURANE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "practolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Remikiren", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "minoxidil", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "propranolol", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "prazosin", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "amitriptyline may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "thiopental", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "thiopental", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "thiopental", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "valsartan", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Dothiepin may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "valsartan", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "thiopental", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "thiopental", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "prazosin", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "furosemide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "furosemide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "selegiline", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "thiopental", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "meperidine", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of meperidine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Normethadone", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Normethadone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "selegiline", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "nortriptyline may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Torasemide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "metolazone", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "lisinopril", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Avanafil", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "primidone", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "ramipril", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "ramipril", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "guanabenz", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "bepridil", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "DESFLURANE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of DESFLURANE.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "nalbuphine", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of nalbuphine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "manidipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "propranolol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Conivaptan", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Conivaptan.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Tapentadol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Tapentadol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "molsidomine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Clevidipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "ALFENTANIL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of ALFENTANIL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "timolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Torasemide", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Remikiren", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Remikiren", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "timolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "diazoxide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "HYDROCODONE", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of HYDROCODONE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "ramipril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "captopril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "trandolapril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "pargyline", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "nadolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "enalapril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "mirtazapine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "prazosin", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "pargyline", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "bepridil", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "pargyline", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "enalapril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Sapropterin", "drug2": "Avanafil", "interaction_type": 60, "interaction_text": "Sapropterin may increase the hypotensive activities of Avanafil.", "severity": 2}
{"drug1": "bepridil", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "metolazone", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "selegiline", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "atenolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "felodipine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "felodipine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "minoxidil", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "periciazine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "reserpine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "thiopental", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "Quinine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "lisinopril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "secobarbital", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "periciazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "valsartan", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "furazolidone", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "betaxolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Tapentadol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Tapentadol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "nimodipine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "pargyline", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "bepridil", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "minoxidil", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "pargyline", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "periciazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "metolazone", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "diazoxide", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nitric oxide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "penbutolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "nicardipine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "papaverine", "drug2": "levodopa", "interaction_type": 60, "interaction_text": "papaverine may increase the hypotensive activities of levodopa.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "methazolamide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "methazolamide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "prazosin", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "thiopental", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Macitentan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Macitentan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "nadolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "indapamide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "captopril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "pargyline", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "felodipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "METYROSINE may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "labetalol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "codeine", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of codeine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "tolazoline", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "felodipine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "prazosin", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "isradipine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Conivaptan", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Conivaptan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "losartan", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Remikiren", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "losartan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "molsidomine", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "periciazine", "drug2": "Normethadone", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Normethadone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Bosentan", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "timolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "pargyline", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "selegiline", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "cilnidipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "propranolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "clonidine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "enalapril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "alprenolol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "selegiline", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Quinine", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "thiopental", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "Quinine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "hydralazine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "thiopental", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "thiopental", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "timolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "ERYTHRITYL TETRANITRATE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "ERYTHRITYL TETRANITRATE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "guanabenz", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "sevoflurane", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of sevoflurane.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "levodopa", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of levodopa.", "severity": 2}
{"drug1": "indapamide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "latanoprost", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "propranolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "atenolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "butorphanol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of butorphanol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "prazosin", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "quinapril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "tolazoline", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "periciazine", "drug2": "nalbuphine", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of nalbuphine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "doxazosin", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Bosentan", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "selegiline", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "primidone", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "felodipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "secobarbital", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "thiopental", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "thiopental", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "nimodipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "cyclobenzaprine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "perphenazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "carvedilol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "metolazone", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "indapamide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "labetalol", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "labetalol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "thiamylal", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "hydralazine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "promazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "promazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "papaverine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "papaverine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Levobupivacaine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Levobupivacaine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "methadone", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of methadone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Methadyl acetate", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Methadyl acetate.", "severity": 2}
{"drug1": "latanoprost", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "doxazosin", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "furazolidone", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "terazosin", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "Sapropterin", "drug2": "Tadalafil", "interaction_type": 60, "interaction_text": "Sapropterin may increase the hypotensive activities of Tadalafil.", "severity": 2}
{"drug1": "irbesartan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Quinine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "Quinine", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Bosentan", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "phentolamine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Quinine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "losartan", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "thiopental", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "furazolidone", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "primidone", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "promethazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "isradipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "tibolone", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "nadolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "losartan", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "nicardipine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "molsidomine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "metolazone", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "metolazone", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "pargyline", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "cilazapril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "perphenazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "molsidomine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "enalapril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "tizanidine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of tizanidine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "prazosin", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "methyldopa", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "prazosin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "tolazoline", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "thiamylal", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "reserpine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "Palonosetron may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "captopril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "thiamylal", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "promazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "captopril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "bepridil", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "celiprolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Travoprost", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "labetalol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "ramipril", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "morphine", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of morphine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "bepridil", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "atenolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "periciazine", "drug2": "oxycodone", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of oxycodone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Ropivacaine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Ropivacaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "bupivacaine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of bupivacaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "morphine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of morphine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "furazolidone", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "methylene blue", "drug2": "losartan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "thiopental", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Pipamperone", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Pipamperone may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "terazosin", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "isradipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "losartan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "reserpine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "reserpine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "diazoxide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pargyline", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "losartan", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "isradipine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "enalapril", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "primidone", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "hydralazine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Conivaptan", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Conivaptan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "reserpine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "prazosin", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "reserpine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of reserpine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "periciazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "irbesartan", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "periciazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "Quinine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "benazepril", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "isradipine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "metolazone", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "tibolone", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "procarbazine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "indapamide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "molsidomine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "indapamide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "DESERPIDINE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "primidone", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "latanoprost", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "latanoprost", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "nifedipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "clonidine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "felodipine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "terazosin", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "alprenolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "nimodipine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "rasagiline", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "molsidomine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "thiopental", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "nimodipine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "VERAPAMIL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of VERAPAMIL.", "severity": 2}
{"drug1": "Remikiren", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "periciazine", "drug2": "DEZOCINE", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of DEZOCINE.", "severity": 2}
{"drug1": "terazosin", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "terazosin", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "promethazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "practolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "indapamide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "alprenolol", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "enalapril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "timolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "reserpine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "thioridazine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of thioridazine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "losartan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "captopril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "promethazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "pramipexole", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of pramipexole.", "severity": 2}
{"drug1": "metolazone", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "pargyline", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "pargyline", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "propofol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "propofol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "atenolol", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "levodopa", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of levodopa.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "sevoflurane", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of sevoflurane.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "ethanol", "drug2": "Tadalafil", "interaction_type": 60, "interaction_text": "ethanol may increase the hypotensive activities of Tadalafil.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "ramipril", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "latanoprost", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "furazolidone", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "timolol", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "enalapril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "periciazine", "drug2": "Ketobemidone", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Ketobemidone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "tibolone", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "periciazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "periciazine", "drug2": "butorphanol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of butorphanol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "timolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "timolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "molsidomine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "promethazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "promethazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "ALFENTANIL", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of ALFENTANIL.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "pentazocine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of pentazocine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "thiopental", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "doxazosin", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "REMIFENTANIL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of REMIFENTANIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "Quinine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "reserpine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "hydralazine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "quinapril", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "diazoxide", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "diazoxide", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Flibanserin", "interaction_type": 60, "interaction_text": "ethanol may increase the hypotensive activities of Flibanserin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "nadolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "benazepril", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "primidone", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Quinine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "metolazone", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "propranolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Silodosin", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "SUFENTANIL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "SUFENTANIL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of SUFENTANIL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "promazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Bretylium", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Bosentan", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "terazosin", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "meperidine", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of meperidine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Silodosin", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of Silodosin.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "periciazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "primidone", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Sapropterin", "drug2": "Vardenafil", "interaction_type": 60, "interaction_text": "Sapropterin may increase the hypotensive activities of Vardenafil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "thiopental", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "selegiline", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "HYDROCODONE", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of HYDROCODONE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "thiopental", "drug2": "VERAPAMIL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of VERAPAMIL.", "severity": 2}
{"drug1": "propranolol", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "amobarbital", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "atenolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "imipramine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "imipramine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "furazolidone", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "benazepril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nalbuphine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of nalbuphine.", "severity": 2}
{"drug1": "primidone", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "promethazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "rasagiline", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "rasagiline", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "cilazapril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "oxymorphone", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of oxymorphone.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "pargyline", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "valsartan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "prazosin", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Udenafil", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "periciazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "metolazone", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "isradipine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "ramipril", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "NITROUS ACID", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "NITROUS ACID may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "prazosin", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "pargyline", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "propoxyphene", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of propoxyphene.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "pargyline", "drug2": "captopril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "metolazone", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "guanabenz", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "guanabenz", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "losartan", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "ondansetron", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "ondansetron may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "dichlorphenamide", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of dichlorphenamide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "thiopental", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "latanoprost", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "latanoprost", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "thiamylal", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "irbesartan", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Avanafil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Avanafil.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "DIHYDROCODEINE", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "ramipril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Spirapril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "selegiline", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "betaxolol", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Canagliflozin may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "thiopental", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "diazoxide", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "benazepril", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "captopril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "oxycodone", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of oxycodone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "metolazone", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "captopril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "procarbazine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Bosentan", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "captopril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "pargyline", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "procarbazine", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "latanoprost", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "metolazone", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "methyclothiazide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "reserpine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Bortezomib", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Bortezomib.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "HEROIN", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of HEROIN.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "benazepril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "guanabenz", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "enalapril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "propranolol", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Levobupivacaine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Levobupivacaine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "HEROIN", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of HEROIN.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "tizanidine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "Remikiren", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Sitaxsentan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "valsartan", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "losartan", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "labetalol", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Torasemide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "primidone", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "latanoprost", "drug2": "losartan", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "labetalol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Travoprost", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "ISOSORBIDE DINITRATE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "diazoxide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "ALFENTANIL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of ALFENTANIL.", "severity": 2}
{"drug1": "atenolol", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "periciazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "DEXMEDETOMIDINE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "pargyline", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "pargyline", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Bortezomib", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Bortezomib.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "bumetanide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "rasagiline", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Bretylium", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "clozapine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "clozapine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "molsidomine", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "molsidomine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "manidipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "ethanol", "drug2": "Vardenafil", "interaction_type": 60, "interaction_text": "ethanol may increase the hypotensive activities of Vardenafil.", "severity": 2}
{"drug1": "quinapril", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "labetalol", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "guanabenz", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "selegiline", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Travoprost", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "captopril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "secobarbital", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "periciazine", "drug2": "pentazocine", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of pentazocine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "enalapril", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "nimodipine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "buprenorphine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of buprenorphine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "DOXOFYLLINE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "DOXOFYLLINE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "rasagiline", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "thioridazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Udenafil", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "hydromorphone", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of hydromorphone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Quinine", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "levorphanol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of levorphanol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "oxycodone", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of oxycodone.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "bepridil", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "trandolapril", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "isradipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "furazolidone", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "latanoprost", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "captopril", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "bumetanide", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of bumetanide.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "pargyline", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "tibolone", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Canagliflozin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Canagliflozin.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "tibolone", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Tianeptine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "timolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "clomipramine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "promazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "promazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "promazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "isradipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "valsartan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "reserpine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "quinapril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "timolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "AMILORIDE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "methyldopa", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "rescinnamine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "felodipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "minoxidil", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "captopril", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "minoxidil", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Torasemide", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "polythiazide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "doxepin", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "doxepin may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "thiopental", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "furazolidone", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "benazepril", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "dopamine", "drug2": "Lurasidone", "interaction_type": 60, "interaction_text": "dopamine may increase the hypotensive activities of Lurasidone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "benazepril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "primidone", "drug2": "dipyridamole", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of dipyridamole.", "severity": 2}
{"drug1": "alprenolol", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "terazosin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "nadolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "latanoprost", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Bretylium", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "selegiline", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "selegiline", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "propranolol", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "metolazone", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "primidone", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "thiamylal", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Quinine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "selegiline", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "metolazone", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "latanoprost", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Udenafil", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "prazosin", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Risedronic acid may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "labetalol", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "atenolol", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "atenolol", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "primidone", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "reserpine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "terazosin", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "reserpine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Azelnidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "DIHYDROCODEINE", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "Travoprost", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "latanoprost", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "minoxidil", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "amobarbital", "drug2": "timolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "thiamylal", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Ambrisentan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "methazolamide", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of methazolamide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "timolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "captopril", "interaction_type": 60, "interaction_text": "QUINETHAZONE may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "diltiazem", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "valsartan", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Quinine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "thiopental", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "prazosin", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "captopril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "promethazine", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "propranolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "moclobemide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "propranolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "enalapril", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "selegiline", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "felodipine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "prazosin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "nadolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "enalapril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "selegiline", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "prazosin", "drug2": "tolfenamic acid", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of tolfenamic acid.", "severity": 2}
{"drug1": "quinapril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "propofol", "interaction_type": 60, "interaction_text": "Rifampicin may increase the hypotensive activities of propofol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "atenolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "selegiline", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "propranolol", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "tolazoline", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "methyldopa", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "nitroglycerin may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "practolol", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "thiopental", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "alprenolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Pipamperone", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Pipamperone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "thalidomide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of thalidomide.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "DIPHENOXYLATE", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "betaxolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "methylene blue", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "captopril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "minoxidil", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "acebutolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "furazolidone", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "thiopental", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "primidone", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "diltiazem", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "Remikiren", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Travoprost", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Ethylmorphine", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Ethylmorphine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pargyline", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "nalbuphine", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of nalbuphine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "milrinone", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "milrinone may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Quinine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "rasagiline", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "arsenic trioxide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "primidone", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "ramipril", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "captopril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "sildenafil may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "doxazosin", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Torasemide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "procarbazine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "halothane", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "halothane may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "latanoprost", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "pargyline", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "pargyline", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "pargyline", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "phentolamine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "pargyline", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "terazosin", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "terazosin", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "terazosin", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "terazosin", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "terazosin", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "terazosin", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Udenafil", "drug2": "alfuzosin", "interaction_type": 60, "interaction_text": "Udenafil may increase the hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "methyclothiazide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of methyclothiazide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Travoprost", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "perphenazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "betaxolol", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "REMIFENTANIL", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of REMIFENTANIL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "losartan", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "furazolidone", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "quinapril", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "polythiazide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "losartan", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "DEXMEDETOMIDINE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Quinine", "drug2": "clonidine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of clonidine.", "severity": 2}
{"drug1": "Quinine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "buprenorphine", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of buprenorphine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "benazepril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "indapamide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Risedronic acid", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Risedronic acid.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "cilazapril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "promethazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "promethazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "rasagiline", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "clonidine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "metolazone", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "losartan", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "losartan", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "selegiline", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "selegiline", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "hydralazine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "moclobemide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "benazepril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "metolazone", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "molsidomine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "reserpine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Methadyl acetate", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Methadyl acetate.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "isoxsuprine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of isoxsuprine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "TAMSULOSIN", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of TAMSULOSIN.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Eplerenone", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Eplerenone.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "thiamylal", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "alfuzosin", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of alfuzosin.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "moclobemide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Arotinolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Spirapril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "selegiline", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "selegiline", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "halothane", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of halothane.", "severity": 2}
{"drug1": "thiopental", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "brimonidine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of brimonidine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "propranolol", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Sapropterin", "drug2": "sildenafil", "interaction_type": 60, "interaction_text": "Sapropterin may increase the hypotensive activities of sildenafil.", "severity": 2}
{"drug1": "Remikiren", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "pargyline", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "selegiline", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "primidone", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "penbutolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "penbutolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "procarbazine", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Quinine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "atenolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "procarbazine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "tolazoline", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Dapagliflozin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Dapagliflozin.", "severity": 2}
{"drug1": "tolazoline", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "selegiline", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "molsidomine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "propoxyphene", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of propoxyphene.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "primidone", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Bretylium", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "xylometazoline may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "procarbazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "losartan", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Pinaverium", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Pinaverium.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "lisinopril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "Travoprost", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "desipramine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "desipramine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "timolol", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "captopril", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "hydromorphone", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of hydromorphone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "clonidine", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "captopril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "quinapril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "losartan", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "losartan", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "losartan", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "isocarboxazid", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Quinine", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "primidone", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Quinine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "isradipine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "captopril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "losartan", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "valsartan", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "doxazosin", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "rasagiline", "drug2": "losartan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "furazolidone", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Torasemide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "fosinopril", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "fosinopril", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "DESFLURANE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "atenolol", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "trimipramine may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "latanoprost", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "ramipril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "tibolone", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "tibolone may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "captopril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "reserpine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "pargyline", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "nadolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "nimodipine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Spirapril may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "labetalol", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "nimodipine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "SUFENTANIL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of SUFENTANIL.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "DESERPIDINE", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "DESERPIDINE may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "thiopental", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "quinapril", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "clonidine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "nitroglycerin", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of nitroglycerin.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "reserpine", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Avanafil", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "Avanafil may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "timolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "Canagliflozin may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "triamterene", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of triamterene.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "minoxidil", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "timolol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Remikiren", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "terazosin", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "felodipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "AMILORIDE", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of AMILORIDE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Pipamperone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Pipamperone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "quinapril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "captopril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "pargyline", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "primidone", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "molsidomine", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Travoprost", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "DEZOCINE", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of DEZOCINE.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "prazosin", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "METYROSINE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "METYROSINE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Travoprost", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Quinine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "benazepril", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Pinaverium may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "benazepril", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "diazoxide", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Arotinolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of Arotinolol.", "severity": 2}
{"drug1": "metolazone", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "primidone", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "thiopental", "drug2": "losartan", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Aliskiren may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "phentolamine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "pargyline", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "pargyline", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "latanoprost", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "pargyline", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "ramipril", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "isradipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "captopril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "felodipine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "nimesulide may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "captopril", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "prazosin", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "timolol", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "SUFENTANIL", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of SUFENTANIL.", "severity": 2}
{"drug1": "benazepril", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "reserpine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "losartan", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "phentolamine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "guanabenz", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "guanabenz", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Azelnidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Azelnidipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Benidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Benidipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Efonidipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Quinine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Pentyl nitrite", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Pentyl nitrite.", "severity": 2}
{"drug1": "Quinine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "valsartan", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "bromocriptine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "valsartan", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "manidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "manidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "alprenolol", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Bretylium", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Bretylium may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "captopril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "secobarbital", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "captopril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "captopril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "furazolidone", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "timolol", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "baclofen", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "baclofen may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "periciazine", "drug2": "HYDROCODONE", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of HYDROCODONE.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "BUPRANOLOL may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "prazosin", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "enalapril", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "methyldopa", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "nadolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "thiopental", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "timolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Conivaptan", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Conivaptan.", "severity": 2}
{"drug1": "Quinine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "clonidine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "primidone", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Bethanidine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Bethanidine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "procarbazine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "phentolamine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Tramadol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of Tramadol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "primidone", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "propranolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "labetalol", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "reserpine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "reserpine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "metolazone", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "apomorphine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "clonidine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "thiamylal", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "thiamylal", "drug2": "timolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "bromocriptine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of bromocriptine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "D-mannitol may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ETHACRYNIC ACID", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "primidone", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "DEZOCINE", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of DEZOCINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Empagliflozin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Empagliflozin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "flunarizine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of flunarizine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "Quinine", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Lacidipine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "Quinine", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "furazolidone", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "promethazine", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "ISOSORBIDE MONONITRATE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "terazosin", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "moclobemide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Remikiren", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "thiopental", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Travoprost", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "fosinopril", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "procarbazine", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "methyldopa", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "tolazoline", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "benazepril", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "procarbazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "periciazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "metolazone", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "alprenolol", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "clonidine", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "pargyline", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "pargyline", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "pargyline", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "ramipril", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "selegiline", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nitroglycerin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "latanoprost", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "amiodarone may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "tolazoline", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "phentolamine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "nifedipine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "irbesartan", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "irbesartan may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "thalidomide", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "thalidomide may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "DIHYDROCODEINE", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "metolazone", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "isoxsuprine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "furazolidone", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "guanabenz", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "ramipril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Remikiren", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "phentolamine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "benazepril", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "hydralazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "timolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "propoxyphene", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of propoxyphene.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "valsartan", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "reserpine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of reserpine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "sildenafil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of sildenafil.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "REMIFENTANIL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of REMIFENTANIL.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "ISOSORBIDE DINITRATE may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "benazepril", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "labetalol", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "selegiline", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Nebivolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Lofexidine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Clofarabine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Clofarabine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "prazosin", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "pargyline", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "rasagiline", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "nicardipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "diazoxide", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "metolazone", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "Silodosin may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "fosinopril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "morphine", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of morphine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "cilnidipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of cilnidipine.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "molsidomine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "trimeprazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "enalapril", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "enalapril may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "hydralazine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "Canagliflozin may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Quinine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "propranolol", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "PERHEXILINE", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of PERHEXILINE.", "severity": 2}
{"drug1": "prazosin", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "quinapril", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "quinapril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "quinapril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "indapamide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "procarbazine", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "primidone", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "metoprolol may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "labetalol", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "reserpine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "reserpine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "minoxidil", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "polythiazide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "nadolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "nadolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "clonidine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "hydralazine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "timolol", "drug2": "hydroflumethiazide", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of hydroflumethiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "amiodarone", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of amiodarone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "minoxidil", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "indapamide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "indapamide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "indapamide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Phenelzine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Phenelzine.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "epoprostenol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "MOXONIDINE", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of MOXONIDINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "amiodarone", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of amiodarone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "losartan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "nicardipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of nicardipine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "labetalol", "drug2": "Pregabalin", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Pregabalin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "methylene blue", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "thiopental", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "thiopental", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "thiopental", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "timolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Treprostinil", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Treprostinil.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "fosinopril", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "losartan", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "Remikiren may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "promethazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "promethazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "felodipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "selegiline", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "trichlormethiazide", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of trichlormethiazide.", "severity": 2}
{"drug1": "captopril", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "amiodarone", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of amiodarone.", "severity": 2}
{"drug1": "thiopental", "drug2": "NITROUS ACID", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of NITROUS ACID.", "severity": 2}
{"drug1": "prazosin", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "procarbazine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "rescinnamine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "acebutolol", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "acebutolol may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "thiopental", "drug2": "amiodarone", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of amiodarone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "irbesartan", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of irbesartan.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "trichlormethiazide may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "thiopental", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "thiopental", "drug2": "nifedipine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of nifedipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "pargyline", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "primidone", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "doxazosin", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "selegiline", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of selegiline.", "severity": 2}
{"drug1": "pargyline", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "diazoxide", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "diazoxide may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Clevidipine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Clevidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "losartan", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "procarbazine", "drug2": "pargyline", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of pargyline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "procarbazine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "labetalol", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "propranolol", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "Levomepromazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "fosinopril", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "Canagliflozin may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "alprenolol", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of alprenolol.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "Riociguat may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "papaverine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of papaverine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "thiopental", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Empagliflozin", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Empagliflozin.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "felodipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "eperisone", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of eperisone.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "valsartan", "drug2": "cyclothiazide", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of cyclothiazide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "clonidine", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "clonidine may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "hydrochlorothiazide", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "periciazine", "drug2": "Methadyl acetate", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of Methadyl acetate.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "cilostazol may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "prazosin", "interaction_type": 60, "interaction_text": "Tadalafil may increase the hypotensive activities of prazosin.", "severity": 2}
{"drug1": "fenoldopam", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "fenoldopam may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "diltiazem", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of diltiazem.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "pargyline", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "metolazone may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "losartan", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "timolol", "interaction_type": 60, "interaction_text": "phenobarbital may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "trandolapril", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "celiprolol may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Thioproperazine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "eperisone", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "eperisone may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "molsidomine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Metipranolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Bortezomib", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of Bortezomib.", "severity": 2}
{"drug1": "rasagiline", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "methyldopa", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of methyldopa.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "chlorothiazide", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of chlorothiazide.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Telmisartan", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Telmisartan.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "betaxolol", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ILOPROST", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of ILOPROST.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "thioridazine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "selegiline", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "selegiline", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "atenolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "Terlipressin", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "Terlipressin may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "mecamylamine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "benazepril", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Bretylium", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Bretylium.", "severity": 2}
{"drug1": "moclobemide", "drug2": "captopril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "doxazosin", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "doxazosin", "drug2": "gabapentin", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of gabapentin.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "metolazone", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of metolazone.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "phenoxybenzamine may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "timolol", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "bepridil", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "bepridil", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Telmisartan may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "bumetanide may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Amrinone", "interaction_type": 60, "interaction_text": "labetalol may increase the hypotensive activities of Amrinone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "phentolamine", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "phentolamine may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "pargyline", "drug2": "NICORANDIL", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of NICORANDIL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "alfuzosin may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "apomorphine", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of apomorphine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "TAMSULOSIN may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "MOEXIPRIL may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "nitrendipine", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of nitrendipine.", "severity": 2}
{"drug1": "benazepril", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Olmesartan may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "valsartan", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "moclobemide", "drug2": "chlorthalidone", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of chlorthalidone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Carbetocin", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Carbetocin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "sotalol", "interaction_type": 60, "interaction_text": "Aceprometazine may increase the hypotensive activities of sotalol.", "severity": 2}
{"drug1": "gabapentin", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "gabapentin may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "amifostine", "interaction_type": 60, "interaction_text": "nitrendipine may increase the hypotensive activities of amifostine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "furazolidone", "drug2": "nimodipine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of nimodipine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "rasagiline", "interaction_type": 60, "interaction_text": "secobarbital may increase the hypotensive activities of rasagiline.", "severity": 2}
{"drug1": "ibudilast", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "ibudilast may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "amobarbital", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "hydralazine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "hydralazine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "barnidipine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of barnidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tretinoin", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of tretinoin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "isoflurane", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of isoflurane.", "severity": 2}
{"drug1": "methylene blue", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Lercanidipine", "interaction_type": 60, "interaction_text": "Bethanidine may increase the hypotensive activities of Lercanidipine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "periciazine", "drug2": "DIPHENOXYLATE", "interaction_type": 60, "interaction_text": "periciazine may increase the hypotensive activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amphotericin b", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of amphotericin b.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "Remikiren", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Remikiren.", "severity": 2}
{"drug1": "Quinine", "drug2": "Torasemide", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of Torasemide.", "severity": 2}
{"drug1": "benazepril", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "apraclonidine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of apraclonidine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "nilvadipine may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Bevantolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of Bevantolol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "practolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of practolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "felodipine", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of felodipine.", "severity": 2}
{"drug1": "levodopa", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "levodopa may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "cilazapril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "Mephobarbital may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "metoprolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of metoprolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "mesoridazine may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "terazosin", "drug2": "cinnarizine", "interaction_type": 60, "interaction_text": "terazosin may increase the hypotensive activities of cinnarizine.", "severity": 2}
{"drug1": "losartan", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "losartan may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Aliskiren", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Aliskiren.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ramipril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of ramipril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "valsartan", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of valsartan.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "furazolidone", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "oxprenolol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "primidone", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Olmesartan", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of Olmesartan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "isradipine", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of isradipine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "propranolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of propranolol.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "VERAPAMIL", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of VERAPAMIL.", "severity": 2}
{"drug1": "rasagiline", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "captopril", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of captopril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "acebutolol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of acebutolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "METHOHEXITAL may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Debrisoquine", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of Debrisoquine.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Candesartan cilexetil may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "tizanidine may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "tolazoline", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "tolazoline", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "timolol", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "timolol may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "chlorothiazide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "D-mannitol", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of D-mannitol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "Bosentan may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pargyline", "drug2": "Travoprost", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of Travoprost.", "severity": 2}
{"drug1": "isradipine", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "isradipine may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "bepridil", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "carvedilol may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "ethanol", "drug2": "Avanafil", "interaction_type": 60, "interaction_text": "ethanol may increase the hypotensive activities of Avanafil.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "morphine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of morphine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "bupivacaine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of bupivacaine.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "Ropivacaine", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of Ropivacaine.", "severity": 2}
{"drug1": "methyldopa", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "propranolol", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "propranolol may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "procarbazine", "drug2": "fenoldopam", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of fenoldopam.", "severity": 2}
{"drug1": "Nitroprusside", "drug2": "METYROSINE", "interaction_type": 60, "interaction_text": "Nitroprusside may increase the hypotensive activities of METYROSINE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "celiprolol", "interaction_type": 60, "interaction_text": "tranylcypromine may increase the hypotensive activities of celiprolol.", "severity": 2}
{"drug1": "procarbazine", "drug2": "indapamide", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of indapamide.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "doxazosin", "interaction_type": 60, "interaction_text": "Vardenafil may increase the hypotensive activities of doxazosin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "thiopental", "drug2": "spironolactone", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of spironolactone.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "tibolone", "interaction_type": 60, "interaction_text": "Pentolinium may increase the hypotensive activities of tibolone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "diltiazem may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "perphenazine", "drug2": "CARTEOLOL", "interaction_type": 60, "interaction_text": "perphenazine may increase the hypotensive activities of CARTEOLOL.", "severity": 2}
{"drug1": "latanoprost", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "latanoprost may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "nilvadipine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of nilvadipine.", "severity": 2}
{"drug1": "pargyline", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Bimatoprost", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "Bimatoprost may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "timolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Sitaxsentan", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Sitaxsentan.", "severity": 2}
{"drug1": "Quinine", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "Quinine may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "minoxidil may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "pentobarbital may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "terazosin", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of terazosin.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "NICORANDIL", "drug2": "arsenic trioxide", "interaction_type": 60, "interaction_text": "NICORANDIL may increase the hypotensive activities of arsenic trioxide.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "timolol", "interaction_type": 60, "interaction_text": "trifluoperazine may increase the hypotensive activities of timolol.", "severity": 2}
{"drug1": "cyclothiazide", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "cyclothiazide may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "Clevidipine may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "molsidomine", "drug2": "PERINDOPRIL", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "manidipine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of manidipine.", "severity": 2}
{"drug1": "reserpine", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Candesartan cilexetil", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "molsidomine", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Lofexidine", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Lofexidine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Efonidipine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Efonidipine.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "latanoprost", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of latanoprost.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "mecamylamine", "interaction_type": 60, "interaction_text": "Phenelzine may increase the hypotensive activities of mecamylamine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Lacidipine", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Lacidipine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "prazosin", "drug2": "tolazoline", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of tolazoline.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "BOPINDOLOL", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of BOPINDOLOL.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "atenolol", "interaction_type": 60, "interaction_text": "TRIMETHAPHAN may increase the hypotensive activities of atenolol.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Unoprostone", "interaction_type": 60, "interaction_text": "MOXONIDINE may increase the hypotensive activities of Unoprostone.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "losartan", "interaction_type": 60, "interaction_text": "Debrisoquine may increase the hypotensive activities of losartan.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "trandolapril may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Travoprost", "drug2": "labetalol", "interaction_type": 60, "interaction_text": "Travoprost may increase the hypotensive activities of labetalol.", "severity": 2}
{"drug1": "bepridil", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "bepridil may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Sacubitril", "interaction_type": 60, "interaction_text": "thiamylal may increase the hypotensive activities of Sacubitril.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "nimodipine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "LEVOSIMENDAN", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of LEVOSIMENDAN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nitric oxide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of nitric oxide.", "severity": 2}
{"drug1": "GUANADREL", "drug2": "oxprenolol", "interaction_type": 60, "interaction_text": "GUANADREL may increase the hypotensive activities of oxprenolol.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "GUANFACINE may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "furazolidone may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "benazepril", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "benazepril may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Toloxatone may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "penbutolol", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of penbutolol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tizanidine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of tizanidine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "furosemide", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of furosemide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "phentolamine", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of phentolamine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "MOEXIPRIL", "interaction_type": 60, "interaction_text": "Aripiprazole may increase the hypotensive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "valsartan", "drug2": "GUANADREL", "interaction_type": 60, "interaction_text": "valsartan may increase the hypotensive activities of GUANADREL.", "severity": 2}
{"drug1": "guanabenz", "drug2": "rescinnamine", "interaction_type": 60, "interaction_text": "guanabenz may increase the hypotensive activities of rescinnamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Lercanidipine may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "risperidone", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of risperidone.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "xylometazoline", "interaction_type": 60, "interaction_text": "GUANETHIDINE may increase the hypotensive activities of xylometazoline.", "severity": 2}
{"drug1": "thiopental", "drug2": "cilazapril", "interaction_type": 60, "interaction_text": "thiopental may increase the hypotensive activities of cilazapril.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "nadolol", "interaction_type": 60, "interaction_text": "FLUPHENAZINE may increase the hypotensive activities of nadolol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "buprenorphine", "interaction_type": 60, "interaction_text": "MORICIZINE may increase the hypotensive activities of buprenorphine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Enalaprilat may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "phenoxybenzamine", "interaction_type": 60, "interaction_text": "alprenolol may increase the hypotensive activities of phenoxybenzamine.", "severity": 2}
{"drug1": "molsidomine", "drug2": "diazoxide", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of diazoxide.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "trandolapril", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of trandolapril.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "procarbazine may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "hydromorphone", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of hydromorphone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Nitroprusside", "interaction_type": 60, "interaction_text": "methylene blue may increase the hypotensive activities of Nitroprusside.", "severity": 2}
{"drug1": "Torasemide", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "Torasemide may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "molsidomine", "drug2": "TRIMETHAPHAN", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of TRIMETHAPHAN.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "Pirlindole may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "CARTEOLOL may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "moclobemide", "drug2": "fosinopril", "interaction_type": 60, "interaction_text": "moclobemide may increase the hypotensive activities of fosinopril.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "quinapril", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of quinapril.", "severity": 2}
{"drug1": "rasagiline", "drug2": "lisinopril", "interaction_type": 60, "interaction_text": "rasagiline may increase the hypotensive activities of lisinopril.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "epoprostenol", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of epoprostenol.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "GUANFACINE", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of GUANFACINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Bosentan", "interaction_type": 60, "interaction_text": "isocarboxazid may increase the hypotensive activities of Bosentan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "carvedilol", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of carvedilol.", "severity": 2}
{"drug1": "ramipril", "drug2": "GUANETHIDINE", "interaction_type": 60, "interaction_text": "ramipril may increase the hypotensive activities of GUANETHIDINE.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Macitentan", "interaction_type": 60, "interaction_text": "hydrochlorothiazide may increase the hypotensive activities of Macitentan.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "hydralazine", "interaction_type": 60, "interaction_text": "pentoxifylline may increase the hypotensive activities of hydralazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "selegiline may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Terlipressin", "interaction_type": 60, "interaction_text": "fosinopril may increase the hypotensive activities of Terlipressin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ESMOLOL", "interaction_type": 60, "interaction_text": "Hexobarbital may increase the hypotensive activities of ESMOLOL.", "severity": 2}
{"drug1": "Unoprostone", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "Unoprostone may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "enalapril", "interaction_type": 60, "interaction_text": "AMPHETAMINE may increase the hypotensive activities of enalapril.", "severity": 2}
{"drug1": "primidone", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "primidone may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Pentolinium", "interaction_type": 60, "interaction_text": "BISOPROLOL may increase the hypotensive activities of Pentolinium.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "BISOPROLOL", "interaction_type": 60, "interaction_text": "Treprostinil may increase the hypotensive activities of BISOPROLOL.", "severity": 2}
{"drug1": "tolazoline", "drug2": "Eprosartan", "interaction_type": 60, "interaction_text": "tolazoline may increase the hypotensive activities of Eprosartan.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "betaxolol", "interaction_type": 60, "interaction_text": "triflupromazine may increase the hypotensive activities of betaxolol.", "severity": 2}
{"drug1": "molsidomine", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "prazosin", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "prazosin may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "reserpine", "drug2": "Spirapril", "interaction_type": 60, "interaction_text": "reserpine may increase the hypotensive activities of Spirapril.", "severity": 2}
{"drug1": "ILOPROST", "drug2": "minoxidil", "interaction_type": 60, "interaction_text": "ILOPROST may increase the hypotensive activities of minoxidil.", "severity": 2}
{"drug1": "captopril", "drug2": "polythiazide", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of polythiazide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "guanabenz", "interaction_type": 60, "interaction_text": "chlorthalidone may increase the hypotensive activities of guanabenz.", "severity": 2}
{"drug1": "molsidomine", "drug2": "nisoldipine", "interaction_type": 60, "interaction_text": "molsidomine may increase the hypotensive activities of nisoldipine.", "severity": 2}
{"drug1": "captopril", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "captopril may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "LEVOBUNOLOL", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of LEVOBUNOLOL.", "severity": 2}
{"drug1": "doxazosin", "drug2": "nimesulide", "interaction_type": 60, "interaction_text": "doxazosin may increase the hypotensive activities of nimesulide.", "severity": 2}
{"drug1": "betaxolol", "drug2": "DESERPIDINE", "interaction_type": 60, "interaction_text": "betaxolol may increase the hypotensive activities of DESERPIDINE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Metipranolol", "interaction_type": 60, "interaction_text": "prochlorperazine may increase the hypotensive activities of Metipranolol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Nebivolol", "interaction_type": 60, "interaction_text": "amobarbital may increase the hypotensive activities of Nebivolol.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Enalaprilat", "interaction_type": 60, "interaction_text": "methyldopa may increase the hypotensive activities of Enalaprilat.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "dorzolamide", "interaction_type": 60, "interaction_text": "PERINDOPRIL may increase the hypotensive activities of dorzolamide.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Riociguat", "interaction_type": 60, "interaction_text": "ISOSORBIDE MONONITRATE may increase the hypotensive activities of Riociguat.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "bepridil", "interaction_type": 60, "interaction_text": "Eprosartan may increase the hypotensive activities of bepridil.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "BUPRANOLOL", "interaction_type": 60, "interaction_text": "hydroflumethiazide may increase the hypotensive activities of BUPRANOLOL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Ambrisentan", "interaction_type": 60, "interaction_text": "dorzolamide may increase the hypotensive activities of Ambrisentan.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Bimatoprost", "interaction_type": 60, "interaction_text": "nisoldipine may increase the hypotensive activities of Bimatoprost.", "severity": 2}
{"drug1": "pargyline", "drug2": "benazepril", "interaction_type": 60, "interaction_text": "pargyline may increase the hypotensive activities of benazepril.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "thioridazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of thioridazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Ziprasidone", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Ziprasidone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Levomepromazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Levomepromazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "haloperidol", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of haloperidol.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "promazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of promazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Levomepromazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Levomepromazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "promazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of promazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Levomepromazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Levomepromazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "thioridazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of thioridazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "clozapine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of clozapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "clozapine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of clozapine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "clozapine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of clozapine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Ziprasidone", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Ziprasidone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "haloperidol", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of haloperidol.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "promazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of promazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "thioridazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of thioridazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "tiapride", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of tiapride.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "haloperidol", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of haloperidol.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "thioridazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of thioridazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "risperidone", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of risperidone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "loxapine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of loxapine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "thioridazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of thioridazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "clozapine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of clozapine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ACETOPHENAZINE", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Pipamperone", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Pipamperone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Remoxipride", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Remoxipride.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "olanzapine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of olanzapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Levomepromazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Levomepromazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "zotepine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of zotepine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "MELPERONE", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of MELPERONE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "periciazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of periciazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Ziprasidone", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Ziprasidone.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "haloperidol", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of haloperidol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "pimozide", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of pimozide.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "FLUPHENAZINE", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "trifluoperazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of trifluoperazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "sulpiride", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of sulpiride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Ziprasidone", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Ziprasidone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Perospirone", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Perospirone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "clozapine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of clozapine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Fluspirilene", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Fluspirilene.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "reserpine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of reserpine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Aripiprazole", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Aripiprazole.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "chlorprothixene", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of chlorprothixene.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Asenapine", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Asenapine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "droperidol", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of droperidol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Aceprometazine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Aceprometazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "MOLINDONE", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of MOLINDONE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Paliperidone", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of Paliperidone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "mesoridazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of mesoridazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "prochlorperazine", "interaction_type": 61, "interaction_text": "dextroamphetamine may decrease the stimulatory activities of prochlorperazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Cyamemazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of Cyamemazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "perphenazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of perphenazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "promazine", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of promazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Cariprazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Cariprazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ondansetron", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of ondansetron.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Fencamfamin", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of Fencamfamin.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Levomepromazine", "interaction_type": 61, "interaction_text": "Lisdexamfetamine may decrease the stimulatory activities of Levomepromazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Lurasidone", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Lurasidone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "promazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of promazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "benzphetamine may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "SERTINDOLE", "interaction_type": 61, "interaction_text": "hydroxyamphetamine may decrease the stimulatory activities of SERTINDOLE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "haloperidol", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of haloperidol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "quetiapine", "interaction_type": 61, "interaction_text": "AMPHETAMINE may decrease the stimulatory activities of quetiapine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Flupentixol", "interaction_type": 61, "interaction_text": "METHAMPHETAMINE may decrease the stimulatory activities of Flupentixol.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "lithium ion", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of lithium ion.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Iloperidone", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of Iloperidone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "thiothixene", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of thiothixene.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Thioproperazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Thioproperazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Pipotiazine", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Pipotiazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Zuclopenthixol", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of Zuclopenthixol.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "amisulpride", "interaction_type": 61, "interaction_text": "MEPHENTERMINE may decrease the stimulatory activities of amisulpride.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "Amfepramone may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "triflupromazine", "interaction_type": 61, "interaction_text": "PSEUDOEPHEDRINE may decrease the stimulatory activities of triflupromazine.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "bromocriptine", "interaction_type": 62, "interaction_text": "The bioavailability of bromocriptine can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "LISURIDE", "interaction_type": 62, "interaction_text": "The bioavailability of LISURIDE can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "fexofenadine", "interaction_type": 62, "interaction_text": "The bioavailability of fexofenadine can be increased when combined with VERAPAMIL.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "methylergonovine", "interaction_type": 62, "interaction_text": "The bioavailability of methylergonovine can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "methysergide", "interaction_type": 62, "interaction_text": "The bioavailability of methysergide can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "pergolide", "interaction_type": 62, "interaction_text": "The bioavailability of pergolide can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "ERGOTAMINE", "interaction_type": 62, "interaction_text": "The bioavailability of ERGOTAMINE can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "nicergoline", "interaction_type": 62, "interaction_text": "The bioavailability of nicergoline can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "cabergoline", "interaction_type": 62, "interaction_text": "The bioavailability of cabergoline can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "nitroglycerin", "drug2": "dihydroergotamine", "interaction_type": 62, "interaction_text": "The bioavailability of dihydroergotamine can be increased when combined with nitroglycerin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "Spirapril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of Spirapril.", "severity": 2}
{"drug1": "azathioprine", "drug2": "fosinopril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of fosinopril.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "azathioprine", "interaction_type": 63, "interaction_text": "6-Mercaptopurine may increase the myelosuppressive activities of azathioprine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "cisplatin", "interaction_type": 63, "interaction_text": "CABAZITAXEL may increase the myelosuppressive activities of cisplatin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "oxaliplatin", "interaction_type": 63, "interaction_text": "docetaxel may increase the myelosuppressive activities of oxaliplatin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "quinapril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of quinapril.", "severity": 2}
{"drug1": "azathioprine", "drug2": "trandolapril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of trandolapril.", "severity": 2}
{"drug1": "azathioprine", "drug2": "rescinnamine", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of rescinnamine.", "severity": 2}
{"drug1": "azathioprine", "drug2": "MOEXIPRIL", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of MOEXIPRIL.", "severity": 2}
{"drug1": "docetaxel", "drug2": "carboplatin", "interaction_type": 63, "interaction_text": "docetaxel may increase the myelosuppressive activities of carboplatin.", "severity": 2}
{"drug1": "carmustine", "drug2": "cimetidine", "interaction_type": 63, "interaction_text": "carmustine may increase the myelosuppressive activities of cimetidine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Nedaplatin", "interaction_type": 63, "interaction_text": "docetaxel may increase the myelosuppressive activities of Nedaplatin.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "trimethoprim", "interaction_type": 63, "interaction_text": "6-Mercaptopurine may increase the myelosuppressive activities of trimethoprim.", "severity": 2}
{"drug1": "azathioprine", "drug2": "cilazapril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of cilazapril.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "oxaliplatin", "interaction_type": 63, "interaction_text": "CABAZITAXEL may increase the myelosuppressive activities of oxaliplatin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "enalapril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of enalapril.", "severity": 2}
{"drug1": "clozapine", "drug2": "carbamazepine", "interaction_type": 63, "interaction_text": "clozapine may increase the myelosuppressive activities of carbamazepine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "clarithromycin", "interaction_type": 63, "interaction_text": "zidovudine may increase the myelosuppressive activities of clarithromycin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "cisplatin", "interaction_type": 63, "interaction_text": "docetaxel may increase the myelosuppressive activities of cisplatin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "trimethoprim", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of trimethoprim.", "severity": 2}
{"drug1": "azathioprine", "drug2": "sulfamethoxazole", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of sulfamethoxazole.", "severity": 2}
{"drug1": "azathioprine", "drug2": "lisinopril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of lisinopril.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "carboplatin", "interaction_type": 63, "interaction_text": "CABAZITAXEL may increase the myelosuppressive activities of carboplatin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "captopril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of captopril.", "severity": 2}
{"drug1": "azathioprine", "drug2": "Enalaprilat", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of Enalaprilat.", "severity": 2}
{"drug1": "azathioprine", "drug2": "benazepril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of benazepril.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "sulfamethoxazole", "interaction_type": 63, "interaction_text": "6-Mercaptopurine may increase the myelosuppressive activities of sulfamethoxazole.", "severity": 2}
{"drug1": "azathioprine", "drug2": "PERINDOPRIL", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of PERINDOPRIL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Nedaplatin", "interaction_type": 63, "interaction_text": "CABAZITAXEL may increase the myelosuppressive activities of Nedaplatin.", "severity": 2}
{"drug1": "azathioprine", "drug2": "ramipril", "interaction_type": 63, "interaction_text": "azathioprine may increase the myelosuppressive activities of ramipril.", "severity": 2}
{"drug1": "sertraline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "zolmitriptan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "mirtazapine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "Pirlindole may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Escitalopram", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Escitalopram.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "moclobemide", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of moclobemide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "mirtazapine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Toloxatone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "trazodone", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "ERGOTAMINE may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "linezolid", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "linezolid may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "furazolidone", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "furazolidone may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "rizatriptan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "furazolidone", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "furazolidone may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "imipramine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "hydromorphone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of hydromorphone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Frovatriptan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Safinamide", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Safinamide may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "buspirone", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "buspirone may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "selegiline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of selegiline.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "Tianeptine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "AMPHETAMINE may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Frovatriptan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Lorcaserin may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "ondansetron", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "ondansetron may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "doxepin", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "nefazodone", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "oxycodone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of oxycodone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "bromocriptine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "trimipramine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "SUFENTANIL", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "SUFENTANIL", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of SUFENTANIL.", "severity": 2}
{"drug1": "imipramine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Ketobemidone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Ketobemidone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "zolmitriptan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "sertraline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of sertraline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "ERGOTAMINE may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "imipramine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of imipramine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Milnacipran", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of Milnacipran.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "chlorpheniramine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "rizatriptan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Milnacipran", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Milnacipran.", "severity": 2}
{"drug1": "trazodone", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "citalopram", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "sumatriptan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Tapentadol may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "doxepin", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Frovatriptan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "doxepin", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "doxepin", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "citalopram", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of citalopram.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "selegiline", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "sertraline", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "desipramine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Lorcaserin may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "paroxetine", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "nefazodone", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Eletriptan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "levodopa", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "levodopa may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "nefazodone", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Eletriptan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "fluvoxamine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of fluvoxamine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Tedizolid phosphate may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "paroxetine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of paroxetine.", "severity": 2}
{"drug1": "sertraline", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "cabergoline", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "cabergoline may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "protriptyline", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "nefazodone", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of nefazodone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "SUFENTANIL", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of SUFENTANIL.", "severity": 2}
{"drug1": "desipramine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "methadone", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "methadone may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "AMPHETAMINE", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Almotriptan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "olanzapine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "doxepin", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Tapentadol may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "hydromorphone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of hydromorphone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "bromocriptine may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "zolmitriptan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Lorcaserin may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "cocaine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "cocaine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "tranylcypromine", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of tranylcypromine.", "severity": 2}
{"drug1": "doxepin", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "rizatriptan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Lorcaserin may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "mirtazapine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "buprenorphine", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of buprenorphine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "rasagiline", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of rasagiline.", "severity": 2}
{"drug1": "sertraline", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "isocarboxazid", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of isocarboxazid.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "ERGOTAMINE may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "rasagiline", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "paroxetine", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "imipramine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "oxymorphone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of oxymorphone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "Toloxatone may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "venlafaxine", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of venlafaxine.", "severity": 2}
{"drug1": "citalopram", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "linezolid", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "linezolid may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "trazodone", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "HYDROCODONE", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of HYDROCODONE.", "severity": 2}
{"drug1": "desipramine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "trazodone", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "methylene blue", "drug2": "desipramine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of desipramine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "HYDROCODONE", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of HYDROCODONE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "bromocriptine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "furazolidone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "furazolidone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "citalopram", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "cabergoline may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Phenelzine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of Phenelzine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Milnacipran", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of Milnacipran.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Dothiepin", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of Dothiepin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Almotriptan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "nefazodone", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "DIHYDROCODEINE", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "sertraline", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of sertraline.", "severity": 2}
{"drug1": "desipramine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "linezolid", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "linezolid may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "rasagiline", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "pentazocine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "pentazocine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "ERGOTAMINE may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "nefazodone", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "selegiline", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "buspirone", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "buspirone may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "sertraline", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "AMPHETAMINE", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "promethazine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "promethazine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Tedizolid phosphate may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "codeine", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of codeine.", "severity": 2}
{"drug1": "selegiline", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "imipramine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "imipramine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "sumatriptan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "maprotiline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "SUFENTANIL", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "HYDROCODONE", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of HYDROCODONE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "sumatriptan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Eletriptan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "meperidine", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "meperidine may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "trazodone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "nefazodone", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "oxymorphone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of oxymorphone.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "citalopram", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "buprenorphine", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of buprenorphine.", "severity": 2}
{"drug1": "imipramine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "cabergoline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "protriptyline", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "dihydroergotamine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "olanzapine", "drug2": "sertraline", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of sertraline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Ketobemidone", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of Ketobemidone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Tedizolid phosphate may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "procarbazine", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "meperidine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Frovatriptan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Eletriptan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "nefazodone", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "SUFENTANIL", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of SUFENTANIL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "rasagiline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of rasagiline.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "dihydroergotamine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "doxepin", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "citalopram", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "procarbazine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of procarbazine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "methadone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "methadone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "clomipramine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "desipramine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "bromocriptine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "rizatriptan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "sertraline", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "protriptyline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of protriptyline.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "paroxetine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "buspirone", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "buspirone may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "protriptyline", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "naratriptan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "naratriptan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "selegiline", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "sertraline", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "nefazodone", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "methadone", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "methadone may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "morphine", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of morphine.", "severity": 2}
{"drug1": "meperidine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "meperidine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "trazodone", "drug2": "AMPHETAMINE", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "pargyline", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "pargyline may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "SUFENTANIL", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of SUFENTANIL.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "zolmitriptan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "meperidine", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "meperidine may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Tedizolid phosphate may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "duloxetine", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "lithium ion may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "methylene blue", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of methylene blue.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "isocarboxazid", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of isocarboxazid.", "severity": 2}
{"drug1": "sertraline", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "desipramine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "buspirone", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "buspirone may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "fluvoxamine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of fluvoxamine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "duloxetine", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Levomilnacipran", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "citalopram", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "ERGOTAMINE may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "Toloxatone may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Phenelzine", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of Phenelzine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "meperidine", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "meperidine may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "promethazine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "promethazine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "lithium ion may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "buspirone", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "buspirone may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Almotriptan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "codeine", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of codeine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "nefazodone", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "naratriptan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "naratriptan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "clomipramine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "methylene blue", "drug2": "isocarboxazid", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of isocarboxazid.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "citalopram", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "clomipramine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "desipramine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "paroxetine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "maprotiline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of maprotiline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "naratriptan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "meperidine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "meperidine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "amoxapine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of amoxapine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nortriptyline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of nortriptyline.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "mirtazapine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "naratriptan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "naratriptan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "tranylcypromine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of tranylcypromine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "desipramine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "trazodone", "drug2": "venlafaxine", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of venlafaxine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "meperidine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "meperidine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "amoxapine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "buspirone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "buspirone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "paroxetine", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "paroxetine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "oxycodone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of oxycodone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "trimipramine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of trimipramine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "promethazine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Ethylmorphine", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Ethylmorphine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "sumatriptan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Eletriptan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Tedizolid phosphate may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Lorcaserin may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "rasagiline", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "cyclobenzaprine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "linezolid", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "linezolid may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "mirtazapine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "procarbazine", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "naratriptan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "naratriptan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Almotriptan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "sumatriptan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "Pirlindole may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "venlafaxine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of venlafaxine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "sertraline", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "zolmitriptan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "olanzapine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "citalopram", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "duloxetine", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "sertraline", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "mirtazapine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "Tramadol", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Tramadol may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "morphine", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of morphine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Levomilnacipran", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of Levomilnacipran.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Frovatriptan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Almotriptan may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "Tianeptine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "citalopram", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "rizatriptan may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "citalopram", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Tramadol may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "selegiline", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "oxymorphone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of oxymorphone.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "selegiline", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "levorphanol", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "levorphanol may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Phenelzine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Phenelzine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "paroxetine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of paroxetine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "amitriptyline may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "selegiline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "ERGOTAMINE may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Escitalopram", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of Escitalopram.", "severity": 2}
{"drug1": "methylene blue", "drug2": "moclobemide", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of moclobemide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "cabergoline may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Ethylmorphine", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Ethylmorphine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Lorcaserin may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "paroxetine", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "methylene blue", "drug2": "mirtazapine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of mirtazapine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "morphine", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of morphine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "fluoxetine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of fluoxetine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "lithium ion", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of lithium ion.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "rizatriptan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Levomilnacipran", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of Levomilnacipran.", "severity": 2}
{"drug1": "duloxetine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Ketobemidone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Ketobemidone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "citalopram", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "citalopram", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "maprotiline", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "maprotiline may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "buspirone", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "buspirone may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "procarbazine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of procarbazine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Frovatriptan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Frovatriptan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Almotriptan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "paroxetine", "drug2": "propoxyphene", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of propoxyphene.", "severity": 2}
{"drug1": "methylene blue", "drug2": "trazodone", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of trazodone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "DIHYDROCODEINE", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "trazodone", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "oxycodone", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of oxycodone.", "severity": 2}
{"drug1": "citalopram", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "selegiline", "drug2": "OXCARBAZEPINE", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of OXCARBAZEPINE.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "clomipramine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "bupropion", "interaction_type": 64, "interaction_text": "Lorcaserin may increase the serotonergic activities of bupropion.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "sertraline", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "citalopram", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "Phenelzine", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "Phenelzine may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "imipramine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "tranylcypromine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of tranylcypromine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "linezolid", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "linezolid may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "nefazodone", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "trazodone", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "bromocriptine may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Eletriptan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "Almotriptan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "clomipramine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "nortriptyline may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "sertraline", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "imipramine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "imipramine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "VORTIOXETINE may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "cabergoline may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "maprotiline may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "trimipramine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "clomipramine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "codeine", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of codeine.", "severity": 2}
{"drug1": "risperidone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "risperidone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "Vilazodone may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "sumatriptan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "procarbazine", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "doxepin", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "bromocriptine may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "linezolid", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "linezolid may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "sumatriptan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylene blue", "drug2": "citalopram", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of citalopram.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "zolmitriptan may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "SUFENTANIL", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of SUFENTANIL.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "DIHYDROCODEINE", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of DIHYDROCODEINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "dihydroergotamine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "rasagiline", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "desipramine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "desipramine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "venlafaxine", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of venlafaxine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Eletriptan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "duloxetine", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "paroxetine", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "AMPHETAMINE may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "lithium ion may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "duloxetine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "amitriptyline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of amitriptyline.", "severity": 2}
{"drug1": "citalopram", "drug2": "Methadyl acetate", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of Methadyl acetate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "nefazodone", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "procarbazine", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "trazodone", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "nefazodone may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "isocarboxazid", "drug2": "cyclobenzaprine", "interaction_type": 64, "interaction_text": "isocarboxazid may increase the serotonergic activities of cyclobenzaprine.", "severity": 2}
{"drug1": "selegiline", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "selegiline may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "moclobemide", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "moclobemide may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "methadone", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "methadone may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "pargyline", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "pargyline may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "maprotiline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "Normethadone", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of Normethadone.", "severity": 2}
{"drug1": "naratriptan", "drug2": "Tedizolid phosphate", "interaction_type": 64, "interaction_text": "naratriptan may increase the serotonergic activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nefazodone", "interaction_type": 64, "interaction_text": "olanzapine may increase the serotonergic activities of nefazodone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "cabergoline may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Ketobemidone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of Ketobemidone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "PHOLCODINE", "interaction_type": 64, "interaction_text": "tranylcypromine may increase the serotonergic activities of PHOLCODINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "lithium ion may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Ethylmorphine", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of Ethylmorphine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "granisetron", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "granisetron may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "sertraline", "drug2": "DEZOCINE", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of DEZOCINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "clomipramine may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "ondansetron", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of ondansetron.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ALFENTANIL", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of ALFENTANIL.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Escitalopram may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "oxycodone", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "oxycodone may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "citalopram", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "Pirlindole may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "procarbazine", "drug2": "granisetron", "interaction_type": 64, "interaction_text": "procarbazine may increase the serotonergic activities of granisetron.", "severity": 2}
{"drug1": "trimipramine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "linezolid", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "linezolid may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "sertraline may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "doxepin", "drug2": "linezolid", "interaction_type": 64, "interaction_text": "doxepin may increase the serotonergic activities of linezolid.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Toloxatone", "interaction_type": 64, "interaction_text": "protriptyline may increase the serotonergic activities of Toloxatone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "nalbuphine", "interaction_type": 64, "interaction_text": "fluoxetine may increase the serotonergic activities of nalbuphine.", "severity": 2}
{"drug1": "bupropion", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "bupropion may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "procarbazine", "interaction_type": 64, "interaction_text": "Dothiepin may increase the serotonergic activities of procarbazine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "levorphanol", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of levorphanol.", "severity": 2}
{"drug1": "citalopram", "drug2": "dolasetron", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of dolasetron.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "citalopram", "drug2": "butorphanol", "interaction_type": 64, "interaction_text": "citalopram may increase the serotonergic activities of butorphanol.", "severity": 2}
{"drug1": "rasagiline", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "rasagiline may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "buprenorphine", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of buprenorphine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "fluoxetine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of fluoxetine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "trimipramine may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "duloxetine", "interaction_type": 64, "interaction_text": "dextromethorphan may increase the serotonergic activities of duloxetine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "nefazodone", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of nefazodone.", "severity": 2}
{"drug1": "trazodone", "drug2": "furazolidone", "interaction_type": 64, "interaction_text": "trazodone may increase the serotonergic activities of furazolidone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "metoclopramide may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "naratriptan", "drug2": "tropisetron", "interaction_type": 64, "interaction_text": "naratriptan may increase the serotonergic activities of tropisetron.", "severity": 2}
{"drug1": "methylene blue", "drug2": "doxepin", "interaction_type": 64, "interaction_text": "methylene blue may increase the serotonergic activities of doxepin.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "L-tryptophan", "interaction_type": 64, "interaction_text": "zolmitriptan may increase the serotonergic activities of L-tryptophan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "HEROIN", "interaction_type": 64, "interaction_text": "Levomilnacipran may increase the serotonergic activities of HEROIN.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "REMIFENTANIL", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of REMIFENTANIL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "pargyline", "interaction_type": 64, "interaction_text": "amoxapine may increase the serotonergic activities of pargyline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "pentazocine", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of pentazocine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "fluvoxamine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "hydromorphone", "interaction_type": 64, "interaction_text": "Milnacipran may increase the serotonergic activities of hydromorphone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Pirlindole", "interaction_type": 64, "interaction_text": "venlafaxine may increase the serotonergic activities of Pirlindole.", "severity": 2}
{"drug1": "paroxetine", "drug2": "DIPHENOXYLATE", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of DIPHENOXYLATE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Palonosetron", "interaction_type": 64, "interaction_text": "rizatriptan may increase the serotonergic activities of Palonosetron.", "severity": 2}
{"drug1": "paroxetine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "paroxetine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "buspirone", "interaction_type": 64, "interaction_text": "duloxetine may increase the serotonergic activities of buspirone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "Normethadone may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "oxymorphone may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "lithium ion", "drug2": "SODIUM BICARBONATE", "interaction_type": 65, "interaction_text": "lithium ion may increase the excretion rate of SODIUM BICARBONATE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "SUFENTANIL may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "Ethylmorphine may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "morphine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "morphine may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "acemetacin", "drug2": "furosemide", "interaction_type": 65, "interaction_text": "acemetacin may increase the excretion rate of furosemide which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "REMIFENTANIL may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "DEZOCINE may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "levorphanol", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "levorphanol may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "codeine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "codeine may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "ALFENTANIL may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "butorphanol", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "butorphanol may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "methadone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "methadone may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "hydromorphone may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "buprenorphine may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "HEROIN", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "HEROIN may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "pentazocine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "pentazocine may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "lithium ion", "drug2": "sodium chloride", "interaction_type": 65, "interaction_text": "lithium ion may increase the excretion rate of sodium chloride which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "HYDROCODONE may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "DIPHENOXYLATE may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "meperidine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "meperidine may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "Ketobemidone may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "propoxyphene may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "Methadyl acetate may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "nalbuphine may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "DIHYDROCODEINE may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "Tapentadol may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "Tramadol", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "Tramadol may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "oxycodone", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 65, "interaction_text": "oxycodone may increase the excretion rate of AMMONIUM CHLORIDE which could result in a lower serum level and potentially a reduction in efficacy.", "severity": 2}
{"drug1": "Betrixaban", "drug2": "BENZYDAMINE", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with BENZYDAMINE.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "alclofenac", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with alclofenac.", "severity": 3}
{"drug1": "Apixaban", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Apixaban is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Olopatadine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Olopatadine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "ADAPALENE", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with ADAPALENE.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "sulindac", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with sulindac.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "citalopram", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with citalopram.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "floctafenine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with floctafenine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Sodium citrate", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Sodium citrate.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "chloroquine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with chloroquine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "epirizole", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with epirizole.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "mycophenolic acid", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with mycophenolic acid.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "nefazodone", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with nefazodone.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Etoricoxib", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Etoricoxib.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "carprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with carprofen.", "severity": 3}
{"drug1": "EDOXABAN", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when EDOXABAN is combined with acemetacin.", "severity": 3}
{"drug1": "dicumarol", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when dicumarol is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "diclofenac", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with diclofenac.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "oxaprozin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with oxaprozin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "antipyrine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with antipyrine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "tolmetin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with tolmetin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "fenbufen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with fenbufen.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "ETOFENAMATE", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with ETOFENAMATE.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "CLONIXIN", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with CLONIXIN.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "tolfenamic acid", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with tolfenamic acid.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Droxicam", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Droxicam.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Loxoprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Loxoprofen.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "niflumic acid", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with niflumic acid.", "severity": 3}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when PENTAERYTHRITOL TETRANITRATE is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Levomilnacipran", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Levomilnacipran.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "ZILEUTON", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with ZILEUTON.", "severity": 3}
{"drug1": "phenindione", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when phenindione is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "etodolac", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with etodolac.", "severity": 3}
{"drug1": "argatroban", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when argatroban is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Pimecrolimus", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Pimecrolimus.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "zaltoprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with zaltoprofen.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Aceclofenac", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Aceclofenac.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "SERATRODAST", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with SERATRODAST.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "oxyphenbutazone", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with oxyphenbutazone.", "severity": 3}
{"drug1": "pentosan polysulfate", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when pentosan polysulfate is combined with homoharringtonine.", "severity": 3}
{"drug1": "Apixaban", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Apixaban is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "ketoprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with ketoprofen.", "severity": 3}
{"drug1": "Rivaroxaban", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Rivaroxaban is combined with homoharringtonine.", "severity": 3}
{"drug1": "PENTAERYTHRITOL TETRANITRATE", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when PENTAERYTHRITOL TETRANITRATE is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Nepafenac", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Nepafenac.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Magnesium salicylate", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Magnesium salicylate.", "severity": 3}
{"drug1": "PHENPROCOUMON", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when PHENPROCOUMON is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Salsalate", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Salsalate.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Naftifine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Naftifine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "meclofenamic acid", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with meclofenamic acid.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "leflunomide", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with leflunomide.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "indomethacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with indomethacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "mesalamine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with mesalamine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Teriflunomide", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Teriflunomide.", "severity": 3}
{"drug1": "EDOXABAN", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when EDOXABAN is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "sulfasalazine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with sulfasalazine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Choline magnesium trisalicylate", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Choline magnesium trisalicylate.", "severity": 3}
{"drug1": "Fondaparinux", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Fondaparinux is combined with homoharringtonine.", "severity": 3}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when 3,4-Dihydroxybenzaldehyde is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Icatibant", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Icatibant.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Propacetamol", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Propacetamol.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "celecoxib", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with celecoxib.", "severity": 3}
{"drug1": "Dabigatran etexilate", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Dabigatran etexilate is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "mefenamic acid", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with mefenamic acid.", "severity": 3}
{"drug1": "Fondaparinux", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Fondaparinux is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Olsalazine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Olsalazine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "aspirin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with aspirin.", "severity": 3}
{"drug1": "Dabigatran etexilate", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Dabigatran etexilate is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "sertraline", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with sertraline.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "NAPROXEN", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with NAPROXEN.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "BALSALAZIDE", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with BALSALAZIDE.", "severity": 3}
{"drug1": "Rivaroxaban", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Rivaroxaban is combined with acemetacin.", "severity": 3}
{"drug1": "EDTA", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when EDTA is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Apremilast", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Apremilast.", "severity": 3}
{"drug1": "Bivalirudin", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Bivalirudin is combined with homoharringtonine.", "severity": 3}
{"drug1": "ACENOCOUMAROL", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when ACENOCOUMAROL is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "flurbiprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with flurbiprofen.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "paroxetine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with paroxetine.", "severity": 3}
{"drug1": "citric acid", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when citric acid is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Escitalopram", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Escitalopram.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "suprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with suprofen.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Lornoxicam", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Lornoxicam.", "severity": 3}
{"drug1": "phenindione", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when phenindione is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "azelastine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with azelastine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "diflunisal", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with diflunisal.", "severity": 3}
{"drug1": "Ximelagatran", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Ximelagatran is combined with homoharringtonine.", "severity": 3}
{"drug1": "EDTA", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when EDTA is combined with acemetacin.", "severity": 3}
{"drug1": "Ximelagatran", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Ximelagatran is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Milnacipran", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Milnacipran.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "fluvoxamine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with fluvoxamine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Masoprocol", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Masoprocol.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "PIRFENIDONE", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with PIRFENIDONE.", "severity": 3}
{"drug1": "pentosan polysulfate", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when pentosan polysulfate is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "fenoprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with fenoprofen.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "ketorolac", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with ketorolac.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "nabumetone", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with nabumetone.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "tenoxicam", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with tenoxicam.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "mycophenolate mofetil", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with mycophenolate mofetil.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Lumiracoxib", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Lumiracoxib.", "severity": 3}
{"drug1": "warfarin", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when warfarin is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "resveratrol", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with resveratrol.", "severity": 3}
{"drug1": "citric acid", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when citric acid is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "salicylamide", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with salicylamide.", "severity": 3}
{"drug1": "warfarin", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when warfarin is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "venlafaxine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with venlafaxine.", "severity": 3}
{"drug1": "Bivalirudin", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Bivalirudin is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "salicylic acid", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with salicylic acid.", "severity": 3}
{"drug1": "argatroban", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when argatroban is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "nimesulide", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with nimesulide.", "severity": 3}
{"drug1": "PHENPROCOUMON", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when PHENPROCOUMON is combined with homoharringtonine.", "severity": 3}
{"drug1": "dicumarol", "drug2": "homoharringtonine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when dicumarol is combined with homoharringtonine.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "tiaprofenic acid", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with tiaprofenic acid.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "duloxetine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with duloxetine.", "severity": 3}
{"drug1": "3,4-Dihydroxybenzaldehyde", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when 3,4-Dihydroxybenzaldehyde is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "fluoxetine", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with fluoxetine.", "severity": 3}
{"drug1": "ACENOCOUMAROL", "drug2": "acemetacin", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when ACENOCOUMAROL is combined with acemetacin.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "Rivaroxaban", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with Rivaroxaban.", "severity": 3}
{"drug1": "Betrixaban", "drug2": "ibuprofen", "interaction_type": 66, "interaction_text": "The risk or severity of bleeding can be increased when Betrixaban is combined with ibuprofen.", "severity": 3}
{"drug1": "cinoxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "clotrimazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of MAGNESIUM SULFATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "promethazine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "benzoic acid can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "estramustine", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "estramustine can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "raloxifene", "interaction_type": 67, "interaction_text": "L-thyroxine can cause a decrease in the absorption of raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "estramustine", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "estramustine can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "sulconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "trimetrexate can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "promethazine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Sertaconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "clotrimazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "dexlansoprazole", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of dexlansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "rapamycin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "rapamycin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of MAGNESIUM SULFATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "demeclocycline", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of demeclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "terconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "terconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "doxepin", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "Pazopanib can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "cimetidine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of cimetidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Miltefosine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "cimetidine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of cimetidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "Pazopanib can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Butoconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Asenapine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Asenapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "chlortetracycline", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of chlortetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "rabeprazole", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of rabeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "ranitidine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of ranitidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Lixisenatide", "interaction_type": 67, "interaction_text": "PHENPROCOUMON can cause a decrease in the absorption of Lixisenatide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "pentamidine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "pentamidine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "chlortetracycline", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of chlortetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "epinastine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of epinastine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "cholic acid can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "epinastine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of epinastine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Caspofungin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Lixisenatide", "interaction_type": 67, "interaction_text": "ACENOCOUMAROL can cause a decrease in the absorption of Lixisenatide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "butenafine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "butenafine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "cholic acid can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "itraconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "itraconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "promethazine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Posaconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "promethazine", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Magnesium salicylate", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Magnesium salicylate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Micafungin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Micafungin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ursodiol", "interaction_type": 67, "interaction_text": "nitrendipine can cause a decrease in the absorption of ursodiol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Asenapine", "interaction_type": 67, "interaction_text": "Pazopanib can cause a decrease in the absorption of Asenapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "ranitidine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of ranitidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "hexetidine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "hexetidine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "cyclosporin A can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "lansoprazole", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of lansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "CICLOPIROX can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "cyclosporin A can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "Magnesium salicylate", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of Magnesium salicylate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "oxiconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "estramustine", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "estramustine can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "pantoprazole", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of pantoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "dexlansoprazole", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of dexlansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "benzoic acid can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "rapamycin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "pantoprazole", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of pantoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Caspofungin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "doxepin", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "estramustine", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "estramustine can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "NATAMYCIN can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Anidulafungin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "EFINACONAZOLE can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "epinastine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of epinastine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "ketoconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Esomeprazole", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Esomeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "THYMOL", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "THYMOL can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "doxepin", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "FERRIC CITRATE", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of FERRIC CITRATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "promethazine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "epinastine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of epinastine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Magnesium salicylate", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Magnesium salicylate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "FERRIC PYROPHOSPHATE", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of FERRIC PYROPHOSPHATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Iron sucrose", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "estramustine", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "estramustine can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "tioconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "omeprazole", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of omeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "cimetidine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of cimetidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "trimetrexate can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nystatin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "nystatin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "5-Fluorocytosine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "ranitidine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of ranitidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "doxycycline", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "promethazine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "miconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "miconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Magnesium salicylate", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Magnesium salicylate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "terconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "terconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "haloprogin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "haloprogin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lincomycin", "drug2": "KAOLIN", "interaction_type": 67, "interaction_text": "lincomycin can cause a decrease in the absorption of KAOLIN resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "salicylic acid can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Esomeprazole", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Esomeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Artemether", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Artemether can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "amphotericin b can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Naftifine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Naftifine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "ranitidine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of ranitidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "estramustine", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "estramustine can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Esomeprazole", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Esomeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "pentamidine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cerulenin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "cerulenin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "Iron sucrose", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "FERRIC PYROPHOSPHATE", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of FERRIC PYROPHOSPHATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Naftifine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "terbinafine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Anidulafungin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "chloroxine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "butenafine", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "butenafine can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "THYMOL", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "THYMOL can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "lansoprazole", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of lansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "Pazopanib can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Isoconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "mequitazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sulconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "sulconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "cimetidine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of cimetidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "phenindione", "drug2": "Lixisenatide", "interaction_type": 67, "interaction_text": "phenindione can cause a decrease in the absorption of Lixisenatide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "bifonazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "bifonazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "FERRIC CITRATE", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of FERRIC CITRATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Voriconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fluconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "fluconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Artemether", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Artemether can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Posaconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "dexlansoprazole", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of dexlansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "omeprazole", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of omeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "griseofulvin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Micafungin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Micafungin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Voriconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Magnesium salicylate", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Magnesium salicylate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "FERRIC PYROPHOSPHATE", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of FERRIC PYROPHOSPHATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "doxepin", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "omeprazole", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of omeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Asenapine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Asenapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "amphotericin b can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "rabeprazole", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of rabeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Tavaborole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "salicylic acid can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "tolnaftate can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fluconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "fluconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "doxycycline", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nystatin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "nystatin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "MAGNESIUM SULFATE", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of MAGNESIUM SULFATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "doxepin", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Asenapine", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Asenapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Butoconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "MAGNESIUM SULFATE", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of MAGNESIUM SULFATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "oxiconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "Asenapine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of Asenapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "lansoprazole", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of lansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "cimetidine", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of cimetidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "pantoprazole", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of pantoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "estramustine", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "estramustine can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "EFINACONAZOLE can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "rabeprazole", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of rabeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Sertaconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "itraconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promethazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "promethazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "epinastine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of epinastine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "epinastine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of epinastine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "tioconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "tioconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "ketoconazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Iron sucrose", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "5-Fluorocytosine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "5-Fluorocytosine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Calcium citrate", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Calcium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "terbinafine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "terbinafine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "demeclocycline can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "lipoic acid can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "epinastine", "interaction_type": 67, "interaction_text": "Pazopanib can cause a decrease in the absorption of epinastine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "FERRIC CITRATE", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of FERRIC CITRATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "lansoprazole", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of lansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "pantoprazole", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of pantoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "CICLOPIROX can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "tolnaftate can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "ranitidine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of ranitidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "clindamycin", "drug2": "KAOLIN", "interaction_type": 67, "interaction_text": "clindamycin can cause a decrease in the absorption of KAOLIN resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "promethazine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "MORICIZINE can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "ROXATIDINE ACETATE", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of ROXATIDINE ACETATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Calcium phosphate", "interaction_type": 67, "interaction_text": "nalidixic acid can cause a decrease in the absorption of Calcium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Pefloxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Esomeprazole", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Esomeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ethambutol", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "ethambutol can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "cimetidine", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of cimetidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Lixisenatide", "interaction_type": 67, "interaction_text": "dicumarol can cause a decrease in the absorption of Lixisenatide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Calcium acetate", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of Calcium acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "methylene blue can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "griseofulvin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "ranitidine", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of ranitidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "dexlansoprazole", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of dexlansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "amiodarone", "drug2": "orlistat", "interaction_type": 67, "interaction_text": "amiodarone can cause a decrease in the absorption of orlistat resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "thioridazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of CALCIUM GLUCONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "famotidine", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cerulenin", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "cerulenin can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "doxepin", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "minocycline", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of minocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "trifluoperazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "demeclocycline", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of demeclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "LEVOFLOXACIN can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "periciazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "periciazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "minocycline", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "minocycline can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "Pazopanib can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "chlortetracycline can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "perphenazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "warfarin", "drug2": "Lixisenatide", "interaction_type": 67, "interaction_text": "warfarin can cause a decrease in the absorption of Lixisenatide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Aceprometazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "omeprazole", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of omeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "miconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "miconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "FLUPHENAZINE can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Levomepromazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "hexetidine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "hexetidine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "rabeprazole", "interaction_type": 67, "interaction_text": "Atazanavir can cause a decrease in the absorption of rabeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "Gatifloxacin can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "SODIUM BICARBONATE", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of SODIUM BICARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "isoniazid can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "nizatidine", "interaction_type": 67, "interaction_text": "Dasatinib can cause a decrease in the absorption of nizatidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "Iron sucrose can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Tavaborole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Glubionate calcium", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Glubionate calcium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "NATAMYCIN can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "Asenapine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of Asenapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "prochlorperazine can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "doxycycline", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "doxycycline can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "cinoxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "cholic acid can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "Sevelamer", "interaction_type": 67, "interaction_text": "Trovafloxacin can cause a decrease in the absorption of Sevelamer resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "FERRIC PYROPHOSPHATE can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Thioproperazine can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of MAGNESIUM HYDROXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "bifonazole", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "bifonazole can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Sodium phosphate monobasic", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "Sodium phosphate monobasic can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "fleroxacin can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "olanzapine", "interaction_type": 67, "interaction_text": "CEFPODOXIME can cause a decrease in the absorption of olanzapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "minocycline", "interaction_type": 67, "interaction_text": "FERRIC CITRATE can cause a decrease in the absorption of minocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "cimetidine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of cimetidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "triflupromazine can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Dipotassium hydrogen phosphate", "drug2": "CALCIUM CHLORIDE", "interaction_type": 67, "interaction_text": "Dipotassium hydrogen phosphate can cause a decrease in the absorption of CALCIUM CHLORIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "trimeprazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "ranitidine", "interaction_type": 67, "interaction_text": "cefuroxime can cause a decrease in the absorption of ranitidine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Magnesium trisilicate", "interaction_type": 67, "interaction_text": "mesoridazine can cause a decrease in the absorption of Magnesium trisilicate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Trometamol", "interaction_type": 67, "interaction_text": "allopurinol can cause a decrease in the absorption of Trometamol resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "Gemifloxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "mycophenolic acid can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Almasilate", "interaction_type": 67, "interaction_text": "norfloxacin can cause a decrease in the absorption of Almasilate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Magaldrate", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Magaldrate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "chloroxine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "chloroxine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Aluminium hydroxide", "interaction_type": 67, "interaction_text": "sparfloxacin can cause a decrease in the absorption of Aluminium hydroxide resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "Bismuth subcitrate potassium", "interaction_type": 67, "interaction_text": "ROSOXACIN can cause a decrease in the absorption of Bismuth subcitrate potassium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "haloprogin", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "haloprogin can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "didanosine", "interaction_type": 67, "interaction_text": "Miltefosine can cause a decrease in the absorption of didanosine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "Sucralfate", "interaction_type": 67, "interaction_text": "Isoconazole can cause a decrease in the absorption of Sucralfate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Asenapine", "interaction_type": 67, "interaction_text": "Delavirdine can cause a decrease in the absorption of Asenapine resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "Aluminium", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of Aluminium resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enoxacin", "drug2": "calcium lactate", "interaction_type": 67, "interaction_text": "enoxacin can cause a decrease in the absorption of calcium lactate resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "trientine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 67, "interaction_text": "trientine can cause a decrease in the absorption of MAGNESIUM OXIDE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "promazine", "drug2": "CALCIUM CARBONATE", "interaction_type": 67, "interaction_text": "promazine can cause a decrease in the absorption of CALCIUM CARBONATE resulting in a reduced serum concentration and potentially a decrease in efficacy.", "severity": 2}
{"drug1": "enalapril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "enalapril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "Olmesartan may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Spirapril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "irbesartan may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Drospirenone", "interaction_type": 68, "interaction_text": "AMILORIDE may increase the hyperkalemic activities of Drospirenone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "TASOSARTAN may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Olsalazine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Olsalazine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "suprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of suprofen.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "lisinopril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Eprosartan", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Eprosartan.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "cilazapril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Teriflunomide", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Teriflunomide.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "azelastine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of azelastine.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Sacubitril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "cilazapril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "benazepril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "benazepril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Candesartan cilexetil may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "quinapril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "quinapril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "niflumic acid", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of niflumic acid.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "MOEXIPRIL may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "valsartan", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "valsartan may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "irbesartan may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Sacubitril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Sacubitril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Loxoprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Loxoprofen.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Choline magnesium trisalicylate", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "valsartan", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of valsartan.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "NICORANDIL", "interaction_type": 68, "interaction_text": "Aliskiren may increase the hyperkalemic activities of NICORANDIL.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Masoprocol", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Masoprocol.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ramipril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of ramipril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "fenoprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of fenoprofen.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ADAPALENE", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of ADAPALENE.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Telmisartan may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "salicylic acid", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of salicylic acid.", "severity": 2}
{"drug1": "losartan", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "losartan may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "trandolapril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of trandolapril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "rescinnamine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of rescinnamine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "AMILORIDE", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of AMILORIDE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "TASOSARTAN", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of TASOSARTAN.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "irbesartan may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "chloroquine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of chloroquine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "TASOSARTAN", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of TASOSARTAN.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Spirapril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Spirapril.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "AMILORIDE may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "mycophenolate mofetil", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of mycophenolate mofetil.", "severity": 2}
{"drug1": "ramipril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "ramipril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "cilazapril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of cilazapril.", "severity": 2}
{"drug1": "captopril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "captopril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "ramipril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "ramipril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "TASOSARTAN may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "triamterene", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of triamterene.", "severity": 2}
{"drug1": "captopril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "captopril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "resveratrol", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of resveratrol.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "quinapril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "quinapril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "cilazapril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "lisinopril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "Eprosartan may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "TASOSARTAN may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "triamterene", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of triamterene.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Nepafenac", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Nepafenac.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "AMILORIDE", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of AMILORIDE.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Salsalate", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Salsalate.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "losartan", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of losartan.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "Eprosartan may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "fosinopril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "valsartan", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of valsartan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "tiaprofenic acid", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of tiaprofenic acid.", "severity": 2}
{"drug1": "fosinopril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "fosinopril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "captopril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of captopril.", "severity": 2}
{"drug1": "quinapril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "quinapril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "enalapril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "Sacubitril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "tolmetin", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of tolmetin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ibuprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of ibuprofen.", "severity": 2}
{"drug1": "benazepril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "benazepril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "triamterene", "drug2": "Sacubitril", "interaction_type": 68, "interaction_text": "triamterene may increase the hyperkalemic activities of Sacubitril.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "valsartan", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "valsartan may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "lisinopril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "lisinopril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "oxyphenbutazone", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of oxyphenbutazone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "MOEXIPRIL", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of MOEXIPRIL.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Drospirenone", "interaction_type": 68, "interaction_text": "Aliskiren may increase the hyperkalemic activities of Drospirenone.", "severity": 2}
{"drug1": "captopril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "captopril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "Olmesartan may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Olmesartan may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "enalapril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Olmesartan", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of Olmesartan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "Sacubitril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Olopatadine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Olopatadine.", "severity": 2}
{"drug1": "captopril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "captopril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nitrofurantoin", "interaction_type": 68, "interaction_text": "Eplerenone may increase the hyperkalemic activities of nitrofurantoin.", "severity": 2}
{"drug1": "triamterene", "drug2": "TASOSARTAN", "interaction_type": 68, "interaction_text": "triamterene may increase the hyperkalemic activities of TASOSARTAN.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "PIRFENIDONE", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of PIRFENIDONE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Eplerenone may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Icatibant", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Icatibant.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Pimecrolimus", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Pimecrolimus.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "Telmisartan may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "valsartan", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "valsartan may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "Sacubitril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "losartan", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "losartan may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "AMILORIDE may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "Telmisartan may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "TASOSARTAN", "interaction_type": 68, "interaction_text": "AMILORIDE may increase the hyperkalemic activities of TASOSARTAN.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "spironolactone", "drug2": "TASOSARTAN", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of TASOSARTAN.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "carprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of carprofen.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Lumiracoxib", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Lumiracoxib.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Olmesartan may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "fosinopril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "NICORANDIL", "interaction_type": 68, "interaction_text": "Sacubitril may increase the hyperkalemic activities of NICORANDIL.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Apremilast", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Apremilast.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "diflunisal", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of diflunisal.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "NICORANDIL", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of NICORANDIL.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "enalapril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of enalapril.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "Eprosartan may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "diclofenac", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of diclofenac.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "ramipril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "ramipril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "PERINDOPRIL may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "oxaprozin", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of oxaprozin.", "severity": 2}
{"drug1": "captopril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "captopril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "valsartan", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "valsartan may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "triamterene", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "triamterene may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Naftifine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Naftifine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "meclofenamic acid", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of meclofenamic acid.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "fosinopril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "PERINDOPRIL may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "indomethacin", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of indomethacin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Drospirenone", "interaction_type": 68, "interaction_text": "Eplerenone may increase the hyperkalemic activities of Drospirenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "mesalamine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of mesalamine.", "severity": 2}
{"drug1": "triamterene", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "triamterene may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Enalaprilat", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Enalaprilat.", "severity": 2}
{"drug1": "triamterene", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "triamterene may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "MOEXIPRIL may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "PERINDOPRIL may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "spironolactone", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "BENZYDAMINE", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of BENZYDAMINE.", "severity": 2}
{"drug1": "enalapril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "enalapril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "spironolactone", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of spironolactone.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "AMILORIDE", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of AMILORIDE.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "trandolapril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "Olmesartan may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "diltiazem", "drug2": "dantrolene", "interaction_type": 68, "interaction_text": "diltiazem may increase the hyperkalemic activities of dantrolene.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "trandolapril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Aliskiren may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ZILEUTON", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of ZILEUTON.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "etodolac", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of etodolac.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Sacubitril", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of Sacubitril.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "quinapril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "quinapril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "benazepril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "benazepril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Sacubitril", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of Sacubitril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "lisinopril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of lisinopril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "SERATRODAST", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of SERATRODAST.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Candesartan cilexetil", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Eprosartan may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "floctafenine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of floctafenine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "celecoxib", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of celecoxib.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "AMILORIDE may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "epirizole", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of epirizole.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "lisinopril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Telmisartan may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "NICORANDIL", "interaction_type": 68, "interaction_text": "Enalaprilat may increase the hyperkalemic activities of NICORANDIL.", "severity": 2}
{"drug1": "Eprosartan", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Eprosartan may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "PERINDOPRIL may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Candesartan cilexetil may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "Eplerenone may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "spironolactone", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of spironolactone.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "fosinopril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "Spirapril", "drug2": "NICORANDIL", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of NICORANDIL.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "salicylamide", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of salicylamide.", "severity": 2}
{"drug1": "benazepril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "benazepril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "PERINDOPRIL may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "dantrolene", "interaction_type": 68, "interaction_text": "VERAPAMIL may increase the hyperkalemic activities of dantrolene.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "Eplerenone may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "TASOSARTAN may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "MOEXIPRIL may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Etoricoxib", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Etoricoxib.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "nimesulide", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of nimesulide.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ETOFENAMATE", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of ETOFENAMATE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "irbesartan may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "valsartan", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "valsartan may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "antipyrine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of antipyrine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "alclofenac", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of alclofenac.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "quinapril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of quinapril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "benazepril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of benazepril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "flurbiprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of flurbiprofen.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "leflunomide", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of leflunomide.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "fosinopril", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of fosinopril.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "TASOSARTAN may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "CLONIXIN", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of CLONIXIN.", "severity": 2}
{"drug1": "enalapril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "enalapril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Eprosartan", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of Eprosartan.", "severity": 2}
{"drug1": "spironolactone", "drug2": "triamterene", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of triamterene.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "fenbufen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of fenbufen.", "severity": 2}
{"drug1": "losartan", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "losartan may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "tolfenamic acid", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of tolfenamic acid.", "severity": 2}
{"drug1": "Spirapril", "drug2": "triamterene", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of triamterene.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "PERINDOPRIL", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of PERINDOPRIL.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Droxicam", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Droxicam.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "sulfasalazine", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of sulfasalazine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "BALSALAZIDE", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of BALSALAZIDE.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Lornoxicam", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Lornoxicam.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "Telmisartan may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "trandolapril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "trandolapril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "zaltoprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of zaltoprofen.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Drospirenone", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of Drospirenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Aceclofenac", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Aceclofenac.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "trandolapril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "AMILORIDE", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of AMILORIDE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "irbesartan may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "nitrofurantoin", "interaction_type": 68, "interaction_text": "spironolactone may increase the hyperkalemic activities of nitrofurantoin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "MOEXIPRIL may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "rescinnamine", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "rescinnamine may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "trandolapril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "losartan", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "losartan may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "Sacubitril", "interaction_type": 68, "interaction_text": "AMILORIDE may increase the hyperkalemic activities of Sacubitril.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ketorolac", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of ketorolac.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Olmesartan", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Olmesartan.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "sulindac", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of sulindac.", "severity": 2}
{"drug1": "quinapril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "quinapril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "nabumetone", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of nabumetone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Telmisartan", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of Telmisartan.", "severity": 2}
{"drug1": "ramipril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "ramipril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "losartan", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "losartan may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Propacetamol", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Propacetamol.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "tenoxicam", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of tenoxicam.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "mefenamic acid", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of mefenamic acid.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "aspirin", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of aspirin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Aliskiren", "interaction_type": 68, "interaction_text": "lisinopril may increase the hyperkalemic activities of Aliskiren.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "NAPROXEN", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of NAPROXEN.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ketoprofen", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of ketoprofen.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Telmisartan", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Telmisartan.", "severity": 2}
{"drug1": "Sacubitril", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "Sacubitril may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "tacrolimus may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "ramipril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "ramipril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "MOEXIPRIL may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "irbesartan", "interaction_type": 68, "interaction_text": "cyclosporin A may increase the hyperkalemic activities of irbesartan.", "severity": 2}
{"drug1": "triamterene", "drug2": "Drospirenone", "interaction_type": 68, "interaction_text": "triamterene may increase the hyperkalemic activities of Drospirenone.", "severity": 2}
{"drug1": "Spirapril", "drug2": "spironolactone", "interaction_type": 68, "interaction_text": "Spirapril may increase the hyperkalemic activities of spironolactone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Magnesium salicylate", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of Magnesium salicylate.", "severity": 2}
{"drug1": "benazepril", "drug2": "Canagliflozin", "interaction_type": 68, "interaction_text": "benazepril may increase the hyperkalemic activities of Canagliflozin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "NICORANDIL", "interaction_type": 68, "interaction_text": "TASOSARTAN may increase the hyperkalemic activities of NICORANDIL.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Eplerenone", "interaction_type": 68, "interaction_text": "cilazapril may increase the hyperkalemic activities of Eplerenone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Tolvaptan", "interaction_type": 68, "interaction_text": "cilazapril may increase the hyperkalemic activities of Tolvaptan.", "severity": 2}
{"drug1": "AZILSARTAN MEDOXOMIL", "drug2": "trimethoprim", "interaction_type": 68, "interaction_text": "AZILSARTAN MEDOXOMIL may increase the hyperkalemic activities of trimethoprim.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "irbesartan", "interaction_type": 68, "interaction_text": "Drospirenone may increase the hyperkalemic activities of irbesartan.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "codeine", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "methadone", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "methadone may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "morphine", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "morphine", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "codeine", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "codeine", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "Normethadone", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "morphine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "codeine", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "levorphanol", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "butorphanol", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "morphine", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "methadone", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "methadone may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "morphine", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "oxymorphone may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "codeine", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "methadone", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "methadone may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "meperidine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "codeine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "meperidine may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "codeine", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "levorphanol", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "pentazocine", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "methadone", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "methadone may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "HEROIN", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "pentazocine", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "HEROIN", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "HEROIN may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "codeine", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "Tramadol may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "DIHYDROCODEINE may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "SUFENTANIL may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "morphine", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "morphine", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "ALFENTANIL may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "hydromorphone may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "codeine", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "codeine may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "butorphanol", "drug2": "AMPHETAMINE", "interaction_type": 69, "interaction_text": "butorphanol may increase the analgesic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "methadone", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "methadone may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "levorphanol", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "levorphanol may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "DIPHENOXYLATE", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "DIPHENOXYLATE may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "pentazocine", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "pentazocine may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "DEZOCINE", "drug2": "benzphetamine", "interaction_type": 69, "interaction_text": "DEZOCINE may increase the analgesic activities of benzphetamine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "oxycodone may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "Normethadone", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "Normethadone may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "Ethylmorphine may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "propoxyphene may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "nalbuphine", "drug2": "Amfepramone", "interaction_type": 69, "interaction_text": "nalbuphine may increase the analgesic activities of Amfepramone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "MEPHENTERMINE", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "dextroamphetamine", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of dextroamphetamine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "METHAMPHETAMINE", "interaction_type": 69, "interaction_text": "buprenorphine may increase the analgesic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "Ketobemidone may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "REMIFENTANIL", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "REMIFENTANIL may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "HYDROCODONE may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "morphine", "drug2": "Lisdexamfetamine", "interaction_type": 69, "interaction_text": "morphine may increase the analgesic activities of Lisdexamfetamine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 69, "interaction_text": "Tapentadol may increase the analgesic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Methadyl acetate", "drug2": "hydroxyamphetamine", "interaction_type": 69, "interaction_text": "Methadyl acetate may increase the analgesic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "Lymecycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lymecycline.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "carprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with mequitazine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "carbamazepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carbamazepine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with benzphetamine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with diflorasone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Magnesium trisilicate.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "digoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of digoxin can be decreased when used in combination with AMILORIDE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "methicillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with methicillin.", "severity": 2}
{"drug1": "piperazine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "amcinonide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amcinonide can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "triprolidine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with triprolidine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "FLUPHENAZINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of FLUPHENAZINE can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "goserelin", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "goserelin", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with dipivefrin.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with dextroamphetamine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "phenytoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenytoin can be decreased when used in combination with ciprofloxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "nabumetone", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Tiludronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiludronic Acid can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "indapamide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "primidone", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Dienogest", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "ambenonium", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "budesonide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with budesonide.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Cobicistat.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "mianserin", "drug2": "METHSUXIMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of METHSUXIMIDE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ropinirole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ropinirole can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "betahistine", "drug2": "isoproterenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isoproterenol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "clozapine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Clevidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clevidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "famotidine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with famotidine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Amrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Amrinone can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "amantadine", "drug2": "haloperidol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of haloperidol can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "adenosine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of adenosine can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "chlormezanone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlormezanone can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Acitretin", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "triamterene", "drug2": "digoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of digoxin can be decreased when used in combination with triamterene.", "severity": 2}
{"drug1": "chloroquine", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with benzoic acid.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "progesterone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "resveratrol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "resveratrol", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Miltefosine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Tixocortol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "nifedipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with nifedipine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "Fluspirilene", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Fluspirilene.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with tizanidine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "Almasilate", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with Almasilate.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with difluprednate.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "ritonavir", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Asenapine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Pinaverium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pinaverium can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with PROCATEROL.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Tiludronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiludronic Acid can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "tetracycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with tetracycline.", "severity": 2}
{"drug1": "ritonavir", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with RIMEXOLONE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "primidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of primidone can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "goserelin", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "salicylamide", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with nalidixic acid.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with clofazimine.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "naltrexone", "drug2": "SUFENTANIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of SUFENTANIL can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with RIFABUTIN.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "aspirin", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Lofexidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lofexidine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "histrelin", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "floctafenine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "histrelin", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Gatate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gatate can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with RANOLAZINE.", "severity": 2}
{"drug1": "ROLITETRACYCLINE", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with guanabenz.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "levodopa", "drug2": "haloperidol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of haloperidol can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "bumetanide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Azelnidipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "diflunisal", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "manidipine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with manidipine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "clozapine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "Demecarium", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "nitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrazepam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with DEFLAZACORT.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "galanthamine", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "malathion", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "estradiol", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "Apremilast", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "progesterone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "levodopa", "drug2": "pimozide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pimozide can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "amobarbital", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with isoproterenol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "nimesulide", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Rotigotine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rotigotine can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "Salsalate", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Cis-mdp", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Cis-mdp can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "danazol", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Naftifine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with ketoconazole.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "folinic acid", "drug2": "Raltitrexed", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Raltitrexed can be decreased when used in combination with folinic acid.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "zotepine", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with zotepine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Pimavanserin", "drug2": "pramipexole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pramipexole can be decreased when used in combination with Pimavanserin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Droxicam", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with Almasilate.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Pipamperone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pipamperone can be decreased when used in combination with cabergoline.", "severity": 2}
{"drug1": "resveratrol", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "aspirin", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "PAMIDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PAMIDRONIC ACID can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "norethindrone", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "estrone", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "ambenonium", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with clotrimazole.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with nevirapine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Enalaprilat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Enalaprilat can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Halobetasol.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "cefepime", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefepime.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "hexetidine", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with hexetidine.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with QUINESTROL.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "pyrimethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pyrimethamine can be decreased when used in combination with Levomefolic acid.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Clodronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clodronic Acid can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "periciazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of periciazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "donepezil", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "danazol", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "etodolac", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "betahistine", "drug2": "Salbutamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Salbutamol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with hydroxyamphetamine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "thiopental", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "piperazine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "ceritinib", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "amoxapine", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "Icatibant", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "disulfiram", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of disulfiram can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Risedronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Risedronic acid can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "carprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "metolazone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Deferasirox", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Deferasirox can be decreased when used in combination with Aluminium hydroxide.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "primidone", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "acetyldigitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetyldigitoxin can be decreased when used in combination with Eplerenone.", "severity": 2}
{"drug1": "aminophylline", "drug2": "clorazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clorazepate can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "barnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of barnidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "lincomycin", "drug2": "erythromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of erythromycin can be decreased when used in combination with lincomycin.", "severity": 2}
{"drug1": "ambenonium", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "thiopental", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Dienogest", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "risperidone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "decamethonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of decamethonium can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "mefloquine", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "betahistine", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with duloxetine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "METHSUXIMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of METHSUXIMIDE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mianserin", "drug2": "clonazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonazepam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "ouabain", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ouabain can be decreased when used in combination with AMILORIDE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "metolazone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "goserelin", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with thioridazine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "clozapine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bedaquiline.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "malathion", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Naftifine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Retapamulin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with Magnesium trisilicate.", "severity": 2}
{"drug1": "carprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "oxacillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with oxacillin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Demecarium", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "mianserin", "drug2": "diazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazepam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "norethindrone", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "naltrexone", "drug2": "oxycodone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxycodone can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Lofexidine.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "suprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "betamethasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with Magaldrate.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "sulindac", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "olanzapine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "sulindac", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "nabumetone", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "formestane", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with formestane.", "severity": 2}
{"drug1": "risperidone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "valsartan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of valsartan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "ramipril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ramipril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with terbinafine.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Ketobemidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ketobemidone can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Micafungin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Micafungin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with griseofulvin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Risedronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Risedronic acid can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "primidone", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "betaxolol", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with betaxolol.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Fluticasone furoate.", "severity": 2}
{"drug1": "Lodoxamide", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Lodoxamide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with dihydroergotamine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Delorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Delorazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "olanzapine", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Amrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Amrinone can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "clozapine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "memantine", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with cocaine.", "severity": 2}
{"drug1": "CEFONICID", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with CEFONICID.", "severity": 2}
{"drug1": "metolazone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with flumethasone.", "severity": 2}
{"drug1": "thonzylamine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with thonzylamine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "haloperidol", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with haloperidol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "moxifloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with moxifloxacin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Bethanidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bethanidine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "ADEFOVIR DIPIVOXIL", "drug2": "Tenofovir disoproxil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tenofovir disoproxil can be decreased when used in combination with ADEFOVIR DIPIVOXIL.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "memantine", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "risperidone", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "memantine", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "risperidone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "triamcinolone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of triamcinolone can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "estriol", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with estriol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "estazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estazolam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "edrophonium", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "alclofenac", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "phenacemide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenacemide can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "tibolone", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with azithromycin.", "severity": 2}
{"drug1": "amobarbital", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "imipramine", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with imipramine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with sertraline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "metoclopramide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metoclopramide can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "naphazoline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with naphazoline.", "severity": 2}
{"drug1": "celecoxib", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "thioridazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thioridazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "amisulpride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amisulpride can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "diflunisal", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "acemetacin", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "aztreonam", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with aztreonam.", "severity": 2}
{"drug1": "Ozenoxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ozenoxacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "galanthamine", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "enoxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with enoxacin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "PARAMETHADIONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PARAMETHADIONE can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "fluocinonide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fluocinonide can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "primidone", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Rotigotine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rotigotine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "epinastine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with epinastine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "penicillin g", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin g can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "piperazine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Pinaverium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pinaverium can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "bupropion", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with bupropion.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "sulindac", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "apomorphine", "drug2": "perphenazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of perphenazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "thiopental", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "sulconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with sulconazole.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "indinavir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "promethazine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with promethazine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "meprobamate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of meprobamate can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "indapamide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Rufinamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rufinamide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with MEZLOCILLIN.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Etidronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Etidronic acid can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "thiopental", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "diazoxide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "carprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Blonanserin", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Blonanserin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "chlorprothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorprothixene can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with flunisolide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "betahistine", "drug2": "ritodrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ritodrine can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Azelnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Azelnidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "edrophonium", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "mianserin", "drug2": "vigabatrin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of vigabatrin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "deslanoside", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of deslanoside can be decreased when used in combination with AMILORIDE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Acitretin", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ondansetron", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ondansetron can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "naltrexone", "drug2": "buprenorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of buprenorphine can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "histrelin", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Naftifine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with CLOCORTOLONE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "minocycline", "drug2": "methicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methicillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Levomilnacipran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levomilnacipran can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with fluvoxamine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "zafirlukast", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of zafirlukast can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "minocycline", "drug2": "Tazobactam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tazobactam can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "donepezil", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "mianserin", "drug2": "thiopental", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiopental can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "methacycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with methacycline.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Mephobarbital", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Mephobarbital can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "mestranol", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "brimonidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of brimonidine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "furosemide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "furosemide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "nabumetone", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "guanabenz", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of guanabenz can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Escitalopram", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Escitalopram can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "nifedipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nifedipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "Droxicam", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Mersalyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Mersalyl can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "sulindac", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with tetrahydrozoline.", "severity": 2}
{"drug1": "equilin", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with equilin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "triazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of triazolam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "epinephrine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "minocycline", "drug2": "Flucloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Perampanel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Perampanel can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "memantine", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "edrophonium", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "thiopental", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "mianserin", "drug2": "topiramate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of topiramate can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "VORTIOXETINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VORTIOXETINE can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with Levomilnacipran.", "severity": 2}
{"drug1": "fusidic acid", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with fusidic acid.", "severity": 2}
{"drug1": "Darunavir", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Darunavir", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "alclofenac", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Naftifine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "etodolac", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "ketorolac", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "prednisone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with clindamycin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "edrophonium", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Demecarium", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "acemetacin", "drug2": "acetazolamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetazolamide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Amrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Amrinone can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "tolfenamic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolfenamic acid can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "budesonide", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with budesonide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with Escitalopram.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "nifedipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nifedipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "indapamide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Nonoxynol-9", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Nonoxynol-9 can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "dienestrol", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with dienestrol.", "severity": 2}
{"drug1": "carprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Mometasone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "barnidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with barnidipine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "danazol", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "VIOMYCIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with VIOMYCIN.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "malathion", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "haloperidol", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with haloperidol.", "severity": 2}
{"drug1": "cephalothin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cephalothin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Arformoterol.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Ciclesonide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Clomocycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with Clomocycline.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "sulindac", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "tolmetin", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "rapamycin", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Articaine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "altretamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of altretamine can be decreased when used in combination with pyridoxine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "penicillin v", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin v can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "ampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ampicillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "estradiol", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "loratadine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with loratadine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with PREDNICARBATE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "azelastine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "betahistine", "drug2": "Bambuterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bambuterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "betahistine", "drug2": "clenbuterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clenbuterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with Amfepramone.", "severity": 2}
{"drug1": "mestranol", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "amantadine", "drug2": "trifluoperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trifluoperazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "ALENDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ALENDRONIC ACID can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "CLAVULANIC ACID", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with CLAVULANIC ACID.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "amantadine", "drug2": "MOLINDONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOLINDONE can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "TRIETHANOLAMINE", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with TRIETHANOLAMINE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "goserelin", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "etodolac", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "toremifene", "drug2": "Sugammadex", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sugammadex can be decreased when used in combination with toremifene.", "severity": 2}
{"drug1": "physostigmine", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "ceftazidime", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ceftazidime.", "severity": 2}
{"drug1": "diclofenac", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "estradiol", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with chloramphenicol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Nomegestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "VALPROIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VALPROIC ACID can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "diltiazem", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with diltiazem.", "severity": 2}
{"drug1": "Apremilast", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "mianserin", "drug2": "benzphetamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzphetamine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Besifloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Besifloxacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "leflunomide", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "cyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclothiazide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "VERAPAMIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VERAPAMIL can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "dyphylline", "drug2": "triazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of triazolam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "Dienogest", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with fluocinonide.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with brimonidine.", "severity": 2}
{"drug1": "etodolac", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "ceritinib", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "diazoxide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "Octreotide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Clobetasone.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "barnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of barnidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "indapamide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "alprazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprazolam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with norfloxacin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with trandolapril.", "severity": 2}
{"drug1": "alclofenac", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "norethindrone", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "PERHEXILINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERHEXILINE can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "epirizole", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "metolazone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with Aluminium.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "medrysone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with medrysone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with trimipramine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Dienogest", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "mianserin", "drug2": "Lofexidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lofexidine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "mianserin", "drug2": "phenytoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenytoin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "betahistine", "drug2": "PROCATEROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PROCATEROL can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "pramipexole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pramipexole can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "mesalamine", "drug2": "probenecid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of probenecid can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with ketoconazole.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Apremilast", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "physostigmine", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "nilutamide", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with nilutamide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "physostigmine", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "decamethonium", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "ambenonium", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with haloperidol.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "carprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "carprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "mianserin", "drug2": "phenacemide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenacemide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "droperidol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of droperidol can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "flunisolide", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with flunisolide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Sitaxsentan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitaxsentan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "lipoic acid", "drug2": "cisplatin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cisplatin can be decreased when used in combination with lipoic acid.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Ulipristal", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ulipristal can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "piperazine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with nefazodone.", "severity": 2}
{"drug1": "piperazine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "CEFORANIDE", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with CEFORANIDE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "donepezil", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with diflorasone.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "ranitidine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with ranitidine.", "severity": 2}
{"drug1": "goserelin", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "alclofenac", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "suprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "celecoxib", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "floctafenine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "sertraline", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with sertraline.", "severity": 2}
{"drug1": "etodolac", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "donepezil", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Penicillin G benzathine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Penicillin G benzathine can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "suprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "SULBACTAM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of SULBACTAM can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "VERAPAMIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VERAPAMIL can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Retigabine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Retigabine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "suprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "etizolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of etizolam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "epirizole", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "edrophonium", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "chloroquine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with VALPROIC ACID.", "severity": 2}
{"drug1": "pramipexole", "drug2": "Thioproperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Thioproperazine can be decreased when used in combination with pramipexole.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "decamethonium", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "nimesulide", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Tiludronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiludronic Acid can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Canrenoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canrenoic acid can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "VERAPAMIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VERAPAMIL can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "temazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of temazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with bicalutamide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "etodolac", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "cephradine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cephradine.", "severity": 2}
{"drug1": "amantadine", "drug2": "perphenazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of perphenazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with chlorpheniramine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "mefloquine", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "clonazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonazepam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "amphotericin b", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with amphotericin b.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "promethazine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with promethazine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with metronidazole.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Atomoxetine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with ondansetron.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Mometasone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Mometasone can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "DIMENHYDRINATE", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with DIMENHYDRINATE.", "severity": 2}
{"drug1": "donepezil", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "tibolone", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "mestranol", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Gestrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gestrinone can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with levonordefrin.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with flurandrenolide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "danazol", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "danazol", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "mestranol", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Penicillin G benzathine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "secobarbital", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "acemetacin", "drug2": "betaxolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betaxolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Quinine.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with diethylstilbestrol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "sulindac", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "salicylamide", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Abiraterone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Abiraterone can be decreased when used in combination with spironolactone.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "mifepristone", "drug2": "desoximetasone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of desoximetasone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "estradiol", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with CLOCORTOLONE.", "severity": 2}
{"drug1": "terbinafine", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with terbinafine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Benidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Benidipine.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with PERHEXILINE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Fluprednidene.", "severity": 2}
{"drug1": "piperazine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Eplerenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Eplerenone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Methadyl acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methadyl acetate can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "Aluminium", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Aluminium.", "severity": 2}
{"drug1": "Bethanidine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Bethanidine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "epinastine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with epinastine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with paramethasone.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "danazol", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "felodipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with felodipine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Demecarium", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "methoxamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with methoxamine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "Torasemide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "clozapine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with phenmetrazine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "Fusafungine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fusafungine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "progesterone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "mianserin", "drug2": "Perampanel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Perampanel can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "nafcillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nafcillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "Icatibant", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with alclometasone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "edrophonium", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "edrophonium", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "acetazolamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetazolamide can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "edrophonium", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "edrophonium", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "ranitidine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with ranitidine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "pyridostigmine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pyridostigmine can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "amprenavir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with amprenavir.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "diflorasone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diflorasone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with Levomilnacipran.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with RIMEXOLONE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "manidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with manidipine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "nimesulide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimesulide can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "formestane", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with formestane.", "severity": 2}
{"drug1": "tolmetin", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Alcaftadine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Alcaftadine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with fluocinonide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "theophylline", "drug2": "nitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "salicylamide", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "prochlorperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prochlorperazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "cinnarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cinnarizine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with Escitalopram.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mifepristone", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "flumazenil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flumazenil can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "memantine", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Dirithromycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dirithromycin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "cephapirin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cephapirin.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Spectinomycin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Olmesartan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Olmesartan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "temazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of temazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "salicylamide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "Bortezomib", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bortezomib can be decreased when used in combination with l-ascorbic acid.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "apomorphine", "drug2": "trifluoperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trifluoperazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "sulindac", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Enalaprilat.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "VERAPAMIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VERAPAMIL can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "periciazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of periciazine can be decreased when used in combination with pramipexole.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with amoxicillin.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "histrelin", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "propylthiouracil", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with propylthiouracil.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ribostamycin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Salsalate", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Dienogest", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "bumetanide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "etodolac", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "goserelin", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "metolazone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Tixocortol.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Oxilofrine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Oxilofrine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with DEFLAZACORT.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "nimesulide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimesulide can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "sertraline", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with sertraline.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Oritavancin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Oritavancin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "zidovudine", "drug2": "stavudine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of stavudine can be decreased when used in combination with zidovudine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Acitretin", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "doxycycline", "drug2": "SULBACTAM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of SULBACTAM can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "floctafenine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Penicillin G benzathine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Penicillin G benzathine can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "progesterone", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "progesterone", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "aspirin", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ZILEUTON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ZILEUTON can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with NATAMYCIN.", "severity": 2}
{"drug1": "piperazine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "doxycycline", "drug2": "piperacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of piperacillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "novobiocin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with novobiocin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "levodopa", "drug2": "chlorprothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorprothixene can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "epinephrine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "donepezil", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "norethindrone", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "Droxicam", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "etodolac", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "aspirin", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Quinagolide", "drug2": "Pipamperone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pipamperone can be decreased when used in combination with Quinagolide.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with Milnacipran.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "chloroxine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with chloroxine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with Almasilate.", "severity": 2}
{"drug1": "aspirin", "drug2": "probenecid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of probenecid can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Lacidipine.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "suprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "progesterone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "malathion", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with difluprednate.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "clofibrate", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with clofibrate.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Fluprednidene.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with sparfloxacin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Ibandronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ibandronic Acid can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "mianserin", "drug2": "Ifenprodil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ifenprodil can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with isoniazid.", "severity": 2}
{"drug1": "naltrexone", "drug2": "HEROIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of HEROIN can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Blonanserin", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with Blonanserin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with tranylcypromine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "furosemide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with fluocinonide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with diflorasone.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "malathion", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "mianserin", "drug2": "riluzole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of riluzole can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "paramethasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with paramethasone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "thiothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiothixene can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Thioproperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Thioproperazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Zuclopenthixol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zuclopenthixol can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "mianserin", "drug2": "PARALDEHYDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PARALDEHYDE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "mianserin", "drug2": "Eslicarbazepine acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with alclometasone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "oxprenolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxprenolol can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "KETAZOLAM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of KETAZOLAM can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "prazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "mianserin", "drug2": "Etomidate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Etomidate can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with METHAMPHETAMINE.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "epirizole", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "lorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lorazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Clobetasone.", "severity": 2}
{"drug1": "cefotetan", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefotetan.", "severity": 2}
{"drug1": "Asenapine", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "carprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "thiopental", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Tianeptine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "cimetidine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with cimetidine.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "prednisone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "norethindrone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Progabide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Progabide can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Phensuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Phensuximide can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "doxycycline", "drug2": "cloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cloxacillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "metolazone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Cyamemazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Cyamemazine can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with bezafibrate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "memantine", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "doxepin", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with doxepin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "physostigmine", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Aceprometazine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "flunarizine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with flunarizine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "physostigmine", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "fludiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludiazepam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "physostigmine", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Articaine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with PROCATEROL.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Conivaptan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Conivaptan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Eprosartan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Eprosartan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "Acitretin", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "tizanidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tizanidine can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Delorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Delorazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Azelnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Azelnidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Benidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Benidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "levodopa", "drug2": "amisulpride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amisulpride can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "theophylline", "drug2": "flumazenil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flumazenil can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "periciazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with periciazine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "theophylline", "drug2": "clonazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "olanzapine", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "sulindac", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "terbutaline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with terbutaline.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "fludiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludiazepam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "ambenonium", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "acemetacin", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "sulfacetamide", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with sulfacetamide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with droxidopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "promazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of promazine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "aminophylline", "drug2": "midazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of midazolam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with clarithromycin.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "allylestrenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of allylestrenol can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "diazoxide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with prochlorperazine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "fenbufen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "fenbufen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with flurandrenolide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with cyclobenzaprine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "sulindac", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with diethylstilbestrol.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "mianserin", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with spironolactone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Perospirone.", "severity": 2}
{"drug1": "Lymecycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with Lymecycline.", "severity": 2}
{"drug1": "prednisone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Acitretin", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "diflunisal", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "diflunisal", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "clemastine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with clemastine.", "severity": 2}
{"drug1": "isradipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with isradipine.", "severity": 2}
{"drug1": "epirizole", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "doxycycline", "drug2": "dicloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicloxacillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "budesonide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with budesonide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "phenobarbital", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenobarbital can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Ciclesonide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ciclesonide can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "indinavir", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "mefloquine", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "meprobamate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of meprobamate can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Etomidate", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Etomidate.", "severity": 2}
{"drug1": "Acitretin", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with nefazodone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with DEFLAZACORT.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Fluticasone furoate.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with diphenhydramine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Carbamylcholine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Carbamylcholine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Nitroprusside", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Nitroprusside can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "donepezil", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with nafcillin.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "indomethacin", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "malathion", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "resveratrol", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "sertraline", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with sertraline.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fidaxomicin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with DESONIDE.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with ropinirole.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "levodopa", "drug2": "MOLINDONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOLINDONE can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "cinnarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cinnarizine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with CLOCORTOLONE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with desoximetasone.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with Lisdexamfetamine.", "severity": 2}
{"drug1": "danazol", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "aspirin", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "Ertapenem", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ertapenem.", "severity": 2}
{"drug1": "Icatibant", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "salicylamide", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "terconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with terconazole.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "amantadine", "drug2": "loxapine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of loxapine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Penicillin G benzathine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Penicillin G benzathine can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "SULBACTAM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of SULBACTAM can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "Asenapine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "furosemide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "Articaine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Mirabegron.", "severity": 2}
{"drug1": "bumetanide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "tioconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with tioconazole.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "aminophylline", "drug2": "chlordiazepoxide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlordiazepoxide can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "epinephrine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "CYPROTERONE ACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYPROTERONE ACETATE can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Articaine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "mestranol", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "goserelin", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "oxazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "prednisone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "prednisone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "epinastine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with epinastine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "duloxetine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of duloxetine can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Gramicidin D", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gramicidin D.", "severity": 2}
{"drug1": "acemetacin", "drug2": "theobromine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of theobromine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "mianserin", "drug2": "apraclonidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apraclonidine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "zaleplon", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of zaleplon can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "METHSUXIMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of METHSUXIMIDE can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "aspirin", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "danazol", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "omeprazole", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with SERTINDOLE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "etodolac", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "loxapine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of loxapine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with doxepin.", "severity": 2}
{"drug1": "tibolone", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "mifepristone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mifepristone can be decreased when used in combination with DEXKETOPROFEN.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "eperisone", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with eperisone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "mestranol", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with diethylstilbestrol.", "severity": 2}
{"drug1": "risperidone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "Fenofibric acid", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with Fenofibric acid.", "severity": 2}
{"drug1": "acemetacin", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "minocycline", "drug2": "nafcillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nafcillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "aspirin", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with paroxetine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Risedronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Risedronic acid can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "ritonavir", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "cinnarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cinnarizine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "dyphylline", "drug2": "clorazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clorazepate can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Ibandronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ibandronic Acid can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "levodopa", "drug2": "loxapine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of loxapine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with PREDNICARBATE.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "tibolone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tibolone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "memantine", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with FLUOCORTOLONE.", "severity": 2}
{"drug1": "tolmetin", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "azelastine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "malathion", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of malathion can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "goserelin", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "ALENDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ALENDRONIC ACID can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with RIMEXOLONE.", "severity": 2}
{"drug1": "furosemide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "thiopental", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "furosemide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "flunisolide", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with flunisolide.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "piperacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of piperacillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Lorcaserin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "progesterone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "epirizole", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "metolazone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with diphenhydramine.", "severity": 2}
{"drug1": "ceftibuten", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ceftibuten.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "clemastine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with clemastine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Tixocortol.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "diazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazepam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "formoterol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with formoterol.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "histrelin", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with venlafaxine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "acemetacin", "drug2": "spironolactone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of spironolactone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "naltrexone", "drug2": "meperidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of meperidine can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "mianserin", "drug2": "levonordefrin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levonordefrin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "quetiapine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Dexrazoxane", "drug2": "doxorubicin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of doxorubicin can be decreased when used in combination with Dexrazoxane.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Miltefosine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Miltefosine.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with desoximetasone.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "theophylline", "drug2": "Lormetazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lormetazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "Tavaborole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Tavaborole.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "acemetacin", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "DESERPIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESERPIDINE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "tretinoin", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "nabumetone", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "azelastine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Zoledronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zoledronic acid can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "amcinonide", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with amcinonide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "azlocillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with azlocillin.", "severity": 2}
{"drug1": "histrelin", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "histrelin", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with MELPERONE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "primidone", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with difluprednate.", "severity": 2}
{"drug1": "donepezil", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "malathion", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "betahistine", "drug2": "ARBUTAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ARBUTAMINE can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "temazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of temazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "PAMIDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PAMIDRONIC ACID can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "flunitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunitrazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ethyl loflazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethyl loflazepate can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Articaine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "nimesulide", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "amantadine", "drug2": "promazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of promazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "malathion", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "buspirone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of buspirone can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "indinavir", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "nimesulide", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "PAMIDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PAMIDRONIC ACID can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Ibandronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ibandronic Acid can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "ketorolac", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "leflunomide", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "metolazone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "metolazone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "piperazine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "ACRIVASTINE", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with ACRIVASTINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "diazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "risperidone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "naltrexone", "drug2": "nalbuphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nalbuphine can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "carprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "edrophonium", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "edrophonium", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "vitamin B12", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of vitamin B12 can be decreased when used in combination with chloramphenicol.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "mianserin", "drug2": "felbamate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felbamate can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "ambenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ambenonium can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "Trometamol", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Trometamol.", "severity": 2}
{"drug1": "Amrinone", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Amrinone.", "severity": 2}
{"drug1": "Demecarium", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "olanzapine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Demecarium", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "etodolac", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "apomorphine", "drug2": "promazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of promazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "bromazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "PARAMETHADIONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PARAMETHADIONE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "formestane", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with formestane.", "severity": 2}
{"drug1": "suprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "indapamide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "donepezil", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Remikiren", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Remikiren can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Bethanidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bethanidine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "D-mannitol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of D-mannitol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "mifepristone", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BECLOMETHASONE DIPROPIONATE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "desipramine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with desipramine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "minocycline", "drug2": "dicloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicloxacillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Fluticasone furoate.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "salicylamide", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Vildagliptin.", "severity": 2}
{"drug1": "betahistine", "drug2": "dipivefrin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dipivefrin can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "clozapine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "Articaine", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "folic acid", "drug2": "Raltitrexed", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Raltitrexed can be decreased when used in combination with folic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "digitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of digitoxin can be decreased when used in combination with AMILORIDE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "hydroxyzine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroxyzine can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "ALENDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ALENDRONIC ACID can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "dicloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicloxacillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "physostigmine", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Aluminium hydroxide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with amcinonide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "leflunomide", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Dothiepin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Perospirone", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Perospirone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with flurandrenolide.", "severity": 2}
{"drug1": "memantine", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "etodolac", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "furosemide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "mestranol", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with VERAPAMIL.", "severity": 2}
{"drug1": "flumethasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with flumethasone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "carprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "physostigmine", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "azelastine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "physostigmine", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "medrysone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with medrysone.", "severity": 2}
{"drug1": "aspirin", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "donepezil", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Bivalirudin.", "severity": 2}
{"drug1": "mestranol", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Azelnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Azelnidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Benidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Benidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "cilnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilnidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with chlorprothixene.", "severity": 2}
{"drug1": "aminophylline", "drug2": "clonazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "resveratrol", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "Dienogest", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "mestranol", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Telithromycin.", "severity": 2}
{"drug1": "estriol", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with estriol.", "severity": 2}
{"drug1": "mifepristone", "drug2": "RIMEXOLONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of RIMEXOLONE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "penbutolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penbutolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "erythromycin", "drug2": "clindamycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clindamycin can be decreased when used in combination with erythromycin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with amcinonide.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "nimesulide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimesulide can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "donepezil", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ETHACRYNIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHACRYNIC ACID can be decreased when used in combination with methotrexate.", "severity": 2}
{"drug1": "goserelin", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with reserpine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with clotrimazole.", "severity": 2}
{"drug1": "apomorphine", "drug2": "mesoridazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesoridazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "memantine", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "memantine", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Tiludronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiludronic Acid can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "nifedipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nifedipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Cis-mdp", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Cis-mdp can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "donepezil", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "Droxicam", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "prednisone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with venlafaxine.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Salsalate", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "fludiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludiazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "memantine", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "mianserin", "drug2": "pergolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pergolide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Clevidipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "MOLINDONE", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with MOLINDONE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "cilnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilnidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "etodolac", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with oxymetazoline.", "severity": 2}
{"drug1": "physostigmine", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Halazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Halazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "imipramine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with imipramine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "paramethasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with paramethasone.", "severity": 2}
{"drug1": "progesterone", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "epinephrine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "rescinnamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rescinnamine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "memantine", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "lorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lorazepam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "suprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "benazepril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with benazepril.", "severity": 2}
{"drug1": "physostigmine", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "enalapril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of enalapril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "lorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lorazepam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Delorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Delorazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "mefloquine", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "azelastine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "haloprogin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with haloprogin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "METYROSINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of METYROSINE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "histrelin", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with nilvadipine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "manidipine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with manidipine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "flumethasone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flumethasone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "periciazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of periciazine can be decreased when used in combination with Rotigotine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "memantine", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with L-thyroxine.", "severity": 2}
{"drug1": "memantine", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "MOXONIDINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with MOXONIDINE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "nevirapine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with nevirapine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with DESONIDE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Blonanserin", "drug2": "Rotigotine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rotigotine can be decreased when used in combination with Blonanserin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "indapamide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "midodrine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with midodrine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with clomipramine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "mifepristone", "drug2": "PREDNICARBATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PREDNICARBATE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Darunavir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Dienogest", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "azelastine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with duloxetine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "theophylline", "drug2": "diazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "floctafenine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "dyphylline", "drug2": "estazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estazolam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "trazodone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trazodone can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "digitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of digitoxin can be decreased when used in combination with Eplerenone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "piperazine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "aspirin", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "memantine", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "histrelin", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "Apremilast", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "fenbufen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with trifluoperazine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "prednisone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "epinephrine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "linezolid", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with linezolid.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "Pimavanserin", "drug2": "ropinirole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ropinirole can be decreased when used in combination with Pimavanserin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "nimesulide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimesulide can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "doxylamine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with doxylamine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "nimesulide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "piperazine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "thiopental", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "piperazine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Dronedarone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "donepezil", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with oxiconazole.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with ELIGLUSTAT.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with mirtazapine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "tolfenamic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolfenamic acid can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "polymyxin b", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with polymyxin b.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with prochlorperazine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Eslicarbazepine acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "physostigmine", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mifepristone", "drug2": "loteprednol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of loteprednol can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "betahistine", "drug2": "Levalbuterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levalbuterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "chloroquine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "FLUOCORTOLONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of FLUOCORTOLONE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with bacampicillin.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "decamethonium", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "prednisone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "donepezil", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "Torasemide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "suprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "estrone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "flunarizine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with flunarizine.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ciprofloxacin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "carprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Voriconazole.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "VERAPAMIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VERAPAMIL can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "epirizole", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "epirizole", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "histrelin", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "salicylamide", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with RANOLAZINE.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "nimesulide", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "resveratrol", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "pergolide", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with pergolide.", "severity": 2}
{"drug1": "mifepristone", "drug2": "CLOCORTOLONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CLOCORTOLONE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Octreotide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "mianserin", "drug2": "ethotoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethotoin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "furosemide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Lormetazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lormetazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "suprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Demecarium", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "aspirin", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "clozapine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "pimozide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pimozide can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Halobetasol.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "apomorphine", "drug2": "periciazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of periciazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "doxepin", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with doxepin.", "severity": 2}
{"drug1": "naltrexone", "drug2": "ALFENTANIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ALFENTANIL can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Demecarium", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Flucloxacillin.", "severity": 2}
{"drug1": "mianserin", "drug2": "tiagabine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tiagabine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "doxycycline", "drug2": "penicillin g", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin g can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "decamethonium", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "ranitidine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with ranitidine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "mianserin", "drug2": "zonisamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of zonisamide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "mestranol", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifampicin.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "dyphylline", "drug2": "nitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "etodolac", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "diflunisal", "drug2": "probenecid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of probenecid can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "olanzapine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "progesterone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with fluocinonide.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "terbinafine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with terbinafine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "histrelin", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with efavirenz.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with SERTINDOLE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "methazolamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methazolamide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with VALPROIC ACID.", "severity": 2}
{"drug1": "dyphylline", "drug2": "adenosine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of adenosine can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "Icatibant", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "mifepristone", "drug2": "fludrocortisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludrocortisone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "testosterone propionate", "drug2": "Pipamperone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pipamperone can be decreased when used in combination with testosterone propionate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Etidronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Etidronic acid can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "theophylline", "drug2": "clorazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clorazepate can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "etodolac", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Thioproperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Thioproperazine can be decreased when used in combination with Rotigotine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "sulfamerazine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with sulfamerazine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "carprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "indapamide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "prednisone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "nimesulide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimesulide can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "theophylline", "drug2": "oxazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Fluticasone furoate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "epirizole", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "bumetanide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "prednisone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "estradiol", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "halcinonide", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with halcinonide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "digoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of digoxin can be decreased when used in combination with Eplerenone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with phenylephrine.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "ambenonium", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "ethionamide", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ethionamide.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "doxycycline", "drug2": "methicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methicillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "bacampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bacampicillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "TICARCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TICARCILLIN can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Tazobactam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tazobactam can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Pivmecillinam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Pivampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivampicillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "MOLINDONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOLINDONE can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "mestranol", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "betahistine", "drug2": "Salmeterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Salmeterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "colistin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with colistin.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "VERAPAMIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VERAPAMIL can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "progesterone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "leflunomide", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "donepezil", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "pyridoxine", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with pyridoxine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Dronedarone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with flumethasone.", "severity": 2}
{"drug1": "Naftifine", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "histrelin", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "MEZLOCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MEZLOCILLIN can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "promazine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with promazine.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with diethylstilbestrol.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with MELPERONE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Brivaracetam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "VERAPAMIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VERAPAMIL can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "diclofenac", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "celecoxib", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Demecarium", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pivmecillinam.", "severity": 2}
{"drug1": "Artemether", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Artemether.", "severity": 2}
{"drug1": "Asenapine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Midostaurin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with betaxolol.", "severity": 2}
{"drug1": "spironolactone", "drug2": "deslanoside", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of deslanoside can be decreased when used in combination with spironolactone.", "severity": 2}
{"drug1": "sertraline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with sertraline.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "piperacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of piperacillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Delavirdine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Mometasone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "malathion", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "ambenonium", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "carprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "estradiol", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "galanthamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of galanthamine can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Isoflurophate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Isoflurophate can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "aminophylline", "drug2": "fludiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludiazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefuroxime.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with flurandrenolide.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "tolmetin", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pivampicillin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "malathion", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with fluocinonide.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Fluprednidene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fluprednidene can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with fluvoxamine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "bacitracin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with bacitracin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with alclometasone.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with QUINESTROL.", "severity": 2}
{"drug1": "Thiosulfuric acid", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Thiosulfuric acid.", "severity": 2}
{"drug1": "diclofenac", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "mianserin", "drug2": "dihydroergotamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dihydroergotamine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "probenecid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of probenecid can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "memantine", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "ambenonium", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with cinnarizine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Clodronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clodronic Acid can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "goserelin", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Fosphenytoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "benazepril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benazepril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with flunisolide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "theophylline", "drug2": "bromazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with fenofibrate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Pranlukast", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pranlukast can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "decamethonium", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "lisinopril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lisinopril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with nefazodone.", "severity": 2}
{"drug1": "Buclizine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Buclizine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "betamethasone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betamethasone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "progesterone", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Apremilast", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Salbutamol.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "piperazine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with metaproterenol.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "naltrexone", "drug2": "DIPHENOXYLATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DIPHENOXYLATE can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifaximin.", "severity": 2}
{"drug1": "norethindrone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "budesonide", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with budesonide.", "severity": 2}
{"drug1": "Articaine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "PERHEXILINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERHEXILINE can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "naltrexone", "drug2": "DIHYDROCODEINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DIHYDROCODEINE can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "azelastine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Demecarium", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tazobactam.", "severity": 2}
{"drug1": "haloperidol", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with haloperidol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "mianserin", "drug2": "epinephrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epinephrine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "danazol", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "risperidone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "Mupirocin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mupirocin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with QUINESTROL.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Tapentadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tapentadol can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "epirizole", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "epirizole", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Droxicam", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "memantine", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "Articaine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "furosemide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "minocycline", "drug2": "Penicillin G benzathine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Penicillin G benzathine can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "minocycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "ethambutol", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ethambutol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with desoximetasone.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "amisulpride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amisulpride can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with clomipramine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "edrophonium", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "formestane", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with formestane.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "mianserin", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Levetiracetam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levetiracetam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "meropenem", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with meropenem.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "piperazine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "Milnacipran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Milnacipran can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "mestranol", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Azelnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Azelnidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Benidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Benidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "cilnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilnidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with Milnacipran.", "severity": 2}
{"drug1": "aminophylline", "drug2": "etizolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of etizolam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "TICARCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TICARCILLIN can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Pivmecillinam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Pivampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivampicillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Levomilnacipran.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "bacampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bacampicillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mesoridazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesoridazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "donepezil", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "naltrexone", "drug2": "propoxyphene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propoxyphene can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ethotoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethotoin can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with triflupromazine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "barnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of barnidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with ethopropazine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Gatate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gatate can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "danazol", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with AMILORIDE.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "theophylline", "drug2": "chlordiazepoxide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlordiazepoxide can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "dyphylline", "drug2": "clonazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "terbutaline", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with terbutaline.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Artemether", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Artemether.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "Droxicam", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "methazolamide", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with methazolamide.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "betahistine", "drug2": "norepinephrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norepinephrine can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Efonidipine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with clotrimazole.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with ticlopidine.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "ethanol", "drug2": "CYPROTERONE ACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYPROTERONE ACETATE can be decreased when used in combination with ethanol.", "severity": 2}
{"drug1": "betamethasone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with phenylephrine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "goserelin", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Tolcapone", "drug2": "Pipamperone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pipamperone can be decreased when used in combination with Tolcapone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "memantine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Posaconazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "estriol", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with estriol.", "severity": 2}
{"drug1": "estriol", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with estriol.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "dobutamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with dobutamine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "azlocillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of azlocillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "amoxicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amoxicillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "ofloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ofloxacin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Salsalate", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "furosemide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Dothiepin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "edrophonium", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "nimesulide", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Levocetirizine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "antipyrine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "edrophonium", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with DESONIDE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "cephaloridine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cephaloridine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "dienestrol", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with dienestrol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "CARTEOLOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CARTEOLOL can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "tizanidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tizanidine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "ALENDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ALENDRONIC ACID can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "quetiapine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Demecarium", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Demecarium", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with Aluminium hydroxide.", "severity": 2}
{"drug1": "cefpiramide", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefpiramide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "mefloquine", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "Dexbrompheniramine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Dexbrompheniramine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "progesterone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Camazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Camazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "dyphylline", "drug2": "midazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of midazolam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "cefmenoxime", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefmenoxime.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Metipranolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metipranolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "cefprozil", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefprozil.", "severity": 2}
{"drug1": "quetiapine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "naltrexone", "drug2": "DEZOCINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DEZOCINE can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with halcinonide.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "riluzole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of riluzole can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "naltrexone", "drug2": "butorphanol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of butorphanol can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "estradiol", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with flunisolide.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "ceftazidime", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ceftazidime can be decreased when used in combination with chloramphenicol.", "severity": 2}
{"drug1": "amobarbital", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "indinavir", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "indinavir", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with erythromycin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "Demecarium", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "minocycline", "drug2": "SULBACTAM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of SULBACTAM can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "rapamycin", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Caspofungin.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "lincomycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with lincomycin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "mianserin", "drug2": "nitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrazepam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with cinnarizine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with norepinephrine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "betamethasone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "memantine", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "ketorolac", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "butenafine", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with butenafine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "nicardipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nicardipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Butoconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Butoconazole.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "danazol", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "Etofibrate", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with Etofibrate.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "Darunavir", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "etodolac", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "tolfenamic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolfenamic acid can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "irbesartan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of irbesartan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "carprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Eslicarbazepine acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "CEFIXIME", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with CEFIXIME.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Articaine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "thiopental", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiopental can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with desoximetasone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "malathion", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "estrone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "mefloquine", "drug2": "OXCARBAZEPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of OXCARBAZEPINE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with tetracycline.", "severity": 2}
{"drug1": "donepezil", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "sulindac", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Fluprednidene.", "severity": 2}
{"drug1": "acemetacin", "drug2": "bumetanide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bumetanide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "oxazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "acemetacin", "drug2": "quinapril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinapril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Ceftobiprole", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftobiprole.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "galanthamine", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "fosinopril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with fosinopril.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with Eplerenone.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "ACETOPHENAZINE", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with ACETOPHENAZINE.", "severity": 2}
{"drug1": "ambenonium", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "DAPTOMYCIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with DAPTOMYCIN.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "probenecid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of probenecid can be decreased when used in combination with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "Salsalate", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with paramethasone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "nylidrin", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with nylidrin.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "clozapine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "risperidone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "tolmetin", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "chlordiazepoxide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlordiazepoxide can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Spirapril.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "epirizole", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "imipramine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with imipramine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "flurazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flurazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Articaine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with Escitalopram.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with clomipramine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Linagliptin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with MOEXIPRIL.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with hydroxyzine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Pinaverium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pinaverium can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "mianserin", "drug2": "norepinephrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norepinephrine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with ticlopidine.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "mestranol", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Salsalate", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "physostigmine", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "TRIPTORELIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIPTORELIN can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "epinephrine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "gentamicin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with gentamicin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "zonisamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of zonisamide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "tiagabine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tiagabine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Trometamol", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Trometamol.", "severity": 2}
{"drug1": "mesalamine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with RIMEXOLONE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "physostigmine", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "oxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxacillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "naltrexone", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "cinnarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cinnarizine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with MELPERONE.", "severity": 2}
{"drug1": "mianserin", "drug2": "GUANFACINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GUANFACINE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "tiagabine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tiagabine can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "zonisamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of zonisamide can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with flurandrenolide.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with difluprednate.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "decamethonium", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Pimavanserin", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Pimavanserin.", "severity": 2}
{"drug1": "theophylline", "drug2": "adenosine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of adenosine can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "acemetacin", "drug2": "hydralazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydralazine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Halobetasol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Halobetasol can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of FLUOCINOLONE ACETONIDE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with desoximetasone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "Raltitrexed", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Raltitrexed can be decreased when used in combination with Levoleucovorin.", "severity": 2}
{"drug1": "mianserin", "drug2": "carbamazepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carbamazepine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Ifenprodil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ifenprodil can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "zotepine", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with zotepine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with trimipramine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "mianserin", "drug2": "clorazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clorazepate can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "guanabenz", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of guanabenz can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "nifedipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nifedipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Ciclesonide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Fencamfamin", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Fencamfamin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "colchicine", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with colchicine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "cinnarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cinnarizine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "bumetanide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "penicillin v", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with penicillin v.", "severity": 2}
{"drug1": "mianserin", "drug2": "METHAMPHETAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of METHAMPHETAMINE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "thiopental", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiopental can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Clevidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "Pimavanserin", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with Pimavanserin.", "severity": 2}
{"drug1": "furosemide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "goserelin", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "goserelin", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "thiamylal", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "mestranol", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "furosemide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "promethazine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with promethazine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "alclofenac", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "etodolac", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "cerulenin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with cerulenin.", "severity": 2}
{"drug1": "bupropion", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with bupropion.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "carprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "potassium iodide", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with potassium iodide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "aspirin", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "donepezil", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "thiopental", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiopental can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "haloperidol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of haloperidol can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with amiodarone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "physostigmine", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "montelukast", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of montelukast can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "Anidulafungin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Anidulafungin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "indapamide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with difluprednate.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "phenobarbital", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenobarbital can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Quinine.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with DEFLAZACORT.", "severity": 2}
{"drug1": "resveratrol", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "thiamylal", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "Almasilate", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Almasilate.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Cis-mdp", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Cis-mdp can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "polythiazide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Tazobactam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tazobactam can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "thiopental", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Acitretin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "alclofenac", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "indapamide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "indapamide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "fenbufen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "loteprednol", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with loteprednol.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cloxacillin.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "didanosine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of didanosine can be decreased when used in combination with Tenofovir disoproxil.", "severity": 2}
{"drug1": "donepezil", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "chloroquine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "CYCLACILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYCLACILLIN can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "diazoxide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "budesonide", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with budesonide.", "severity": 2}
{"drug1": "citalopram", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with citalopram.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "epirizole", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Aluminium", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with Aluminium.", "severity": 2}
{"drug1": "furosemide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "betahistine", "drug2": "Arformoterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Arformoterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "dicloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicloxacillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "furosemide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "tolfenamic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolfenamic acid can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "clozapine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with alclometasone.", "severity": 2}
{"drug1": "Isothipendyl", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Isothipendyl.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "zaleplon", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of zaleplon can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "progesterone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "metolazone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "naltrexone", "drug2": "methadone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methadone can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "danazol", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "decamethonium", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "zaleplon", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of zaleplon can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Halobetasol.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Risedronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Risedronic acid can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "mesalamine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with RUCAPARIB.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Ibandronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ibandronic Acid can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "fenbufen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Zoledronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zoledronic acid can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "mestranol", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "azelastine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "chloroquine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Pinaverium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pinaverium can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "haloperidol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of haloperidol can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "malathion", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "cefoperazone", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefoperazone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "barnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of barnidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with paroxetine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "mianserin", "drug2": "acetazolamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetazolamide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "estradiol", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "fenbufen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "indapamide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pefloxacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Tixocortol.", "severity": 2}
{"drug1": "sulindac", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "epirizole", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with lithium ion.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "donepezil", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "levodopa", "drug2": "sulpiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of sulpiride can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "memantine", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with AMPHETAMINE.", "severity": 2}
{"drug1": "piperacillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with piperacillin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Amrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Amrinone can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Dienogest", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Cis-mdp", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Cis-mdp can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Darunavir", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "betahistine", "drug2": "droxidopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of droxidopa can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "suprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "L-methionine", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with L-methionine.", "severity": 2}
{"drug1": "minocycline", "drug2": "bacampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bacampicillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "minocycline", "drug2": "Pivmecillinam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "minocycline", "drug2": "Pivampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivampicillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "minocycline", "drug2": "TICARCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TICARCILLIN can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "ambenonium", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "thiopental", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with flumethasone.", "severity": 2}
{"drug1": "edrophonium", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Naftifine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "risperidone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "risperidone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Cis-mdp", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Cis-mdp can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "ritonavir", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "naltrexone", "drug2": "morphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of morphine can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "risperidone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "celecoxib", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "acemetacin", "drug2": "atenolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of atenolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Ibandronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ibandronic Acid can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "donepezil", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "halcinonide", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with halcinonide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "netilmicin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with netilmicin.", "severity": 2}
{"drug1": "theophylline", "drug2": "temazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of temazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "suprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "mifepristone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mifepristone can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "malathion", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "salicylamide", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "aspirin", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "aspirin", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "methimazole", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with methimazole.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "acemetacin", "drug2": "PAMABROM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PAMABROM can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "estrone", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "malathion", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Droxicam", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "azlocillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of azlocillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "amoxicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amoxicillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "estradiol", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with duloxetine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with reserpine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with hydroxyamphetamine.", "severity": 2}
{"drug1": "sulindac", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "indinavir", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Tiludronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiludronic Acid can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "mianserin", "drug2": "Brivaracetam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Brivaracetam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Delavirdine.", "severity": 2}
{"drug1": "Demecarium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "bepridil", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with bepridil.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Benidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Benidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Azelnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Azelnidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "cilnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilnidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Rolapitant.", "severity": 2}
{"drug1": "mefloquine", "drug2": "felbamate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felbamate can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Macitentan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Macitentan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Riociguat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Riociguat can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "etodolac", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with paroxetine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "memantine", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Salsalate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Blonanserin", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Blonanserin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "caffeine", "drug2": "adenosine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of adenosine can be decreased when used in combination with caffeine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "donepezil", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "felbamate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felbamate can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "theophylline", "drug2": "midazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of midazolam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "edrophonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of edrophonium can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "Acitretin", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "quinapril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with quinapril.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "progesterone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Thioproperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Thioproperazine can be decreased when used in combination with ropinirole.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "malathion", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "malathion", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Naftifine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "ENVIOMYCIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ENVIOMYCIN.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "trifluoperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trifluoperazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "cefoxitin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefoxitin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "CICLOPIROX", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with CICLOPIROX.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with Magaldrate.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Phensuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Phensuximide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Progabide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Progabide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "goserelin", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "goserelin", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "flunitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunitrazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "carbidopa", "drug2": "droxidopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of droxidopa can be decreased when used in combination with carbidopa.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "minocycline", "drug2": "oxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxacillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "Articaine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "citalopram", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with citalopram.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "furosemide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "PERHEXILINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERHEXILINE can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "epirizole", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "polythiazide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "prednisone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with bezafibrate.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "amikacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with amikacin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Lumefantrine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "olanzapine", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "fluvoxamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fluvoxamine can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "etizolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of etizolam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "memantine", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "midodrine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with midodrine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "malathion", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "estradiol", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Zoledronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zoledronic acid can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "doxycycline", "drug2": "nafcillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nafcillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Clobetasone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clobetasone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Demecarium", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "CYCLIZINE", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with CYCLIZINE.", "severity": 2}
{"drug1": "Salsalate", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Etidronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Etidronic acid can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Fluticasone furoate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "celecoxib", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "indomethacin", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "Demecarium", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "progesterone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "zotepine", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with zotepine.", "severity": 2}
{"drug1": "histrelin", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "ketorolac", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "Acitretin", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "histrelin", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with mesoridazine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Acitretin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with halcinonide.", "severity": 2}
{"drug1": "norethindrone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with RIMEXOLONE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "diazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "acemetacin", "drug2": "minoxidil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of minoxidil can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "aspirin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "STIRIPENTOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of STIRIPENTOL can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Tolvaptan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tolvaptan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "prednisone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "medrysone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of medrysone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "allopurinol", "drug2": "tegafur", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tegafur can be decreased when used in combination with allopurinol.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "venlafaxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of venlafaxine can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with loteprednol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "spironolactone", "drug2": "ouabain", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ouabain can be decreased when used in combination with spironolactone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "donepezil", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "norethindrone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with succinylcholine.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Alogliptin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with trimeprazine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "ALENDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ALENDRONIC ACID can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "quinidine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with quinidine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clorazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clorazepate can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Tixocortol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "memantine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of memantine can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "donepezil", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "malathion", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "mianserin", "drug2": "estazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estazolam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "etodolac", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "metolazone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with PREDNICARBATE.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "antipyrine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "indapamide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "gabapentin", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with gabapentin.", "severity": 2}
{"drug1": "sulindac", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with QUINESTROL.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "PERHEXILINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERHEXILINE can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "epirizole", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with RIMEXOLONE.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "piperazine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with acetazolamide.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "nimesulide", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "progesterone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "fenbufen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "NAFARELIN", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with NAFARELIN.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with VALPROIC ACID.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "cimetidine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with cimetidine.", "severity": 2}
{"drug1": "donepezil", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "decamethonium", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "edrophonium", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "doxycycline", "drug2": "ampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ampicillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "penicillin v", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin v can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "betahistine", "drug2": "terbutaline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of terbutaline can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with nortriptyline.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "mesalamine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with amcinonide.", "severity": 2}
{"drug1": "physostigmine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "amantadine", "drug2": "thiothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiothixene can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "amantadine", "drug2": "Thioproperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Thioproperazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "indinavir", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Halobetasol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with protriptyline.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "carprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with roxithromycin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "nizatidine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with nizatidine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "Articaine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with CYCLACILLIN.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "oxytetracycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with oxytetracycline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "mianserin", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PSEUDOEPHEDRINE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "etodolac", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "estradiol", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Ciclesonide.", "severity": 2}
{"drug1": "epirizole", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "meclizine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with meclizine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "nefazodone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nefazodone can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "equilin", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with equilin.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with VERAPAMIL.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with gemfibrozil.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "mestranol", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Articaine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with PREDNICARBATE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with isoniazid.", "severity": 2}
{"drug1": "mianserin", "drug2": "Delorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Delorazepam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "betahistine", "drug2": "Indacaterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Indacaterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "clozapine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with metaraminol.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Camazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Camazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "dyphylline", "drug2": "lorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lorazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "metolazone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "sulpiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of sulpiride can be decreased when used in combination with cabergoline.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "ambenonium", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "ceritinib", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Etidronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Etidronic acid can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "ritodrine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with ritodrine.", "severity": 2}
{"drug1": "danazol", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "capreomycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with capreomycin.", "severity": 2}
{"drug1": "danazol", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "memantine", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "norethindrone", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "etodolac", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "etodolac", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "piperazine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "progesterone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Levetiracetam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levetiracetam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "prednisone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Treprostinil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Treprostinil can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "acemetacin", "drug2": "timolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of timolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "fenoldopam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fenoldopam can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "acemetacin", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Apixaban.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "methicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methicillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "methyldopa", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with methyldopa.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "acemetacin", "drug2": "GUANETHIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GUANETHIDINE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "suprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Articaine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "mianserin", "drug2": "dipivefrin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dipivefrin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "nafcillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nafcillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gatifloxacin.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "ritonavir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "quinidine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with quinidine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Magaldrate.", "severity": 2}
{"drug1": "Latamoxef", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Latamoxef.", "severity": 2}
{"drug1": "memantine", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "piperazine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "risperidone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "piperazine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with MEPHENTERMINE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "salicylamide", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "minocycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with mirtazapine.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Pinaverium.", "severity": 2}
{"drug1": "mesalamine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "epirizole", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Articaine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Articaine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Asunaprevir.", "severity": 2}
{"drug1": "galanthamine", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "betahistine", "drug2": "PIRBUTEROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIRBUTEROL can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "mestranol", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "quetiapine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with fluvoxamine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "Dienogest", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "malathion", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "decamethonium", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "decamethonium", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with fluoxetine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "betamethasone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "isoniazid", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with isoniazid.", "severity": 2}
{"drug1": "epinephrine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "suprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "azelastine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "budesonide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of budesonide can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "metolazone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "indinavir", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with dorzolamide.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with xylometazoline.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Cis-mdp", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Cis-mdp can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "physostigmine", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "triamterene", "drug2": "ouabain", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ouabain can be decreased when used in combination with triamterene.", "severity": 2}
{"drug1": "histrelin", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "histrelin", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "Blonanserin", "drug2": "pramipexole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pramipexole can be decreased when used in combination with Blonanserin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "betamethasone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "cabergoline", "drug2": "amisulpride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amisulpride can be decreased when used in combination with cabergoline.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "mestranol", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Flupentixol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Flupentixol can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Echothiophate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Echothiophate can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "estriol", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with estriol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "fosinopril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fosinopril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "amobarbital", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with Magnesium trisilicate.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "antipyrine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "nimodipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with nimodipine.", "severity": 2}
{"drug1": "choline", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with choline.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "chloroquine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "Acitretin", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with metaproterenol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "malathion", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "suprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Amrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Amrinone can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "tranylcypromine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tranylcypromine can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "suprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "tolfenamic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolfenamic acid can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "L-glutamine", "drug2": "lactulose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lactulose can be decreased when used in combination with L-glutamine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "chlordiazepoxide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlordiazepoxide can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "primidone", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "aspirin", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "mesalamine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "betahistine", "drug2": "Vilanterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vilanterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "betahistine", "drug2": "OLODATEROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of OLODATEROL can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "alclofenac", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with isoproterenol.", "severity": 2}
{"drug1": "epinephrine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Mepyramine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Mepyramine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "etodolac", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "tolnaftate", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with tolnaftate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "cloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cloxacillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "memantine", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with duloxetine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "mianserin", "drug2": "ropinirole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ropinirole can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "nimesulide", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with protriptyline.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with dichlorphenamide.", "severity": 2}
{"drug1": "aspirin", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "Icatibant", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Tiludronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiludronic Acid can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "aminophylline", "drug2": "alprazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprazolam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "furosemide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "progesterone", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "mefloquine", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "tobramycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with tobramycin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "primidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of primidone can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with cyclosporin A.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "paroxetine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of paroxetine can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with GUANFACINE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Mephobarbital", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Mephobarbital can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Lercanidipine.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with diethylstilbestrol.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "kanamycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with kanamycin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Clobetasone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "tibolone", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "donepezil", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "pheniramine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with pheniramine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "azelastine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Ecabet", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Ecabet.", "severity": 2}
{"drug1": "suprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "tretinoin", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Bretylium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bretylium can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "Apremilast", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with FLUOCORTOLONE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "nifedipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nifedipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with loteprednol.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "malathion", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "tibolone", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Pinaverium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pinaverium can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "Cefditoren", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefditoren.", "severity": 2}
{"drug1": "malathion", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "suprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "aminophylline", "drug2": "quazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "prazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "DESMOPRESSIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESMOPRESSIN can be decreased when used in combination with Tolvaptan.", "severity": 2}
{"drug1": "memantine", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "streptomycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with streptomycin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "betahistine", "drug2": "metaproterenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metaproterenol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "nimesulide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimesulide can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "aminophylline", "drug2": "lorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lorazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "clozapine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "minocycline", "drug2": "ampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ampicillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "clonidine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with clonidine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "furosemide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "epirizole", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "thioridazine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with thioridazine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "epirizole", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with Dothiepin.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Retigabine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Retigabine can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Levomepromazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levomepromazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with pyrazinamide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "mestranol", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with flurandrenolide.", "severity": 2}
{"drug1": "methadone", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with methadone.", "severity": 2}
{"drug1": "methadone", "drug2": "abacavir", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of abacavir can be decreased when used in combination with methadone.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Ephedrine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "epinephrine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "Acitretin", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "amantadine", "drug2": "periciazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of periciazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "leflunomide", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "perphenazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of perphenazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "danazol", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Vitamin D3.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with venlafaxine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with cocaine.", "severity": 2}
{"drug1": "minocycline", "drug2": "MEZLOCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MEZLOCILLIN can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "malathion", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "sulindac", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "sulindac", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "BISOPROLOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BISOPROLOL can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "methotrexate", "drug2": "furosemide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of furosemide can be decreased when used in combination with methotrexate.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of HYDROXYPROGESTERONE CAPROATE can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "nizatidine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with nizatidine.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "ceritinib", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "cefaclor", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefaclor.", "severity": 2}
{"drug1": "zotepine", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with zotepine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "nifedipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nifedipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Ciclesonide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "cilnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilnidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Azelnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Azelnidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Benidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Benidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "galanthamine", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Mometasone.", "severity": 2}
{"drug1": "primidone", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with isoxsuprine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Flupentixol.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "decamethonium", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "cloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cloxacillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "carprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "mianserin", "drug2": "primidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of primidone can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "clozapine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "Quinagolide", "drug2": "sulpiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of sulpiride can be decreased when used in combination with Quinagolide.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "citalopram", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with citalopram.", "severity": 2}
{"drug1": "Dienogest", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "mianserin", "drug2": "Retigabine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Retigabine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "estrone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "amantadine", "drug2": "droperidol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of droperidol can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "nystatin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with nystatin.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "risperidone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "zotepine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with zotepine.", "severity": 2}
{"drug1": "pramipexole", "drug2": "sulpiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of sulpiride can be decreased when used in combination with pramipexole.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Magaldrate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "furosemide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "DESMOPRESSIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESMOPRESSIN can be decreased when used in combination with lithium ion.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "epirizole", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "resveratrol", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with fluoxetine.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Tedizolid phosphate", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tedizolid phosphate.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "donepezil", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with ELIGLUSTAT.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "NEOSTIGMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NEOSTIGMINE can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "chloroquine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "ampicillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ampicillin.", "severity": 2}
{"drug1": "estrone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Blonanserin", "drug2": "ropinirole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ropinirole can be decreased when used in combination with Blonanserin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "mestranol", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "theophylline", "drug2": "quazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "prazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "donepezil", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Brivaracetam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Brivaracetam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "carvedilol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carvedilol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "quetiapine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Remoxipride.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Lumefantrine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "galanthamine", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "estazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estazolam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Torasemide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Torasemide can be decreased when used in combination with methotrexate.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "norethindrone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norethindrone can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "malathion", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "mifepristone", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CLOBETASOL PROPIONATE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "alclometasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with alclometasone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "theophylline", "drug2": "lorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lorazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "spironolactone", "drug2": "acetyldigitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetyldigitoxin can be decreased when used in combination with spironolactone.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "Mometasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Mometasone.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "Demecarium", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "metoprolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metoprolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "suprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with amcinonide.", "severity": 2}
{"drug1": "sulindac", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Delorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Delorazepam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with paroxetine.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "Raltitrexed", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Raltitrexed can be decreased when used in combination with Levomefolic acid.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "chloroxine", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with chloroxine.", "severity": 2}
{"drug1": "progesterone", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "fluoxetine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fluoxetine can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with fluocinonide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with cyclobenzaprine.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with fenofibrate.", "severity": 2}
{"drug1": "mestranol", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Zuclopenthixol.", "severity": 2}
{"drug1": "estradiol", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "malathion", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "equilin", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with equilin.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "mianserin", "drug2": "Fosphenytoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "tripelennamine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with tripelennamine.", "severity": 2}
{"drug1": "sotalol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with sotalol.", "severity": 2}
{"drug1": "memantine", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Etidronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Etidronic acid can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "clozapine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "amisulpride", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with amisulpride.", "severity": 2}
{"drug1": "alclofenac", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with thioridazine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "nilvadipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nilvadipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "methadone", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with methadone.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "edrophonium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Naftifine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Quinupristin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Quinupristin.", "severity": 2}
{"drug1": "Salsalate", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "suprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "resveratrol", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "tibolone", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "Trometamol", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with Trometamol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "MIGLITOL", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with MIGLITOL.", "severity": 2}
{"drug1": "danazol", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "doxycycline", "drug2": "Flucloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "Demecarium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "oxprenolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxprenolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "FLUPHENAZINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of FLUPHENAZINE can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "nimesulide", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "ropinirole", "drug2": "periciazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of periciazine can be decreased when used in combination with ropinirole.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Demecarium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Demecarium can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "Blonanserin", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with Blonanserin.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "tolmetin", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "prazosin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prazosin can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Terlipressin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Terlipressin can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Fluprednidene.", "severity": 2}
{"drug1": "histrelin", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Magnesium trisilicate.", "severity": 2}
{"drug1": "aspirin", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "acemetacin", "drug2": "losartan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of losartan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Pimavanserin", "drug2": "Rotigotine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rotigotine can be decreased when used in combination with Pimavanserin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Octreotide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "levodopa", "drug2": "mesoridazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesoridazine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with TICARCILLIN.", "severity": 2}
{"drug1": "diclofenac", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Isoconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Isoconazole.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "acemetacin", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "famotidine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with famotidine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with halcinonide.", "severity": 2}
{"drug1": "estrone", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "floctafenine", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with nisoldipine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with paramethasone.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "minocycline", "drug2": "penicillin g", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin g can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "prednisone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "goserelin", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "doxycycline", "drug2": "MEZLOCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MEZLOCILLIN can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "dienestrol", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with dienestrol.", "severity": 2}
{"drug1": "dienestrol", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with dienestrol.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "bisacodyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bisacodyl can be decreased when used in combination with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with QUINESTROL.", "severity": 2}
{"drug1": "Etofibrate", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with Etofibrate.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Gatate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gatate can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Perospirone", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with Perospirone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "MOLINDONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOLINDONE can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "nitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "metolazone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "metolazone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Articaine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "minocycline", "drug2": "CYCLACILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYCLACILLIN can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "histrelin", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "PAMIDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PAMIDRONIC ACID can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "medrysone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with medrysone.", "severity": 2}
{"drug1": "fenbufen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "prednisone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "naltrexone", "drug2": "REMIFENTANIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of REMIFENTANIL can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "famotidine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with famotidine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "cefamandole", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefamandole.", "severity": 2}
{"drug1": "Demecarium", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "mianserin", "drug2": "phenobarbital", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenobarbital can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "danazol", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "fenbufen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "indomethacin", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "chlorprothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorprothixene can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "prednisone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "progesterone", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "galanthamine", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Delorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Delorazepam can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "etodolac", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "theophylline", "drug2": "estazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estazolam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "promazine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with promazine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "diazoxide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazoxide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "norethindrone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Cilastatin.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with DEFLAZACORT.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with CLOCORTOLONE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "acemetacin", "drug2": "alprenolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprenolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "promazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of promazine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "dorzolamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dorzolamide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "ketotifen", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with ketotifen.", "severity": 2}
{"drug1": "Apremilast", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "nabumetone", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "barnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of barnidipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "donepezil", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with DESONIDE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with Aluminium hydroxide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with droxidopa.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "sulindac", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "estriol", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with estriol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with FLUOCORTOLONE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with thalidomide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with loteprednol.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "levodopa", "drug2": "prochlorperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prochlorperazine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Zoledronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zoledronic acid can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Aliskiren", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aliskiren can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "dyphylline", "drug2": "flurazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flurazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "ropinirole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ropinirole can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Coenzyme Q10", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Coenzyme Q10 can be decreased when used in combination with propranolol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with DESONIDE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "loxapine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with loxapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "epirizole", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "progesterone", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "carprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "prednisone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "citalopram", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with citalopram.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with Tianeptine.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "naltrexone", "drug2": "HYDROCODONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of HYDROCODONE can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "risperidone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "azelastine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Cobicistat.", "severity": 2}
{"drug1": "theophylline", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "mestranol", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "physostigmine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "azelastine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "minocycline", "drug2": "piperacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of piperacillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Fluprednidene.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Mometasone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Mometasone can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "nabumetone", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with clenbuterol.", "severity": 2}
{"drug1": "histrelin", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with FLUPHENAZINE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Icatibant", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "malathion", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with VALPROIC ACID.", "severity": 2}
{"drug1": "acemetacin", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with loteprednol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with haloperidol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "diflunisal", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "carbamazepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carbamazepine can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "itraconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with itraconazole.", "severity": 2}
{"drug1": "Chloropyramine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Chloropyramine.", "severity": 2}
{"drug1": "malathion", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "memantine", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Ethylmorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ethylmorphine can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Vitamin D3.", "severity": 2}
{"drug1": "celecoxib", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "Demecarium", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Torasemide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "levodopa", "drug2": "periciazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of periciazine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "Salsalate", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "cilazapril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with cilazapril.", "severity": 2}
{"drug1": "decamethonium", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Salmeterol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "nifedipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nifedipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "norethindrone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Demecarium", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Lormetazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lormetazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "clozapine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with DEFLAZACORT.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "amobarbital", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "furosemide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with CEFPODOXIME.", "severity": 2}
{"drug1": "ambenonium", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "D-cycloserine", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with D-cycloserine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Propiverine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Propiverine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Pemirolast", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Pemirolast.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "diazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazepam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "amantadine", "drug2": "chlorprothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorprothixene can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Captodiame", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Captodiame can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "mefloquine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "ketorolac", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "diflunisal", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with venlafaxine.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "physostigmine", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "liothyronine", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with liothyronine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "mianserin", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "miconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with miconazole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "loxapine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of loxapine can be decreased when used in combination with bromocriptine.", "severity": 2}
{"drug1": "isoniazid", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with isoniazid.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with SERTINDOLE.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "diclofenac", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Articaine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "dyphylline", "drug2": "fludiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludiazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "physostigmine", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "clorazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clorazepate can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "5-Fluorocytosine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 5-Fluorocytosine can be decreased when used in combination with cytarabine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "vigabatrin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of vigabatrin can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "memantine", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "GUANADREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GUANADREL can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with thiothixene.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with MELPERONE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with SERTINDOLE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "primidone", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "NICORANDIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NICORANDIL can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "trimetrexate", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with trimetrexate.", "severity": 2}
{"drug1": "Octreotide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Remikiren.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "diflunisal", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "aminophylline", "drug2": "flurazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flurazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "suprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "suprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "ketorolac", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "thiopental", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "estrone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "memantine", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "mianserin", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "captopril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with captopril.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "estradiol", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "memantine", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with MEPHENTERMINE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "theophylline", "drug2": "triazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of triazolam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Clevidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clevidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "amantadine", "drug2": "FLUPHENAZINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of FLUPHENAZINE can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with fluoxetine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with ERGOTAMINE.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with Aluminium.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "ambenonium", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "estradiol", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "cocaine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with cocaine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "EDOXABAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDOXABAN can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "Flucloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "alclofenac", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "danazol", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "metolazone", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "physostigmine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of physostigmine can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "rivastigmine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rivastigmine can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "aspirin", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "mefloquine", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "acetazolamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetazolamide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with ropinirole.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Torasemide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Torasemide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with loteprednol.", "severity": 2}
{"drug1": "carprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Zoledronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zoledronic acid can be decreased when used in combination with omeprazole.", "severity": 2}
{"drug1": "prednisone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "chloroquine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "betahistine", "drug2": "formoterol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of formoterol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "histrelin", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "diflorasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with diflorasone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "NATAMYCIN", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with NATAMYCIN.", "severity": 2}
{"drug1": "indinavir", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "mefloquine", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "progesterone", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "fenbufen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with fenbufen.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "acemetacin", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Droxicam", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "sulindac", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "MELPERONE", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with MELPERONE.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "memantine", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "CYCLACILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYCLACILLIN can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "levodopa", "drug2": "FLUPHENAZINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of FLUPHENAZINE can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "thiothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiothixene can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "Thioproperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Thioproperazine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "levodopa", "drug2": "Zuclopenthixol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zuclopenthixol can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Desloratadine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "mianserin", "drug2": "OXCARBAZEPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of OXCARBAZEPINE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "malathion", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Ifenprodil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "estazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estazolam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Clodronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clodronic Acid can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "clotiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clotiazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "bromazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "epirizole", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Demecarium", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "floctafenine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Cyamemazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Cyamemazine.", "severity": 2}
{"drug1": "amantadine", "drug2": "prochlorperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prochlorperazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "nisoldipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nisoldipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "diltiazem", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diltiazem can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with SIMEPREVIR.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "Demecarium", "drug2": "trihexyphenidyl", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trihexyphenidyl can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Almasilate", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Almasilate.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Tigecycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tigecycline.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Clodronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clodronic Acid can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "imipenem", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with imipenem.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Roflumilast", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Roflumilast can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "Gatate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gatate can be decreased when used in combination with SOMATOSTATIN.", "severity": 2}
{"drug1": "metolazone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "estradiol", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "naltrexone", "drug2": "levorphanol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levorphanol can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Sitagliptin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "meprobamate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of meprobamate can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Naftifine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "medrysone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with medrysone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "tibolone", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "Demecarium", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "flunitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunitrazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "tofisopam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tofisopam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with clofibrate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "prednisone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "flutamide", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with flutamide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "theophylline", "drug2": "flurazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flurazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "norethindrone", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "formestane", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with formestane.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "reserpine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of reserpine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with Trometamol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Cinacalcet.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "Levetiracetam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levetiracetam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "primidone", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "sulfanilamide", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with sulfanilamide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Escitalopram.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "primidone", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "Dienogest", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "clozapine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "malathion", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "tolmetin", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ADINAZOLAM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ADINAZOLAM can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "malathion", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with amcinonide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "prednisone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "ketorolac", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "physostigmine", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Liotrix", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with Liotrix.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with QUINESTROL.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with QUINESTROL.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "epirizole", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Demecarium", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "etodolac", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with fluvoxamine.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Gestrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gestrinone can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "rapamycin", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "phenacemide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenacemide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "leflunomide", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Progabide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Progabide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Phensuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Phensuximide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Demecarium", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Salsalate", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "prednisone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "phenoxybenzamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenoxybenzamine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "acemetacin", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "donepezil", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "mianserin", "drug2": "naphazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of naphazoline can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "DESMOPRESSIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESMOPRESSIN can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with amitriptyline.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with PREDNICARBATE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Acitretin", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "MEGESTROL ACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MEGESTROL ACETATE can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "diazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Levomepromazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levomepromazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "barnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of barnidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "azelastine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Acitretin", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "PAMIDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PAMIDRONIC ACID can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "azelastine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "ketorolac", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "cefadroxil", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefadroxil.", "severity": 2}
{"drug1": "progesterone", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "risperidone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Dienogest", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "cilazapril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilazapril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "potassium ion", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of potassium ion can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "equilin", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with equilin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with diflorasone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Spirapril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Spirapril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "phentolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phentolamine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "estradiol", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "MOEXIPRIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOEXIPRIL can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Articaine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "sulindac", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "Acitretin", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with Milnacipran.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with duloxetine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "DESONIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESONIDE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "theophylline", "drug2": "etizolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of etizolam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "estrone", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "Dabigatran etexilate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "mianserin", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "indapamide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "indapamide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Ximelagatran.", "severity": 2}
{"drug1": "betahistine", "drug2": "epinephrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epinephrine can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "cefotiam", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefotiam.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "celiprolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of celiprolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Debrisoquine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Debrisoquine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "dimethyl sulfoxide", "drug2": "Dexrazoxane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dexrazoxane can be decreased when used in combination with dimethyl sulfoxide.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "ROLITETRACYCLINE", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ROLITETRACYCLINE.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with fluoxetine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "ambenonium", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "Articaine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "malathion", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "celecoxib", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Nabilone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Nabilone can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "mefloquine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mefloquine can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Dienogest", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "THYMOL", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with THYMOL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "epirizole", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "minocycline", "drug2": "azlocillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of azlocillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "minocycline", "drug2": "amoxicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amoxicillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "risperidone", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "prednisone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "progesterone", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "primidone", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Naftifine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "doxycycline", "drug2": "azlocillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of azlocillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "doxycycline", "drug2": "amoxicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amoxicillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "donepezil", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "donepezil", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "mianserin", "drug2": "brimonidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of brimonidine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "apomorphine", "drug2": "prochlorperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prochlorperazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with ETOFENAMATE.", "severity": 2}
{"drug1": "etodolac", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "acemetacin", "drug2": "labetalol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of labetalol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "AMILORIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of AMILORIDE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "doxazosin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of doxazosin can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "thiamylal", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "thiopental", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "quetiapine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "alclofenac", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "sulindac", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with oxyphenbutazone.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "naltrexone", "drug2": "pentazocine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentazocine can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "oxytetracycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with oxytetracycline.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with Magaldrate.", "severity": 2}
{"drug1": "levodopa", "drug2": "trifluoperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trifluoperazine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "fluconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with fluconazole.", "severity": 2}
{"drug1": "chloroquine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "nitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrazepam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "progesterone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of progesterone can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Cinacalcet.", "severity": 2}
{"drug1": "equilin", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with equilin.", "severity": 2}
{"drug1": "norethindrone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Risedronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Risedronic acid can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "norethindrone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Fluticasone furoate.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "Rivaroxaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "memantine", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "azelastine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "cefdinir", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefdinir.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with PREDNICARBATE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "nystatin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with nystatin.", "severity": 2}
{"drug1": "bumetanide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "bumetanide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Saxagliptin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "minocycline", "drug2": "penicillin v", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin v can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "piperazine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "estazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estazolam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "memantine", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "aspirin", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "piperazine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Mephobarbital", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Mephobarbital can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "epirizole", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "progesterone", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "physostigmine", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "triamterene", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with triamterene.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with ketoconazole.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "mestranol", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with flumethasone.", "severity": 2}
{"drug1": "carprofen", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Pimavanserin", "drug2": "apomorphine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of apomorphine can be decreased when used in combination with Pimavanserin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "amobarbital", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "resveratrol", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "mianserin", "drug2": "droxidopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of droxidopa can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "methocarbamol", "drug2": "pyridostigmine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pyridostigmine can be decreased when used in combination with methocarbamol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "azelastine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Apixaban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Apixaban can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "oxazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "mefloquine", "drug2": "topiramate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of topiramate can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "Octreotide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "suprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with benzphetamine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "acemetacin", "drug2": "ETHACRYNIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHACRYNIC ACID can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with phenobarbital.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "dienestrol", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with dienestrol.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "floctafenine", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "mianserin", "drug2": "Paliperidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Paliperidone can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "suprofen", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "suprofen", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Torasemide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "cefazolin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefazolin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with DESONIDE.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "VALPROIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VALPROIC ACID can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "citalopram", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with citalopram.", "severity": 2}
{"drug1": "betahistine", "drug2": "phenylpropanolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenylpropanolamine can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "mianserin", "drug2": "risperidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of risperidone can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "goserelin", "drug2": "11C-choline chloride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 11C-choline chloride can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "malathion", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "thiopental", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "progesterone", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "pentamidine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with CLOCORTOLONE.", "severity": 2}
{"drug1": "amantadine", "drug2": "amisulpride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amisulpride can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "Droxicam", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Articaine", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Nebivolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Nebivolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Potassium citrate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Potassium citrate can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "tretinoin", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "ramipril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with ramipril.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "bumetanide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "clozapine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with flumethasone.", "severity": 2}
{"drug1": "estrone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with haloperidol.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Ciclesonide.", "severity": 2}
{"drug1": "estradiol", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "piperazine", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with amprenavir.", "severity": 2}
{"drug1": "medrysone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with medrysone.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "polythiazide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "indinavir", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "ambenonium", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "rapamycin", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "acemetacin", "drug2": "pargyline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pargyline can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Ciclesonide.", "severity": 2}
{"drug1": "Icatibant", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "promazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with promazine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "doxycycline", "drug2": "oxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxacillin can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "gabapentin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gabapentin can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "acebutolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acebutolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "captopril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of captopril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Atomoxetine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "mianserin", "drug2": "oxymetazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxymetazoline can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "thiopental", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Sertaconazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Sertaconazole.", "severity": 2}
{"drug1": "aspirin", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "donepezil", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "etodolac", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "apomorphine", "drug2": "droperidol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of droperidol can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "goserelin", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "acemetacin", "drug2": "clonidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonidine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "diflunisal", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "acemetacin", "drug2": "propranolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propranolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "quazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "dyphylline", "drug2": "prazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of prazepam can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with spiramycin.", "severity": 2}
{"drug1": "mianserin", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "mianserin", "drug2": "xylometazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of xylometazoline can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "theophylline", "drug2": "fludiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludiazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "EFINACONAZOLE", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with EFINACONAZOLE.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "histrelin", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clonazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonazepam can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with fexofenadine.", "severity": 2}
{"drug1": "goserelin", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "tiapride", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with tiapride.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Lanreotide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "Articaine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "acemetacin", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "FOSFOMYCIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with FOSFOMYCIN.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "dydrogesterone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dydrogesterone can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "aspirin", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Darunavir", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "piperazine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "secobarbital", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Clevidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clevidipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "Darunavir", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "PHENPROCOUMON", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENPROCOUMON can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "indapamide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "memantine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "mianserin", "drug2": "tizanidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tizanidine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "ERGOTAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ERGOTAMINE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "dyphylline", "drug2": "flumazenil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flumazenil can be decreased when used in combination with dyphylline.", "severity": 2}
{"drug1": "suprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gemifloxacin.", "severity": 2}
{"drug1": "formestane", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with formestane.", "severity": 2}
{"drug1": "aspirin", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "nimesulide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimesulide can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "memantine", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with SULBACTAM.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with dicloxacillin.", "severity": 2}
{"drug1": "amantadine", "drug2": "Levomepromazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levomepromazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "acemetacin", "drug2": "BUPRANOLOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BUPRANOLOL can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "edrophonium", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with nitrendipine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "PERHEXILINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERHEXILINE can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "triamterene", "drug2": "deslanoside", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of deslanoside can be decreased when used in combination with triamterene.", "severity": 2}
{"drug1": "Perospirone", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Perospirone.", "severity": 2}
{"drug1": "donepezil", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "edrophonium", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Ambrisentan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ambrisentan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "edrophonium", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "mianserin", "drug2": "Rufinamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Rufinamide can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "Thioproperazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Thioproperazine can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "apomorphine", "drug2": "thiothixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of thiothixene can be decreased when used in combination with apomorphine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "amantadine", "drug2": "mesoridazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesoridazine can be decreased when used in combination with amantadine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "mestranol", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Clodronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clodronic Acid can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "haloperidol", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with haloperidol.", "severity": 2}
{"drug1": "etodolac", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "mefloquine", "drug2": "phenytoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenytoin can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "dopamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with dopamine.", "severity": 2}
{"drug1": "Acitretin", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "nabumetone", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "acemetacin", "drug2": "methyldopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyldopa can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "histrelin", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Telmisartan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Telmisartan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "Acitretin", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "alclofenac", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "antazoline", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with antazoline.", "severity": 2}
{"drug1": "desipramine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with desipramine.", "severity": 2}
{"drug1": "piperazine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "methacycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with methacycline.", "severity": 2}
{"drug1": "Telavancin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Telavancin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "goserelin", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "doxepin", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with doxepin.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "floctafenine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "sulindac", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "emedastine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with emedastine.", "severity": 2}
{"drug1": "budesonide", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with budesonide.", "severity": 2}
{"drug1": "droperidol", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with droperidol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "clozapine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "clozapine", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ethinyl estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethinyl estradiol can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "aspirin", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with alclometasone.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "galanthamine", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with diphenhydramine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "metolazone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Flucloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "epirizole", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "Gestrinone", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with Gestrinone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "difluprednate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of difluprednate can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "halcinonide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of halcinonide can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "Perospirone", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with Perospirone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "carprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with Magnesium trisilicate.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "aspirin", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with aspirin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Halobetasol.", "severity": 2}
{"drug1": "clozapine", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with clozapine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "pentosan polysulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pentosan polysulfate can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "cinnarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cinnarizine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "DIMETHINDENE", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with DIMETHINDENE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "Darunavir", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with tolfenamic acid.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "clorazepate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clorazepate can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with QUINETHAZONE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "antipyrine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Lumefantrine.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "enalapril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with enalapril.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "mianserin", "drug2": "VALPROIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of VALPROIC ACID can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "decamethonium", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "cetirizine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with cetirizine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with Trometamol.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with diethylstilbestrol.", "severity": 2}
{"drug1": "ambenonium", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Icatibant", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "sulindac", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "alclofenac", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "secobarbital", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "norgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norgestrel can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "progesterone", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Bosentan", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bosentan can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "floctafenine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "theophylline", "drug2": "flunitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunitrazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Amrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Amrinone can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Vorinostat", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Vorinostat.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Icatibant", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with ZILEUTON.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Icatibant", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "edrophonium", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with diethylstilbestrol.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "edrophonium", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "prednisone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with desoximetasone.", "severity": 2}
{"drug1": "decamethonium", "drug2": "methscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methscopolamine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "PAMIDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PAMIDRONIC ACID can be decreased when used in combination with dexlansoprazole.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "Naftifine", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Mometasone.", "severity": 2}
{"drug1": "levodopa", "drug2": "Flupentixol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Flupentixol can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Halobetasol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "progesterone", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Fluticasone furoate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fluticasone furoate can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "PERHEXILINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERHEXILINE can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "MEGESTROL ACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MEGESTROL ACETATE can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Thioproperazine.", "severity": 2}
{"drug1": "Fenofibric acid", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with Fenofibric acid.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "levodopa", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of levodopa can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with PIRBUTEROL.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with Aluminium hydroxide.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "dicyclomine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicyclomine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "tropicamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tropicamide can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "mesalamine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "goserelin", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with secobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "Salsalate", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "oxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxacillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with lomefloxacin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "nabumetone", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with pantoprazole.", "severity": 2}
{"drug1": "Phenindamine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with Phenindamine.", "severity": 2}
{"drug1": "malathion", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with ibuprofen.", "severity": 2}
{"drug1": "diflunisal", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "Cefacetrile", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefacetrile.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "ketorolac", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "danazol", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "mianserin", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "histrelin", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "equilin", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with equilin.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "metolazone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "benztropine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benztropine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "tubocurarine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tubocurarine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "mefloquine", "drug2": "PARALDEHYDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PARALDEHYDE can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "STIRIPENTOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of STIRIPENTOL can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with PERINDOPRIL.", "severity": 2}
{"drug1": "furosemide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "furosemide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "histrelin", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "epirizole", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "polythiazide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "metolazone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with metolazone.", "severity": 2}
{"drug1": "furosemide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with furosemide.", "severity": 2}
{"drug1": "estradiol", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "isradipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isradipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with fluoxetine.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "estradiol", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "Demecarium", "drug2": "Fesoterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fesoterodine can be decreased when used in combination with Demecarium.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "danazol", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with cimetidine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "olanzapine", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "benztropine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with benztropine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "progesterone", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "sertraline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of sertraline can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "progesterone", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "theophylline", "drug2": "Camazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Camazepam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "barnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of barnidipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "physostigmine", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "topiramate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of topiramate can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "physostigmine", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "acemetacin", "drug2": "GUANFACINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GUANFACINE can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with cilnidipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with hydroflumethiazide.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "MEZLOCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MEZLOCILLIN can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "citalopram", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citalopram can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Acitretin", "drug2": "Estrone sulfate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Acitretin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with Clobetasone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with nortriptyline.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "donepezil", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with donepezil.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Lacidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lacidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "cilnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilnidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Benidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Benidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Clobetasone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with acebutolol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "edrophonium", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Lercanidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "mifepristone", "drug2": "flurandrenolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flurandrenolide can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "sulindac", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "phenytoin", "drug2": "NORGESTIMATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of NORGESTIMATE can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "amantadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amantadine can be decreased when used in combination with SERTINDOLE.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with RUCAPARIB.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "celecoxib", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "primidone", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with primidone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "Octreotide", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Octreotide.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "quinidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of quinidine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with ceritinib.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "diazoxide", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "diazoxide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "estrone", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "diazoxide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with diazoxide.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with penicillin g.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "sulindac", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "indomethacin", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "tretinoin", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ethosuximide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethosuximide can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "nitrazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "penicillin g", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin g can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "formestane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of formestane can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Normethadone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Normethadone can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with flunisolide.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "danazol", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with actinomycin D.", "severity": 2}
{"drug1": "betahistine", "drug2": "isoetharine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of isoetharine can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "donepezil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of donepezil can be decreased when used in combination with dipyridamole.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with methyclothiazide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "vigabatrin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of vigabatrin can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Clevidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "nimesulide", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Amrinone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Amrinone can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with PIRFENIDONE.", "severity": 2}
{"drug1": "Apremilast", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "rapamycin", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "mefloquine", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "physostigmine", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "physostigmine", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with METHAMPHETAMINE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Atazanavir.", "severity": 2}
{"drug1": "Oxetacaine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Oxetacaine.", "severity": 2}
{"drug1": "piperazine", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "CYPROHEPTADINE", "drug2": "fluvoxamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fluvoxamine can be decreased when used in combination with CYPROHEPTADINE.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "doxycycline", "drug2": "CYCLACILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYCLACILLIN can be decreased when used in combination with doxycycline.", "severity": 2}
{"drug1": "decamethonium", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "diflunisal", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "celecoxib", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "mifepristone", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "levodopa", "drug2": "perphenazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of perphenazine can be decreased when used in combination with levodopa.", "severity": 2}
{"drug1": "pimozide", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with pimozide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with epinephrine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "Apremilast", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Apremilast.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with pentobarbital.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "Pimavanserin", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with Pimavanserin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "3,4-Dihydroxybenzaldehyde", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 3,4-Dihydroxybenzaldehyde can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "memantine", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "ceftizoxime", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ceftizoxime.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Clevidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "prednisone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with perphenazine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with hydrocortisone.", "severity": 2}
{"drug1": "DALFOPRISTIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with DALFOPRISTIN.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "ampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ampicillin can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "demeclocycline", "drug2": "penicillin v", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of penicillin v can be decreased when used in combination with demeclocycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "prednisone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "indinavir", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "danazol", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "mianserin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Finafloxacin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Finafloxacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "MEDROGESTONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MEDROGESTONE can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "betahistine", "drug2": "celiprolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of celiprolol can be decreased when used in combination with betahistine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Risedronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Risedronic acid can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with VANCOMYCIN.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with diclofenac.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "GESTODENE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GESTODENE can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "orphenadrine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of orphenadrine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "epirizole", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with epirizole.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with levonordefrin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with niflumic acid.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "tretinoin", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Pentolinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pentolinium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "edrophonium", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "malathion", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Mirabegron.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "cefotaxime", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefotaxime.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "mestranol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mestranol can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "ambenonium", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Risedronic acid.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Aceclofenac.", "severity": 2}
{"drug1": "indomethacin", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "thiopental", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "sulpiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of sulpiride can be decreased when used in combination with ropinirole.", "severity": 2}
{"drug1": "estradiol", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "azelastine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "josamycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with josamycin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Midostaurin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "deslanoside", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of deslanoside can be decreased when used in combination with Eplerenone.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "tolterodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolterodine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Metixene", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Metixene can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "edrophonium", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with edrophonium.", "severity": 2}
{"drug1": "indapamide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "Naftifine", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Benidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Benidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "quetiapine", "drug2": "bromocriptine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromocriptine can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "carprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Carbimazole", "drug2": "Radioiodine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Radioiodine can be decreased when used in combination with Carbimazole.", "severity": 2}
{"drug1": "estradiol", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Aclidinium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Aclidinium can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MAGNESIUM SULFATE can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "thiopental", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with Coenzyme Q10.", "severity": 2}
{"drug1": "mefloquine", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Rolapitant.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Liotrix", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Liotrix can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with triamcinolone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "scopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of scopolamine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "riluzole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of riluzole can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Clevidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clevidipine can be decreased when used in combination with Glubionate calcium.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "tolfenamic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolfenamic acid can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "goserelin", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "norethindrone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norethindrone can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "mestranol", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with mestranol.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "danazol", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "spironolactone", "drug2": "digitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of digitoxin can be decreased when used in combination with spironolactone.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "mifepristone", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "dienestrol", "drug2": "anastrozole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of anastrozole can be decreased when used in combination with dienestrol.", "severity": 2}
{"drug1": "theophylline", "drug2": "alprazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprazolam can be decreased when used in combination with theophylline.", "severity": 2}
{"drug1": "sulindac", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "indapamide", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "nabumetone", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with nabumetone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "ritonavir", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "norfloxacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of norfloxacin can be decreased when used in combination with nitrofurantoin.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with ADAPALENE.", "severity": 2}
{"drug1": "Articaine", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Articaine.", "severity": 2}
{"drug1": "Artemether", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Artemether.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with NAPROXEN.", "severity": 2}
{"drug1": "Aluminium", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Aluminium.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Pregabalin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pregabalin can be decreased when used in combination with calcium lactate.", "severity": 2}
{"drug1": "memantine", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Bambuterol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "bumetanide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bumetanide can be decreased when used in combination with methotrexate.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with ethinyl estradiol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with AMPHETAMINE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Pinaverium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pinaverium can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Desloratadine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Desloratadine can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "AZATADINE", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with AZATADINE.", "severity": 2}
{"drug1": "suprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with salicylic acid.", "severity": 2}
{"drug1": "indapamide", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Tipiracil.", "severity": 2}
{"drug1": "medrysone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with medrysone.", "severity": 2}
{"drug1": "salicylamide", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "salicylamide", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "alprazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprazolam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with nicardipine.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "celecoxib", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with celecoxib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with chlorothiazide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "flunarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunarizine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "bromazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bromazepam can be decreased when used in combination with aminophylline.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "ACENOCOUMAROL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ACENOCOUMAROL can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Tiotropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tiotropium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Dabrafenib.", "severity": 2}
{"drug1": "leflunomide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with leflunomide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "astemizole", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with astemizole.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Quinagolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Quinagolide can be decreased when used in combination with Ziprasidone.", "severity": 2}
{"drug1": "Salsalate", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "propantheline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of propantheline can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "dienestrol", "drug2": "EXEMESTANE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EXEMESTANE can be decreased when used in combination with dienestrol.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Drospirenone.", "severity": 2}
{"drug1": "ketorolac", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "ketorolac", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with ketorolac.", "severity": 2}
{"drug1": "AMILORIDE", "drug2": "acetyldigitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetyldigitoxin can be decreased when used in combination with AMILORIDE.", "severity": 2}
{"drug1": "histrelin", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with histrelin.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Masoprocol.", "severity": 2}
{"drug1": "argatroban", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with argatroban.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "labetalol", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with labetalol.", "severity": 2}
{"drug1": "difluprednate", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with difluprednate.", "severity": 2}
{"drug1": "bifonazole", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with bifonazole.", "severity": 2}
{"drug1": "indomethacin", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "tolmetin", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Lumiracoxib.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with fenoprofen.", "severity": 2}
{"drug1": "acemetacin", "drug2": "trandolapril", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trandolapril can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with dipivefrin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "alclofenac", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with alclofenac.", "severity": 2}
{"drug1": "prednisone", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "prednisone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cephalexin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "desipramine", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with desipramine.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with fludrocortisone.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "resveratrol", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with celiprolol.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Clodronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Clodronic Acid can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "goserelin", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "pirenzepine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pirenzepine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "bumetanide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "risperidone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with ropinirole.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "etodolac", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with etodolac.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with rivastigmine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "amiodarone", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with amiodarone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "PERHEXILINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERHEXILINE can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "acemetacin", "drug2": "nadolol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nadolol can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "citric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of citric acid can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "olanzapine", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Aripiprazole.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with Milnacipran.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with thiamylal.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "tolfenamic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolfenamic acid can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "Droxicam", "drug2": "alprostadil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of alprostadil can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "ethotoin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethotoin can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Droxicam", "drug2": "hydroflumethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydroflumethiazide can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "phenindione", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of phenindione can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "clopidogrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clopidogrel can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "malathion", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "acemetacin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acemetacin can be decreased when used in combination with norepinephrine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "malathion", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "progesterone", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "voglibose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of voglibose can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "mianserin", "drug2": "DEXMEDETOMIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DEXMEDETOMIDINE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with olanzapine.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "risperidone", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "lisinopril", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with lisinopril.", "severity": 2}
{"drug1": "cefmetazole", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with cefmetazole.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "argatroban", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of argatroban can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "mianserin", "drug2": "lorazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of lorazepam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Torasemide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Ibandronic Acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ibandronic Acid can be decreased when used in combination with Esomeprazole.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Teriflunomide.", "severity": 2}
{"drug1": "tibolone", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with tibolone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Trospium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Trospium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "sulindac", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with sulindac.", "severity": 2}
{"drug1": "phenytoin", "drug2": "estramustine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estramustine can be decreased when used in combination with phenytoin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with SERATRODAST.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ANISOTROPINE METHYLBROMIDE can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Pasireotide.", "severity": 2}
{"drug1": "malathion", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "PHENYLACETIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PHENYLACETIC ACID can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "equilin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of equilin can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with diflorasone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "malathion", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "malathion", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Salsalate", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Dienogest", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with Dienogest.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "diflunisal", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with diflunisal.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Glycopyrronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Avibactam", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Avibactam.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "indapamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of indapamide can be decreased when used in combination with Nepafenac.", "severity": 2}
{"drug1": "malathion", "drug2": "Atracurium besylate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Atracurium besylate can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "L-thyroxine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of L-thyroxine can be decreased when used in combination with Levomilnacipran.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Pioglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Pipotiazine.", "severity": 2}
{"drug1": "risperidone", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with risperidone.", "severity": 2}
{"drug1": "azelastine", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Tixocortol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "dicumarol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dicumarol can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "estradiol", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with estradiol.", "severity": 2}
{"drug1": "prednisone", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with prednisone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "Vecuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vecuronium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ouabain", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ouabain can be decreased when used in combination with Eplerenone.", "severity": 2}
{"drug1": "Echothiophate", "drug2": "pancuronium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pancuronium can be decreased when used in combination with Echothiophate.", "severity": 2}
{"drug1": "Droxicam", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "dydrogesterone", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with dydrogesterone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "decamethonium", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with decamethonium.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "cinnarizine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cinnarizine can be decreased when used in combination with Calcium acetate.", "severity": 2}
{"drug1": "acemetacin", "drug2": "nitrendipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nitrendipine can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "memantine", "drug2": "PIPECURONIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PIPECURONIUM can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "estrone", "drug2": "chenodeoxycholic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chenodeoxycholic acid can be decreased when used in combination with estrone.", "severity": 2}
{"drug1": "TRIPTORELIN", "drug2": "glimepiride", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glimepiride can be decreased when used in combination with TRIPTORELIN.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with Torasemide.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with CLONIXIN.", "severity": 2}
{"drug1": "carprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with Lorcaserin.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with nicotinic acid.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with nelfinavir.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETHYNODIOL DIACETATE can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "DESOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of DESOGESTREL can be decreased when used in combination with METHOHEXITAL.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "gliclazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gliclazide can be decreased when used in combination with Lurasidone.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "warfarin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of warfarin can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "MOXONIDINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MOXONIDINE can be decreased when used in combination with amitriptyline.", "severity": 2}
{"drug1": "physostigmine", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with physostigmine.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with tenoxicam.", "severity": 2}
{"drug1": "tolmetin", "drug2": "Tafluprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tafluprost can be decreased when used in combination with tolmetin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BECLOMETHASONE DIPROPIONATE can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "goserelin", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with goserelin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Pimecrolimus.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "halcinonide", "drug2": "benzoic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of benzoic acid can be decreased when used in combination with halcinonide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "epoprostenol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of epoprostenol can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Naftifine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dienestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dienestrol can be decreased when used in combination with carbamazepine.", "severity": 2}
{"drug1": "Naftifine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Isotretinoin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Isotretinoin.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "ursodiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ursodiol can be decreased when used in combination with gemfibrozil.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "nizatidine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with nizatidine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with CORTISONE ACETATE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with paroxetine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Vildagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Vildagliptin can be decreased when used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "folic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of folic acid can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Olopatadine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "thiopental", "drug2": "Dienogest", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Dienogest can be decreased when used in combination with thiopental.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "suprofen", "drug2": "trichlormethiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of trichlormethiazide can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "paramethasone", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with paramethasone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with RIFAPENTINE.", "severity": 2}
{"drug1": "clemastine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with clemastine.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "bepridil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bepridil can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with Mometasone.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with clenbuterol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with rapamycin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Pinaverium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pinaverium can be decreased when used in combination with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "azelastine", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with azelastine.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "methenamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methenamine can be decreased when used in combination with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "flunisolide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of flunisolide can be decreased when used in combination with amoxapine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "ALENDRONIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ALENDRONIC ACID can be decreased when used in combination with lansoprazole.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "pramipexole", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of pramipexole can be decreased when used in combination with Cariprazine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with pentamidine.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with NORGESTIMATE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with ritonavir.", "severity": 2}
{"drug1": "Droxicam", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Tramadol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tramadol can be decreased when used in combination with nicardipine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "midazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of midazolam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with Aluminium hydroxide.", "severity": 2}
{"drug1": "indinavir", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with indinavir.", "severity": 2}
{"drug1": "malathion", "drug2": "oxyphenonium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxyphenonium can be decreased when used in combination with malathion.", "severity": 2}
{"drug1": "paromomycin", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with paromomycin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "triamterene", "drug2": "acetyldigitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acetyldigitoxin can be decreased when used in combination with triamterene.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with Calcium phosphate.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with indomethacin.", "severity": 2}
{"drug1": "bumetanide", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with bumetanide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Corticorelin ovine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Corticorelin ovine can be decreased when used in combination with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with oxaprozin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Camazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Camazepam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "EDTA", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of EDTA can be decreased when used in combination with allylestrenol.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with ETONOGESTREL.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with BENZYDAMINE.", "severity": 2}
{"drug1": "indapamide", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with indapamide.", "severity": 2}
{"drug1": "mianserin", "drug2": "meprobamate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of meprobamate can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Tigecycline", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENICILLIN G PROCAINE can be decreased when used in combination with Tigecycline.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "metformin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metformin can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "piperazine", "drug2": "Repaglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Repaglinide can be decreased when used in combination with piperazine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "triazolam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of triazolam can be decreased when used in combination with Yohimbine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Levomepromazine.", "severity": 2}
{"drug1": "salicylamide", "drug2": "gemeprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of gemeprost can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "MEDROGESTONE", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with MEDROGESTONE.", "severity": 2}
{"drug1": "mefloquine", "drug2": "cyclopentolate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cyclopentolate can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "ambenonium", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GALLAMINE TRIETHIODIDE can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Nilotinib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Zoledronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Zoledronic acid can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "betamethasone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "carprofen", "drug2": "methyclothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methyclothiazide can be decreased when used in combination with carprofen.", "severity": 2}
{"drug1": "ambenonium", "drug2": "Butylscopolamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Butylscopolamine can be decreased when used in combination with ambenonium.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "naltrexone", "drug2": "hydromorphone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydromorphone can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Tixocortol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tixocortol can be decreased when used in combination with mifepristone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "stavudine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of stavudine can be decreased when used in combination with doxorubicin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with polythiazide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Asenapine.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "misoprostol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of misoprostol can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Propacetamol", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with Propacetamol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Levonorgestrel.", "severity": 2}
{"drug1": "nimesulide", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with nimesulide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with chloroquine.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "procyclidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of procyclidine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "triamterene", "drug2": "digitoxin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of digitoxin can be decreased when used in combination with triamterene.", "severity": 2}
{"drug1": "cimetidine", "drug2": "betahistine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of betahistine can be decreased when used in combination with cimetidine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with phenylpropanolamine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ethopropazine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ethopropazine can be decreased when used in combination with mefloquine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "ETONOGESTREL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ETONOGESTREL can be decreased when used in combination with Ulipristal.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "mecamylamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mecamylamine can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with ketoprofen.", "severity": 2}
{"drug1": "Salsalate", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with Salsalate.", "severity": 2}
{"drug1": "Naftifine", "drug2": "amphotericin b", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of amphotericin b can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "eperisone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of eperisone can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Saxagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Saxagliptin can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "progesterone", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with progesterone.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "Latanoprostene BUNOD", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Latanoprostene BUNOD can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Prostaglandin E2", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Prostaglandin E2 can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "estriol", "drug2": "liothyronine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of liothyronine can be decreased when used in combination with estriol.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "polythiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of polythiazide can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with tiaprofenic acid.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "hyoscyamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hyoscyamine can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "resveratrol", "drug2": "QUINETHAZONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of QUINETHAZONE can be decreased when used in combination with resveratrol.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Naftifine", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Naftifine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "glyburide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glyburide can be decreased when used in combination with quetiapine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "nimodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nimodipine can be decreased when used in combination with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "acemetacin", "drug2": "PERINDOPRIL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PERINDOPRIL can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "tolazoline", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazoline can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "acemetacin", "drug2": "Candesartan cilexetil", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Candesartan cilexetil can be decreased when used in combination with acemetacin.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with meclofenamic acid.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Efonidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Efonidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with Hexobarbital.", "severity": 2}
{"drug1": "floctafenine", "drug2": "latanoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of latanoprost can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Azelnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Azelnidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "cilnidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cilnidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "chlorthalidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorthalidone can be decreased when used in combination with Lornoxicam.", "severity": 2}
{"drug1": "Nomegestrol", "drug2": "Fondaparinux", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Fondaparinux can be decreased when used in combination with Nomegestrol.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "manidipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of manidipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with zaltoprofen.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Etoricoxib.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "estradiol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of estradiol can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "OXCARBAZEPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of OXCARBAZEPINE can be decreased when used in combination with Pregabalin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Etidronic acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Etidronic acid can be decreased when used in combination with rabeprazole.", "severity": 2}
{"drug1": "mianserin", "drug2": "clonidine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clonidine can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "dinoprost tromethamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dinoprost tromethamine can be decreased when used in combination with sulfasalazine.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Loxoprofen.", "severity": 2}
{"drug1": "Vapreotide", "drug2": "Gatate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gatate can be decreased when used in combination with Vapreotide.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Linagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Linagliptin can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with tacrolimus.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with trichlormethiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Miglustat", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Miglustat can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with methylprednisolone.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "TRIMETHAPHAN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TRIMETHAPHAN can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "mianserin", "drug2": "PARAMETHADIONE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PARAMETHADIONE can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "diethylstilbestrol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of diethylstilbestrol can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "spironolactone", "drug2": "mitotane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mitotane can be decreased when used in combination with spironolactone.", "severity": 2}
{"drug1": "mesalamine", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "suprofen", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with suprofen.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with mycophenolic acid.", "severity": 2}
{"drug1": "Droxicam", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with Droxicam.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with Fluprednidene.", "severity": 2}
{"drug1": "danazol", "drug2": "Canagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Canagliflozin can be decreased when used in combination with danazol.", "severity": 2}
{"drug1": "salicylamide", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with salicylamide.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "felodipine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of felodipine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "glipizide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of glipizide can be decreased when used in combination with chlorthalidone.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Gliquidone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Gliquidone can be decreased when used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "Travoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Travoprost can be decreased when used in combination with BALSALAZIDE.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "Iobenguane", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Iobenguane can be decreased when used in combination with xylometazoline.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with arsenic trioxide.", "severity": 2}
{"drug1": "memantine", "drug2": "oxybutynin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxybutynin can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "MIGLITOL", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of MIGLITOL can be decreased when used in combination with Darunavir.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with Lopinavir.", "severity": 2}
{"drug1": "cimetidine", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with cimetidine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of GLYCEROL PHENYLBUTYRATE can be decreased when used in combination with CLOCORTOLONE.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Alogliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Alogliptin can be decreased when used in combination with hydrochlorothiazide.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "Bimatoprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bimatoprost can be decreased when used in combination with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "dapsone", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with dapsone.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bismuth subcitrate potassium can be decreased when used in combination with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "ATROPINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ATROPINE can be decreased when used in combination with pyridostigmine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "calcitriol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of calcitriol can be decreased when used in combination with betamethasone.", "severity": 2}
{"drug1": "mianserin", "drug2": "fludiazepam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of fludiazepam can be decreased when used in combination with mianserin.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Drospirenone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Drospirenone can be decreased when used in combination with tretinoin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with dexamethasone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Estrone sulfate.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "Lubiprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Olsalazine.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Ximelagatran", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Ximelagatran can be decreased when used in combination with norethindrone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "rosiglitazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of rosiglitazone can be decreased when used in combination with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "acarbose", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of acarbose can be decreased when used in combination with Iloperidone.", "severity": 2}
{"drug1": "doxepin", "drug2": "mesalamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of mesalamine can be decreased when used in combination with doxepin.", "severity": 2}
{"drug1": "Icatibant", "drug2": "metolazone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of metolazone can be decreased when used in combination with Icatibant.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "tolbutamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolbutamide can be decreased when used in combination with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of 4-PHENYLBUTYRIC ACID can be decreased when used in combination with Clobetasone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "carboprost trometamol", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of carboprost trometamol can be decreased when used in combination with Magnesium salicylate.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "hydrochlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of hydrochlorothiazide can be decreased when used in combination with mycophenolate mofetil.", "severity": 2}
{"drug1": "floctafenine", "drug2": "Limaprost", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Limaprost can be decreased when used in combination with floctafenine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "UMECLIDINIUM", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of UMECLIDINIUM can be decreased when used in combination with metoclopramide.", "severity": 2}
{"drug1": "naltrexone", "drug2": "oxymorphone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of oxymorphone can be decreased when used in combination with naltrexone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Sitagliptin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Sitagliptin can be decreased when used in combination with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "dobutamine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of dobutamine can be decreased when used in combination with Calcium citrate.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "clarithromycin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of clarithromycin can be decreased when used in combination with Isoflurophate.", "severity": 2}
{"drug1": "methadone", "drug2": "codeine", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of codeine can be decreased when used in combination with methadone.", "severity": 2}
{"drug1": "memantine", "drug2": "ipratropium", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ipratropium can be decreased when used in combination with memantine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "chlorothiazide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorothiazide can be decreased when used in combination with antipyrine.", "severity": 2}
{"drug1": "minocycline", "drug2": "cloxacillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of cloxacillin can be decreased when used in combination with minocycline.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Methylscopolamine bromide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Methylscopolamine bromide can be decreased when used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Bivalirudin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Bivalirudin can be decreased when used in combination with GESTODENE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of BENDROFLUMETHIAZIDE can be decreased when used in combination with mesalamine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "nateglinide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of nateglinide can be decreased when used in combination with Temsirolimus.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "Unoprostone", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Unoprostone can be decreased when used in combination with flurbiprofen.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ILOPROST", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of ILOPROST can be decreased when used in combination with mefenamic acid.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "PENTAERYTHRITOL TETRANITRATE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of PENTAERYTHRITOL TETRANITRATE can be decreased when used in combination with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Empagliflozin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Empagliflozin can be decreased when used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Alitretinoin.", "severity": 2}
{"drug1": "ceftriaxone", "drug2": "Picosulfuric acid", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with ceftriaxone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "tolazamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of tolazamide can be decreased when used in combination with DESOGESTREL.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Levonorgestrel", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Mephobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Norelgestromin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Norelgestromin can be decreased when used in combination with amobarbital.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "chlorpropamide", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of chlorpropamide can be decreased when used in combination with Paliperidone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "biperiden", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of biperiden can be decreased when used in combination with galanthamine.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Pivmecillinam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Pivampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Pivampicillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "TICARCILLIN", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of TICARCILLIN can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "Tazobactam", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of Tazobactam can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "methicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of methicillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "chlortetracycline", "drug2": "bacampicillin", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of bacampicillin can be decreased when used in combination with chlortetracycline.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "CYSTEAMINE", "interaction_type": 70, "interaction_text": "The therapeutic efficacy of CYSTEAMINE can be decreased when used in combination with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "Arformoterol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "droxidopa", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "doxapram", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "droxidopa", "drug2": "rizatriptan", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of rizatriptan.", "severity": 2}
{"drug1": "droxidopa", "drug2": "naratriptan", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of naratriptan.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "phenmetrazine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "tizanidine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "metaraminol", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "midodrine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "ARBUTAMINE may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "doxapram", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "ERGOTAMINE may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "GUANFACINE may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "Salbutamol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "epinephrine", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "brimonidine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "brimonidine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "nylidrin", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "Arformoterol may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "halothane", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "halothane may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "isoetharine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "isoetharine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "Pirlindole may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "formoterol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "formoterol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "furazolidone", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "furazolidone may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "OLODATEROL may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "sevoflurane may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "midodrine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "Lofexidine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "methyldopa", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "methyldopa may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "Salmeterol may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "ERGOTAMINE may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "HEXOPRENALINE", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "HEXOPRENALINE may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "epinastine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "epinastine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "naphazoline", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "naphazoline may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "procarbazine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "procarbazine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "brimonidine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "brimonidine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "tizanidine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "isoxsuprine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "apraclonidine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "epinephrine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Frovatriptan", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of Frovatriptan.", "severity": 2}
{"drug1": "dobutamine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "Salmeterol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "nylidrin", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "furazolidone may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "furazolidone may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "formoterol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "formoterol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "Salbutamol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Ephedrine", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of Ephedrine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "PIRBUTEROL may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "clonidine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "clonidine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "Arformoterol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "clonidine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "clonidine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "GUANFACINE may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "midodrine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "procarbazine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "procarbazine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "procarbazine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "formoterol", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "formoterol may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "methyldopa", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "methyldopa may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "midodrine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Vilazodone", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of Vilazodone.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "methoxamine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "methoxamine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "methoxamine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "dopamine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "dopamine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "dopamine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "dopamine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "metaraminol", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "brimonidine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "brimonidine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "epinephrine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "apraclonidine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "dobutamine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "OLODATEROL may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "midodrine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "apraclonidine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "droxidopa", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "guanabenz", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "guanabenz may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "midodrine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "naphazoline", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "naphazoline may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "terbutaline", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "ERGOTAMINE may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "Toloxatone may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "ritodrine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "doxapram", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "ARBUTAMINE may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "nylidrin", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "acebutolol may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "doxapram", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "isoxsuprine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "nitrous oxide may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "midodrine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "labetalol", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "labetalol may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "clonidine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "clonidine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "isoetharine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "isoetharine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "nylidrin", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "methoxamine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "Toloxatone may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "DESFLURANE may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "midodrine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "Mirabegron may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "epinephrine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "ritodrine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "Pirlindole may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "methoxamine", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "ARBUTAMINE may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "methoxamine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "doxapram", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "ARBUTAMINE may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "doxapram", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "isoxsuprine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "Salbutamol may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "celiprolol may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "guanabenz", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "guanabenz may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "isoflurane", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "isoflurane may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "ERGOTAMINE may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "dobutamine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "OLODATEROL may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "doxapram", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "epinastine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "epinastine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "enflurane", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "enflurane may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "guanabenz", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "guanabenz may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "furazolidone", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "furazolidone may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "dipivefrin may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "dobutamine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "metaraminol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "midodrine", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "HEXOPRENALINE", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "HEXOPRENALINE may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "celiprolol may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "PIRBUTEROL may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "OLODATEROL may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "dobutamine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "dobutamine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "phenmetrazine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "epinephrine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "metaraminol", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "epinastine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "epinastine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "metaraminol", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "midodrine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "PIRBUTEROL may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "dipivefrin may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "dipivefrin may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "isoxsuprine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "isoxsuprine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "naphazoline", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "naphazoline may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "dipivefrin may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "isoetharine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "isoetharine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "Toloxatone may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "OLODATEROL may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "Lofexidine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "droxidopa", "drug2": "midodrine", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of midodrine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Eletriptan", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of Eletriptan.", "severity": 2}
{"drug1": "doxapram", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "droxidopa", "drug2": "pergolide", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of pergolide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "isoxsuprine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "naphazoline", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "naphazoline may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "Arformoterol may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "Pirlindole may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "droxidopa", "drug2": "apomorphine", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of apomorphine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "guanabenz may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "Lofexidine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "metaraminol", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "ropinirole", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of ropinirole.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "HEXOPRENALINE", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "HEXOPRENALINE may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "VORTIOXETINE", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of VORTIOXETINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "HEXOPRENALINE", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "HEXOPRENALINE may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "methylphenidate may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "acebutolol may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "methoxamine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "Mirabegron may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "Salmeterol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "phenmetrazine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "phenmetrazine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "naphazoline", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "naphazoline may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "hydroxyamphetamine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "AMPHETAMINE may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "dipivefrin may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "doxapram", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "doxapram", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "methoxamine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "doxapram", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "PIRBUTEROL may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "nylidrin", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "Toloxatone may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "brimonidine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "brimonidine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "methyldopa", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "methyldopa may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "nylidrin", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "nylidrin", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "terbutaline", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "tizanidine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "tizanidine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "isoxsuprine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "isoxsuprine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "dopamine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "dopamine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "guanabenz", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "guanabenz may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "midodrine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "Pirlindole may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "epinastine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "epinastine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "metaraminol", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "midodrine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "Lofexidine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "Lofexidine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "metaraminol", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "HEXOPRENALINE", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "HEXOPRENALINE may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "DEXMEDETOMIDINE may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "droxidopa", "drug2": "sumatriptan", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of sumatriptan.", "severity": 2}
{"drug1": "methoxamine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "droxidopa", "drug2": "LISURIDE", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of LISURIDE.", "severity": 2}
{"drug1": "methoxamine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "formoterol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "formoterol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "methoxamine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "methoxamine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "dextroamphetamine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "isoproterenol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "formoterol", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "formoterol may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "metaraminol", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "AMPHETAMINE", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of AMPHETAMINE.", "severity": 2}
{"drug1": "midodrine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "methoxamine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "GUANFACINE may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "methoxamine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "methoxyflurane may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "midodrine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "midodrine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "Toloxatone may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "Mirabegron may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "acebutolol", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "acebutolol may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "metaraminol", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Almotriptan", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of Almotriptan.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "labetalol may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "tetrahydrozoline", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "tetrahydrozoline may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "droxidopa", "drug2": "norepinephrine", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of norepinephrine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "apraclonidine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "apraclonidine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "methyldopa", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "methyldopa may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "Mirabegron may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "Arformoterol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "isoetharine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "isoetharine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "DEXMEDETOMIDINE may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "metaraminol", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "Lisdexamfetamine may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "Toloxatone", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "Toloxatone may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "midodrine", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Pirlindole", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of Pirlindole.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "metaproterenol may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "droxidopa", "drug2": "zolmitriptan", "interaction_type": 71, "interaction_text": "droxidopa may increase the hypertensive activities of zolmitriptan.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "midodrine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "DEXMEDETOMIDINE may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "phenylpropanolamine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "midodrine", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "PROCATEROL may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "isoetharine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "isoetharine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "furazolidone may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "ERGOTAMINE may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "ERGOTAMINE may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "labetalol", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "labetalol may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "DEXMEDETOMIDINE may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "nylidrin", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "nylidrin may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "Pirlindole may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "Salbutamol may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "midodrine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "ritodrine", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "dobutamine", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "PIRBUTEROL may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "furazolidone", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "furazolidone may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "Salmeterol may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "procarbazine", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of procarbazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "oxymetazoline", "drug2": "bromocriptine", "interaction_type": 71, "interaction_text": "oxymetazoline may increase the hypertensive activities of bromocriptine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "dobutamine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "dobutamine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "metaraminol", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "celiprolol may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "midodrine", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "midodrine may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "methoxamine", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "methoxamine may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "doxapram", "drug2": "Phenelzine", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of Phenelzine.", "severity": 2}
{"drug1": "metaraminol", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "metaraminol may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "linezolid", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of linezolid.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "METHAMPHETAMINE may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Tedizolid phosphate", "interaction_type": 71, "interaction_text": "epinephrine may increase the hypertensive activities of Tedizolid phosphate.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "methylene blue", "interaction_type": 71, "interaction_text": "ATROPINE may increase the hypertensive activities of methylene blue.", "severity": 2}
{"drug1": "furazolidone", "drug2": "isocarboxazid", "interaction_type": 71, "interaction_text": "furazolidone may increase the hypertensive activities of isocarboxazid.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "tranylcypromine", "interaction_type": 71, "interaction_text": "Dexmethylphenidate may increase the hypertensive activities of tranylcypromine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "benzphetamine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "ritodrine", "drug2": "Atomoxetine", "interaction_type": 71, "interaction_text": "ritodrine may increase the hypertensive activities of Atomoxetine.", "severity": 2}
{"drug1": "levonordefrin", "drug2": "Toloxatone", "interaction_type": 71, "interaction_text": "levonordefrin may increase the hypertensive activities of Toloxatone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "moclobemide", "interaction_type": 71, "interaction_text": "norepinephrine may increase the hypertensive activities of moclobemide.", "severity": 2}
{"drug1": "doxapram", "drug2": "furazolidone", "interaction_type": 71, "interaction_text": "doxapram may increase the hypertensive activities of furazolidone.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "PSEUDOEPHEDRINE may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "selegiline", "interaction_type": 71, "interaction_text": "phenylephrine may increase the hypertensive activities of selegiline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "rasagiline", "interaction_type": 71, "interaction_text": "Amfepramone may increase the hypertensive activities of rasagiline.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "methylphenidate", "interaction_type": 71, "interaction_text": "TRICHLOROETHYLENE may increase the hypertensive activities of methylphenidate.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "dihydroergotamine", "interaction_type": 71, "interaction_text": "clenbuterol may increase the hypertensive activities of dihydroergotamine.", "severity": 2}
{"drug1": "Ephedrine", "drug2": "cabergoline", "interaction_type": 71, "interaction_text": "Ephedrine may increase the hypertensive activities of cabergoline.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "ERGOTAMINE", "interaction_type": 71, "interaction_text": "ARBUTAMINE may increase the hypertensive activities of ERGOTAMINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "pargyline", "interaction_type": 71, "interaction_text": "MEPHENTERMINE may increase the hypertensive activities of pargyline.", "severity": 2}
{"drug1": "terbutaline", "drug2": "methylergonovine", "interaction_type": 71, "interaction_text": "terbutaline may increase the hypertensive activities of methylergonovine.", "severity": 2}
{"drug1": "tobramycin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "dorzolamide", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of dorzolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "Bosentan", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of Bosentan which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "ketoconazole", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of ketoconazole which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "glyburide", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of glyburide which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "reserpine", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of reserpine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "nafcillin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "nafcillin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "vinblastine", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of vinblastine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "Dofetilide", "drug2": "trimethoprim", "interaction_type": 72, "interaction_text": "Dofetilide may decrease the excretion rate of trimethoprim which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "ursodiol", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of ursodiol which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "ethinyl estradiol", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of ethinyl estradiol which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "lamivudine", "drug2": "trimethoprim", "interaction_type": 72, "interaction_text": "lamivudine may decrease the excretion rate of trimethoprim which could result in a higher serum level.", "severity": 1}
{"drug1": "memantine", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "memantine may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "oxacillin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "oxacillin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "dicloxacillin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "dicloxacillin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "cimetidine", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of cimetidine which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Gemifloxacin", "drug2": "probenecid", "interaction_type": 72, "interaction_text": "Gemifloxacin may decrease the excretion rate of probenecid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "Letermovir", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of Letermovir which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "progesterone", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of progesterone which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "VERAPAMIL", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of VERAPAMIL which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "cyclosporin A", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of cyclosporin A which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "ampicillin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "ampicillin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "penicillin g", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "penicillin g may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "memantine", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "memantine may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "memantine", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "memantine may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "fusidic acid", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of fusidic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "tamoxifen", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of tamoxifen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "clofazimine", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of clofazimine which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "acemetacin", "drug2": "sulfinpyrazone", "interaction_type": 72, "interaction_text": "acemetacin may decrease the excretion rate of sulfinpyrazone which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "penicillin v", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "penicillin v may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "PONATINIB", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of PONATINIB which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "memantine", "drug2": "dorzolamide", "interaction_type": 72, "interaction_text": "memantine may decrease the excretion rate of dorzolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "PENICILLIN G PROCAINE may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Salsalate", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Salsalate which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "amoxicillin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "amoxicillin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "SIMEPREVIR", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of SIMEPREVIR which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium acetate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "Calcium acetate may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Tenofovir disoproxil", "drug2": "Cidofovir", "interaction_type": 72, "interaction_text": "Tenofovir disoproxil may decrease the excretion rate of Cidofovir which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Nepafenac", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Nepafenac which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "QUINETHAZONE", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of QUINETHAZONE which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "polythiazide", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of polythiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "metolazone", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of metolazone which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Pimecrolimus", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Pimecrolimus which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Penicillin G benzathine", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "Penicillin G benzathine may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "Aluminium hydroxide", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of Aluminium hydroxide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Amfepramone", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "Amfepramone may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "Almasilate", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of Almasilate which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "quinidine", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of quinidine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "calcium lactate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "calcium lactate may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "Aluminium", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of Aluminium which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "tiaprofenic acid", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of tiaprofenic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Magnesium salicylate", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Magnesium salicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "SODIUM BICARBONATE", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of SODIUM BICARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "mefenamic acid", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of mefenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "hydroxyamphetamine", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "hydroxyamphetamine may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "celecoxib", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of celecoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "Bismuth subcitrate potassium", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of Bismuth subcitrate potassium which could result in a higher serum level.", "severity": 1}
{"drug1": "quinidine", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "quinidine may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "chlorothiazide", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of chlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "Lumiracoxib", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of Lumiracoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "novobiocin", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of novobiocin which could result in a higher serum level.", "severity": 1}
{"drug1": "METHAMPHETAMINE", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 72, "interaction_text": "METHAMPHETAMINE may decrease the excretion rate of MAGNESIUM HYDROXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "salicylic acid", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of salicylic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "PSEUDOEPHEDRINE may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "meclofenamic acid", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of meclofenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "Lisdexamfetamine", "drug2": "Trometamol", "interaction_type": 72, "interaction_text": "Lisdexamfetamine may decrease the excretion rate of Trometamol which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "salicylamide", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of salicylamide which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium phosphate", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "Calcium phosphate may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "mycophenolic acid", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of mycophenolic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "flurbiprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of flurbiprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "resveratrol", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of resveratrol which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Lornoxicam", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Lornoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "methazolamide", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of methazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM GLUCONATE", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "CALCIUM GLUCONATE may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "ADAPALENE", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of ADAPALENE which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "ETOFENAMATE", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of ETOFENAMATE which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "NAPROXEN", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of NAPROXEN which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Glubionate calcium", "drug2": "methyclothiazide", "interaction_type": 72, "interaction_text": "Glubionate calcium may decrease the excretion rate of methyclothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "BALSALAZIDE", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of BALSALAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Apremilast", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Apremilast which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "Olsalazine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of Olsalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "indomethacin", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of indomethacin which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "Teriflunomide", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "PIRFENIDONE", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of PIRFENIDONE which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "acetazolamide", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of acetazolamide which could result in a higher serum level.", "severity": 1}
{"drug1": "dextroamphetamine", "drug2": "CALCIUM CARBONATE", "interaction_type": 72, "interaction_text": "dextroamphetamine may decrease the excretion rate of CALCIUM CARBONATE which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Icatibant", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Icatibant which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "ibuprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of ibuprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "oxyphenbutazone", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of oxyphenbutazone which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "nimesulide", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of nimesulide which could result in a higher serum level.", "severity": 1}
{"drug1": "benzphetamine", "drug2": "dichlorphenamide", "interaction_type": 72, "interaction_text": "benzphetamine may decrease the excretion rate of dichlorphenamide which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "CLONIXIN", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of CLONIXIN which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "CALCIUM CHLORIDE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 72, "interaction_text": "CALCIUM CHLORIDE may decrease the excretion rate of BENDROFLUMETHIAZIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "MEPHENTERMINE", "drug2": "MAGNESIUM OXIDE", "interaction_type": 72, "interaction_text": "MEPHENTERMINE may decrease the excretion rate of MAGNESIUM OXIDE which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Loxoprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Loxoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Droxicam", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Droxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "tolfenamic acid", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of tolfenamic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "chlorthalidone", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of chlorthalidone which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "leflunomide", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of leflunomide which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "Magaldrate", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of Magaldrate which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "netilmicin", "drug2": "sulfasalazine", "interaction_type": 72, "interaction_text": "netilmicin may decrease the excretion rate of sulfasalazine which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "diflunisal", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of diflunisal which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "doxorubicin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "doxorubicin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Propacetamol", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Propacetamol which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "trichlormethiazide", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of trichlormethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "carprofen", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of carprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "AMPHETAMINE", "drug2": "Magnesium trisilicate", "interaction_type": 72, "interaction_text": "AMPHETAMINE may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.", "severity": 1}
{"drug1": "ribostamycin", "drug2": "fenbufen", "interaction_type": 72, "interaction_text": "ribostamycin may decrease the excretion rate of fenbufen which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "Spectinomycin", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "Spectinomycin may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptozocin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "streptozocin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "cholic acid", "drug2": "Rifampicin", "interaction_type": 72, "interaction_text": "cholic acid may decrease the excretion rate of Rifampicin which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "paromomycin", "drug2": "alclofenac", "interaction_type": 72, "interaction_text": "paromomycin may decrease the excretion rate of alclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "Aceclofenac", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of Aceclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "aspirin", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of aspirin which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "tenoxicam", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of tenoxicam which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "Olopatadine", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of Olopatadine which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "nabumetone", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of nabumetone which could result in a higher serum level.", "severity": 1}
{"drug1": "kanamycin", "drug2": "ketorolac", "interaction_type": 72, "interaction_text": "kanamycin may decrease the excretion rate of ketorolac which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "oxaprozin", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of oxaprozin which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "niflumic acid", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of niflumic acid which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "streptomycin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "streptomycin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "suprofen", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of suprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "antipyrine", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of antipyrine which could result in a higher serum level.", "severity": 1}
{"drug1": "Calcium citrate", "drug2": "hydrochlorothiazide", "interaction_type": 72, "interaction_text": "Calcium citrate may decrease the excretion rate of hydrochlorothiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "etodolac", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of etodolac which could result in a higher serum level.", "severity": 1}
{"drug1": "metrizamide", "drug2": "mesalamine", "interaction_type": 72, "interaction_text": "metrizamide may decrease the excretion rate of mesalamine which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "ZILEUTON", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of ZILEUTON which could result in a higher serum level.", "severity": 1}
{"drug1": "tobramycin", "drug2": "acemetacin", "interaction_type": 72, "interaction_text": "tobramycin may decrease the excretion rate of acemetacin which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "Naftifine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of Naftifine which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "azelastine", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of azelastine which could result in a higher serum level.", "severity": 1}
{"drug1": "Valrubicin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "Valrubicin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "mycophenolate mofetil", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of mycophenolate mofetil which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "floctafenine", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of floctafenine which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "hydroflumethiazide", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of hydroflumethiazide which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "fenoprofen", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of fenoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "lithium ion", "drug2": "indapamide", "interaction_type": 72, "interaction_text": "lithium ion may decrease the excretion rate of indapamide which could result in a higher serum level.", "severity": 1}
{"drug1": "plicamycin", "drug2": "chloroquine", "interaction_type": 72, "interaction_text": "plicamycin may decrease the excretion rate of chloroquine which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "Etoricoxib", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of Etoricoxib which could result in a higher serum level.", "severity": 1}
{"drug1": "daunorubicin", "drug2": "ketoprofen", "interaction_type": 72, "interaction_text": "daunorubicin may decrease the excretion rate of ketoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "Amrubicin", "drug2": "sulindac", "interaction_type": 72, "interaction_text": "Amrubicin may decrease the excretion rate of sulindac which could result in a higher serum level.", "severity": 1}
{"drug1": "Epirubicin", "drug2": "epirizole", "interaction_type": 72, "interaction_text": "Epirubicin may decrease the excretion rate of epirizole which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "SERATRODAST", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of SERATRODAST which could result in a higher serum level.", "severity": 1}
{"drug1": "amikacin", "drug2": "diclofenac", "interaction_type": 72, "interaction_text": "amikacin may decrease the excretion rate of diclofenac which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "zaltoprofen", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of zaltoprofen which could result in a higher serum level.", "severity": 1}
{"drug1": "gentamicin", "drug2": "Masoprocol", "interaction_type": 72, "interaction_text": "gentamicin may decrease the excretion rate of Masoprocol which could result in a higher serum level.", "severity": 1}
{"drug1": "Arbekacin", "drug2": "tolmetin", "interaction_type": 72, "interaction_text": "Arbekacin may decrease the excretion rate of tolmetin which could result in a higher serum level.", "severity": 1}
{"drug1": "IDARUBICIN", "drug2": "BENZYDAMINE", "interaction_type": 72, "interaction_text": "IDARUBICIN may decrease the excretion rate of BENZYDAMINE which could result in a higher serum level.", "severity": 1}
{"drug1": "PARAMETHADIONE", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Dehydroepiandrosterone", "interaction_type": 73, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "nicotine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "diazepam", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "isradipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with sumatriptan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Gimeracil", "interaction_type": 73, "interaction_text": "The serum concentration of Gimeracil can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Silodosin", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "domperidone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "finasteride", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "riluzole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with riluzole.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with metoclopramide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "atenolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "clonazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "betahistine", "drug2": "Toloxatone", "interaction_type": 73, "interaction_text": "The serum concentration of Toloxatone can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "betahistine", "drug2": "methylene blue", "interaction_type": 73, "interaction_text": "The serum concentration of methylene blue can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "indinavir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "LEVOBUNOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOBUNOLOL can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Lornoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Lornoxicam can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "busulfan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with actinomycin D.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "topotecan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "difluprednate", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "digoxin", "drug2": "aspirin", "interaction_type": 73, "interaction_text": "The serum concentration of aspirin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "timolol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "metronidazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "sertraline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "felbamate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "vindesine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "nimesulide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nimesulide.", "severity": 2}
{"drug1": "alosetron", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "sildenafil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with methylphenidate.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Riociguat", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Pibrentasvir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Pibrentasvir.", "severity": 2}
{"drug1": "Pibrentasvir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Pibrentasvir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "busulfan", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "quinidine", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "erythromycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "prednisone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "digoxin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "digoxin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "halothane", "interaction_type": 73, "interaction_text": "The serum concentration of halothane can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "quinidine", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "promethazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Ezetimibe", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Ezetimibe.", "severity": 2}
{"drug1": "metoprolol", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with maprotiline.", "severity": 2}
{"drug1": "vinblastine", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "bupropion", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "vincristine", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "cisplatin", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with cisplatin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "quinidine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "quinidine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "amoxapine", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tenoxicam.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with sulfasalazine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "formestane", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "topotecan", "drug2": "Baricitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Baricitinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with zolmitriptan.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "CEFORANIDE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with CEFORANIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "DEXKETOPROFEN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with DEXKETOPROFEN.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cilostazol", "interaction_type": 73, "interaction_text": "The serum concentration of cilostazol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "vincristine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "vincristine", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "colchicine", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "colchicine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Efonidipine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "medrysone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Sacubitril", "interaction_type": 73, "interaction_text": "The serum concentration of Sacubitril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "pimozide", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Mometasone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Apixaban", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "histamine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "azithromycin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "cisapride", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "lithium ion", "drug2": "leflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of leflunomide can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cefazolin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with cefazolin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Olaparib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "busulfan", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "diflunisal", "interaction_type": 73, "interaction_text": "The serum concentration of diflunisal can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "salicylamide", "interaction_type": 73, "interaction_text": "The serum concentration of salicylamide can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "estrone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "carisoprodol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with carisoprodol.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "BENZYDAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of BENZYDAMINE can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "pimozide", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "epinastine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "etoposide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "budesonide", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Cladribine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with Cladribine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Calcifediol", "interaction_type": 73, "interaction_text": "The serum concentration of Calcifediol can be increased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "topotecan", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "topotecan", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "calcitriol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Silodosin", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "digoxin", "drug2": "ibuprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ibuprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Trametinib", "interaction_type": 73, "interaction_text": "The serum concentration of Trametinib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "triazolam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "prochlorperazine", "interaction_type": 73, "interaction_text": "The serum concentration of prochlorperazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "colchicine", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "piperazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with piperazine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "vincristine", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "vincristine", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "etizolam", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "raloxifene", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "nicotine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "nicotine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "triazolam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ropinirole", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Afatinib", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Trometamol", "interaction_type": 73, "interaction_text": "The serum concentration of Trometamol can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "medrysone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dapagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Dapagliflozin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ramelteon", "interaction_type": 73, "interaction_text": "The serum concentration of Ramelteon can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "propafenone", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "alosetron", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "bupropion", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "Artemether", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "warfarin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "dopamine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "quinidine", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "zolpidem", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "practolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "enalapril", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "gabapentin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with gabapentin.", "severity": 2}
{"drug1": "vincristine", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "quinidine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "tolbutamide", "interaction_type": 73, "interaction_text": "The serum concentration of tolbutamide can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with oxaprozin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "finasteride", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "isradipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "bupivacaine", "interaction_type": 73, "interaction_text": "The serum concentration of bupivacaine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nicergoline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "naloxone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "topotecan", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "dapsone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Grazoprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Grazoprevir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "loperamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "promazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "selegiline", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Doxercalciferol", "interaction_type": 73, "interaction_text": "The serum concentration of Doxercalciferol can be increased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Apremilast", "interaction_type": 73, "interaction_text": "The serum concentration of Apremilast can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Cefacetrile", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Cefacetrile.", "severity": 2}
{"drug1": "dicumarol", "drug2": "tegafur", "interaction_type": 73, "interaction_text": "The serum concentration of tegafur can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "ketoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ketoprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "busulfan", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "domperidone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "cytarabine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with olanzapine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with thiothixene.", "severity": 2}
{"drug1": "metolazone", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with tranylcypromine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Lenalidomide.", "severity": 2}
{"drug1": "Axitinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mianserin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "plicamycin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with plicamycin.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with GESTODENE.", "severity": 2}
{"drug1": "azelastine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sulfisoxazole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "equilin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ETHACRYNIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of ETHACRYNIC ACID can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "clonidine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "clonidine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "tizanidine", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "formestane", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Retapamulin", "interaction_type": 73, "interaction_text": "The serum concentration of Retapamulin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "lovastatin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Udenafil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Lumiracoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Lumiracoxib can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "practolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "digoxin", "drug2": "epoprostenol", "interaction_type": 73, "interaction_text": "The serum concentration of epoprostenol can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "lidocaine", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "argatroban", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "teniposide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "astemizole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mianserin", "interaction_type": 73, "interaction_text": "The serum concentration of mianserin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with fexofenadine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "tizanidine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "flecainide", "drug2": "lactic acid", "interaction_type": 73, "interaction_text": "The serum concentration of lactic acid can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "mianserin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "desipramine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "RIFAPENTINE", "interaction_type": 73, "interaction_text": "The serum concentration of RIFAPENTINE can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "zidovudine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "GESTODENE", "interaction_type": 73, "interaction_text": "The serum concentration of GESTODENE can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "desipramine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "montelukast", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Brivaracetam", "interaction_type": 73, "interaction_text": "The serum concentration of Brivaracetam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "formestane", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "tolbutamide", "interaction_type": 73, "interaction_text": "The serum concentration of tolbutamide can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "formestane", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Roflumilast", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Roflumilast.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "montelukast", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "memantine", "drug2": "Aluminium hydroxide", "interaction_type": 73, "interaction_text": "The serum concentration of Aluminium hydroxide can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Riociguat", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "felbamate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "difluprednate", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "cisapride", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "estazolam", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "sertraline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "Afatinib", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "trazodone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ADAPALENE", "interaction_type": 73, "interaction_text": "The serum concentration of ADAPALENE can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "busulfan", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "indapamide", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "flecainide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "topotecan", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "bepridil", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with bepridil.", "severity": 2}
{"drug1": "methadone", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Neratinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "progesterone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "resveratrol", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with resveratrol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "paramethasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with carboplatin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Propacetamol", "interaction_type": 73, "interaction_text": "The serum concentration of Propacetamol can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "paramethasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "vindesine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "morphine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "citalopram", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "bepridil", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with bepridil.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "quinidine", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with DESOGESTREL.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "clomipramine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "losartan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "protriptyline", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "aminophylline", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "vindesine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vindesine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "novobiocin", "interaction_type": 73, "interaction_text": "The serum concentration of novobiocin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "leflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of leflunomide can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "mianserin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Tazobactam", "interaction_type": 73, "interaction_text": "The serum concentration of Tazobactam can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "domperidone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ETOFENAMATE", "interaction_type": 73, "interaction_text": "The serum concentration of ETOFENAMATE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "SOMATOSTATIN", "interaction_type": 73, "interaction_text": "The serum concentration of SOMATOSTATIN can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "fenbufen", "interaction_type": 73, "interaction_text": "The serum concentration of fenbufen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "risperidone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "indapamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "azelastine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "vincristine", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "phenindione", "drug2": "tegafur", "interaction_type": 73, "interaction_text": "The serum concentration of tegafur can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "metoprolol", "drug2": "chlorpheniramine", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpheniramine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "quinacrine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "metoprolol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "diclofenac", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "nefazodone", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with IDARUBICIN.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "propafenone", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "diflunisal", "interaction_type": 73, "interaction_text": "The serum concentration of diflunisal can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "doxepin", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ETONOGESTREL", "interaction_type": 73, "interaction_text": "The serum concentration of ETONOGESTREL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ouabain", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "propafenone", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "mesalamine", "interaction_type": 73, "interaction_text": "The serum concentration of mesalamine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "alclometasone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "colchicine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "ouabain", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "cephalexin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "LEVOBUNOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOBUNOLOL can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "aspirin", "interaction_type": 73, "interaction_text": "The serum concentration of aspirin can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "pravastatin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "granisetron", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Arotinolol", "interaction_type": 73, "interaction_text": "The serum concentration of Arotinolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "lithium ion", "drug2": "BALSALAZIDE", "interaction_type": 73, "interaction_text": "The serum concentration of BALSALAZIDE can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "etodolac", "interaction_type": 73, "interaction_text": "The serum concentration of etodolac can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "glipizide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "SOFOSBUVIR", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with SOFOSBUVIR.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Melatonin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "simvastatin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "diazepam", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "loratadine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Afatinib", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "ceritinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Vismodegib", "interaction_type": 73, "interaction_text": "The serum concentration of Vismodegib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "sulfadiazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfadiazine can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "meperidine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Riociguat", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "cabergoline", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "dyphylline", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "budesonide", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ciprofloxacin.", "severity": 2}
{"drug1": "budesonide", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "busulfan", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Quinine", "drug2": "Almasilate", "interaction_type": 73, "interaction_text": "The serum concentration of Almasilate can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "busulfan", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with maprotiline.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "nadolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Vinflunine", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with Vinflunine.", "severity": 2}
{"drug1": "domperidone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with methylphenidate.", "severity": 2}
{"drug1": "labetalol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rufinamide", "interaction_type": 73, "interaction_text": "The serum concentration of Rufinamide can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "topotecan", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Mometasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "piperacillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "topotecan", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "miconazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "warfarin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "sertraline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "flecainide", "drug2": "dorzolamide", "interaction_type": 73, "interaction_text": "The serum concentration of dorzolamide can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "digoxin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "hydroxyzine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxyzine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "methoxsalen", "interaction_type": 73, "interaction_text": "The serum concentration of methoxsalen can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "clofazimine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "halothane", "interaction_type": 73, "interaction_text": "The serum concentration of halothane can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ESMOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of ESMOLOL can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Belinostat", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Belinostat.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Camazepam", "interaction_type": 73, "interaction_text": "The serum concentration of Camazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "oxprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of oxprenolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ondansetron", "interaction_type": 73, "interaction_text": "The serum concentration of ondansetron can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tiagabine", "interaction_type": 73, "interaction_text": "The serum concentration of tiagabine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "metolazone", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "folic acid", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with folic acid.", "severity": 2}
{"drug1": "formestane", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "propafenone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "colchicine", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "colchicine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "quazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "warfarin", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "cisplatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with cisplatin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "chloroquine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with tolperisone.", "severity": 2}
{"drug1": "equilin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "propafenone", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "doxepin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "propranolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Cladribine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Cladribine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "morphine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "secobarbital", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with secobarbital.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "cilostazol", "drug2": "memantine", "interaction_type": 73, "interaction_text": "The serum concentration of memantine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "thalidomide", "interaction_type": 73, "interaction_text": "The serum concentration of thalidomide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "estriol", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with estriol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "trimipramine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "benzoic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with benzoic acid.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Silodosin", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "betahistine", "drug2": "furazolidone", "interaction_type": 73, "interaction_text": "The serum concentration of furazolidone can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "selegiline", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "pimozide", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "fenoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of fenoprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "duloxetine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "alosetron", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "digitoxin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "estrone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "prazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with rosiglitazone.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Afatinib", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with leflunomide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "periciazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with leflunomide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "trazodone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Amrinone", "interaction_type": 73, "interaction_text": "The serum concentration of Amrinone can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "vindesine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "risperidone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "pimozide", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "testosterone", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lumiracoxib.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "topotecan", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "propafenone", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "nimesulide", "interaction_type": 73, "interaction_text": "The serum concentration of nimesulide can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "formestane", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "cilostazol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "vincristine", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "suprofen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with suprofen.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 73, "interaction_text": "The serum concentration of HYDROXYPROGESTERONE CAPROATE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Palonosetron", "interaction_type": 73, "interaction_text": "The serum concentration of Palonosetron can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "pergolide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "aspirin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Torasemide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Torasemide.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "colchicine", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "metformin", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with indomethacin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "vincristine", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "vincristine", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "equilin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "quinidine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "penbutolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "triazolam", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "BALSALAZIDE", "interaction_type": 73, "interaction_text": "The serum concentration of BALSALAZIDE can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "GUANFACINE", "interaction_type": 73, "interaction_text": "The serum concentration of GUANFACINE can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "duloxetine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "tetracycline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "astemizole", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "nicotine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "astemizole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "halothane", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "codeine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "prednisone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "midazolam", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Debrisoquine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "warfarin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "budesonide", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Choline magnesium trisalicylate", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Choline magnesium trisalicylate.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "modafinil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "Macitentan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "digitoxin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Lumiracoxib.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "BISOPROLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BISOPROLOL can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Varenicline", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Pinaverium.", "severity": 2}
{"drug1": "etizolam", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Epirubicin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with Epirubicin.", "severity": 2}
{"drug1": "topotecan", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "codeine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "trazodone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "pimozide", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "tretinoin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with maprotiline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Calcipotriol", "interaction_type": 73, "interaction_text": "The serum concentration of Calcipotriol can be increased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "topotecan", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "dolasetron", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "letrozole", "interaction_type": 73, "interaction_text": "The serum concentration of letrozole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Artemether", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "lovastatin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "histamine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Encainide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Encainide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Apixaban", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "imipramine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "tegafur", "interaction_type": 73, "interaction_text": "The serum concentration of tegafur can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "pimozide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "topotecan", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "spiramycin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "busulfan", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "digoxin", "drug2": "ketorolac", "interaction_type": 73, "interaction_text": "The serum concentration of ketorolac can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "digoxin", "drug2": "nabumetone", "interaction_type": 73, "interaction_text": "The serum concentration of nabumetone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "tenoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of tenoxicam can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "dihydrotachysterol", "interaction_type": 73, "interaction_text": "The serum concentration of dihydrotachysterol can be increased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "lorazepam", "interaction_type": 73, "interaction_text": "The serum concentration of lorazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "domperidone", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "norgestrel", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "pravastatin", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "haloperidol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Vinflunine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Vinflunine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "prazepam", "interaction_type": 73, "interaction_text": "The serum concentration of prazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with rasagiline.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Demecarium", "interaction_type": 73, "interaction_text": "The serum concentration of Demecarium can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "imipramine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "vindesine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vindesine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "albendazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "letrozole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "timolol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with Olsalazine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "risperidone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "equilin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "topotecan", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "topotecan", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "penbutolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "flecainide", "interaction_type": 73, "interaction_text": "The serum concentration of flecainide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "acebutolol", "interaction_type": 73, "interaction_text": "The serum concentration of acebutolol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Dexfenfluramine", "interaction_type": 73, "interaction_text": "The serum concentration of Dexfenfluramine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "fenoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of fenoprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "dicumarol", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Nitrofural.", "severity": 2}
{"drug1": "oxazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Prostaglandin E2.", "severity": 2}
{"drug1": "tizanidine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "cilostazol", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Fluciclovine (18F)", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Fluciclovine (18F).", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "ADAPALENE", "interaction_type": 73, "interaction_text": "The serum concentration of ADAPALENE can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "practolol", "interaction_type": 73, "interaction_text": "The serum concentration of practolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Bevantolol", "interaction_type": 73, "interaction_text": "The serum concentration of Bevantolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Remoxipride.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Oritavancin", "interaction_type": 73, "interaction_text": "The serum concentration of Oritavancin can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "toremifene", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "tizanidine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 73, "interaction_text": "The serum concentration of DEXMEDETOMIDINE can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "Ledipasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ledipasvir can be increased when it is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with OLODATEROL.", "severity": 2}
{"drug1": "digoxin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Axitinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ondansetron", "interaction_type": 73, "interaction_text": "The serum concentration of ondansetron can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "thioridazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "cisapride", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Artemether", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "felbamate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "celiprolol", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "propafenone", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "propafenone", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Melatonin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Melatonin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with fluvoxamine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "nefazodone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Dexfenfluramine", "interaction_type": 73, "interaction_text": "The serum concentration of Dexfenfluramine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "acebutolol", "interaction_type": 73, "interaction_text": "The serum concentration of acebutolol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "flecainide", "interaction_type": 73, "interaction_text": "The serum concentration of flecainide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Avanafil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "nadolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "rapamycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with dacarbazine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "digoxin", "drug2": "PIRFENIDONE", "interaction_type": 73, "interaction_text": "The serum concentration of PIRFENIDONE can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with leflunomide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ethanol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "indapamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "imipramine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "progesterone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "valsartan", "interaction_type": 73, "interaction_text": "The serum concentration of valsartan can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "colchicine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "ethanol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "cisapride", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "clonidine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "midazolam", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "prazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "simvastatin", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "ouabain", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "citalopram", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "pravastatin", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "triazolam", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "indapamide", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "quazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "cisapride", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "sotalol", "interaction_type": 73, "interaction_text": "The serum concentration of sotalol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "theophylline", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Imatinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "colchicine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "BALSALAZIDE", "interaction_type": 73, "interaction_text": "The serum concentration of BALSALAZIDE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "trimipramine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "propofol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "montelukast", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Eltrombopag.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "vincristine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "aspirin", "interaction_type": 73, "interaction_text": "The serum concentration of aspirin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "LEVOMENOL", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with LEVOMENOL.", "severity": 2}
{"drug1": "methotrexate", "drug2": "MEZLOCILLIN", "interaction_type": 73, "interaction_text": "The serum concentration of MEZLOCILLIN can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "felodipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "calcitriol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "propafenone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "estazolam", "interaction_type": 73, "interaction_text": "The serum concentration of estazolam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "norethindrone", "interaction_type": 73, "interaction_text": "The serum concentration of norethindrone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "lithium ion", "drug2": "diflunisal", "interaction_type": 73, "interaction_text": "The serum concentration of diflunisal can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Echothiophate", "interaction_type": 73, "interaction_text": "The serum concentration of Echothiophate can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "formestane", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "warfarin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "nateglinide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Vecuronium.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "cisapride", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "memantine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM HYDROXIDE can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "temazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "budesonide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Bosentan", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "pravastatin", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "budesonide", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "busulfan", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "etoposide", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "triamterene", "interaction_type": 73, "interaction_text": "The serum concentration of triamterene can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Netupitant.", "severity": 2}
{"drug1": "polythiazide", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "ADAPALENE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ADAPALENE.", "severity": 2}
{"drug1": "digoxin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "flumethasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "formestane", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "rapamycin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with thalidomide.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "testosterone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with APRINDINE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "paramethasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "ceftazidime", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ceftazidime.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "Safinamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "pravastatin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Varenicline", "drug2": "fleroxacin", "interaction_type": 73, "interaction_text": "The serum concentration of fleroxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "minoxidil", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with minoxidil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "LEVOMENOL", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with LEVOMENOL.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with IDARUBICIN.", "severity": 2}
{"drug1": "etizolam", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "ouabain", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 73, "interaction_text": "The serum concentration of ISOSORBIDE MONONITRATE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methoxyflurane", "interaction_type": 73, "interaction_text": "The serum concentration of methoxyflurane can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "domperidone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "albendazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "nizatidine", "interaction_type": 73, "interaction_text": "The serum concentration of nizatidine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "testosterone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "niflumic acid", "interaction_type": 73, "interaction_text": "The serum concentration of niflumic acid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "warfarin", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "vincristine", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "tolbutamide", "interaction_type": 73, "interaction_text": "The serum concentration of tolbutamide can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "meperidine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Mephobarbital", "interaction_type": 73, "interaction_text": "The serum concentration of Mephobarbital can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "deslanoside", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dorzolamide", "interaction_type": 73, "interaction_text": "The serum concentration of dorzolamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "benzphetamine", "interaction_type": 73, "interaction_text": "The serum concentration of benzphetamine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Vardenafil", "interaction_type": 73, "interaction_text": "The serum concentration of Vardenafil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "nicotine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "diflunisal", "interaction_type": 73, "interaction_text": "The serum concentration of diflunisal can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "tizanidine", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "halothane", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "vincristine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "medrysone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "theophylline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Perampanel", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "meperidine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "calcitriol", "interaction_type": 73, "interaction_text": "The serum concentration of calcitriol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Permethrin", "interaction_type": 73, "interaction_text": "The serum concentration of Permethrin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ospemifene", "interaction_type": 73, "interaction_text": "The serum concentration of Ospemifene can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "midazolam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Clevidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Clevidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "colchicine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "amikacin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with amikacin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "periciazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "midodrine", "interaction_type": 73, "interaction_text": "The serum concentration of midodrine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "vindesine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ketoprofen.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "trazodone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "clomiphene", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with clomiphene.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "memantine", "drug2": "Trometamol", "interaction_type": 73, "interaction_text": "The serum concentration of Trometamol can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "pimozide", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "nadolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "duloxetine", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "warfarin", "drug2": "tegafur", "interaction_type": 73, "interaction_text": "The serum concentration of tegafur can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with meprobamate.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Avanafil", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "cisapride", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "pravastatin", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Pomalidomide", "interaction_type": 73, "interaction_text": "The serum concentration of Pomalidomide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Quinine", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "pravastatin", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "digoxin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "epinastine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Netupitant", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Netupitant.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "L-thyroxine", "interaction_type": 73, "interaction_text": "The serum concentration of L-thyroxine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "haloperidol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "busulfan", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "valsartan", "interaction_type": 73, "interaction_text": "The serum concentration of valsartan can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "glyburide", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Masoprocol", "interaction_type": 73, "interaction_text": "The serum concentration of Masoprocol can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Dehydroepiandrosterone", "interaction_type": 73, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "flumethasone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with dacarbazine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "flecainide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "temazepam", "interaction_type": 73, "interaction_text": "The serum concentration of temazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "ketamine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "topotecan", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "caffeine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "quinidine", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "LISURIDE", "interaction_type": 73, "interaction_text": "The serum concentration of LISURIDE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "mesalamine", "interaction_type": 73, "interaction_text": "The serum concentration of mesalamine can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "tizanidine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "codeine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "naloxone", "interaction_type": 73, "interaction_text": "The serum concentration of naloxone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tripelennamine", "interaction_type": 73, "interaction_text": "The serum concentration of tripelennamine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "flurazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "difluprednate", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "difluprednate", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "thioridazine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "digoxin", "drug2": "mefenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mefenamic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "NAPROXEN", "interaction_type": 73, "interaction_text": "The serum concentration of NAPROXEN can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "triprolidine", "interaction_type": 73, "interaction_text": "The serum concentration of triprolidine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "losartan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "BUPRANOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BUPRANOLOL can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "medrysone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "astemizole", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "propofol", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with metoclopramide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "clozapine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "clozapine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "bepridil", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with bepridil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with sparfloxacin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with benztropine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "estazolam", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "alclometasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "vindesine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "fenoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of fenoprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "colchicine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "equilin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "letrozole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "vincristine", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "pergolide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "vincristine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "deslanoside", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "polythiazide", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "polythiazide", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "vincristine", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Calcifediol", "interaction_type": 73, "interaction_text": "The serum concentration of Calcifediol can be increased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "pergolide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with lomefloxacin.", "severity": 2}
{"drug1": "betahistine", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Olaparib", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "midazolam", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "oxycodone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nizatidine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Vernakalant.", "severity": 2}
{"drug1": "topotecan", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "flutamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "propafenone", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "loperamide", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Levonorgestrel", "interaction_type": 73, "interaction_text": "The serum concentration of Levonorgestrel can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Quinine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "simvastatin", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "digoxin", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "liothyronine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with liothyronine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "donepezil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ajmaline.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Pioglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Pioglitazone can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "losartan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "trazodone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "dexlansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of dexlansoprazole can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with hesperetin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "clomipramine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "terbinafine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "labetalol", "interaction_type": 73, "interaction_text": "The serum concentration of labetalol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Salsalate", "interaction_type": 73, "interaction_text": "The serum concentration of Salsalate can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with osimertinib.", "severity": 2}
{"drug1": "osimertinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with osimertinib.", "severity": 2}
{"drug1": "leflunomide", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with leflunomide.", "severity": 2}
{"drug1": "vincristine", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "azelastine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "vincristine", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "topotecan", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Risedronic acid", "interaction_type": 73, "interaction_text": "The serum concentration of Risedronic acid can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "pentoxifylline", "interaction_type": 73, "interaction_text": "The serum concentration of pentoxifylline can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "promazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "metoprolol", "drug2": "oxamniquine", "interaction_type": 73, "interaction_text": "The serum concentration of oxamniquine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "promazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "digoxin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "estrone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "colchicine", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "sulindac", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with sulindac.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "prazosin", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with prazosin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "vincristine", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "methotrexate", "drug2": "PENICILLIN G PROCAINE", "interaction_type": 73, "interaction_text": "The serum concentration of PENICILLIN G PROCAINE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cytarabine", "interaction_type": 73, "interaction_text": "The serum concentration of cytarabine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pibrentasvir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Pibrentasvir.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "leflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of leflunomide can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "carvedilol", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Dienogest", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "citalopram", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "astemizole", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "quinidine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Arformoterol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "dyphylline", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "digoxin", "drug2": "BENZYDAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of BENZYDAMINE can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "alosetron", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "ethanol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "warfarin", "drug2": "Erlotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Erlotinib can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Mepyramine", "interaction_type": 73, "interaction_text": "The serum concentration of Mepyramine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "progesterone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with rosiglitazone.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "quinidine", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "mianserin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "zolpidem", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "indapamide", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "pimozide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "citalopram", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "citalopram", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "oxamniquine", "interaction_type": 73, "interaction_text": "The serum concentration of oxamniquine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "letrozole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "risperidone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with sulfasalazine.", "severity": 2}
{"drug1": "clozapine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "argatroban", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "acebutolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "trazodone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "trazodone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "promazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "domperidone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "nefazodone", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "reserpine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with reserpine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Vandetanib", "interaction_type": 73, "interaction_text": "The serum concentration of Vandetanib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "topotecan", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "promazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "perphenazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "raloxifene", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "domperidone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Benidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Benidipine.", "severity": 2}
{"drug1": "argatroban", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "testosterone", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "methadone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "vinblastine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "promethazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "montelukast", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "domperidone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "astemizole", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "diclofenac", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "domperidone", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "prazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "topotecan", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "cabergoline", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "vindesine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "mianserin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "topotecan", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "vincristine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "ouabain", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "ESMOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of ESMOLOL can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rufinamide", "interaction_type": 73, "interaction_text": "The serum concentration of Rufinamide can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ondansetron", "interaction_type": 73, "interaction_text": "The serum concentration of ondansetron can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "topotecan", "drug2": "Vandetanib", "interaction_type": 73, "interaction_text": "The serum concentration of Vandetanib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Loxoprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Loxoprofen.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "indapamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "theophylline", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "alfacalcidol", "interaction_type": 73, "interaction_text": "The serum concentration of alfacalcidol can be increased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "theophylline", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zaltoprofen.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "estazolam", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "methotrexate", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Rosuvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Rosuvastatin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "dicloxacillin", "interaction_type": 73, "interaction_text": "The serum concentration of dicloxacillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Apremilast", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "deslanoside", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "metoprolol", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "colchicine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Lumiracoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Lumiracoxib can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "colchicine", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "propafenone", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "clozapine", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with guanabenz.", "severity": 2}
{"drug1": "progesterone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "RIFABUTIN", "interaction_type": 73, "interaction_text": "The serum concentration of RIFABUTIN can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "PARAMETHADIONE", "interaction_type": 73, "interaction_text": "The serum concentration of PARAMETHADIONE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "argatroban", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "glipizide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tapentadol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "montelukast", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "triazolam", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "loratadine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Propacetamol", "interaction_type": 73, "interaction_text": "The serum concentration of Propacetamol can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Silodosin", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "thioridazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "disopyramide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "amcinonide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "glipizide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "estazolam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "digoxin", "drug2": "Propacetamol", "interaction_type": 73, "interaction_text": "The serum concentration of Propacetamol can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "nicotine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with cholic acid.", "severity": 2}
{"drug1": "loratadine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "quetiapine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "alprazolam", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "alclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of alclofenac can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "cefoperazone", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefoperazone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "timolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "clozapine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "toremifene", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "nimesulide", "interaction_type": 73, "interaction_text": "The serum concentration of nimesulide can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "thioridazine", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "enalapril", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "lithium ion", "drug2": "mesalamine", "interaction_type": 73, "interaction_text": "The serum concentration of mesalamine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "atenolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mequitazine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with flurbiprofen.", "severity": 2}
{"drug1": "caffeine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "bepridil", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with bepridil.", "severity": 2}
{"drug1": "flunarizine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "cisapride", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "thioridazine", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Norelgestromin", "interaction_type": 73, "interaction_text": "The serum concentration of Norelgestromin can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "selegiline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "ouabain", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "Quinine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "oxaprozin", "interaction_type": 73, "interaction_text": "The serum concentration of oxaprozin can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "dapsone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "digitoxin", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "tolterodine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "quinidine", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with actinomycin D.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with actinomycin D.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Varenicline", "drug2": "Pefloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of Pefloxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "methadone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "halothane", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "halothane", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "trimipramine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "warfarin", "drug2": "ETHACRYNIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of ETHACRYNIC ACID can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pinaverium", "interaction_type": 73, "interaction_text": "The serum concentration of Pinaverium can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "citalopram", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "foscarnet", "drug2": "furosemide", "interaction_type": 73, "interaction_text": "The serum concentration of furosemide can be increased when it is combined with foscarnet.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "flunarizine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "epinastine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "theobromine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with theobromine.", "severity": 2}
{"drug1": "malathion", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with malathion.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "vincristine", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "theophylline", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "timolol", "interaction_type": 73, "interaction_text": "The serum concentration of timolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "caffeine", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Afatinib", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "etoposide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "propafenone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "mycophenolic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolic acid can be increased when it is combined with ganciclovir.", "severity": 2}
{"drug1": "sotalol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with sotalol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "lovastatin", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "indapamide", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "desipramine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Pioglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Pioglitazone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "pergolide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "nilutamide", "interaction_type": 73, "interaction_text": "The serum concentration of nilutamide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "CEFONICID", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with CEFONICID.", "severity": 2}
{"drug1": "pergolide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "SOFOSBUVIR", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with SOFOSBUVIR.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "digoxin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "digoxin", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "nefazodone", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "oxaprozin", "interaction_type": 73, "interaction_text": "The serum concentration of oxaprozin can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "tolterodine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "cisapride", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "lithium ion", "drug2": "mycophenolic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolic acid can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "efavirenz", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "pimozide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "digoxin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "selegiline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "estramustine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "CALCIUM CARBONATE", "interaction_type": 73, "interaction_text": "The serum concentration of CALCIUM CARBONATE can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Aluminium hydroxide", "interaction_type": 73, "interaction_text": "The serum concentration of Aluminium hydroxide can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "cisapride", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Netupitant.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "temazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with GESTODENE.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "etoposide", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "pimozide", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with sparfloxacin.", "severity": 2}
{"drug1": "budesonide", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "lomustine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with lomustine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "domperidone", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Riociguat", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "nilutamide", "interaction_type": 73, "interaction_text": "The serum concentration of nilutamide can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Pasireotide", "interaction_type": 73, "interaction_text": "The serum concentration of Pasireotide can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Torasemide.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "ETOFENAMATE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ETOFENAMATE.", "severity": 2}
{"drug1": "digoxin", "drug2": "ketoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ketoprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "azelastine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "vindesine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "quinidine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "enalapril", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "phenindione", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "phenindione", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "colchicine", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Olmesartan.", "severity": 2}
{"drug1": "diflorasone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "lidocaine", "drug2": "timolol", "interaction_type": 73, "interaction_text": "The serum concentration of timolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "promethazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "methadone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Olsalazine", "interaction_type": 73, "interaction_text": "The serum concentration of Olsalazine can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "colchicine", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "galanthamine", "interaction_type": 73, "interaction_text": "The serum concentration of galanthamine can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "deslanoside", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "metolazone", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Romidepsin", "interaction_type": 73, "interaction_text": "The serum concentration of Romidepsin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "vindesine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vincristine", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "finasteride", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "irinotecan", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "histamine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "codeine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "meperidine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "polythiazide", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "ketamine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with LESINURAD.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM OXIDE can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Aluminium", "interaction_type": 73, "interaction_text": "The serum concentration of Aluminium can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "indapamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cilostazol", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "dyphylline", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Silodosin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "pravastatin", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "selegiline", "drug2": "Dienogest", "interaction_type": 73, "interaction_text": "The serum concentration of Dienogest can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with NAPROXEN.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "vinblastine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "cisapride", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "nadolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Dexfenfluramine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "lovastatin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "topotecan", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Vapreotide", "interaction_type": 73, "interaction_text": "The serum concentration of Vapreotide can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "digoxin", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "estrone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "tazarotene", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tazarotene.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "clonidine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "dapsone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of 4-PHENYLBUTYRIC ACID can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "metformin", "interaction_type": 73, "interaction_text": "The serum concentration of metformin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "caffeine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "alclometasone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "carmustine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with carmustine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "doxepin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "topotecan", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "irinotecan", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "clindamycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "dexlansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of dexlansoprazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "vincristine", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Azelnidipine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "estrone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "alfuzosin", "interaction_type": 73, "interaction_text": "The serum concentration of alfuzosin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dextroamphetamine", "interaction_type": 73, "interaction_text": "The serum concentration of dextroamphetamine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "METHAMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of METHAMPHETAMINE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "miconazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Eluxadoline", "interaction_type": 73, "interaction_text": "The serum concentration of Eluxadoline can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "colchicine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "quetiapine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "halothane", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "sibutramine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "etizolam", "interaction_type": 73, "interaction_text": "The serum concentration of etizolam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "quinidine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "colchicine", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "ropinirole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "bupropion", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "clozapine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "xylometazoline", "interaction_type": 73, "interaction_text": "The serum concentration of xylometazoline can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "formestane", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "vincristine", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "diltiazem", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clopidogrel", "interaction_type": 73, "interaction_text": "The serum concentration of clopidogrel can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "Afatinib", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "selegiline", "drug2": "DESOGESTREL", "interaction_type": 73, "interaction_text": "The serum concentration of DESOGESTREL can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "quazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "cisapride", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "bupropion", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "aspirin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "bupropion", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "topotecan", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "desipramine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Quinine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "domperidone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "tinidazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "pimozide", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "domperidone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "busulfan", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "topotecan", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "dexlansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of dexlansoprazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "topotecan", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Paricalcitol", "interaction_type": 73, "interaction_text": "The serum concentration of Paricalcitol can be increased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Sestamibi", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Sestamibi.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "nimesulide", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with nimesulide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Eltrombopag.", "severity": 2}
{"drug1": "tolazamide", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with tolazamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flumazenil", "interaction_type": 73, "interaction_text": "The serum concentration of flumazenil can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "vindesine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "vindesine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "flumethasone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Crisaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Crisaborole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "vindesine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vindesine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vindesine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with doxazosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "Perampanel", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "metoprolol", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "metoprolol", "drug2": "midodrine", "interaction_type": 73, "interaction_text": "The serum concentration of midodrine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Safinamide", "interaction_type": 73, "interaction_text": "The serum concentration of Safinamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "colchicine", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "equilin", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "equilin", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "propafenone", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ADAPALENE", "interaction_type": 73, "interaction_text": "The serum concentration of ADAPALENE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "calcitriol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "doxepin", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "cephalothin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cephalothin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "promethazine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methoxsalen", "interaction_type": 73, "interaction_text": "The serum concentration of methoxsalen can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "estazolam", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "warfarin", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "bupropion", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "propranolol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "midazolam", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Almasilate", "interaction_type": 73, "interaction_text": "The serum concentration of Almasilate can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Efonidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Efonidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "pentamidine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "SOFOSBUVIR", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with SOFOSBUVIR.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "bupropion", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "spiramycin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "selegiline", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "colchicine", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "perphenazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "niclosamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with niclosamide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "midazolam", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sibutramine", "interaction_type": 73, "interaction_text": "The serum concentration of sibutramine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "amiodarone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "doxepin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with thalidomide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with thiabendazole.", "severity": 2}
{"drug1": "Mometasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "dienestrol", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with dienestrol.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "cisapride", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "timolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Tofacitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Tofacitinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cocaine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with fexofenadine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with thalidomide.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Pimecrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Pimecrolimus can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Azelnidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Azelnidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Benidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Benidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cilnidipine", "interaction_type": 73, "interaction_text": "The serum concentration of cilnidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lacidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lacidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "budesonide", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "topotecan", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "topotecan", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lormetazepam", "interaction_type": 73, "interaction_text": "The serum concentration of Lormetazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "mefloquine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "prazosin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with prazosin.", "severity": 2}
{"drug1": "prazosin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with prazosin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "digoxin", "drug2": "Flibanserin", "interaction_type": 73, "interaction_text": "The serum concentration of Flibanserin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "topotecan", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "chloroquine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "lithium ion", "drug2": "SERATRODAST", "interaction_type": 73, "interaction_text": "The serum concentration of SERATRODAST can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "cocaine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Aceclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of Aceclofenac can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "lithium ion", "drug2": "zaltoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of zaltoprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "topotecan", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "loteprednol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with phenylephrine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "progesterone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "digoxin", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "halothane", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "promethazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "citalopram", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "quinidine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "alprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of alprenolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "colchicine", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "prednisone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "prednisone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "glyburide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "domperidone", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "ondansetron", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Mometasone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "Quinine", "drug2": "SODIUM BICARBONATE", "interaction_type": 73, "interaction_text": "The serum concentration of SODIUM BICARBONATE can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "warfarin", "drug2": "Oritavancin", "interaction_type": 73, "interaction_text": "The serum concentration of Oritavancin can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "vincristine", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "quinidine", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "CARTEOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of CARTEOLOL can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Dolutegravir", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Dolutegravir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "indapamide", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "thioridazine", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dichlorphenamide", "interaction_type": 73, "interaction_text": "The serum concentration of dichlorphenamide can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "triazolam", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with nitrofurantoin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Lornoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Lornoxicam can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Artemether", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "tizanidine", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "malathion", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with malathion.", "severity": 2}
{"drug1": "Droxicam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Droxicam.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "deslanoside", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "colchicine", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "clozapine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "warfarin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "alosetron", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Macitentan", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "alosetron", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "fenbufen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with fenbufen.", "severity": 2}
{"drug1": "etodolac", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with etodolac.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "methadone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "diazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "histamine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "zopiclone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "theobromine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with theobromine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Imidafenacin", "interaction_type": 73, "interaction_text": "The serum concentration of Imidafenacin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "omeprazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "digoxin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "loratadine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "perphenazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "felbamate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with flurbiprofen.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Olaparib", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Avanafil", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "clozapine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "practolol", "interaction_type": 73, "interaction_text": "The serum concentration of practolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "mefenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mefenamic acid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "NAPROXEN", "interaction_type": 73, "interaction_text": "The serum concentration of NAPROXEN can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "pimozide", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Afatinib", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ETHACRYNIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of ETHACRYNIC ACID can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "epinastine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "domperidone", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "oxprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of oxprenolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "pimozide", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "proguanil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with gliclazide.", "severity": 2}
{"drug1": "promazine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "vindesine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "formestane", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Quinine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "alosetron", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "simvastatin", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "codeine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "topotecan", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "epirizole", "interaction_type": 73, "interaction_text": "The serum concentration of epirizole can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "lovastatin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "flunisolide", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "estramustine", "drug2": "Clodronic Acid", "interaction_type": 73, "interaction_text": "The serum concentration of Clodronic Acid can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "colchicine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ranitidine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "domperidone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tegafur", "interaction_type": 73, "interaction_text": "The serum concentration of tegafur can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "estrone", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nicotinic acid", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinic acid can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with rasagiline.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "topotecan", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "colchicine", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Permethrin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "formestane", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "carvedilol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "valsartan", "interaction_type": 73, "interaction_text": "The serum concentration of valsartan can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Safinamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "nevirapine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "prednisone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "mecamylamine", "interaction_type": 73, "interaction_text": "The serum concentration of mecamylamine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "astemizole", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "astemizole", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "warfarin", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "equilin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "Afatinib", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "prazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Quinine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "zolpidem", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "temazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "proguanil", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "morphine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "vincristine", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "vincristine", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Afatinib", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "alprazolam", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "busulfan", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "indapamide", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "riluzole", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with riluzole.", "severity": 2}
{"drug1": "alosetron", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "azelastine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "topotecan", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tenoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of tenoxicam can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "lithium ion", "drug2": "nabumetone", "interaction_type": 73, "interaction_text": "The serum concentration of nabumetone can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ketorolac", "interaction_type": 73, "interaction_text": "The serum concentration of ketorolac can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with rizatriptan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "finasteride", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Ospemifene", "interaction_type": 73, "interaction_text": "The serum concentration of Ospemifene can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "histamine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with paroxetine.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "finasteride", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "warfarin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "estrone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with irbesartan.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "felodipine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "phenindione", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "norgestrel", "interaction_type": 73, "interaction_text": "The serum concentration of norgestrel can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cisapride", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "topotecan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with dextroamphetamine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Perospirone", "interaction_type": 73, "interaction_text": "The serum concentration of Perospirone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "difluprednate", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "stavudine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with stavudine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Silodosin", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "testosterone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with olanzapine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "cocaine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "mestranol", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with mestranol.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "cilostazol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "teniposide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "DOXOFYLLINE", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Erlotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Erlotinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "topotecan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "pimozide", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "topotecan", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "acyclovir", "interaction_type": 73, "interaction_text": "The serum concentration of acyclovir can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "buspirone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "aminophylline", "interaction_type": 73, "interaction_text": "The serum concentration of aminophylline can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "aspirin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ropinirole", "interaction_type": 73, "interaction_text": "The serum concentration of ropinirole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cocaine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "dexlansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of dexlansoprazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "metolazone", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "prazosin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with prazosin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "dantrolene", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "donepezil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flunitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flunitrazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "quinidine", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "albendazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "vindesine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "colchicine", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "donepezil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "vincristine", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "ketamine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "vincristine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "nicotine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "vincristine", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "pimozide", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with fluvoxamine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Efonidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Efonidipine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Efonidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Efonidipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Sestamibi", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Sestamibi.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "midazolam", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "enalapril", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "practolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "NAPROXEN", "interaction_type": 73, "interaction_text": "The serum concentration of NAPROXEN can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "mefenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mefenamic acid can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "simvastatin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Silodosin", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "busulfan", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "busulfan", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "midazolam", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "diltiazem", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "flecainide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "topotecan", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "topotecan", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "granisetron", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Drospirenone", "interaction_type": 73, "interaction_text": "The serum concentration of Drospirenone can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "theophylline", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "phenindione", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "argatroban", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "vindesine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "azelastine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "digoxin", "drug2": "fenoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of fenoprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "donepezil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "theophylline", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "donepezil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "theophylline", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "theophylline", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Afatinib", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "loperamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "vindesine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "epirizole", "interaction_type": 73, "interaction_text": "The serum concentration of epirizole can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Quinine", "drug2": "Trometamol", "interaction_type": 73, "interaction_text": "The serum concentration of Trometamol can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "glyburide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "astemizole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with mefenamic acid.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "prednisone", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "loperamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "codeine", "interaction_type": 73, "interaction_text": "The serum concentration of codeine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ketoprofen.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Apremilast", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "domperidone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "piperacillin", "interaction_type": 73, "interaction_text": "The serum concentration of piperacillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "secobarbital", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with secobarbital.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "lidocaine", "drug2": "BISOPROLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BISOPROLOL can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Olopatadine", "interaction_type": 73, "interaction_text": "The serum concentration of Olopatadine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "midazolam", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "teniposide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Silodosin", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "metolazone", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ACENOCOUMAROL", "interaction_type": 73, "interaction_text": "The serum concentration of ACENOCOUMAROL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nicotine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ciclesonide", "interaction_type": 73, "interaction_text": "The serum concentration of Ciclesonide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "promethazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cisapride", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "quinidine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tenoxicam.", "severity": 2}
{"drug1": "selegiline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "valsartan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with valsartan.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Vismodegib", "interaction_type": 73, "interaction_text": "The serum concentration of Vismodegib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "trazodone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "desipramine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Frovatriptan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "dipyridamole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with dipyridamole.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "famciclovir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "flutamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "Pinaverium", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Pinaverium.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "gliclazide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with gliclazide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "cephalexin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Silodosin", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "mifepristone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "promazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "prazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "pravastatin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "prednisone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "carprofen", "interaction_type": 73, "interaction_text": "The serum concentration of carprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "sertraline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "busulfan", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with thiabendazole.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Pazopanib", "interaction_type": 73, "interaction_text": "The serum concentration of Pazopanib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Glecaprevir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Glecaprevir.", "severity": 2}
{"drug1": "Glecaprevir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Glecaprevir.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "ethanol", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "methadone", "drug2": "formestane", "interaction_type": 73, "interaction_text": "The serum concentration of formestane can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "sertraline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "decamethonium", "interaction_type": 73, "interaction_text": "The serum concentration of decamethonium can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "astemizole", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "metolazone", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "clindamycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "vincristine", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "vinblastine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "triamterene", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with triamterene.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "mianserin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "thioridazine", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with ribostamycin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "equilin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "vincristine", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "colchicine", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Icatibant", "interaction_type": 73, "interaction_text": "The serum concentration of Icatibant can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "colchicine", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sevoflurane", "interaction_type": 73, "interaction_text": "The serum concentration of sevoflurane can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "methotrexate", "drug2": "BENZYDAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of BENZYDAMINE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Perospirone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with NORGESTIMATE.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "captopril", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with captopril.", "severity": 2}
{"drug1": "estazolam", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with rosiglitazone.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "mianserin", "interaction_type": 73, "interaction_text": "The serum concentration of mianserin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "desipramine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "triazolam", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Olopatadine", "interaction_type": 73, "interaction_text": "The serum concentration of Olopatadine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Technetium Tc 99m mebrofenin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Technetium Tc 99m mebrofenin.", "severity": 2}
{"drug1": "Neratinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Asenapine", "interaction_type": 73, "interaction_text": "The serum concentration of Asenapine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Vernakalant", "interaction_type": 73, "interaction_text": "The serum concentration of Vernakalant can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "ketamine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "digoxin", "drug2": "alclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of alclofenac can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "finasteride", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "diphenhydramine", "interaction_type": 73, "interaction_text": "The serum concentration of diphenhydramine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "acyclovir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with acyclovir.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "piperazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with piperazine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "dexlansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of dexlansoprazole can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "cisapride", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Medroxyprogesterone acetate", "interaction_type": 73, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "pravastatin", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Quinine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "felodipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nicotinamide", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinamide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Lanreotide", "interaction_type": 73, "interaction_text": "The serum concentration of Lanreotide can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "methadone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "methadone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "topotecan", "interaction_type": 73, "interaction_text": "The serum concentration of topotecan can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "SULFAMOXOLE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with SULFAMOXOLE.", "severity": 2}
{"drug1": "pravastatin", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "metformin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "cocaine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "tolfenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tolfenamic acid can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "etizolam", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Pioglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Pioglitazone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "colchicine", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "desipramine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "digoxin", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "digoxin", "drug2": "Lenalidomide", "interaction_type": 73, "interaction_text": "The serum concentration of Lenalidomide can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "topotecan", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "naloxone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with lomefloxacin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "estazolam", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "estradiol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "quinidine", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "quinidine", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "propofol", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "topotecan", "interaction_type": 73, "interaction_text": "The serum concentration of topotecan can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "pentamidine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ROSOXACIN.", "severity": 2}
{"drug1": "amiodarone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with guanabenz.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "vindesine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "sertraline", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with acetylcholine.", "severity": 2}
{"drug1": "letrozole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "SOFOSBUVIR", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with SOFOSBUVIR.", "severity": 2}
{"drug1": "SOFOSBUVIR", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with SOFOSBUVIR.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "niflumic acid", "interaction_type": 73, "interaction_text": "The serum concentration of niflumic acid can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "indapamide", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "cilostazol", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "granisetron", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "doxepin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Eplerenone", "interaction_type": 73, "interaction_text": "The serum concentration of Eplerenone can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "midazolam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "alclometasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "dapsone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "thiotepa", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "selegiline", "drug2": "Drospirenone", "interaction_type": 73, "interaction_text": "The serum concentration of Drospirenone can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "desipramine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "pimozide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "GESTODENE", "interaction_type": 73, "interaction_text": "The serum concentration of GESTODENE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Diacerein", "interaction_type": 73, "interaction_text": "The serum concentration of Diacerein can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "ropinirole", "interaction_type": 73, "interaction_text": "The serum concentration of ropinirole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Afatinib", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "sulfaphenazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfaphenazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "epirizole", "interaction_type": 73, "interaction_text": "The serum concentration of epirizole can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "difluprednate", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "alprazolam", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "busulfan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "cefadroxil", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefadroxil.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "lamivudine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with lamivudine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "estrone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "sildenafil", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "topotecan", "interaction_type": 73, "interaction_text": "The serum concentration of topotecan can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "flurbiprofen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with flurbiprofen.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "disulfiram", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "imipramine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "busulfan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "promazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "budesonide", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "formestane", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "domperidone", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "practolol", "interaction_type": 73, "interaction_text": "The serum concentration of practolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Bevantolol", "interaction_type": 73, "interaction_text": "The serum concentration of Bevantolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "busulfan", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Varenicline", "drug2": "Gatifloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of Gatifloxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "flumethasone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Hexobarbital", "interaction_type": 73, "interaction_text": "The serum concentration of Hexobarbital can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "digoxin", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Lornoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Lornoxicam can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "diazepam", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with irbesartan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "flunisolide", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "digoxin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "topotecan", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "L-thyroxine", "interaction_type": 73, "interaction_text": "The serum concentration of L-thyroxine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "meperidine", "interaction_type": 73, "interaction_text": "The serum concentration of meperidine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "colchicine", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "phenindione", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "colchicine", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with resveratrol.", "severity": 2}
{"drug1": "morphine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "diflorasone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Olaparib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "digoxin", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "doxepin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "RIFABUTIN", "interaction_type": 73, "interaction_text": "The serum concentration of RIFABUTIN can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "oxazepam", "interaction_type": 73, "interaction_text": "The serum concentration of oxazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "granisetron", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "progesterone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "indapamide", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with olanzapine.", "severity": 2}
{"drug1": "pergolide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Crisaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Crisaborole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "astemizole", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "astemizole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with maprotiline.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "ipratropium", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "SERTINDOLE", "interaction_type": 73, "interaction_text": "The serum concentration of SERTINDOLE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "mianserin", "interaction_type": 73, "interaction_text": "The serum concentration of mianserin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "indapamide", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "estradiol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nicotinamide", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinamide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "propofol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "indapamide", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Avanafil", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "zopiclone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "vincristine", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "metformin", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Clevidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Clevidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "antipyrine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "methylene blue", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "propranolol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Quinine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Arformoterol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "dyphylline", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "cilostazol", "interaction_type": 73, "interaction_text": "The serum concentration of cilostazol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "dyphylline", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "RIFAPENTINE", "interaction_type": 73, "interaction_text": "The serum concentration of RIFAPENTINE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tripelennamine", "interaction_type": 73, "interaction_text": "The serum concentration of tripelennamine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "bupropion", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "betahistine", "drug2": "rasagiline", "interaction_type": 73, "interaction_text": "The serum concentration of rasagiline can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "methylene blue", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "selegiline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "halcinonide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "nifedipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "topotecan", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "labetalol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "lovastatin", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "lovastatin", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "bupropion", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "busulfan", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "domperidone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with IDARUBICIN.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with IDARUBICIN.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "betamethasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "meperidine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "budesonide", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "promethazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "teniposide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "menadione", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with menadione.", "severity": 2}
{"drug1": "thiopental", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with thiopental.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Dienogest", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "pravastatin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Technetium Tc 99m mebrofenin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Technetium Tc 99m mebrofenin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Metipranolol", "interaction_type": 73, "interaction_text": "The serum concentration of Metipranolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "enalapril", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "felodipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "clonidine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "imipramine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "formestane", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "tizanidine", "drug2": "lomefloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of lomefloxacin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "vincristine", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "buspirone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "vincristine", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ajmaline", "interaction_type": 73, "interaction_text": "The serum concentration of ajmaline can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with carboplatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "halcinonide", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "halcinonide", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "caffeine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Prostaglandin E2.", "severity": 2}
{"drug1": "colchicine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "promethazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "digoxin", "drug2": "Masoprocol", "interaction_type": 73, "interaction_text": "The serum concentration of Masoprocol can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "betahistine", "drug2": "procarbazine", "interaction_type": 73, "interaction_text": "The serum concentration of procarbazine can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "alprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of alprenolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "tizanidine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "busulfan", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "desipramine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "bupropion", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "raloxifene", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "bupropion", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "memantine", "interaction_type": 73, "interaction_text": "The serum concentration of memantine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Alitretinoin.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "citalopram", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "vinblastine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "celiprolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "toremifene", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with epoprostenol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with thalidomide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "Darunavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "manidipine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with manidipine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "mesalamine", "interaction_type": 73, "interaction_text": "The serum concentration of mesalamine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Debrisoquine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Norelgestromin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Norelgestromin.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with mefenamic acid.", "severity": 2}
{"drug1": "estradiol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "oxprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of oxprenolol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "suprofen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with suprofen.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 73, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "topotecan", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "atenolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "bupropion", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "PERHEXILINE", "interaction_type": 73, "interaction_text": "The serum concentration of PERHEXILINE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "zonisamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "simvastatin", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "digoxin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Artemether", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "domperidone", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "norgestrel", "interaction_type": 73, "interaction_text": "The serum concentration of norgestrel can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "sulfisoxazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with sulfisoxazole.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "digitoxin", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "methadone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "diphenhydramine", "interaction_type": 73, "interaction_text": "The serum concentration of diphenhydramine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "estrone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "cisapride", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "dapsone", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "Afatinib", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Mometasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "testosterone", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with salicylic acid.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "colchicine", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "digoxin", "drug2": "Nepafenac", "interaction_type": 73, "interaction_text": "The serum concentration of Nepafenac can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "metolazone", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "epinastine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "prednisone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "acemetacin", "interaction_type": 73, "interaction_text": "The serum concentration of acemetacin can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "loperamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "etizolam", "interaction_type": 73, "interaction_text": "The serum concentration of etizolam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "warfarin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "buspirone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "metoprolol", "drug2": "moclobemide", "interaction_type": 73, "interaction_text": "The serum concentration of moclobemide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Escitalopram", "interaction_type": 73, "interaction_text": "The serum concentration of Escitalopram can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "IDARUBICIN", "interaction_type": 73, "interaction_text": "The serum concentration of IDARUBICIN can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "lomefloxacin", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with lomefloxacin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "granisetron", "interaction_type": 73, "interaction_text": "The serum concentration of granisetron can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "metoprolol", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ESMOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of ESMOLOL can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "digitoxin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "propafenone", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cephalexin", "interaction_type": 73, "interaction_text": "The serum concentration of cephalexin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "argatroban", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "perphenazine", "interaction_type": 73, "interaction_text": "The serum concentration of perphenazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "cisapride", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "colchicine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with doxazosin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "vindesine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "loratadine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "pimozide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "nicotine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "digoxin", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "caffeine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "sibutramine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "nadolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "amobarbital", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with amobarbital.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pioglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Pioglitazone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Metipranolol", "interaction_type": 73, "interaction_text": "The serum concentration of Metipranolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "LEVOBUNOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOBUNOLOL can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "imipramine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "Febuxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Febuxostat can be increased when it is combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Vilazodone", "interaction_type": 73, "interaction_text": "The serum concentration of Vilazodone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "promazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with APRINDINE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Liotrix", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Liotrix.", "severity": 2}
{"drug1": "Gadoxetic acid", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Gadoxetic acid.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "promazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "promazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "topotecan", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Clofarabine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Bendamustine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "cabergoline", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "colchicine", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Loxoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of Loxoprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Droxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Droxicam can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Benidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Benidipine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "methotrexate", "drug2": "CLONIXIN", "interaction_type": 73, "interaction_text": "The serum concentration of CLONIXIN can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "labetalol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "amcinonide", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "ethanol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "propafenone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "triazolam", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Safinamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Pefloxacin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "alosetron", "interaction_type": 73, "interaction_text": "The serum concentration of alosetron can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Debrisoquine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "zaleplon", "interaction_type": 73, "interaction_text": "The serum concentration of zaleplon can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "warfarin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with benztropine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ropinirole", "interaction_type": 73, "interaction_text": "The serum concentration of ropinirole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "pravastatin", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "cyclobenzaprine", "interaction_type": 73, "interaction_text": "The serum concentration of cyclobenzaprine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Permethrin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "celiprolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Riociguat", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "morphine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "etoposide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "propafenone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "diltiazem", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Axitinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "desipramine", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "topotecan", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "doxepin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "alosetron", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "doxepin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "cilostazol", "interaction_type": 73, "interaction_text": "The serum concentration of cilostazol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Riociguat", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cilostazol", "drug2": "OXCARBAZEPINE", "interaction_type": 73, "interaction_text": "The serum concentration of OXCARBAZEPINE can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "temazepam", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with sulfasalazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "estrone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "alosetron", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "clozapine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "riluzole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with riluzole.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with dextroamphetamine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "efavirenz", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "quinidine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "periciazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "mebendazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "loratadine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Afatinib", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "periciazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sulfadiazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfadiazine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "diphenhydramine", "interaction_type": 73, "interaction_text": "The serum concentration of diphenhydramine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "PERHEXILINE", "interaction_type": 73, "interaction_text": "The serum concentration of PERHEXILINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "nabumetone", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with nabumetone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "cisapride", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "pimozide", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "pimozide", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "cocaine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with fluvoxamine.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "methadone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "leflunomide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with leflunomide.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "granisetron", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "halcinonide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "irinotecan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "digoxin", "drug2": "Lornoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Lornoxicam can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "felodipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "medrysone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "norepinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of norepinephrine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with osimertinib.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "theophylline", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with sumatriptan.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "flunarizine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "letrozole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "enalapril", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "loratadine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "methicillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with methicillin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "vincristine", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "erythromycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "cilostazol", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "quinidine", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with zaltoprofen.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "etizolam", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "prednisone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "medrysone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "vincristine", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Letermovir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "granisetron", "interaction_type": 73, "interaction_text": "The serum concentration of granisetron can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "codeine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "modafinil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "busulfan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "desipramine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "thioridazine", "drug2": "perphenazine", "interaction_type": 73, "interaction_text": "The serum concentration of perphenazine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "periciazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Ceftobiprole", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Ceftobiprole.", "severity": 2}
{"drug1": "sildenafil", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "zolpidem", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "GESTODENE", "interaction_type": 73, "interaction_text": "The serum concentration of GESTODENE can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "pimozide", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with dextroamphetamine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Silodosin", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Quinine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "citalopram", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "indapamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "methotrexate", "drug2": "oxacillin", "interaction_type": 73, "interaction_text": "The serum concentration of oxacillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "flurbiprofen", "interaction_type": 73, "interaction_text": "The serum concentration of flurbiprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "indapamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "topotecan", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "topotecan", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "modafinil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "thioridazine", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "bupropion", "drug2": "clopidogrel", "interaction_type": 73, "interaction_text": "The serum concentration of clopidogrel can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "atenolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "ganciclovir", "interaction_type": 73, "interaction_text": "The serum concentration of ganciclovir can be increased when it is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "budesonide", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "bupropion", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "histamine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "etizolam", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "propafenone", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Valganciclovir.", "severity": 2}
{"drug1": "cisapride", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "cisapride", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "aspirin", "interaction_type": 73, "interaction_text": "The serum concentration of aspirin can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "selegiline", "drug2": "norgestrel", "interaction_type": 73, "interaction_text": "The serum concentration of norgestrel can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "flumethasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "histamine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "metolazone", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "methotrexate", "drug2": "acemetacin", "interaction_type": 73, "interaction_text": "The serum concentration of acemetacin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "ketorolac", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ketorolac.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "simvastatin", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "topotecan", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "cisapride", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "topotecan", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "topotecan", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Dehydroepiandrosterone", "interaction_type": 73, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Tapentadol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "clozapine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "medrysone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "alfacalcidol", "interaction_type": 73, "interaction_text": "The serum concentration of alfacalcidol can be increased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "pravastatin", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "propranolol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fludiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of fludiazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "flumethasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "letrozole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "vindesine", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "topotecan", "drug2": "Erlotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Erlotinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "bacampicillin", "interaction_type": 73, "interaction_text": "The serum concentration of bacampicillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "methicillin", "interaction_type": 73, "interaction_text": "The serum concentration of methicillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "tiaprofenic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tiaprofenic acid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "methotrexate", "drug2": "TICARCILLIN", "interaction_type": 73, "interaction_text": "The serum concentration of TICARCILLIN can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Pivampicillin", "interaction_type": 73, "interaction_text": "The serum concentration of Pivampicillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Pivmecillinam", "interaction_type": 73, "interaction_text": "The serum concentration of Pivmecillinam can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "tizanidine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with amsacrine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ropivacaine", "interaction_type": 73, "interaction_text": "The serum concentration of Ropivacaine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Asenapine", "interaction_type": 73, "interaction_text": "The serum concentration of Asenapine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "promethazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "teniposide", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "halothane", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "modafinil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "estradiol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "quinidine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "digoxin", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "lomustine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with lomustine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nimesulide", "interaction_type": 73, "interaction_text": "The serum concentration of nimesulide can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Delorazepam", "interaction_type": 73, "interaction_text": "The serum concentration of Delorazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "metolazone", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "clonidine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "zonisamide", "interaction_type": 73, "interaction_text": "The serum concentration of zonisamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "promethazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "topotecan", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "tiaprofenic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tiaprofenic acid can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "halothane", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "oxycodone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "Axitinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "desipramine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "toremifene", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "indapamide", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "indapamide", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "colchicine", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "vincristine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "topotecan", "interaction_type": 73, "interaction_text": "The serum concentration of topotecan can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Rosuvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Rosuvastatin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "difluprednate", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Silodosin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "losartan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "memantine", "drug2": "Aluminium", "interaction_type": 73, "interaction_text": "The serum concentration of Aluminium can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "memantine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM OXIDE can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "selegiline", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "etoposide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Artemether", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Axitinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "testosterone", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methoxsalen", "interaction_type": 73, "interaction_text": "The serum concentration of methoxsalen can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "cisapride", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "topotecan", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "acebutolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "miconazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "Apixaban", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "triazolam", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "Valganciclovir", "interaction_type": 73, "interaction_text": "The serum concentration of Valganciclovir can be increased when it is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "isradipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Quinine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Magaldrate", "interaction_type": 73, "interaction_text": "The serum concentration of Magaldrate can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Vinflunine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Vinflunine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "etizolam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "sertraline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "imipramine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "naloxone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Crisaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Crisaborole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "foscarnet", "drug2": "Torasemide", "interaction_type": 73, "interaction_text": "The serum concentration of Torasemide can be increased when it is combined with foscarnet.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "aminophylline", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "caffeine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Crisaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Crisaborole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "paramethasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ajmaline.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clorazepate", "interaction_type": 73, "interaction_text": "The serum concentration of clorazepate can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "etizolam", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Bosentan", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "desipramine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "Bosentan", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ropinirole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Afatinib", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "enalapril", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "etoposide", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "malathion", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with malathion.", "severity": 2}
{"drug1": "felodipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "amoxapine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "warfarin", "interaction_type": 73, "interaction_text": "The serum concentration of warfarin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clonazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clonazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "vincristine", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "promazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "colchicine", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "carprofen", "interaction_type": 73, "interaction_text": "The serum concentration of carprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "domperidone", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "metoprolol", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "propranolol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "celiprolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "terbinafine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "lamivudine", "interaction_type": 73, "interaction_text": "The serum concentration of lamivudine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "theophylline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "phenytoin", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "indapamide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "metoprolol", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Imatinib", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "loratadine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Magnesium salicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium salicylate can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "buspirone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Azelnidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Azelnidipine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "chloroquine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nateglinide", "interaction_type": 73, "interaction_text": "The serum concentration of nateglinide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "flutamide", "interaction_type": 73, "interaction_text": "The serum concentration of flutamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "bupropion", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "cisapride", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Olaparib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "digoxin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "desipramine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "clozapine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "montelukast", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "dantrolene", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "budesonide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "metolazone", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "buspirone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Pazopanib", "interaction_type": 73, "interaction_text": "The serum concentration of Pazopanib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "diazepam", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "digoxin", "drug2": "epirizole", "interaction_type": 73, "interaction_text": "The serum concentration of epirizole can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "paramethasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Dexfenfluramine.", "severity": 2}
{"drug1": "budesonide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Tramadol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "isoniazid", "drug2": "ethionamide", "interaction_type": 73, "interaction_text": "The serum concentration of ethionamide can be increased when it is combined with isoniazid.", "severity": 2}
{"drug1": "budesonide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "prazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "etizolam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Rotigotine", "interaction_type": 73, "interaction_text": "The serum concentration of Rotigotine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "acebutolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "desipramine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "ceritinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "citalopram", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "budesonide", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "budesonide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Neratinib", "interaction_type": 73, "interaction_text": "The serum concentration of Neratinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "pimozide", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "modafinil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "pimozide", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dexfenfluramine.", "severity": 2}
{"drug1": "pimozide", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Amrubicin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with Amrubicin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "busulfan", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "budesonide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "triazolam", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "chloroquine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Aripiprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Aripiprazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "metoclopramide", "interaction_type": 73, "interaction_text": "The serum concentration of metoclopramide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "lovastatin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Letermovir.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Aceclofenac.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "carprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with carprofen.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "formestane", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "oxprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of oxprenolol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Afatinib", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "suprofen", "interaction_type": 73, "interaction_text": "The serum concentration of suprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "topotecan", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "lorazepam", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with lorazepam.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "promazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Dolutegravir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Dolutegravir.", "severity": 2}
{"drug1": "Dolutegravir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Dolutegravir.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "cabergoline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "folic acid", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with folic acid.", "severity": 2}
{"drug1": "digoxin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "colchicine", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "tolfenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tolfenamic acid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "colchicine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "propofol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ipratropium", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "zaleplon", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "topiramate", "interaction_type": 73, "interaction_text": "The serum concentration of topiramate can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "phenytoin", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Metipranolol", "interaction_type": 73, "interaction_text": "The serum concentration of Metipranolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "indapamide", "interaction_type": 73, "interaction_text": "The serum concentration of indapamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "ethanol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "galanthamine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "tolterodine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "astemizole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "zidovudine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "vincristine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "medrysone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "isradipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "thiamylal", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "phenindione", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "digoxin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "alosetron", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Bevantolol", "interaction_type": 73, "interaction_text": "The serum concentration of Bevantolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "topotecan", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "memantine", "drug2": "Almasilate", "interaction_type": 73, "interaction_text": "The serum concentration of Almasilate can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "doxepin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "nateglinide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "Afatinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "pimozide", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Safinamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lormetazepam", "interaction_type": 73, "interaction_text": "The serum concentration of Lormetazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "memantine", "drug2": "Magaldrate", "interaction_type": 73, "interaction_text": "The serum concentration of Magaldrate can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "indinavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with clenbuterol.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "clindamycin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Quinine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "famciclovir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "digoxin", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Vilanterol", "interaction_type": 73, "interaction_text": "The serum concentration of Vilanterol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "dyphylline", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "suprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with suprofen.", "severity": 2}
{"drug1": "Afatinib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "zaltoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of zaltoprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Aceclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of Aceclofenac can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "SERATRODAST", "interaction_type": 73, "interaction_text": "The serum concentration of SERATRODAST can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Olmesartan", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Olmesartan.", "severity": 2}
{"drug1": "aspirin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "ambroxol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "pimozide", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "imipramine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "thiothixene", "interaction_type": 73, "interaction_text": "The serum concentration of thiothixene can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pipotiazine", "interaction_type": 73, "interaction_text": "The serum concentration of Pipotiazine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Rupatadine", "interaction_type": 73, "interaction_text": "The serum concentration of Rupatadine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "Varenicline", "drug2": "sparfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of sparfloxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "trazodone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "mianserin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "promazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "salicylamide", "interaction_type": 73, "interaction_text": "The serum concentration of salicylamide can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "alprenolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "Cladribine", "interaction_type": 73, "interaction_text": "The serum concentration of Cladribine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "formestane", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "formestane", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "promethazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Quinine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Magnesium trisilicate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium trisilicate can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "topotecan", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "difluprednate", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "itraconazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "flecainide", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "digoxin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "miconazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Torasemide.", "severity": 2}
{"drug1": "donepezil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "flecainide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Loxoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of Loxoprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Droxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Droxicam can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "CLONIXIN", "interaction_type": 73, "interaction_text": "The serum concentration of CLONIXIN can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "cilostazol", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "ketamine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "colchicine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Riociguat", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "domperidone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "vincristine", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "promethazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "Varenicline", "drug2": "epinastine", "interaction_type": 73, "interaction_text": "The serum concentration of epinastine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "felodipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "estramustine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "clozapine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "estazolam", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "formestane", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "prednisone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "propafenone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "CLONIXIN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with CLONIXIN.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "equilin", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nicotinamide", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinamide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Torasemide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "vincristine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "formestane", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "perphenazine", "interaction_type": 73, "interaction_text": "The serum concentration of perphenazine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "isradipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "haloperidol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "finasteride", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "vincristine", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "acebutolol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "colchicine", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "colchicine", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Arformoterol.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "formoterol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with formoterol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "indomethacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with indomethacin.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "triazolam", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "diazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Propacetamol", "interaction_type": 73, "interaction_text": "The serum concentration of Propacetamol can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Choline magnesium trisalicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Choline magnesium trisalicylate can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with salicylic acid.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "finasteride", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "histamine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Quinine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "isradipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "budesonide", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "busulfan", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "metolazone", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "busulfan", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dienogest", "interaction_type": 73, "interaction_text": "The serum concentration of Dienogest can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "disulfiram", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Norelgestromin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Norelgestromin.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "quinacrine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "naloxone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "busulfan", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Tapentadol.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Tapentadol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Medroxyprogesterone acetate", "interaction_type": 73, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "imipramine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "etoposide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "dopamine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "phenindione", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "domperidone", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "domperidone", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "penicillin g", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with penicillin g.", "severity": 2}
{"drug1": "teniposide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "protriptyline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "etizolam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "sulfasalazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfasalazine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "aminophylline", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "promazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "malathion", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with malathion.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "theophylline", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "vincristine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Eszopiclone", "interaction_type": 73, "interaction_text": "The serum concentration of Eszopiclone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "methadone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Pimecrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Pimecrolimus can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "colchicine", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "oxyphenbutazone", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenbutazone can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "triazolam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "calcitriol", "interaction_type": 73, "interaction_text": "The serum concentration of calcitriol can be increased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "etizolam", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "triazolam", "interaction_type": 73, "interaction_text": "The serum concentration of triazolam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "digoxin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "quazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "quinidine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ethylmorphine", "interaction_type": 73, "interaction_text": "The serum concentration of Ethylmorphine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "midazolam", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cinnarizine", "interaction_type": 73, "interaction_text": "The serum concentration of cinnarizine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "ropinirole", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "topotecan", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "deslanoside", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "etizolam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Axitinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "astemizole", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "flutamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "nizatidine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with nizatidine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "ketamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "aminophylline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Vinflunine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Vinflunine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "BALSALAZIDE", "interaction_type": 73, "interaction_text": "The serum concentration of BALSALAZIDE can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "letrozole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Trabectedin", "interaction_type": 73, "interaction_text": "The serum concentration of Trabectedin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "lithium ion", "drug2": "PIRFENIDONE", "interaction_type": 73, "interaction_text": "The serum concentration of PIRFENIDONE can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "equilin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "Quinine", "drug2": "MAGNESIUM OXIDE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM OXIDE can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Aluminium", "interaction_type": 73, "interaction_text": "The serum concentration of Aluminium can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "gemcitabine", "interaction_type": 73, "interaction_text": "The serum concentration of gemcitabine can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "pravastatin", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with fexofenadine.", "severity": 2}
{"drug1": "aspirin", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "modafinil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "vindesine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with NAPROXEN.", "severity": 2}
{"drug1": "busulfan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "loteprednol", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "medrysone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "acemetacin", "interaction_type": 73, "interaction_text": "The serum concentration of acemetacin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with rasagiline.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "dolasetron", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "ritonavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "diflunisal", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with diflunisal.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with OLODATEROL.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "disulfiram", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Dehydroepiandrosterone", "interaction_type": 73, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "promazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "Afatinib", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "clofazimine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Dienogest", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Olopatadine", "interaction_type": 73, "interaction_text": "The serum concentration of Olopatadine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "donepezil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "promethazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "promethazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "diflunisal", "interaction_type": 73, "interaction_text": "The serum concentration of diflunisal can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Apixaban", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "cilostazol", "interaction_type": 73, "interaction_text": "The serum concentration of cilostazol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "riluzole", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with riluzole.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "mianserin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "mianserin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "azithromycin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "vincristine", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "vincristine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "promazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "azelastine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "etoposide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "alosetron", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "alosetron", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "nicardipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Eslicarbazepine acetate", "interaction_type": 73, "interaction_text": "The serum concentration of Eslicarbazepine acetate can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ketobemidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ketobemidone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "SERATRODAST", "interaction_type": 73, "interaction_text": "The serum concentration of SERATRODAST can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "doxepin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Olsalazine", "interaction_type": 73, "interaction_text": "The serum concentration of Olsalazine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Tiludronic Acid", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Tiludronic Acid.", "severity": 2}
{"drug1": "digoxin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "diazepam", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "medrysone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "topotecan", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "galanthamine", "interaction_type": 73, "interaction_text": "The serum concentration of galanthamine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "zopiclone", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "argatroban", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "midazolam", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "indapamide", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "teniposide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "flutamide", "interaction_type": 73, "interaction_text": "The serum concentration of flutamide can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with levodopa.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "desipramine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "selegiline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "nafcillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with xylometazoline.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "loratadine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "nicotine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Amrinone", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Amrinone.", "severity": 2}
{"drug1": "epinastine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "budesonide", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Mometasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "phenylephrine", "drug2": "Propacetamol", "interaction_type": 73, "interaction_text": "The serum concentration of Propacetamol can be increased when it is combined with phenylephrine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Rufinamide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "lomustine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with lomustine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tolbutamide", "interaction_type": 73, "interaction_text": "The serum concentration of tolbutamide can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "ADAPALENE", "interaction_type": 73, "interaction_text": "The serum concentration of ADAPALENE can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "clozapine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "sertraline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "selegiline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "zopiclone", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "topotecan", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "thioridazine", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "selegiline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "selegiline", "drug2": "GESTODENE", "interaction_type": 73, "interaction_text": "The serum concentration of GESTODENE can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "aspirin", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "nimodipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "didanosine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with didanosine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "glipizide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "teniposide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Levalbuterol.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "famciclovir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "clonidine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "quinidine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "prednisone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "prednisone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "etizolam", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nitric oxide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "tiaprofenic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tiaprofenic acid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "Nebivolol", "interaction_type": 73, "interaction_text": "The serum concentration of Nebivolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "sulfadiazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfadiazine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "loteprednol", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "miconazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Lenalidomide.", "severity": 2}
{"drug1": "citalopram", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "colchicine", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "vindesine", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vindesine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "estazolam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "formestane", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "colchicine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "prednisone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "colchicine", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "loperamide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "domperidone", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "methotrexate", "drug2": "epirizole", "interaction_type": 73, "interaction_text": "The serum concentration of epirizole can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "PIRFENIDONE", "interaction_type": 73, "interaction_text": "The serum concentration of PIRFENIDONE can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "vincristine", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "oxyphenbutazone", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with oxyphenbutazone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "propafenone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "cefmetazole", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefmetazole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "diphenhydramine", "interaction_type": 73, "interaction_text": "The serum concentration of diphenhydramine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "indapamide", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "moclobemide", "interaction_type": 73, "interaction_text": "The serum concentration of moclobemide can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "famotidine", "interaction_type": 73, "interaction_text": "The serum concentration of famotidine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Salsalate", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Salsalate.", "severity": 2}
{"drug1": "colchicine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ELIGLUSTAT", "interaction_type": 73, "interaction_text": "The serum concentration of ELIGLUSTAT can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "betahistine", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "timolol", "interaction_type": 73, "interaction_text": "The serum concentration of timolol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "nadolol", "interaction_type": 73, "interaction_text": "The serum concentration of nadolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "isradipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "methadone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ketoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ketoprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Levetiracetam.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "dapsone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Arformoterol.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "calcitriol", "interaction_type": 73, "interaction_text": "The serum concentration of calcitriol can be increased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "buspirone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ruxolitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Ruxolitinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Estrone sulfate", "interaction_type": 73, "interaction_text": "The serum concentration of Estrone sulfate can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "caffeine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "memantine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 73, "interaction_text": "The serum concentration of Bismuth subcitrate potassium can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "finasteride", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "digoxin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "clonazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "busulfan", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "modafinil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "imipramine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "nimesulide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nimesulide.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with tazarotene.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dexfenfluramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "indinavir", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "vincristine", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "metronidazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with arsenic trioxide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "meropenem", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with meropenem.", "severity": 2}
{"drug1": "glyburide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with gliclazide.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "prazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "tolmetin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with tolmetin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "digoxin", "drug2": "mycophenolic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "ROXATIDINE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of ROXATIDINE ACETATE can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "teniposide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Sitaxsentan.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with Bendamustine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "glucosamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with glucosamine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "losartan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "colchicine", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Macitentan", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "dapsone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "metolazone", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "floctafenine", "interaction_type": 73, "interaction_text": "The serum concentration of floctafenine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "chloroquine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "cytarabine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "galanthamine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "vindesine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ajmaline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "lithium ion", "drug2": "fenbufen", "interaction_type": 73, "interaction_text": "The serum concentration of fenbufen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "pimozide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "colchicine", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "niclosamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with niclosamide.", "severity": 2}
{"drug1": "prednisone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lornoxicam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "ketamine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "tetracycline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "flumethasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ropinirole", "interaction_type": 73, "interaction_text": "The serum concentration of ropinirole can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "praziquantel", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "Avanafil", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "digoxin", "drug2": "Droxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Droxicam can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "digoxin", "drug2": "tolfenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tolfenamic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Loxoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of Loxoprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "digoxin", "drug2": "CLONIXIN", "interaction_type": 73, "interaction_text": "The serum concentration of CLONIXIN can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "quinidine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "quinidine", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "propafenone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "glimepiride", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with glimepiride.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "metronidazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "zolpidem", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Olaparib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "digitoxin", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "colchicine", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Icatibant", "interaction_type": 73, "interaction_text": "The serum concentration of Icatibant can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "trazodone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Melatonin.", "severity": 2}
{"drug1": "dapsone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Safinamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with paroxetine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Liotrix", "interaction_type": 73, "interaction_text": "The serum concentration of Liotrix can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "barnidipine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "phenindione", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Calcipotriol", "interaction_type": 73, "interaction_text": "The serum concentration of Calcipotriol can be increased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "antipyrine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "nadolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "histamine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "polythiazide", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "ceritinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "donepezil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Riociguat", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "estrone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "azelastine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "cocaine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "pimozide", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pimozide", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "phenindione", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "tegafur", "interaction_type": 73, "interaction_text": "The serum concentration of tegafur can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "promazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "topotecan", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "domperidone", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with thalidomide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "imipramine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "epinastine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "lithium ion", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "triazolam", "interaction_type": 73, "interaction_text": "The serum concentration of triazolam can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "topotecan", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Ezetimibe", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Ezetimibe.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Afatinib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with amsacrine.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "vincristine", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "quinidine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "caffeine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "cytarabine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "colchicine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "flecainide", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "halothane", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "vincristine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Apremilast", "interaction_type": 73, "interaction_text": "The serum concentration of Apremilast can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Rosuvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Rosuvastatin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "granisetron", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "salicylamide", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with salicylamide.", "severity": 2}
{"drug1": "cefotiam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefotiam.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "triazolam", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "medrysone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "timolol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nimodipine", "interaction_type": 73, "interaction_text": "The serum concentration of nimodipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "carvedilol", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Cariprazine", "interaction_type": 73, "interaction_text": "The serum concentration of Cariprazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "floctafenine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with floctafenine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "cytarabine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "desipramine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "theophylline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Diacerein", "interaction_type": 73, "interaction_text": "The serum concentration of Diacerein can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "vincristine", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with fluvoxamine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexchlorpheniramine maleate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ELIGLUSTAT", "interaction_type": 73, "interaction_text": "The serum concentration of ELIGLUSTAT can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "loratadine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Avanafil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "etodolac", "interaction_type": 73, "interaction_text": "The serum concentration of etodolac can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Eltrombopag.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "indapamide", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with IDARUBICIN.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "codeine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with oxiconazole.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Levonorgestrel", "interaction_type": 73, "interaction_text": "The serum concentration of Levonorgestrel can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "prazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "paramethasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "cilostazol", "interaction_type": 73, "interaction_text": "The serum concentration of cilostazol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Salsalate", "interaction_type": 73, "interaction_text": "The serum concentration of Salsalate can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "simvastatin", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Magnesium salicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium salicylate can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "meclofenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of meclofenamic acid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "budesonide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "domperidone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "imipramine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "clonidine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Melatonin.", "severity": 2}
{"drug1": "topotecan", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "risperidone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "phenindione", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "flutamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Clofarabine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "phenindione", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "epinastine", "interaction_type": 73, "interaction_text": "The serum concentration of epinastine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "pravastatin", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "colchicine", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "cefotaxime", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefotaxime.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "equilin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "testosterone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "celecoxib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "betamethasone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "vindesine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with ranitidine.", "severity": 2}
{"drug1": "vindesine", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "losartan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "phenindione", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "metoprolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "metoprolol", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "progesterone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "risperidone", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "theophylline", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Udenafil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "digoxin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "flecainide", "interaction_type": 73, "interaction_text": "The serum concentration of flecainide can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "sotalol", "interaction_type": 73, "interaction_text": "The serum concentration of sotalol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Erlotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Erlotinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "toremifene", "interaction_type": 73, "interaction_text": "The serum concentration of toremifene can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "buspirone", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "warfarin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "cilostazol", "drug2": "warfarin", "interaction_type": 73, "interaction_text": "The serum concentration of warfarin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "colchicine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "bupropion", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "desipramine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "digoxin", "drug2": "flurbiprofen", "interaction_type": 73, "interaction_text": "The serum concentration of flurbiprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "morphine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "alclofenac", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with alclofenac.", "severity": 2}
{"drug1": "flutamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "desipramine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "pyridostigmine", "interaction_type": 73, "interaction_text": "The serum concentration of pyridostigmine can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chlordiazepoxide", "interaction_type": 73, "interaction_text": "The serum concentration of chlordiazepoxide can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with zolmitriptan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "meclofenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of meclofenamic acid can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "colchicine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "astemizole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "indinavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "digoxin", "drug2": "acemetacin", "interaction_type": 73, "interaction_text": "The serum concentration of acemetacin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "propafenone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "vincristine", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "ketoprofen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ketoprofen.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "timolol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tolfenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tolfenamic acid can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "fusidic acid", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with fusidic acid.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "estradiol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Ospemifene", "interaction_type": 73, "interaction_text": "The serum concentration of Ospemifene can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "topotecan", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Neratinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 73, "interaction_text": "The serum concentration of DEXMEDETOMIDINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "phenytoin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "midazolam", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "cilostazol", "interaction_type": 73, "interaction_text": "The serum concentration of cilostazol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "eperisone", "interaction_type": 73, "interaction_text": "The serum concentration of eperisone can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "methadone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "cocaine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "tenoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of tenoxicam can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "busulfan", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "thiotepa", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "digoxin", "drug2": "tiaprofenic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tiaprofenic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "ceritinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nicergoline.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "ouabain", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "theobromine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with theobromine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "busulfan", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Udenafil", "interaction_type": 73, "interaction_text": "The serum concentration of Udenafil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with paroxetine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Levalbuterol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Cefacetrile", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Cefacetrile.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "theophylline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Diacerein", "interaction_type": 73, "interaction_text": "The serum concentration of Diacerein can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "dapsone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "prednisone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "labetalol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "pravastatin", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "vincristine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "tinidazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "suprofen", "interaction_type": 73, "interaction_text": "The serum concentration of suprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Artemether", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "vincristine", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "losartan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "trimipramine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ondansetron", "interaction_type": 73, "interaction_text": "The serum concentration of ondansetron can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "estradiol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "BUPRANOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BUPRANOLOL can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "BOPINDOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BOPINDOLOL can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Magnesium salicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium salicylate can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Salsalate", "interaction_type": 73, "interaction_text": "The serum concentration of Salsalate can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "ibuprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ibuprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "clonidine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "oxycodone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "propofol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with OLODATEROL.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "TAMSULOSIN", "interaction_type": 73, "interaction_text": "The serum concentration of TAMSULOSIN can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Eprosartan", "interaction_type": 73, "interaction_text": "The serum concentration of Eprosartan can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "granisetron", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "granisetron", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "lithium ion", "drug2": "suprofen", "interaction_type": 73, "interaction_text": "The serum concentration of suprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Torasemide.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "cisapride", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "carvedilol", "drug2": "sulfadiazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfadiazine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "felbamate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "amobarbital", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with amobarbital.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "selegiline", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "indapamide", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "felbamate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "propranolol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "desipramine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "dyphylline", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "budesonide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Avanafil", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with moclobemide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dolutegravir", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Dolutegravir.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "VORTIOXETINE", "interaction_type": 73, "interaction_text": "The serum concentration of VORTIOXETINE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "promazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "digoxin", "drug2": "carprofen", "interaction_type": 73, "interaction_text": "The serum concentration of carprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Propacetamol", "interaction_type": 73, "interaction_text": "The serum concentration of Propacetamol can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "vindesine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "promazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "formestane", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "lithium ion", "drug2": "mycophenolate mofetil", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolate mofetil can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "disulfiram", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "donepezil", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "metformin", "interaction_type": 73, "interaction_text": "The serum concentration of metformin can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "Varenicline", "drug2": "cinoxacin", "interaction_type": 73, "interaction_text": "The serum concentration of cinoxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "didanosine", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with didanosine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "lovastatin", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "propranolol", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "dolasetron", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "warfarin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "glipizide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "irbesartan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with irbesartan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "GUANFACINE", "interaction_type": 73, "interaction_text": "The serum concentration of GUANFACINE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "prazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "propafenone", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "topotecan", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "tolterodine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "metolazone", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metolazone", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "ropinirole", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "calcitriol", "interaction_type": 73, "interaction_text": "The serum concentration of calcitriol can be increased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "warfarin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "halothane", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "naloxone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "vincristine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "flunisolide", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "equilin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "nicotine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "doxepin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "sildenafil", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "estradiol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "sildenafil", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "morphine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "morphine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "salicylamide", "interaction_type": 73, "interaction_text": "The serum concentration of salicylamide can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "foscarnet", "drug2": "bumetanide", "interaction_type": 73, "interaction_text": "The serum concentration of bumetanide can be increased when it is combined with foscarnet.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Indacaterol", "interaction_type": 73, "interaction_text": "The serum concentration of Indacaterol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "temazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "colchicine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "topotecan", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "morphine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "oxazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "clozapine", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "clozapine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "prazosin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with prazosin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "digitoxin", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "glipizide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Apremilast", "interaction_type": 73, "interaction_text": "The serum concentration of Apremilast can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "estrone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "estrone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "zolpidem", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "vincristine", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with doxazosin.", "severity": 2}
{"drug1": "clonazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "phenindione", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Bedaquiline", "interaction_type": 73, "interaction_text": "The serum concentration of Bedaquiline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Fluticasone furoate", "interaction_type": 73, "interaction_text": "The serum concentration of Fluticasone furoate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "estramustine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "toremifene", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Delorazepam", "interaction_type": 73, "interaction_text": "The serum concentration of Delorazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with rasagiline.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with cilnidipine.", "severity": 2}
{"drug1": "ceritinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "cabergoline", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Perampanel", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "clonidine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "busulfan", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ropinirole", "interaction_type": 73, "interaction_text": "The serum concentration of ropinirole can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "digoxin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "prednisone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "glyburide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "felodipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with hesperetin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Quinine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 73, "interaction_text": "The serum concentration of Bismuth subcitrate potassium can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "metformin", "drug2": "cephalexin", "interaction_type": 73, "interaction_text": "The serum concentration of cephalexin can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "letrozole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "digoxin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "alclometasone", "interaction_type": 73, "interaction_text": "The serum concentration of alclometasone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "topotecan", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "colchicine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "promazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "tolmetin", "interaction_type": 73, "interaction_text": "The serum concentration of tolmetin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with NAPROXEN.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "oxymorphone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymorphone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "zaleplon", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "cisplatin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with cisplatin.", "severity": 2}
{"drug1": "digoxin", "drug2": "sulfasalazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfasalazine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "digoxin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "metoprolol", "drug2": "rosiglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of rosiglitazone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "losartan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "bupropion", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "estazolam", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "quinidine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Vismodegib", "interaction_type": 73, "interaction_text": "The serum concentration of Vismodegib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "estazolam", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "quinidine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "mianserin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "triazolam", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "propafenone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Magaldrate", "interaction_type": 73, "interaction_text": "The serum concentration of Magaldrate can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "deslanoside", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "fludiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of fludiazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "simvastatin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "hesperetin", "interaction_type": 73, "interaction_text": "The serum concentration of hesperetin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Afatinib", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "digoxin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "sertraline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "tolmetin", "interaction_type": 73, "interaction_text": "The serum concentration of tolmetin can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "colchicine", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "dopamine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "vincristine", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "vincristine", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "periciazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "albendazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "cisapride", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with sumatriptan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "indapamide", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "ergocalciferol", "interaction_type": 73, "interaction_text": "The serum concentration of ergocalciferol can be increased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "theophylline", "interaction_type": 73, "interaction_text": "The serum concentration of theophylline can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Aceclofenac.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "topotecan", "drug2": "hesperetin", "interaction_type": 73, "interaction_text": "The serum concentration of hesperetin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "vindesine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "glyburide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "dapsone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Olopatadine", "interaction_type": 73, "interaction_text": "The serum concentration of Olopatadine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with rosiglitazone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "propafenone", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Quinine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "irbesartan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with irbesartan.", "severity": 2}
{"drug1": "nefazodone", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Olsalazine", "interaction_type": 73, "interaction_text": "The serum concentration of Olsalazine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "cisapride", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "celecoxib", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "felodipine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "flecainide", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "BENZYDAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of BENZYDAMINE can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "digoxin", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Delafloxacin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Delafloxacin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "ouabain", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "donepezil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "tolbutamide", "interaction_type": 73, "interaction_text": "The serum concentration of tolbutamide can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "tinidazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ELIGLUSTAT", "interaction_type": 73, "interaction_text": "The serum concentration of ELIGLUSTAT can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "vindesine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 73, "interaction_text": "The serum concentration of TROLAMINE SALICYLATE can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "budesonide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "colchicine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "vindesine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Varenicline", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "vincristine", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "itraconazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "topotecan", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "etizolam", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "phenytoin", "drug2": "triazolam", "interaction_type": 73, "interaction_text": "The serum concentration of triazolam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "promazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "methotrexate", "drug2": "amoxicillin", "interaction_type": 73, "interaction_text": "The serum concentration of amoxicillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "azlocillin", "interaction_type": 73, "interaction_text": "The serum concentration of azlocillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "digoxin", "drug2": "leflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of leflunomide can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Pimecrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Pimecrolimus can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "methotrexate", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "digoxin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "Tigecycline", "interaction_type": 73, "interaction_text": "The serum concentration of Tigecycline can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Olaparib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "thiabendazole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with thiabendazole.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "colchicine", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "allylestrenol", "interaction_type": 73, "interaction_text": "The serum concentration of allylestrenol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "chloral hydrate", "interaction_type": 73, "interaction_text": "The serum concentration of chloral hydrate can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "celiprolol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "estramustine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "quazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "thiotepa", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Vilazodone", "interaction_type": 73, "interaction_text": "The serum concentration of Vilazodone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "flurazepam", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "aspirin", "interaction_type": 73, "interaction_text": "The serum concentration of aspirin can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "tizanidine", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "citalopram", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "astemizole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "topotecan", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "indapamide", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "BOPINDOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BOPINDOLOL can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "BUPRANOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BUPRANOLOL can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "pimozide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "equilin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "periciazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "risperidone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "manidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with manidipine.", "severity": 2}
{"drug1": "quazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "pimozide", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "miconazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Choline magnesium trisalicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Choline magnesium trisalicylate can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Diacerein", "interaction_type": 73, "interaction_text": "The serum concentration of Diacerein can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "digoxin", "drug2": "oxyphenbutazone", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenbutazone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "granisetron", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "budesonide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with methylphenidate.", "severity": 2}
{"drug1": "estrone", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "midazolam", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "donepezil", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "domperidone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "dapsone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "albendazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "valsartan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with valsartan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "promethazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "selegiline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "midazolam", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "estramustine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "ouabain", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "phenindione", "drug2": "chloral hydrate", "interaction_type": 73, "interaction_text": "The serum concentration of chloral hydrate can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "digoxin", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Nebivolol", "interaction_type": 73, "interaction_text": "The serum concentration of Nebivolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "ceftriaxone", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ceftriaxone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "gliclazide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with gliclazide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "theophylline", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "isoniazid", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with isoniazid.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "triamterene", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with triamterene.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "quinacrine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with thalidomide.", "severity": 2}
{"drug1": "vincristine", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "meclofenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of meclofenamic acid can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "vincristine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "aminophylline", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "doxepin", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with DESOGESTREL.", "severity": 2}
{"drug1": "colchicine", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "phenytoin", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "finasteride", "interaction_type": 73, "interaction_text": "The serum concentration of finasteride can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "estazolam", "interaction_type": 73, "interaction_text": "The serum concentration of estazolam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "etodolac", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with etodolac.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dantrolene", "interaction_type": 73, "interaction_text": "The serum concentration of dantrolene can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "indapamide", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "theophylline", "drug2": "methotrexate", "interaction_type": 73, "interaction_text": "The serum concentration of methotrexate can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "cytarabine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "etizolam", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "glyburide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clorazepate", "interaction_type": 73, "interaction_text": "The serum concentration of clorazepate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "triamcinolone", "interaction_type": 73, "interaction_text": "The serum concentration of triamcinolone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "propranolol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Vernakalant.", "severity": 2}
{"drug1": "vindesine", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "montelukast", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nimodipine", "interaction_type": 73, "interaction_text": "The serum concentration of nimodipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "quetiapine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "prednisone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "alfacalcidol", "interaction_type": 73, "interaction_text": "The serum concentration of alfacalcidol can be increased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "amcinonide", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "diltiazem", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with OLODATEROL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "periciazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "barnidipine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "bezafibrate", "interaction_type": 73, "interaction_text": "The serum concentration of bezafibrate can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "albendazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Debrisoquine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "digoxin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with rasagiline.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Remoxipride.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "estramustine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "betamethasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "felodipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Vilazodone", "interaction_type": 73, "interaction_text": "The serum concentration of Vilazodone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "methadone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Arbekacin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with Arbekacin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "CORTISONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CORTISONE ACETATE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Perospirone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "paramethasone", "interaction_type": 73, "interaction_text": "The serum concentration of paramethasone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "flunarizine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "pimozide", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "busulfan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "penbutolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "etizolam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "topotecan", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Nitrofural.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chlorpheniramine", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpheniramine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "chlorpheniramine", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpheniramine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "granisetron", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Magnesium trisilicate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium trisilicate can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "quinidine", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "colchicine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "domperidone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "halothane", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "warfarin", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "zaltoprofen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zaltoprofen.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "vindesine", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with salicylic acid.", "severity": 2}
{"drug1": "oxacillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with oxacillin.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "epinastine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "propafenone", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "toremifene", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "letrozole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Lacidipine.", "severity": 2}
{"drug1": "equilin", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "propranolol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "vincristine", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "tinidazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "losartan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "methylene blue", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "metformin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "penbutolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Imatinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "quinidine", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "colchicine", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "diltiazem", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "methotrexate", "drug2": "carprofen", "interaction_type": 73, "interaction_text": "The serum concentration of carprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "indapamide", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "cilostazol", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "gliclazide", "interaction_type": 73, "interaction_text": "The serum concentration of gliclazide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "betahistine", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "nifedipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "pergolide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "etizolam", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Silodosin", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "cisapride", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ibuprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ibuprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "halcinonide", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "cisapride", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "pimozide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "tretinoin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "topotecan", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "alprazolam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "nifedipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with levodopa.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with doxazosin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with olanzapine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "cocaine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "spiramycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "azelastine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Fingolimod", "interaction_type": 73, "interaction_text": "The serum concentration of Fingolimod can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "busulfan", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "loperamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with tazarotene.", "severity": 2}
{"drug1": "Silodosin", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "zopiclone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "memantine", "drug2": "SODIUM BICARBONATE", "interaction_type": 73, "interaction_text": "The serum concentration of SODIUM BICARBONATE can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "clindamycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "pimozide", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "cefuroxime", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefuroxime.", "severity": 2}
{"drug1": "thioridazine", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "flumethasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "montelukast", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "thioridazine", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "etoposide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "ambroxol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "betahistine", "drug2": "Pirlindole", "interaction_type": 73, "interaction_text": "The serum concentration of Pirlindole can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "budesonide", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "domperidone", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "vindesine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "mefloquine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "quinidine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "Varenicline", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "promazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Mometasone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "digoxin", "drug2": "BALSALAZIDE", "interaction_type": 73, "interaction_text": "The serum concentration of BALSALAZIDE can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Yohimbine", "interaction_type": 73, "interaction_text": "The serum concentration of Yohimbine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "busulfan", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "morphine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "chlordiazepoxide", "interaction_type": 73, "interaction_text": "The serum concentration of chlordiazepoxide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "montelukast", "interaction_type": 73, "interaction_text": "The serum concentration of montelukast can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "colchicine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dehydroepiandrosterone", "interaction_type": 73, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "metolazone", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "imipenem", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with imipenem.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "propafenone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Letermovir.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "losartan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "clozapine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Fidaxomicin.", "severity": 2}
{"drug1": "etizolam", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "flurazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "etizolam", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "formestane", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "vindesine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "DOXOFYLLINE", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "betamethasone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "miconazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "meperidine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with QUINESTROL.", "severity": 2}
{"drug1": "moclobemide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with moclobemide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "proguanil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "DOXOFYLLINE", "drug2": "lincomycin", "interaction_type": 73, "interaction_text": "The serum concentration of lincomycin can be increased when it is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "ketamine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "vincristine", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "morphine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Silodosin", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "polythiazide", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "periciazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Rifaximin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifaximin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "imipramine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "methylene blue", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "methylene blue", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "etoposide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Silodosin", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "epinastine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "streptomycin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with streptomycin.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cisapride", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "pimozide", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "ETONOGESTREL", "interaction_type": 73, "interaction_text": "The serum concentration of ETONOGESTREL can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "imipramine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Quinine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "medrysone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "isradipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "topotecan", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Tapentadol.", "severity": 2}
{"drug1": "digoxin", "drug2": "floctafenine", "interaction_type": 73, "interaction_text": "The serum concentration of floctafenine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "perphenazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "diclofenac", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "estrone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "periciazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "digoxin", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "flurbiprofen", "interaction_type": 73, "interaction_text": "The serum concentration of flurbiprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "simvastatin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "ketoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ketoprofen can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "gentamicin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with gentamicin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "protriptyline", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "haloperidol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "cisplatin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with cisplatin.", "severity": 2}
{"drug1": "proguanil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Methylnaltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of Methylnaltrexone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "piperacillin", "interaction_type": 73, "interaction_text": "The serum concentration of piperacillin can be increased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "vincristine", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "vincristine", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "promethazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "topotecan", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Macitentan", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "ELIGLUSTAT", "interaction_type": 73, "interaction_text": "The serum concentration of ELIGLUSTAT can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "domperidone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "flumethasone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "digoxin", "drug2": "mesalamine", "interaction_type": 73, "interaction_text": "The serum concentration of mesalamine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "modafinil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "quinidine", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "quinidine", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "vincristine", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "metolazone", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "DEXKETOPROFEN", "interaction_type": 73, "interaction_text": "The serum concentration of DEXKETOPROFEN can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "tolfenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tolfenamic acid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chlordiazepoxide", "interaction_type": 73, "interaction_text": "The serum concentration of chlordiazepoxide can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "mebendazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "bupropion", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "bupropion", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "astemizole", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "norethindrone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "desipramine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "budesonide", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of 4-PHENYLBUTYRIC ACID can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "trimipramine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "losartan", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "methylene blue", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "vincristine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "metronidazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "albendazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "diazepam", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "digitoxin", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Prostaglandin E2.", "severity": 2}
{"drug1": "lidocaine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "epirizole", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with epirizole.", "severity": 2}
{"drug1": "zopiclone", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "topotecan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "disopyramide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with penicillin g.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with NAPROXEN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "protriptyline", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "digoxin", "drug2": "Apremilast", "interaction_type": 73, "interaction_text": "The serum concentration of Apremilast can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "indinavir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "loteprednol", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "topotecan", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "lamivudine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with lamivudine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "budesonide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Quinine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM HYDROXIDE can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "domperidone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "domperidone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "raloxifene", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "domperidone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "midazolam", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Bendamustine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Dolutegravir", "interaction_type": 73, "interaction_text": "The serum concentration of Dolutegravir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "naloxone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "mequitazine", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "mequitazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "digoxin", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "topotecan", "drug2": "Dabrafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Dabrafenib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Norelgestromin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Norelgestromin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Afatinib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Darunavir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "prednisone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "betamethasone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "finasteride", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "medrysone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "equilin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "theophylline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "leflunomide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with leflunomide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "ouabain", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "estazolam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "propofol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "vincristine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Sitaxsentan.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "medrysone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "penbutolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Naloxegol", "interaction_type": 73, "interaction_text": "The serum concentration of Naloxegol can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "nifedipine", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "cilostazol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ixabepilone", "interaction_type": 73, "interaction_text": "The serum concentration of Ixabepilone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "celiprolol", "interaction_type": 73, "interaction_text": "The serum concentration of celiprolol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "ritonavir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "zolpidem", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with maprotiline.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Epirubicin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Epirubicin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Gliquidone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nortriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of nortriptyline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ADINAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of ADINAZOLAM can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Vernakalant.", "severity": 2}
{"drug1": "osimertinib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "quinidine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "quinidine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "mefenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mefenamic acid can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "NAPROXEN", "interaction_type": 73, "interaction_text": "The serum concentration of NAPROXEN can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "tizanidine", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Pipotiazine", "interaction_type": 73, "interaction_text": "The serum concentration of Pipotiazine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "METHSUXIMIDE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with METHSUXIMIDE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with zolmitriptan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cisapride", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "sertraline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "alprazolam", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "nicotine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "estramustine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "codeine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "clomiphene", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with clomiphene.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with sulfasalazine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Silodosin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "budesonide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "promazine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "proguanil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "phenytoin", "drug2": "barnidipine", "interaction_type": 73, "interaction_text": "The serum concentration of barnidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "DEFLAZACORT", "interaction_type": 73, "interaction_text": "The serum concentration of DEFLAZACORT can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "tizanidine", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lumiracoxib.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "vincristine", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "colchicine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "lovastatin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "midazolam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "midazolam", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "colchicine", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "niflumic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with niflumic acid.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "etizolam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "topotecan", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "sulfasalazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfasalazine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Lornoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Lornoxicam can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "progesterone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "lovastatin", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "digoxin", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "cefazolin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefazolin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "ouabain", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "labetalol", "interaction_type": 73, "interaction_text": "The serum concentration of labetalol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "docetaxel", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "digoxin", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "etizolam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "alosetron", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chlorpheniramine", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpheniramine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Macitentan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "metolazone", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "valsartan", "interaction_type": 73, "interaction_text": "The serum concentration of valsartan can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "metolazone", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "metolazone", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "imipramine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "disopyramide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Alitretinoin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Alitretinoin.", "severity": 2}
{"drug1": "theophylline", "drug2": "pentoxifylline", "interaction_type": 73, "interaction_text": "The serum concentration of pentoxifylline can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "colchicine", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Oritavancin", "interaction_type": 73, "interaction_text": "The serum concentration of Oritavancin can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "colchicine", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "astemizole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "rapamycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Fulvestrant", "interaction_type": 73, "interaction_text": "The serum concentration of Fulvestrant can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "PHENPROCOUMON", "interaction_type": 73, "interaction_text": "The serum concentration of PHENPROCOUMON can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "prednisone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "zalcitabine", "interaction_type": 73, "interaction_text": "The serum concentration of zalcitabine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "prednisone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "timolol", "interaction_type": 73, "interaction_text": "The serum concentration of timolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "propafenone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "nimodipine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "equilin", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Pazopanib", "interaction_type": 73, "interaction_text": "The serum concentration of Pazopanib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Dexfenfluramine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "vincristine", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "methylene blue", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "praziquantel", "interaction_type": 73, "interaction_text": "The serum concentration of praziquantel can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "propafenone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "citalopram", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "propafenone", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Imatinib", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Udenafil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Icatibant", "interaction_type": 73, "interaction_text": "The serum concentration of Icatibant can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "temazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Baricitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Baricitinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "cisapride", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "SERATRODAST", "interaction_type": 73, "interaction_text": "The serum concentration of SERATRODAST can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "zaltoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of zaltoprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Aceclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of Aceclofenac can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "cisapride", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "cilostazol", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "ethotoin", "interaction_type": 73, "interaction_text": "The serum concentration of ethotoin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Fosphenytoin", "interaction_type": 73, "interaction_text": "The serum concentration of Fosphenytoin can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Safinamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "citalopram", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "lidocaine", "drug2": "penbutolol", "interaction_type": 73, "interaction_text": "The serum concentration of penbutolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "edrophonium", "interaction_type": 73, "interaction_text": "The serum concentration of edrophonium can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "4-aminopyridine", "drug2": "metformin", "interaction_type": 73, "interaction_text": "The serum concentration of metformin can be increased when it is combined with 4-aminopyridine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zopiclone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "halothane", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "quinidine", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "argatroban", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "albendazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Tramadol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "methadone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "thiotepa", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "sulfasalazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfasalazine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with zolmitriptan.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "praziquantel", "interaction_type": 73, "interaction_text": "The serum concentration of praziquantel can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "pimozide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pimozide", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "indinavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "estrone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "digoxin", "drug2": "suprofen", "interaction_type": 73, "interaction_text": "The serum concentration of suprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 73, "interaction_text": "The serum concentration of TROLAMINE SALICYLATE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Cladribine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Cladribine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "cisapride", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "pimozide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pimozide", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "clopidogrel", "interaction_type": 73, "interaction_text": "The serum concentration of clopidogrel can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Varenicline", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "busulfan", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "cefotetan", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefotetan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "busulfan", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "alosetron", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "alosetron", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Varenicline", "drug2": "ROSOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of ROSOXACIN can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "difluprednate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "methadone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "etizolam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "metoprolol", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "triazolam", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Lumiracoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Lumiracoxib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "pyrazinamide", "interaction_type": 73, "interaction_text": "The serum concentration of pyrazinamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "colchicine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Gatifloxacin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "flunisolide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "glipizide", "interaction_type": 73, "interaction_text": "The serum concentration of glipizide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clonazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clonazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "formoterol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with formoterol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "isoflurane", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with isoflurane.", "severity": 2}
{"drug1": "domperidone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Bendamustine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "imipramine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "acebutolol", "interaction_type": 73, "interaction_text": "The serum concentration of acebutolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Lacidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Lacidipine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "imipramine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "warfarin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "dopamine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "dopamine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "glipizide", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "citalopram", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "carmustine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with carmustine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Icatibant", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Icatibant.", "severity": 2}
{"drug1": "zidovudine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with valsartan.", "severity": 2}
{"drug1": "sertraline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "protriptyline", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "propranolol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "DOXOFYLLINE", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "periciazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "risperidone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "ketamine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "citalopram", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "propafenone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "estriol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with estriol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "diclofenac", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "felbamate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "colchicine", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "meperidine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "digoxin", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "clozapine", "drug2": "Escitalopram", "interaction_type": 73, "interaction_text": "The serum concentration of Escitalopram can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "duloxetine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "azelastine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "testosterone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "topotecan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "toremifene", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "zopiclone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "felodipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "morphine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "mebendazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "methadone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "nadolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "meperidine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "eperisone", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with eperisone.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "busulfan", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Aliskiren", "interaction_type": 73, "interaction_text": "The serum concentration of Aliskiren can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Silodosin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "astemizole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "atenolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flunitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flunitrazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "difluprednate", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "difluprednate", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Glecaprevir", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Glecaprevir.", "severity": 2}
{"drug1": "testosterone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "irinotecan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "estazolam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "domperidone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "cabergoline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "busulfan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "amoxapine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "physostigmine", "interaction_type": 73, "interaction_text": "The serum concentration of physostigmine can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "bezafibrate", "interaction_type": 73, "interaction_text": "The serum concentration of bezafibrate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Yohimbine", "interaction_type": 73, "interaction_text": "The serum concentration of Yohimbine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "digitoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digitoxin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Naftifine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Naftifine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "cisplatin", "interaction_type": 73, "interaction_text": "The serum concentration of cisplatin can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "metoprolol", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "dolasetron", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Axitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Axitinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "theophylline", "interaction_type": 73, "interaction_text": "The serum concentration of theophylline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "colchicine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Brigatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Brigatinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "colchicine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ranitidine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "glyburide", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "quinidine", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "digoxin", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "etodolac", "interaction_type": 73, "interaction_text": "The serum concentration of etodolac can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "flecainide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "thiotepa", "interaction_type": 73, "interaction_text": "The serum concentration of thiotepa can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "lamivudine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with lamivudine.", "severity": 2}
{"drug1": "metolazone", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "midazolam", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with mefenamic acid.", "severity": 2}
{"drug1": "amoxapine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "vincristine", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "PHENYLACETIC ACID", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with PHENYLACETIC ACID.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "alosetron", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "deslanoside", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Valrubicin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with Valrubicin.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "propofol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "temazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "sildenafil", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "polythiazide", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "vincristine", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "pimozide", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "quetiapine", "interaction_type": 73, "interaction_text": "The serum concentration of quetiapine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "etoposide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "lomustine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with lomustine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "digitoxin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "selegiline", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "nadolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "topotecan", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Ezetimibe", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Ezetimibe.", "severity": 2}
{"drug1": "Ezetimibe", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ezetimibe.", "severity": 2}
{"drug1": "Silodosin", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "cocaine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Varenicline", "drug2": "Asenapine", "interaction_type": 73, "interaction_text": "The serum concentration of Asenapine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Lumiracoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Lumiracoxib can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Varenicline", "drug2": "Trovafloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of Trovafloxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with thiothixene.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "mebendazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with NAPROXEN.", "severity": 2}
{"drug1": "cytarabine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "digoxin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "tolmetin", "interaction_type": 73, "interaction_text": "The serum concentration of tolmetin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Estrone sulfate", "interaction_type": 73, "interaction_text": "The serum concentration of Estrone sulfate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "ouabain", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "pravastatin", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Afatinib", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "triazolam", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "albendazole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "clonidine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "colchicine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "naloxone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "enalapril", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "trimipramine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "clonidine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "zonisamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with methylphenidate.", "severity": 2}
{"drug1": "vincristine", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "oxazepam", "interaction_type": 73, "interaction_text": "The serum concentration of oxazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "LEVOBUNOLOL", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with LEVOBUNOLOL.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "sertraline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "methotrexate", "drug2": "penicillin g", "interaction_type": 73, "interaction_text": "The serum concentration of penicillin g can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Imatinib", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ibuprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ibuprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "propafenone", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Letermovir.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "epinastine", "interaction_type": 73, "interaction_text": "The serum concentration of epinastine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tretinoin", "interaction_type": 73, "interaction_text": "The serum concentration of tretinoin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dolasetron", "interaction_type": 73, "interaction_text": "The serum concentration of dolasetron can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clopidogrel", "interaction_type": 73, "interaction_text": "The serum concentration of clopidogrel can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "ouabain", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Sitaxsentan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Sitaxsentan.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "zolpidem", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "citalopram", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "flunisolide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "lithium ion", "drug2": "carprofen", "interaction_type": 73, "interaction_text": "The serum concentration of carprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cinnarizine", "interaction_type": 73, "interaction_text": "The serum concentration of cinnarizine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with tolfenamic acid.", "severity": 2}
{"drug1": "carvedilol", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "cisapride", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "cisapride", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Choline magnesium trisalicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Choline magnesium trisalicylate can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "pentamidine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "halcinonide", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "nicotine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "propafenone", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "cefoxitin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefoxitin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "periciazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "formestane", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "caffeine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "aminophylline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "sildenafil", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "topotecan", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "busulfan", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "budesonide", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Norelgestromin", "interaction_type": 73, "interaction_text": "The serum concentration of Norelgestromin can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with benztropine.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "lithium ion", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Frovatriptan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "vincristine", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "CEFIXIME", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with CEFIXIME.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with tazarotene.", "severity": 2}
{"drug1": "lithium ion", "drug2": "rescinnamine", "interaction_type": 73, "interaction_text": "The serum concentration of rescinnamine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "diazepam", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Venetoclax", "interaction_type": 73, "interaction_text": "The serum concentration of Venetoclax can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "minoxidil", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with minoxidil.", "severity": 2}
{"drug1": "prednisone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "barnidipine", "interaction_type": 73, "interaction_text": "The serum concentration of barnidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Vismodegib", "interaction_type": 73, "interaction_text": "The serum concentration of Vismodegib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "triazolam", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "domperidone", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "ropinirole", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "trazodone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "warfarin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "pravastatin", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "citalopram", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Rotigotine", "interaction_type": 73, "interaction_text": "The serum concentration of Rotigotine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "equilin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "bepridil", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with bepridil.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lornoxicam.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "pravastatin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "Carfilzomib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Carfilzomib.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "glyburide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "medrysone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Quinine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "CARTEOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of CARTEOLOL can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "progesterone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "loperamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "trimipramine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "quetiapine", "interaction_type": 73, "interaction_text": "The serum concentration of quetiapine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "aminophylline", "interaction_type": 73, "interaction_text": "The serum concentration of aminophylline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "codeine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "halothane", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "warfarin", "drug2": "chloral hydrate", "interaction_type": 73, "interaction_text": "The serum concentration of chloral hydrate can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "glipizide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "sulindac", "interaction_type": 73, "interaction_text": "The serum concentration of sulindac can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "topotecan", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ritonavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "ouabain", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "cilostazol", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "glipizide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "galanthamine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Arformoterol.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Arformoterol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "lithium ion", "drug2": "TASOSARTAN", "interaction_type": 73, "interaction_text": "The serum concentration of TASOSARTAN can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "promazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "nadolol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Tapentadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tapentadol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "felbamate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "periciazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "periciazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with mesalamine.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "glipizide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "desipramine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "indinavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "histamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "finasteride", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with nitric oxide.", "severity": 2}
{"drug1": "Encainide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Encainide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "periciazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "busulfan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Yohimbine", "interaction_type": 73, "interaction_text": "The serum concentration of Yohimbine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "nimodipine", "interaction_type": 73, "interaction_text": "The serum concentration of nimodipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "digoxin", "drug2": "meclofenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of meclofenamic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "digoxin", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "loperamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "estazolam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "tiagabine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "indinavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "rosiglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of rosiglitazone can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "pravastatin", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "topotecan", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "donepezil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "felodipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Dienogest", "interaction_type": 73, "interaction_text": "The serum concentration of Dienogest can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "simvastatin", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "galanthamine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "busulfan", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "busulfan", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "busulfan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "quinidine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "miconazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Levonorgestrel", "interaction_type": 73, "interaction_text": "The serum concentration of Levonorgestrel can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "doxepin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "estriol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with estriol.", "severity": 2}
{"drug1": "vincristine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "ADAPALENE", "interaction_type": 73, "interaction_text": "The serum concentration of ADAPALENE can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "colchicine", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "promethazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "MAGNESIUM HYDROXIDE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM HYDROXIDE can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "domperidone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Varenicline", "drug2": "nalidixic acid", "interaction_type": 73, "interaction_text": "The serum concentration of nalidixic acid can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "colchicine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "citalopram", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "citalopram", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "formestane", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "clomipramine", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "simvastatin", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "naloxone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "floctafenine", "interaction_type": 73, "interaction_text": "The serum concentration of floctafenine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "flumethasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "pimozide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "ropinirole", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "amprenavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "midazolam", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Doxercalciferol", "interaction_type": 73, "interaction_text": "The serum concentration of Doxercalciferol can be increased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "clorazepate", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "cisapride", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "digoxin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "zopiclone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "vincristine", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "moclobemide", "interaction_type": 73, "interaction_text": "The serum concentration of moclobemide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with norfloxacin.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "lamivudine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with lamivudine.", "severity": 2}
{"drug1": "indinavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "glyburide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "propafenone", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "indapamide", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Varenicline", "drug2": "ROXATIDINE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of ROXATIDINE ACETATE can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "budesonide", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Riociguat", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "bupropion", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "clofibrate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "pimozide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pimozide", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "cefaclor", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefaclor.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "thiopental", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with thiopental.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "zopiclone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "Apixaban", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "glyburide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "nefazodone", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "indomethacin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with indomethacin.", "severity": 2}
{"drug1": "codeine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "isradipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "loteprednol", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "trazodone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "flutamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "flunitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flunitrazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Elvitegravir", "interaction_type": 73, "interaction_text": "The serum concentration of Elvitegravir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ETOFENAMATE", "interaction_type": 73, "interaction_text": "The serum concentration of ETOFENAMATE can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Melatonin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Melatonin.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Nitrofural.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "diazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "haloperidol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "vindesine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "estazolam", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "CEFPODOXIME", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with CEFPODOXIME.", "severity": 2}
{"drug1": "Norelgestromin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Norelgestromin.", "severity": 2}
{"drug1": "Encainide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Encainide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "BENZYDAMINE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with BENZYDAMINE.", "severity": 2}
{"drug1": "budesonide", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "domperidone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "Varenicline", "drug2": "famotidine", "interaction_type": 73, "interaction_text": "The serum concentration of famotidine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "promazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "imipramine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "ergocalciferol", "interaction_type": 73, "interaction_text": "The serum concentration of ergocalciferol can be increased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "metronidazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "topotecan", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with nitrofurantoin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with actinomycin D.", "severity": 2}
{"drug1": "methotrexate", "drug2": "SERATRODAST", "interaction_type": 73, "interaction_text": "The serum concentration of SERATRODAST can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "alosetron", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "indinavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Frovatriptan.", "severity": 2}
{"drug1": "methotrexate", "drug2": "zaltoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of zaltoprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Aceclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of Aceclofenac can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "pramipexole", "interaction_type": 73, "interaction_text": "The serum concentration of pramipexole can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "diazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "diflorasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "theophylline", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "famciclovir", "interaction_type": 73, "interaction_text": "The serum concentration of famciclovir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "zolpidem", "interaction_type": 73, "interaction_text": "The serum concentration of zolpidem can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "colchicine", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "colchicine", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "arsenic trioxide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with arsenic trioxide.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "irinotecan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "topotecan", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Obeticholic acid", "interaction_type": 73, "interaction_text": "The serum concentration of Obeticholic acid can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "betahistine", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "vincristine", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "disulfiram", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "phenytoin", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "triazolam", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "vinblastine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Levocetirizine", "interaction_type": 73, "interaction_text": "The serum concentration of Levocetirizine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "timolol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "EXEMESTANE", "interaction_type": 73, "interaction_text": "The serum concentration of EXEMESTANE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "astemizole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "vindesine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "DOXOFYLLINE", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "prednisone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "halothane", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "vincristine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "etizolam", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "pimozide", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "clozapine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "vincristine", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "losartan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "vincristine", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "methylene blue", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "azathioprine", "drug2": "Febuxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Febuxostat can be increased when it is combined with azathioprine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "estradiol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "diazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "methotrexate", "drug2": "sulindac", "interaction_type": 73, "interaction_text": "The serum concentration of sulindac can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "diazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "acebutolol", "interaction_type": 73, "interaction_text": "The serum concentration of acebutolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Quinine", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "desipramine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "halcinonide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "midazolam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "alosetron", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "equilin", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "bupropion", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "prochlorperazine", "interaction_type": 73, "interaction_text": "The serum concentration of prochlorperazine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Artemether", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "granisetron", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tolmetin", "interaction_type": 73, "interaction_text": "The serum concentration of tolmetin can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "diltiazem", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Encainide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Encainide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "meclofenamic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with meclofenamic acid.", "severity": 2}
{"drug1": "tinidazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "budesonide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "topotecan", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "topotecan", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "lithium ion", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 73, "interaction_text": "The serum concentration of AZILSARTAN MEDOXOMIL can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "midazolam", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "calcitriol", "interaction_type": 73, "interaction_text": "The serum concentration of calcitriol can be increased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "flurazepam", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "fenofibrate", "interaction_type": 73, "interaction_text": "The serum concentration of fenofibrate can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "etodolac", "interaction_type": 73, "interaction_text": "The serum concentration of etodolac can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "thiamylal", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with thiamylal.", "severity": 2}
{"drug1": "budesonide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "cabergoline", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "etoposide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "mefenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mefenamic acid can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cinoxacin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "prednisone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "letrozole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "clonidine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "cilnidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with cilnidipine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "buspirone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "vincristine", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "6-Mercaptopurine", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with 6-Mercaptopurine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "promazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dolasetron", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with fleroxacin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "methyltestosterone", "interaction_type": 73, "interaction_text": "The serum concentration of methyltestosterone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "digoxin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "celiprolol", "interaction_type": 73, "interaction_text": "The serum concentration of celiprolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "oxazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "alosetron", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "colchicine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "morphine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "trazodone", "interaction_type": 73, "interaction_text": "The serum concentration of trazodone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "glipizide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "modafinil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with OLODATEROL.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "teniposide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "betahistine", "drug2": "moclobemide", "interaction_type": 73, "interaction_text": "The serum concentration of moclobemide can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "medrysone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "medrysone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "sertraline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "amiodarone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "metolazone", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "cilostazol", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "leflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of leflunomide can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Netupitant", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Netupitant.", "severity": 2}
{"drug1": "Netupitant", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Netupitant.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "vincristine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "budesonide", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "quinidine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "colchicine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "docetaxel", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "azlocillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with azlocillin.", "severity": 2}
{"drug1": "desipramine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "diltiazem", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "doxepin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "memantine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "timolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Arotinolol", "interaction_type": 73, "interaction_text": "The serum concentration of Arotinolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "naloxone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Bosentan", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Rosuvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Rosuvastatin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "celecoxib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "topotecan", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "teniposide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "busulfan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "rapamycin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Sodium oxybate", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Sodium oxybate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "felodipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "quazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "simvastatin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "epinastine", "interaction_type": 73, "interaction_text": "The serum concentration of epinastine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "dolasetron", "interaction_type": 73, "interaction_text": "The serum concentration of dolasetron can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "domperidone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "busulfan", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "dapsone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "bepridil", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with bepridil.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Varenicline", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with NORGESTIMATE.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "celiprolol", "interaction_type": 73, "interaction_text": "The serum concentration of celiprolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "cytarabine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "metolazone", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "phenytoin", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "vindesine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "loperamide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "imipramine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "propofol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "cocaine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nimesulide", "interaction_type": 73, "interaction_text": "The serum concentration of nimesulide can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Permethrin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "duloxetine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "docetaxel", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "doxepin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "estrone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "azelastine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "azelastine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "warfarin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "loperamide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "vincristine", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "acemetacin", "drug2": "diflunisal", "interaction_type": 73, "interaction_text": "The serum concentration of diflunisal can be increased when it is combined with acemetacin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Bendamustine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "TASOSARTAN", "interaction_type": 73, "interaction_text": "The serum concentration of TASOSARTAN can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Udenafil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "glyburide", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "methotrexate", "drug2": "suprofen", "interaction_type": 73, "interaction_text": "The serum concentration of suprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Maraviroc", "interaction_type": 73, "interaction_text": "The serum concentration of Maraviroc can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "indapamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sulfaphenazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfaphenazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with maprotiline.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "famotidine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with famotidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "praziquantel", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "alosetron", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "captopril", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with captopril.", "severity": 2}
{"drug1": "dicumarol", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "methadone", "drug2": "letrozole", "interaction_type": 73, "interaction_text": "The serum concentration of letrozole can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Asenapine", "interaction_type": 73, "interaction_text": "The serum concentration of Asenapine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Vernakalant", "interaction_type": 73, "interaction_text": "The serum concentration of Vernakalant can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "cisapride", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Arformoterol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "triazolam", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "colchicine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "colchicine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "metoprolol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "propofol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dorzolamide", "interaction_type": 73, "interaction_text": "The serum concentration of dorzolamide can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "midazolam", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "cisapride", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "proguanil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "methadone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "colchicine", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "thiamylal", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with thiamylal.", "severity": 2}
{"drug1": "caffeine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "caffeine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "ketoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ketoprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "levodopa", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with levodopa.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "timolol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "PIPECURONIUM", "interaction_type": 73, "interaction_text": "The serum concentration of PIPECURONIUM can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "pancuronium", "interaction_type": 73, "interaction_text": "The serum concentration of pancuronium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "deslanoside", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "digoxin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "clozapine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with oxaprozin.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "epinastine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "thioridazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "thiotepa", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "citalopram", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "duloxetine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "propafenone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "indinavir", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "diazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "periciazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Tramadol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "thioridazine", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "imipramine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "vincristine", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "equilin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with GESTODENE.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Prostaglandin E2.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "acebutolol", "interaction_type": 73, "interaction_text": "The serum concentration of acebutolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "glyburide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with moclobemide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "topotecan", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "colchicine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "metrizamide", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with metrizamide.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Lobeglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Lobeglitazone can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with indomethacin.", "severity": 2}
{"drug1": "moclobemide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with moclobemide.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "topotecan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "phenindione", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "metoprolol", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nortriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of nortriptyline can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "colchicine", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "naloxone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "topotecan", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Silodosin", "interaction_type": 73, "interaction_text": "The serum concentration of Silodosin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Prasugrel", "interaction_type": 73, "interaction_text": "The serum concentration of Prasugrel can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "ethanol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "formestane", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "flecainide", "drug2": "Trometamol", "interaction_type": 73, "interaction_text": "The serum concentration of Trometamol can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "praziquantel", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "metolazone", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "propafenone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "propafenone", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "ropinirole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "prazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "citalopram", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "toremifene", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "quazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "carvedilol", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Almotriptan", "interaction_type": 73, "interaction_text": "The serum concentration of Almotriptan can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Paricalcitol", "interaction_type": 73, "interaction_text": "The serum concentration of Paricalcitol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tinidazole", "interaction_type": 73, "interaction_text": "The serum concentration of tinidazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "carvedilol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "doxepin", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "warfarin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "flutamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "tizanidine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "risperidone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Canagliflozin", "interaction_type": 73, "interaction_text": "The serum concentration of Canagliflozin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "medrysone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "medrysone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "pimozide", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "aminophylline", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "indapamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "losartan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Candesartan cilexetil.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "estazolam", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "cilostazol", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Artemether", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "doxepin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Artemether", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "gemcitabine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with gemcitabine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "methotrexate", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "meclofenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of meclofenamic acid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "estradiol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "loratadine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "methotrexate", "drug2": "mycophenolate mofetil", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolate mofetil can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Riociguat", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "thioridazine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "propranolol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "colchicine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "busulfan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "clozapine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "colchicine", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "cisapride", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "cisapride", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "carvedilol", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "oxyphenbutazone", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenbutazone can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "midazolam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with DESOGESTREL.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "pravastatin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "barnidipine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "nicotine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "desipramine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "felbamate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "periciazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "proguanil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "nimodipine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "pramipexole", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with pramipexole.", "severity": 2}
{"drug1": "pimozide", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "nimesulide", "interaction_type": 73, "interaction_text": "The serum concentration of nimesulide can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "ethanol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "meperidine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "digoxin", "drug2": "Icatibant", "interaction_type": 73, "interaction_text": "The serum concentration of Icatibant can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Belinostat", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Belinostat.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "imipramine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "pergolide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "digoxin", "drug2": "SERATRODAST", "interaction_type": 73, "interaction_text": "The serum concentration of SERATRODAST can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "digoxin", "drug2": "zaltoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of zaltoprofen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Aceclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of Aceclofenac can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "mianserin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "medrysone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "dicumarol", "drug2": "chloral hydrate", "interaction_type": 73, "interaction_text": "The serum concentration of chloral hydrate can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Propoxyphene napsylate", "interaction_type": 73, "interaction_text": "The serum concentration of Propoxyphene napsylate can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Eltrombopag.", "severity": 2}
{"drug1": "vincristine", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "vincristine", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "warfarin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Bexarotene", "interaction_type": 73, "interaction_text": "The serum concentration of Bexarotene can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "clofazimine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "colchicine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "etoposide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "colchicine", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "prednisone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "donepezil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pibrentasvir", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Pibrentasvir.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "vincristine", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "citalopram", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "guanabenz", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with guanabenz.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "glipizide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "malathion", "interaction_type": 73, "interaction_text": "The serum concentration of malathion can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "quinidine", "drug2": "cerulenin", "interaction_type": 73, "interaction_text": "The serum concentration of cerulenin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "albendazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "halothane", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "desipramine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "deslanoside", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "histamine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "triazolam", "interaction_type": 73, "interaction_text": "The serum concentration of triazolam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nicotine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "cephaloridine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cephaloridine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "metolazone", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "codeine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "glipizide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "ouabain", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with fluvoxamine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "barnidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "citalopram", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "flutamide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "halothane", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "warfarin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "vincristine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "morphine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "labetalol", "interaction_type": 73, "interaction_text": "The serum concentration of labetalol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "Silodosin", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "diflorasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "citalopram", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Mometasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "piperazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with piperazine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Olopatadine", "interaction_type": 73, "interaction_text": "The serum concentration of Olopatadine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "topotecan", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "modafinil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "pergolide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "busulfan", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "barnidipine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "PARALDEHYDE", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with PARALDEHYDE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nabumetone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "sulfaphenazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfaphenazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "ethanol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Oritavancin", "interaction_type": 73, "interaction_text": "The serum concentration of Oritavancin can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "loteprednol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "enalapril", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "montelukast", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Bismuth subcitrate potassium", "interaction_type": 73, "interaction_text": "The serum concentration of Bismuth subcitrate potassium can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "pyrazinamide", "interaction_type": 73, "interaction_text": "The serum concentration of pyrazinamide can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "topotecan", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "phenindione", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "selegiline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "omeprazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "teniposide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "busulfan", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with mefenamic acid.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "alclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of alclofenac can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Aceclofenac", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Aceclofenac.", "severity": 2}
{"drug1": "cisapride", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clorazepate", "interaction_type": 73, "interaction_text": "The serum concentration of clorazepate can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "nitric oxide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nitric oxide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lenvatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lenvatinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Masoprocol", "interaction_type": 73, "interaction_text": "The serum concentration of Masoprocol can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with rosiglitazone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "colchicine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "Glecaprevir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Glecaprevir.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "vindesine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Salmeterol", "interaction_type": 73, "interaction_text": "The serum concentration of Salmeterol can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "medrysone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "medrysone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "letrozole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "phenindione", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "oxaliplatin", "interaction_type": 73, "interaction_text": "The serum concentration of oxaliplatin can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "vindesine", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "topotecan", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "vincristine", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "topotecan", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "vindesine", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Pregabalin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "progesterone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "Imatinib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "glyburide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Gliquidone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "clonidine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "risperidone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "sotalol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with sotalol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "theophylline", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with UMECLIDINIUM.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with D-mannitol.", "severity": 2}
{"drug1": "Permethrin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "Quinine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "teniposide", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "glyburide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with irbesartan.", "severity": 2}
{"drug1": "miconazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "halcinonide", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "midazolam", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "midazolam", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "clofibrate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "propranolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "alclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of alclofenac can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "mianserin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "Axitinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Axitinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "toremifene", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "alfacalcidol", "interaction_type": 73, "interaction_text": "The serum concentration of alfacalcidol can be increased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "BOPINDOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BOPINDOLOL can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "alosetron", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "vincristine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "desipramine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "propofol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "riluzole", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with riluzole.", "severity": 2}
{"drug1": "albendazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "barnidipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "pimozide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Naloxegol", "interaction_type": 73, "interaction_text": "The serum concentration of Naloxegol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "losartan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "sertraline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "citalopram", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "citalopram", "drug2": "Eslicarbazepine acetate", "interaction_type": 73, "interaction_text": "The serum concentration of Eslicarbazepine acetate can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "dacarbazine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with dacarbazine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "diazepam", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "Afatinib", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "estradiol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "simvastatin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "sotalol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with sotalol.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "practolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "sotalol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with sotalol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "methadone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Neratinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "amcinonide", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with rizatriptan.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "norethindrone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "quinidine", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Neratinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "mequitazine", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "loteprednol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "metolazone", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "methotrexate", "interaction_type": 73, "interaction_text": "The serum concentration of methotrexate can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "prednisone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Afatinib", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "citalopram", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "colchicine", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "estradiol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "domperidone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "formestane", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "vincristine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "vincristine", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "vincristine", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with ranitidine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "loperamide", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "hydroxyurea", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxyurea can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "diclofenac", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "metoprolol", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "Imatinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with sparfloxacin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "methotrexate", "drug2": "CYCLACILLIN", "interaction_type": 73, "interaction_text": "The serum concentration of CYCLACILLIN can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "triamterene", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with triamterene.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ketoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ketoprofen can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "indapamide", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "ESMOLOL", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with ESMOLOL.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "bromazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "practolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "practolol", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "quinidine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "dicumarol", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "doxepin", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "toremifene", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "digoxin", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "zidovudine", "interaction_type": 73, "interaction_text": "The serum concentration of zidovudine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "citalopram", "drug2": "moclobemide", "interaction_type": 73, "interaction_text": "The serum concentration of moclobemide can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "oxazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "indapamide", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flumazenil", "interaction_type": 73, "interaction_text": "The serum concentration of flumazenil can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "IMIQUIMOD", "interaction_type": 73, "interaction_text": "The serum concentration of IMIQUIMOD can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "granisetron", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "midazolam", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tazarotene", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with tazarotene.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "memantine", "interaction_type": 73, "interaction_text": "The serum concentration of memantine can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "citalopram", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "citalopram", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "nateglinide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "vincristine", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "testosterone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "glimepiride", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with glimepiride.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "quazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Darunavir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "tolterodine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "digoxin", "drug2": "ELIGLUSTAT", "interaction_type": 73, "interaction_text": "The serum concentration of ELIGLUSTAT can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "choline", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with choline.", "severity": 2}
{"drug1": "loperamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "Permethrin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with IDARUBICIN.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "cocaine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with cocaine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "budesonide", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "sildenafil", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "tetracycline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Silodosin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "busulfan", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "toremifene", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "lidocaine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "topotecan", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with IDARUBICIN.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "hydroxyurea", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxyurea can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "epinastine", "interaction_type": 73, "interaction_text": "The serum concentration of epinastine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tavaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Tavaborole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dolasetron", "interaction_type": 73, "interaction_text": "The serum concentration of dolasetron can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Pimecrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Pimecrolimus can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "polythiazide", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "promazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Remoxipride.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "Perospirone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "dexlansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of dexlansoprazole can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Mepyramine", "interaction_type": 73, "interaction_text": "The serum concentration of Mepyramine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "rapamycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "simvastatin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "vincristine", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "topotecan", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "estrone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "estramustine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Frovatriptan", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with Frovatriptan.", "severity": 2}
{"drug1": "omeprazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "dapsone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "topotecan", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "colchicine", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "rasagiline", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with rasagiline.", "severity": 2}
{"drug1": "celiprolol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "xylometazoline", "interaction_type": 73, "interaction_text": "The serum concentration of xylometazoline can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tolfenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tolfenamic acid can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "irinotecan", "interaction_type": 73, "interaction_text": "The serum concentration of irinotecan can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "warfarin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "cilostazol", "drug2": "topiramate", "interaction_type": 73, "interaction_text": "The serum concentration of topiramate can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with zolmitriptan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "pramipexole", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with pramipexole.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "metolazone", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Belinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Belinostat can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "triazolam", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "glyburide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "warfarin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "mestranol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mestranol.", "severity": 2}
{"drug1": "proguanil", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "phenytoin", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "galanthamine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with galanthamine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "ethanol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dexfenfluramine.", "severity": 2}
{"drug1": "doxepin", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "oxaprozin", "interaction_type": 73, "interaction_text": "The serum concentration of oxaprozin can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "oxyphenbutazone", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenbutazone can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "estazolam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Riociguat", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with APRINDINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "temazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "cisapride", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Torasemide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Torasemide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "felbamate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dextroamphetamine", "interaction_type": 73, "interaction_text": "The serum concentration of dextroamphetamine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "METHAMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of METHAMPHETAMINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "morphine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "modafinil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Masoprocol", "interaction_type": 73, "interaction_text": "The serum concentration of Masoprocol can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "morphine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Vandetanib", "interaction_type": 73, "interaction_text": "The serum concentration of Vandetanib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "diazepam", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "buspirone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "digoxin", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "clonazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "budesonide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "rasagiline", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with rasagiline.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "nabumetone", "interaction_type": 73, "interaction_text": "The serum concentration of nabumetone can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "ketorolac", "interaction_type": 73, "interaction_text": "The serum concentration of ketorolac can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "quazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "caffeine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with metoclopramide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "clozapine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "albendazole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "imipramine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "doxepin", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "penbutolol", "interaction_type": 73, "interaction_text": "The serum concentration of penbutolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "irinotecan", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "enalapril", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "caffeine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "etoposide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "quinacrine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "losartan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "triazolam", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "simvastatin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Riociguat", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "simvastatin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "sotalol", "interaction_type": 73, "interaction_text": "The serum concentration of sotalol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Gliquidone.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "primidone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with primidone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "trazodone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "topotecan", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "topotecan", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "gabapentin", "interaction_type": 73, "interaction_text": "The serum concentration of gabapentin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ethosuximide", "interaction_type": 73, "interaction_text": "The serum concentration of ethosuximide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Letermovir.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Letermovir.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Escitalopram", "interaction_type": 73, "interaction_text": "The serum concentration of Escitalopram can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "podophyllotoxin", "interaction_type": 73, "interaction_text": "The serum concentration of podophyllotoxin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Cidofovir", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Cidofovir.", "severity": 2}
{"drug1": "cilostazol", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with sumatriptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "vindesine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "PIRFENIDONE", "interaction_type": 73, "interaction_text": "The serum concentration of PIRFENIDONE can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "lorazepam", "interaction_type": 73, "interaction_text": "The serum concentration of lorazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "metolazone", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Iloperidone", "interaction_type": 73, "interaction_text": "The serum concentration of Iloperidone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "prazepam", "interaction_type": 73, "interaction_text": "The serum concentration of prazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pregabalin", "interaction_type": 73, "interaction_text": "The serum concentration of Pregabalin can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "temazepam", "interaction_type": 73, "interaction_text": "The serum concentration of temazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Apremilast", "interaction_type": 73, "interaction_text": "The serum concentration of Apremilast can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Nepafenac", "interaction_type": 73, "interaction_text": "The serum concentration of Nepafenac can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "formestane", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "citalopram", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "sertraline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "ondansetron", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "propofol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "colchicine", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "glimepiride", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with glimepiride.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "vincristine", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "letrozole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "vincristine", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "doxepin", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "vincristine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Debrisoquine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "cisapride", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "netilmicin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with netilmicin.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "propofol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "GESTODENE", "interaction_type": 73, "interaction_text": "The serum concentration of GESTODENE can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "isradipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Apremilast", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "labetalol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "diphenhydramine", "interaction_type": 73, "interaction_text": "The serum concentration of diphenhydramine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "modafinil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "bupropion", "drug2": "thiotepa", "interaction_type": 73, "interaction_text": "The serum concentration of thiotepa can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "CARTEOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of CARTEOLOL can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "propafenone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "zopiclone", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "practolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with NAPROXEN.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "betahistine", "drug2": "isocarboxazid", "interaction_type": 73, "interaction_text": "The serum concentration of isocarboxazid can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "NORGESTIMATE", "interaction_type": 73, "interaction_text": "The serum concentration of NORGESTIMATE can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "lithium ion", "drug2": "etodolac", "interaction_type": 73, "interaction_text": "The serum concentration of etodolac can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with tolperisone.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Clofarabine.", "severity": 2}
{"drug1": "histamine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "oxazepam", "interaction_type": 73, "interaction_text": "The serum concentration of oxazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "practolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Afatinib", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "busulfan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with dextroamphetamine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "pravastatin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "IDARUBICIN", "interaction_type": 73, "interaction_text": "The serum concentration of IDARUBICIN can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "gliclazide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with gliclazide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Escitalopram", "interaction_type": 73, "interaction_text": "The serum concentration of Escitalopram can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "zonisamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "vindesine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "epinastine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "ketamine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "estazolam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "alclometasone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "loratadine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "medrysone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "estradiol", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "vindesine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "topotecan", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "Remoxipride", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Remoxipride.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "triazolam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "amoxapine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "thiothixene", "interaction_type": 73, "interaction_text": "The serum concentration of thiothixene can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "tretinoin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "warfarin", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "warfarin", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "vindesine", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "halothane", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Risedronic acid", "interaction_type": 73, "interaction_text": "The serum concentration of Risedronic acid can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Amrinone", "interaction_type": 73, "interaction_text": "The serum concentration of Amrinone can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "indapamide", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "metolazone", "drug2": "ipratropium", "interaction_type": 73, "interaction_text": "The serum concentration of ipratropium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "midazolam", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "buspirone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "risperidone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "quinidine", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "chloramphenicol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with chloramphenicol.", "severity": 2}
{"drug1": "metolazone", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "4-aminopyridine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with 4-aminopyridine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "mycophenolate mofetil", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolate mofetil can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "methylene blue", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "flurazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "aminophylline", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "domperidone", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Apremilast", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "estazolam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "pimozide", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "flutamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "norgestrel", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "equilin", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "proguanil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "lovastatin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "praziquantel", "interaction_type": 73, "interaction_text": "The serum concentration of praziquantel can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "practolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with practolol.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "carboplatin", "interaction_type": 73, "interaction_text": "The serum concentration of carboplatin can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Vinflunine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Vinflunine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "nateglinide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "clorazepate", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "estazolam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cisapride", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "lovastatin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "dicumarol", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "proguanil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "trazodone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "methadone", "drug2": "aminoglutethimide", "interaction_type": 73, "interaction_text": "The serum concentration of aminoglutethimide can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "halcinonide", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "pimozide", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "digoxin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "thiotepa", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "promethazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Lumiracoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Lumiracoxib can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "topotecan", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "granisetron", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "promazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "topotecan", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "busulfan", "drug2": "Propacetamol", "interaction_type": 73, "interaction_text": "The serum concentration of Propacetamol can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "famciclovir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "clemastine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with clemastine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "raloxifene", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "mycophenolic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolic acid can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "lorazepam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with lorazepam.", "severity": 2}
{"drug1": "promethazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "imipramine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "budesonide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with Spectinomycin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "celiprolol", "interaction_type": 73, "interaction_text": "The serum concentration of celiprolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "theophylline", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "topotecan", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "codeine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Camazepam", "interaction_type": 73, "interaction_text": "The serum concentration of Camazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Gadoxetic acid", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Gadoxetic acid.", "severity": 2}
{"drug1": "Axitinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "trazodone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "dicyclomine", "interaction_type": 73, "interaction_text": "The serum concentration of dicyclomine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "tropicamide", "interaction_type": 73, "interaction_text": "The serum concentration of tropicamide can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "digoxin", "drug2": "spiramycin", "interaction_type": 73, "interaction_text": "The serum concentration of spiramycin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "sulfadiazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfadiazine can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "phenytoin", "drug2": "halothane", "interaction_type": 73, "interaction_text": "The serum concentration of halothane can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "donepezil", "interaction_type": 73, "interaction_text": "The serum concentration of donepezil can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "flunisolide", "interaction_type": 73, "interaction_text": "The serum concentration of flunisolide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Cevimeline", "interaction_type": 73, "interaction_text": "The serum concentration of Cevimeline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nicotine", "interaction_type": 73, "interaction_text": "The serum concentration of nicotine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "azelastine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "diclofenac", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "codeine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "etizolam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "midazolam", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "desipramine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "digoxin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "digoxin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "propafenone", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with DESOGESTREL.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cisapride", "interaction_type": 73, "interaction_text": "The serum concentration of cisapride can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Medroxyprogesterone acetate", "interaction_type": 73, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "estazolam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "cephapirin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cephapirin.", "severity": 2}
{"drug1": "deslanoside", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "chloroquine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "selegiline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with nitrofurantoin.", "severity": 2}
{"drug1": "montelukast", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "triazolam", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "proguanil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "argatroban", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "nicotine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "alprazolam", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Tramadol", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "periciazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "methotrexate", "drug2": "SULBACTAM", "interaction_type": 73, "interaction_text": "The serum concentration of SULBACTAM can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ertapenem", "interaction_type": 73, "interaction_text": "The serum concentration of Ertapenem can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Neratinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "desipramine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "desipramine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "methylene blue", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with fluvoxamine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with cholic acid.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "nilutamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nilutamide.", "severity": 2}
{"drug1": "cabergoline", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "phenytoin", "drug2": "etizolam", "interaction_type": 73, "interaction_text": "The serum concentration of etizolam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "topiramate", "interaction_type": 73, "interaction_text": "The serum concentration of topiramate can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Olmesartan", "interaction_type": 73, "interaction_text": "The serum concentration of Olmesartan can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "promazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Prostaglandin E2", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Prostaglandin E2.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "topotecan", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "granisetron", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Apixaban", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "aspirin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "glipizide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "polythiazide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "topotecan", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "azelastine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "ketamine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "colchicine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "metformin", "drug2": "Vandetanib", "interaction_type": 73, "interaction_text": "The serum concentration of Vandetanib can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "caffeine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "ambenonium", "interaction_type": 73, "interaction_text": "The serum concentration of ambenonium can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "nicardipine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "busulfan", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "citalopram", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "domperidone", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "imipramine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "astemizole", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "propafenone", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "prazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "metolazone", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "epinastine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "calcitriol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "equilin", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "equilin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "colchicine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Perampanel", "interaction_type": 73, "interaction_text": "The serum concentration of Perampanel can be increased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Doripenem", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Doripenem.", "severity": 2}
{"drug1": "meperidine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "amoxapine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "ethanol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "vincristine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "pimozide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "methylene blue", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "metoprolol", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Pioglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of Pioglitazone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "carbamazepine", "interaction_type": 73, "interaction_text": "The serum concentration of carbamazepine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "colchicine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "quinidine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "loperamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "ganciclovir", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ganciclovir.", "severity": 2}
{"drug1": "erythromycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with deslanoside.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Vecuronium.", "severity": 2}
{"drug1": "clonidine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Valbenazine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Valbenazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "propafenone", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "propafenone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "selegiline", "drug2": "Estrone sulfate", "interaction_type": 73, "interaction_text": "The serum concentration of Estrone sulfate can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with rizatriptan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "zidovudine", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "buspirone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Avanafil", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "lovastatin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clarithromycin.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Cladribine", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Cladribine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "alprazolam", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "vincristine", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "colchicine", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "diazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "histamine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "busulfan", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "loperamide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "desipramine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "desipramine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with methyprylon.", "severity": 2}
{"drug1": "ceritinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "etoposide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "epinastine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "tolmetin", "interaction_type": 73, "interaction_text": "The serum concentration of tolmetin can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "lidocaine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "captopril", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with captopril.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "nadolol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nadolol.", "severity": 2}
{"drug1": "topotecan", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "moclobemide", "interaction_type": 73, "interaction_text": "The serum concentration of moclobemide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "NAPROXEN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with NAPROXEN.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "temazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "loteprednol", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "ethanol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "ethanol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "budesonide", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "aspirin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with aspirin.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "warfarin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "vindesine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with methyprylon.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "busulfan", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "glyburide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lumiracoxib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "donepezil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "simvastatin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "busulfan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "aminophylline", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "BISOPROLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BISOPROLOL can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "metformin", "drug2": "Dolutegravir", "interaction_type": 73, "interaction_text": "The serum concentration of Dolutegravir can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "colchicine", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "progesterone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "ouabain", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "astemizole", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "domperidone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "phenindione", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "colchicine", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "clonidine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "colchicine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "triazolam", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "norgestrel", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "carvedilol", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "phenoxybenzamine", "interaction_type": 73, "interaction_text": "The serum concentration of phenoxybenzamine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "cyclobenzaprine", "interaction_type": 73, "interaction_text": "The serum concentration of cyclobenzaprine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Penicillin G benzathine", "interaction_type": 73, "interaction_text": "The serum concentration of Penicillin G benzathine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "morphine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Erlotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Erlotinib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "sulindac", "interaction_type": 73, "interaction_text": "The serum concentration of sulindac can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "citalopram", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "prednisone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "clomipramine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "colchicine", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with mefenamic acid.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "quazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "warfarin", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "equilin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "propafenone", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "praziquantel", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Avanafil", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "choline", "interaction_type": 73, "interaction_text": "The serum concentration of choline can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "diclofenac", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "alosetron", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "meperidine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "estrone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "warfarin", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Vandetanib", "interaction_type": 73, "interaction_text": "The serum concentration of Vandetanib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "vincristine", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "formoterol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with formoterol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "formoterol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with formoterol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "tiagabine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "domperidone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "alosetron", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "cisapride", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "cisapride", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "tretinoin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "fenofibrate", "interaction_type": 73, "interaction_text": "The serum concentration of fenofibrate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "BUPRANOLOL", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with BUPRANOLOL.", "severity": 2}
{"drug1": "docetaxel", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Silodosin", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "alosetron", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "medrysone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "naloxone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "nefazodone", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with mifepristone.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "finasteride", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "carmustine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with carmustine.", "severity": 2}
{"drug1": "atenolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Apremilast", "interaction_type": 73, "interaction_text": "The serum concentration of Apremilast can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Masoprocol", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Masoprocol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Quinine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "SUFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of SUFENTANIL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "periciazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "estrone", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "estrone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "resveratrol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with resveratrol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "gliclazide", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with gliclazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "tolperisone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with tolperisone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "testosterone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "flunisolide", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pinaverium", "interaction_type": 73, "interaction_text": "The serum concentration of Pinaverium can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Ambrisentan", "interaction_type": 73, "interaction_text": "The serum concentration of Ambrisentan can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "theophylline", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "loperamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "caffeine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Bendamustine.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "vincristine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with amsacrine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "doxepin", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "sulfadiazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfadiazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "alprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of alprenolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "mycophenolate mofetil", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolate mofetil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "warfarin", "interaction_type": 73, "interaction_text": "The serum concentration of warfarin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "colchicine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Udenafil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ampicillin", "interaction_type": 73, "interaction_text": "The serum concentration of ampicillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "penicillin v", "interaction_type": 73, "interaction_text": "The serum concentration of penicillin v can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "vincristine", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Carfilzomib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Carfilzomib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with doxazosin.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "triazolam", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "budesonide", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "bromazepam", "interaction_type": 73, "interaction_text": "The serum concentration of bromazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "DIHYDROCODEINE", "interaction_type": 73, "interaction_text": "The serum concentration of DIHYDROCODEINE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "tiaprofenic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with tiaprofenic acid.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of 4-PHENYLBUTYRIC ACID can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "benzyl alcohol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with benzyl alcohol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "granisetron", "interaction_type": 73, "interaction_text": "The serum concentration of granisetron can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "astemizole", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "quinidine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Vecuronium", "interaction_type": 73, "interaction_text": "The serum concentration of Vecuronium can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "tolazamide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with tolazamide.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "cefamandole", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefamandole.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "prednisone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "prednisone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Artemether", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "tenoxicam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with tenoxicam.", "severity": 2}
{"drug1": "mianserin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Choline magnesium trisalicylate can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "polythiazide", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "praziquantel", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Butoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Butoconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "methotrexate", "interaction_type": 73, "interaction_text": "The serum concentration of methotrexate can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "diazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "risperidone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "rosiglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of rosiglitazone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "propafenone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "zopiclone", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "topotecan", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "histamine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with histamine.", "severity": 2}
{"drug1": "selegiline", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Apixaban", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "argatroban", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "quazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "promethazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with promethazine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "budesonide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "tretinoin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "cabergoline", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "vindesine", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "busulfan", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "topotecan", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "dapsone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "topotecan", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "norethindrone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "zaleplon", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "clofazimine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "astemizole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "digoxin", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "phenytoin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 73, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "nimodipine", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Deutetrabenazine", "interaction_type": 73, "interaction_text": "The serum concentration of Deutetrabenazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "quinidine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "carvedilol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Dolutegravir", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Dolutegravir.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "vindesine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lornoxicam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Lornoxicam.", "severity": 2}
{"drug1": "alclometasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "estazolam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "estazolam", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "tolbutamide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tolbutamide.", "severity": 2}
{"drug1": "vindesine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Lumiracoxib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Lumiracoxib.", "severity": 2}
{"drug1": "phenindione", "drug2": "ETHACRYNIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of ETHACRYNIC ACID can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "colchicine", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "vincristine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "indapamide", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "indapamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "foscarnet", "drug2": "ETHACRYNIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of ETHACRYNIC ACID can be increased when it is combined with foscarnet.", "severity": 2}
{"drug1": "citalopram", "drug2": "Armodafinil", "interaction_type": 73, "interaction_text": "The serum concentration of Armodafinil can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ropinirole", "interaction_type": 73, "interaction_text": "The serum concentration of ropinirole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "colchicine", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "alosetron", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "kanamycin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with kanamycin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "quinidine", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "prednisone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "quinidine", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "pergolide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "perphenazine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "selegiline", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "midazolam", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Debrisoquine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Debrisoquine.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with anagrelide.", "severity": 2}
{"drug1": "piperazine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with piperazine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Nepafenac", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Nepafenac.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "etodolac", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with etodolac.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Telithromycin.", "severity": 2}
{"drug1": "metolazone", "drug2": "hyoscyamine", "interaction_type": 73, "interaction_text": "The serum concentration of hyoscyamine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "DOXOFYLLINE", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with DOXOFYLLINE.", "severity": 2}
{"drug1": "quinidine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "estazolam", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "ropinirole", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "mianserin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "Rupatadine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Rupatadine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "indinavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "memantine", "drug2": "Magnesium trisilicate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium trisilicate can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "alprenolol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Nepafenac", "interaction_type": 73, "interaction_text": "The serum concentration of Nepafenac can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "manidipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with manidipine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dexlansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of dexlansoprazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "felbamate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "raloxifene", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with raloxifene.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "tolterodine", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Perampanel", "interaction_type": 73, "interaction_text": "The serum concentration of Perampanel can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "antipyrine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "citalopram", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "EFINACONAZOLE", "interaction_type": 73, "interaction_text": "The serum concentration of EFINACONAZOLE can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "clorazepate", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Ezetimibe", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Ezetimibe.", "severity": 2}
{"drug1": "sotalol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with sotalol.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "TRIMETHAPHAN", "interaction_type": 73, "interaction_text": "The serum concentration of TRIMETHAPHAN can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "pimozide", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "thioridazine", "drug2": "labetalol", "interaction_type": 73, "interaction_text": "The serum concentration of labetalol can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "selegiline", "drug2": "ETONOGESTREL", "interaction_type": 73, "interaction_text": "The serum concentration of ETONOGESTREL can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "cisplatin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with cisplatin.", "severity": 2}
{"drug1": "cisplatin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with cisplatin.", "severity": 2}
{"drug1": "labetalol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "loperamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Tapentadol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cisapride", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Neratinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Neratinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "efavirenz", "interaction_type": 73, "interaction_text": "The serum concentration of efavirenz can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nicotinic acid", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinic acid can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "selegiline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "budesonide", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with PROCAINAMIDE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Tapentadol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nicotinamide", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinamide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "glipizide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "benztropine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with benztropine.", "severity": 2}
{"drug1": "topotecan", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "mequitazine", "interaction_type": 73, "interaction_text": "The serum concentration of mequitazine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Asenapine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "topotecan", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "midazolam", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "progesterone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "digoxin", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "theophylline", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "clindamycin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "promazine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "propylthiouracil", "interaction_type": 73, "interaction_text": "The serum concentration of propylthiouracil can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "phenytoin", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "hesperetin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with hesperetin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with diltiazem.", "severity": 2}
{"drug1": "bromazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "miconazole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "acebutolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "formestane", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "warfarin", "drug2": "Torasemide", "interaction_type": 73, "interaction_text": "The serum concentration of Torasemide can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "doxepin", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "vincristine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 73, "interaction_text": "The serum concentration of GALLAMINE TRIETHIODIDE can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "diphenhydramine", "interaction_type": 73, "interaction_text": "The serum concentration of diphenhydramine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "PERHEXILINE", "interaction_type": 73, "interaction_text": "The serum concentration of PERHEXILINE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "tizanidine", "drug2": "pentoxifylline", "interaction_type": 73, "interaction_text": "The serum concentration of pentoxifylline can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "colchicine", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "quinidine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "quinidine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "temazepam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "cisapride", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "streptozocin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with streptozocin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "ergocalciferol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ergocalciferol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "clonazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with bicalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with trifluoperazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "propafenone", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "temazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "citalopram", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "colchicine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nicergoline.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "flurazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "doxepin", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "spiramycin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with NORGESTIMATE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "midazolam", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Naloxegol", "interaction_type": 73, "interaction_text": "The serum concentration of Naloxegol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "medrysone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "montelukast", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "metoprolol", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "glimepiride", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with glimepiride.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "oxprenolol", "interaction_type": 73, "interaction_text": "The serum concentration of oxprenolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "memantine", "drug2": "CALCIUM CARBONATE", "interaction_type": 73, "interaction_text": "The serum concentration of CALCIUM CARBONATE can be increased when it is combined with memantine.", "severity": 2}
{"drug1": "Iloperidone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Iloperidone.", "severity": 2}
{"drug1": "warfarin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "estrone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Vernakalant.", "severity": 2}
{"drug1": "citalopram", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "captopril", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with captopril.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with OLODATEROL.", "severity": 2}
{"drug1": "quinidine", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "digoxin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "desipramine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "desipramine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Silodosin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "acebutolol", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "nimodipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "eperisone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with eperisone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "budesonide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Treprostinil.", "severity": 2}
{"drug1": "Nitrofural", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Nitrofural.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "thioridazine", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "betaxolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "busulfan", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "zonisamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "didanosine", "drug2": "Febuxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Febuxostat can be increased when it is combined with didanosine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "Delafloxacin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Delafloxacin.", "severity": 2}
{"drug1": "methyltestosterone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with methyltestosterone.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with rizatriptan.", "severity": 2}
{"drug1": "methadone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "glyburide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "nimodipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with mequitazine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "alosetron", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "clofazimine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clofazimine.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "methadone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "ETOFENAMATE", "interaction_type": 73, "interaction_text": "The serum concentration of ETOFENAMATE can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "simvastatin", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "fenbufen", "interaction_type": 73, "interaction_text": "The serum concentration of fenbufen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "simvastatin", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "triazolam", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "flunisolide", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "triazolam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "triazolam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "quinidine", "drug2": "haloprogin", "interaction_type": 73, "interaction_text": "The serum concentration of haloprogin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "diflorasone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "alprazolam", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "warfarin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "trazodone", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Nepafenac", "interaction_type": 73, "interaction_text": "The serum concentration of Nepafenac can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "etizolam", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "busulfan", "interaction_type": 73, "interaction_text": "The serum concentration of busulfan can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "etizolam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Levobupivacaine", "interaction_type": 73, "interaction_text": "The serum concentration of Levobupivacaine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "DEXMEDETOMIDINE", "interaction_type": 73, "interaction_text": "The serum concentration of DEXMEDETOMIDINE can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "labetalol", "interaction_type": 73, "interaction_text": "The serum concentration of labetalol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with NORGESTIMATE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "colchicine", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "triazolam", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Varenicline", "drug2": "nizatidine", "interaction_type": 73, "interaction_text": "The serum concentration of nizatidine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "PERHEXILINE", "interaction_type": 73, "interaction_text": "The serum concentration of PERHEXILINE can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with mefenamic acid.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Imatinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "Macitentan", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "niflumic acid", "interaction_type": 73, "interaction_text": "The serum concentration of niflumic acid can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "succinylcholine", "drug2": "metoclopramide", "interaction_type": 73, "interaction_text": "The serum concentration of metoclopramide can be increased when it is combined with succinylcholine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Clevidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Clevidipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "cilostazol", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metolazone", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with nalidixic acid.", "severity": 2}
{"drug1": "phenytoin", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "donepezil", "interaction_type": 73, "interaction_text": "The serum concentration of donepezil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "temazepam", "interaction_type": 73, "interaction_text": "The serum concentration of temazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pregabalin", "interaction_type": 73, "interaction_text": "The serum concentration of Pregabalin can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "tolazamide", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with tolazamide.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "CYPROTERONE ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of CYPROTERONE ACETATE can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "triazolam", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Dexmethylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of Dexmethylphenidate can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "estazolam", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "clomipramine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "betamethasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "ondansetron", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "propofol", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "proguanil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "vincristine", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "risperidone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "bupropion", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Capsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Capsaicin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "polythiazide", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "zolpidem", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "colchicine", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "morphine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "vincristine", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "propranolol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "betamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of betamethasone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with norepinephrine.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ledipasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ledipasvir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "temazepam", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "terazosin", "interaction_type": 73, "interaction_text": "The serum concentration of terazosin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "colchicine", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "letrozole", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with letrozole.", "severity": 2}
{"drug1": "diazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "trimipramine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "atenolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Olsalazine", "interaction_type": 73, "interaction_text": "The serum concentration of Olsalazine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "bromazepam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "ouabain", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "citalopram", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "irinotecan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "zidovudine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Anidulafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Anidulafungin can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "Avanafil", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "4-aminopyridine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with 4-aminopyridine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "cisapride", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "alclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of alclofenac can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "lomustine", "interaction_type": 73, "interaction_text": "The serum concentration of lomustine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "estramustine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with estramustine.", "severity": 2}
{"drug1": "paramethasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "methadone", "drug2": "EXEMESTANE", "interaction_type": 73, "interaction_text": "The serum concentration of EXEMESTANE can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "phenindione", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "cisapride", "drug2": "oxiconazole", "interaction_type": 73, "interaction_text": "The serum concentration of oxiconazole can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Riociguat", "interaction_type": 73, "interaction_text": "The serum concentration of Riociguat can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Macitentan", "interaction_type": 73, "interaction_text": "The serum concentration of Macitentan can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "pravastatin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Apixaban", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "thioridazine", "interaction_type": 73, "interaction_text": "The serum concentration of thioridazine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "digoxin", "drug2": "oxaprozin", "interaction_type": 73, "interaction_text": "The serum concentration of oxaprozin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Silodosin", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "Arotinolol", "interaction_type": 73, "interaction_text": "The serum concentration of Arotinolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "clozapine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "montelukast", "interaction_type": 73, "interaction_text": "The serum concentration of montelukast can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clonazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clonazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "chloramphenicol", "interaction_type": 73, "interaction_text": "The serum concentration of chloramphenicol can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "tiagabine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "erythromycin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "theophylline", "interaction_type": 73, "interaction_text": "The serum concentration of theophylline can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "AMILORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMILORIDE can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "irinotecan", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Icatibant", "interaction_type": 73, "interaction_text": "The serum concentration of Icatibant can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "theophylline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "tizanidine", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "caffeine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "flumethasone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Perospirone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "digitoxin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "tiagabine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "sibutramine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Elbasvir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Elbasvir.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "phenytoin", "interaction_type": 73, "interaction_text": "The serum concentration of phenytoin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "topotecan", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "colchicine", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "atenolol", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "felbamate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with felbamate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "digoxin", "drug2": "Olopatadine", "interaction_type": 73, "interaction_text": "The serum concentration of Olopatadine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "penbutolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "ambroxol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bromazepam", "interaction_type": 73, "interaction_text": "The serum concentration of bromazepam can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "nicotine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "quinidine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "triazolam", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "propafenone", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "sertraline", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "alosetron", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "prednisone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with tolfenamic acid.", "severity": 2}
{"drug1": "colchicine", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "clozapine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "warfarin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Trospium", "interaction_type": 73, "interaction_text": "The serum concentration of Trospium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "zopiclone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "vincristine", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "alprazolam", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "vincristine", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pimozide", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "vincristine", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "flutamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "proguanil", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "propranolol", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "albendazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "quinidine", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tolfenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tolfenamic acid can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "Quinine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Tramadol", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "acebutolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "tubocurarine", "interaction_type": 73, "interaction_text": "The serum concentration of tubocurarine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "simvastatin", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "benztropine", "interaction_type": 73, "interaction_text": "The serum concentration of benztropine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "lithium ion", "drug2": "sulfasalazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfasalazine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "glimepiride", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with glimepiride.", "severity": 2}
{"drug1": "mefloquine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with CARTEOLOL.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "bupropion", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "mebendazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Silodosin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "Palbociclib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Palbociclib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Vismodegib", "interaction_type": 73, "interaction_text": "The serum concentration of Vismodegib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "nefazodone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "topotecan", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "granisetron", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "budesonide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Diacerein", "interaction_type": 73, "interaction_text": "The serum concentration of Diacerein can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "selegiline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "proguanil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "colchicine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "busulfan", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "bupropion", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with bupropion.", "severity": 2}
{"drug1": "tolterodine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "midazolam", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "sulindac", "interaction_type": 73, "interaction_text": "The serum concentration of sulindac can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "nimodipine", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "trazodone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "loratadine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "polythiazide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "fenbufen", "interaction_type": 73, "interaction_text": "The serum concentration of fenbufen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "ETOFENAMATE", "interaction_type": 73, "interaction_text": "The serum concentration of ETOFENAMATE can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "menadione", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with menadione.", "severity": 2}
{"drug1": "imipramine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "equilin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "vincristine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "enalapril", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "leflunomide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with leflunomide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Asenapine", "interaction_type": 73, "interaction_text": "The serum concentration of Asenapine can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "mianserin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "digoxin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "vincristine", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "indapamide", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "mycophenolic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolic acid can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Imatinib", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "indapamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "eperisone", "interaction_type": 73, "interaction_text": "The serum concentration of eperisone can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "indomethacin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with indomethacin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Flucloxacillin", "interaction_type": 73, "interaction_text": "The serum concentration of Flucloxacillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "alosetron", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "digoxin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "propafenone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with betaxolol.", "severity": 2}
{"drug1": "quinidine", "drug2": "griseofulvin", "interaction_type": 73, "interaction_text": "The serum concentration of griseofulvin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Sertaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Sertaconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "colchicine", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "vindesine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "apomorphine", "interaction_type": 73, "interaction_text": "The serum concentration of apomorphine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "citalopram", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "astemizole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "clozapine", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "citalopram", "drug2": "topiramate", "interaction_type": 73, "interaction_text": "The serum concentration of topiramate can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "cimetidine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with cimetidine.", "severity": 2}
{"drug1": "astemizole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "alosetron", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "niflumic acid", "interaction_type": 73, "interaction_text": "The serum concentration of niflumic acid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "epinephrine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with epinephrine.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tofisopam", "interaction_type": 73, "interaction_text": "The serum concentration of tofisopam can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Lurasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Lurasidone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "argatroban", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with chloroquine.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "disulfiram", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "ondansetron", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "clorazepate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "selegiline", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "bifonazole", "interaction_type": 73, "interaction_text": "The serum concentration of bifonazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "dyphylline", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "vincristine", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "vincristine", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "BISOPROLOL", "interaction_type": 73, "interaction_text": "The serum concentration of BISOPROLOL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "KETAZOLAM", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with KETAZOLAM.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "dopamine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "vincristine", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "ceftizoxime", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ceftizoxime.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Flupentixol", "interaction_type": 73, "interaction_text": "The serum concentration of Flupentixol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "propofol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "quinidine", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "citalopram", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "quinidine", "drug2": "trimetrexate", "interaction_type": 73, "interaction_text": "The serum concentration of trimetrexate can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "sulfadiazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfadiazine can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "barnidipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "barnidipine", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with barnidipine.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "allopurinol", "interaction_type": 73, "interaction_text": "The serum concentration of allopurinol can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "clonazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with clonazepam.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "estrone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "budesonide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "benztropine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with benztropine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Droxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Droxicam can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "difluprednate", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "Loxoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of Loxoprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "topotecan", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "CLONIXIN", "interaction_type": 73, "interaction_text": "The serum concentration of CLONIXIN can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Afatinib", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "azithromycin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "terbinafine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "quinidine", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "clopidogrel", "interaction_type": 73, "interaction_text": "The serum concentration of clopidogrel can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "metolazone", "drug2": "Butylscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of Butylscopolamine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Olsalazine.", "severity": 2}
{"drug1": "cisapride", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "GESTODENE", "interaction_type": 73, "interaction_text": "The serum concentration of GESTODENE can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "topotecan", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "trazodone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "trazodone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Riociguat", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with irbesartan.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "antipyrine", "interaction_type": 73, "interaction_text": "The serum concentration of antipyrine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "budesonide", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "promazine", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "methadone", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "epoprostenol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with epoprostenol.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "mebendazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "topotecan", "drug2": "buprenorphine", "interaction_type": 73, "interaction_text": "The serum concentration of buprenorphine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "phenindione", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nitric oxide", "interaction_type": 73, "interaction_text": "The serum concentration of nitric oxide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "midazolam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "colchicine", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "digitoxin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with disulfiram.", "severity": 2}
{"drug1": "penicillin v", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Varenicline", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "ibuprofen", "interaction_type": 73, "interaction_text": "The serum concentration of ibuprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Dabigatran etexilate", "interaction_type": 73, "interaction_text": "The serum concentration of Dabigatran etexilate can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "digoxin", "drug2": "mycophenolate mofetil", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolate mofetil can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "disopyramide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with disopyramide.", "severity": 2}
{"drug1": "gliclazide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with gliclazide.", "severity": 2}
{"drug1": "Axitinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "digoxin", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "domperidone", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "vincristine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "nimodipine", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Artesunate", "interaction_type": 73, "interaction_text": "The serum concentration of Artesunate can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "Eltrombopag", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with Eltrombopag.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "OXTRIPHYLLINE", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with OXTRIPHYLLINE.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with IVERMECTIN.", "severity": 2}
{"drug1": "indinavir", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with indinavir.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "aminophylline", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Melatonin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Melatonin.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "paromomycin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with paromomycin.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "ampicillin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with ampicillin.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "warfarin", "drug2": "Sitaxsentan", "interaction_type": 73, "interaction_text": "The serum concentration of Sitaxsentan can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "doxepin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "Levetiracetam", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Levetiracetam.", "severity": 2}
{"drug1": "vincristine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Rimonabant", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rimonabant.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ergocalciferol", "interaction_type": 73, "interaction_text": "The serum concentration of ergocalciferol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "aspirin", "interaction_type": 73, "interaction_text": "The serum concentration of aspirin can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "propranolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "promazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "bromazepam", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with bromazepam.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "equilin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "vincristine", "drug2": "diclofenac", "interaction_type": 73, "interaction_text": "The serum concentration of diclofenac can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "equilin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "pravastatin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "colchicine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "oxycodone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "colchicine", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "indapamide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "Apremilast", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "nevirapine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Glycopyrronium", "interaction_type": 73, "interaction_text": "The serum concentration of Glycopyrronium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "colchicine", "drug2": "palmitic acid", "interaction_type": 73, "interaction_text": "The serum concentration of palmitic acid can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "etizolam", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "etizolam", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "chlorzoxazone", "interaction_type": 73, "interaction_text": "The serum concentration of chlorzoxazone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "methylergonovine", "interaction_type": 73, "interaction_text": "The serum concentration of methylergonovine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "Liotrix", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Liotrix.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Masoprocol", "interaction_type": 73, "interaction_text": "The serum concentration of Masoprocol can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clofibrate", "interaction_type": 73, "interaction_text": "The serum concentration of clofibrate can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "betahistine", "drug2": "pargyline", "interaction_type": 73, "interaction_text": "The serum concentration of pargyline can be increased when it is combined with betahistine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "estazolam", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Vilanterol.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "estazolam", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "prednisone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "carvedilol", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "flunitrazepam", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with flunitrazepam.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "gemcitabine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with gemcitabine.", "severity": 2}
{"drug1": "teniposide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with zafirlukast.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "ATROPINE", "interaction_type": 73, "interaction_text": "The serum concentration of ATROPINE can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "budesonide", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with perphenazine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with methyprylon.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "methyprylon", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with methyprylon.", "severity": 2}
{"drug1": "desipramine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "estrone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Candesartan cilexetil", "interaction_type": 73, "interaction_text": "The serum concentration of Candesartan cilexetil can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "prednisone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with terbinafine.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "itraconazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Bendamustine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Bendamustine.", "severity": 2}
{"drug1": "cabergoline", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "menadione", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with menadione.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "selegiline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "imipramine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Bortezomib.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "Lenvatinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lenvatinib.", "severity": 2}
{"drug1": "pimozide", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "nitrazepam", "interaction_type": 73, "interaction_text": "The serum concentration of nitrazepam can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "tolfenamic acid", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with tolfenamic acid.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "METHSUXIMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of METHSUXIMIDE can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "methadone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "simvastatin", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "tiaprofenic acid", "interaction_type": 73, "interaction_text": "The serum concentration of tiaprofenic acid can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ajmaline", "interaction_type": 73, "interaction_text": "The serum concentration of ajmaline can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "busulfan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "meperidine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "isradipine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with isradipine.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with miconazole.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "Vorapaxar", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Vorapaxar.", "severity": 2}
{"drug1": "topotecan", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "azithromycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "teniposide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "phenindione", "drug2": "5-Fluorouracil", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorouracil can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dutasteride", "interaction_type": 73, "interaction_text": "The serum concentration of Dutasteride can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "loteprednol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "citalopram", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "ouabain", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "vindesine", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "colchicine", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Octreotide", "interaction_type": 73, "interaction_text": "The serum concentration of Octreotide can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with PONATINIB.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "progesterone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "halothane", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with halothane.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "digoxin", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "naloxone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "estrone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "cilostazol", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "sulfadiazine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with sulfadiazine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Lorcaserin", "interaction_type": 73, "interaction_text": "The serum concentration of Lorcaserin can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "propafenone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "zaleplon", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with zaleplon.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Rifampicin", "interaction_type": 73, "interaction_text": "The serum concentration of Rifampicin can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "proguanil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with proguanil.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with Atomoxetine.", "severity": 2}
{"drug1": "Fluciclovine (18F)", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Fluciclovine (18F).", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "amoxapine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "oxycodone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with oxycodone.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "metoprolol", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "D-mannitol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with D-mannitol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "vincristine", "drug2": "colchicine", "interaction_type": 73, "interaction_text": "The serum concentration of colchicine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "vincristine", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "lithium ion", "drug2": "acemetacin", "interaction_type": 73, "interaction_text": "The serum concentration of acemetacin can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "pimozide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Cariprazine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Cariprazine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "triazolam", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "mitoxantrone", "interaction_type": 73, "interaction_text": "The serum concentration of mitoxantrone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Imatinib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "colchicine", "drug2": "astemizole", "interaction_type": 73, "interaction_text": "The serum concentration of astemizole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "prednisone", "interaction_type": 73, "interaction_text": "The serum concentration of prednisone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "methotrexate", "drug2": "cloxacillin", "interaction_type": 73, "interaction_text": "The serum concentration of cloxacillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "dopamine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "azelastine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Almotriptan", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Almotriptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "maprotiline", "interaction_type": 73, "interaction_text": "The serum concentration of maprotiline can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "methadone", "interaction_type": 73, "interaction_text": "The serum concentration of methadone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "thioridazine", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Fingolimod", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Fingolimod.", "severity": 2}
{"drug1": "lithium ion", "drug2": "flurbiprofen", "interaction_type": 73, "interaction_text": "The serum concentration of flurbiprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "simvastatin", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "pergolide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "nifedipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "midazolam", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "doxepin", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "propofol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "DESOGESTREL", "interaction_type": 73, "interaction_text": "The serum concentration of DESOGESTREL can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "paramethasone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with paramethasone.", "severity": 2}
{"drug1": "etizolam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "metolazone", "drug2": "UMECLIDINIUM", "interaction_type": 73, "interaction_text": "The serum concentration of UMECLIDINIUM can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "flurbiprofen", "interaction_type": 73, "interaction_text": "The serum concentration of flurbiprofen can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Palonosetron", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Palonosetron.", "severity": 2}
{"drug1": "glimepiride", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with glimepiride.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "pimozide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pimozide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Artemether", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "PARAMETHADIONE", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with PARAMETHADIONE.", "severity": 2}
{"drug1": "PHENPROCOUMON", "drug2": "chloral hydrate", "interaction_type": 73, "interaction_text": "The serum concentration of chloral hydrate can be increased when it is combined with PHENPROCOUMON.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "levodopa", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with levodopa.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with methyclothiazide.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "salicylic acid", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with salicylic acid.", "severity": 2}
{"drug1": "Dapagliflozin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dapagliflozin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "thioridazine", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "alprazolam", "interaction_type": 73, "interaction_text": "The serum concentration of alprazolam can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "vincristine", "drug2": "NEOSTIGMINE", "interaction_type": 73, "interaction_text": "The serum concentration of NEOSTIGMINE can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with GESTODENE.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "fenoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of fenoprofen can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "buspirone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Cabozantinib", "interaction_type": 73, "interaction_text": "The serum concentration of Cabozantinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "acemetacin", "interaction_type": 73, "interaction_text": "The serum concentration of acemetacin can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "epinastine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "Perospirone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Perospirone.", "severity": 2}
{"drug1": "desipramine", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Afatinib", "drug2": "citalopram", "interaction_type": 73, "interaction_text": "The serum concentration of citalopram can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "bezafibrate", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with bezafibrate.", "severity": 2}
{"drug1": "sildenafil", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Mirabegron.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "nicergoline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with nicergoline.", "severity": 2}
{"drug1": "lamivudine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with lamivudine.", "severity": 2}
{"drug1": "lamivudine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with lamivudine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "mycophenolate mofetil", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolate mofetil can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "thioridazine", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "flumethasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "vincristine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "montelukast", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "budesonide", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "loteprednol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "felodipine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "budesonide", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "budesonide", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "domperidone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "domperidone", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "colchicine", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "zalcitabine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with zalcitabine.", "severity": 2}
{"drug1": "Avibactam", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Avibactam.", "severity": 2}
{"drug1": "vindesine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "methenamine", "interaction_type": 73, "interaction_text": "The serum concentration of methenamine can be increased when it is combined with chlorpropamide.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with mefloquine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Varenicline", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "ethanol", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "colchicine", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "nisoldipine", "interaction_type": 73, "interaction_text": "The serum concentration of nisoldipine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "enoxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with enoxacin.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Apixaban", "interaction_type": 73, "interaction_text": "The serum concentration of Apixaban can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "reserpine", "interaction_type": 73, "interaction_text": "The serum concentration of reserpine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "midazolam", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "topotecan", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "tolazamide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with tolazamide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Salsalate", "interaction_type": 73, "interaction_text": "The serum concentration of Salsalate can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "teniposide", "interaction_type": 73, "interaction_text": "The serum concentration of teniposide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Magnesium salicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium salicylate can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "phenindione", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "penbutolol", "interaction_type": 73, "interaction_text": "The serum concentration of penbutolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "colchicine", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "flecainide", "drug2": "dichlorphenamide", "interaction_type": 73, "interaction_text": "The serum concentration of dichlorphenamide can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "flecainide", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "vincristine", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "CARTEOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of CARTEOLOL can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "indapamide", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "metolazone", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Paricalcitol", "interaction_type": 73, "interaction_text": "The serum concentration of Paricalcitol can be increased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "dopamine", "interaction_type": 73, "interaction_text": "The serum concentration of dopamine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "cytarabine", "interaction_type": 73, "interaction_text": "The serum concentration of cytarabine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "triazolam", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "ketamine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ketamine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "simvastatin", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "medrysone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Ertapenem", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Ertapenem.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "astemizole", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "penbutolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with penbutolol.", "severity": 2}
{"drug1": "xylometazoline", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with xylometazoline.", "severity": 2}
{"drug1": "tetracycline", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with tetracycline.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "floxuridine", "interaction_type": 73, "interaction_text": "The serum concentration of floxuridine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "astemizole", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "doxepin", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "metolazone", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with vinorelbine.", "severity": 2}
{"drug1": "Fulvestrant", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Fulvestrant.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Rimonabant", "interaction_type": 73, "interaction_text": "The serum concentration of Rimonabant can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "codeine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "flutamide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "indapamide", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with labetalol.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "astemizole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "toremifene", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "irinotecan", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "timolol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "amoxapine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "vincristine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "difluprednate", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "vincristine", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "methylene blue", "drug2": "ATOVAQUONE", "interaction_type": 73, "interaction_text": "The serum concentration of ATOVAQUONE can be increased when it is combined with methylene blue.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "rivastigmine", "interaction_type": 73, "interaction_text": "The serum concentration of rivastigmine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "albendazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with albendazole.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "clofibrate", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "oxaprozin", "interaction_type": 73, "interaction_text": "The serum concentration of oxaprozin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "SODIUM BICARBONATE", "interaction_type": 73, "interaction_text": "The serum concentration of SODIUM BICARBONATE can be increased when it is combined with mecamylamine.", "severity": 2}
{"drug1": "warfarin", "drug2": "Esomeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of Esomeprazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "doxepin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "diazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with diazepam.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Pentolinium", "interaction_type": 73, "interaction_text": "The serum concentration of Pentolinium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "pimozide", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Silodosin", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "granisetron", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with granisetron.", "severity": 2}
{"drug1": "Olaparib", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "antipyrine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "propafenone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Olaparib", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "erythromycin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with diethylstilbestrol.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "SUFENTANIL", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with SUFENTANIL.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "chenodeoxycholic acid", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with chenodeoxycholic acid.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "irinotecan", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with antipyrine.", "severity": 2}
{"drug1": "irinotecan", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Mirabegron", "interaction_type": 73, "interaction_text": "The serum concentration of Mirabegron can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "loteprednol", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "sulfamethoxazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with sulfamethoxazole.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with amsacrine.", "severity": 2}
{"drug1": "ceritinib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "morphine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with morphine.", "severity": 2}
{"drug1": "Ribociclib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ribociclib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "mitomycin C", "interaction_type": 73, "interaction_text": "The serum concentration of mitomycin C can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "phenindione", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Rolapitant.", "severity": 2}
{"drug1": "busulfan", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with busulfan.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "sibutramine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "midazolam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "periciazine", "drug2": "amodiaquine", "interaction_type": 73, "interaction_text": "The serum concentration of amodiaquine can be increased when it is combined with periciazine.", "severity": 2}
{"drug1": "digoxin", "drug2": "sulindac", "interaction_type": 73, "interaction_text": "The serum concentration of sulindac can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "formoterol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with formoterol.", "severity": 2}
{"drug1": "zolpidem", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "digoxin", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Bivalirudin", "interaction_type": 73, "interaction_text": "The serum concentration of Bivalirudin can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "clindamycin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Tadalafil", "interaction_type": 73, "interaction_text": "The serum concentration of Tadalafil can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "diazepam", "interaction_type": 73, "interaction_text": "The serum concentration of diazepam can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "equilin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "pravastatin", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "vindesine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Pranlukast", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Pranlukast.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "losartan", "interaction_type": 73, "interaction_text": "The serum concentration of losartan can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "chlorpropamide", "interaction_type": 73, "interaction_text": "The serum concentration of chlorpropamide can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "imipramine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CICLOPIROX", "interaction_type": 73, "interaction_text": "The serum concentration of CICLOPIROX can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "enalapril", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "propofol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "formoterol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with formoterol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "loratadine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "protriptyline", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "vincristine", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Pimecrolimus", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Pimecrolimus.", "severity": 2}
{"drug1": "vincristine", "drug2": "pimozide", "interaction_type": 73, "interaction_text": "The serum concentration of pimozide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "quinacrine", "interaction_type": 73, "interaction_text": "The serum concentration of quinacrine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "vincristine", "drug2": "amsacrine", "interaction_type": 73, "interaction_text": "The serum concentration of amsacrine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "theophylline", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "topotecan", "drug2": "meprobamate", "interaction_type": 73, "interaction_text": "The serum concentration of meprobamate can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Olaparib", "interaction_type": 73, "interaction_text": "The serum concentration of Olaparib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with betamethasone.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "protriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of protriptyline can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "caffeine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "propofol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "dihydrotachysterol", "interaction_type": 73, "interaction_text": "The serum concentration of dihydrotachysterol can be increased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Imidafenacin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Imidafenacin.", "severity": 2}
{"drug1": "buspirone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "methotrexate", "drug2": "nabumetone", "interaction_type": 73, "interaction_text": "The serum concentration of nabumetone can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "ketorolac", "interaction_type": 73, "interaction_text": "The serum concentration of ketorolac can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "methotrexate", "drug2": "tenoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of tenoxicam can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "topotecan", "interaction_type": 73, "interaction_text": "The serum concentration of topotecan can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with carboplatin.", "severity": 2}
{"drug1": "doxepin", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "benzyl alcohol", "interaction_type": 73, "interaction_text": "The serum concentration of benzyl alcohol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "CABAZITAXEL", "interaction_type": 73, "interaction_text": "The serum concentration of CABAZITAXEL can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "chenodeoxycholic acid", "interaction_type": 73, "interaction_text": "The serum concentration of chenodeoxycholic acid can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Nebivolol", "interaction_type": 73, "interaction_text": "The serum concentration of Nebivolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "lidocaine", "drug2": "CARTEOLOL", "interaction_type": 73, "interaction_text": "The serum concentration of CARTEOLOL can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "topotecan", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "timolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with timolol.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "ambroxol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Phenelzine", "interaction_type": 73, "interaction_text": "The serum concentration of Phenelzine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "celecoxib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Vandetanib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Vandetanib.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "alosetron", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "didanosine", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with didanosine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "cilostazol", "drug2": "SERATRODAST", "interaction_type": 73, "interaction_text": "The serum concentration of SERATRODAST can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Prasugrel", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Prasugrel.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with moclobemide.", "severity": 2}
{"drug1": "folic acid", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with folic acid.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Sunitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Sunitinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "topotecan", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "citalopram", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "desipramine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pergolide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with pergolide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with diphenhydramine.", "severity": 2}
{"drug1": "metolazone", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with thiothixene.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "desipramine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ALFENTANIL", "interaction_type": 73, "interaction_text": "The serum concentration of ALFENTANIL can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ticlopidine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "formestane", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Methylnaltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of Methylnaltrexone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "desipramine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Olaparib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "finasteride", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with finasteride.", "severity": 2}
{"drug1": "formoterol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with formoterol.", "severity": 2}
{"drug1": "methotrexate", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with fexofenadine.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Dexmethylphenidate.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "theophylline", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "nafcillin", "interaction_type": 73, "interaction_text": "The serum concentration of nafcillin can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "dicumarol", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "pravastatin", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Afatinib", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Bedaquiline", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Bedaquiline.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with acebutolol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "sumatriptan", "interaction_type": 73, "interaction_text": "The serum concentration of sumatriptan can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "etoposide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "danazol", "interaction_type": 73, "interaction_text": "The serum concentration of danazol can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "Eszopiclone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Eszopiclone.", "severity": 2}
{"drug1": "Silodosin", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "triprolidine", "interaction_type": 73, "interaction_text": "The serum concentration of triprolidine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "estazolam", "interaction_type": 73, "interaction_text": "The serum concentration of estazolam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "lithium ion", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "digoxin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "alprenolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with alprenolol.", "severity": 2}
{"drug1": "nabumetone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with nabumetone.", "severity": 2}
{"drug1": "topotecan", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "pimozide", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "pimozide", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "pimozide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "clofibrate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with clofibrate.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "digoxin", "drug2": "salicylamide", "interaction_type": 73, "interaction_text": "The serum concentration of salicylamide can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "digoxin", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with oxprenolol.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "lovastatin", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "vindesine", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "theophylline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Apixaban", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "mebendazole", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "topotecan", "drug2": "IVERMECTIN", "interaction_type": 73, "interaction_text": "The serum concentration of IVERMECTIN can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "pimozide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "topotecan", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "famciclovir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with famciclovir.", "severity": 2}
{"drug1": "flunisolide", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with flunisolide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "domperidone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "DALFOPRISTIN", "interaction_type": 73, "interaction_text": "The serum concentration of DALFOPRISTIN can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "nicotinamide", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "dienestrol", "interaction_type": 73, "interaction_text": "The serum concentration of dienestrol can be increased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "progesterone", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "Varenicline", "drug2": "enoxacin", "interaction_type": 73, "interaction_text": "The serum concentration of enoxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Magnesium salicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Magnesium salicylate can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Salsalate", "interaction_type": 73, "interaction_text": "The serum concentration of Salsalate can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "estrone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with estrone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Ropivacaine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Ropivacaine.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Linagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Linagliptin can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "domperidone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "NATAMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of NATAMYCIN can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Metipranolol", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Metipranolol.", "severity": 2}
{"drug1": "epinastine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "zonisamide", "interaction_type": 73, "interaction_text": "The serum concentration of zonisamide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "cephradine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cephradine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Trabectedin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Trabectedin.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with mirtazapine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "naloxone", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "tolterodine", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "prednisone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "naloxone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Afatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Afatinib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metolazone", "drug2": "Tiotropium", "interaction_type": 73, "interaction_text": "The serum concentration of Tiotropium can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "teniposide", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with teniposide.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Nepafenac", "interaction_type": 73, "interaction_text": "The serum concentration of Nepafenac can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "cisapride", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "vindesine", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "vindesine", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with azelastine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Regorafenib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "triflupromazine", "interaction_type": 73, "interaction_text": "The serum concentration of triflupromazine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "metoprolol", "drug2": "doxepin", "interaction_type": 73, "interaction_text": "The serum concentration of doxepin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "loperamide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with loperamide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "prazosin", "interaction_type": 73, "interaction_text": "The serum concentration of prazosin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Macitentan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "amoxapine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with oxybutynin.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Artemether", "interaction_type": 73, "interaction_text": "The serum concentration of Artemether can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "midazolam", "interaction_type": 73, "interaction_text": "The serum concentration of midazolam can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with clenbuterol.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "olanzapine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with olanzapine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Regorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Regorafenib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "gabapentin", "interaction_type": 73, "interaction_text": "The serum concentration of gabapentin can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "sildenafil", "interaction_type": 73, "interaction_text": "The serum concentration of sildenafil can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "clonidine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with clonidine.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "caffeine", "interaction_type": 73, "interaction_text": "The serum concentration of caffeine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Belinostat", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Belinostat.", "severity": 2}
{"drug1": "metoprolol", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "lidocaine", "drug2": "betaxolol", "interaction_type": 73, "interaction_text": "The serum concentration of betaxolol can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "salicylamide", "interaction_type": 73, "interaction_text": "The serum concentration of salicylamide can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Dexfenfluramine", "interaction_type": 73, "interaction_text": "The serum concentration of Dexfenfluramine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "propafenone", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Naftifine", "interaction_type": 73, "interaction_text": "The serum concentration of Naftifine can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mycophenolate mofetil", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with mycophenolate mofetil.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "clonidine", "interaction_type": 73, "interaction_text": "The serum concentration of clonidine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "clozapine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with clozapine.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "benzocaine", "interaction_type": 73, "interaction_text": "The serum concentration of benzocaine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Clevidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Clevidipine can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Rosuvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Rosuvastatin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "sulfasalazine", "interaction_type": 73, "interaction_text": "The serum concentration of sulfasalazine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "clorazepate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clorazepate.", "severity": 2}
{"drug1": "tizanidine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "midazolam", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "Olopatadine", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Olopatadine.", "severity": 2}
{"drug1": "toremifene", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "propafenone", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with PERHEXILINE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "cabergoline", "interaction_type": 73, "interaction_text": "The serum concentration of cabergoline can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "etizolam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "lithium ion", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Midostaurin", "interaction_type": 73, "interaction_text": "The serum concentration of Midostaurin can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "selegiline", "drug2": "NORGESTIMATE", "interaction_type": 73, "interaction_text": "The serum concentration of NORGESTIMATE can be increased when it is combined with selegiline.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with rosiglitazone.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "pentoxifylline", "interaction_type": 73, "interaction_text": "The serum concentration of pentoxifylline can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Enzalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of Enzalutamide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "Apremilast", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Apremilast.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Levomilnacipran.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Choline magnesium trisalicylate", "interaction_type": 73, "interaction_text": "The serum concentration of Choline magnesium trisalicylate can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "methadone", "drug2": "anastrozole", "interaction_type": 73, "interaction_text": "The serum concentration of anastrozole can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Artemether", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Artemether.", "severity": 2}
{"drug1": "propafenone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "nicardipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "sildenafil", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Silodosin", "drug2": "daunorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of daunorubicin can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "flurazepam", "interaction_type": 73, "interaction_text": "The serum concentration of flurazepam can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "orphenadrine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with orphenadrine.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Paritaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Paritaprevir can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "celiprolol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with celiprolol.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "nicotine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "epinephrine", "interaction_type": 73, "interaction_text": "The serum concentration of epinephrine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Fidaxomicin", "interaction_type": 73, "interaction_text": "The serum concentration of Fidaxomicin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "budesonide", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tegafur", "interaction_type": 73, "interaction_text": "The serum concentration of tegafur can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Valbenazine", "interaction_type": 73, "interaction_text": "The serum concentration of Valbenazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with metoclopramide.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "imipramine", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "tamoxifen", "interaction_type": 73, "interaction_text": "The serum concentration of tamoxifen can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "nadolol", "interaction_type": 73, "interaction_text": "The serum concentration of nadolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "oxaprozin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with oxaprozin.", "severity": 2}
{"drug1": "LISURIDE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with LISURIDE.", "severity": 2}
{"drug1": "dyphylline", "drug2": "Carbimazole", "interaction_type": 73, "interaction_text": "The serum concentration of Carbimazole can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "quinidine", "drug2": "THYMOL", "interaction_type": 73, "interaction_text": "The serum concentration of THYMOL can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "estradiol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Levocetirizine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Levocetirizine.", "severity": 2}
{"drug1": "Raltegravir", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Raltegravir.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with nortriptyline.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "digoxin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "imipramine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "zonisamide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with haloperidol.", "severity": 2}
{"drug1": "APRINDINE", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with APRINDINE.", "severity": 2}
{"drug1": "sildenafil", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "atenolol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with atenolol.", "severity": 2}
{"drug1": "theophylline", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "digoxin", "drug2": "Pimecrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Pimecrolimus can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "topotecan", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "haloperidol", "interaction_type": 73, "interaction_text": "The serum concentration of haloperidol can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "zidovudine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Copanlisib", "interaction_type": 73, "interaction_text": "The serum concentration of Copanlisib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "domperidone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Lapatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Lapatinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "clomipramine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "felodipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with felodipine.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "CAPECITABINE", "interaction_type": 73, "interaction_text": "The serum concentration of CAPECITABINE can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "methadone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "BISOPROLOL", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with BISOPROLOL.", "severity": 2}
{"drug1": "cinnarizine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with cinnarizine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "amoxapine", "interaction_type": 73, "interaction_text": "The serum concentration of amoxapine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "nortriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of nortriptyline can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Rivaroxaban", "interaction_type": 73, "interaction_text": "The serum concentration of Rivaroxaban can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Etoricoxib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Bosutinib", "interaction_type": 73, "interaction_text": "The serum concentration of Bosutinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "diflorasone", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Levonorgestrel.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "diflorasone", "drug2": "estriol", "interaction_type": 73, "interaction_text": "The serum concentration of estriol can be increased when it is combined with diflorasone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with amcinonide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "prednisone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with prednisone.", "severity": 2}
{"drug1": "epinastine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with epinastine.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with acetylcholine.", "severity": 2}
{"drug1": "valsartan", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with valsartan.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nicotinamide", "interaction_type": 73, "interaction_text": "The serum concentration of nicotinamide can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with chlorpheniramine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with efavirenz.", "severity": 2}
{"drug1": "prazepam", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with prazepam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Safinamide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Safinamide.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "Atracurium besylate", "interaction_type": 73, "interaction_text": "The serum concentration of Atracurium besylate can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "colchicine", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "tolbutamide", "interaction_type": 73, "interaction_text": "The serum concentration of tolbutamide can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "tizanidine", "drug2": "theophylline", "interaction_type": 73, "interaction_text": "The serum concentration of theophylline can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "TETRABENAZINE", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with TETRABENAZINE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "tibolone", "interaction_type": 73, "interaction_text": "The serum concentration of tibolone can be increased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "sertraline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "pravastatin", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Suvorexant", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Suvorexant.", "severity": 2}
{"drug1": "zidovudine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with zidovudine.", "severity": 2}
{"drug1": "triazolam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Reboxetine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with azithromycin.", "severity": 2}
{"drug1": "equilin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with equilin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "digitoxin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "metoprolol", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "perphenazine", "interaction_type": 73, "interaction_text": "The serum concentration of perphenazine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "metoprolol", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "ZILEUTON", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ZILEUTON.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "Mometasone", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "dantrolene", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "simvastatin", "drug2": "clofazimine", "interaction_type": 73, "interaction_text": "The serum concentration of clofazimine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with anagrelide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "progesterone", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "vincristine", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "sildenafil", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Riociguat", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Riociguat", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Quinupristin", "interaction_type": 73, "interaction_text": "The serum concentration of Quinupristin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "metformin", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with metformin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Olaparib", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "Avanafil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "codeine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Aceprometazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Aceprometazine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nystatin", "interaction_type": 73, "interaction_text": "The serum concentration of nystatin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "colchicine", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "mebendazole", "interaction_type": 73, "interaction_text": "The serum concentration of mebendazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "simvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of simvastatin can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "colchicine", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "Olaparib", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Olaparib", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "methadone", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with methadone.", "severity": 2}
{"drug1": "Olaparib", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Macitentan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "leflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of leflunomide can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "doxepin", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "ADEFOVIR DIPIVOXIL", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with ADEFOVIR DIPIVOXIL.", "severity": 2}
{"drug1": "doxepin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Temsirolimus.", "severity": 2}
{"drug1": "doxepin", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with doxepin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "progesterone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with progesterone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "cilostazol", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tretinoin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with tretinoin.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Abemaciclib.", "severity": 2}
{"drug1": "midazolam", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Axitinib", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Axitinib.", "severity": 2}
{"drug1": "Mexiletine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Mexiletine.", "severity": 2}
{"drug1": "loratadine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "toremifene", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "Silodosin", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "flutamide", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with flutamide.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "Macitentan", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "dicumarol", "drug2": "ETHACRYNIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of ETHACRYNIC ACID can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "medrysone", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "medrysone", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "glipizide", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "carvedilol", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "nimesulide", "interaction_type": 73, "interaction_text": "The serum concentration of nimesulide can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "meperidine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "clotiazepam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with clotiazepam.", "severity": 2}
{"drug1": "methotrexate", "drug2": "oxyphenbutazone", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenbutazone can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Olsalazine", "interaction_type": 73, "interaction_text": "The serum concentration of Olsalazine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Tianeptine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "ropinirole", "interaction_type": 73, "interaction_text": "The serum concentration of ropinirole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "clomiphene", "interaction_type": 73, "interaction_text": "The serum concentration of clomiphene can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Diacerein", "interaction_type": 73, "interaction_text": "The serum concentration of Diacerein can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "celecoxib", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with celecoxib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "oxazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with oxazepam.", "severity": 2}
{"drug1": "cephalexin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "toremifene", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "pilocarpine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with pilocarpine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Lercanidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lercanidipine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "itraconazole", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "loratadine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "loratadine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with loratadine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "felbamate", "interaction_type": 73, "interaction_text": "The serum concentration of felbamate can be increased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "fenoprofen", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with fenoprofen.", "severity": 2}
{"drug1": "Afatinib", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "Tramadol", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Tramadol.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "digoxin", "drug2": "diflunisal", "interaction_type": 73, "interaction_text": "The serum concentration of diflunisal can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Rotigotine.", "severity": 2}
{"drug1": "sildenafil", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "Levomilnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Levomilnacipran can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "thiotepa", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with thiotepa.", "severity": 2}
{"drug1": "mestranol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with mestranol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "methimazole", "interaction_type": 73, "interaction_text": "The serum concentration of methimazole can be increased when it is combined with acetyldigitoxin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "norgestrel", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "nimodipine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "quinapril", "interaction_type": 73, "interaction_text": "The serum concentration of quinapril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with rosiglitazone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "roxithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of roxithromycin can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Delafloxacin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Delafloxacin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Daclatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Daclatasvir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "topotecan", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "methylergonovine", "drug2": "Saxagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Saxagliptin can be increased when it is combined with methylergonovine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "leflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of leflunomide can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "cyclopentolate", "interaction_type": 73, "interaction_text": "The serum concentration of cyclopentolate can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "allylestrenol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with allylestrenol.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with amoxapine.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Tramadol", "interaction_type": 73, "interaction_text": "The serum concentration of Tramadol can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "zonisamide", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Mometasone", "interaction_type": 73, "interaction_text": "The serum concentration of Mometasone can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "Varenicline", "drug2": "Gemifloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of Gemifloxacin can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Canagliflozin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "clindamycin", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with clindamycin.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "hydromorphone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with hydromorphone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with duloxetine.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "digoxin", "drug2": "potassium iodide", "interaction_type": 73, "interaction_text": "The serum concentration of potassium iodide can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "alosetron", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "caffeine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with caffeine.", "severity": 2}
{"drug1": "medrysone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with medrysone.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "indomethacin", "interaction_type": 73, "interaction_text": "The serum concentration of indomethacin can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Bevantolol", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Bevantolol.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "ethinyl estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of ethinyl estradiol can be increased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Eluxadoline", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Eluxadoline.", "severity": 2}
{"drug1": "flurazepam", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with flurazepam.", "severity": 2}
{"drug1": "Paricalcitol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Paricalcitol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "floctafenine", "interaction_type": 73, "interaction_text": "The serum concentration of floctafenine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "buspirone", "interaction_type": 73, "interaction_text": "The serum concentration of buspirone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "nilvadipine", "interaction_type": 73, "interaction_text": "The serum concentration of nilvadipine can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "hydromorphone", "interaction_type": 73, "interaction_text": "The serum concentration of hydromorphone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "amitriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of amitriptyline can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Pregabalin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Pregabalin.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ERGOTAMINE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "clomipramine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "colchicine", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Zuclopenthixol", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Zuclopenthixol.", "severity": 2}
{"drug1": "Thioproperazine", "drug2": "Halofantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Halofantrine can be increased when it is combined with Thioproperazine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "naratriptan", "drug2": "AMPHETAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of AMPHETAMINE can be increased when it is combined with naratriptan.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "atenolol", "interaction_type": 73, "interaction_text": "The serum concentration of atenolol can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "codeine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with codeine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "chlorprothixene", "interaction_type": 73, "interaction_text": "The serum concentration of chlorprothixene can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "dexamethasone", "interaction_type": 73, "interaction_text": "The serum concentration of dexamethasone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "metoprolol", "drug2": "propoxyphene", "interaction_type": 73, "interaction_text": "The serum concentration of propoxyphene can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "Romidepsin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Romidepsin.", "severity": 2}
{"drug1": "aminophylline", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with rapamycin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Torasemide", "interaction_type": 73, "interaction_text": "The serum concentration of Torasemide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Posaconazole.", "severity": 2}
{"drug1": "cilostazol", "drug2": "pantoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of pantoprazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "colchicine", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "prazepam", "interaction_type": 73, "interaction_text": "The serum concentration of prazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "quazepam", "interaction_type": 73, "interaction_text": "The serum concentration of quazepam can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "KETAZOLAM", "interaction_type": 73, "interaction_text": "The serum concentration of KETAZOLAM can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "colchicine", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Crisaborole", "interaction_type": 73, "interaction_text": "The serum concentration of Crisaborole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "SULFADOXINE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFADOXINE can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with nitrofurantoin.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "mesoridazine", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with mesoridazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Pazopanib", "interaction_type": 73, "interaction_text": "The serum concentration of Pazopanib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "testosterone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "vincristine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Voxilaprevir.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Erlotinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Erlotinib.", "severity": 2}
{"drug1": "norgestrel", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with ketoconazole.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Cinacalcet", "interaction_type": 73, "interaction_text": "The serum concentration of Cinacalcet can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "polythiazide", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "estazolam", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "pirenzepine", "interaction_type": 73, "interaction_text": "The serum concentration of pirenzepine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "astemizole", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with astemizole.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "alclometasone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "ketorolac", "interaction_type": 73, "interaction_text": "The serum concentration of ketorolac can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "nabumetone", "interaction_type": 73, "interaction_text": "The serum concentration of nabumetone can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "dapsone", "interaction_type": 73, "interaction_text": "The serum concentration of dapsone can be increased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Quinine", "drug2": "CALCIUM CARBONATE", "interaction_type": 73, "interaction_text": "The serum concentration of CALCIUM CARBONATE can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "tenoxicam", "interaction_type": 73, "interaction_text": "The serum concentration of tenoxicam can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Quinine", "drug2": "Aluminium hydroxide", "interaction_type": 73, "interaction_text": "The serum concentration of Aluminium hydroxide can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "tizanidine", "drug2": "olanzapine", "interaction_type": 73, "interaction_text": "The serum concentration of olanzapine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "sulfinpyrazone", "interaction_type": 73, "interaction_text": "The serum concentration of sulfinpyrazone can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "carvedilol", "interaction_type": 73, "interaction_text": "The serum concentration of carvedilol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "LEVOFLOXACIN", "interaction_type": 73, "interaction_text": "The serum concentration of LEVOFLOXACIN can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "tizanidine", "drug2": "omeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of omeprazole can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "glyburide", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with glyburide.", "severity": 2}
{"drug1": "risperidone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with doxazosin.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with Trovafloxacin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Micafungin", "interaction_type": 73, "interaction_text": "The serum concentration of Micafungin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Letermovir", "interaction_type": 73, "interaction_text": "The serum concentration of Letermovir can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ambroxol", "interaction_type": 73, "interaction_text": "The serum concentration of ambroxol can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "vincristine", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vincristine", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "vindesine", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "modafinil", "interaction_type": 73, "interaction_text": "The serum concentration of modafinil can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "trihexyphenidyl", "interaction_type": 73, "interaction_text": "The serum concentration of trihexyphenidyl can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "losartan", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with losartan.", "severity": 2}
{"drug1": "etizolam", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "Dolutegravir", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dolutegravir.", "severity": 2}
{"drug1": "trimipramine", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "SERTINDOLE", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with SERTINDOLE.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with acetylcholine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "tolbutamide", "interaction_type": 73, "interaction_text": "The serum concentration of tolbutamide can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "methotrexate", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Quinine", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Quinine.", "severity": 2}
{"drug1": "Maraviroc", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Maraviroc.", "severity": 2}
{"drug1": "MORICIZINE", "drug2": "hydroxychloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of hydroxychloroquine can be increased when it is combined with MORICIZINE.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Mometasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Mometasone.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "buspirone", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with buspirone.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "topotecan", "interaction_type": 73, "interaction_text": "The serum concentration of topotecan can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Ombitasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Ombitasvir can be increased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "benazepril", "interaction_type": 73, "interaction_text": "The serum concentration of benazepril can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "trimipramine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "FLUPHENAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUPHENAZINE can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "testosterone", "interaction_type": 73, "interaction_text": "The serum concentration of testosterone can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "risperidone", "interaction_type": 73, "interaction_text": "The serum concentration of risperidone can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "ISOSORBIDE DINITRATE", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ISOSORBIDE DINITRATE.", "severity": 2}
{"drug1": "anagrelide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with anagrelide.", "severity": 2}
{"drug1": "trazodone", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Daclatasvir.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Silodosin", "drug2": "miconazole", "interaction_type": 73, "interaction_text": "The serum concentration of miconazole can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Silodosin", "drug2": "nifedipine", "interaction_type": 73, "interaction_text": "The serum concentration of nifedipine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "colchicine", "drug2": "scopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of scopolamine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Silodosin", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "propafenone", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "colchicine", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Olaparib", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "zolpidem", "drug2": "hexetidine", "interaction_type": 73, "interaction_text": "The serum concentration of hexetidine can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "tizanidine", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Abiraterone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Abiraterone.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Dasatinib.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "temazepam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with temazepam.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "diltiazem", "interaction_type": 73, "interaction_text": "The serum concentration of diltiazem can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "nadolol", "interaction_type": 73, "interaction_text": "The serum concentration of nadolol can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Brigatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Brigatinib can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "topotecan", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "fenofibrate", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with fenofibrate.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "gabapentin", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with gabapentin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "codeine", "interaction_type": 73, "interaction_text": "The serum concentration of codeine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Crizotinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "cisapride", "drug2": "Miltefosine", "interaction_type": 73, "interaction_text": "The serum concentration of Miltefosine can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Valganciclovir", "drug2": "mycophenolic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolic acid can be increased when it is combined with Valganciclovir.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "zopiclone", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with zopiclone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "dihydroergotamine", "interaction_type": 73, "interaction_text": "The serum concentration of dihydroergotamine can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "digoxin", "drug2": "niflumic acid", "interaction_type": 73, "interaction_text": "The serum concentration of niflumic acid can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Isoflurophate", "interaction_type": 73, "interaction_text": "The serum concentration of Isoflurophate can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "mefenamic acid", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with mefenamic acid.", "severity": 2}
{"drug1": "Arotinolol", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Arotinolol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "nicardipine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with nicardipine.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ETONOGESTREL.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "pimozide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with pimozide.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Gramicidin D", "interaction_type": 73, "interaction_text": "The serum concentration of Gramicidin D can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "pentoxifylline", "drug2": "Mexiletine", "interaction_type": 73, "interaction_text": "The serum concentration of Mexiletine can be increased when it is combined with pentoxifylline.", "severity": 2}
{"drug1": "Treprostinil", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Treprostinil.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "lovastatin", "drug2": "hydralazine", "interaction_type": 73, "interaction_text": "The serum concentration of hydralazine can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with dextromethorphan.", "severity": 2}
{"drug1": "flunarizine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with flunarizine.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "zolmitriptan", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with zolmitriptan.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "alprazolam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "dapsone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "argatroban", "interaction_type": 73, "interaction_text": "The serum concentration of argatroban can be increased when it is combined with bromocriptine.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "Ketobemidone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with Ketobemidone.", "severity": 2}
{"drug1": "naloxone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with naloxone.", "severity": 2}
{"drug1": "phenindione", "drug2": "Oritavancin", "interaction_type": 73, "interaction_text": "The serum concentration of Oritavancin can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Brivaracetam", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Brivaracetam.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "simvastatin", "drug2": "resveratrol", "interaction_type": 73, "interaction_text": "The serum concentration of resveratrol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "difluprednate", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Baricitinib", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Baricitinib.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "Fesoterodine", "interaction_type": 73, "interaction_text": "The serum concentration of Fesoterodine can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "topotecan", "drug2": "Tolvaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Tolvaptan can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "cabergoline", "drug2": "ramipril", "interaction_type": 73, "interaction_text": "The serum concentration of ramipril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "tetracycline", "interaction_type": 73, "interaction_text": "The serum concentration of tetracycline can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "pravastatin", "drug2": "tranylcypromine", "interaction_type": 73, "interaction_text": "The serum concentration of tranylcypromine can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with ceritinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "paroxetine", "interaction_type": 73, "interaction_text": "The serum concentration of paroxetine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "formestane", "drug2": "QUINESTROL", "interaction_type": 73, "interaction_text": "The serum concentration of QUINESTROL can be increased when it is combined with formestane.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "oxybutynin", "interaction_type": 73, "interaction_text": "The serum concentration of oxybutynin can be increased when it is combined with trichlormethiazide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Ezetimibe", "interaction_type": 73, "interaction_text": "The serum concentration of Ezetimibe can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Enalaprilat", "interaction_type": 73, "interaction_text": "The serum concentration of Enalaprilat can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Voriconazole.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "bromazepam", "interaction_type": 73, "interaction_text": "The serum concentration of bromazepam can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "testosterone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "rabeprazole", "interaction_type": 73, "interaction_text": "The serum concentration of rabeprazole can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "quinacrine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with quinacrine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "raloxifene", "interaction_type": 73, "interaction_text": "The serum concentration of raloxifene can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "celecoxib", "interaction_type": 73, "interaction_text": "The serum concentration of celecoxib can be increased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "donepezil", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "nimodipine", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "erythromycin", "interaction_type": 73, "interaction_text": "The serum concentration of erythromycin can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "irinotecan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "irinotecan", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with irinotecan.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with Levomepromazine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Docosahexaenoic acid", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Docosahexaenoic acid.", "severity": 2}
{"drug1": "Erismodegib", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Erismodegib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "flumethasone", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with flumethasone.", "severity": 2}
{"drug1": "vindesine", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "selegiline", "interaction_type": 73, "interaction_text": "The serum concentration of selegiline can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Sitagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Sitagliptin can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "vindesine", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with vindesine.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Elbasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Elbasvir can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "topotecan", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Riociguat", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "imipramine", "interaction_type": 73, "interaction_text": "The serum concentration of imipramine can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "nilvadipine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nilvadipine.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with fluoxetine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Tipiracil", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Tipiracil.", "severity": 2}
{"drug1": "LESINURAD", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with LESINURAD.", "severity": 2}
{"drug1": "tizanidine", "drug2": "bromocriptine", "interaction_type": 73, "interaction_text": "The serum concentration of bromocriptine can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with ajmaline.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Tadalafil", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Tadalafil.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "disopyramide", "interaction_type": 73, "interaction_text": "The serum concentration of disopyramide can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "lidocaine", "interaction_type": 73, "interaction_text": "The serum concentration of lidocaine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "flecainide", "drug2": "methazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of methazolamide can be increased when it is combined with flecainide.", "severity": 2}
{"drug1": "alosetron", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with alosetron.", "severity": 2}
{"drug1": "Macitentan", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Macitentan.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Propiverine", "interaction_type": 73, "interaction_text": "The serum concentration of Propiverine can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "colchicine", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with RUCAPARIB.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "estrone", "interaction_type": 73, "interaction_text": "The serum concentration of estrone can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Bortezomib", "interaction_type": 73, "interaction_text": "The serum concentration of Bortezomib can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "enalapril", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with enalapril.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "mesalamine", "interaction_type": 73, "interaction_text": "The serum concentration of mesalamine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "bepridil", "interaction_type": 73, "interaction_text": "The serum concentration of bepridil can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "clomipramine", "interaction_type": 73, "interaction_text": "The serum concentration of clomipramine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with nitrazepam.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "PIRFENIDONE", "interaction_type": 73, "interaction_text": "The serum concentration of PIRFENIDONE can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "bupropion", "interaction_type": 73, "interaction_text": "The serum concentration of bupropion can be increased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with clenbuterol.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "chloroxine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroxine can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "sulfanilamide", "interaction_type": 73, "interaction_text": "The serum concentration of sulfanilamide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "mianserin", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with mianserin.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "TROLAMINE SALICYLATE", "drug2": "AMMONIUM CHLORIDE", "interaction_type": 73, "interaction_text": "The serum concentration of AMMONIUM CHLORIDE can be increased when it is combined with TROLAMINE SALICYLATE.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "triazolam", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "testosterone", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "cilostazol", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with ipratropium.", "severity": 2}
{"drug1": "phenoxybenzamine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with phenoxybenzamine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Pipotiazine", "interaction_type": 73, "interaction_text": "The serum concentration of Pipotiazine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Etoricoxib", "interaction_type": 73, "interaction_text": "The serum concentration of Etoricoxib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "thioridazine", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with sevoflurane.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "ropinirole", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "Avanafil", "drug2": "RUCAPARIB", "interaction_type": 73, "interaction_text": "The serum concentration of RUCAPARIB can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "glipizide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with glipizide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "EDOXABAN", "interaction_type": 73, "interaction_text": "The serum concentration of EDOXABAN can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "sildenafil", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "amiodarone", "interaction_type": 73, "interaction_text": "The serum concentration of amiodarone can be increased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Amrinone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Amrinone.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with triflupromazine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Fesoterodine.", "severity": 2}
{"drug1": "toremifene", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with toremifene.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Isavuconazonium", "interaction_type": 73, "interaction_text": "The serum concentration of Isavuconazonium can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Lomitapide.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Tianeptine", "interaction_type": 73, "interaction_text": "The serum concentration of Tianeptine can be increased when it is combined with Yohimbine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "indapamide", "drug2": "biperiden", "interaction_type": 73, "interaction_text": "The serum concentration of biperiden can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "topotecan", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "histamine", "interaction_type": 73, "interaction_text": "The serum concentration of histamine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Afatinib", "drug2": "spironolactone", "interaction_type": 73, "interaction_text": "The serum concentration of spironolactone can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "estazolam", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "colchicine", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "clotiazepam", "interaction_type": 73, "interaction_text": "The serum concentration of clotiazepam can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "colchicine", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "vincristine", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Ospemifene.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with praziquantel.", "severity": 2}
{"drug1": "diclofenac", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "aminophylline", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Dienogest", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dienogest.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Sunitinib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Ruxolitinib", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Ruxolitinib.", "severity": 2}
{"drug1": "propofol", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "pilocarpine", "interaction_type": 73, "interaction_text": "The serum concentration of pilocarpine can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "propofol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "warfarin", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with warfarin.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "isoniazid", "interaction_type": 73, "interaction_text": "The serum concentration of isoniazid can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "methylprednisolone", "interaction_type": 73, "interaction_text": "The serum concentration of methylprednisolone can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "sildenafil", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with sildenafil.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Indacaterol.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "Tasimelteon", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Tasimelteon.", "severity": 2}
{"drug1": "digitoxin", "drug2": "propafenone", "interaction_type": 73, "interaction_text": "The serum concentration of propafenone can be increased when it is combined with digitoxin.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "TROLAMINE SALICYLATE", "interaction_type": 73, "interaction_text": "The serum concentration of TROLAMINE SALICYLATE can be increased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "tolterodine", "interaction_type": 73, "interaction_text": "The serum concentration of tolterodine can be increased when it is combined with chlorothiazide.", "severity": 2}
{"drug1": "tinidazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with tinidazole.", "severity": 2}
{"drug1": "cabergoline", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Halofantrine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "sertraline", "interaction_type": 73, "interaction_text": "The serum concentration of sertraline can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Udenafil", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Udenafil.", "severity": 2}
{"drug1": "thioridazine", "drug2": "metoclopramide", "interaction_type": 73, "interaction_text": "The serum concentration of metoclopramide can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "modafinil", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with modafinil.", "severity": 2}
{"drug1": "calcitriol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with calcitriol.", "severity": 2}
{"drug1": "alclometasone", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "etoposide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with etoposide.", "severity": 2}
{"drug1": "propofol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with propofol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Dronabinol", "interaction_type": 73, "interaction_text": "The serum concentration of Dronabinol can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "argatroban", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with argatroban.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with ethinyl estradiol.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "testosterone", "drug2": "Lumacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Lumacaftor can be increased when it is combined with testosterone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "mestranol", "interaction_type": 73, "interaction_text": "The serum concentration of mestranol can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "ROLITETRACYCLINE", "interaction_type": 73, "interaction_text": "The serum concentration of ROLITETRACYCLINE can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lorcaserin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Temsirolimus", "interaction_type": 73, "interaction_text": "The serum concentration of Temsirolimus can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "propranolol", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "thioridazine", "drug2": "nortriptyline", "interaction_type": 73, "interaction_text": "The serum concentration of nortriptyline can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "zafirlukast", "interaction_type": 73, "interaction_text": "The serum concentration of zafirlukast can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "ADINAZOLAM", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ADINAZOLAM.", "severity": 2}
{"drug1": "topotecan", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "topotecan", "drug2": "novobiocin", "interaction_type": 73, "interaction_text": "The serum concentration of novobiocin can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "oxyphenonium", "interaction_type": 73, "interaction_text": "The serum concentration of oxyphenonium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "itraconazole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with itraconazole.", "severity": 2}
{"drug1": "propafenone", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "quinidine", "interaction_type": 73, "interaction_text": "The serum concentration of quinidine can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "midazolam", "drug2": "lisinopril", "interaction_type": 73, "interaction_text": "The serum concentration of lisinopril can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Ziprasidone.", "severity": 2}
{"drug1": "fusidic acid", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with fusidic acid.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "HYDROXYPROGESTERONE CAPROATE", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with HYDROXYPROGESTERONE CAPROATE.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "actinomycin D", "interaction_type": 73, "interaction_text": "The serum concentration of actinomycin D can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "CLONIXIN", "interaction_type": 73, "interaction_text": "The serum concentration of CLONIXIN can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "dipyridamole", "interaction_type": 73, "interaction_text": "The serum concentration of dipyridamole can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Droxicam", "interaction_type": 73, "interaction_text": "The serum concentration of Droxicam can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "erythromycin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "lithium ion", "drug2": "Loxoprofen", "interaction_type": 73, "interaction_text": "The serum concentration of Loxoprofen can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Retapamulin", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Retapamulin.", "severity": 2}
{"drug1": "tiagabine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with tiagabine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Risedronic acid", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with Risedronic acid.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Repaglinide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with Repaglinide.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "promazine", "interaction_type": 73, "interaction_text": "The serum concentration of promazine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Dothiepin", "interaction_type": 73, "interaction_text": "The serum concentration of Dothiepin can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "enalapril", "interaction_type": 73, "interaction_text": "The serum concentration of enalapril can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "methotrexate", "drug2": "nimesulide", "interaction_type": 73, "interaction_text": "The serum concentration of nimesulide can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "dantrolene", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with dantrolene.", "severity": 2}
{"drug1": "simvastatin", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "topotecan", "drug2": "trimipramine", "interaction_type": 73, "interaction_text": "The serum concentration of trimipramine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "Lumefantrine", "interaction_type": 73, "interaction_text": "The serum concentration of Lumefantrine can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "budesonide", "drug2": "Dronedarone", "interaction_type": 73, "interaction_text": "The serum concentration of Dronedarone can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "MEGESTROL ACETATE", "interaction_type": 73, "interaction_text": "The serum concentration of MEGESTROL ACETATE can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "mefloquine", "interaction_type": 73, "interaction_text": "The serum concentration of mefloquine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 73, "interaction_text": "The serum concentration of ISOSORBIDE DINITRATE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "Silodosin", "drug2": "fexofenadine", "interaction_type": 73, "interaction_text": "The serum concentration of fexofenadine can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Velpatasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Velpatasvir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "venlafaxine", "interaction_type": 73, "interaction_text": "The serum concentration of venlafaxine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "clemastine", "interaction_type": 73, "interaction_text": "The serum concentration of clemastine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Vardenafil", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Vardenafil.", "severity": 2}
{"drug1": "colchicine", "drug2": "nicardipine", "interaction_type": 73, "interaction_text": "The serum concentration of nicardipine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Atomoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Atomoxetine can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Methylscopolamine bromide", "interaction_type": 73, "interaction_text": "The serum concentration of Methylscopolamine bromide can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "topotecan", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "pentamidine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with pentamidine.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "fosinopril", "interaction_type": 73, "interaction_text": "The serum concentration of fosinopril can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "phenindione", "drug2": "methylphenidate", "interaction_type": 73, "interaction_text": "The serum concentration of methylphenidate can be increased when it is combined with phenindione.", "severity": 2}
{"drug1": "lithium ion", "drug2": "floctafenine", "interaction_type": 73, "interaction_text": "The serum concentration of floctafenine can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "Paliperidone", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Paliperidone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with tolterodine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "cytarabine", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with cytarabine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "cefmenoxime", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with cefmenoxime.", "severity": 2}
{"drug1": "triazolam", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "trimethoprim", "interaction_type": 73, "interaction_text": "The serum concentration of trimethoprim can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ketamine", "interaction_type": 73, "interaction_text": "The serum concentration of ketamine can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Riociguat", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with Riociguat.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Rosuvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Rosuvastatin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "cilostazol", "drug2": "rosiglitazone", "interaction_type": 73, "interaction_text": "The serum concentration of rosiglitazone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with methoxyflurane.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "nimodipine", "drug2": "nevirapine", "interaction_type": 73, "interaction_text": "The serum concentration of nevirapine can be increased when it is combined with nimodipine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 73, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "ouabain", "drug2": "chloroquine", "interaction_type": 73, "interaction_text": "The serum concentration of chloroquine can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "procyclidine", "interaction_type": 73, "interaction_text": "The serum concentration of procyclidine can be increased when it is combined with hydroflumethiazide.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "oxymorphone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with oxymorphone.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "metronidazole", "interaction_type": 73, "interaction_text": "The serum concentration of metronidazole can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Repaglinide", "interaction_type": 73, "interaction_text": "The serum concentration of Repaglinide can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Lomitapide", "interaction_type": 73, "interaction_text": "The serum concentration of Lomitapide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Grazoprevir", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Grazoprevir.", "severity": 2}
{"drug1": "HYDROCODONE", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with HYDROCODONE.", "severity": 2}
{"drug1": "quinidine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Reboxetine", "interaction_type": 73, "interaction_text": "The serum concentration of Reboxetine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "glyburide", "interaction_type": 73, "interaction_text": "The serum concentration of glyburide can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with loteprednol.", "severity": 2}
{"drug1": "pravastatin", "drug2": "metyrapone", "interaction_type": 73, "interaction_text": "The serum concentration of metyrapone can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Tiotropium.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "dopamine", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with dopamine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "clopidogrel", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with clopidogrel.", "severity": 2}
{"drug1": "phenytoin", "drug2": "PERHEXILINE", "interaction_type": 73, "interaction_text": "The serum concentration of PERHEXILINE can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "vincristine", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "IMIQUIMOD", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with IMIQUIMOD.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "morphine", "interaction_type": 73, "interaction_text": "The serum concentration of morphine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "acemetacin", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with acemetacin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "sertraline", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with sertraline.", "severity": 2}
{"drug1": "ondansetron", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ondansetron.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "metoprolol", "drug2": "irbesartan", "interaction_type": 73, "interaction_text": "The serum concentration of irbesartan can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "ACENOCOUMAROL", "drug2": "disulfiram", "interaction_type": 73, "interaction_text": "The serum concentration of disulfiram can be increased when it is combined with ACENOCOUMAROL.", "severity": 2}
{"drug1": "metoprolol", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "imipramine", "drug2": "Vildagliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Vildagliptin can be increased when it is combined with imipramine.", "severity": 2}
{"drug1": "propranolol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with propranolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "doxorubicin", "interaction_type": 73, "interaction_text": "The serum concentration of doxorubicin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with cimetidine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Teriflunomide", "interaction_type": 73, "interaction_text": "The serum concentration of Teriflunomide can be increased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Imatinib", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Imatinib.", "severity": 2}
{"drug1": "zonisamide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with zonisamide.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "protriptyline", "drug2": "MOEXIPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of MOEXIPRIL can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "naltrexone", "interaction_type": 73, "interaction_text": "The serum concentration of naltrexone can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "terbinafine", "interaction_type": 73, "interaction_text": "The serum concentration of terbinafine can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Ethylmorphine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Ethylmorphine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Isoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Isoconazole can be increased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "norfloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of norfloxacin can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "nitrendipine", "interaction_type": 73, "interaction_text": "The serum concentration of nitrendipine can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Levobupivacaine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Levobupivacaine.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "BALSALAZIDE", "interaction_type": 73, "interaction_text": "The serum concentration of BALSALAZIDE can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "lovastatin", "interaction_type": 73, "interaction_text": "The serum concentration of lovastatin can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Aripiprazole.", "severity": 2}
{"drug1": "metoprolol", "drug2": "mirtazapine", "interaction_type": 73, "interaction_text": "The serum concentration of mirtazapine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "timolol", "interaction_type": 73, "interaction_text": "The serum concentration of timolol can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "terconazole", "interaction_type": 73, "interaction_text": "The serum concentration of terconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "clotrimazole", "interaction_type": 73, "interaction_text": "The serum concentration of clotrimazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "doxycycline", "interaction_type": 73, "interaction_text": "The serum concentration of doxycycline can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with Idelalisib.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with CABAZITAXEL.", "severity": 2}
{"drug1": "colchicine", "drug2": "vinblastine", "interaction_type": 73, "interaction_text": "The serum concentration of vinblastine can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "colchicine", "drug2": "propranolol", "interaction_type": 73, "interaction_text": "The serum concentration of propranolol can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "methotrexate", "drug2": "mycophenolic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mycophenolic acid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Tofacitinib", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with Tofacitinib.", "severity": 2}
{"drug1": "bepridil", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with bepridil.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "ouabain", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "cyclosporin A", "interaction_type": 73, "interaction_text": "The serum concentration of cyclosporin A can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "thiopental", "interaction_type": 73, "interaction_text": "The serum concentration of thiopental can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "dicumarol", "drug2": "bicalutamide", "interaction_type": 73, "interaction_text": "The serum concentration of bicalutamide can be increased when it is combined with dicumarol.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with moclobemide.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Alogliptin", "interaction_type": 73, "interaction_text": "The serum concentration of Alogliptin can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Nilotinib.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "propofol", "interaction_type": 73, "interaction_text": "The serum concentration of propofol can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "acetazolamide", "interaction_type": 73, "interaction_text": "The serum concentration of acetazolamide can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "zolpidem", "drug2": "amphotericin b", "interaction_type": 73, "interaction_text": "The serum concentration of amphotericin b can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "TASOSARTAN", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with TASOSARTAN.", "severity": 2}
{"drug1": "Dexchlorpheniramine maleate", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "tacrolimus", "interaction_type": 73, "interaction_text": "The serum concentration of tacrolimus can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Copanlisib", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Copanlisib.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "proguanil", "interaction_type": 73, "interaction_text": "The serum concentration of proguanil can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "colchicine", "drug2": "Sorafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Sorafenib can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "indapamide", "drug2": "orphenadrine", "interaction_type": 73, "interaction_text": "The serum concentration of orphenadrine can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "colchicine", "drug2": "progesterone", "interaction_type": 73, "interaction_text": "The serum concentration of progesterone can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "colchicine", "drug2": "digoxin", "interaction_type": 73, "interaction_text": "The serum concentration of digoxin can be increased when it is combined with colchicine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "roxithromycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with roxithromycin.", "severity": 2}
{"drug1": "topotecan", "drug2": "Voxilaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Voxilaprevir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "ropinirole", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ropinirole.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Milnacipran", "interaction_type": 73, "interaction_text": "The serum concentration of Milnacipran can be increased when it is combined with carvedilol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Eplerenone", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with Eplerenone.", "severity": 2}
{"drug1": "podophyllotoxin", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with podophyllotoxin.", "severity": 2}
{"drug1": "cilostazol", "drug2": "TROLEANDOMYCIN", "interaction_type": 73, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "tizanidine", "drug2": "ZILEUTON", "interaction_type": 73, "interaction_text": "The serum concentration of ZILEUTON can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Ambrisentan", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Ambrisentan.", "severity": 2}
{"drug1": "Lurasidone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Lurasidone.", "severity": 2}
{"drug1": "citalopram", "drug2": "ticlopidine", "interaction_type": 73, "interaction_text": "The serum concentration of ticlopidine can be increased when it is combined with citalopram.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with chlorthalidone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "tizanidine", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with tizanidine.", "severity": 2}
{"drug1": "Pomalidomide", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Pomalidomide.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Letermovir.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "clozapine", "interaction_type": 73, "interaction_text": "The serum concentration of clozapine can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "vincristine", "drug2": "glycerol", "interaction_type": 73, "interaction_text": "The serum concentration of glycerol can be increased when it is combined with vincristine.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Ticagrelor", "interaction_type": 73, "interaction_text": "The serum concentration of Ticagrelor can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "prochlorperazine", "drug2": "SULFALENE", "interaction_type": 73, "interaction_text": "The serum concentration of SULFALENE can be increased when it is combined with prochlorperazine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Rilpivirine", "interaction_type": 73, "interaction_text": "The serum concentration of Rilpivirine can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "ambroxol", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "PONATINIB", "interaction_type": 73, "interaction_text": "The serum concentration of PONATINIB can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Dronabinol.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ticagrelor.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "metronidazole", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with metronidazole.", "severity": 2}
{"drug1": "estradiol", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with estradiol.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with Apixaban.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Agomelatine", "drug2": "Zucapsaicin", "interaction_type": 73, "interaction_text": "The serum concentration of Zucapsaicin can be increased when it is combined with Agomelatine.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "sibutramine", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with sibutramine.", "severity": 2}
{"drug1": "Ulipristal", "drug2": "isradipine", "interaction_type": 73, "interaction_text": "The serum concentration of isradipine can be increased when it is combined with Ulipristal.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "fluoxetine", "interaction_type": 73, "interaction_text": "The serum concentration of fluoxetine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Nebivolol", "drug2": "duloxetine", "interaction_type": 73, "interaction_text": "The serum concentration of duloxetine can be increased when it is combined with Nebivolol.", "severity": 2}
{"drug1": "Permethrin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Permethrin.", "severity": 2}
{"drug1": "digoxin", "drug2": "fenbufen", "interaction_type": 73, "interaction_text": "The serum concentration of fenbufen can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "digoxin", "drug2": "ETOFENAMATE", "interaction_type": 73, "interaction_text": "The serum concentration of ETOFENAMATE can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Pipotiazine.", "severity": 2}
{"drug1": "chlorzoxazone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with chlorzoxazone.", "severity": 2}
{"drug1": "alprazolam", "drug2": "Ximelagatran", "interaction_type": 73, "interaction_text": "The serum concentration of Ximelagatran can be increased when it is combined with alprazolam.", "severity": 2}
{"drug1": "Ramelteon", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Ramelteon.", "severity": 2}
{"drug1": "Dutasteride", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Dutasteride.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "budesonide", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "metolazone", "drug2": "methscopolamine", "interaction_type": 73, "interaction_text": "The serum concentration of methscopolamine can be increased when it is combined with metolazone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Telmisartan", "interaction_type": 73, "interaction_text": "The serum concentration of Telmisartan can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "Desloratadine", "interaction_type": 73, "interaction_text": "The serum concentration of Desloratadine can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with nitrendipine.", "severity": 2}
{"drug1": "tibolone", "drug2": "l-ascorbic acid", "interaction_type": 73, "interaction_text": "The serum concentration of l-ascorbic acid can be increased when it is combined with tibolone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Vitamin D3.", "severity": 2}
{"drug1": "5-Fluorouracil", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with 5-Fluorouracil.", "severity": 2}
{"drug1": "ambroxol", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with ambroxol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Asunaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Asunaprevir can be increased when it is combined with protriptyline.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "PRIMAQUINE", "interaction_type": 73, "interaction_text": "The serum concentration of PRIMAQUINE can be increased when it is combined with FLUPHENAZINE.", "severity": 2}
{"drug1": "rizatriptan", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with rizatriptan.", "severity": 2}
{"drug1": "BREXPIPRAZOLE", "drug2": "Imatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Imatinib can be increased when it is combined with BREXPIPRAZOLE.", "severity": 2}
{"drug1": "Olaparib", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Olaparib.", "severity": 2}
{"drug1": "Silodosin", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with Silodosin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "azithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of azithromycin can be increased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "donepezil", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with donepezil.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "hydrocortisone", "interaction_type": 73, "interaction_text": "The serum concentration of hydrocortisone can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "cephalexin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "rapamycin", "interaction_type": 73, "interaction_text": "The serum concentration of rapamycin can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Conivaptan", "interaction_type": 73, "interaction_text": "The serum concentration of Conivaptan can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "loratadine", "interaction_type": 73, "interaction_text": "The serum concentration of loratadine can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sulfamethoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfamethoxazole can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ethanol", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ethanol.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Baricitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Baricitinib can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "polythiazide", "drug2": "propantheline", "interaction_type": 73, "interaction_text": "The serum concentration of propantheline can be increased when it is combined with polythiazide.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Afatinib", "drug2": "ciprofloxacin", "interaction_type": 73, "interaction_text": "The serum concentration of ciprofloxacin can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Afatinib", "drug2": "cyclophosphamide", "interaction_type": 73, "interaction_text": "The serum concentration of cyclophosphamide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "Cabozantinib", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Cabozantinib.", "severity": 2}
{"drug1": "nicotine", "drug2": "cimetidine", "interaction_type": 73, "interaction_text": "The serum concentration of cimetidine can be increased when it is combined with nicotine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "thioridazine", "drug2": "pentamidine", "interaction_type": 73, "interaction_text": "The serum concentration of pentamidine can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "norgestrel", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "chlordiazepoxide", "drug2": "Palbociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Palbociclib can be increased when it is combined with chlordiazepoxide.", "severity": 2}
{"drug1": "dolasetron", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with dolasetron.", "severity": 2}
{"drug1": "TAMSULOSIN", "drug2": "Levomepromazine", "interaction_type": 73, "interaction_text": "The serum concentration of Levomepromazine can be increased when it is combined with TAMSULOSIN.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "ifosfamide", "interaction_type": 73, "interaction_text": "The serum concentration of ifosfamide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "pergolide", "interaction_type": 73, "interaction_text": "The serum concentration of pergolide can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Telaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Telaprevir can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Cilastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Cilastatin can be increased when it is combined with dihydroergotamine.", "severity": 2}
{"drug1": "nateglinide", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "budesonide", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with budesonide.", "severity": 2}
{"drug1": "cephalexin", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with cephalexin.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "salicylic acid", "interaction_type": 73, "interaction_text": "The serum concentration of salicylic acid can be increased when it is combined with Dofetilide.", "severity": 2}
{"drug1": "Flibanserin", "drug2": "Delavirdine", "interaction_type": 73, "interaction_text": "The serum concentration of Delavirdine can be increased when it is combined with Flibanserin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Nilotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Nilotinib can be increased when it is combined with Ivabradine.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "Aclidinium", "interaction_type": 73, "interaction_text": "The serum concentration of Aclidinium can be increased when it is combined with BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Varenicline", "drug2": "ranitidine", "interaction_type": 73, "interaction_text": "The serum concentration of ranitidine can be increased when it is combined with Varenicline.", "severity": 2}
{"drug1": "norgestrel", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with norgestrel.", "severity": 2}
{"drug1": "midazolam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with midazolam.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "loperamide", "interaction_type": 73, "interaction_text": "The serum concentration of loperamide can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "trifluoperazine", "interaction_type": 73, "interaction_text": "The serum concentration of trifluoperazine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "Idelalisib", "interaction_type": 73, "interaction_text": "The serum concentration of Idelalisib can be increased when it is combined with Panobinostat.", "severity": 2}
{"drug1": "metoprolol", "drug2": "quetiapine", "interaction_type": 73, "interaction_text": "The serum concentration of quetiapine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Remikiren", "interaction_type": 73, "interaction_text": "The serum concentration of Remikiren can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "probenecid", "interaction_type": 73, "interaction_text": "The serum concentration of probenecid can be increased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "albendazole", "interaction_type": 73, "interaction_text": "The serum concentration of albendazole can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "gemfibrozil", "interaction_type": 73, "interaction_text": "The serum concentration of gemfibrozil can be increased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "trazodone", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with trazodone.", "severity": 2}
{"drug1": "Ledipasvir", "drug2": "dextromethorphan", "interaction_type": 73, "interaction_text": "The serum concentration of dextromethorphan can be increased when it is combined with Ledipasvir.", "severity": 2}
{"drug1": "lithium ion", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Crizotinib", "interaction_type": 73, "interaction_text": "The serum concentration of Crizotinib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "fluvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of fluvastatin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "dimethyl sulfoxide", "interaction_type": 73, "interaction_text": "The serum concentration of dimethyl sulfoxide can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Rosuvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of Rosuvastatin can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "docetaxel", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with docetaxel.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ecabet", "interaction_type": 73, "interaction_text": "The serum concentration of Ecabet can be increased when it is combined with digoxin.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 73, "interaction_text": "The serum concentration of GLYCEROL PHENYLBUTYRATE can be increased when it is combined with Tolvaptan.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Deferasirox", "interaction_type": 73, "interaction_text": "The serum concentration of Deferasirox can be increased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with Propoxyphene napsylate.", "severity": 2}
{"drug1": "dapsone", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with dapsone.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "Caspofungin", "interaction_type": 73, "interaction_text": "The serum concentration of Caspofungin can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "metoprolol", "drug2": "fluvoxamine", "interaction_type": 73, "interaction_text": "The serum concentration of fluvoxamine can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "pravastatin", "interaction_type": 73, "interaction_text": "The serum concentration of pravastatin can be increased when it is combined with metoprolol.", "severity": 2}
{"drug1": "lovastatin", "drug2": "arsenic trioxide", "interaction_type": 73, "interaction_text": "The serum concentration of arsenic trioxide can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "Ibrutinib", "drug2": "Quinine", "interaction_type": 73, "interaction_text": "The serum concentration of Quinine can be increased when it is combined with Ibrutinib.", "severity": 2}
{"drug1": "lovastatin", "drug2": "itraconazole", "interaction_type": 73, "interaction_text": "The serum concentration of itraconazole can be increased when it is combined with lovastatin.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Lopinavir", "interaction_type": 73, "interaction_text": "The serum concentration of Lopinavir can be increased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with Ivacaftor.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "Metixene", "interaction_type": 73, "interaction_text": "The serum concentration of Metixene can be increased when it is combined with hydrochlorothiazide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Pibrentasvir", "interaction_type": 73, "interaction_text": "The serum concentration of Pibrentasvir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Glecaprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Glecaprevir can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Enasidenib", "interaction_type": 73, "interaction_text": "The serum concentration of Enasidenib can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Ribociclib", "interaction_type": 73, "interaction_text": "The serum concentration of Ribociclib can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Velpatasvir.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Atazanavir", "interaction_type": 73, "interaction_text": "The serum concentration of Atazanavir can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "domperidone", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with domperidone.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "diphenhydramine", "interaction_type": 73, "interaction_text": "The serum concentration of diphenhydramine can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "atorvastatin", "interaction_type": 73, "interaction_text": "The serum concentration of atorvastatin can be increased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with reserpine.", "severity": 2}
{"drug1": "quinidine", "drug2": "butenafine", "interaction_type": 73, "interaction_text": "The serum concentration of butenafine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "bupivacaine", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with bupivacaine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Spirapril", "interaction_type": 73, "interaction_text": "The serum concentration of Spirapril can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "quinidine", "drug2": "5-Fluorocytosine", "interaction_type": 73, "interaction_text": "The serum concentration of 5-Fluorocytosine can be increased when it is combined with quinidine.", "severity": 2}
{"drug1": "minoxidil", "drug2": "VALPROIC ACID", "interaction_type": 73, "interaction_text": "The serum concentration of VALPROIC ACID can be increased when it is combined with minoxidil.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "amantadine", "interaction_type": 73, "interaction_text": "The serum concentration of amantadine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "etoposide", "interaction_type": 73, "interaction_text": "The serum concentration of etoposide can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "liothyronine", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with liothyronine.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Cobicistat", "interaction_type": 73, "interaction_text": "The serum concentration of Cobicistat can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "felodipine", "interaction_type": 73, "interaction_text": "The serum concentration of felodipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "promethazine", "interaction_type": 73, "interaction_text": "The serum concentration of promethazine can be increased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "ceritinib", "interaction_type": 73, "interaction_text": "The serum concentration of ceritinib can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "cisapride", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with cisapride.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Efonidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Efonidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lacidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Lacidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Benidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Benidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Azelnidipine", "interaction_type": 73, "interaction_text": "The serum concentration of Azelnidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cilnidipine", "interaction_type": 73, "interaction_text": "The serum concentration of cilnidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "manidipine", "interaction_type": 73, "interaction_text": "The serum concentration of manidipine can be increased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Ixabepilone", "drug2": "ketoconazole", "interaction_type": 73, "interaction_text": "The serum concentration of ketoconazole can be increased when it is combined with Ixabepilone.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Levalbuterol", "interaction_type": 73, "interaction_text": "The serum concentration of Levalbuterol can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "alfuzosin", "drug2": "Fosamprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of Fosamprenavir can be increased when it is combined with alfuzosin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "benzoic acid", "interaction_type": 73, "interaction_text": "The serum concentration of benzoic acid can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Afatinib", "drug2": "cilazapril", "interaction_type": 73, "interaction_text": "The serum concentration of cilazapril can be increased when it is combined with Afatinib.", "severity": 2}
{"drug1": "alclometasone", "drug2": "diethylstilbestrol", "interaction_type": 73, "interaction_text": "The serum concentration of diethylstilbestrol can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with clomipramine.", "severity": 2}
{"drug1": "meperidine", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with meperidine.", "severity": 2}
{"drug1": "topotecan", "drug2": "Dasabuvir", "interaction_type": 73, "interaction_text": "The serum concentration of Dasabuvir can be increased when it is combined with topotecan.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "nelfinavir", "interaction_type": 73, "interaction_text": "The serum concentration of nelfinavir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Dothiepin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "sulfisoxazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulfisoxazole can be increased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Cevimeline", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Cevimeline.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with ELIGLUSTAT.", "severity": 2}
{"drug1": "zolpidem", "drug2": "sulconazole", "interaction_type": 73, "interaction_text": "The serum concentration of sulconazole can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Phensuximide", "interaction_type": 73, "interaction_text": "The serum concentration of Phensuximide can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "estramustine", "interaction_type": 73, "interaction_text": "The serum concentration of estramustine can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "quazepam", "drug2": "STIRIPENTOL", "interaction_type": 73, "interaction_text": "The serum concentration of STIRIPENTOL can be increased when it is combined with quazepam.", "severity": 2}
{"drug1": "tobramycin", "drug2": "Tenofovir disoproxil", "interaction_type": 73, "interaction_text": "The serum concentration of Tenofovir disoproxil can be increased when it is combined with tobramycin.", "severity": 2}
{"drug1": "spiramycin", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with spiramycin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with norethindrone.", "severity": 2}
{"drug1": "simvastatin", "drug2": "ethanol", "interaction_type": 73, "interaction_text": "The serum concentration of ethanol can be increased when it is combined with simvastatin.", "severity": 2}
{"drug1": "VORTIOXETINE", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with VORTIOXETINE.", "severity": 2}
{"drug1": "cabergoline", "drug2": "trandolapril", "interaction_type": 73, "interaction_text": "The serum concentration of trandolapril can be increased when it is combined with cabergoline.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Vilazodone.", "severity": 2}
{"drug1": "quetiapine", "drug2": "ritonavir", "interaction_type": 73, "interaction_text": "The serum concentration of ritonavir can be increased when it is combined with quetiapine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "desipramine", "interaction_type": 73, "interaction_text": "The serum concentration of desipramine can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "pravastatin", "drug2": "clindamycin", "interaction_type": 73, "interaction_text": "The serum concentration of clindamycin can be increased when it is combined with pravastatin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with lidocaine.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "Salbutamol", "interaction_type": 73, "interaction_text": "The serum concentration of Salbutamol can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "alclometasone", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with alclometasone.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "indinavir", "interaction_type": 73, "interaction_text": "The serum concentration of indinavir can be increased when it is combined with Dronedarone.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Abemaciclib", "interaction_type": 73, "interaction_text": "The serum concentration of Abemaciclib can be increased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "triazolam", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with triazolam.", "severity": 2}
{"drug1": "Coenzyme Q10", "drug2": "tioconazole", "interaction_type": 73, "interaction_text": "The serum concentration of tioconazole can be increased when it is combined with Coenzyme Q10.", "severity": 2}
{"drug1": "Gliquidone", "drug2": "fluconazole", "interaction_type": 73, "interaction_text": "The serum concentration of fluconazole can be increased when it is combined with Gliquidone.", "severity": 2}
{"drug1": "propafenone", "drug2": "cocaine", "interaction_type": 73, "interaction_text": "The serum concentration of cocaine can be increased when it is combined with propafenone.", "severity": 2}
{"drug1": "amprenavir", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with amprenavir.", "severity": 2}
{"drug1": "nateglinide", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with nateglinide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "VERAPAMIL", "interaction_type": 73, "interaction_text": "The serum concentration of VERAPAMIL can be increased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with erythromycin.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "Vitamin D3", "interaction_type": 73, "interaction_text": "The serum concentration of Vitamin D3 can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "DIHYDROCODEINE", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with DIHYDROCODEINE.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Gefitinib", "interaction_type": 73, "interaction_text": "The serum concentration of Gefitinib can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "acetaminophen", "interaction_type": 73, "interaction_text": "The serum concentration of acetaminophen can be increased when it is combined with Naloxegol.", "severity": 2}
{"drug1": "VANCOMYCIN", "drug2": "azelastine", "interaction_type": 73, "interaction_text": "The serum concentration of azelastine can be increased when it is combined with VANCOMYCIN.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "GUANFACINE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with GUANFACINE.", "severity": 2}
{"drug1": "Asenapine", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "dyphylline", "drug2": "estradiol", "interaction_type": 73, "interaction_text": "The serum concentration of estradiol can be increased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Voriconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Voriconazole can be increased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Asenapine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Vemurafenib", "interaction_type": 73, "interaction_text": "The serum concentration of Vemurafenib can be increased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "acetylcholine", "drug2": "Panobinostat", "interaction_type": 73, "interaction_text": "The serum concentration of Panobinostat can be increased when it is combined with acetylcholine.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Ziprasidone", "interaction_type": 73, "interaction_text": "The serum concentration of Ziprasidone can be increased when it is combined with thioridazine.", "severity": 2}
{"drug1": "Conivaptan", "drug2": "ERGOTAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of ERGOTAMINE can be increased when it is combined with Conivaptan.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "doxazosin", "interaction_type": 73, "interaction_text": "The serum concentration of doxazosin can be increased when it is combined with RANOLAZINE.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "docetaxel", "interaction_type": 73, "interaction_text": "The serum concentration of docetaxel can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Rosuvastatin", "drug2": "Eltrombopag", "interaction_type": 73, "interaction_text": "The serum concentration of Eltrombopag can be increased when it is combined with Rosuvastatin.", "severity": 2}
{"drug1": "mepivacaine", "drug2": "metoprolol", "interaction_type": 73, "interaction_text": "The serum concentration of metoprolol can be increased when it is combined with mepivacaine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "lansoprazole", "interaction_type": 73, "interaction_text": "The serum concentration of lansoprazole can be increased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "diclofenac", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with diclofenac.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with methoxsalen.", "severity": 2}
{"drug1": "Pitavastatin", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with Pitavastatin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "ethopropazine", "interaction_type": 73, "interaction_text": "The serum concentration of ethopropazine can be increased when it is combined with QUINETHAZONE.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Olsalazine", "interaction_type": 73, "interaction_text": "The serum concentration of Olsalazine can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Vismodegib", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with Vismodegib.", "severity": 2}
{"drug1": "indapamide", "drug2": "ANISOTROPINE METHYLBROMIDE", "interaction_type": 73, "interaction_text": "The serum concentration of ANISOTROPINE METHYLBROMIDE can be increased when it is combined with indapamide.", "severity": 2}
{"drug1": "methotrexate", "drug2": "NAPROXEN", "interaction_type": 73, "interaction_text": "The serum concentration of NAPROXEN can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "methotrexate", "drug2": "mefenamic acid", "interaction_type": 73, "interaction_text": "The serum concentration of mefenamic acid can be increased when it is combined with methotrexate.", "severity": 2}
{"drug1": "risperidone", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with risperidone.", "severity": 2}
{"drug1": "theophylline", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with theophylline.", "severity": 2}
{"drug1": "Venetoclax", "drug2": "RANOLAZINE", "interaction_type": 73, "interaction_text": "The serum concentration of RANOLAZINE can be increased when it is combined with Venetoclax.", "severity": 2}
{"drug1": "lithium ion", "drug2": "BENZYDAMINE", "interaction_type": 73, "interaction_text": "The serum concentration of BENZYDAMINE can be increased when it is combined with lithium ion.", "severity": 2}
{"drug1": "etizolam", "drug2": "Dasatinib", "interaction_type": 73, "interaction_text": "The serum concentration of Dasatinib can be increased when it is combined with etizolam.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Netupitant", "interaction_type": 73, "interaction_text": "The serum concentration of Netupitant can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Topiroxostat", "interaction_type": 73, "interaction_text": "The serum concentration of Topiroxostat can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with phenytoin.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Fosaprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Fosaprepitant can be increased when it is combined with trimipramine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "captopril", "interaction_type": 73, "interaction_text": "The serum concentration of captopril can be increased when it is combined with amitriptyline.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Lapatinib.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "vinorelbine", "interaction_type": 73, "interaction_text": "The serum concentration of vinorelbine can be increased when it is combined with Bosutinib.", "severity": 2}
{"drug1": "zolpidem", "drug2": "tolnaftate", "interaction_type": 73, "interaction_text": "The serum concentration of tolnaftate can be increased when it is combined with zolpidem.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Aprepitant", "interaction_type": 73, "interaction_text": "The serum concentration of Aprepitant can be increased when it is combined with mebendazole.", "severity": 2}
{"drug1": "Avanafil", "drug2": "Boceprevir", "interaction_type": 73, "interaction_text": "The serum concentration of Boceprevir can be increased when it is combined with Avanafil.", "severity": 2}
{"drug1": "ouabain", "drug2": "Telithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of Telithromycin can be increased when it is combined with ouabain.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Lercanidipine.", "severity": 2}
{"drug1": "montelukast", "drug2": "Luliconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Luliconazole can be increased when it is combined with montelukast.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Rolapitant", "interaction_type": 73, "interaction_text": "The serum concentration of Rolapitant can be increased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "BOPINDOLOL", "drug2": "nefazodone", "interaction_type": 73, "interaction_text": "The serum concentration of nefazodone can be increased when it is combined with BOPINDOLOL.", "severity": 2}
{"drug1": "pyrazinamide", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with pyrazinamide.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "fusidic acid", "interaction_type": 73, "interaction_text": "The serum concentration of fusidic acid can be increased when it is combined with Gefitinib.", "severity": 2}
{"drug1": "estazolam", "drug2": "SAQUINAVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SAQUINAVIR can be increased when it is combined with estazolam.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "PERINDOPRIL", "interaction_type": 73, "interaction_text": "The serum concentration of PERINDOPRIL can be increased when it is combined with cyclobenzaprine.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "SIMEPREVIR", "interaction_type": 73, "interaction_text": "The serum concentration of SIMEPREVIR can be increased when it is combined with Pazopanib.", "severity": 2}
{"drug1": "Nintedanib", "drug2": "vincristine", "interaction_type": 73, "interaction_text": "The serum concentration of vincristine can be increased when it is combined with Nintedanib.", "severity": 2}
{"drug1": "promazine", "drug2": "pyrimethamine", "interaction_type": 73, "interaction_text": "The serum concentration of pyrimethamine can be increased when it is combined with promazine.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Abiraterone", "interaction_type": 73, "interaction_text": "The serum concentration of Abiraterone can be increased when it is combined with moclobemide.", "severity": 2}
{"drug1": "Deutetrabenazine", "drug2": "osimertinib", "interaction_type": 73, "interaction_text": "The serum concentration of osimertinib can be increased when it is combined with Deutetrabenazine.", "severity": 2}
{"drug1": "cilostazol", "drug2": "oxymetholone", "interaction_type": 73, "interaction_text": "The serum concentration of oxymetholone can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "cilostazol", "drug2": "Armodafinil", "interaction_type": 73, "interaction_text": "The serum concentration of Armodafinil can be increased when it is combined with cilostazol.", "severity": 2}
{"drug1": "ISOSORBIDE MONONITRATE", "drug2": "mifepristone", "interaction_type": 73, "interaction_text": "The serum concentration of mifepristone can be increased when it is combined with ISOSORBIDE MONONITRATE.", "severity": 2}
{"drug1": "desipramine", "drug2": "amprenavir", "interaction_type": 73, "interaction_text": "The serum concentration of amprenavir can be increased when it is combined with desipramine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "josamycin", "interaction_type": 73, "interaction_text": "The serum concentration of josamycin can be increased when it is combined with ALFENTANIL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ivacaftor", "interaction_type": 73, "interaction_text": "The serum concentration of Ivacaftor can be increased when it is combined with Bosentan.", "severity": 2}
{"drug1": "halcinonide", "drug2": "clarithromycin", "interaction_type": 73, "interaction_text": "The serum concentration of clarithromycin can be increased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Darunavir", "interaction_type": 73, "interaction_text": "The serum concentration of Darunavir can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Posaconazole", "interaction_type": 73, "interaction_text": "The serum concentration of Posaconazole can be increased when it is combined with Salmeterol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "prednisone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "prednisone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "flumethasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "medrysone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "paramethasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "amcinonide", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Mometasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "estrone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "budesonide", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "equilin", "drug2": "danazol", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "estrone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "betamethasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "prednisone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "formestane", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "danazol", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "formestane", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "halcinonide", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "paramethasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "danazol", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "prednisone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Mometasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "danazol", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "danazol", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "budesonide", "drug2": "danazol", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "danazol", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "medrysone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "amcinonide", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "amcinonide", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "equilin", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "equilin", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "formestane", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "estrone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "budesonide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "medrysone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "betamethasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "medrysone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "danazol", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "budesonide", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "budesonide", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "halcinonide", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "formestane", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "amcinonide", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "budesonide", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "budesonide", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "equilin", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "estrone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "medrysone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "paramethasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "prednisone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "halcinonide", "drug2": "danazol", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "estrone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "betamethasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "danazol", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "Mometasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Mometasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "difluprednate", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "CORTISONE ACETATE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "medrysone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "loteprednol", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "equilin", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "formestane", "drug2": "danazol", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "equilin", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "halcinonide may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "equilin", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "amcinonide", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "flunisolide", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "budesonide", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "methylprednisolone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "flurandrenolide may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "fludrocortisone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "equilin", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "RIMEXOLONE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "prednisone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "medrysone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "dexamethasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "loteprednol", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "amcinonide may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "DEFLAZACORT may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "hydrocortisone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Clobetasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "loteprednol may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "difluprednate may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "FLUOCORTOLONE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "danazol", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "estrone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "estrone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "prednisone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "flunisolide may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "prednisone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "paramethasone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "estrone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "diflorasone", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "diflorasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "diflorasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "estrone", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "estrone may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "triamcinolone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "formestane", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "FLUTICASONE PROPIONATE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Tixocortol may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "formestane", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "formestane", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Fluprednidene may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "budesonide", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "budesonide may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "DESONIDE may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "medrysone", "drug2": "oxymetholone", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of oxymetholone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Ciclesonide may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "Fluticasone furoate may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "Estrone sulfate may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "Halobetasol may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "flumethasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "flumethasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "medrysone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "medrysone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "danazol", "interaction_type": 74, "interaction_text": "Dehydroepiandrosterone may increase the fluid retaining activities of danazol.", "severity": 2}
{"drug1": "equilin", "drug2": "fluoxymesterone", "interaction_type": 74, "interaction_text": "equilin may increase the fluid retaining activities of fluoxymesterone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "fluocinonide may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "desoximetasone may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "formestane", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "formestane may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "paramethasone", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "paramethasone may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "methyltestosterone", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of methyltestosterone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "stanozolol", "interaction_type": 74, "interaction_text": "CLOBETASOL PROPIONATE may increase the fluid retaining activities of stanozolol.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "testosterone propionate", "interaction_type": 74, "interaction_text": "CLOCORTOLONE may increase the fluid retaining activities of testosterone propionate.", "severity": 2}
{"drug1": "prednisone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "prednisone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "OXANDROLONE", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of OXANDROLONE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "testosterone", "interaction_type": 74, "interaction_text": "PREDNICARBATE may increase the fluid retaining activities of testosterone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "NANDROLONE DECANOATE", "interaction_type": 74, "interaction_text": "alclometasone may increase the fluid retaining activities of NANDROLONE DECANOATE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "nafcillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "captopril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dasabuvir", "interaction_type": 75, "interaction_text": "The serum concentration of Dasabuvir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "quinapril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Myostibin", "interaction_type": 75, "interaction_text": "The serum concentration of Myostibin can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Ombitasvir", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Ombitasvir.", "severity": 2}
{"drug1": "efavirenz", "drug2": "xylometazoline", "interaction_type": 75, "interaction_text": "The serum concentration of xylometazoline can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Lanreotide", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Lanreotide.", "severity": 2}
{"drug1": "amprenavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "enflurane", "interaction_type": 75, "interaction_text": "The serum concentration of enflurane can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with pyridostigmine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with mifepristone.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "orlistat", "drug2": "Paricalcitol", "interaction_type": 75, "interaction_text": "The serum concentration of Paricalcitol can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "quinapril", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "triamcinolone", "interaction_type": 75, "interaction_text": "The serum concentration of triamcinolone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nicardipine", "interaction_type": 75, "interaction_text": "The serum concentration of nicardipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Pimecrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Pimecrolimus can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "testosterone", "interaction_type": 75, "interaction_text": "The serum concentration of testosterone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clorazepate", "interaction_type": 75, "interaction_text": "The serum concentration of clorazepate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "pyrazinamide", "interaction_type": 75, "interaction_text": "The serum concentration of pyrazinamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "amobarbital", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "azlocillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cabergoline", "interaction_type": 75, "interaction_text": "The serum concentration of cabergoline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "alclometasone", "interaction_type": 75, "interaction_text": "The serum concentration of alclometasone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "methicillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tioconazole", "interaction_type": 75, "interaction_text": "The serum concentration of tioconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Enasidenib", "interaction_type": 75, "interaction_text": "The serum concentration of Enasidenib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "azlocillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "Lisdexamfetamine", "interaction_type": 75, "interaction_text": "The serum concentration of Lisdexamfetamine can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "primidone", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "primidone", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "eperisone", "interaction_type": 75, "interaction_text": "The serum concentration of eperisone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ambroxol", "interaction_type": 75, "interaction_text": "The serum concentration of ambroxol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Palonosetron", "interaction_type": 75, "interaction_text": "The serum concentration of Palonosetron can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "meprobamate", "interaction_type": 75, "interaction_text": "The serum concentration of meprobamate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mirtazapine", "interaction_type": 75, "interaction_text": "The serum concentration of mirtazapine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "timolol", "interaction_type": 75, "interaction_text": "The serum concentration of timolol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "indapamide", "interaction_type": 75, "interaction_text": "The serum concentration of indapamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "OXCARBAZEPINE", "interaction_type": 75, "interaction_text": "The serum concentration of OXCARBAZEPINE can be decreased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Avanafil", "interaction_type": 75, "interaction_text": "The serum concentration of Avanafil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "zopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of zopiclone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "cisapride", "interaction_type": 75, "interaction_text": "The serum concentration of cisapride can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "oxymorphone", "interaction_type": 75, "interaction_text": "The serum concentration of oxymorphone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "chenodeoxycholic acid", "interaction_type": 75, "interaction_text": "The serum concentration of chenodeoxycholic acid can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Liotrix", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with Liotrix.", "severity": 2}
{"drug1": "osimertinib", "drug2": "guanabenz", "interaction_type": 75, "interaction_text": "The serum concentration of guanabenz can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with paramethasone.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "penicillin g", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "podophyllotoxin", "interaction_type": 75, "interaction_text": "The serum concentration of podophyllotoxin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "moclobemide", "interaction_type": 75, "interaction_text": "The serum concentration of moclobemide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "orphenadrine", "interaction_type": 75, "interaction_text": "The serum concentration of orphenadrine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Baricitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Baricitinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "finasteride", "interaction_type": 75, "interaction_text": "The serum concentration of finasteride can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "estazolam", "interaction_type": 75, "interaction_text": "The serum concentration of estazolam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clarithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of clarithromycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "topiramate", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenytoin", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dantrolene", "interaction_type": 75, "interaction_text": "The serum concentration of dantrolene can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Halofantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Halofantrine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "oxacillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Lumiracoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Lumiracoxib can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "felbamate", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Aluminium", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Ecabet", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "famotidine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "chloroquine", "drug2": "LUCANTHONE", "interaction_type": 75, "interaction_text": "The serum concentration of LUCANTHONE can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rotigotine", "interaction_type": 75, "interaction_text": "The serum concentration of Rotigotine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "clofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of clofibrate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "astemizole", "interaction_type": 75, "interaction_text": "The serum concentration of astemizole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "quinapril", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "promethazine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "primidone", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "primidone", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "flumethasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with flumethasone.", "severity": 2}
{"drug1": "mitotane", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "tolfenamic acid", "interaction_type": 75, "interaction_text": "The serum concentration of tolfenamic acid can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "mitotane", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "propofol", "interaction_type": 75, "interaction_text": "The serum concentration of propofol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "trimethoprim", "interaction_type": 75, "interaction_text": "The serum concentration of trimethoprim can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "budesonide", "interaction_type": 75, "interaction_text": "The serum concentration of budesonide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ampicillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nilutamide", "interaction_type": 75, "interaction_text": "The serum concentration of nilutamide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "isradipine", "interaction_type": 75, "interaction_text": "The serum concentration of isradipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "MEPHENTERMINE", "interaction_type": 75, "interaction_text": "The serum concentration of MEPHENTERMINE can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "tolperisone", "interaction_type": 75, "interaction_text": "The serum concentration of tolperisone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "enalapril", "interaction_type": 75, "interaction_text": "The serum concentration of enalapril can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "efavirenz", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "primidone", "interaction_type": 75, "interaction_text": "The serum concentration of primidone can be decreased when it is combined with Levoleucovorin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "LISURIDE", "interaction_type": 75, "interaction_text": "The serum concentration of LISURIDE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "thiamylal", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cocaine", "interaction_type": 75, "interaction_text": "The serum concentration of cocaine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tiagabine", "interaction_type": 75, "interaction_text": "The serum concentration of tiagabine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "thalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of thalidomide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "mifepristone", "interaction_type": 75, "interaction_text": "The serum concentration of mifepristone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "loperamide", "interaction_type": 75, "interaction_text": "The serum concentration of loperamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "risperidone", "interaction_type": 75, "interaction_text": "The serum concentration of risperidone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nateglinide", "interaction_type": 75, "interaction_text": "The serum concentration of nateglinide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "indinavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nevirapine", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "pergolide", "interaction_type": 75, "interaction_text": "The serum concentration of pergolide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ifosfamide", "interaction_type": 75, "interaction_text": "The serum concentration of ifosfamide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "trifluoperazine", "interaction_type": 75, "interaction_text": "The serum concentration of trifluoperazine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "Aluminium", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "doxepin", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "doxepin", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "erythromycin", "interaction_type": 75, "interaction_text": "The serum concentration of erythromycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "osimertinib", "drug2": "duloxetine", "interaction_type": 75, "interaction_text": "The serum concentration of duloxetine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Isavuconazonium", "interaction_type": 75, "interaction_text": "The serum concentration of Isavuconazonium can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "niclosamide", "interaction_type": 75, "interaction_text": "The serum concentration of niclosamide can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ipratropium", "interaction_type": 75, "interaction_text": "The serum concentration of ipratropium can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE MONONITRATE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "piperazine", "interaction_type": 75, "interaction_text": "The serum concentration of piperazine can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "epinastine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "amobarbital", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "acetazolamide", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with acetazolamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "terconazole", "interaction_type": 75, "interaction_text": "The serum concentration of terconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clotrimazole", "interaction_type": 75, "interaction_text": "The serum concentration of clotrimazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "epinastine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "argatroban", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE MONONITRATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "methicillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of clofibrate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "astemizole", "interaction_type": 75, "interaction_text": "The serum concentration of astemizole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Liotrix", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Liotrix.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nimesulide", "interaction_type": 75, "interaction_text": "The serum concentration of nimesulide can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "piperazine", "interaction_type": 75, "interaction_text": "The serum concentration of piperazine can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "orlistat", "drug2": "OXCARBAZEPINE", "interaction_type": 75, "interaction_text": "The serum concentration of OXCARBAZEPINE can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "etoposide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with etoposide.", "severity": 2}
{"drug1": "mitotane", "drug2": "paramethasone", "interaction_type": 75, "interaction_text": "The serum concentration of paramethasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "osimertinib", "drug2": "STIRIPENTOL", "interaction_type": 75, "interaction_text": "The serum concentration of STIRIPENTOL can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ciclesonide", "interaction_type": 75, "interaction_text": "The serum concentration of Ciclesonide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with Olsalazine.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "pentoxifylline", "interaction_type": 75, "interaction_text": "The serum concentration of pentoxifylline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "clenbuterol", "interaction_type": 75, "interaction_text": "The serum concentration of clenbuterol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "isoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of isoflurane can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with sulfasalazine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "reserpine", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "quinapril", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "phenytoin", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "orlistat", "drug2": "METHSUXIMIDE", "interaction_type": 75, "interaction_text": "The serum concentration of METHSUXIMIDE can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Paricalcitol", "interaction_type": 75, "interaction_text": "The serum concentration of Paricalcitol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "tinidazole", "interaction_type": 75, "interaction_text": "The serum concentration of tinidazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Repaglinide", "interaction_type": 75, "interaction_text": "The serum concentration of Repaglinide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Flubendazole", "interaction_type": 75, "interaction_text": "The serum concentration of Flubendazole can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Cladribine", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with Cladribine.", "severity": 2}
{"drug1": "methadone", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with methadone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Deferasirox", "interaction_type": 75, "interaction_text": "The serum concentration of Deferasirox can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with loteprednol.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "codeine", "interaction_type": 75, "interaction_text": "The serum concentration of codeine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "propoxyphene", "interaction_type": 75, "interaction_text": "The serum concentration of propoxyphene can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "DEFLAZACORT", "interaction_type": 75, "interaction_text": "The serum concentration of DEFLAZACORT can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "penbutolol", "interaction_type": 75, "interaction_text": "The serum concentration of penbutolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "barnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of barnidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nadolol", "interaction_type": 75, "interaction_text": "The serum concentration of nadolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Octreotide", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Octreotide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ampicillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with norfloxacin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Frovatriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Frovatriptan can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "cholic acid", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with cholic acid.", "severity": 2}
{"drug1": "argatroban", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with clofibrate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "disulfiram", "interaction_type": 75, "interaction_text": "The serum concentration of disulfiram can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "VERAPAMIL", "interaction_type": 75, "interaction_text": "The serum concentration of VERAPAMIL can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "betaxolol", "interaction_type": 75, "interaction_text": "The serum concentration of betaxolol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "podophyllotoxin", "interaction_type": 75, "interaction_text": "The serum concentration of podophyllotoxin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Naftifine", "interaction_type": 75, "interaction_text": "The serum concentration of Naftifine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "doxazosin", "interaction_type": 75, "interaction_text": "The serum concentration of doxazosin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "osimertinib", "drug2": "ranitidine", "interaction_type": 75, "interaction_text": "The serum concentration of ranitidine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "lisinopril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "thiamylal", "interaction_type": 75, "interaction_text": "The serum concentration of thiamylal can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "desipramine", "interaction_type": 75, "interaction_text": "The serum concentration of desipramine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Indacaterol", "interaction_type": 75, "interaction_text": "The serum concentration of Indacaterol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "modafinil", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vecuronium", "interaction_type": 75, "interaction_text": "The serum concentration of Vecuronium can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "trientine", "interaction_type": 75, "interaction_text": "The serum concentration of trientine can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "furosemide", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with furosemide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Ecabet", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "estradiol", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with estradiol.", "severity": 2}
{"drug1": "mitotane", "drug2": "Aliskiren", "interaction_type": 75, "interaction_text": "The serum concentration of Aliskiren can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "liothyronine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with liothyronine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "phenytoin", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Trometamol", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "quinapril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Apixaban", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "piperacillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "primidone", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Aluminium", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Paritaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Paritaprevir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Almasilate", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "colchicine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with colchicine.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Conivaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Conivaptan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "BISOPROLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BISOPROLOL can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "IVERMECTIN", "interaction_type": 75, "interaction_text": "The serum concentration of IVERMECTIN can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "CARTEOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of CARTEOLOL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "formoterol", "interaction_type": 75, "interaction_text": "The serum concentration of formoterol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "amikacin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with amikacin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Neratinib", "interaction_type": 75, "interaction_text": "The serum concentration of Neratinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "orlistat", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "SUFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of SUFENTANIL can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Darunavir", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "SERATRODAST", "interaction_type": 75, "interaction_text": "The serum concentration of SERATRODAST can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ketobemidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ketobemidone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Eletriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Eletriptan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zaltoprofen", "interaction_type": 75, "interaction_text": "The serum concentration of zaltoprofen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Aceclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of Aceclofenac can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "pantoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of pantoprazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dehydroepiandrosterone", "interaction_type": 75, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Aluminium", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "AZATADINE", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with AZATADINE.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "bleomycin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with bleomycin.", "severity": 2}
{"drug1": "Liotrix", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Liotrix.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Caspofungin", "interaction_type": 75, "interaction_text": "The serum concentration of Caspofungin can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "benztropine", "interaction_type": 75, "interaction_text": "The serum concentration of benztropine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "perphenazine", "interaction_type": 75, "interaction_text": "The serum concentration of perphenazine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "dacarbazine", "interaction_type": 75, "interaction_text": "The serum concentration of dacarbazine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "mitotane", "drug2": "letrozole", "interaction_type": 75, "interaction_text": "The serum concentration of letrozole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "topiramate", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Retapamulin", "interaction_type": 75, "interaction_text": "The serum concentration of Retapamulin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "desipramine", "interaction_type": 75, "interaction_text": "The serum concentration of desipramine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ketamine", "interaction_type": 75, "interaction_text": "The serum concentration of ketamine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "budesonide", "interaction_type": 75, "interaction_text": "The serum concentration of budesonide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "Lisdexamfetamine", "interaction_type": 75, "interaction_text": "The serum concentration of Lisdexamfetamine can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "magnesium ion", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with magnesium ion.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Prasugrel", "interaction_type": 75, "interaction_text": "The serum concentration of Prasugrel can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Imidafenacin", "interaction_type": 75, "interaction_text": "The serum concentration of Imidafenacin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Alogliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Alogliptin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Silodosin", "interaction_type": 75, "interaction_text": "The serum concentration of Silodosin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "letrozole", "interaction_type": 75, "interaction_text": "The serum concentration of letrozole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Levobupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Levobupivacaine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROXYPROGESTERONE CAPROATE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "BISOPROLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BISOPROLOL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "amodiaquine", "interaction_type": 75, "interaction_text": "The serum concentration of amodiaquine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "mitotane", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE MONONITRATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "mitotane", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "methenamine", "drug2": "Amfepramone", "interaction_type": 75, "interaction_text": "The serum concentration of Amfepramone can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "mitotane", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "penicillin v", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mesalamine", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with mesalamine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "antipyrine", "interaction_type": 75, "interaction_text": "The serum concentration of antipyrine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "allylestrenol", "interaction_type": 75, "interaction_text": "The serum concentration of allylestrenol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "liothyronine", "interaction_type": 75, "interaction_text": "The serum concentration of liothyronine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "topiramate", "interaction_type": 75, "interaction_text": "The serum concentration of topiramate can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "malathion", "interaction_type": 75, "interaction_text": "The serum concentration of malathion can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "mitotane", "drug2": "roxithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of roxithromycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Artemether", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "primidone", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "Almasilate", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "efavirenz", "drug2": "tolfenamic acid", "interaction_type": 75, "interaction_text": "The serum concentration of tolfenamic acid can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ambrisentan", "interaction_type": 75, "interaction_text": "The serum concentration of Ambrisentan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "VERAPAMIL", "interaction_type": 75, "interaction_text": "The serum concentration of VERAPAMIL can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Lumiracoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Lumiracoxib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clindamycin", "interaction_type": 75, "interaction_text": "The serum concentration of clindamycin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "metrizamide", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with metrizamide.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "reserpine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "orlistat", "drug2": "clonazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clonazepam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Salmeterol", "interaction_type": 75, "interaction_text": "The serum concentration of Salmeterol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "pilocarpine", "interaction_type": 75, "interaction_text": "The serum concentration of pilocarpine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "caffeine", "interaction_type": 75, "interaction_text": "The serum concentration of caffeine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "azithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of azithromycin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dofetilide", "interaction_type": 75, "interaction_text": "The serum concentration of Dofetilide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Polaprezinc", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Polaprezinc.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "nabumetone", "interaction_type": 75, "interaction_text": "The serum concentration of nabumetone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with isoproterenol.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "piperacillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "famciclovir", "interaction_type": 75, "interaction_text": "The serum concentration of famciclovir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Levocetirizine", "interaction_type": 75, "interaction_text": "The serum concentration of Levocetirizine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "penicillin v", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "liothyronine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with liothyronine.", "severity": 2}
{"drug1": "netilmicin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with netilmicin.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Bosentan", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "fluconazole", "drug2": "losartan", "interaction_type": 75, "interaction_text": "The serum concentration of losartan can be decreased when it is combined with fluconazole.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with desoximetasone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "methicillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "cephradine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with cephradine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "methyltestosterone", "interaction_type": 75, "interaction_text": "The serum concentration of methyltestosterone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "primidone", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "famotidine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "enalapril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Mephobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Mephobarbital can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "donepezil", "interaction_type": 75, "interaction_text": "The serum concentration of donepezil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "oxazepam", "interaction_type": 75, "interaction_text": "The serum concentration of oxazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clofazimine", "interaction_type": 75, "interaction_text": "The serum concentration of clofazimine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Eslicarbazepine acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Eslicarbazepine acetate can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "STIRIPENTOL", "interaction_type": 75, "interaction_text": "The serum concentration of STIRIPENTOL can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "orlistat", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "LUCANTHONE", "interaction_type": 75, "interaction_text": "The serum concentration of LUCANTHONE can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "epinastine", "interaction_type": 75, "interaction_text": "The serum concentration of epinastine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tretinoin", "interaction_type": 75, "interaction_text": "The serum concentration of tretinoin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ropinirole", "interaction_type": 75, "interaction_text": "The serum concentration of ropinirole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dicumarol", "interaction_type": 75, "interaction_text": "The serum concentration of dicumarol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "metoprolol", "interaction_type": 75, "interaction_text": "The serum concentration of metoprolol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sulfisoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfisoxazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Iloperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Iloperidone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "thiopental", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "rasagiline", "interaction_type": 75, "interaction_text": "The serum concentration of rasagiline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "azlocillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "epinastine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "amprenavir", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "HEROIN", "interaction_type": 75, "interaction_text": "The serum concentration of HEROIN can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "PYRVINIUM", "interaction_type": 75, "interaction_text": "The serum concentration of PYRVINIUM can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 75, "interaction_text": "The serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "orlistat", "drug2": "Doxercalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of Doxercalciferol can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "ramipril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "ramipril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Mephobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Mephobarbital can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "KETAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of KETAZOLAM can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "CORTISONE ACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of CORTISONE ACETATE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "quazepam", "interaction_type": 75, "interaction_text": "The serum concentration of quazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "prazepam", "interaction_type": 75, "interaction_text": "The serum concentration of prazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "indinavir", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amiodarone", "interaction_type": 75, "interaction_text": "The serum concentration of amiodarone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "5-Fluorouracil", "interaction_type": 75, "interaction_text": "The serum concentration of 5-Fluorouracil can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "astemizole", "interaction_type": 75, "interaction_text": "The serum concentration of astemizole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of clofibrate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "AMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of AMPHETAMINE can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "streptozocin", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with streptozocin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "amobarbital", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "nicotine", "interaction_type": 75, "interaction_text": "The serum concentration of nicotine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Cevimeline", "interaction_type": 75, "interaction_text": "The serum concentration of Cevimeline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "flunisolide", "interaction_type": 75, "interaction_text": "The serum concentration of flunisolide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "secobarbital", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "streptozocin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with streptozocin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "theophylline", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with theophylline.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Fulvestrant", "interaction_type": 75, "interaction_text": "The serum concentration of Fulvestrant can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Delafloxacin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Delafloxacin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "zalcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of zalcitabine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Reboxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Reboxetine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "methyltestosterone", "interaction_type": 75, "interaction_text": "The serum concentration of methyltestosterone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "temazepam", "interaction_type": 75, "interaction_text": "The serum concentration of temazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "perphenazine", "interaction_type": 75, "interaction_text": "The serum concentration of perphenazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "colchicine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with colchicine.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with vinblastine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "KETAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of KETAZOLAM can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "quazepam", "interaction_type": 75, "interaction_text": "The serum concentration of quazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "prazepam", "interaction_type": 75, "interaction_text": "The serum concentration of prazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "BISMUTH SUBSALICYLATE", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with BISMUTH SUBSALICYLATE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "mitotane", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "topotecan", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with topotecan.", "severity": 2}
{"drug1": "loratadine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with loratadine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "selegiline", "interaction_type": 75, "interaction_text": "The serum concentration of selegiline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "loratadine", "interaction_type": 75, "interaction_text": "The serum concentration of loratadine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dexlansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of dexlansoprazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "thiotepa", "interaction_type": 75, "interaction_text": "The serum concentration of thiotepa can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "TASOSARTAN", "interaction_type": 75, "interaction_text": "The serum concentration of TASOSARTAN can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dopamine", "interaction_type": 75, "interaction_text": "The serum concentration of dopamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clonazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clonazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "oxybutynin", "interaction_type": 75, "interaction_text": "The serum concentration of oxybutynin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Midostaurin", "interaction_type": 75, "interaction_text": "The serum concentration of Midostaurin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "primidone", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "enalapril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "oxybutynin", "interaction_type": 75, "interaction_text": "The serum concentration of oxybutynin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nicotine", "interaction_type": 75, "interaction_text": "The serum concentration of nicotine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Cevimeline", "interaction_type": 75, "interaction_text": "The serum concentration of Cevimeline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ampicillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "flunisolide", "interaction_type": 75, "interaction_text": "The serum concentration of flunisolide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Levobupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Levobupivacaine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "chlorpropamide", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpropamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "galanthamine", "interaction_type": 75, "interaction_text": "The serum concentration of galanthamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "losartan", "interaction_type": 75, "interaction_text": "The serum concentration of losartan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "mitotane", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "enalapril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "osimertinib", "drug2": "OXTRIPHYLLINE", "interaction_type": 75, "interaction_text": "The serum concentration of OXTRIPHYLLINE can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "prochlorperazine", "interaction_type": 75, "interaction_text": "The serum concentration of prochlorperazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "pyrazinamide", "interaction_type": 75, "interaction_text": "The serum concentration of pyrazinamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ipratropium", "interaction_type": 75, "interaction_text": "The serum concentration of ipratropium can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Pimecrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Pimecrolimus can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "quinapril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "mitotane", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Voxilaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Voxilaprevir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "thiamylal", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "mitotane", "drug2": "epinastine", "interaction_type": 75, "interaction_text": "The serum concentration of epinastine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "tretinoin", "interaction_type": 75, "interaction_text": "The serum concentration of tretinoin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "dolasetron", "interaction_type": 75, "interaction_text": "The serum concentration of dolasetron can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "tetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of tetracycline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "cilnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of cilnidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Azelnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Azelnidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Benidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Benidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Lacidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lacidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Efonidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Efonidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "manidipine", "interaction_type": 75, "interaction_text": "The serum concentration of manidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "eperisone", "interaction_type": 75, "interaction_text": "The serum concentration of eperisone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "enoxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with enoxacin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Almasilate", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Avanafil", "interaction_type": 75, "interaction_text": "The serum concentration of Avanafil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Almasilate", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Perospirone", "interaction_type": 75, "interaction_text": "The serum concentration of Perospirone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "dichlorphenamide", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with dichlorphenamide.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with amiodarone.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Levobupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Levobupivacaine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "SERTINDOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SERTINDOLE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with dextroamphetamine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE DINITRATE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "granisetron", "interaction_type": 75, "interaction_text": "The serum concentration of granisetron can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "folic acid", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with folic acid.", "severity": 2}
{"drug1": "felbamate", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Pinaverium", "interaction_type": 75, "interaction_text": "The serum concentration of Pinaverium can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "betaxolol", "interaction_type": 75, "interaction_text": "The serum concentration of betaxolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with ETHACRYNIC ACID.", "severity": 2}
{"drug1": "topiramate", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Eszopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of Eszopiclone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "liothyronine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with liothyronine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with flunisolide.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "methicillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sulfinpyrazone", "interaction_type": 75, "interaction_text": "The serum concentration of sulfinpyrazone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "methicillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "betaxolol", "interaction_type": 75, "interaction_text": "The serum concentration of betaxolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "zolmitriptan", "interaction_type": 75, "interaction_text": "The serum concentration of zolmitriptan can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "diazoxide", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with diazoxide.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Pimecrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Pimecrolimus can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "promethazine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Bosentan", "interaction_type": 75, "interaction_text": "The serum concentration of Bosentan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "promethazine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Aceclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of Aceclofenac can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "zaltoprofen", "interaction_type": 75, "interaction_text": "The serum concentration of zaltoprofen can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with cholic acid.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "argatroban", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "primidone", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "amiodarone", "interaction_type": 75, "interaction_text": "The serum concentration of amiodarone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "losartan", "interaction_type": 75, "interaction_text": "The serum concentration of losartan can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "chlorpheniramine", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpheniramine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Pregabalin", "interaction_type": 75, "interaction_text": "The serum concentration of Pregabalin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ranitidine", "interaction_type": 75, "interaction_text": "The serum concentration of ranitidine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vardenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Vardenafil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dorzolamide", "interaction_type": 75, "interaction_text": "The serum concentration of dorzolamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ruxolitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ruxolitinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "ramipril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clorazepate", "interaction_type": 75, "interaction_text": "The serum concentration of clorazepate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "penicillin v", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "ampicillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "triamcinolone", "interaction_type": 75, "interaction_text": "The serum concentration of triamcinolone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with Gatifloxacin.", "severity": 2}
{"drug1": "trazodone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with trazodone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with pyridostigmine.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "desipramine", "interaction_type": 75, "interaction_text": "The serum concentration of desipramine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "glimepiride", "interaction_type": 75, "interaction_text": "The serum concentration of glimepiride can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cabergoline", "interaction_type": 75, "interaction_text": "The serum concentration of cabergoline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "alclometasone", "interaction_type": 75, "interaction_text": "The serum concentration of alclometasone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "benztropine", "interaction_type": 75, "interaction_text": "The serum concentration of benztropine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ziprasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ziprasidone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Deferasirox", "interaction_type": 75, "interaction_text": "The serum concentration of Deferasirox can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "hexylresorcinol", "interaction_type": 75, "interaction_text": "The serum concentration of hexylresorcinol can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with Lisdexamfetamine.", "severity": 2}
{"drug1": "primidone", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "chloroquine", "drug2": "PYRVINIUM", "interaction_type": 75, "interaction_text": "The serum concentration of PYRVINIUM can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "piperacillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "dicumarol", "interaction_type": 75, "interaction_text": "The serum concentration of dicumarol can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "tobramycin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with tobramycin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "penicillin v", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Aliskiren", "interaction_type": 75, "interaction_text": "The serum concentration of Aliskiren can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clarithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of clarithromycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Copanlisib", "interaction_type": 75, "interaction_text": "The serum concentration of Copanlisib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "COPPER", "drug2": "l-ascorbic acid", "interaction_type": 75, "interaction_text": "The serum concentration of l-ascorbic acid can be decreased when it is combined with COPPER.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "famciclovir", "interaction_type": 75, "interaction_text": "The serum concentration of famciclovir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Neratinib", "interaction_type": 75, "interaction_text": "The serum concentration of Neratinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Conivaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Conivaptan can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "oxaliplatin", "interaction_type": 75, "interaction_text": "The serum concentration of oxaliplatin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "chloroxylenol", "interaction_type": 75, "interaction_text": "The serum concentration of chloroxylenol can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Spectinomycin.", "severity": 2}
{"drug1": "Trometamol", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "ritonavir", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "chloroquine", "drug2": "oxamniquine", "interaction_type": 75, "interaction_text": "The serum concentration of oxamniquine can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "captopril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "cefdinir", "interaction_type": 75, "interaction_text": "The serum concentration of cefdinir can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "dapsone", "interaction_type": 75, "interaction_text": "The serum concentration of dapsone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with clofibrate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "theobromine", "interaction_type": 75, "interaction_text": "The serum concentration of theobromine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "mifepristone", "interaction_type": 75, "interaction_text": "The serum concentration of mifepristone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "topotecan", "interaction_type": 75, "interaction_text": "The serum concentration of topotecan can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Voxilaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Voxilaprevir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Midostaurin", "interaction_type": 75, "interaction_text": "The serum concentration of Midostaurin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Doripenem", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Doripenem.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "lisinopril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "orlistat", "drug2": "eperisone", "interaction_type": 75, "interaction_text": "The serum concentration of eperisone can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Bosentan", "drug2": "prochlorperazine", "interaction_type": 75, "interaction_text": "The serum concentration of prochlorperazine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "benazepril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "primidone", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Sitagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Sitagliptin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Ecabet", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Bazedoxifene", "interaction_type": 75, "interaction_text": "The serum concentration of Bazedoxifene can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rimonabant", "interaction_type": 75, "interaction_text": "The serum concentration of Rimonabant can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Aluminium", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "chlordiazepoxide", "interaction_type": 75, "interaction_text": "The serum concentration of chlordiazepoxide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "montelukast", "interaction_type": 75, "interaction_text": "The serum concentration of montelukast can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "nifedipine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with nifedipine.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "epinastine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "pilocarpine", "interaction_type": 75, "interaction_text": "The serum concentration of pilocarpine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "PRIMAQUINE", "interaction_type": 75, "interaction_text": "The serum concentration of PRIMAQUINE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "gentamicin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with gentamicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "enalapril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "primidone", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Perampanel", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "mycophenolate mofetil", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolate mofetil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "midazolam", "interaction_type": 75, "interaction_text": "The serum concentration of midazolam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Deutetrabenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Deutetrabenazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "omeprazole", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "trientine", "drug2": "Iron sucrose", "interaction_type": 75, "interaction_text": "The serum concentration of Iron sucrose can be decreased when it is combined with trientine.", "severity": 2}
{"drug1": "amcinonide", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "topiramate", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "mitotane", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "osimertinib", "drug2": "rasagiline", "interaction_type": 75, "interaction_text": "The serum concentration of rasagiline can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "penicillin g", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ranitidine", "interaction_type": 75, "interaction_text": "The serum concentration of ranitidine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "chlorzoxazone", "interaction_type": 75, "interaction_text": "The serum concentration of chlorzoxazone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "sulfadiazine", "interaction_type": 75, "interaction_text": "The serum concentration of sulfadiazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "mefloquine", "interaction_type": 75, "interaction_text": "The serum concentration of mefloquine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rifampicin", "interaction_type": 75, "interaction_text": "The serum concentration of Rifampicin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "nateglinide", "interaction_type": 75, "interaction_text": "The serum concentration of nateglinide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "amobarbital", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "mitotane", "drug2": "risperidone", "interaction_type": 75, "interaction_text": "The serum concentration of risperidone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Almasilate", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Ketobemidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ketobemidone can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "orlistat", "drug2": "Calcipotriol", "interaction_type": 75, "interaction_text": "The serum concentration of Calcipotriol can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Eplerenone", "interaction_type": 75, "interaction_text": "The serum concentration of Eplerenone can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "difluprednate", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with difluprednate.", "severity": 2}
{"drug1": "norethindrone", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Rupatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Rupatadine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "thiabendazole", "interaction_type": 75, "interaction_text": "The serum concentration of thiabendazole can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Velpatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Velpatasvir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "benazepril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "orlistat", "drug2": "phytonadione", "interaction_type": 75, "interaction_text": "The serum concentration of phytonadione can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "orlistat", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "osimertinib", "drug2": "menadione", "interaction_type": 75, "interaction_text": "The serum concentration of menadione can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Fesoterodine", "interaction_type": 75, "interaction_text": "The serum concentration of Fesoterodine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "quinapril", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dopamine", "interaction_type": 75, "interaction_text": "The serum concentration of dopamine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Fluticasone furoate", "interaction_type": 75, "interaction_text": "The serum concentration of Fluticasone furoate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "maprotiline", "interaction_type": 75, "interaction_text": "The serum concentration of maprotiline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "penicillin v", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "penicillin v", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "orlistat", "drug2": "meprobamate", "interaction_type": 75, "interaction_text": "The serum concentration of meprobamate can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "suramin", "interaction_type": 75, "interaction_text": "The serum concentration of suramin can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "chlorpheniramine", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpheniramine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "miconazole", "interaction_type": 75, "interaction_text": "The serum concentration of miconazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "arsenic trioxide", "interaction_type": 75, "interaction_text": "The serum concentration of arsenic trioxide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Enasidenib", "interaction_type": 75, "interaction_text": "The serum concentration of Enasidenib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "NATAMYCIN", "interaction_type": 75, "interaction_text": "The serum concentration of NATAMYCIN can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "vinblastine", "interaction_type": 75, "interaction_text": "The serum concentration of vinblastine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dasabuvir", "interaction_type": 75, "interaction_text": "The serum concentration of Dasabuvir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "PRIMAQUINE", "interaction_type": 75, "interaction_text": "The serum concentration of PRIMAQUINE can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "osimertinib", "drug2": "pentoxifylline", "interaction_type": 75, "interaction_text": "The serum concentration of pentoxifylline can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "primidone", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Benidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Benidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Safinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Safinamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "glucosamine", "interaction_type": 75, "interaction_text": "The serum concentration of glucosamine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Efonidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Efonidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "orlistat", "drug2": "riluzole", "interaction_type": 75, "interaction_text": "The serum concentration of riluzole can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dehydroepiandrosterone", "interaction_type": 75, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "gemfibrozil", "interaction_type": 75, "interaction_text": "The serum concentration of gemfibrozil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Metipranolol", "interaction_type": 75, "interaction_text": "The serum concentration of Metipranolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "felodipine", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with felodipine.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Rufinamide.", "severity": 2}
{"drug1": "trandolapril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "malathion", "interaction_type": 75, "interaction_text": "The serum concentration of malathion can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cisapride", "interaction_type": 75, "interaction_text": "The serum concentration of cisapride can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "IVERMECTIN", "interaction_type": 75, "interaction_text": "The serum concentration of IVERMECTIN can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Bosentan", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "argatroban", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "niclosamide", "interaction_type": 75, "interaction_text": "The serum concentration of niclosamide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Darunavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "folic acid", "interaction_type": 75, "interaction_text": "The serum concentration of folic acid can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "orlistat", "drug2": "topiramate", "interaction_type": 75, "interaction_text": "The serum concentration of topiramate can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "primidone", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "argatroban", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "glimepiride", "interaction_type": 75, "interaction_text": "The serum concentration of glimepiride can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Letermovir", "interaction_type": 75, "interaction_text": "The serum concentration of Letermovir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Sodium phosphate monobasic", "interaction_type": 75, "interaction_text": "The serum concentration of Sodium phosphate monobasic can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "orlistat", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "azlocillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "galanthamine", "interaction_type": 75, "interaction_text": "The serum concentration of galanthamine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Perampanel", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Grazoprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Grazoprevir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dolasetron", "interaction_type": 75, "interaction_text": "The serum concentration of dolasetron can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tretinoin", "interaction_type": 75, "interaction_text": "The serum concentration of tretinoin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "caffeine", "interaction_type": 75, "interaction_text": "The serum concentration of caffeine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "MAGNESIUM SULFATE", "interaction_type": 75, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "IMIQUIMOD", "interaction_type": 75, "interaction_text": "The serum concentration of IMIQUIMOD can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "trimipramine", "interaction_type": 75, "interaction_text": "The serum concentration of trimipramine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "penicillin g", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Ecabet", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "captopril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "penicillin g", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "letrozole", "interaction_type": 75, "interaction_text": "The serum concentration of letrozole can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "mitotane", "drug2": "argatroban", "interaction_type": 75, "interaction_text": "The serum concentration of argatroban can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ethanol", "interaction_type": 75, "interaction_text": "The serum concentration of ethanol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "isradipine", "interaction_type": 75, "interaction_text": "The serum concentration of isradipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ADINAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of ADINAZOLAM can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "antipyrine", "interaction_type": 75, "interaction_text": "The serum concentration of antipyrine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "sibutramine", "interaction_type": 75, "interaction_text": "The serum concentration of sibutramine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "gliclazide", "interaction_type": 75, "interaction_text": "The serum concentration of gliclazide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tolbutamide", "interaction_type": 75, "interaction_text": "The serum concentration of tolbutamide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with fleroxacin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rotigotine", "interaction_type": 75, "interaction_text": "The serum concentration of Rotigotine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "streptozocin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with streptozocin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Midostaurin", "interaction_type": 75, "interaction_text": "The serum concentration of Midostaurin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "ZINC OXIDE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with ZINC OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "loratadine", "interaction_type": 75, "interaction_text": "The serum concentration of loratadine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "primidone", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Asenapine", "interaction_type": 75, "interaction_text": "The serum concentration of Asenapine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "gemfibrozil", "interaction_type": 75, "interaction_text": "The serum concentration of gemfibrozil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "docetaxel", "interaction_type": 75, "interaction_text": "The serum concentration of docetaxel can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Darunavir", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "rosiglitazone", "interaction_type": 75, "interaction_text": "The serum concentration of rosiglitazone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "LESINURAD", "interaction_type": 75, "interaction_text": "The serum concentration of LESINURAD can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "CORTISONE ACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of CORTISONE ACETATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "pantoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of pantoprazole can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "riluzole", "interaction_type": 75, "interaction_text": "The serum concentration of riluzole can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "butorphanol", "interaction_type": 75, "interaction_text": "The serum concentration of butorphanol can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "cimetidine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "leflunomide", "interaction_type": 75, "interaction_text": "The serum concentration of leflunomide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "aminoglutethimide", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with aminoglutethimide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "indomethacin", "interaction_type": 75, "interaction_text": "The serum concentration of indomethacin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "montelukast", "interaction_type": 75, "interaction_text": "The serum concentration of montelukast can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "chlordiazepoxide", "interaction_type": 75, "interaction_text": "The serum concentration of chlordiazepoxide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Palonosetron", "interaction_type": 75, "interaction_text": "The serum concentration of Palonosetron can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "histamine", "interaction_type": 75, "interaction_text": "The serum concentration of histamine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "mirtazapine", "interaction_type": 75, "interaction_text": "The serum concentration of mirtazapine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "Myostibin", "interaction_type": 75, "interaction_text": "The serum concentration of Myostibin can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Grazoprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Grazoprevir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Elbasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Elbasvir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "thiamylal", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "equilin", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with equilin.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "topiramate", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "piperacillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "equilin", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with equilin.", "severity": 2}
{"drug1": "diflorasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with diflorasone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Bazedoxifene", "interaction_type": 75, "interaction_text": "The serum concentration of Bazedoxifene can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "felbamate", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "progesterone", "interaction_type": 75, "interaction_text": "The serum concentration of progesterone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "spiramycin", "interaction_type": 75, "interaction_text": "The serum concentration of spiramycin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "SERTINDOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SERTINDOLE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "orlistat", "drug2": "fludiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of fludiazepam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Deferasirox", "interaction_type": 75, "interaction_text": "The serum concentration of Deferasirox can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "thalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of thalidomide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Ecabet", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "ampicillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "ramipril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Tiotropium", "interaction_type": 75, "interaction_text": "The serum concentration of Tiotropium can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "metformin", "drug2": "Trospium", "interaction_type": 75, "interaction_text": "The serum concentration of Trospium can be decreased when it is combined with metformin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "azelastine", "interaction_type": 75, "interaction_text": "The serum concentration of azelastine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Telithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of Telithromycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "penicillin g", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "erythromycin", "interaction_type": 75, "interaction_text": "The serum concentration of erythromycin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "efavirenz", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "oxymorphone", "interaction_type": 75, "interaction_text": "The serum concentration of oxymorphone can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Almotriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Almotriptan can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "trimethoprim", "interaction_type": 75, "interaction_text": "The serum concentration of trimethoprim can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "orlistat", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Asunaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Asunaprevir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clofazimine", "interaction_type": 75, "interaction_text": "The serum concentration of clofazimine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "probenecid", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with probenecid.", "severity": 2}
{"drug1": "Bosentan", "drug2": "oxazepam", "interaction_type": 75, "interaction_text": "The serum concentration of oxazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "donepezil", "interaction_type": 75, "interaction_text": "The serum concentration of donepezil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "AMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of AMPHETAMINE can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cisplatin", "interaction_type": 75, "interaction_text": "The serum concentration of cisplatin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "temozolomide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with temozolomide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "primidone", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with paroxetine.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Isavuconazonium", "interaction_type": 75, "interaction_text": "The serum concentration of Isavuconazonium can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "formestane", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with formestane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "enalapril", "interaction_type": 75, "interaction_text": "The serum concentration of enalapril can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Tiotropium", "interaction_type": 75, "interaction_text": "The serum concentration of Tiotropium can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "LISURIDE", "interaction_type": 75, "interaction_text": "The serum concentration of LISURIDE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "primidone", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "domperidone", "interaction_type": 75, "interaction_text": "The serum concentration of domperidone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "pergolide", "interaction_type": 75, "interaction_text": "The serum concentration of pergolide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ifosfamide", "interaction_type": 75, "interaction_text": "The serum concentration of ifosfamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "naloxone", "interaction_type": 75, "interaction_text": "The serum concentration of naloxone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Vismodegib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "niclosamide", "interaction_type": 75, "interaction_text": "The serum concentration of niclosamide can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "docetaxel", "interaction_type": 75, "interaction_text": "The serum concentration of docetaxel can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with metoclopramide.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "hydroxyamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of hydroxyamphetamine can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "mitotane", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Copanlisib", "interaction_type": 75, "interaction_text": "The serum concentration of Copanlisib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with halcinonide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "bezafibrate", "interaction_type": 75, "interaction_text": "The serum concentration of bezafibrate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Yohimbine", "interaction_type": 75, "interaction_text": "The serum concentration of Yohimbine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "colchicine", "interaction_type": 75, "interaction_text": "The serum concentration of colchicine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ticlopidine", "interaction_type": 75, "interaction_text": "The serum concentration of ticlopidine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of tetracycline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dofetilide", "interaction_type": 75, "interaction_text": "The serum concentration of Dofetilide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "isoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of isoflurane can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "epinastine", "interaction_type": 75, "interaction_text": "The serum concentration of epinastine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Hydrocortamate", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Hydrocortamate.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "indinavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Aluminium", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "streptozocin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with streptozocin.", "severity": 2}
{"drug1": "halcinonide", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with halcinonide.", "severity": 2}
{"drug1": "primidone", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "mitotane", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "primidone", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Ertapenem", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Ertapenem.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with dextroamphetamine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "paromomycin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with paromomycin.", "severity": 2}
{"drug1": "primidone", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "benazepril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with simvastatin.", "severity": 2}
{"drug1": "primidone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "prednisone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with prednisone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "midazolam", "interaction_type": 75, "interaction_text": "The serum concentration of midazolam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "SUFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of SUFENTANIL can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "TAMSULOSIN", "interaction_type": 75, "interaction_text": "The serum concentration of TAMSULOSIN can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Eplerenone", "interaction_type": 75, "interaction_text": "The serum concentration of Eplerenone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "amprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of amprenavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with NORGESTIMATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "niclosamide", "interaction_type": 75, "interaction_text": "The serum concentration of niclosamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cephalexin", "interaction_type": 75, "interaction_text": "The serum concentration of cephalexin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Venetoclax", "interaction_type": 75, "interaction_text": "The serum concentration of Venetoclax can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "domperidone", "interaction_type": 75, "interaction_text": "The serum concentration of domperidone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "bicalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of bicalutamide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dutasteride", "interaction_type": 75, "interaction_text": "The serum concentration of Dutasteride can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Remikiren", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dicumarol", "interaction_type": 75, "interaction_text": "The serum concentration of dicumarol can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "doxepin", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rifampicin", "interaction_type": 75, "interaction_text": "The serum concentration of Rifampicin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "thiotepa", "interaction_type": 75, "interaction_text": "The serum concentration of thiotepa can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "chlordiazepoxide", "interaction_type": 75, "interaction_text": "The serum concentration of chlordiazepoxide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "montelukast", "interaction_type": 75, "interaction_text": "The serum concentration of montelukast can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with NORGESTIMATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cyclobenzaprine", "interaction_type": 75, "interaction_text": "The serum concentration of cyclobenzaprine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "prochlorperazine", "interaction_type": 75, "interaction_text": "The serum concentration of prochlorperazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "famotidine", "interaction_type": 75, "interaction_text": "The serum concentration of famotidine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nevirapine", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "cilazapril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Levocetirizine", "interaction_type": 75, "interaction_text": "The serum concentration of Levocetirizine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Spirapril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Bexarotene", "interaction_type": 75, "interaction_text": "The serum concentration of Bexarotene can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "argatroban", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lomitapide", "interaction_type": 75, "interaction_text": "The serum concentration of Lomitapide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "DIHYDROCODEINE", "interaction_type": 75, "interaction_text": "The serum concentration of DIHYDROCODEINE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "dyphylline", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clotiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clotiazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Vismodegib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "oxacillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "theobromine", "interaction_type": 75, "interaction_text": "The serum concentration of theobromine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "tiagabine", "interaction_type": 75, "interaction_text": "The serum concentration of tiagabine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "loratadine", "interaction_type": 75, "interaction_text": "The serum concentration of loratadine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "progesterone", "interaction_type": 75, "interaction_text": "The serum concentration of progesterone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "PRIMAQUINE", "interaction_type": 75, "interaction_text": "The serum concentration of PRIMAQUINE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "TASOSARTAN", "interaction_type": 75, "interaction_text": "The serum concentration of TASOSARTAN can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "pilocarpine", "interaction_type": 75, "interaction_text": "The serum concentration of pilocarpine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "felbamate", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "liothyronine", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with liothyronine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ERGOTAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of ERGOTAMINE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "flurazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flurazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "thiopental", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Almasilate", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROXYPROGESTERONE CAPROATE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "penicillin g", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "omeprazole", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "mitoxantrone", "interaction_type": 75, "interaction_text": "The serum concentration of mitoxantrone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Potassium alum", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Potassium alum.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Almasilate", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "Grazoprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Grazoprevir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "disulfiram", "interaction_type": 75, "interaction_text": "The serum concentration of disulfiram can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "midazolam", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with midazolam.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Voxilaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Voxilaprevir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Melatonin", "interaction_type": 75, "interaction_text": "The serum concentration of Melatonin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Isoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Isoconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with sumatriptan.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "efavirenz", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "DEZOCINE", "interaction_type": 75, "interaction_text": "The serum concentration of DEZOCINE can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Repaglinide", "interaction_type": 75, "interaction_text": "The serum concentration of Repaglinide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "tinidazole", "interaction_type": 75, "interaction_text": "The serum concentration of tinidazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Paricalcitol", "interaction_type": 75, "interaction_text": "The serum concentration of Paricalcitol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Enasidenib", "interaction_type": 75, "interaction_text": "The serum concentration of Enasidenib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "thiamine", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with thiamine.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "rabeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of rabeprazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Spectinomycin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "pyrazinamide", "interaction_type": 75, "interaction_text": "The serum concentration of pyrazinamide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "orlistat", "drug2": "Mephobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Mephobarbital can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "olanzapine", "interaction_type": 75, "interaction_text": "The serum concentration of olanzapine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "codeine", "interaction_type": 75, "interaction_text": "The serum concentration of codeine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dorzolamide", "interaction_type": 75, "interaction_text": "The serum concentration of dorzolamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Vardenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Vardenafil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "mitotane", "drug2": "pyrazinamide", "interaction_type": 75, "interaction_text": "The serum concentration of pyrazinamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ipratropium", "interaction_type": 75, "interaction_text": "The serum concentration of ipratropium can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "gliclazide", "interaction_type": 75, "interaction_text": "The serum concentration of gliclazide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "rabeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of rabeprazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ciprofloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of ciprofloxacin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "folinic acid", "drug2": "primidone", "interaction_type": 75, "interaction_text": "The serum concentration of primidone can be decreased when it is combined with folinic acid.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "caffeine", "interaction_type": 75, "interaction_text": "The serum concentration of caffeine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "eperisone", "interaction_type": 75, "interaction_text": "The serum concentration of eperisone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "azelastine", "interaction_type": 75, "interaction_text": "The serum concentration of azelastine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "SERTINDOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SERTINDOLE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "spiramycin", "interaction_type": 75, "interaction_text": "The serum concentration of spiramycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "enalapril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "enalapril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "suprofen", "interaction_type": 75, "interaction_text": "The serum concentration of suprofen can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "chlorphenesin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with chlorphenesin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "progesterone", "interaction_type": 75, "interaction_text": "The serum concentration of progesterone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "trimetrexate", "interaction_type": 75, "interaction_text": "The serum concentration of trimetrexate can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "reserpine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Sertaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Sertaconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "amphotericin b", "interaction_type": 75, "interaction_text": "The serum concentration of amphotericin b can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "osimertinib", "drug2": "thiabendazole", "interaction_type": 75, "interaction_text": "The serum concentration of thiabendazole can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "calcitriol", "interaction_type": 75, "interaction_text": "The serum concentration of calcitriol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "doxazosin", "interaction_type": 75, "interaction_text": "The serum concentration of doxazosin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Sitagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Sitagliptin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "progesterone", "interaction_type": 75, "interaction_text": "The serum concentration of progesterone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "modafinil", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "ethanol", "drug2": "dicumarol", "interaction_type": 75, "interaction_text": "The serum concentration of dicumarol can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "benazepril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "TASOSARTAN", "interaction_type": 75, "interaction_text": "The serum concentration of TASOSARTAN can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "thiabendazole", "interaction_type": 75, "interaction_text": "The serum concentration of thiabendazole can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "phenindione", "interaction_type": 75, "interaction_text": "The serum concentration of phenindione can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "captopril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "folic acid", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with folic acid.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "roxithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of roxithromycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "malathion", "interaction_type": 75, "interaction_text": "The serum concentration of malathion can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with oxiconazole.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Darunavir", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 75, "interaction_text": "The serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Melatonin", "interaction_type": 75, "interaction_text": "The serum concentration of Melatonin can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vilanterol", "interaction_type": 75, "interaction_text": "The serum concentration of Vilanterol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Imidafenacin", "interaction_type": 75, "interaction_text": "The serum concentration of Imidafenacin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "cyclobenzaprine", "interaction_type": 75, "interaction_text": "The serum concentration of cyclobenzaprine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "mesalamine", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with mesalamine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "methenamine", "drug2": "MEPHENTERMINE", "interaction_type": 75, "interaction_text": "The serum concentration of MEPHENTERMINE can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "benazepril", "interaction_type": 75, "interaction_text": "The serum concentration of benazepril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "OLODATEROL", "interaction_type": 75, "interaction_text": "The serum concentration of OLODATEROL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vilanterol", "interaction_type": 75, "interaction_text": "The serum concentration of Vilanterol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Permethrin", "interaction_type": 75, "interaction_text": "The serum concentration of Permethrin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ospemifene", "interaction_type": 75, "interaction_text": "The serum concentration of Ospemifene can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "LESINURAD", "interaction_type": 75, "interaction_text": "The serum concentration of LESINURAD can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Neratinib", "interaction_type": 75, "interaction_text": "The serum concentration of Neratinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "orlistat", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Avanafil", "interaction_type": 75, "interaction_text": "The serum concentration of Avanafil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Olopatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Olopatadine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Sevelamer", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Sevelamer.", "severity": 2}
{"drug1": "mitotane", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "azithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of azithromycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "enalapril", "interaction_type": 75, "interaction_text": "The serum concentration of enalapril can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "LISURIDE", "interaction_type": 75, "interaction_text": "The serum concentration of LISURIDE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "trientine", "interaction_type": 75, "interaction_text": "The serum concentration of trientine can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lomitapide", "interaction_type": 75, "interaction_text": "The serum concentration of Lomitapide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Vismodegib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Levomefolic acid.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "ritonavir", "drug2": "olanzapine", "interaction_type": 75, "interaction_text": "The serum concentration of olanzapine can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Olopatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Olopatadine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "resveratrol", "interaction_type": 75, "interaction_text": "The serum concentration of resveratrol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "thiopental", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "felbamate", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "phenoxybenzamine", "interaction_type": 75, "interaction_text": "The serum concentration of phenoxybenzamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with methotrexate.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "methicillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "pentazocine", "interaction_type": 75, "interaction_text": "The serum concentration of pentazocine can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "diltiazem", "interaction_type": 75, "interaction_text": "The serum concentration of diltiazem can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "colchicine", "interaction_type": 75, "interaction_text": "The serum concentration of colchicine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Yohimbine", "interaction_type": 75, "interaction_text": "The serum concentration of Yohimbine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "bezafibrate", "interaction_type": 75, "interaction_text": "The serum concentration of bezafibrate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Spirapril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "testosterone", "interaction_type": 75, "interaction_text": "The serum concentration of testosterone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nicardipine", "interaction_type": 75, "interaction_text": "The serum concentration of nicardipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ergocalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of ergocalciferol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "triamcinolone", "interaction_type": 75, "interaction_text": "The serum concentration of triamcinolone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clorazepate", "interaction_type": 75, "interaction_text": "The serum concentration of clorazepate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "osimertinib", "drug2": "triamterene", "interaction_type": 75, "interaction_text": "The serum concentration of triamterene can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tiagabine", "interaction_type": 75, "interaction_text": "The serum concentration of tiagabine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cocaine", "interaction_type": 75, "interaction_text": "The serum concentration of cocaine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ambrisentan", "interaction_type": 75, "interaction_text": "The serum concentration of Ambrisentan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "cyclobenzaprine", "interaction_type": 75, "interaction_text": "The serum concentration of cyclobenzaprine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "phenoxybenzamine", "interaction_type": 75, "interaction_text": "The serum concentration of phenoxybenzamine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "orlistat", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "orlistat", "drug2": "thiopental", "interaction_type": 75, "interaction_text": "The serum concentration of thiopental can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "colchicine", "drug2": "vitamin B12", "interaction_type": 75, "interaction_text": "The serum concentration of vitamin B12 can be decreased when it is combined with colchicine.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "sulfasalazine", "drug2": "folic acid", "interaction_type": 75, "interaction_text": "The serum concentration of folic acid can be decreased when it is combined with sulfasalazine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Bendamustine", "interaction_type": 75, "interaction_text": "The serum concentration of Bendamustine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "donepezil", "interaction_type": 75, "interaction_text": "The serum concentration of donepezil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "oxazepam", "interaction_type": 75, "interaction_text": "The serum concentration of oxazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clofazimine", "interaction_type": 75, "interaction_text": "The serum concentration of clofazimine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "paromomycin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with paromomycin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "mitotane", "drug2": "clindamycin", "interaction_type": 75, "interaction_text": "The serum concentration of clindamycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "oxymorphone", "interaction_type": 75, "interaction_text": "The serum concentration of oxymorphone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "mitotane", "drug2": "zopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of zopiclone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Levomilnacipran", "interaction_type": 75, "interaction_text": "The serum concentration of Levomilnacipran can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "pilocarpine", "interaction_type": 75, "interaction_text": "The serum concentration of pilocarpine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "PRIMAQUINE", "interaction_type": 75, "interaction_text": "The serum concentration of PRIMAQUINE can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "orlistat", "drug2": "vigabatrin", "interaction_type": 75, "interaction_text": "The serum concentration of vigabatrin can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "furosemide", "interaction_type": 75, "interaction_text": "The serum concentration of furosemide can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "oxymorphone", "interaction_type": 75, "interaction_text": "The serum concentration of oxymorphone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Benidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Benidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Amrinone", "interaction_type": 75, "interaction_text": "The serum concentration of Amrinone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "pyridostigmine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with pyridostigmine.", "severity": 2}
{"drug1": "mitotane", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ergocalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of ergocalciferol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "celecoxib", "interaction_type": 75, "interaction_text": "The serum concentration of celecoxib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "raloxifene", "interaction_type": 75, "interaction_text": "The serum concentration of raloxifene can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "nitrendipine", "interaction_type": 75, "interaction_text": "The serum concentration of nitrendipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "chlorzoxazone", "interaction_type": 75, "interaction_text": "The serum concentration of chlorzoxazone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "sulfadiazine", "interaction_type": 75, "interaction_text": "The serum concentration of sulfadiazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "indapamide", "interaction_type": 75, "interaction_text": "The serum concentration of indapamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "captopril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ambrisentan", "interaction_type": 75, "interaction_text": "The serum concentration of Ambrisentan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "chloroquine", "drug2": "suramin", "interaction_type": 75, "interaction_text": "The serum concentration of suramin can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "codeine", "interaction_type": 75, "interaction_text": "The serum concentration of codeine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Salmeterol", "interaction_type": 75, "interaction_text": "The serum concentration of Salmeterol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cabergoline", "interaction_type": 75, "interaction_text": "The serum concentration of cabergoline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ziprasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ziprasidone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "betaxolol", "interaction_type": 75, "interaction_text": "The serum concentration of betaxolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Valbenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Valbenazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Nebivolol", "interaction_type": 75, "interaction_text": "The serum concentration of Nebivolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "tolperisone", "interaction_type": 75, "interaction_text": "The serum concentration of tolperisone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "streptomycin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with streptomycin.", "severity": 2}
{"drug1": "primidone", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "rizatriptan", "interaction_type": 75, "interaction_text": "The serum concentration of rizatriptan can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "oxymorphone", "interaction_type": 75, "interaction_text": "The serum concentration of oxymorphone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clindamycin", "interaction_type": 75, "interaction_text": "The serum concentration of clindamycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "enalapril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of zopiclone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with flurandrenolide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "penbutolol", "interaction_type": 75, "interaction_text": "The serum concentration of penbutolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Amrinone", "interaction_type": 75, "interaction_text": "The serum concentration of Amrinone can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nefazodone", "interaction_type": 75, "interaction_text": "The serum concentration of nefazodone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ambrisentan", "interaction_type": 75, "interaction_text": "The serum concentration of Ambrisentan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with Gemifloxacin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "bromocriptine", "interaction_type": 75, "interaction_text": "The serum concentration of bromocriptine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Valbenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Valbenazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "Deutetrabenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Deutetrabenazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Alogliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Alogliptin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "promethazine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "diethylcarbamazine", "interaction_type": 75, "interaction_text": "The serum concentration of diethylcarbamazine can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "flurbiprofen", "interaction_type": 75, "interaction_text": "The serum concentration of flurbiprofen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "nalbuphine", "interaction_type": 75, "interaction_text": "The serum concentration of nalbuphine can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "dextromethorphan", "interaction_type": 75, "interaction_text": "The serum concentration of dextromethorphan can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "osimertinib", "drug2": "thalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of thalidomide can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Bosentan", "interaction_type": 75, "interaction_text": "The serum concentration of Bosentan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "mitotane", "drug2": "methoxsalen", "interaction_type": 75, "interaction_text": "The serum concentration of methoxsalen can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Ethamolin", "interaction_type": 75, "interaction_text": "The serum concentration of Ethamolin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dofetilide", "interaction_type": 75, "interaction_text": "The serum concentration of Dofetilide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ambroxol", "interaction_type": 75, "interaction_text": "The serum concentration of ambroxol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with cholic acid.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "azlocillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "modafinil", "interaction_type": 75, "interaction_text": "The serum concentration of modafinil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Vilanterol", "interaction_type": 75, "interaction_text": "The serum concentration of Vilanterol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with Rufinamide.", "severity": 2}
{"drug1": "indinavir", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with alclometasone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "benazepril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Liotrix", "interaction_type": 75, "interaction_text": "The serum concentration of Liotrix can be decreased when it is combined with ciprofloxacin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Mometasone.", "severity": 2}
{"drug1": "primidone", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "trimipramine", "interaction_type": 75, "interaction_text": "The serum concentration of trimipramine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "IMIQUIMOD", "interaction_type": 75, "interaction_text": "The serum concentration of IMIQUIMOD can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ambrisentan", "interaction_type": 75, "interaction_text": "The serum concentration of Ambrisentan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Permethrin", "interaction_type": 75, "interaction_text": "The serum concentration of Permethrin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ospemifene", "interaction_type": 75, "interaction_text": "The serum concentration of Ospemifene can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "primidone", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "mitotane", "drug2": "Permethrin", "interaction_type": 75, "interaction_text": "The serum concentration of Permethrin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "primidone", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "5-Fluorouracil", "interaction_type": 75, "interaction_text": "The serum concentration of 5-Fluorouracil can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "primidone", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with propoxyphene.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "DIHYDROCODEINE", "interaction_type": 75, "interaction_text": "The serum concentration of DIHYDROCODEINE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "VITAMIN E", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with VITAMIN E.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clotiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clotiazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "benazepril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "Aluminium", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "modafinil", "interaction_type": 75, "interaction_text": "The serum concentration of modafinil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Almasilate", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 75, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ambrisentan", "interaction_type": 75, "interaction_text": "The serum concentration of Ambrisentan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "IMIQUIMOD", "interaction_type": 75, "interaction_text": "The serum concentration of IMIQUIMOD can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "montelukast", "interaction_type": 75, "interaction_text": "The serum concentration of montelukast can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "doxepin", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "PYRANTEL", "interaction_type": 75, "interaction_text": "The serum concentration of PYRANTEL can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "roxithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of roxithromycin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Eslicarbazepine acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Eslicarbazepine acetate can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "dorzolamide", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with dorzolamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cisapride", "interaction_type": 75, "interaction_text": "The serum concentration of cisapride can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "AZATADINE", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with AZATADINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "mitotane", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "METHAMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of METHAMPHETAMINE can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "paramethasone", "interaction_type": 75, "interaction_text": "The serum concentration of paramethasone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "CORTISONE ACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of CORTISONE ACETATE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "benzyl alcohol", "interaction_type": 75, "interaction_text": "The serum concentration of benzyl alcohol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with mifepristone.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cephalexin", "interaction_type": 75, "interaction_text": "The serum concentration of cephalexin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Asenapine", "interaction_type": 75, "interaction_text": "The serum concentration of Asenapine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nafcillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Gliquidone", "interaction_type": 75, "interaction_text": "The serum concentration of Gliquidone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ambroxol", "interaction_type": 75, "interaction_text": "The serum concentration of ambroxol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "orphenadrine", "interaction_type": 75, "interaction_text": "The serum concentration of orphenadrine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "lisinopril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with thalidomide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Asenapine", "interaction_type": 75, "interaction_text": "The serum concentration of Asenapine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dorzolamide", "interaction_type": 75, "interaction_text": "The serum concentration of dorzolamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "tobramycin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with tobramycin.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Amfepramone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Vardenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Vardenafil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Dipotassium hydrogen phosphate", "interaction_type": 75, "interaction_text": "The serum concentration of Dipotassium hydrogen phosphate can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "primidone", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Artemether", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "amprenavir", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dasabuvir", "interaction_type": 75, "interaction_text": "The serum concentration of Dasabuvir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "caffeine", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with caffeine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Caspofungin", "interaction_type": 75, "interaction_text": "The serum concentration of Caspofungin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with Levoleucovorin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "digoxin", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with digoxin.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "barnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of barnidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with mifepristone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "prazepam", "interaction_type": 75, "interaction_text": "The serum concentration of prazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "EDOXABAN", "interaction_type": 75, "interaction_text": "The serum concentration of EDOXABAN can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Liotrix", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Liotrix.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "raloxifene", "interaction_type": 75, "interaction_text": "The serum concentration of raloxifene can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "celecoxib", "interaction_type": 75, "interaction_text": "The serum concentration of celecoxib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "mefloquine", "interaction_type": 75, "interaction_text": "The serum concentration of mefloquine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "sulfadiazine", "interaction_type": 75, "interaction_text": "The serum concentration of sulfadiazine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Palonosetron", "interaction_type": 75, "interaction_text": "The serum concentration of Palonosetron can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "meprobamate", "interaction_type": 75, "interaction_text": "The serum concentration of meprobamate can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "mirtazapine", "interaction_type": 75, "interaction_text": "The serum concentration of mirtazapine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Velpatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Velpatasvir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "doxepin", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "quinapril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "disulfiram", "interaction_type": 75, "interaction_text": "The serum concentration of disulfiram can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ropinirole", "interaction_type": 75, "interaction_text": "The serum concentration of ropinirole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "mitotane", "drug2": "mirtazapine", "interaction_type": 75, "interaction_text": "The serum concentration of mirtazapine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Palonosetron", "interaction_type": 75, "interaction_text": "The serum concentration of Palonosetron can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Lomitapide", "interaction_type": 75, "interaction_text": "The serum concentration of Lomitapide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Avanafil", "interaction_type": 75, "interaction_text": "The serum concentration of Avanafil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Levobupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Levobupivacaine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "ceritinib", "interaction_type": 75, "interaction_text": "The serum concentration of ceritinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Mirabegron", "interaction_type": 75, "interaction_text": "The serum concentration of Mirabegron can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "amikacin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with amikacin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Artemether", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Isavuconazonium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "topiramate", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Tiotropium", "interaction_type": 75, "interaction_text": "The serum concentration of Tiotropium can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "chlorzoxazone", "interaction_type": 75, "interaction_text": "The serum concentration of chlorzoxazone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Rotigotine", "interaction_type": 75, "interaction_text": "The serum concentration of Rotigotine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "dyphylline", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with dyphylline.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mefloquine", "interaction_type": 75, "interaction_text": "The serum concentration of mefloquine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "rabeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of rabeprazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "bicalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of bicalutamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dutasteride", "interaction_type": 75, "interaction_text": "The serum concentration of Dutasteride can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "captopril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dexlansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of dexlansoprazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mycophenolate mofetil", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolate mofetil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "osimertinib", "drug2": "anagrelide", "interaction_type": 75, "interaction_text": "The serum concentration of anagrelide can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "midazolam", "interaction_type": 75, "interaction_text": "The serum concentration of midazolam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "methoxsalen", "interaction_type": 75, "interaction_text": "The serum concentration of methoxsalen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Bosentan", "interaction_type": 75, "interaction_text": "The serum concentration of Bosentan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ketamine", "interaction_type": 75, "interaction_text": "The serum concentration of ketamine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Flubendazole", "interaction_type": 75, "interaction_text": "The serum concentration of Flubendazole can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with Pefloxacin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "fosinopril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Neratinib", "interaction_type": 75, "interaction_text": "The serum concentration of Neratinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "risperidone", "interaction_type": 75, "interaction_text": "The serum concentration of risperidone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nateglinide", "interaction_type": 75, "interaction_text": "The serum concentration of nateglinide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "fosinopril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "PRIMAQUINE", "interaction_type": 75, "interaction_text": "The serum concentration of PRIMAQUINE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nystatin", "interaction_type": 75, "interaction_text": "The serum concentration of nystatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Atomoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Atomoxetine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "venlafaxine", "interaction_type": 75, "interaction_text": "The serum concentration of venlafaxine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mesalamine", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with mesalamine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clotiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clotiazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "DIHYDROCODEINE", "interaction_type": 75, "interaction_text": "The serum concentration of DIHYDROCODEINE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "quinapril", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ketamine", "interaction_type": 75, "interaction_text": "The serum concentration of ketamine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "penicillin v", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "mitotane", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "vinblastine", "interaction_type": 75, "interaction_text": "The serum concentration of vinblastine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nafcillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "chlordiazepoxide", "interaction_type": 75, "interaction_text": "The serum concentration of chlordiazepoxide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "montelukast", "interaction_type": 75, "interaction_text": "The serum concentration of montelukast can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "promethazine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "thiotepa", "interaction_type": 75, "interaction_text": "The serum concentration of thiotepa can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenytoin", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "azlocillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "histamine", "interaction_type": 75, "interaction_text": "The serum concentration of histamine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Avanafil", "interaction_type": 75, "interaction_text": "The serum concentration of Avanafil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "didanosine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with didanosine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "piperazine", "interaction_type": 75, "interaction_text": "The serum concentration of piperazine can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "liothyronine", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with liothyronine.", "severity": 2}
{"drug1": "primidone", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "thiamylal", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Prasugrel", "interaction_type": 75, "interaction_text": "The serum concentration of Prasugrel can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "levodopa", "interaction_type": 75, "interaction_text": "The serum concentration of levodopa can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Midostaurin", "interaction_type": 75, "interaction_text": "The serum concentration of Midostaurin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "SELENIUM", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with SELENIUM.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Metipranolol", "interaction_type": 75, "interaction_text": "The serum concentration of Metipranolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "glyburide", "interaction_type": 75, "interaction_text": "The serum concentration of glyburide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Miltefosine", "interaction_type": 75, "interaction_text": "The serum concentration of Miltefosine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "streptomycin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with streptomycin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Trometamol", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "mitotane", "drug2": "tolterodine", "interaction_type": 75, "interaction_text": "The serum concentration of tolterodine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "famotidine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "oxaliplatin", "interaction_type": 75, "interaction_text": "The serum concentration of oxaliplatin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Aluminium", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Vismodegib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ampicillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "folic acid", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with folic acid.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lomitapide", "interaction_type": 75, "interaction_text": "The serum concentration of Lomitapide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Imidafenacin", "interaction_type": 75, "interaction_text": "The serum concentration of Imidafenacin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "trimipramine", "interaction_type": 75, "interaction_text": "The serum concentration of trimipramine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "risperidone", "interaction_type": 75, "interaction_text": "The serum concentration of risperidone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nateglinide", "interaction_type": 75, "interaction_text": "The serum concentration of nateglinide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Perospirone", "interaction_type": 75, "interaction_text": "The serum concentration of Perospirone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "prazosin", "interaction_type": 75, "interaction_text": "The serum concentration of prazosin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "trandolapril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "phenytoin", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Arbekacin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with Arbekacin.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "efavirenz", "drug2": "diltiazem", "interaction_type": 75, "interaction_text": "The serum concentration of diltiazem can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Almotriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Almotriptan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "oxacillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "glyburide", "interaction_type": 75, "interaction_text": "The serum concentration of glyburide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sulfamethoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfamethoxazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "dicumarol", "interaction_type": 75, "interaction_text": "The serum concentration of dicumarol can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "VERAPAMIL", "interaction_type": 75, "interaction_text": "The serum concentration of VERAPAMIL can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "bepridil", "interaction_type": 75, "interaction_text": "The serum concentration of bepridil can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "primidone", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "estriol", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with estriol.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zalcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of zalcitabine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Fulvestrant", "interaction_type": 75, "interaction_text": "The serum concentration of Fulvestrant can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "aspirin", "interaction_type": 75, "interaction_text": "The serum concentration of aspirin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "ramipril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nimesulide", "interaction_type": 75, "interaction_text": "The serum concentration of nimesulide can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "osimertinib", "drug2": "tizanidine", "interaction_type": 75, "interaction_text": "The serum concentration of tizanidine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "trandolapril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ADINAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of ADINAZOLAM can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Liotrix", "interaction_type": 75, "interaction_text": "The serum concentration of Liotrix can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "MAGNESIUM SULFATE", "interaction_type": 75, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Avanafil", "interaction_type": 75, "interaction_text": "The serum concentration of Avanafil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Darunavir", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "osimertinib", "drug2": "oxaliplatin", "interaction_type": 75, "interaction_text": "The serum concentration of oxaliplatin can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "mesalamine", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with mesalamine.", "severity": 2}
{"drug1": "minocycline", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with minocycline.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE DINITRATE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "granisetron", "interaction_type": 75, "interaction_text": "The serum concentration of granisetron can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Cilastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Cilastatin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "primidone", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "mitotane", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "etizolam", "interaction_type": 75, "interaction_text": "The serum concentration of etizolam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Artemether", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "nafcillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "vindesine", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with vindesine.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "ramipril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "lisinopril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "LEVOBUNOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOBUNOLOL can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "menadione", "interaction_type": 75, "interaction_text": "The serum concentration of menadione can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "fluvoxamine", "interaction_type": 75, "interaction_text": "The serum concentration of fluvoxamine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Trovafloxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Trovafloxacin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "famotidine", "interaction_type": 75, "interaction_text": "The serum concentration of famotidine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with venlafaxine.", "severity": 2}
{"drug1": "penicillin v", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "mitotane", "drug2": "midazolam", "interaction_type": 75, "interaction_text": "The serum concentration of midazolam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "mitotane", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "mitotane", "drug2": "mycophenolate mofetil", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolate mofetil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "progesterone", "interaction_type": 75, "interaction_text": "The serum concentration of progesterone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "orlistat", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "levodopa", "interaction_type": 75, "interaction_text": "The serum concentration of levodopa can be decreased when it is combined with Glycopyrronium.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "sulfadiazine", "interaction_type": 75, "interaction_text": "The serum concentration of sulfadiazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "mefloquine", "interaction_type": 75, "interaction_text": "The serum concentration of mefloquine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "chlorzoxazone", "interaction_type": 75, "interaction_text": "The serum concentration of chlorzoxazone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "caffeine", "interaction_type": 75, "interaction_text": "The serum concentration of caffeine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "azithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of azithromycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dofetilide", "interaction_type": 75, "interaction_text": "The serum concentration of Dofetilide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ticlopidine", "interaction_type": 75, "interaction_text": "The serum concentration of ticlopidine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dorzolamide", "interaction_type": 75, "interaction_text": "The serum concentration of dorzolamide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "methicillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Almasilate", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nadolol", "interaction_type": 75, "interaction_text": "The serum concentration of nadolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Clobetasone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with thalidomide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Darunavir", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "penicillin v", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mirtazapine", "interaction_type": 75, "interaction_text": "The serum concentration of mirtazapine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "penicillin v", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "bezafibrate", "interaction_type": 75, "interaction_text": "The serum concentration of bezafibrate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Yohimbine", "interaction_type": 75, "interaction_text": "The serum concentration of Yohimbine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "sibutramine", "interaction_type": 75, "interaction_text": "The serum concentration of sibutramine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "SERTINDOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SERTINDOLE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "spiramycin", "interaction_type": 75, "interaction_text": "The serum concentration of spiramycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "midazolam", "interaction_type": 75, "interaction_text": "The serum concentration of midazolam can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "azlocillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Asenapine", "interaction_type": 75, "interaction_text": "The serum concentration of Asenapine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "ambroxol", "interaction_type": 75, "interaction_text": "The serum concentration of ambroxol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ergocalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of ergocalciferol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cyclophosphamide", "interaction_type": 75, "interaction_text": "The serum concentration of cyclophosphamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Spirapril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Ecabet", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Bosentan", "drug2": "quazepam", "interaction_type": 75, "interaction_text": "The serum concentration of quazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "promethazine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "venlafaxine", "interaction_type": 75, "interaction_text": "The serum concentration of venlafaxine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "lidocaine", "interaction_type": 75, "interaction_text": "The serum concentration of lidocaine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Atomoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Atomoxetine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Pimecrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Pimecrolimus can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "PYRANTEL", "interaction_type": 75, "interaction_text": "The serum concentration of PYRANTEL can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "leflunomide", "interaction_type": 75, "interaction_text": "The serum concentration of leflunomide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with NORGESTIMATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "efavirenz", "drug2": "clarithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of clarithromycin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "isradipine", "interaction_type": 75, "interaction_text": "The serum concentration of isradipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dexlansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of dexlansoprazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "argatroban", "interaction_type": 75, "interaction_text": "The serum concentration of argatroban can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "bromocriptine", "interaction_type": 75, "interaction_text": "The serum concentration of bromocriptine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "dextromethorphan", "interaction_type": 75, "interaction_text": "The serum concentration of dextromethorphan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "enalapril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ketamine", "interaction_type": 75, "interaction_text": "The serum concentration of ketamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Deutetrabenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Deutetrabenazine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "SELENIUM", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with SELENIUM.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Valbenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Valbenazine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Propoxyphene napsylate", "interaction_type": 75, "interaction_text": "The serum concentration of Propoxyphene napsylate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vitamin D3", "interaction_type": 75, "interaction_text": "The serum concentration of Vitamin D3 can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "chloroquine", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "AMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of AMPHETAMINE can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "lisinopril", "interaction_type": 75, "interaction_text": "The serum concentration of lisinopril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Rimonabant", "interaction_type": 75, "interaction_text": "The serum concentration of Rimonabant can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Grazoprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Grazoprevir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Elbasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Elbasvir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "primidone", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Grazoprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Grazoprevir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Elbasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Elbasvir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ERGOTAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of ERGOTAMINE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "flurazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flurazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Aluminium", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "methenamine", "drug2": "Lisdexamfetamine", "interaction_type": 75, "interaction_text": "The serum concentration of Lisdexamfetamine can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "lomefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of lomefloxacin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "loratadine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with loratadine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "VERAPAMIL", "interaction_type": 75, "interaction_text": "The serum concentration of VERAPAMIL can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "SUFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of SUFENTANIL can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "TAMSULOSIN", "interaction_type": 75, "interaction_text": "The serum concentration of TAMSULOSIN can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "amprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of amprenavir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Eplerenone", "interaction_type": 75, "interaction_text": "The serum concentration of Eplerenone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "dapsone", "interaction_type": 75, "interaction_text": "The serum concentration of dapsone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flurbiprofen", "interaction_type": 75, "interaction_text": "The serum concentration of flurbiprofen can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "BISOPROLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BISOPROLOL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "isradipine", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with isradipine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with Levomefolic acid.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Pregabalin", "interaction_type": 75, "interaction_text": "The serum concentration of Pregabalin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "thiopental", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "trandolapril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "primidone", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "chlorpheniramine", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpheniramine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with nifedipine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "amitriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of amitriptyline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "netilmicin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with netilmicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "xylometazoline", "interaction_type": 75, "interaction_text": "The serum concentration of xylometazoline can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "mitotane", "drug2": "Repaglinide", "interaction_type": 75, "interaction_text": "The serum concentration of Repaglinide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Artemether", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "tinidazole", "interaction_type": 75, "interaction_text": "The serum concentration of tinidazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "propoxyphene", "interaction_type": 75, "interaction_text": "The serum concentration of propoxyphene can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "clofibrate", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with clofibrate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tolterodine", "interaction_type": 75, "interaction_text": "The serum concentration of tolterodine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "fenofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of fenofibrate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "alclometasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with alclometasone.", "severity": 2}
{"drug1": "Darunavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "orlistat", "drug2": "Ifenprodil", "interaction_type": 75, "interaction_text": "The serum concentration of Ifenprodil can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "tolbutamide", "interaction_type": 75, "interaction_text": "The serum concentration of tolbutamide can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "5-Fluorocytosine", "interaction_type": 75, "interaction_text": "The serum concentration of 5-Fluorocytosine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with fluocinonide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "butenafine", "interaction_type": 75, "interaction_text": "The serum concentration of butenafine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "mitotane", "drug2": "cytarabine", "interaction_type": 75, "interaction_text": "The serum concentration of cytarabine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with vinblastine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Elbasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Elbasvir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "felbamate", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "chlorpropamide", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpropamide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "diethylcarbamazine", "interaction_type": 75, "interaction_text": "The serum concentration of diethylcarbamazine can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Lumefantrine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "osimertinib", "drug2": "5-Fluorouracil", "interaction_type": 75, "interaction_text": "The serum concentration of 5-Fluorouracil can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "TROLEANDOMYCIN", "interaction_type": 75, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Ximelagatran", "interaction_type": 75, "interaction_text": "The serum concentration of Ximelagatran can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "primidone", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Asenapine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Asenapine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "nafcillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "amiodarone", "interaction_type": 75, "interaction_text": "The serum concentration of amiodarone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "chlorpheniramine", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpheniramine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "miconazole", "interaction_type": 75, "interaction_text": "The serum concentration of miconazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "podophyllotoxin", "interaction_type": 75, "interaction_text": "The serum concentration of podophyllotoxin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "orphenadrine", "interaction_type": 75, "interaction_text": "The serum concentration of orphenadrine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "amobarbital", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "amobarbital", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "amprenavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "efavirenz", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "tobramycin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with tobramycin.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "LUCANTHONE", "interaction_type": 75, "interaction_text": "The serum concentration of LUCANTHONE can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "labetalol", "interaction_type": 75, "interaction_text": "The serum concentration of labetalol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "methenamine", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "calcitriol", "interaction_type": 75, "interaction_text": "The serum concentration of calcitriol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nicardipine", "interaction_type": 75, "interaction_text": "The serum concentration of nicardipine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Bazedoxifene", "interaction_type": 75, "interaction_text": "The serum concentration of Bazedoxifene can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "zalcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of zalcitabine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "estrone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "guanabenz", "interaction_type": 75, "interaction_text": "The serum concentration of guanabenz can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "penicillin v", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "primidone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "trimethoprim", "interaction_type": 75, "interaction_text": "The serum concentration of trimethoprim can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "lansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of lansoprazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "erythromycin", "interaction_type": 75, "interaction_text": "The serum concentration of erythromycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "metrizamide", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with metrizamide.", "severity": 2}
{"drug1": "estriol", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with estriol.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "Amfepramone", "interaction_type": 75, "interaction_text": "The serum concentration of Amfepramone can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "trandolapril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "benazepril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "quinidine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with quinidine.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "thalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of thalidomide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Sevelamer", "drug2": "calcitriol", "interaction_type": 75, "interaction_text": "The serum concentration of calcitriol can be decreased when it is combined with Sevelamer.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tolfenamic acid", "interaction_type": 75, "interaction_text": "The serum concentration of tolfenamic acid can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Artemether", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with FLUOCORTOLONE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "midazolam", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with midazolam.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "codeine", "interaction_type": 75, "interaction_text": "The serum concentration of codeine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "netilmicin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with netilmicin.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "trandolapril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "ritonavir", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "primidone", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "promethazine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "Spirapril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nitrendipine", "interaction_type": 75, "interaction_text": "The serum concentration of nitrendipine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dextromethorphan", "interaction_type": 75, "interaction_text": "The serum concentration of dextromethorphan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Aliskiren", "interaction_type": 75, "interaction_text": "The serum concentration of Aliskiren can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "zolmitriptan", "interaction_type": 75, "interaction_text": "The serum concentration of zolmitriptan can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "indinavir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "doxepin", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "BISMUTH SUBSALICYLATE", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with BISMUTH SUBSALICYLATE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dehydroepiandrosterone", "interaction_type": 75, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "betaxolol", "interaction_type": 75, "interaction_text": "The serum concentration of betaxolol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dapsone", "interaction_type": 75, "interaction_text": "The serum concentration of dapsone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "methicillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "folic acid", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with folic acid.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Carfilzomib", "interaction_type": 75, "interaction_text": "The serum concentration of Carfilzomib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "osimertinib", "drug2": "rizatriptan", "interaction_type": 75, "interaction_text": "The serum concentration of rizatriptan can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Sitagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Sitagliptin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "mitotane", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "cyclophosphamide", "interaction_type": 75, "interaction_text": "The serum concentration of cyclophosphamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "bromocriptine", "interaction_type": 75, "interaction_text": "The serum concentration of bromocriptine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "prochlorperazine", "interaction_type": 75, "interaction_text": "The serum concentration of prochlorperazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "valsartan", "interaction_type": 75, "interaction_text": "The serum concentration of valsartan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "azlocillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "tobramycin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with tobramycin.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Aluminium", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Nintedanib", "interaction_type": 75, "interaction_text": "The serum concentration of Nintedanib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cyclobenzaprine", "interaction_type": 75, "interaction_text": "The serum concentration of cyclobenzaprine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "phenoxybenzamine", "interaction_type": 75, "interaction_text": "The serum concentration of phenoxybenzamine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "trazodone", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with trazodone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "oxacillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Darunavir", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "mitotane", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "piperacillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "orlistat", "drug2": "phenacemide", "interaction_type": 75, "interaction_text": "The serum concentration of phenacemide can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "nicardipine", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "trandolapril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clomiphene", "interaction_type": 75, "interaction_text": "The serum concentration of clomiphene can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with sparfloxacin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "netilmicin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with netilmicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "argatroban", "interaction_type": 75, "interaction_text": "The serum concentration of argatroban can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "isradipine", "interaction_type": 75, "interaction_text": "The serum concentration of isradipine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "quinapril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Voxilaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Voxilaprevir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "ranitidine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Pralatrexate", "drug2": "Sapropterin", "interaction_type": 75, "interaction_text": "The serum concentration of Sapropterin can be decreased when it is combined with Pralatrexate.", "severity": 2}
{"drug1": "modafinil", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "primidone", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "captopril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ibuprofen", "interaction_type": 75, "interaction_text": "The serum concentration of ibuprofen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nitrendipine", "interaction_type": 75, "interaction_text": "The serum concentration of nitrendipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nitrendipine", "interaction_type": 75, "interaction_text": "The serum concentration of nitrendipine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "anastrozole", "interaction_type": 75, "interaction_text": "The serum concentration of anastrozole can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "NAPROXEN", "interaction_type": 75, "interaction_text": "The serum concentration of NAPROXEN can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "thiopental", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "mitotane", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "benazepril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "lisinopril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "clozapine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with clozapine.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "thiabendazole", "interaction_type": 75, "interaction_text": "The serum concentration of thiabendazole can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Perospirone", "interaction_type": 75, "interaction_text": "The serum concentration of Perospirone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "argatroban", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "osimertinib", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ethanol", "interaction_type": 75, "interaction_text": "The serum concentration of ethanol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Olsalazine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "piperacillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "epinastine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Pioglitazone", "interaction_type": 75, "interaction_text": "The serum concentration of Pioglitazone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sulfinpyrazone", "interaction_type": 75, "interaction_text": "The serum concentration of sulfinpyrazone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "amiodarone", "interaction_type": 75, "interaction_text": "The serum concentration of amiodarone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "enalapril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "miconazole", "interaction_type": 75, "interaction_text": "The serum concentration of miconazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "metyrapone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with metyrapone.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Rufinamide.", "severity": 2}
{"drug1": "captopril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Artemether", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "AZATADINE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with AZATADINE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "cisapride", "interaction_type": 75, "interaction_text": "The serum concentration of cisapride can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nafcillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nafcillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "vincristine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with vincristine.", "severity": 2}
{"drug1": "mitotane", "drug2": "propoxyphene", "interaction_type": 75, "interaction_text": "The serum concentration of propoxyphene can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "mitotane", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "famciclovir", "interaction_type": 75, "interaction_text": "The serum concentration of famciclovir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "thiotepa", "interaction_type": 75, "interaction_text": "The serum concentration of thiotepa can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ampicillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "probenecid", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with probenecid.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "propofol", "interaction_type": 75, "interaction_text": "The serum concentration of propofol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "tobramycin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with tobramycin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "progesterone", "interaction_type": 75, "interaction_text": "The serum concentration of progesterone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "streptomycin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with streptomycin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "thioridazine", "interaction_type": 75, "interaction_text": "The serum concentration of thioridazine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Almasilate", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "alclometasone", "interaction_type": 75, "interaction_text": "The serum concentration of alclometasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "metrizamide", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with metrizamide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Rufinamide.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Melatonin", "interaction_type": 75, "interaction_text": "The serum concentration of Melatonin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "progesterone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with progesterone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Pimecrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Pimecrolimus can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pyrazinamide", "interaction_type": 75, "interaction_text": "The serum concentration of pyrazinamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ciclesonide", "interaction_type": 75, "interaction_text": "The serum concentration of Ciclesonide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "aminophylline", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with aminophylline.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "mitotane", "drug2": "Fesoterodine", "interaction_type": 75, "interaction_text": "The serum concentration of Fesoterodine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ipratropium", "interaction_type": 75, "interaction_text": "The serum concentration of ipratropium can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "olanzapine", "interaction_type": 75, "interaction_text": "The serum concentration of olanzapine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "pyrazinamide", "interaction_type": 75, "interaction_text": "The serum concentration of pyrazinamide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "secobarbital", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Imidafenacin", "interaction_type": 75, "interaction_text": "The serum concentration of Imidafenacin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "mitotane", "drug2": "domperidone", "interaction_type": 75, "interaction_text": "The serum concentration of domperidone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "granisetron", "interaction_type": 75, "interaction_text": "The serum concentration of granisetron can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clonazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clonazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "metoprolol", "interaction_type": 75, "interaction_text": "The serum concentration of metoprolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE DINITRATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "temazepam", "interaction_type": 75, "interaction_text": "The serum concentration of temazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "STIRIPENTOL", "interaction_type": 75, "interaction_text": "The serum concentration of STIRIPENTOL can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tolbutamide", "interaction_type": 75, "interaction_text": "The serum concentration of tolbutamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "orlistat", "drug2": "lorazepam", "interaction_type": 75, "interaction_text": "The serum concentration of lorazepam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "orlistat", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "osimertinib", "drug2": "lomefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of lomefloxacin can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "famotidine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Bosentan", "interaction_type": 75, "interaction_text": "The serum concentration of Bosentan can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "KETAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of KETAZOLAM can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "quazepam", "interaction_type": 75, "interaction_text": "The serum concentration of quazepam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Sitagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Sitagliptin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "erythromycin", "interaction_type": 75, "interaction_text": "The serum concentration of erythromycin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tazarotene", "interaction_type": 75, "interaction_text": "The serum concentration of tazarotene can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with cholic acid.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Candesartan cilexetil", "interaction_type": 75, "interaction_text": "The serum concentration of Candesartan cilexetil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "primidone", "interaction_type": 75, "interaction_text": "The serum concentration of primidone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "indinavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "methenamine", "drug2": "mecamylamine", "interaction_type": 75, "interaction_text": "The serum concentration of mecamylamine can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "oxacillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "trientine", "drug2": "Magnesium salicylate", "interaction_type": 75, "interaction_text": "The serum concentration of Magnesium salicylate can be decreased when it is combined with trientine.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "ampicillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "thiopental", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "tiagabine", "interaction_type": 75, "interaction_text": "The serum concentration of tiagabine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cocaine", "interaction_type": 75, "interaction_text": "The serum concentration of cocaine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ketobemidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ketobemidone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "SERATRODAST", "interaction_type": 75, "interaction_text": "The serum concentration of SERATRODAST can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "quinapril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "orlistat", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "calcitriol", "interaction_type": 75, "interaction_text": "The serum concentration of calcitriol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "streptozocin", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with streptozocin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "eperisone", "interaction_type": 75, "interaction_text": "The serum concentration of eperisone can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ruxolitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ruxolitinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "piperacillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "piperacillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "Trometamol", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 75, "interaction_text": "The serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dehydroepiandrosterone", "interaction_type": 75, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "primidone", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "primidone", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Enalaprilat", "interaction_type": 75, "interaction_text": "The serum concentration of Enalaprilat can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "topiramate", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nicardipine", "interaction_type": 75, "interaction_text": "The serum concentration of nicardipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "STIRIPENTOL", "interaction_type": 75, "interaction_text": "The serum concentration of STIRIPENTOL can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "risperidone", "interaction_type": 75, "interaction_text": "The serum concentration of risperidone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "duloxetine", "interaction_type": 75, "interaction_text": "The serum concentration of duloxetine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "isoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of isoflurane can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "epinastine", "interaction_type": 75, "interaction_text": "The serum concentration of epinastine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dolasetron", "interaction_type": 75, "interaction_text": "The serum concentration of dolasetron can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "orlistat", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rupatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Rupatadine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Lisdexamfetamine", "interaction_type": 75, "interaction_text": "The serum concentration of Lisdexamfetamine can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "piperacillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Aluminium", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Arbekacin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with Arbekacin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "diphenhydramine", "interaction_type": 75, "interaction_text": "The serum concentration of diphenhydramine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE MONONITRATE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "tolterodine", "interaction_type": 75, "interaction_text": "The serum concentration of tolterodine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "fenofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of fenofibrate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "penicillin g", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "topiramate", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "orlistat", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Gatifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gatifloxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "methyltestosterone", "interaction_type": 75, "interaction_text": "The serum concentration of methyltestosterone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "mitotane", "drug2": "Valbenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Valbenazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "primidone", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Bexarotene", "interaction_type": 75, "interaction_text": "The serum concentration of Bexarotene can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Rupatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Rupatadine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "vindesine", "interaction_type": 75, "interaction_text": "The serum concentration of vindesine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Sodium phosphate monobasic", "interaction_type": 75, "interaction_text": "The serum concentration of Sodium phosphate monobasic can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "primidone", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "trientine", "interaction_type": 75, "interaction_text": "The serum concentration of trientine can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "ampicillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "chlorphenesin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with chlorphenesin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Pioglitazone", "interaction_type": 75, "interaction_text": "The serum concentration of Pioglitazone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "sulfinpyrazone", "interaction_type": 75, "interaction_text": "The serum concentration of sulfinpyrazone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "docetaxel", "interaction_type": 75, "interaction_text": "The serum concentration of docetaxel can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "epoprostenol", "interaction_type": 75, "interaction_text": "The serum concentration of epoprostenol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "vinblastine", "interaction_type": 75, "interaction_text": "The serum concentration of vinblastine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Artemether", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Bosentan", "drug2": "oxybutynin", "interaction_type": 75, "interaction_text": "The serum concentration of oxybutynin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "diethylcarbamazine", "interaction_type": 75, "interaction_text": "The serum concentration of diethylcarbamazine can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "VERAPAMIL", "interaction_type": 75, "interaction_text": "The serum concentration of VERAPAMIL can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ergocalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of ergocalciferol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Eszopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of Eszopiclone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "chloroxylenol", "interaction_type": 75, "interaction_text": "The serum concentration of chloroxylenol can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "dexlansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of dexlansoprazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ziprasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ziprasidone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "codeine", "interaction_type": 75, "interaction_text": "The serum concentration of codeine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with acetaminophen.", "severity": 2}
{"drug1": "thiamylal", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Arbekacin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Arbekacin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "levodopa", "interaction_type": 75, "interaction_text": "The serum concentration of levodopa can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "digoxin", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with digoxin.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ambroxol", "interaction_type": 75, "interaction_text": "The serum concentration of ambroxol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "VERAPAMIL", "interaction_type": 75, "interaction_text": "The serum concentration of VERAPAMIL can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "DEFLAZACORT", "interaction_type": 75, "interaction_text": "The serum concentration of DEFLAZACORT can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Reboxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Reboxetine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with simvastatin.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Torasemide", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with Torasemide.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "estriol", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with estriol.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Artemether", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "antipyrine", "interaction_type": 75, "interaction_text": "The serum concentration of antipyrine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "allylestrenol", "interaction_type": 75, "interaction_text": "The serum concentration of allylestrenol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Apixaban", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Arbekacin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Arbekacin.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Rufinamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "malathion", "interaction_type": 75, "interaction_text": "The serum concentration of malathion can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "acebutolol", "interaction_type": 75, "interaction_text": "The serum concentration of acebutolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Cariprazine", "interaction_type": 75, "interaction_text": "The serum concentration of Cariprazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "chlorzoxazone", "interaction_type": 75, "interaction_text": "The serum concentration of chlorzoxazone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "amprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of amprenavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Asenapine", "interaction_type": 75, "interaction_text": "The serum concentration of Asenapine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "docetaxel", "interaction_type": 75, "interaction_text": "The serum concentration of docetaxel can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Propoxyphene napsylate", "interaction_type": 75, "interaction_text": "The serum concentration of Propoxyphene napsylate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Lacidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lacidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Efonidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Efonidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Amfepramone", "interaction_type": 75, "interaction_text": "The serum concentration of Amfepramone can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cilnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of cilnidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Benidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Benidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Azelnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Azelnidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "oxacillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "budesonide", "interaction_type": 75, "interaction_text": "The serum concentration of budesonide can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nimesulide", "interaction_type": 75, "interaction_text": "The serum concentration of nimesulide can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Levobupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Levobupivacaine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "letrozole", "interaction_type": 75, "interaction_text": "The serum concentration of letrozole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Tixocortol.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "tolterodine", "interaction_type": 75, "interaction_text": "The serum concentration of tolterodine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "topotecan", "interaction_type": 75, "interaction_text": "The serum concentration of topotecan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vardenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Vardenafil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Aliskiren", "interaction_type": 75, "interaction_text": "The serum concentration of Aliskiren can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "dorzolamide", "interaction_type": 75, "interaction_text": "The serum concentration of dorzolamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "pantoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of pantoprazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "reserpine", "interaction_type": 75, "interaction_text": "The serum concentration of reserpine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "cisplatin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with cisplatin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Eletriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Eletriptan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "orlistat", "drug2": "retinol", "interaction_type": 75, "interaction_text": "The serum concentration of retinol can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "orlistat", "drug2": "VITAMIN E", "interaction_type": 75, "interaction_text": "The serum concentration of VITAMIN E can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Ecabet", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "allylestrenol", "interaction_type": 75, "interaction_text": "The serum concentration of allylestrenol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ticlopidine", "interaction_type": 75, "interaction_text": "The serum concentration of ticlopidine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "antipyrine", "interaction_type": 75, "interaction_text": "The serum concentration of antipyrine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Prostaglandin E2", "interaction_type": 75, "interaction_text": "The serum concentration of Prostaglandin E2 can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ceritinib", "interaction_type": 75, "interaction_text": "The serum concentration of ceritinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "hydroxyamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of hydroxyamphetamine can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "docetaxel", "interaction_type": 75, "interaction_text": "The serum concentration of docetaxel can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "gemfibrozil", "interaction_type": 75, "interaction_text": "The serum concentration of gemfibrozil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "paramethasone", "interaction_type": 75, "interaction_text": "The serum concentration of paramethasone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "SERATRODAST", "interaction_type": 75, "interaction_text": "The serum concentration of SERATRODAST can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "CORTISONE ACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of CORTISONE ACETATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "cholic acid", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with cholic acid.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with Olsalazine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Artemether", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "enalapril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Bendamustine", "interaction_type": 75, "interaction_text": "The serum concentration of Bendamustine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Oritavancin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Oritavancin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "hydroxyamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of hydroxyamphetamine can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "piperacillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "nevirapine", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "methenamine", "drug2": "AMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of AMPHETAMINE can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "methyltestosterone", "interaction_type": 75, "interaction_text": "The serum concentration of methyltestosterone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "enalapril", "interaction_type": 75, "interaction_text": "The serum concentration of enalapril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Iloperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Iloperidone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "thiotepa", "interaction_type": 75, "interaction_text": "The serum concentration of thiotepa can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Enasidenib", "interaction_type": 75, "interaction_text": "The serum concentration of Enasidenib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Olsalazine", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with Olsalazine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "benzyl alcohol", "interaction_type": 75, "interaction_text": "The serum concentration of benzyl alcohol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "promethazine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "benazepril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "topiramate", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Venetoclax", "interaction_type": 75, "interaction_text": "The serum concentration of Venetoclax can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "amobarbital", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "topiramate", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Fulvestrant", "interaction_type": 75, "interaction_text": "The serum concentration of Fulvestrant can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Reboxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Reboxetine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "temazepam", "interaction_type": 75, "interaction_text": "The serum concentration of temazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 75, "interaction_text": "The serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Rupatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Rupatadine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "trazodone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with trazodone.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "orlistat", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "cefdinir", "interaction_type": 75, "interaction_text": "The serum concentration of cefdinir can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "vinorelbine", "interaction_type": 75, "interaction_text": "The serum concentration of vinorelbine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "kanamycin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with kanamycin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "azlocillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "naloxone", "interaction_type": 75, "interaction_text": "The serum concentration of naloxone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "penicillin v", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Aluminium", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "glyburide", "interaction_type": 75, "interaction_text": "The serum concentration of glyburide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "sulfamethoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfamethoxazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "topotecan", "interaction_type": 75, "interaction_text": "The serum concentration of topotecan can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cerulenin", "interaction_type": 75, "interaction_text": "The serum concentration of cerulenin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "promethazine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Indacaterol", "interaction_type": 75, "interaction_text": "The serum concentration of Indacaterol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "SERATRODAST", "interaction_type": 75, "interaction_text": "The serum concentration of SERATRODAST can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ketobemidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ketobemidone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "indomethacin", "interaction_type": 75, "interaction_text": "The serum concentration of indomethacin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Paritaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Paritaprevir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "famotidine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dihydroergotamine", "interaction_type": 75, "interaction_text": "The serum concentration of dihydroergotamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "amitriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of amitriptyline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Prasugrel", "interaction_type": 75, "interaction_text": "The serum concentration of Prasugrel can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Silodosin", "interaction_type": 75, "interaction_text": "The serum concentration of Silodosin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Tapentadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tapentadol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Alogliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Alogliptin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "penicillin v", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "felbamate", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Bosentan", "interaction_type": 75, "interaction_text": "The serum concentration of Bosentan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "methoxsalen", "interaction_type": 75, "interaction_text": "The serum concentration of methoxsalen can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Debrisoquine", "interaction_type": 75, "interaction_text": "The serum concentration of Debrisoquine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "podophyllotoxin", "interaction_type": 75, "interaction_text": "The serum concentration of podophyllotoxin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "orphenadrine", "interaction_type": 75, "interaction_text": "The serum concentration of orphenadrine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "sparfloxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with sparfloxacin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mifepristone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with mifepristone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lenvatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lenvatinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "thiabendazole", "interaction_type": 75, "interaction_text": "The serum concentration of thiabendazole can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Apixaban", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "chloroquine", "drug2": "PYRANTEL", "interaction_type": 75, "interaction_text": "The serum concentration of PYRANTEL can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "cisapride", "interaction_type": 75, "interaction_text": "The serum concentration of cisapride can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "suramin", "interaction_type": 75, "interaction_text": "The serum concentration of suramin can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "ranitidine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "lidocaine", "interaction_type": 75, "interaction_text": "The serum concentration of lidocaine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "venlafaxine", "interaction_type": 75, "interaction_text": "The serum concentration of venlafaxine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Iloperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Iloperidone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "primidone", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "amikacin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with amikacin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fidaxomicin", "interaction_type": 75, "interaction_text": "The serum concentration of Fidaxomicin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "osimertinib", "drug2": "resveratrol", "interaction_type": 75, "interaction_text": "The serum concentration of resveratrol can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "barnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of barnidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "amikacin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with amikacin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fluciclovine (18F)", "interaction_type": 75, "interaction_text": "The serum concentration of Fluciclovine (18F) can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "primidone", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROXYPROGESTERONE CAPROATE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "modafinil", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "disulfiram", "interaction_type": 75, "interaction_text": "The serum concentration of disulfiram can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Perospirone", "interaction_type": 75, "interaction_text": "The serum concentration of Perospirone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "finasteride", "interaction_type": 75, "interaction_text": "The serum concentration of finasteride can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "mitotane", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "methyldopa", "interaction_type": 75, "interaction_text": "The serum concentration of methyldopa can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Almasilate", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with alclometasone.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "labetalol", "interaction_type": 75, "interaction_text": "The serum concentration of labetalol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "pentoxifylline", "interaction_type": 75, "interaction_text": "The serum concentration of pentoxifylline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Palonosetron", "interaction_type": 75, "interaction_text": "The serum concentration of Palonosetron can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Halofantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Halofantrine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "mirtazapine", "interaction_type": 75, "interaction_text": "The serum concentration of mirtazapine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "methoxsalen", "interaction_type": 75, "interaction_text": "The serum concentration of methoxsalen can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "estriol", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with estriol.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Bosentan", "interaction_type": 75, "interaction_text": "The serum concentration of Bosentan can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "tolfenamic acid", "interaction_type": 75, "interaction_text": "The serum concentration of tolfenamic acid can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "SULFAMOXOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SULFAMOXOLE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE MONONITRATE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "glyburide", "interaction_type": 75, "interaction_text": "The serum concentration of glyburide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "sulfamethoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfamethoxazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "mitotane", "drug2": "donepezil", "interaction_type": 75, "interaction_text": "The serum concentration of donepezil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "oxazepam", "interaction_type": 75, "interaction_text": "The serum concentration of oxazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "clofazimine", "interaction_type": 75, "interaction_text": "The serum concentration of clofazimine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Olopatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Olopatadine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "orlistat", "drug2": "Calcifediol", "interaction_type": 75, "interaction_text": "The serum concentration of Calcifediol can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "glimepiride", "interaction_type": 75, "interaction_text": "The serum concentration of glimepiride can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ciclesonide", "interaction_type": 75, "interaction_text": "The serum concentration of Ciclesonide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "osimertinib", "drug2": "maprotiline", "interaction_type": 75, "interaction_text": "The serum concentration of maprotiline can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "felbamate", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "liothyronine", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with liothyronine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "mitotane", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Telithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of Telithromycin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "amprenavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "raloxifene", "interaction_type": 75, "interaction_text": "The serum concentration of raloxifene can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "celecoxib", "interaction_type": 75, "interaction_text": "The serum concentration of celecoxib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "felbamate", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "xylometazoline", "interaction_type": 75, "interaction_text": "The serum concentration of xylometazoline can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "risperidone", "interaction_type": 75, "interaction_text": "The serum concentration of risperidone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dextromethorphan", "interaction_type": 75, "interaction_text": "The serum concentration of dextromethorphan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nateglinide", "interaction_type": 75, "interaction_text": "The serum concentration of nateglinide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lornoxicam", "interaction_type": 75, "interaction_text": "The serum concentration of Lornoxicam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "donepezil", "interaction_type": 75, "interaction_text": "The serum concentration of donepezil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "glyburide", "interaction_type": 75, "interaction_text": "The serum concentration of glyburide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "sulfamethoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfamethoxazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Cinacalcet", "interaction_type": 75, "interaction_text": "The serum concentration of Cinacalcet can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "labetalol", "interaction_type": 75, "interaction_text": "The serum concentration of labetalol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Vardenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Vardenafil can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "zalcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of zalcitabine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Fulvestrant", "interaction_type": 75, "interaction_text": "The serum concentration of Fulvestrant can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "benzyl alcohol", "interaction_type": 75, "interaction_text": "The serum concentration of benzyl alcohol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "CABAZITAXEL", "interaction_type": 75, "interaction_text": "The serum concentration of CABAZITAXEL can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "chenodeoxycholic acid", "interaction_type": 75, "interaction_text": "The serum concentration of chenodeoxycholic acid can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "mitotane", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "valsartan", "interaction_type": 75, "interaction_text": "The serum concentration of valsartan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Remikiren", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Trametinib", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Trametinib.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Delavirdine.", "severity": 2}
{"drug1": "ampicillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "ampicillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with CLOCORTOLONE.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "dapsone", "interaction_type": 75, "interaction_text": "The serum concentration of dapsone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "aminoglutethimide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with aminoglutethimide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "NAPROXEN", "interaction_type": 75, "interaction_text": "The serum concentration of NAPROXEN can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with Levoleucovorin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Candesartan cilexetil", "interaction_type": 75, "interaction_text": "The serum concentration of Candesartan cilexetil can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "primidone", "interaction_type": 75, "interaction_text": "The serum concentration of primidone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nitric oxide", "interaction_type": 75, "interaction_text": "The serum concentration of nitric oxide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Artemether", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Liotrix", "interaction_type": 75, "interaction_text": "The serum concentration of Liotrix can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 75, "interaction_text": "The serum concentration of PSEUDOEPHEDRINE can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "alfuzosin", "interaction_type": 75, "interaction_text": "The serum concentration of alfuzosin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "diltiazem", "interaction_type": 75, "interaction_text": "The serum concentration of diltiazem can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "BISOPROLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BISOPROLOL can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "trandolapril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "etoposide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with etoposide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "tolbutamide", "interaction_type": 75, "interaction_text": "The serum concentration of tolbutamide can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ranitidine", "interaction_type": 75, "interaction_text": "The serum concentration of ranitidine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dapsone", "interaction_type": 75, "interaction_text": "The serum concentration of dapsone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "epinastine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "metyrapone", "interaction_type": 75, "interaction_text": "The serum concentration of metyrapone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Quinine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Quinine.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "secobarbital", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Trometamol", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Belinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Belinostat can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Suvorexant", "interaction_type": 75, "interaction_text": "The serum concentration of Suvorexant can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "primidone", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with AMPHETAMINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Mirabegron", "interaction_type": 75, "interaction_text": "The serum concentration of Mirabegron can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "diltiazem", "interaction_type": 75, "interaction_text": "The serum concentration of diltiazem can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "alfuzosin", "interaction_type": 75, "interaction_text": "The serum concentration of alfuzosin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "topiramate", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "osimertinib", "drug2": "betaxolol", "interaction_type": 75, "interaction_text": "The serum concentration of betaxolol can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "doxepin", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Voxilaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Voxilaprevir can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "TASOSARTAN", "interaction_type": 75, "interaction_text": "The serum concentration of TASOSARTAN can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nadolol", "interaction_type": 75, "interaction_text": "The serum concentration of nadolol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Levetiracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Levetiracetam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "bromocriptine", "interaction_type": 75, "interaction_text": "The serum concentration of bromocriptine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with mitoxantrone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "mitoxantrone", "interaction_type": 75, "interaction_text": "The serum concentration of mitoxantrone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cyclophosphamide", "interaction_type": 75, "interaction_text": "The serum concentration of cyclophosphamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "ethanol", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "phenytoin", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "zalcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of zalcitabine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Caspofungin", "interaction_type": 75, "interaction_text": "The serum concentration of Caspofungin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with cinoxacin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clindamycin", "interaction_type": 75, "interaction_text": "The serum concentration of clindamycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "oxymorphone", "interaction_type": 75, "interaction_text": "The serum concentration of oxymorphone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "zopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of zopiclone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "testosterone", "interaction_type": 75, "interaction_text": "The serum concentration of testosterone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "triamcinolone", "interaction_type": 75, "interaction_text": "The serum concentration of triamcinolone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "nicardipine", "interaction_type": 75, "interaction_text": "The serum concentration of nicardipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "clorazepate", "interaction_type": 75, "interaction_text": "The serum concentration of clorazepate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Hydrocortamate", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Hydrocortamate.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "finasteride", "interaction_type": 75, "interaction_text": "The serum concentration of finasteride can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "streptomycin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with streptomycin.", "severity": 2}
{"drug1": "Zinc sulfate", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Zinc sulfate.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Trometamol", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Fesoterodine", "interaction_type": 75, "interaction_text": "The serum concentration of Fesoterodine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "Trometamol", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "trientine", "interaction_type": 75, "interaction_text": "The serum concentration of trientine can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Fluticasone furoate", "interaction_type": 75, "interaction_text": "The serum concentration of Fluticasone furoate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "mitotane", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Velpatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Velpatasvir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Ecabet", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "thiamylal", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "penicillin v", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "indapamide", "interaction_type": 75, "interaction_text": "The serum concentration of indapamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Fluticasone furoate", "interaction_type": 75, "interaction_text": "The serum concentration of Fluticasone furoate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "phenytoin", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "famotidine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "nifedipine", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with nifedipine.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with PREDNICARBATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "thioridazine", "interaction_type": 75, "interaction_text": "The serum concentration of thioridazine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "chlorpropamide", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpropamide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "SUFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of SUFENTANIL can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "trimethoprim", "interaction_type": 75, "interaction_text": "The serum concentration of trimethoprim can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "estriol", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with estriol.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "digoxin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with digoxin.", "severity": 2}
{"drug1": "ethanol", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "Darunavir", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Spirapril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with isoproterenol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Salmeterol", "interaction_type": 75, "interaction_text": "The serum concentration of Salmeterol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "oxacillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "diazepam", "interaction_type": 75, "interaction_text": "The serum concentration of diazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Suvorexant", "interaction_type": 75, "interaction_text": "The serum concentration of Suvorexant can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Spirapril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "mitotane", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "disulfiram", "interaction_type": 75, "interaction_text": "The serum concentration of disulfiram can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "diphenhydramine", "interaction_type": 75, "interaction_text": "The serum concentration of diphenhydramine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rotigotine", "interaction_type": 75, "interaction_text": "The serum concentration of Rotigotine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Eplerenone", "interaction_type": 75, "interaction_text": "The serum concentration of Eplerenone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "amprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of amprenavir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "TAMSULOSIN", "interaction_type": 75, "interaction_text": "The serum concentration of TAMSULOSIN can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "zopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of zopiclone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "thiopental", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "oxymorphone", "interaction_type": 75, "interaction_text": "The serum concentration of oxymorphone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clindamycin", "interaction_type": 75, "interaction_text": "The serum concentration of clindamycin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "cilazapril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lumiracoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Lumiracoxib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Retapamulin", "interaction_type": 75, "interaction_text": "The serum concentration of Retapamulin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "orlistat", "drug2": "tizanidine", "interaction_type": 75, "interaction_text": "The serum concentration of tizanidine can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Paritaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Paritaprevir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ketamine", "interaction_type": 75, "interaction_text": "The serum concentration of ketamine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "budesonide", "interaction_type": 75, "interaction_text": "The serum concentration of budesonide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "diazoxide", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with diazoxide.", "severity": 2}
{"drug1": "felbamate", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "vincristine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with vincristine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "celecoxib", "interaction_type": 75, "interaction_text": "The serum concentration of celecoxib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "raloxifene", "interaction_type": 75, "interaction_text": "The serum concentration of raloxifene can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "trazodone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with trazodone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dolasetron", "interaction_type": 75, "interaction_text": "The serum concentration of dolasetron can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of tetracycline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "oxprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of oxprenolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "fenofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of fenofibrate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "selegiline", "interaction_type": 75, "interaction_text": "The serum concentration of selegiline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "tolterodine", "interaction_type": 75, "interaction_text": "The serum concentration of tolterodine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fenofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of fenofibrate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "selegiline", "interaction_type": 75, "interaction_text": "The serum concentration of selegiline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "tolterodine", "interaction_type": 75, "interaction_text": "The serum concentration of tolterodine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clorazepate", "interaction_type": 75, "interaction_text": "The serum concentration of clorazepate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "testosterone", "interaction_type": 75, "interaction_text": "The serum concentration of testosterone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nicardipine", "interaction_type": 75, "interaction_text": "The serum concentration of nicardipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ergocalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of ergocalciferol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "triamcinolone", "interaction_type": 75, "interaction_text": "The serum concentration of triamcinolone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "probenecid", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with probenecid.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Baricitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Baricitinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "mitotane", "drug2": "Imidafenacin", "interaction_type": 75, "interaction_text": "The serum concentration of Imidafenacin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "amprenavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Myostibin", "interaction_type": 75, "interaction_text": "The serum concentration of Myostibin can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "primidone", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dolasetron", "interaction_type": 75, "interaction_text": "The serum concentration of dolasetron can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "quinapril", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Tiotropium", "interaction_type": 75, "interaction_text": "The serum concentration of Tiotropium can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "BISMUTH SUBSALICYLATE", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with BISMUTH SUBSALICYLATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "theobromine", "interaction_type": 75, "interaction_text": "The serum concentration of theobromine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "oxacillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dexlansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of dexlansoprazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "erythromycin", "interaction_type": 75, "interaction_text": "The serum concentration of erythromycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "ursodiol", "interaction_type": 75, "interaction_text": "The serum concentration of ursodiol can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "ritonavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Nedaplatin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Nedaplatin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "cocaine", "interaction_type": 75, "interaction_text": "The serum concentration of cocaine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "tiagabine", "interaction_type": 75, "interaction_text": "The serum concentration of tiagabine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "orlistat", "drug2": "tiagabine", "interaction_type": 75, "interaction_text": "The serum concentration of tiagabine can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "quinapril", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "netilmicin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with netilmicin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of clofibrate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "astemizole", "interaction_type": 75, "interaction_text": "The serum concentration of astemizole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dihydroergotamine", "interaction_type": 75, "interaction_text": "The serum concentration of dihydroergotamine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "amitriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of amitriptyline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "PYRVINIUM", "interaction_type": 75, "interaction_text": "The serum concentration of PYRVINIUM can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Telithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of Telithromycin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Bazedoxifene", "interaction_type": 75, "interaction_text": "The serum concentration of Bazedoxifene can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "oxacillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with isoproterenol.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "manidipine", "interaction_type": 75, "interaction_text": "The serum concentration of manidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cilnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of cilnidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "temazepam", "interaction_type": 75, "interaction_text": "The serum concentration of temazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Azelnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Azelnidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lacidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lacidipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Reboxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Reboxetine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "LEVOBUNOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOBUNOLOL can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "argatroban", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "thiopental", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "Aluminium", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Bosentan", "drug2": "enalapril", "interaction_type": 75, "interaction_text": "The serum concentration of enalapril can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "orlistat", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "digoxin", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with digoxin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "LISURIDE", "interaction_type": 75, "interaction_text": "The serum concentration of LISURIDE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "estrone", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "benazepril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "chenodeoxycholic acid", "interaction_type": 75, "interaction_text": "The serum concentration of chenodeoxycholic acid can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "benzyl alcohol", "interaction_type": 75, "interaction_text": "The serum concentration of benzyl alcohol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "CABAZITAXEL", "interaction_type": 75, "interaction_text": "The serum concentration of CABAZITAXEL can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Spirapril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "Aluminium", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "vinorelbine", "interaction_type": 75, "interaction_text": "The serum concentration of vinorelbine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "propofol", "interaction_type": 75, "interaction_text": "The serum concentration of propofol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "naloxone", "interaction_type": 75, "interaction_text": "The serum concentration of naloxone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ifosfamide", "interaction_type": 75, "interaction_text": "The serum concentration of ifosfamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pergolide", "interaction_type": 75, "interaction_text": "The serum concentration of pergolide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "domperidone", "interaction_type": 75, "interaction_text": "The serum concentration of domperidone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "acebutolol", "interaction_type": 75, "interaction_text": "The serum concentration of acebutolol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "etizolam", "interaction_type": 75, "interaction_text": "The serum concentration of etizolam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "doxepin", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nizatidine", "interaction_type": 75, "interaction_text": "The serum concentration of nizatidine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nafcillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "modafinil", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Neratinib", "interaction_type": 75, "interaction_text": "The serum concentration of Neratinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nefazodone", "interaction_type": 75, "interaction_text": "The serum concentration of nefazodone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Indacaterol", "interaction_type": 75, "interaction_text": "The serum concentration of Indacaterol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dextromethorphan", "interaction_type": 75, "interaction_text": "The serum concentration of dextromethorphan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Caspofungin", "interaction_type": 75, "interaction_text": "The serum concentration of Caspofungin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "tolnaftate", "interaction_type": 75, "interaction_text": "The serum concentration of tolnaftate can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "bromocriptine", "interaction_type": 75, "interaction_text": "The serum concentration of bromocriptine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Vildagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Vildagliptin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "captopril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "ramipril", "interaction_type": 75, "interaction_text": "The serum concentration of ramipril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with flumethasone.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "gentamicin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with gentamicin.", "severity": 2}
{"drug1": "Aluminium", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "primidone", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "etizolam", "interaction_type": 75, "interaction_text": "The serum concentration of etizolam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Indacaterol", "interaction_type": 75, "interaction_text": "The serum concentration of Indacaterol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Suvorexant", "interaction_type": 75, "interaction_text": "The serum concentration of Suvorexant can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "mitotane", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Paritaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Paritaprevir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ombitasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ombitasvir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "calcitriol", "interaction_type": 75, "interaction_text": "The serum concentration of calcitriol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "formestane", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with formestane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Eletriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Eletriptan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "METHAMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of METHAMPHETAMINE can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "tretinoin", "interaction_type": 75, "interaction_text": "The serum concentration of tretinoin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "thiothixene", "interaction_type": 75, "interaction_text": "The serum concentration of thiothixene can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "pantoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of pantoprazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "epinastine", "interaction_type": 75, "interaction_text": "The serum concentration of epinastine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "orlistat", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "modafinil", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "mitotane", "drug2": "Perospirone", "interaction_type": 75, "interaction_text": "The serum concentration of Perospirone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Pregabalin", "interaction_type": 75, "interaction_text": "The serum concentration of Pregabalin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "dextroamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of dextroamphetamine can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "mitotane", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "clotiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clotiazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vardenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Vardenafil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Liotrix", "interaction_type": 75, "interaction_text": "The serum concentration of Liotrix can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dorzolamide", "interaction_type": 75, "interaction_text": "The serum concentration of dorzolamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "mitotane", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROXYPROGESTERONE CAPROATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Levoleucovorin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Levoleucovorin.", "severity": 2}
{"drug1": "mitotane", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Valbenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Valbenazine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Venetoclax", "interaction_type": 75, "interaction_text": "The serum concentration of Venetoclax can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ruxolitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ruxolitinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "methicillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "timolol", "interaction_type": 75, "interaction_text": "The serum concentration of timolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "captopril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Almotriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Almotriptan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Repaglinide", "interaction_type": 75, "interaction_text": "The serum concentration of Repaglinide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Paricalcitol", "interaction_type": 75, "interaction_text": "The serum concentration of Paricalcitol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tinidazole", "interaction_type": 75, "interaction_text": "The serum concentration of tinidazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "chlorphenesin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with chlorphenesin.", "severity": 2}
{"drug1": "mitotane", "drug2": "ticlopidine", "interaction_type": 75, "interaction_text": "The serum concentration of ticlopidine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "azithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of azithromycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "caffeine", "interaction_type": 75, "interaction_text": "The serum concentration of caffeine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "ritonavir", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "estriol", "interaction_type": 75, "interaction_text": "The serum concentration of estriol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "indapamide", "interaction_type": 75, "interaction_text": "The serum concentration of indapamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "chloroquine", "drug2": "thiabendazole", "interaction_type": 75, "interaction_text": "The serum concentration of thiabendazole can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "sulfisoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfisoxazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dicumarol", "interaction_type": 75, "interaction_text": "The serum concentration of dicumarol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "metoprolol", "interaction_type": 75, "interaction_text": "The serum concentration of metoprolol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "mitotane", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clotiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clotiazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Liotrix", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with Liotrix.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "DIHYDROCODEINE", "interaction_type": 75, "interaction_text": "The serum concentration of DIHYDROCODEINE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Dasabuvir", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Dasabuvir.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "gemfibrozil", "interaction_type": 75, "interaction_text": "The serum concentration of gemfibrozil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "famotidine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "quazepam", "interaction_type": 75, "interaction_text": "The serum concentration of quazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "penbutolol", "interaction_type": 75, "interaction_text": "The serum concentration of penbutolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Deferasirox", "interaction_type": 75, "interaction_text": "The serum concentration of Deferasirox can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "KETAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of KETAZOLAM can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nicotine", "interaction_type": 75, "interaction_text": "The serum concentration of nicotine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Cevimeline", "interaction_type": 75, "interaction_text": "The serum concentration of Cevimeline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "flunisolide", "interaction_type": 75, "interaction_text": "The serum concentration of flunisolide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Mometasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Mometasone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "osimertinib", "drug2": "nabumetone", "interaction_type": 75, "interaction_text": "The serum concentration of nabumetone can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "trazodone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with trazodone.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ropinirole", "interaction_type": 75, "interaction_text": "The serum concentration of ropinirole can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "carmustine", "interaction_type": 75, "interaction_text": "The serum concentration of carmustine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "anagrelide", "interaction_type": 75, "interaction_text": "The serum concentration of anagrelide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "primidone", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nitrendipine", "interaction_type": 75, "interaction_text": "The serum concentration of nitrendipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Lomitapide", "interaction_type": 75, "interaction_text": "The serum concentration of Lomitapide can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Spirapril", "interaction_type": 75, "interaction_text": "The serum concentration of Spirapril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Cinacalcet", "interaction_type": 75, "interaction_text": "The serum concentration of Cinacalcet can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sulfamethoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfamethoxazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "cilazapril", "interaction_type": 75, "interaction_text": "The serum concentration of cilazapril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "fenofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of fenofibrate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "IVERMECTIN", "interaction_type": 75, "interaction_text": "The serum concentration of IVERMECTIN can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "selegiline", "interaction_type": 75, "interaction_text": "The serum concentration of selegiline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cisapride", "interaction_type": 75, "interaction_text": "The serum concentration of cisapride can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "loteprednol", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with loteprednol.", "severity": 2}
{"drug1": "lisinopril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "MEPHENTERMINE", "interaction_type": 75, "interaction_text": "The serum concentration of MEPHENTERMINE can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "bumetanide", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with bumetanide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "MOEXIPRIL", "interaction_type": 75, "interaction_text": "The serum concentration of MOEXIPRIL can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "histamine", "interaction_type": 75, "interaction_text": "The serum concentration of histamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "antipyrine", "interaction_type": 75, "interaction_text": "The serum concentration of antipyrine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cytarabine", "interaction_type": 75, "interaction_text": "The serum concentration of cytarabine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "pantoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of pantoprazole can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "riluzole", "interaction_type": 75, "interaction_text": "The serum concentration of riluzole can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ranitidine", "interaction_type": 75, "interaction_text": "The serum concentration of ranitidine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "benzphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of benzphetamine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with mifepristone.", "severity": 2}
{"drug1": "mitotane", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with alclometasone.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "cholic acid", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with cholic acid.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "vindesine", "interaction_type": 75, "interaction_text": "The serum concentration of vindesine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "chloroquine", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Bexarotene", "interaction_type": 75, "interaction_text": "The serum concentration of Bexarotene can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "glucosamine", "interaction_type": 75, "interaction_text": "The serum concentration of glucosamine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with nalidixic acid.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "TROLEANDOMYCIN", "interaction_type": 75, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "orlistat", "drug2": "dihydrotachysterol", "interaction_type": 75, "interaction_text": "The serum concentration of dihydrotachysterol can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "topiramate", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "phenoxybenzamine", "interaction_type": 75, "interaction_text": "The serum concentration of phenoxybenzamine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Remikiren", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Eletriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Eletriptan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pantoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of pantoprazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with tamoxifen.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ampicillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "TROLEANDOMYCIN", "interaction_type": 75, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "primidone", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Eplerenone", "interaction_type": 75, "interaction_text": "The serum concentration of Eplerenone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Sitaxsentan", "interaction_type": 75, "interaction_text": "The serum concentration of Sitaxsentan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "nicotine", "interaction_type": 75, "interaction_text": "The serum concentration of nicotine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "thioridazine", "interaction_type": 75, "interaction_text": "The serum concentration of thioridazine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "orlistat", "drug2": "primidone", "interaction_type": 75, "interaction_text": "The serum concentration of primidone can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with Escitalopram.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "osimertinib", "drug2": "dacarbazine", "interaction_type": 75, "interaction_text": "The serum concentration of dacarbazine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "secobarbital", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fesoterodine", "interaction_type": 75, "interaction_text": "The serum concentration of Fesoterodine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "gentamicin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with gentamicin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "mecamylamine", "interaction_type": 75, "interaction_text": "The serum concentration of mecamylamine can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "DEFLAZACORT", "interaction_type": 75, "interaction_text": "The serum concentration of DEFLAZACORT can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Eslicarbazepine acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Eslicarbazepine acetate can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "gliclazide", "interaction_type": 75, "interaction_text": "The serum concentration of gliclazide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dutasteride", "interaction_type": 75, "interaction_text": "The serum concentration of Dutasteride can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "bicalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of bicalutamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "budesonide", "interaction_type": 75, "interaction_text": "The serum concentration of budesonide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ketamine", "interaction_type": 75, "interaction_text": "The serum concentration of ketamine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "loperamide", "interaction_type": 75, "interaction_text": "The serum concentration of loperamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Trometamol", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Lisdexamfetamine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dasabuvir", "interaction_type": 75, "interaction_text": "The serum concentration of Dasabuvir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "METHSUXIMIDE", "interaction_type": 75, "interaction_text": "The serum concentration of METHSUXIMIDE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Safinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Safinamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "atenolol", "interaction_type": 75, "interaction_text": "The serum concentration of atenolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "penicillin v", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sulconazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "indinavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "Trometamol", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Copanlisib", "interaction_type": 75, "interaction_text": "The serum concentration of Copanlisib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "nevirapine", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "vinblastine", "interaction_type": 75, "interaction_text": "The serum concentration of vinblastine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Deutetrabenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Deutetrabenazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 75, "interaction_text": "The serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with DESONIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "hydroxyamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of hydroxyamphetamine can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "erythromycin", "interaction_type": 75, "interaction_text": "The serum concentration of erythromycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Velpatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Velpatasvir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Tramadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tramadol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "theophylline", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with theophylline.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with oxiconazole.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "primidone", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "azelastine", "interaction_type": 75, "interaction_text": "The serum concentration of azelastine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Pasireotide", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Pasireotide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clofazimine", "interaction_type": 75, "interaction_text": "The serum concentration of clofazimine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "oxazepam", "interaction_type": 75, "interaction_text": "The serum concentration of oxazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "chloroquine", "drug2": "diethylcarbamazine", "interaction_type": 75, "interaction_text": "The serum concentration of diethylcarbamazine can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Frovatriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Frovatriptan can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "amiodarone", "interaction_type": 75, "interaction_text": "The serum concentration of amiodarone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Ecabet", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "primidone", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "MAGNESIUM SULFATE", "interaction_type": 75, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "glyburide", "interaction_type": 75, "interaction_text": "The serum concentration of glyburide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "piperacillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "primidone", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clarithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of clarithromycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lenvatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lenvatinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "estazolam", "interaction_type": 75, "interaction_text": "The serum concentration of estazolam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dantrolene", "interaction_type": 75, "interaction_text": "The serum concentration of dantrolene can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Halofantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Halofantrine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "osimertinib", "drug2": "olanzapine", "interaction_type": 75, "interaction_text": "The serum concentration of olanzapine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "METHSUXIMIDE", "interaction_type": 75, "interaction_text": "The serum concentration of METHSUXIMIDE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "chloramphenicol", "interaction_type": 75, "interaction_text": "The serum concentration of chloramphenicol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "oxaprozin", "interaction_type": 75, "interaction_text": "The serum concentration of oxaprozin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "piperacillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "lansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of lansoprazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with terbinafine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "acarbose", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with acarbose.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Ziprasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ziprasidone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Asenapine", "interaction_type": 75, "interaction_text": "The serum concentration of Asenapine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "ramipril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "sulfamethoxazole", "interaction_type": 75, "interaction_text": "The serum concentration of sulfamethoxazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "VERAPAMIL", "interaction_type": 75, "interaction_text": "The serum concentration of VERAPAMIL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nilutamide", "interaction_type": 75, "interaction_text": "The serum concentration of nilutamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Cinacalcet", "interaction_type": 75, "interaction_text": "The serum concentration of Cinacalcet can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "oxacillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Azelnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Azelnidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "norethindrone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with norethindrone.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "streptomycin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with streptomycin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "DEFLAZACORT", "interaction_type": 75, "interaction_text": "The serum concentration of DEFLAZACORT can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "mitotane", "drug2": "famciclovir", "interaction_type": 75, "interaction_text": "The serum concentration of famciclovir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "vindesine", "interaction_type": 75, "interaction_text": "The serum concentration of vindesine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "trifluoperazine", "interaction_type": 75, "interaction_text": "The serum concentration of trifluoperazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rupatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Rupatadine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Bexarotene", "interaction_type": 75, "interaction_text": "The serum concentration of Bexarotene can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "Velpatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Velpatasvir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "donepezil", "interaction_type": 75, "interaction_text": "The serum concentration of donepezil can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with ROSOXACIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Mephobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Mephobarbital can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "quinapril", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "mitotane", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "thiopental", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "mitotane", "drug2": "Olopatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Olopatadine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "efavirenz", "drug2": "barnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of barnidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Artemether", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "nitrofurantoin", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with nitrofurantoin.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "estrone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "galanthamine", "interaction_type": 75, "interaction_text": "The serum concentration of galanthamine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "losartan", "interaction_type": 75, "interaction_text": "The serum concentration of losartan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Lacidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lacidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "anagrelide", "interaction_type": 75, "interaction_text": "The serum concentration of anagrelide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 75, "interaction_text": "The serum concentration of PSEUDOEPHEDRINE can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Cinacalcet", "interaction_type": 75, "interaction_text": "The serum concentration of Cinacalcet can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "ethanol", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Rimonabant", "interaction_type": 75, "interaction_text": "The serum concentration of Rimonabant can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "piperacillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "benazepril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ethanol", "interaction_type": 75, "interaction_text": "The serum concentration of ethanol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "oxprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of oxprenolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Enasidenib.", "severity": 2}
{"drug1": "thiamylal", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "ampicillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Vilanterol", "interaction_type": 75, "interaction_text": "The serum concentration of Vilanterol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ESMOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of ESMOLOL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Levomefolic acid.", "severity": 2}
{"drug1": "mitotane", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "duloxetine", "interaction_type": 75, "interaction_text": "The serum concentration of duloxetine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "fluoxetine", "interaction_type": 75, "interaction_text": "The serum concentration of fluoxetine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "estrone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "thiopental", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "oxprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of oxprenolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "methotrexate", "drug2": "Sapropterin", "interaction_type": 75, "interaction_text": "The serum concentration of Sapropterin can be decreased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "famotidine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Oritavancin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Oritavancin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Levocetirizine", "interaction_type": 75, "interaction_text": "The serum concentration of Levocetirizine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nefazodone", "interaction_type": 75, "interaction_text": "The serum concentration of nefazodone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "thiamylal", "interaction_type": 75, "interaction_text": "The serum concentration of thiamylal can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "desipramine", "interaction_type": 75, "interaction_text": "The serum concentration of desipramine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "cilazapril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ADINAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of ADINAZOLAM can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "osimertinib", "drug2": "trifluoperazine", "interaction_type": 75, "interaction_text": "The serum concentration of trifluoperazine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "azlocillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Pinaverium", "interaction_type": 75, "interaction_text": "The serum concentration of Pinaverium can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lornoxicam", "interaction_type": 75, "interaction_text": "The serum concentration of Lornoxicam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "etizolam", "interaction_type": 75, "interaction_text": "The serum concentration of etizolam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Sestamibi", "interaction_type": 75, "interaction_text": "The serum concentration of Sestamibi can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "Amfepramone", "interaction_type": 75, "interaction_text": "The serum concentration of Amfepramone can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sibutramine", "interaction_type": 75, "interaction_text": "The serum concentration of sibutramine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with MEPHENTERMINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "gemfibrozil", "interaction_type": 75, "interaction_text": "The serum concentration of gemfibrozil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "OXTRIPHYLLINE", "interaction_type": 75, "interaction_text": "The serum concentration of OXTRIPHYLLINE can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "perphenazine", "interaction_type": 75, "interaction_text": "The serum concentration of perphenazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "loratadine", "interaction_type": 75, "interaction_text": "The serum concentration of loratadine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "histamine", "interaction_type": 75, "interaction_text": "The serum concentration of histamine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "astemizole", "interaction_type": 75, "interaction_text": "The serum concentration of astemizole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of clofibrate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "bromocriptine", "interaction_type": 75, "interaction_text": "The serum concentration of bromocriptine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Dipotassium hydrogen phosphate", "interaction_type": 75, "interaction_text": "The serum concentration of Dipotassium hydrogen phosphate can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Cariprazine", "interaction_type": 75, "interaction_text": "The serum concentration of Cariprazine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "isradipine", "interaction_type": 75, "interaction_text": "The serum concentration of isradipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with rapamycin.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "orlistat", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "piperacillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "azlocillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "niclosamide", "interaction_type": 75, "interaction_text": "The serum concentration of niclosamide can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "nizatidine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "niclosamide", "interaction_type": 75, "interaction_text": "The serum concentration of niclosamide can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "nizatidine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with Glycopyrronium.", "severity": 2}
{"drug1": "metyrapone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with metyrapone.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Rotigotine", "interaction_type": 75, "interaction_text": "The serum concentration of Rotigotine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "efavirenz", "drug2": "isradipine", "interaction_type": 75, "interaction_text": "The serum concentration of isradipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "captopril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Darunavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "aspirin", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with aspirin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clorazepate", "interaction_type": 75, "interaction_text": "The serum concentration of clorazepate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "testosterone", "interaction_type": 75, "interaction_text": "The serum concentration of testosterone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "triamcinolone", "interaction_type": 75, "interaction_text": "The serum concentration of triamcinolone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "amprenavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cytarabine", "interaction_type": 75, "interaction_text": "The serum concentration of cytarabine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "amobarbital", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Rufinamide", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Rufinamide.", "severity": 2}
{"drug1": "Trometamol", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "formoterol", "interaction_type": 75, "interaction_text": "The serum concentration of formoterol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "atenolol", "interaction_type": 75, "interaction_text": "The serum concentration of atenolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "progesterone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with progesterone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "trientine", "interaction_type": 75, "interaction_text": "The serum concentration of trientine can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ritonavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "mitotane", "drug2": "alclometasone", "interaction_type": 75, "interaction_text": "The serum concentration of alclometasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ziprasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ziprasidone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cyclophosphamide", "interaction_type": 75, "interaction_text": "The serum concentration of cyclophosphamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "cabergoline", "interaction_type": 75, "interaction_text": "The serum concentration of cabergoline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "docetaxel", "interaction_type": 75, "interaction_text": "The serum concentration of docetaxel can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "piperacillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "prednisone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with prednisone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Iloperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Iloperidone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "orlistat", "drug2": "estazolam", "interaction_type": 75, "interaction_text": "The serum concentration of estazolam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "estrone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "azithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of azithromycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Eszopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of Eszopiclone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Amrinone", "interaction_type": 75, "interaction_text": "The serum concentration of Amrinone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "famotidine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "primidone", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "efavirenz", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Udenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Udenafil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "KETAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of KETAZOLAM can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Mirabegron", "interaction_type": 75, "interaction_text": "The serum concentration of Mirabegron can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "prazepam", "interaction_type": 75, "interaction_text": "The serum concentration of prazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tenoxicam", "interaction_type": 75, "interaction_text": "The serum concentration of tenoxicam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ramipril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "propoxyphene", "interaction_type": 75, "interaction_text": "The serum concentration of propoxyphene can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "medrysone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with medrysone.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Indacaterol", "interaction_type": 75, "interaction_text": "The serum concentration of Indacaterol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clonazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clonazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Artemether", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "thiamylal", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "meprobamate", "interaction_type": 75, "interaction_text": "The serum concentration of meprobamate can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "timolol", "interaction_type": 75, "interaction_text": "The serum concentration of timolol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "resveratrol", "interaction_type": 75, "interaction_text": "The serum concentration of resveratrol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with LEVOFLOXACIN.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "mitotane", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Eszopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of Eszopiclone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "perphenazine", "interaction_type": 75, "interaction_text": "The serum concentration of perphenazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dihydroergotamine", "interaction_type": 75, "interaction_text": "The serum concentration of dihydroergotamine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nitrendipine", "interaction_type": 75, "interaction_text": "The serum concentration of nitrendipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "chloroquine", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "thioridazine", "interaction_type": 75, "interaction_text": "The serum concentration of thioridazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "modafinil", "interaction_type": 75, "interaction_text": "The serum concentration of modafinil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Almasilate", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "enalapril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Levomilnacipran", "interaction_type": 75, "interaction_text": "The serum concentration of Levomilnacipran can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dehydroepiandrosterone", "interaction_type": 75, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "thiotepa", "interaction_type": 75, "interaction_text": "The serum concentration of thiotepa can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "selegiline", "interaction_type": 75, "interaction_text": "The serum concentration of selegiline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "letrozole", "interaction_type": 75, "interaction_text": "The serum concentration of letrozole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "mitotane", "drug2": "antipyrine", "interaction_type": 75, "interaction_text": "The serum concentration of antipyrine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "allylestrenol", "interaction_type": 75, "interaction_text": "The serum concentration of allylestrenol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Cariprazine", "interaction_type": 75, "interaction_text": "The serum concentration of Cariprazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "piperacillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "vinblastine", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with vinblastine.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "manidipine", "interaction_type": 75, "interaction_text": "The serum concentration of manidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "cyclophosphamide", "interaction_type": 75, "interaction_text": "The serum concentration of cyclophosphamide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Vitamin D3", "interaction_type": 75, "interaction_text": "The serum concentration of Vitamin D3 can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "montelukast", "interaction_type": 75, "interaction_text": "The serum concentration of montelukast can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "chlordiazepoxide", "interaction_type": 75, "interaction_text": "The serum concentration of chlordiazepoxide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "salicylic acid", "interaction_type": 75, "interaction_text": "The serum concentration of salicylic acid can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "bicalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of bicalutamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ESMOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of ESMOLOL can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "CICLOPIROX", "interaction_type": 75, "interaction_text": "The serum concentration of CICLOPIROX can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dutasteride", "interaction_type": 75, "interaction_text": "The serum concentration of Dutasteride can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "moclobemide", "interaction_type": 75, "interaction_text": "The serum concentration of moclobemide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "podophyllotoxin", "interaction_type": 75, "interaction_text": "The serum concentration of podophyllotoxin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "MEPHENTERMINE", "interaction_type": 75, "interaction_text": "The serum concentration of MEPHENTERMINE can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "methotrexate", "interaction_type": 75, "interaction_text": "The serum concentration of methotrexate can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "5-Fluorouracil", "interaction_type": 75, "interaction_text": "The serum concentration of 5-Fluorouracil can be decreased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lumiracoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Lumiracoxib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 75, "interaction_text": "The serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "streptozocin", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with streptozocin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "orlistat", "drug2": "ethotoin", "interaction_type": 75, "interaction_text": "The serum concentration of ethotoin can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Sitagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Sitagliptin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Conivaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Conivaptan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "suprofen", "interaction_type": 75, "interaction_text": "The serum concentration of suprofen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "argatroban", "interaction_type": 75, "interaction_text": "The serum concentration of argatroban can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Pregabalin", "interaction_type": 75, "interaction_text": "The serum concentration of Pregabalin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dapsone", "interaction_type": 75, "interaction_text": "The serum concentration of dapsone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "modafinil", "interaction_type": 75, "interaction_text": "The serum concentration of modafinil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROXYPROGESTERONE CAPROATE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "primidone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "kanamycin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with kanamycin.", "severity": 2}
{"drug1": "Vapreotide", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Vapreotide.", "severity": 2}
{"drug1": "Artemether", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Almasilate", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "amprenavir", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "xylometazoline", "interaction_type": 75, "interaction_text": "The serum concentration of xylometazoline can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Docosahexaenoic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Docosahexaenoic acid can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "dorzolamide", "interaction_type": 75, "interaction_text": "The serum concentration of dorzolamide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dasabuvir", "interaction_type": 75, "interaction_text": "The serum concentration of Dasabuvir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "dextromethorphan", "interaction_type": 75, "interaction_text": "The serum concentration of dextromethorphan can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Vardenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Vardenafil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "propoxyphene", "interaction_type": 75, "interaction_text": "The serum concentration of propoxyphene can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "amobarbital", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "Venetoclax", "interaction_type": 75, "interaction_text": "The serum concentration of Venetoclax can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "risperidone", "interaction_type": 75, "interaction_text": "The serum concentration of risperidone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nateglinide", "interaction_type": 75, "interaction_text": "The serum concentration of nateglinide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with ribostamycin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "SOMATOSTATIN", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with SOMATOSTATIN.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "mitotane", "drug2": "ropinirole", "interaction_type": 75, "interaction_text": "The serum concentration of ropinirole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "methoxsalen", "interaction_type": 75, "interaction_text": "The serum concentration of methoxsalen can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE DINITRATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Trametinib", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Trametinib.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "granisetron", "interaction_type": 75, "interaction_text": "The serum concentration of granisetron can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Bosentan", "interaction_type": 75, "interaction_text": "The serum concentration of Bosentan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "felbamate", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Almasilate", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "chlorpheniramine", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpheniramine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "miconazole", "interaction_type": 75, "interaction_text": "The serum concentration of miconazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "acebutolol", "interaction_type": 75, "interaction_text": "The serum concentration of acebutolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cyclobenzaprine", "interaction_type": 75, "interaction_text": "The serum concentration of cyclobenzaprine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "vindesine", "interaction_type": 75, "interaction_text": "The serum concentration of vindesine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "famciclovir", "interaction_type": 75, "interaction_text": "The serum concentration of famciclovir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Quinine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Quinine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "epoprostenol", "interaction_type": 75, "interaction_text": "The serum concentration of epoprostenol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Silodosin", "interaction_type": 75, "interaction_text": "The serum concentration of Silodosin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Retapamulin", "interaction_type": 75, "interaction_text": "The serum concentration of Retapamulin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Alogliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Alogliptin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "ritonavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "oxacillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Prasugrel", "interaction_type": 75, "interaction_text": "The serum concentration of Prasugrel can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "ALUMINUM SULFATE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with ALUMINUM SULFATE.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Udenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Udenafil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Isavuconazonium", "interaction_type": 75, "interaction_text": "The serum concentration of Isavuconazonium can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "SERTINDOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SERTINDOLE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "spiramycin", "interaction_type": 75, "interaction_text": "The serum concentration of spiramycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Eszopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of Eszopiclone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "trientine", "drug2": "FERRIC CITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of FERRIC CITRATE can be decreased when it is combined with trientine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "nevirapine", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "caffeine", "interaction_type": 75, "interaction_text": "The serum concentration of caffeine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with RIMEXOLONE.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "methicillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "methicillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "Lisdexamfetamine", "interaction_type": 75, "interaction_text": "The serum concentration of Lisdexamfetamine can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "amprenavir", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "famotidine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "indinavir", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ERGOTAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of ERGOTAMINE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "flurazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flurazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Isoflurophate", "interaction_type": 75, "interaction_text": "The serum concentration of Isoflurophate can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "lisinopril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "Darunavir", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "quinapril", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "quinapril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "diltiazem", "interaction_type": 75, "interaction_text": "The serum concentration of diltiazem can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "orlistat", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "alfuzosin", "interaction_type": 75, "interaction_text": "The serum concentration of alfuzosin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "mitotane", "drug2": "IMIQUIMOD", "interaction_type": 75, "interaction_text": "The serum concentration of IMIQUIMOD can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "trimipramine", "interaction_type": 75, "interaction_text": "The serum concentration of trimipramine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "vincristine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with vincristine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Levocetirizine", "interaction_type": 75, "interaction_text": "The serum concentration of Levocetirizine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "amprenavir", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "oxacillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "primidone", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Alogliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Alogliptin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "IMIQUIMOD", "interaction_type": 75, "interaction_text": "The serum concentration of IMIQUIMOD can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "penicillin v", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Prasugrel", "interaction_type": 75, "interaction_text": "The serum concentration of Prasugrel can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "argatroban", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "quinapril", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ximelagatran", "interaction_type": 75, "interaction_text": "The serum concentration of Ximelagatran can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "cytarabine", "interaction_type": 75, "interaction_text": "The serum concentration of cytarabine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Artemether", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "felbamate", "interaction_type": 75, "interaction_text": "The serum concentration of felbamate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Fulvestrant", "interaction_type": 75, "interaction_text": "The serum concentration of Fulvestrant can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "zalcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of zalcitabine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "orlistat", "drug2": "STIRIPENTOL", "interaction_type": 75, "interaction_text": "The serum concentration of STIRIPENTOL can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "orlistat", "drug2": "Eslicarbazepine acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Eslicarbazepine acetate can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "orlistat", "drug2": "PARALDEHYDE", "interaction_type": 75, "interaction_text": "The serum concentration of PARALDEHYDE can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nicotine", "interaction_type": 75, "interaction_text": "The serum concentration of nicotine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "flunisolide", "interaction_type": 75, "interaction_text": "The serum concentration of flunisolide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Cevimeline", "interaction_type": 75, "interaction_text": "The serum concentration of Cevimeline can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "oxaprozin", "interaction_type": 75, "interaction_text": "The serum concentration of oxaprozin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "indapamide", "interaction_type": 75, "interaction_text": "The serum concentration of indapamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Sevelamer", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Sevelamer.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "cyclobenzaprine", "interaction_type": 75, "interaction_text": "The serum concentration of cyclobenzaprine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "nitric oxide", "interaction_type": 75, "interaction_text": "The serum concentration of nitric oxide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "topiramate", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with ribostamycin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Amrinone", "interaction_type": 75, "interaction_text": "The serum concentration of Amrinone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "loratadine", "interaction_type": 75, "interaction_text": "The serum concentration of loratadine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "dihydroergotamine", "interaction_type": 75, "interaction_text": "The serum concentration of dihydroergotamine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "prazepam", "interaction_type": 75, "interaction_text": "The serum concentration of prazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "quazepam", "interaction_type": 75, "interaction_text": "The serum concentration of quazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "perphenazine", "interaction_type": 75, "interaction_text": "The serum concentration of perphenazine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenytoin", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sibutramine", "interaction_type": 75, "interaction_text": "The serum concentration of sibutramine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Propoxyphene napsylate", "interaction_type": 75, "interaction_text": "The serum concentration of Propoxyphene napsylate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "TROLEANDOMYCIN", "interaction_type": 75, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "cimetidine", "interaction_type": 75, "interaction_text": "The serum concentration of cimetidine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "norfloxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with norfloxacin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "primidone", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "PYRANTEL", "interaction_type": 75, "interaction_text": "The serum concentration of PYRANTEL can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "ritonavir", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ciclesonide", "interaction_type": 75, "interaction_text": "The serum concentration of Ciclesonide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "progesterone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with progesterone.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Pioglitazone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ERGOTAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of ERGOTAMINE can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "tizanidine", "interaction_type": 75, "interaction_text": "The serum concentration of tizanidine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "phenindione", "interaction_type": 75, "interaction_text": "The serum concentration of phenindione can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "kanamycin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with kanamycin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "riluzole", "interaction_type": 75, "interaction_text": "The serum concentration of riluzole can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "osimertinib", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "spiramycin", "interaction_type": 75, "interaction_text": "The serum concentration of spiramycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "galanthamine", "interaction_type": 75, "interaction_text": "The serum concentration of galanthamine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "Retapamulin", "interaction_type": 75, "interaction_text": "The serum concentration of Retapamulin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Sitaxsentan", "interaction_type": 75, "interaction_text": "The serum concentration of Sitaxsentan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Sitagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Sitagliptin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "temazepam", "interaction_type": 75, "interaction_text": "The serum concentration of temazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Reboxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Reboxetine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "progesterone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with progesterone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "oxiconazole", "interaction_type": 75, "interaction_text": "The serum concentration of oxiconazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "enalapril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lenvatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lenvatinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with nicardipine.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "dacarbazine", "interaction_type": 75, "interaction_text": "The serum concentration of dacarbazine can be decreased when it is combined with Sorafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "sulpiride", "interaction_type": 75, "interaction_text": "The serum concentration of sulpiride can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "4-aminopyridine", "interaction_type": 75, "interaction_text": "The serum concentration of 4-aminopyridine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Baricitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Baricitinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clofazimine", "interaction_type": 75, "interaction_text": "The serum concentration of clofazimine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "oxazepam", "interaction_type": 75, "interaction_text": "The serum concentration of oxazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "donepezil", "interaction_type": 75, "interaction_text": "The serum concentration of donepezil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "didanosine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with didanosine.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "IVERMECTIN", "interaction_type": 75, "interaction_text": "The serum concentration of IVERMECTIN can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Rufinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Rufinamide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with ribostamycin.", "severity": 2}
{"drug1": "Trometamol", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Copanlisib", "interaction_type": 75, "interaction_text": "The serum concentration of Copanlisib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "fosinopril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Ecabet", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "mitotane", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "venlafaxine", "interaction_type": 75, "interaction_text": "The serum concentration of venlafaxine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "lidocaine", "interaction_type": 75, "interaction_text": "The serum concentration of lidocaine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "roxithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of roxithromycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "vinblastine", "interaction_type": 75, "interaction_text": "The serum concentration of vinblastine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "secobarbital", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "fosinopril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with buprenorphine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "topiramate", "interaction_type": 75, "interaction_text": "The serum concentration of topiramate can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Pioglitazone", "interaction_type": 75, "interaction_text": "The serum concentration of Pioglitazone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with benzphetamine.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with carboplatin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "sulfinpyrazone", "interaction_type": 75, "interaction_text": "The serum concentration of sulfinpyrazone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "liothyronine", "interaction_type": 75, "interaction_text": "The serum concentration of liothyronine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with ciprofloxacin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Deutetrabenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Deutetrabenazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "nalidixic acid", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with nalidixic acid.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Bosentan", "drug2": "lansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of lansoprazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "MEPHENTERMINE", "interaction_type": 75, "interaction_text": "The serum concentration of MEPHENTERMINE can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Glecaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Glecaprevir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Pibrentasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Pibrentasvir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Iloperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Iloperidone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Cariprazine", "interaction_type": 75, "interaction_text": "The serum concentration of Cariprazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "modafinil", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "salicylic acid", "interaction_type": 75, "interaction_text": "The serum concentration of salicylic acid can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "famciclovir", "interaction_type": 75, "interaction_text": "The serum concentration of famciclovir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "mitotane", "drug2": "colchicine", "interaction_type": 75, "interaction_text": "The serum concentration of colchicine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Yohimbine", "interaction_type": 75, "interaction_text": "The serum concentration of Yohimbine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "bezafibrate", "interaction_type": 75, "interaction_text": "The serum concentration of bezafibrate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Salmeterol", "interaction_type": 75, "interaction_text": "The serum concentration of Salmeterol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "trientine", "drug2": "FERRIC PYROPHOSPHATE", "interaction_type": 75, "interaction_text": "The serum concentration of FERRIC PYROPHOSPHATE can be decreased when it is combined with trientine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "malathion", "interaction_type": 75, "interaction_text": "The serum concentration of malathion can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "mitotane", "drug2": "zalcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of zalcitabine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "osimertinib", "drug2": "fluvoxamine", "interaction_type": 75, "interaction_text": "The serum concentration of fluvoxamine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "midazolam", "interaction_type": 75, "interaction_text": "The serum concentration of midazolam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mycophenolate mofetil", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolate mofetil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "chloroxylenol", "interaction_type": 75, "interaction_text": "The serum concentration of chloroxylenol can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "DEFLAZACORT", "interaction_type": 75, "interaction_text": "The serum concentration of DEFLAZACORT can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "histamine", "interaction_type": 75, "interaction_text": "The serum concentration of histamine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "pilocarpine", "interaction_type": 75, "interaction_text": "The serum concentration of pilocarpine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "PRIMAQUINE", "interaction_type": 75, "interaction_text": "The serum concentration of PRIMAQUINE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "orlistat", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "olanzapine", "interaction_type": 75, "interaction_text": "The serum concentration of olanzapine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "atenolol", "interaction_type": 75, "interaction_text": "The serum concentration of atenolol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ipratropium", "interaction_type": 75, "interaction_text": "The serum concentration of ipratropium can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Halobetasol.", "severity": 2}
{"drug1": "osimertinib", "drug2": "clenbuterol", "interaction_type": 75, "interaction_text": "The serum concentration of clenbuterol can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "quinapril", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "mitotane", "drug2": "lansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of lansoprazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Almotriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Almotriptan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "oxacillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "trimethoprim", "interaction_type": 75, "interaction_text": "The serum concentration of trimethoprim can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Paricalcitol", "interaction_type": 75, "interaction_text": "The serum concentration of Paricalcitol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "omeprazole", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "cephradine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with cephradine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Liotrix", "interaction_type": 75, "interaction_text": "The serum concentration of Liotrix can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "vinorelbine", "interaction_type": 75, "interaction_text": "The serum concentration of vinorelbine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Propoxyphene napsylate", "interaction_type": 75, "interaction_text": "The serum concentration of Propoxyphene napsylate can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "quinapril", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "primidone", "drug2": "Eslicarbazepine acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Eslicarbazepine acetate can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "miconazole", "interaction_type": 75, "interaction_text": "The serum concentration of miconazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Eplerenone", "interaction_type": 75, "interaction_text": "The serum concentration of Eplerenone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "amprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of amprenavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "TAMSULOSIN", "interaction_type": 75, "interaction_text": "The serum concentration of TAMSULOSIN can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "SUFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of SUFENTANIL can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "mitotane", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "medrysone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with medrysone.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "ampicillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "propofol", "interaction_type": 75, "interaction_text": "The serum concentration of propofol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Flubendazole", "interaction_type": 75, "interaction_text": "The serum concentration of Flubendazole can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Almasilate", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Rimonabant", "interaction_type": 75, "interaction_text": "The serum concentration of Rimonabant can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Udenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Udenafil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Perospirone", "interaction_type": 75, "interaction_text": "The serum concentration of Perospirone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "diphenhydramine", "interaction_type": 75, "interaction_text": "The serum concentration of diphenhydramine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Pivampicillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with Pivampicillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "hexetidine", "interaction_type": 75, "interaction_text": "The serum concentration of hexetidine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "quinapril", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with difluprednate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Pinaverium", "interaction_type": 75, "interaction_text": "The serum concentration of Pinaverium can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with terbinafine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Pinaverium", "interaction_type": 75, "interaction_text": "The serum concentration of Pinaverium can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "efavirenz", "drug2": "eperisone", "interaction_type": 75, "interaction_text": "The serum concentration of eperisone can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Docosahexaenoic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Docosahexaenoic acid can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Perampanel", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "aminoglutethimide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with aminoglutethimide.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "thiopental", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "vindesine", "interaction_type": 75, "interaction_text": "The serum concentration of vindesine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Propoxyphene napsylate", "interaction_type": 75, "interaction_text": "The serum concentration of Propoxyphene napsylate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Bexarotene", "interaction_type": 75, "interaction_text": "The serum concentration of Bexarotene can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "thioridazine", "interaction_type": 75, "interaction_text": "The serum concentration of thioridazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Almasilate", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Pioglitazone", "interaction_type": 75, "interaction_text": "The serum concentration of Pioglitazone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "Udenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Udenafil can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rupatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Rupatadine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Alitretinoin", "interaction_type": 75, "interaction_text": "The serum concentration of Alitretinoin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "ATOVAQUONE", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with ATOVAQUONE.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rimonabant", "interaction_type": 75, "interaction_text": "The serum concentration of Rimonabant can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "antipyrine", "interaction_type": 75, "interaction_text": "The serum concentration of antipyrine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "allylestrenol", "interaction_type": 75, "interaction_text": "The serum concentration of allylestrenol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "methotrexate", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with methotrexate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "rasagiline", "interaction_type": 75, "interaction_text": "The serum concentration of rasagiline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "azelastine", "interaction_type": 75, "interaction_text": "The serum concentration of azelastine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "nevirapine", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "zopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of zopiclone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Micafungin", "interaction_type": 75, "interaction_text": "The serum concentration of Micafungin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "penicillin g", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clindamycin", "interaction_type": 75, "interaction_text": "The serum concentration of clindamycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "paramethasone", "interaction_type": 75, "interaction_text": "The serum concentration of paramethasone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Anidulafungin", "interaction_type": 75, "interaction_text": "The serum concentration of Anidulafungin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "liothyronine", "interaction_type": 75, "interaction_text": "The serum concentration of liothyronine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "etodolac", "interaction_type": 75, "interaction_text": "The serum concentration of etodolac can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "modafinil", "interaction_type": 75, "interaction_text": "The serum concentration of modafinil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Eletriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Eletriptan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Torasemide", "interaction_type": 75, "interaction_text": "The serum concentration of Torasemide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Valbenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Valbenazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Enasidenib", "interaction_type": 75, "interaction_text": "The serum concentration of Enasidenib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "felbamate", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Perampanel", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "ramipril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "Asenapine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "dextroamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of dextroamphetamine can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "primidone", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Nebivolol", "interaction_type": 75, "interaction_text": "The serum concentration of Nebivolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "promethazine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "maprotiline", "interaction_type": 75, "interaction_text": "The serum concentration of maprotiline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "isoniazid", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with isoniazid.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Fosaprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Fosaprepitant can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rufinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Rufinamide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "osimertinib", "drug2": "zolmitriptan", "interaction_type": 75, "interaction_text": "The serum concentration of zolmitriptan can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Bivalirudin", "interaction_type": 75, "interaction_text": "The serum concentration of Bivalirudin can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "captopril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "primidone", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "quazepam", "interaction_type": 75, "interaction_text": "The serum concentration of quazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "disulfiram", "interaction_type": 75, "interaction_text": "The serum concentration of disulfiram can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "ramipril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "clozapine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with clozapine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Silodosin", "interaction_type": 75, "interaction_text": "The serum concentration of Silodosin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tapentadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tapentadol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "Amfepramone", "interaction_type": 75, "interaction_text": "The serum concentration of Amfepramone can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "EDOXABAN", "interaction_type": 75, "interaction_text": "The serum concentration of EDOXABAN can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "paromomycin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with paromomycin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "roxithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of roxithromycin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "enalapril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Hydrocortamate", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Hydrocortamate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "fosinopril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "thiothixene", "interaction_type": 75, "interaction_text": "The serum concentration of thiothixene can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Safinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Safinamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "streptozocin", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with streptozocin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Halobetasol", "interaction_type": 75, "interaction_text": "The serum concentration of Halobetasol can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "digoxin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with digoxin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Dexfenfluramine", "interaction_type": 75, "interaction_text": "The serum concentration of Dexfenfluramine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Caspofungin", "interaction_type": 75, "interaction_text": "The serum concentration of Caspofungin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with ribostamycin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with testosterone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "Alogliptin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Alogliptin.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "doxepin", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "ALUMINUM OXIDE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with ALUMINUM OXIDE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "primidone", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "topiramate", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "oxacillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "tinidazole", "interaction_type": 75, "interaction_text": "The serum concentration of tinidazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Paricalcitol", "interaction_type": 75, "interaction_text": "The serum concentration of Paricalcitol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Repaglinide", "interaction_type": 75, "interaction_text": "The serum concentration of Repaglinide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "prazepam", "interaction_type": 75, "interaction_text": "The serum concentration of prazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Almotriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Almotriptan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "olanzapine", "interaction_type": 75, "interaction_text": "The serum concentration of olanzapine can be decreased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dapagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Dapagliflozin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "amcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of amcinonide can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "codeine", "interaction_type": 75, "interaction_text": "The serum concentration of codeine can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Levocetirizine", "interaction_type": 75, "interaction_text": "The serum concentration of Levocetirizine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "propoxyphene", "interaction_type": 75, "interaction_text": "The serum concentration of propoxyphene can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "paramethasone", "interaction_type": 75, "interaction_text": "The serum concentration of paramethasone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "CORTISONE ACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of CORTISONE ACETATE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "DOXOFYLLINE", "interaction_type": 75, "interaction_text": "The serum concentration of DOXOFYLLINE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with Levomefolic acid.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Vitamin D3", "interaction_type": 75, "interaction_text": "The serum concentration of Vitamin D3 can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "pentobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of pentobarbital can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "promethazine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "Salmeterol", "interaction_type": 75, "interaction_text": "The serum concentration of Salmeterol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "cinoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of cinoxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ramipril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "captopril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "enoxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with enoxacin.", "severity": 2}
{"drug1": "amprenavir", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "tetracycline", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with tetracycline.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Capsaicin", "interaction_type": 75, "interaction_text": "The serum concentration of Capsaicin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "benzyl alcohol", "interaction_type": 75, "interaction_text": "The serum concentration of benzyl alcohol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "loperamide", "interaction_type": 75, "interaction_text": "The serum concentration of loperamide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "mifepristone", "interaction_type": 75, "interaction_text": "The serum concentration of mifepristone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "orlistat", "drug2": "Rufinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Rufinamide can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "DIHYDROCODEINE", "interaction_type": 75, "interaction_text": "The serum concentration of DIHYDROCODEINE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "naloxone", "interaction_type": 75, "interaction_text": "The serum concentration of naloxone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ifosfamide", "interaction_type": 75, "interaction_text": "The serum concentration of ifosfamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "pergolide", "interaction_type": 75, "interaction_text": "The serum concentration of pergolide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Caspofungin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Fluticasone furoate", "interaction_type": 75, "interaction_text": "The serum concentration of Fluticasone furoate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "leflunomide", "interaction_type": 75, "interaction_text": "The serum concentration of leflunomide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "hesperetin", "interaction_type": 75, "interaction_text": "The serum concentration of hesperetin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "cephradine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with cephradine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "argatroban", "interaction_type": 75, "interaction_text": "The serum concentration of argatroban can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Caspofungin", "interaction_type": 75, "interaction_text": "The serum concentration of Caspofungin can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Midostaurin.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ondansetron", "interaction_type": 75, "interaction_text": "The serum concentration of ondansetron can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "tiagabine", "interaction_type": 75, "interaction_text": "The serum concentration of tiagabine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cocaine", "interaction_type": 75, "interaction_text": "The serum concentration of cocaine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "zonisamide", "interaction_type": 75, "interaction_text": "The serum concentration of zonisamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with atorvastatin.", "severity": 2}
{"drug1": "topiramate", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tolfenamic acid", "interaction_type": 75, "interaction_text": "The serum concentration of tolfenamic acid can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with nefazodone.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "amprenavir", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Vilanterol", "interaction_type": 75, "interaction_text": "The serum concentration of Vilanterol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vecuronium", "interaction_type": 75, "interaction_text": "The serum concentration of Vecuronium can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with calcitriol.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "vinorelbine", "interaction_type": 75, "interaction_text": "The serum concentration of vinorelbine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "doxepin", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "propofol", "interaction_type": 75, "interaction_text": "The serum concentration of propofol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Cariprazine", "interaction_type": 75, "interaction_text": "The serum concentration of Cariprazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with DEFLAZACORT.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "mitotane", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "dihydroergotamine", "interaction_type": 75, "interaction_text": "The serum concentration of dihydroergotamine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "amitriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of amitriptyline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Pioglitazone", "interaction_type": 75, "interaction_text": "The serum concentration of Pioglitazone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "primidone", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "BALSALAZIDE", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with BALSALAZIDE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "domperidone", "interaction_type": 75, "interaction_text": "The serum concentration of domperidone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "pergolide", "interaction_type": 75, "interaction_text": "The serum concentration of pergolide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ifosfamide", "interaction_type": 75, "interaction_text": "The serum concentration of ifosfamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Deferasirox", "interaction_type": 75, "interaction_text": "The serum concentration of Deferasirox can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "orphenadrine", "interaction_type": 75, "interaction_text": "The serum concentration of orphenadrine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "podophyllotoxin", "interaction_type": 75, "interaction_text": "The serum concentration of podophyllotoxin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "histamine", "interaction_type": 75, "interaction_text": "The serum concentration of histamine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "LISURIDE", "interaction_type": 75, "interaction_text": "The serum concentration of LISURIDE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "enalapril", "interaction_type": 75, "interaction_text": "The serum concentration of enalapril can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "clarithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of clarithromycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "triamterene", "interaction_type": 75, "interaction_text": "The serum concentration of triamterene can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "LEVOFLOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOFLOXACIN can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "methicillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "primidone", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Normethadone", "interaction_type": 75, "interaction_text": "The serum concentration of Normethadone can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "primidone", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "doxepin", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "epinastine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sulfinpyrazone", "interaction_type": 75, "interaction_text": "The serum concentration of sulfinpyrazone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "famotidine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ospemifene", "interaction_type": 75, "interaction_text": "The serum concentration of Ospemifene can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "cinoxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with cinoxacin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Olopatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Olopatadine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "dacarbazine", "interaction_type": 75, "interaction_text": "The serum concentration of dacarbazine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "acebutolol", "interaction_type": 75, "interaction_text": "The serum concentration of acebutolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "reserpine", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "bepridil", "interaction_type": 75, "interaction_text": "The serum concentration of bepridil can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "felbamate", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "amitriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of amitriptyline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Levomilnacipran", "interaction_type": 75, "interaction_text": "The serum concentration of Levomilnacipran can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "tolazamide", "interaction_type": 75, "interaction_text": "The serum concentration of tolazamide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Fulvestrant", "interaction_type": 75, "interaction_text": "The serum concentration of Fulvestrant can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "osimertinib", "drug2": "diphenhydramine", "interaction_type": 75, "interaction_text": "The serum concentration of diphenhydramine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "PERINDOPRIL", "interaction_type": 75, "interaction_text": "The serum concentration of PERINDOPRIL can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "quinapril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "ramipril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "trientine", "drug2": "MAGNESIUM SULFATE", "interaction_type": 75, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be decreased when it is combined with trientine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "thiamylal", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "etizolam", "interaction_type": 75, "interaction_text": "The serum concentration of etizolam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Almotriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Almotriptan can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "penicillin g", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "lansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of lansoprazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Prostaglandin E2", "interaction_type": 75, "interaction_text": "The serum concentration of Prostaglandin E2 can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "trimethoprim", "interaction_type": 75, "interaction_text": "The serum concentration of trimethoprim can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Rupatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Rupatadine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Clofarabine", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with Clofarabine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Baricitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Baricitinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Elbasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Elbasvir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Grazoprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Grazoprevir can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "tretinoin", "interaction_type": 75, "interaction_text": "The serum concentration of tretinoin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "epinastine", "interaction_type": 75, "interaction_text": "The serum concentration of epinastine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "calcitriol", "interaction_type": 75, "interaction_text": "The serum concentration of calcitriol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Retigabine", "interaction_type": 75, "interaction_text": "The serum concentration of Retigabine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "tetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of tetracycline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "nizatidine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Tapentadol", "interaction_type": 75, "interaction_text": "The serum concentration of Tapentadol can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "penicillin g", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "phenytoin", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "trazodone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with trazodone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "indapamide", "interaction_type": 75, "interaction_text": "The serum concentration of indapamide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "liothyronine", "interaction_type": 75, "interaction_text": "The serum concentration of liothyronine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "orphenadrine", "interaction_type": 75, "interaction_text": "The serum concentration of orphenadrine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "podophyllotoxin", "interaction_type": 75, "interaction_text": "The serum concentration of podophyllotoxin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "GUANETHIDINE", "drug2": "dextroamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of dextroamphetamine can be decreased when it is combined with GUANETHIDINE.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "piperacillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "Methadyl acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Methadyl acetate can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Artemether", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bazedoxifene", "interaction_type": 75, "interaction_text": "The serum concentration of Bazedoxifene can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "mitotane", "drug2": "Flibanserin", "interaction_type": 75, "interaction_text": "The serum concentration of Flibanserin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "primidone", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Estrone sulfate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Udenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Udenafil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "orlistat", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "methadone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with methadone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "roxithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of roxithromycin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "meropenem", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with meropenem.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "mitotane", "drug2": "Safinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Safinamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Yohimbine", "interaction_type": 75, "interaction_text": "The serum concentration of Yohimbine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "pentamidine", "interaction_type": 75, "interaction_text": "The serum concentration of pentamidine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "thiabendazole", "interaction_type": 75, "interaction_text": "The serum concentration of thiabendazole can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "trientine", "interaction_type": 75, "interaction_text": "The serum concentration of trientine can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Almasilate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "methicillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "ethosuximide", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with ethosuximide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "celecoxib", "interaction_type": 75, "interaction_text": "The serum concentration of celecoxib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lenalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Lenalidomide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "paroxetine", "interaction_type": 75, "interaction_text": "The serum concentration of paroxetine can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Darunavir", "drug2": "paroxetine", "interaction_type": 75, "interaction_text": "The serum concentration of paroxetine can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Darunavir", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "oxacillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "progesterone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with progesterone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "felbamate", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Bevantolol", "interaction_type": 75, "interaction_text": "The serum concentration of Bevantolol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of clofibrate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "astemizole", "interaction_type": 75, "interaction_text": "The serum concentration of astemizole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "azlocillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Darunavir", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "azelastine", "interaction_type": 75, "interaction_text": "The serum concentration of azelastine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "primidone", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Telithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of Telithromycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "mitotane", "drug2": "raloxifene", "interaction_type": 75, "interaction_text": "The serum concentration of raloxifene can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "celecoxib", "interaction_type": 75, "interaction_text": "The serum concentration of celecoxib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "methicillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "dexlansoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of dexlansoprazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "ramipril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Pinaverium", "interaction_type": 75, "interaction_text": "The serum concentration of Pinaverium can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Arbekacin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with Arbekacin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "progesterone", "interaction_type": 75, "interaction_text": "The serum concentration of progesterone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "carisoprodol", "interaction_type": 75, "interaction_text": "The serum concentration of carisoprodol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Delafloxacin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Delafloxacin.", "severity": 2}
{"drug1": "quinapril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "perphenazine", "interaction_type": 75, "interaction_text": "The serum concentration of perphenazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nefazodone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with nefazodone.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Perampanel", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "quinapril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with amcinonide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "metronidazole", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with metronidazole.", "severity": 2}
{"drug1": "ranitidine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Aliskiren", "interaction_type": 75, "interaction_text": "The serum concentration of Aliskiren can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "manidipine", "interaction_type": 75, "interaction_text": "The serum concentration of manidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ERGOTAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of ERGOTAMINE can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "tizanidine", "interaction_type": 75, "interaction_text": "The serum concentration of tizanidine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "benazepril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "topiramate", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Artemether", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Azelnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Azelnidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "cilnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of cilnidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Efonidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Efonidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Lacidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lacidipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Remikiren", "interaction_type": 75, "interaction_text": "The serum concentration of Remikiren can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "alfuzosin", "interaction_type": 75, "interaction_text": "The serum concentration of alfuzosin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Bosentan", "drug2": "loperamide", "interaction_type": 75, "interaction_text": "The serum concentration of loperamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "indinavir", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "mitotane", "drug2": "Bexarotene", "interaction_type": 75, "interaction_text": "The serum concentration of Bexarotene can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "dapsone", "interaction_type": 75, "interaction_text": "The serum concentration of dapsone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dasabuvir", "interaction_type": 75, "interaction_text": "The serum concentration of Dasabuvir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ESMOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of ESMOLOL can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "mitotane", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Cinacalcet", "interaction_type": 75, "interaction_text": "The serum concentration of Cinacalcet can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "Remikiren", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Perampanel", "interaction_type": 75, "interaction_text": "The serum concentration of Perampanel can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ceritinib", "interaction_type": 75, "interaction_text": "The serum concentration of ceritinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "alfuzosin", "interaction_type": 75, "interaction_text": "The serum concentration of alfuzosin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "TASOSARTAN", "interaction_type": 75, "interaction_text": "The serum concentration of TASOSARTAN can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "argatroban", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "lisinopril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "allylestrenol", "interaction_type": 75, "interaction_text": "The serum concentration of allylestrenol can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "doxepin", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "olanzapine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "flurazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flurazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cephalexin", "interaction_type": 75, "interaction_text": "The serum concentration of cephalexin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ERGOTAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of ERGOTAMINE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ospemifene", "interaction_type": 75, "interaction_text": "The serum concentration of Ospemifene can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "orlistat", "drug2": "Delorazepam", "interaction_type": 75, "interaction_text": "The serum concentration of Delorazepam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Eplerenone", "interaction_type": 75, "interaction_text": "The serum concentration of Eplerenone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "amprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of amprenavir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "TAMSULOSIN", "interaction_type": 75, "interaction_text": "The serum concentration of TAMSULOSIN can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "SUFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of SUFENTANIL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "osimertinib", "drug2": "carmustine", "interaction_type": 75, "interaction_text": "The serum concentration of carmustine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "levodopa", "interaction_type": 75, "interaction_text": "The serum concentration of levodopa can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "suramin", "interaction_type": 75, "interaction_text": "The serum concentration of suramin can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "venlafaxine", "interaction_type": 75, "interaction_text": "The serum concentration of venlafaxine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "lidocaine", "interaction_type": 75, "interaction_text": "The serum concentration of lidocaine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "levorphanol", "interaction_type": 75, "interaction_text": "The serum concentration of levorphanol can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "oxacillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "ADINAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of ADINAZOLAM can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Telithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of Telithromycin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "lomefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of lomefloxacin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "PRIMAQUINE", "interaction_type": 75, "interaction_text": "The serum concentration of PRIMAQUINE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "budesonide", "interaction_type": 75, "interaction_text": "The serum concentration of budesonide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "trandolapril", "interaction_type": 75, "interaction_text": "The serum concentration of trandolapril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Aluminium", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "azlocillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ergocalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of ergocalciferol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "penicillin g", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Artemether", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "trazodone", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with trazodone.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "BREXPIPRAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of BREXPIPRAZOLE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "hexylresorcinol", "interaction_type": 75, "interaction_text": "The serum concentration of hexylresorcinol can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "reserpine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ethosuximide", "interaction_type": 75, "interaction_text": "The serum concentration of ethosuximide can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with thalidomide.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "Sugammadex", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Sugammadex.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "mitotane", "drug2": "propofol", "interaction_type": 75, "interaction_text": "The serum concentration of propofol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "cimetidine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with rapamycin.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "primidone", "drug2": "mifepristone", "interaction_type": 75, "interaction_text": "The serum concentration of mifepristone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "topiramate", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "mitotane", "drug2": "IVERMECTIN", "interaction_type": 75, "interaction_text": "The serum concentration of IVERMECTIN can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "dolasetron", "interaction_type": 75, "interaction_text": "The serum concentration of dolasetron can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "tretinoin", "interaction_type": 75, "interaction_text": "The serum concentration of tretinoin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "isoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of isoflurane can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "trimipramine", "interaction_type": 75, "interaction_text": "The serum concentration of trimipramine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "midazolam", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with midazolam.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tixocortol", "interaction_type": 75, "interaction_text": "The serum concentration of Tixocortol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "tetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of tetracycline can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "felbamate", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "lidocaine", "interaction_type": 75, "interaction_text": "The serum concentration of lidocaine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "nevirapine", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "mitotane", "drug2": "azelastine", "interaction_type": 75, "interaction_text": "The serum concentration of azelastine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "tenoxicam", "interaction_type": 75, "interaction_text": "The serum concentration of tenoxicam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Ciclesonide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "HYDROXYPROGESTERONE CAPROATE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROXYPROGESTERONE CAPROATE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "methyldopa", "interaction_type": 75, "interaction_text": "The serum concentration of methyldopa can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "BISOPROLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BISOPROLOL can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Ecabet", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "primidone", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ruxolitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ruxolitinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "mitotane", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Telithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of Telithromycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Ecabet", "interaction_type": 75, "interaction_text": "The serum concentration of Ecabet can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "colchicine", "interaction_type": 75, "interaction_text": "The serum concentration of colchicine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "propoxyphene", "interaction_type": 75, "interaction_text": "The serum concentration of propoxyphene can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Yohimbine", "interaction_type": 75, "interaction_text": "The serum concentration of Yohimbine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "bezafibrate", "interaction_type": 75, "interaction_text": "The serum concentration of bezafibrate can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "pilocarpine", "interaction_type": 75, "interaction_text": "The serum concentration of pilocarpine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "vinblastine", "interaction_type": 75, "interaction_text": "The serum concentration of vinblastine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "propranolol", "interaction_type": 75, "interaction_text": "The serum concentration of propranolol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with vigabatrin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "famotidine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Alogliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Alogliptin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Olopatadine", "interaction_type": 75, "interaction_text": "The serum concentration of Olopatadine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Prasugrel", "interaction_type": 75, "interaction_text": "The serum concentration of Prasugrel can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dehydroepiandrosterone", "interaction_type": 75, "interaction_text": "The serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "azlocillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "cimetidine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Permethrin", "interaction_type": 75, "interaction_text": "The serum concentration of Permethrin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "mebendazole", "interaction_type": 75, "interaction_text": "The serum concentration of mebendazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ospemifene", "interaction_type": 75, "interaction_text": "The serum concentration of Ospemifene can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "methenamine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 75, "interaction_text": "The serum concentration of PSEUDOEPHEDRINE can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Conivaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Conivaptan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Permethrin", "interaction_type": 75, "interaction_text": "The serum concentration of Permethrin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "oxamniquine", "interaction_type": 75, "interaction_text": "The serum concentration of oxamniquine can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with nefazodone.", "severity": 2}
{"drug1": "METHOHEXITAL", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with METHOHEXITAL.", "severity": 2}
{"drug1": "azlocillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Levocetirizine", "interaction_type": 75, "interaction_text": "The serum concentration of Levocetirizine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "mitotane", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "amprenavir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "mitotane", "drug2": "nefazodone", "interaction_type": 75, "interaction_text": "The serum concentration of nefazodone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "fosinopril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "trientine", "interaction_type": 75, "interaction_text": "The serum concentration of trientine can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Suvorexant", "interaction_type": 75, "interaction_text": "The serum concentration of Suvorexant can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "felbamate", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "felbamate", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Sevelamer", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Sevelamer.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "oxaliplatin", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with oxaliplatin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Ecabet", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ciclesonide", "interaction_type": 75, "interaction_text": "The serum concentration of Ciclesonide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "STIRIPENTOL", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with STIRIPENTOL.", "severity": 2}
{"drug1": "thiamylal", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "flutamide", "interaction_type": 75, "interaction_text": "The serum concentration of flutamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "rabeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of rabeprazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "doxepin", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with doxepin.", "severity": 2}
{"drug1": "orlistat", "drug2": "acetazolamide", "interaction_type": 75, "interaction_text": "The serum concentration of acetazolamide can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with triamcinolone.", "severity": 2}
{"drug1": "thiamylal", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "budesonide", "interaction_type": 75, "interaction_text": "The serum concentration of budesonide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "isradipine", "interaction_type": 75, "interaction_text": "The serum concentration of isradipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "argatroban", "interaction_type": 75, "interaction_text": "The serum concentration of argatroban can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "trimeprazine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with trimeprazine.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Remikiren", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "selegiline", "interaction_type": 75, "interaction_text": "The serum concentration of selegiline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Remikiren", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "cilazapril", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Crizotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Crizotinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with Spectinomycin.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "vinorelbine", "interaction_type": 75, "interaction_text": "The serum concentration of vinorelbine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "cisplatin", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with cisplatin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "sulfinpyrazone", "interaction_type": 75, "interaction_text": "The serum concentration of sulfinpyrazone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Retigabine", "interaction_type": 75, "interaction_text": "The serum concentration of Retigabine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Pioglitazone", "interaction_type": 75, "interaction_text": "The serum concentration of Pioglitazone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Eletriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Eletriptan can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "estrone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with amiodarone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Rimonabant", "interaction_type": 75, "interaction_text": "The serum concentration of Rimonabant can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "mitotane", "drug2": "Silodosin", "interaction_type": 75, "interaction_text": "The serum concentration of Silodosin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Alogliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Alogliptin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "orlistat", "drug2": "MAGNESIUM SULFATE", "interaction_type": 75, "interaction_text": "The serum concentration of MAGNESIUM SULFATE can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "primidone", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Fluprednidene.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ADINAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of ADINAZOLAM can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "epinastine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "5-Fluorouracil", "interaction_type": 75, "interaction_text": "The serum concentration of 5-Fluorouracil can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "Trovafloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Trovafloxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "promethazine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Silodosin", "interaction_type": 75, "interaction_text": "The serum concentration of Silodosin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "orlistat", "drug2": "Retigabine", "interaction_type": 75, "interaction_text": "The serum concentration of Retigabine can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "ibuprofen", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with ibuprofen.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "hesperetin", "interaction_type": 75, "interaction_text": "The serum concentration of hesperetin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "trimipramine", "interaction_type": 75, "interaction_text": "The serum concentration of trimipramine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "quinapril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "IMIQUIMOD", "interaction_type": 75, "interaction_text": "The serum concentration of IMIQUIMOD can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "cefdinir", "interaction_type": 75, "interaction_text": "The serum concentration of cefdinir can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "oxacillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ropinirole", "interaction_type": 75, "interaction_text": "The serum concentration of ropinirole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "paramethasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with paramethasone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Raltegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Raltegravir can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "cephalexin", "interaction_type": 75, "interaction_text": "The serum concentration of cephalexin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rivaroxaban", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Rivaroxaban.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sevoflurane", "interaction_type": 75, "interaction_text": "The serum concentration of sevoflurane can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clotiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clotiazepam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dexamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of dexamethasone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "rizatriptan", "interaction_type": 75, "interaction_text": "The serum concentration of rizatriptan can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Eszopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of Eszopiclone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "orlistat", "drug2": "clorazepate", "interaction_type": 75, "interaction_text": "The serum concentration of clorazepate can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "phenytoin", "drug2": "metyrapone", "interaction_type": 75, "interaction_text": "The serum concentration of metyrapone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "carboplatin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with carboplatin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "Romidepsin", "interaction_type": 75, "interaction_text": "The serum concentration of Romidepsin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Artemether", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "MOEXIPRIL", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with MOEXIPRIL.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Baricitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Baricitinib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "betamethasone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with betamethasone.", "severity": 2}
{"drug1": "Apixaban", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "zopiclone", "interaction_type": 75, "interaction_text": "The serum concentration of zopiclone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Dexfenfluramine", "interaction_type": 75, "interaction_text": "The serum concentration of Dexfenfluramine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "osimertinib", "drug2": "tolperisone", "interaction_type": 75, "interaction_text": "The serum concentration of tolperisone can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nizatidine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Cariprazine", "interaction_type": 75, "interaction_text": "The serum concentration of Cariprazine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "chlorzoxazone", "interaction_type": 75, "interaction_text": "The serum concentration of chlorzoxazone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "spiramycin", "interaction_type": 75, "interaction_text": "The serum concentration of spiramycin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "SERTINDOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SERTINDOLE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Apixaban", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Vildagliptin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Vildagliptin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nadolol", "interaction_type": 75, "interaction_text": "The serum concentration of nadolol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "reserpine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Isavuconazonium", "interaction_type": 75, "interaction_text": "The serum concentration of Isavuconazonium can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "epinastine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "efavirenz", "drug2": "phenindione", "interaction_type": 75, "interaction_text": "The serum concentration of phenindione can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "EXEMESTANE", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with EXEMESTANE.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "mycophenolate mofetil", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolate mofetil can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "midazolam", "interaction_type": 75, "interaction_text": "The serum concentration of midazolam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with calcitriol.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "mitotane", "drug2": "Baricitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Baricitinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Trometamol", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "folinic acid", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with folinic acid.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Iloperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Iloperidone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "flunisolide", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with flunisolide.", "severity": 2}
{"drug1": "azlocillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Safinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Safinamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "mitotane", "drug2": "cocaine", "interaction_type": 75, "interaction_text": "The serum concentration of cocaine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "ampicillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Gatifloxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Gatifloxacin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "lamivudine", "interaction_type": 75, "interaction_text": "The serum concentration of lamivudine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nateglinide", "interaction_type": 75, "interaction_text": "The serum concentration of nateglinide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "vigabatrin", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with vigabatrin.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with trimethoprim.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "efavirenz", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "gemcitabine", "interaction_type": 75, "interaction_text": "The serum concentration of gemcitabine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "calcium lactate", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with calcium lactate.", "severity": 2}
{"drug1": "rapamycin", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with rapamycin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "thiamylal", "drug2": "alprenolol", "interaction_type": 75, "interaction_text": "The serum concentration of alprenolol can be decreased when it is combined with thiamylal.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 75, "interaction_text": "The serum concentration of PSEUDOEPHEDRINE can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "letrozole", "interaction_type": 75, "interaction_text": "The serum concentration of letrozole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Levobupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Levobupivacaine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "domperidone", "interaction_type": 75, "interaction_text": "The serum concentration of domperidone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ketoprofen", "interaction_type": 75, "interaction_text": "The serum concentration of ketoprofen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "promethazine", "interaction_type": 75, "interaction_text": "The serum concentration of promethazine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clonazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clonazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "oxybutynin", "interaction_type": 75, "interaction_text": "The serum concentration of oxybutynin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "mitotane", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "methicillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "methoxsalen", "interaction_type": 75, "interaction_text": "The serum concentration of methoxsalen can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "alosetron", "interaction_type": 75, "interaction_text": "The serum concentration of alosetron can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Liotrix", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Liotrix.", "severity": 2}
{"drug1": "ROXATIDINE ACETATE", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "osimertinib", "drug2": "thiothixene", "interaction_type": 75, "interaction_text": "The serum concentration of thiothixene can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "chloroxylenol", "interaction_type": 75, "interaction_text": "The serum concentration of chloroxylenol can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "chloroxine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroxine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Enalaprilat", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Enalaprilat.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "chenodeoxycholic acid", "interaction_type": 75, "interaction_text": "The serum concentration of chenodeoxycholic acid can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "Darunavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "trandolapril", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Dipotassium hydrogen phosphate", "interaction_type": 75, "interaction_text": "The serum concentration of Dipotassium hydrogen phosphate can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sibutramine", "interaction_type": 75, "interaction_text": "The serum concentration of sibutramine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "ifosfamide", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with ifosfamide.", "severity": 2}
{"drug1": "progesterone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with progesterone.", "severity": 2}
{"drug1": "mitotane", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "BISMUTH SUBSALICYLATE", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with BISMUTH SUBSALICYLATE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "Bosentan", "drug2": "BISOPROLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BISOPROLOL can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ampicillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "fosinopril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "felbamate", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "efavirenz", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Avanafil", "interaction_type": 75, "interaction_text": "The serum concentration of Avanafil can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "calcitriol", "interaction_type": 75, "interaction_text": "The serum concentration of calcitriol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "amikacin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with amikacin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Perampanel", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "salicylic acid", "interaction_type": 75, "interaction_text": "The serum concentration of salicylic acid can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with Amfepramone.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "bepridil", "interaction_type": 75, "interaction_text": "The serum concentration of bepridil can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "primidone", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "mitotane", "drug2": "flurazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flurazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "chlordiazepoxide", "interaction_type": 75, "interaction_text": "The serum concentration of chlordiazepoxide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dronabinol", "interaction_type": 75, "interaction_text": "The serum concentration of Dronabinol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "montelukast", "interaction_type": 75, "interaction_text": "The serum concentration of montelukast can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "ERGOTAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of ERGOTAMINE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "triamterene", "interaction_type": 75, "interaction_text": "The serum concentration of triamterene can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "orlistat", "drug2": "Phensuximide", "interaction_type": 75, "interaction_text": "The serum concentration of Phensuximide can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "halcinonide", "interaction_type": 75, "interaction_text": "The serum concentration of halcinonide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "difluprednate", "interaction_type": 75, "interaction_text": "The serum concentration of difluprednate can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "orlistat", "drug2": "Progabide", "interaction_type": 75, "interaction_text": "The serum concentration of Progabide can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "mitotane", "drug2": "diltiazem", "interaction_type": 75, "interaction_text": "The serum concentration of diltiazem can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "alfuzosin", "interaction_type": 75, "interaction_text": "The serum concentration of alfuzosin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "pantoprazole", "interaction_type": 75, "interaction_text": "The serum concentration of pantoprazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Eletriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Eletriptan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "primidone", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "primidone", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "glyburide", "interaction_type": 75, "interaction_text": "The serum concentration of glyburide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "LEVOBUNOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of LEVOBUNOLOL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Metipranolol", "interaction_type": 75, "interaction_text": "The serum concentration of Metipranolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Deutetrabenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Deutetrabenazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "nafcillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Midostaurin", "interaction_type": 75, "interaction_text": "The serum concentration of Midostaurin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "olanzapine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "olanzapine", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Bosentan", "drug2": "vindesine", "interaction_type": 75, "interaction_text": "The serum concentration of vindesine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "paramethasone", "interaction_type": 75, "interaction_text": "The serum concentration of paramethasone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Bexarotene", "interaction_type": 75, "interaction_text": "The serum concentration of Bexarotene can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "CORTISONE ACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of CORTISONE ACETATE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "carboplatin", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with carboplatin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Deutetrabenazine", "interaction_type": 75, "interaction_text": "The serum concentration of Deutetrabenazine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "estriol", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with estriol.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "miconazole", "interaction_type": 75, "interaction_text": "The serum concentration of miconazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with amprenavir.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "PYRVINIUM", "interaction_type": 75, "interaction_text": "The serum concentration of PYRVINIUM can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "chlorpheniramine", "interaction_type": 75, "interaction_text": "The serum concentration of chlorpheniramine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "amiodarone", "interaction_type": 75, "interaction_text": "The serum concentration of amiodarone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Copanlisib", "interaction_type": 75, "interaction_text": "The serum concentration of Copanlisib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "benzyl alcohol", "interaction_type": 75, "interaction_text": "The serum concentration of benzyl alcohol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "CABAZITAXEL", "interaction_type": 75, "interaction_text": "The serum concentration of CABAZITAXEL can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "chenodeoxycholic acid", "interaction_type": 75, "interaction_text": "The serum concentration of chenodeoxycholic acid can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "chloroquine", "drug2": "ampicillin", "interaction_type": 75, "interaction_text": "The serum concentration of ampicillin can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Mirabegron", "interaction_type": 75, "interaction_text": "The serum concentration of Mirabegron can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "ethanol", "interaction_type": 75, "interaction_text": "The serum concentration of ethanol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "cilazapril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with cilazapril.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Gemifloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Gemifloxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "L-thyroxine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with L-thyroxine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "REMIFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of REMIFENTANIL can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "histamine", "interaction_type": 75, "interaction_text": "The serum concentration of histamine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "alclometasone", "interaction_type": 75, "interaction_text": "The serum concentration of alclometasone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ziprasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ziprasidone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cabergoline", "interaction_type": 75, "interaction_text": "The serum concentration of cabergoline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "nimesulide", "interaction_type": 75, "interaction_text": "The serum concentration of nimesulide can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "quinapril", "interaction_type": 75, "interaction_text": "The serum concentration of quinapril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "finasteride", "interaction_type": 75, "interaction_text": "The serum concentration of finasteride can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "estazolam", "interaction_type": 75, "interaction_text": "The serum concentration of estazolam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Ecabet", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Halofantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Halofantrine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dantrolene", "interaction_type": 75, "interaction_text": "The serum concentration of dantrolene can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "dantrolene", "interaction_type": 75, "interaction_text": "The serum concentration of dantrolene can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Halofantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Halofantrine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "estazolam", "interaction_type": 75, "interaction_text": "The serum concentration of estazolam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "finasteride", "interaction_type": 75, "interaction_text": "The serum concentration of finasteride can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "folic acid", "drug2": "primidone", "interaction_type": 75, "interaction_text": "The serum concentration of primidone can be decreased when it is combined with folic acid.", "severity": 2}
{"drug1": "Bosentan", "drug2": "modafinil", "interaction_type": 75, "interaction_text": "The serum concentration of modafinil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with cyclophosphamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "orlistat", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with hydroxyamphetamine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Permethrin", "interaction_type": 75, "interaction_text": "The serum concentration of Permethrin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Fluticasone furoate", "interaction_type": 75, "interaction_text": "The serum concentration of Fluticasone furoate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ospemifene", "interaction_type": 75, "interaction_text": "The serum concentration of Ospemifene can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "erythromycin", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with erythromycin.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Brigatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Brigatinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Apixaban", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "penicillin g", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "thiopental", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Salmeterol", "interaction_type": 75, "interaction_text": "The serum concentration of Salmeterol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "piperacillin", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "cefuroxime", "interaction_type": 75, "interaction_text": "The serum concentration of cefuroxime can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Bazedoxifene", "interaction_type": 75, "interaction_text": "The serum concentration of Bazedoxifene can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with methylprednisolone.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "Isoflurophate", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Isoflurophate.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 75, "interaction_text": "The serum concentration of PSEUDOEPHEDRINE can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "midazolam", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with midazolam.", "severity": 2}
{"drug1": "mitotane", "drug2": "vinorelbine", "interaction_type": 75, "interaction_text": "The serum concentration of vinorelbine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Esomeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Esomeprazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "cholic acid", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with cholic acid.", "severity": 2}
{"drug1": "PIRFENIDONE", "drug2": "Nintedanib", "interaction_type": 75, "interaction_text": "The serum concentration of Nintedanib can be decreased when it is combined with PIRFENIDONE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "modafinil", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "nevirapine", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "TROLEANDOMYCIN", "interaction_type": 75, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Myostibin", "interaction_type": 75, "interaction_text": "The serum concentration of Myostibin can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "efavirenz", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Remikiren", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "sulfinpyrazone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with sulfinpyrazone.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "cabergoline", "interaction_type": 75, "interaction_text": "The serum concentration of cabergoline can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "alclometasone", "interaction_type": 75, "interaction_text": "The serum concentration of alclometasone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "oxamniquine", "interaction_type": 75, "interaction_text": "The serum concentration of oxamniquine can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "topiramate", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCINOLONE ACETONIDE can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "L-glutamic acid", "drug2": "AMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of AMPHETAMINE can be decreased when it is combined with L-glutamic acid.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nitrendipine", "interaction_type": 75, "interaction_text": "The serum concentration of nitrendipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "promazine", "interaction_type": 75, "interaction_text": "The serum concentration of promazine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "primidone", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "IDARUBICIN", "interaction_type": 75, "interaction_text": "The serum concentration of IDARUBICIN can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Spirapril", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "modafinil", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "irbesartan", "interaction_type": 75, "interaction_text": "The serum concentration of irbesartan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with nifedipine.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "mitotane", "drug2": "terbinafine", "interaction_type": 75, "interaction_text": "The serum concentration of terbinafine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ISOSORBIDE MONONITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE MONONITRATE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "carisoprodol", "interaction_type": 75, "interaction_text": "The serum concentration of carisoprodol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "primidone", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "penicillin v", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "primidone", "drug2": "Arotinolol", "interaction_type": 75, "interaction_text": "The serum concentration of Arotinolol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cyclophosphamide", "interaction_type": 75, "interaction_text": "The serum concentration of cyclophosphamide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "toremifene", "interaction_type": 75, "interaction_text": "The serum concentration of toremifene can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "indinavir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Propoxyphene napsylate", "interaction_type": 75, "interaction_text": "The serum concentration of Propoxyphene napsylate can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "epinastine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "granisetron", "interaction_type": 75, "interaction_text": "The serum concentration of granisetron can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "methyltestosterone", "interaction_type": 75, "interaction_text": "The serum concentration of methyltestosterone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE DINITRATE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with nifedipine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "rabeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of rabeprazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "bicalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of bicalutamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dutasteride", "interaction_type": 75, "interaction_text": "The serum concentration of Dutasteride can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "methicillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Sodium phosphate monobasic", "interaction_type": 75, "interaction_text": "The serum concentration of Sodium phosphate monobasic can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Rotigotine", "interaction_type": 75, "interaction_text": "The serum concentration of Rotigotine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "mitotane", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "pimozide", "interaction_type": 75, "interaction_text": "The serum concentration of pimozide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "mitotane", "drug2": "sibutramine", "interaction_type": 75, "interaction_text": "The serum concentration of sibutramine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "sertraline", "interaction_type": 75, "interaction_text": "The serum concentration of sertraline can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "vincristine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with vincristine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "felbamate", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Nintedanib", "interaction_type": 75, "interaction_text": "The serum concentration of Nintedanib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "fleroxacin", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with fleroxacin.", "severity": 2}
{"drug1": "penicillin v", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "estrone", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "efavirenz", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Cis-mdp", "interaction_type": 75, "interaction_text": "The serum concentration of Cis-mdp can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ximelagatran", "interaction_type": 75, "interaction_text": "The serum concentration of Ximelagatran can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "flunitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flunitrazepam can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "DEXMEDETOMIDINE", "interaction_type": 75, "interaction_text": "The serum concentration of DEXMEDETOMIDINE can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "argatroban", "interaction_type": 75, "interaction_text": "The serum concentration of argatroban can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "tacrolimus", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with tacrolimus.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "imipramine", "interaction_type": 75, "interaction_text": "The serum concentration of imipramine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "paromomycin", "drug2": "digoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digoxin can be decreased when it is combined with paromomycin.", "severity": 2}
{"drug1": "thiopental", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "meperidine", "interaction_type": 75, "interaction_text": "The serum concentration of meperidine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "loratadine", "interaction_type": 75, "interaction_text": "The serum concentration of loratadine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "flunisolide", "interaction_type": 75, "interaction_text": "The serum concentration of flunisolide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nicotine", "interaction_type": 75, "interaction_text": "The serum concentration of nicotine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Cevimeline", "interaction_type": 75, "interaction_text": "The serum concentration of Cevimeline can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Cinacalcet.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ciclesonide", "interaction_type": 75, "interaction_text": "The serum concentration of Ciclesonide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "chenodeoxycholic acid", "interaction_type": 75, "interaction_text": "The serum concentration of chenodeoxycholic acid can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with CORTISONE ACETATE.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "sparfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of sparfloxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "KAOLIN", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with KAOLIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ramelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Ramelteon can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "temazepam", "interaction_type": 75, "interaction_text": "The serum concentration of temazepam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "CABAZITAXEL", "interaction_type": 75, "interaction_text": "The serum concentration of CABAZITAXEL can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Reboxetine", "interaction_type": 75, "interaction_text": "The serum concentration of Reboxetine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cytarabine", "interaction_type": 75, "interaction_text": "The serum concentration of cytarabine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "diphenhydramine", "interaction_type": 75, "interaction_text": "The serum concentration of diphenhydramine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Trametinib", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Trametinib.", "severity": 2}
{"drug1": "Almasilate", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "CYCLACILLIN", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with CYCLACILLIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "mitotane", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "osimertinib", "interaction_type": 75, "interaction_text": "The serum concentration of osimertinib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "primidone", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "THYMOL", "interaction_type": 75, "interaction_text": "The serum concentration of THYMOL can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with lansoprazole.", "severity": 2}
{"drug1": "Remikiren", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "Darunavir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "hydromorphone", "interaction_type": 75, "interaction_text": "The serum concentration of hydromorphone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "amitriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of amitriptyline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cytarabine", "interaction_type": 75, "interaction_text": "The serum concentration of cytarabine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "primidone", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "modafinil", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "Gemifloxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Gemifloxacin.", "severity": 2}
{"drug1": "captopril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with captopril.", "severity": 2}
{"drug1": "mitotane", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "mitotane", "drug2": "methyltestosterone", "interaction_type": 75, "interaction_text": "The serum concentration of methyltestosterone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "rapamycin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with rapamycin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Prasugrel", "interaction_type": 75, "interaction_text": "The serum concentration of Prasugrel can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "haloperidol", "interaction_type": 75, "interaction_text": "The serum concentration of haloperidol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "flunisolide", "interaction_type": 75, "interaction_text": "The serum concentration of flunisolide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Cevimeline", "interaction_type": 75, "interaction_text": "The serum concentration of Cevimeline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "nicotine", "interaction_type": 75, "interaction_text": "The serum concentration of nicotine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "epinastine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with hydrocortisone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Paliperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Paliperidone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "topiramate", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Aliskiren", "interaction_type": 75, "interaction_text": "The serum concentration of Aliskiren can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "SUFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of SUFENTANIL can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "modafinil", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with modafinil.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Amrinone", "interaction_type": 75, "interaction_text": "The serum concentration of Amrinone can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "bacampicillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with bacampicillin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Drospirenone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ivacaftor", "interaction_type": 75, "interaction_text": "The serum concentration of Ivacaftor can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "RUCAPARIB", "interaction_type": 75, "interaction_text": "The serum concentration of RUCAPARIB can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Rivaroxaban", "interaction_type": 75, "interaction_text": "The serum concentration of Rivaroxaban can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nelfinavir", "interaction_type": 75, "interaction_text": "The serum concentration of nelfinavir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lenvatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lenvatinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ethylmorphine", "interaction_type": 75, "interaction_text": "The serum concentration of Ethylmorphine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "CHROMIUM", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with CHROMIUM.", "severity": 2}
{"drug1": "lisinopril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "osimertinib", "drug2": "NAPROXEN", "interaction_type": 75, "interaction_text": "The serum concentration of NAPROXEN can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "quinapril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "quinapril", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "quinapril", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Caspofungin", "interaction_type": 75, "interaction_text": "The serum concentration of Caspofungin can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "CARTEOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of CARTEOLOL can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Suvorexant", "interaction_type": 75, "interaction_text": "The serum concentration of Suvorexant can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "KETAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of KETAZOLAM can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "SULBACTAM", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with SULBACTAM.", "severity": 2}
{"drug1": "argatroban", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "mitotane", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "oxacillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "primidone", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Arformoterol", "interaction_type": 75, "interaction_text": "The serum concentration of Arformoterol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Frovatriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Frovatriptan can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lopinavir", "interaction_type": 75, "interaction_text": "The serum concentration of Lopinavir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "prednisone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with prednisone.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Cinacalcet", "interaction_type": 75, "interaction_text": "The serum concentration of Cinacalcet can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Paritaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Paritaprevir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "orlistat", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vandetanib", "interaction_type": 75, "interaction_text": "The serum concentration of Vandetanib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "domperidone", "interaction_type": 75, "interaction_text": "The serum concentration of domperidone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "topiramate", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "topiramate", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "folinic acid", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with folinic acid.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "LUCANTHONE", "interaction_type": 75, "interaction_text": "The serum concentration of LUCANTHONE can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "halothane", "interaction_type": 75, "interaction_text": "The serum concentration of halothane can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "bupropion", "interaction_type": 75, "interaction_text": "The serum concentration of bupropion can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "desipramine", "interaction_type": 75, "interaction_text": "The serum concentration of desipramine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Almotriptan", "interaction_type": 75, "interaction_text": "The serum concentration of Almotriptan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "ethanol", "drug2": "PHENPROCOUMON", "interaction_type": 75, "interaction_text": "The serum concentration of PHENPROCOUMON can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "tinidazole", "interaction_type": 75, "interaction_text": "The serum concentration of tinidazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Paricalcitol", "interaction_type": 75, "interaction_text": "The serum concentration of Paricalcitol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "oxacillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with oxacillin.", "severity": 2}
{"drug1": "ethanol", "drug2": "phenindione", "interaction_type": 75, "interaction_text": "The serum concentration of phenindione can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ALFENTANIL", "interaction_type": 75, "interaction_text": "The serum concentration of ALFENTANIL can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ISOSORBIDE DINITRATE", "interaction_type": 75, "interaction_text": "The serum concentration of ISOSORBIDE DINITRATE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Artemether", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Venetoclax", "interaction_type": 75, "interaction_text": "The serum concentration of Venetoclax can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "granisetron", "interaction_type": 75, "interaction_text": "The serum concentration of granisetron can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "methicillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "DIHYDROCODEINE", "interaction_type": 75, "interaction_text": "The serum concentration of DIHYDROCODEINE can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "liothyronine", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with liothyronine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Almasilate", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "lidocaine", "interaction_type": 75, "interaction_text": "The serum concentration of lidocaine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "estrone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Rilpivirine", "drug2": "DIPHENOXYLATE", "interaction_type": 75, "interaction_text": "The serum concentration of DIPHENOXYLATE can be decreased when it is combined with Rilpivirine.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "bepridil", "interaction_type": 75, "interaction_text": "The serum concentration of bepridil can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ruxolitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ruxolitinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "etodolac", "interaction_type": 75, "interaction_text": "The serum concentration of etodolac can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Paritaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Paritaprevir can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nabumetone", "interaction_type": 75, "interaction_text": "The serum concentration of nabumetone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "D-mannitol", "interaction_type": 75, "interaction_text": "The serum concentration of D-mannitol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "timolol", "interaction_type": 75, "interaction_text": "The serum concentration of timolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Levomefolic acid", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Levomefolic acid.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "ritonavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "DOXOFYLLINE", "interaction_type": 75, "interaction_text": "The serum concentration of DOXOFYLLINE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "ritonavir", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Tenofovir disoproxil", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Tenofovir disoproxil.", "severity": 2}
{"drug1": "Aluminium", "drug2": "fosinopril", "interaction_type": 75, "interaction_text": "The serum concentration of fosinopril can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "alprazolam", "interaction_type": 75, "interaction_text": "The serum concentration of alprazolam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "phenytoin", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "colchicine", "interaction_type": 75, "interaction_text": "The serum concentration of colchicine can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "azlocillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with clotrimazole.", "severity": 2}
{"drug1": "Artemether", "drug2": "Levonorgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of Levonorgestrel can be decreased when it is combined with Artemether.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "thalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of thalidomide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Rifampicin", "interaction_type": 75, "interaction_text": "The serum concentration of Rifampicin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "clomipramine", "interaction_type": 75, "interaction_text": "The serum concentration of clomipramine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "ritonavir", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Remikiren", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Remikiren.", "severity": 2}
{"drug1": "penicillin g", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "topiramate", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with topiramate.", "severity": 2}
{"drug1": "methicillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with Spectinomycin.", "severity": 2}
{"drug1": "secobarbital", "drug2": "Paritaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Paritaprevir can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "albendazole", "interaction_type": 75, "interaction_text": "The serum concentration of albendazole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "lisinopril", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with lisinopril.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "dextromethorphan", "interaction_type": 75, "interaction_text": "The serum concentration of dextromethorphan can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Strontium ranelate", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with Strontium ranelate.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Erismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Erismodegib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "DEFLAZACORT", "interaction_type": 75, "interaction_text": "The serum concentration of DEFLAZACORT can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "testosterone", "interaction_type": 75, "interaction_text": "The serum concentration of testosterone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Udenafil", "interaction_type": 75, "interaction_text": "The serum concentration of Udenafil can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Norelgestromin", "interaction_type": 75, "interaction_text": "The serum concentration of Norelgestromin can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "clenbuterol", "interaction_type": 75, "interaction_text": "The serum concentration of clenbuterol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "phenytoin", "drug2": "diflorasone", "interaction_type": 75, "interaction_text": "The serum concentration of diflorasone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "pentobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of pentobarbital can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ketobemidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ketobemidone can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "codeine", "interaction_type": 75, "interaction_text": "The serum concentration of codeine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Apremilast", "interaction_type": 75, "interaction_text": "The serum concentration of Apremilast can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "promethazine", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with promethazine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Iloperidone", "interaction_type": 75, "interaction_text": "The serum concentration of Iloperidone can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "nefazodone", "interaction_type": 75, "interaction_text": "The serum concentration of nefazodone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dutasteride", "interaction_type": 75, "interaction_text": "The serum concentration of Dutasteride can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "NORGESTIMATE", "interaction_type": 75, "interaction_text": "The serum concentration of NORGESTIMATE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "mitotane", "drug2": "rabeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of rabeprazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "bicalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of bicalutamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "osimertinib", "drug2": "Dexfenfluramine", "interaction_type": 75, "interaction_text": "The serum concentration of Dexfenfluramine can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Sitagliptin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Sitagliptin.", "severity": 2}
{"drug1": "Dabigatran etexilate", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Dabigatran etexilate.", "severity": 2}
{"drug1": "famotidine", "drug2": "indinavir", "interaction_type": 75, "interaction_text": "The serum concentration of indinavir can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "paromomycin", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with paromomycin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "omeprazole", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with omeprazole.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "EXEMESTANE", "interaction_type": 75, "interaction_text": "The serum concentration of EXEMESTANE can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "methazolamide", "drug2": "lithium ion", "interaction_type": 75, "interaction_text": "The serum concentration of lithium ion can be decreased when it is combined with methazolamide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "secobarbital", "drug2": "practolol", "interaction_type": 75, "interaction_text": "The serum concentration of practolol can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "methyltestosterone", "interaction_type": 75, "interaction_text": "The serum concentration of methyltestosterone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "ramipril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with ramipril.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nilvadipine", "interaction_type": 75, "interaction_text": "The serum concentration of nilvadipine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "progesterone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with progesterone.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ezetimibe", "interaction_type": 75, "interaction_text": "The serum concentration of Ezetimibe can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "actinomycin D", "interaction_type": 75, "interaction_text": "The serum concentration of actinomycin D can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "dipyridamole", "interaction_type": 75, "interaction_text": "The serum concentration of dipyridamole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "penicillin v", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with penicillin v.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "trazodone", "interaction_type": 75, "interaction_text": "The serum concentration of trazodone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Eslicarbazepine acetate", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with Eslicarbazepine acetate.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "prochlorperazine", "interaction_type": 75, "interaction_text": "The serum concentration of prochlorperazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with Atazanavir.", "severity": 2}
{"drug1": "ampicillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "argatroban", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "amikacin", "interaction_type": 75, "interaction_text": "The serum concentration of amikacin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Mirabegron", "interaction_type": 75, "interaction_text": "The serum concentration of Mirabegron can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Paritaprevir", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Paritaprevir.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "praziquantel", "interaction_type": 75, "interaction_text": "The serum concentration of praziquantel can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "betamethasone", "interaction_type": 75, "interaction_text": "The serum concentration of betamethasone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Nedaplatin", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with Nedaplatin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "nafcillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Voxilaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Voxilaprevir can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "norethindrone", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with norethindrone.", "severity": 2}
{"drug1": "ribostamycin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with ribostamycin.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "bromazepam", "interaction_type": 75, "interaction_text": "The serum concentration of bromazepam can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Tiotropium", "interaction_type": 75, "interaction_text": "The serum concentration of Tiotropium can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "benazepril", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "Ecabet", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Ecabet.", "severity": 2}
{"drug1": "phenytoin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clonidine", "interaction_type": 75, "interaction_text": "The serum concentration of clonidine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "SERATRODAST", "interaction_type": 75, "interaction_text": "The serum concentration of SERATRODAST can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Ketobemidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ketobemidone can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Tazobactam", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with Tazobactam.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "flurazepam", "interaction_type": 75, "interaction_text": "The serum concentration of flurazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "argatroban", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "amitriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of amitriptyline can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "orlistat", "drug2": "nitrazepam", "interaction_type": 75, "interaction_text": "The serum concentration of nitrazepam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Lercanidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Lercanidipine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Spectinomycin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with Spectinomycin.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "nevirapine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Glubionate calcium", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Glubionate calcium.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "SAQUINAVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SAQUINAVIR can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "BOPINDOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BOPINDOLOL can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Bosentan", "drug2": "PERHEXILINE", "interaction_type": 75, "interaction_text": "The serum concentration of PERHEXILINE can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Atazanavir", "interaction_type": 75, "interaction_text": "The serum concentration of Atazanavir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "ethanol", "interaction_type": 75, "interaction_text": "The serum concentration of ethanol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vilanterol", "interaction_type": 75, "interaction_text": "The serum concentration of Vilanterol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ivabradine", "interaction_type": 75, "interaction_text": "The serum concentration of Ivabradine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "EFINACONAZOLE", "interaction_type": 75, "interaction_text": "The serum concentration of EFINACONAZOLE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Tavaborole", "interaction_type": 75, "interaction_text": "The serum concentration of Tavaborole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "testosterone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with testosterone.", "severity": 2}
{"drug1": "mitotane", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "triazolam", "interaction_type": 75, "interaction_text": "The serum concentration of triazolam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Netupitant", "interaction_type": 75, "interaction_text": "The serum concentration of Netupitant can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "methoxyflurane", "interaction_type": 75, "interaction_text": "The serum concentration of methoxyflurane can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "dolasetron", "interaction_type": 75, "interaction_text": "The serum concentration of dolasetron can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Dofetilide", "interaction_type": 75, "interaction_text": "The serum concentration of Dofetilide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "citalopram", "interaction_type": 75, "interaction_text": "The serum concentration of citalopram can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "caffeine", "interaction_type": 75, "interaction_text": "The serum concentration of caffeine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "prednisone", "interaction_type": 75, "interaction_text": "The serum concentration of prednisone can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Butoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Butoconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ticlopidine", "interaction_type": 75, "interaction_text": "The serum concentration of ticlopidine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "tetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of tetracycline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "clopidogrel", "interaction_type": 75, "interaction_text": "The serum concentration of clopidogrel can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "l-ascorbic acid", "drug2": "METHAMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of METHAMPHETAMINE can be decreased when it is combined with l-ascorbic acid.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "trandolapril", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "primidone", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "bifonazole", "interaction_type": 75, "interaction_text": "The serum concentration of bifonazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "quinapril", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Retapamulin", "interaction_type": 75, "interaction_text": "The serum concentration of Retapamulin can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Lapatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lapatinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "hyoscyamine", "interaction_type": 75, "interaction_text": "The serum concentration of hyoscyamine can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Retapamulin", "interaction_type": 75, "interaction_text": "The serum concentration of Retapamulin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Efonidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Efonidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "aminophylline", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with aminophylline.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with VERAPAMIL.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "NAPROXEN", "interaction_type": 75, "interaction_text": "The serum concentration of NAPROXEN can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "manidipine", "interaction_type": 75, "interaction_text": "The serum concentration of manidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mefenamic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mefenamic acid can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "felbamate", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Nebivolol", "interaction_type": 75, "interaction_text": "The serum concentration of Nebivolol can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "nafcillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "estradiol", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with estradiol.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "Fosphenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of Fosphenytoin can be decreased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "TAMSULOSIN", "interaction_type": 75, "interaction_text": "The serum concentration of TAMSULOSIN can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "oxiconazole", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with oxiconazole.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "BUPRANOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BUPRANOLOL can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "quinapril", "drug2": "norfloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of norfloxacin can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "proguanil", "interaction_type": 75, "interaction_text": "The serum concentration of proguanil can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "penicillin g", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "carvedilol", "interaction_type": 75, "interaction_text": "The serum concentration of carvedilol can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "epinastine", "drug2": "Cefditoren", "interaction_type": 75, "interaction_text": "The serum concentration of Cefditoren can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "azelastine", "interaction_type": 75, "interaction_text": "The serum concentration of azelastine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Telithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of Telithromycin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Fesoterodine", "interaction_type": 75, "interaction_text": "The serum concentration of Fesoterodine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "nimodipine", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with nimodipine.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "secobarbital", "drug2": "celiprolol", "interaction_type": 75, "interaction_text": "The serum concentration of celiprolol can be decreased when it is combined with secobarbital.", "severity": 2}
{"drug1": "phenytoin", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Fingolimod", "interaction_type": 75, "interaction_text": "The serum concentration of Fingolimod can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Artemether", "interaction_type": 75, "interaction_text": "The serum concentration of Artemether can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Tadalafil", "interaction_type": 75, "interaction_text": "The serum concentration of Tadalafil can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "mitotane", "drug2": "Mirabegron", "interaction_type": 75, "interaction_text": "The serum concentration of Mirabegron can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "carmustine", "interaction_type": 75, "interaction_text": "The serum concentration of carmustine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with ranitidine.", "severity": 2}
{"drug1": "estrone", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with estrone.", "severity": 2}
{"drug1": "calcitriol", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with calcitriol.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "ropinirole", "interaction_type": 75, "interaction_text": "The serum concentration of ropinirole can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "gentamicin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with gentamicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Mirabegron", "interaction_type": 75, "interaction_text": "The serum concentration of Mirabegron can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Enzalutamide", "interaction_type": 75, "interaction_text": "The serum concentration of Enzalutamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "sildenafil", "interaction_type": 75, "interaction_text": "The serum concentration of sildenafil can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Dofetilide", "interaction_type": 75, "interaction_text": "The serum concentration of Dofetilide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "azithromycin", "interaction_type": 75, "interaction_text": "The serum concentration of azithromycin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ticlopidine", "interaction_type": 75, "interaction_text": "The serum concentration of ticlopidine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Ticagrelor", "interaction_type": 75, "interaction_text": "The serum concentration of Ticagrelor can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Lurasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Lurasidone can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "estriol", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with estriol.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Mexiletine", "interaction_type": 75, "interaction_text": "The serum concentration of Mexiletine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Palonosetron", "interaction_type": 75, "interaction_text": "The serum concentration of Palonosetron can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "mirtazapine", "interaction_type": 75, "interaction_text": "The serum concentration of mirtazapine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with METHAMPHETAMINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "RANOLAZINE", "interaction_type": 75, "interaction_text": "The serum concentration of RANOLAZINE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "PONATINIB", "interaction_type": 75, "interaction_text": "The serum concentration of PONATINIB can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "etizolam", "interaction_type": 75, "interaction_text": "The serum concentration of etizolam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "amobarbital", "drug2": "teniposide", "interaction_type": 75, "interaction_text": "The serum concentration of teniposide can be decreased when it is combined with amobarbital.", "severity": 2}
{"drug1": "estradiol", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with estradiol.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 75, "interaction_text": "The serum concentration of ETHYNODIOL DIACETATE can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Isavuconazonium", "interaction_type": 75, "interaction_text": "The serum concentration of Isavuconazonium can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "oxybutynin", "interaction_type": 75, "interaction_text": "The serum concentration of oxybutynin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "amoxicillin", "interaction_type": 75, "interaction_text": "The serum concentration of amoxicillin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Melatonin", "interaction_type": 75, "interaction_text": "The serum concentration of Melatonin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "clonazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clonazepam can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "promethazine", "interaction_type": 75, "interaction_text": "The serum concentration of promethazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "temozolomide", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with temozolomide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "clotiazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clotiazepam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "disopyramide", "interaction_type": 75, "interaction_text": "The serum concentration of disopyramide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "lidocaine", "interaction_type": 75, "interaction_text": "The serum concentration of lidocaine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "DIHYDROCODEINE", "interaction_type": 75, "interaction_text": "The serum concentration of DIHYDROCODEINE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Vilazodone", "interaction_type": 75, "interaction_text": "The serum concentration of Vilazodone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lorcaserin", "interaction_type": 75, "interaction_text": "The serum concentration of Lorcaserin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Darunavir", "interaction_type": 75, "interaction_text": "The serum concentration of Darunavir can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "DESONIDE", "interaction_type": 75, "interaction_text": "The serum concentration of DESONIDE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "argatroban", "drug2": "dyphylline", "interaction_type": 75, "interaction_text": "The serum concentration of dyphylline can be decreased when it is combined with argatroban.", "severity": 2}
{"drug1": "Hexobarbital", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Hexobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "TROLEANDOMYCIN", "interaction_type": 75, "interaction_text": "The serum concentration of TROLEANDOMYCIN can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "dextroamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of dextroamphetamine can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "AMMONIUM CHLORIDE", "drug2": "METHAMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of METHAMPHETAMINE can be decreased when it is combined with AMMONIUM CHLORIDE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ceritinib", "interaction_type": 75, "interaction_text": "The serum concentration of ceritinib can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Brivaracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Brivaracetam can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Spirapril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of BECLOMETHASONE DIPROPIONATE can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "TASOSARTAN", "interaction_type": 75, "interaction_text": "The serum concentration of TASOSARTAN can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nimodipine", "interaction_type": 75, "interaction_text": "The serum concentration of nimodipine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Sorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Sorafenib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "quetiapine", "interaction_type": 75, "interaction_text": "The serum concentration of quetiapine can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "methenamine", "drug2": "hydroxyamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of hydroxyamphetamine can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "Calcium citrate", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Calcium citrate.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "etizolam", "interaction_type": 75, "interaction_text": "The serum concentration of etizolam can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Fesoterodine", "interaction_type": 75, "interaction_text": "The serum concentration of Fesoterodine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "griseofulvin", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with griseofulvin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Strontium ranelate", "interaction_type": 75, "interaction_text": "The serum concentration of Strontium ranelate can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Lumefantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Lumefantrine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Fosamprenavir.", "severity": 2}
{"drug1": "epinastine", "drug2": "Bosutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Bosutinib can be decreased when it is combined with epinastine.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "Amrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Amrubicin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "Pefloxacin", "interaction_type": 75, "interaction_text": "The serum concentration of Pefloxacin can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "ipratropium", "interaction_type": 75, "interaction_text": "The serum concentration of ipratropium can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Gefitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Gefitinib can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Pimecrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Pimecrolimus can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "pyrazinamide", "interaction_type": 75, "interaction_text": "The serum concentration of pyrazinamide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "omeprazole", "interaction_type": 75, "interaction_text": "The serum concentration of omeprazole can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with SAQUINAVIR.", "severity": 2}
{"drug1": "gentamicin", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with gentamicin.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "menadione", "interaction_type": 75, "interaction_text": "The serum concentration of menadione can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "fluvoxamine", "interaction_type": 75, "interaction_text": "The serum concentration of fluvoxamine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with alclometasone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "haloprogin", "interaction_type": 75, "interaction_text": "The serum concentration of haloprogin can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Apixaban", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Apixaban", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Apixaban.", "severity": 2}
{"drug1": "Bexarotene", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Bexarotene.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Clevidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Clevidipine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Tiludronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Tiludronic Acid can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "cimetidine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Perampanel", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Perampanel.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Drospirenone", "interaction_type": 75, "interaction_text": "The serum concentration of Drospirenone can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "kanamycin", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with kanamycin.", "severity": 2}
{"drug1": "Linagliptin", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Linagliptin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Pipotiazine", "interaction_type": 75, "interaction_text": "The serum concentration of Pipotiazine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with pantoprazole.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dasatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Dasatinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "felbamate", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Etoricoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Etoricoxib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "isoniazid", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with isoniazid.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "carbamazepine", "interaction_type": 75, "interaction_text": "The serum concentration of carbamazepine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Rolapitant", "interaction_type": 75, "interaction_text": "The serum concentration of Rolapitant can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "cephalexin", "interaction_type": 75, "interaction_text": "The serum concentration of cephalexin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "nizatidine", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with nizatidine.", "severity": 2}
{"drug1": "primidone", "drug2": "Zuclopenthixol", "interaction_type": 75, "interaction_text": "The serum concentration of Zuclopenthixol can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "itraconazole", "interaction_type": 75, "interaction_text": "The serum concentration of itraconazole can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cilostazol", "interaction_type": 75, "interaction_text": "The serum concentration of cilostazol can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "FERRIC PYROPHOSPHATE", "drug2": "enoxacin", "interaction_type": 75, "interaction_text": "The serum concentration of enoxacin can be decreased when it is combined with FERRIC PYROPHOSPHATE.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "nimesulide", "interaction_type": 75, "interaction_text": "The serum concentration of nimesulide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "simvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of simvastatin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lenvatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lenvatinib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "ampicillin", "drug2": "streptomycin", "interaction_type": 75, "interaction_text": "The serum concentration of streptomycin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "losartan", "interaction_type": 75, "interaction_text": "The serum concentration of losartan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "galanthamine", "interaction_type": 75, "interaction_text": "The serum concentration of galanthamine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "thiopental", "drug2": "griseofulvin", "interaction_type": 75, "interaction_text": "The serum concentration of griseofulvin can be decreased when it is combined with thiopental.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOBETASOL PROPIONATE can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "Ibandronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Ibandronic Acid can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "SULFAMOXOLE", "interaction_type": 75, "interaction_text": "The serum concentration of SULFAMOXOLE can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with fludrocortisone.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "nitrofurantoin", "interaction_type": 75, "interaction_text": "The serum concentration of nitrofurantoin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "primidone", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with prednisone.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "Copanlisib", "interaction_type": 75, "interaction_text": "The serum concentration of Copanlisib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "midazolam", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with midazolam.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "SERATRODAST", "interaction_type": 75, "interaction_text": "The serum concentration of SERATRODAST can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Ketobemidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ketobemidone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "phenoxybenzamine", "interaction_type": 75, "interaction_text": "The serum concentration of phenoxybenzamine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Escitalopram", "interaction_type": 75, "interaction_text": "The serum concentration of Escitalopram can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Trometamol", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Aprepitant", "interaction_type": 75, "interaction_text": "The serum concentration of Aprepitant can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "Bosentan", "drug2": "buprenorphine", "interaction_type": 75, "interaction_text": "The serum concentration of buprenorphine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Lomitapide", "interaction_type": 75, "interaction_text": "The serum concentration of Lomitapide can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Vismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Vismodegib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Quinine", "interaction_type": 75, "interaction_text": "The serum concentration of Quinine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "benzoic acid", "interaction_type": 75, "interaction_text": "The serum concentration of benzoic acid can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with betamethasone.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "netilmicin", "interaction_type": 75, "interaction_text": "The serum concentration of netilmicin can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "acetaminophen", "interaction_type": 75, "interaction_text": "The serum concentration of acetaminophen can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Eletriptan", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with Eletriptan.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Abiraterone", "interaction_type": 75, "interaction_text": "The serum concentration of Abiraterone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "zaleplon", "interaction_type": 75, "interaction_text": "The serum concentration of zaleplon can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "primidone", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "orlistat", "drug2": "Levetiracetam", "interaction_type": 75, "interaction_text": "The serum concentration of Levetiracetam can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "mitotane", "drug2": "Temsirolimus", "interaction_type": 75, "interaction_text": "The serum concentration of Temsirolimus can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with vinblastine.", "severity": 2}
{"drug1": "mitotane", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "metrizamide", "drug2": "deslanoside", "interaction_type": 75, "interaction_text": "The serum concentration of deslanoside can be decreased when it is combined with metrizamide.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Pregabalin", "interaction_type": 75, "interaction_text": "The serum concentration of Pregabalin can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "fexofenadine", "interaction_type": 75, "interaction_text": "The serum concentration of fexofenadine can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "efavirenz", "drug2": "pravastatin", "interaction_type": 75, "interaction_text": "The serum concentration of pravastatin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "Bosentan", "drug2": "fenofibrate", "interaction_type": 75, "interaction_text": "The serum concentration of fenofibrate can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Treprostinil", "interaction_type": 75, "interaction_text": "The serum concentration of Treprostinil can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "phenytoin", "interaction_type": 75, "interaction_text": "The serum concentration of phenytoin can be decreased when it is combined with VALPROIC ACID.", "severity": 2}
{"drug1": "Spirapril", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "Armodafinil", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Armodafinil.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "mitotane", "drug2": "perphenazine", "interaction_type": 75, "interaction_text": "The serum concentration of perphenazine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Ixabepilone", "interaction_type": 75, "interaction_text": "The serum concentration of Ixabepilone can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Enasidenib", "interaction_type": 75, "interaction_text": "The serum concentration of Enasidenib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "dicloxacillin", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with dicloxacillin.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "ADINAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of ADINAZOLAM can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "norgestrel", "interaction_type": 75, "interaction_text": "The serum concentration of norgestrel can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "barnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of barnidipine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "orlistat", "drug2": "Pregabalin", "interaction_type": 75, "interaction_text": "The serum concentration of Pregabalin can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "imipenem", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with imipenem.", "severity": 2}
{"drug1": "phenytoin", "drug2": "flunarizine", "interaction_type": 75, "interaction_text": "The serum concentration of flunarizine can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "trandolapril", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with trandolapril.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Ruxolitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ruxolitinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "reserpine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Cinacalcet", "interaction_type": 75, "interaction_text": "The serum concentration of Cinacalcet can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "cloxacillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with cloxacillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "penicillin g", "drug2": "paromomycin", "interaction_type": 75, "interaction_text": "The serum concentration of paromomycin can be decreased when it is combined with penicillin g.", "severity": 2}
{"drug1": "mitotane", "drug2": "Conivaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Conivaptan can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "ketoprofen", "interaction_type": 75, "interaction_text": "The serum concentration of ketoprofen can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "quinacrine", "interaction_type": 75, "interaction_text": "The serum concentration of quinacrine can be decreased when it is combined with amodiaquine.", "severity": 2}
{"drug1": "Aluminium", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "ribostamycin", "interaction_type": 75, "interaction_text": "The serum concentration of ribostamycin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "orlistat", "drug2": "ergocalciferol", "interaction_type": 75, "interaction_text": "The serum concentration of ergocalciferol can be decreased when it is combined with orlistat.", "severity": 2}
{"drug1": "EDOXABAN", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with EDOXABAN.", "severity": 2}
{"drug1": "Ximelagatran", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Ximelagatran.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "oxiconazole", "interaction_type": 75, "interaction_text": "The serum concentration of oxiconazole can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "nevirapine", "interaction_type": 75, "interaction_text": "The serum concentration of nevirapine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "indinavir", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "Calcium acetate", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Calcium acetate.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "cinnarizine", "interaction_type": 75, "interaction_text": "The serum concentration of cinnarizine can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Cobicistat", "interaction_type": 75, "interaction_text": "The serum concentration of Cobicistat can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "UMECLIDINIUM", "interaction_type": 75, "interaction_text": "The serum concentration of UMECLIDINIUM can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Lenvatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Lenvatinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Nintedanib", "interaction_type": 75, "interaction_text": "The serum concentration of Nintedanib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "methicillin", "drug2": "Valrubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Valrubicin can be decreased when it is combined with methicillin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "celecoxib", "interaction_type": 75, "interaction_text": "The serum concentration of celecoxib can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "raloxifene", "interaction_type": 75, "interaction_text": "The serum concentration of raloxifene can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Sevelamer", "drug2": "tacrolimus", "interaction_type": 75, "interaction_text": "The serum concentration of tacrolimus can be decreased when it is combined with Sevelamer.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "bezafibrate", "interaction_type": 75, "interaction_text": "The serum concentration of bezafibrate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "digitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of digitoxin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "colchicine", "interaction_type": 75, "interaction_text": "The serum concentration of colchicine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "oxycodone", "interaction_type": 75, "interaction_text": "The serum concentration of oxycodone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "buspirone", "interaction_type": 75, "interaction_text": "The serum concentration of buspirone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "methyldopa", "interaction_type": 75, "interaction_text": "The serum concentration of methyldopa can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Daclatasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Daclatasvir can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "doxepin", "interaction_type": 75, "interaction_text": "The serum concentration of doxepin can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "fosinopril", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "osimertinib", "drug2": "nitric oxide", "interaction_type": 75, "interaction_text": "The serum concentration of nitric oxide can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "captopril", "interaction_type": 75, "interaction_text": "The serum concentration of captopril can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "MEZLOCILLIN", "drug2": "metrizamide", "interaction_type": 75, "interaction_text": "The serum concentration of metrizamide can be decreased when it is combined with MEZLOCILLIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "IMIQUIMOD", "interaction_type": 75, "interaction_text": "The serum concentration of IMIQUIMOD can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "trimipramine", "interaction_type": 75, "interaction_text": "The serum concentration of trimipramine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "amiodarone", "interaction_type": 75, "interaction_text": "The serum concentration of amiodarone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "MAGNESIUM SULFATE", "drug2": "ROSOXACIN", "interaction_type": 75, "interaction_text": "The serum concentration of ROSOXACIN can be decreased when it is combined with MAGNESIUM SULFATE.", "severity": 2}
{"drug1": "dexlansoprazole", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with dexlansoprazole.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "demeclocycline", "interaction_type": 75, "interaction_text": "The serum concentration of demeclocycline can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "mitotane", "drug2": "pilocarpine", "interaction_type": 75, "interaction_text": "The serum concentration of pilocarpine can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "phenytoin", "drug2": "fluvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of fluvastatin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "phenytoin", "drug2": "Rosuvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Rosuvastatin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Neratinib", "interaction_type": 75, "interaction_text": "The serum concentration of Neratinib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Ospemifene", "interaction_type": 75, "interaction_text": "The serum concentration of Ospemifene can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with Asenapine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Permethrin", "interaction_type": 75, "interaction_text": "The serum concentration of Permethrin can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "methenamine", "drug2": "METHAMPHETAMINE", "interaction_type": 75, "interaction_text": "The serum concentration of METHAMPHETAMINE can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "methenamine", "drug2": "dextroamphetamine", "interaction_type": 75, "interaction_text": "The serum concentration of dextroamphetamine can be decreased when it is combined with methenamine.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "flurandrenolide", "interaction_type": 75, "interaction_text": "The serum concentration of flurandrenolide can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with ritonavir.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with cimetidine.", "severity": 2}
{"drug1": "Sucralfate", "drug2": "fleroxacin", "interaction_type": 75, "interaction_text": "The serum concentration of fleroxacin can be decreased when it is combined with Sucralfate.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "methadone", "interaction_type": 75, "interaction_text": "The serum concentration of methadone can be decreased when it is combined with nelfinavir.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "primidone", "drug2": "equilin", "interaction_type": 75, "interaction_text": "The serum concentration of equilin can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "fluocinonide", "interaction_type": 75, "interaction_text": "The serum concentration of fluocinonide can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Bendamustine", "interaction_type": 75, "interaction_text": "The serum concentration of Bendamustine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "mifepristone", "interaction_type": 75, "interaction_text": "The serum concentration of mifepristone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Axitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Axitinib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Ziprasidone", "interaction_type": 75, "interaction_text": "The serum concentration of Ziprasidone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with fluvastatin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with daunorubicin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with amiodarone.", "severity": 2}
{"drug1": "ROSOXACIN", "drug2": "didanosine", "interaction_type": 75, "interaction_text": "The serum concentration of didanosine can be decreased when it is combined with ROSOXACIN.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "zolpidem", "interaction_type": 75, "interaction_text": "The serum concentration of zolpidem can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "HYDROCODONE", "interaction_type": 75, "interaction_text": "The serum concentration of HYDROCODONE can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "lovastatin", "interaction_type": 75, "interaction_text": "The serum concentration of lovastatin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Vorapaxar", "interaction_type": 75, "interaction_text": "The serum concentration of Vorapaxar can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Suvorexant", "interaction_type": 75, "interaction_text": "The serum concentration of Suvorexant can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ELIGLUSTAT", "interaction_type": 75, "interaction_text": "The serum concentration of ELIGLUSTAT can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "phenytoin", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "felodipine", "interaction_type": 75, "interaction_text": "The serum concentration of felodipine can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "phenytoin", "drug2": "loteprednol", "interaction_type": 75, "interaction_text": "The serum concentration of loteprednol can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "PENICILLIN G PROCAINE", "drug2": "streptozocin", "interaction_type": 75, "interaction_text": "The serum concentration of streptozocin can be decreased when it is combined with PENICILLIN G PROCAINE.", "severity": 2}
{"drug1": "Trometamol", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with Trometamol.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "RIMEXOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of RIMEXOLONE can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Pefloxacin", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with Pefloxacin.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Fluprednidene", "interaction_type": 75, "interaction_text": "The serum concentration of Fluprednidene can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "FLUOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUOCORTOLONE can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "felbamate", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with felbamate.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "OXCARBAZEPINE", "drug2": "Ulipristal", "interaction_type": 75, "interaction_text": "The serum concentration of Ulipristal can be decreased when it is combined with OXCARBAZEPINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Venetoclax", "interaction_type": 75, "interaction_text": "The serum concentration of Venetoclax can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "sulfadiazine", "interaction_type": 75, "interaction_text": "The serum concentration of sulfadiazine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "mefloquine", "interaction_type": 75, "interaction_text": "The serum concentration of mefloquine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "cisapride", "interaction_type": 75, "interaction_text": "The serum concentration of cisapride can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "IVERMECTIN", "interaction_type": 75, "interaction_text": "The serum concentration of IVERMECTIN can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "chloroquine", "interaction_type": 75, "interaction_text": "The serum concentration of chloroquine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "temozolomide", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with temozolomide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dronedarone", "interaction_type": 75, "interaction_text": "The serum concentration of Dronedarone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bivalirudin", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Bivalirudin.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "Nilotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Nilotinib can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with gemfibrozil.", "severity": 2}
{"drug1": "fosinopril", "drug2": "aminophylline", "interaction_type": 75, "interaction_text": "The serum concentration of aminophylline can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "primidone", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "phenytoin", "drug2": "metronidazole", "interaction_type": 75, "interaction_text": "The serum concentration of metronidazole can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "sotalol", "interaction_type": 75, "interaction_text": "The serum concentration of sotalol can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "fludrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of fludrocortisone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "cyclosporin A", "interaction_type": 75, "interaction_text": "The serum concentration of cyclosporin A can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Linagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Linagliptin can be decreased when it is combined with reserpine.", "severity": 2}
{"drug1": "Prucalopride", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with Prucalopride.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "phenoxybenzamine", "interaction_type": 75, "interaction_text": "The serum concentration of phenoxybenzamine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "Lumiracoxib", "interaction_type": 75, "interaction_text": "The serum concentration of Lumiracoxib can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "SERATRODAST", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with SERATRODAST.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "nalidixic acid", "interaction_type": 75, "interaction_text": "The serum concentration of nalidixic acid can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "Magnesium salicylate", "drug2": "Dipotassium hydrogen phosphate", "interaction_type": 75, "interaction_text": "The serum concentration of Dipotassium hydrogen phosphate can be decreased when it is combined with Magnesium salicylate.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ropinirole", "interaction_type": 75, "interaction_text": "The serum concentration of ropinirole can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "liothyronine", "interaction_type": 75, "interaction_text": "The serum concentration of liothyronine can be decreased when it is combined with ciprofloxacin.", "severity": 2}
{"drug1": "ethanol", "drug2": "warfarin", "interaction_type": 75, "interaction_text": "The serum concentration of warfarin can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "Calcium phosphate", "drug2": "Risedronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Risedronic acid can be decreased when it is combined with Calcium phosphate.", "severity": 2}
{"drug1": "nevirapine", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "CALCIUM CHLORIDE", "drug2": "chlortetracycline", "interaction_type": 75, "interaction_text": "The serum concentration of chlortetracycline can be decreased when it is combined with CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "daunorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of daunorubicin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Rotigotine", "interaction_type": 75, "interaction_text": "The serum concentration of Rotigotine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Indacaterol", "interaction_type": 75, "interaction_text": "The serum concentration of Indacaterol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "folinic acid", "drug2": "phenobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of phenobarbital can be decreased when it is combined with folinic acid.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Posaconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Posaconazole can be decreased when it is combined with metoclopramide.", "severity": 2}
{"drug1": "nevirapine", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "nevirapine", "drug2": "desoximetasone", "interaction_type": 75, "interaction_text": "The serum concentration of desoximetasone can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Oritavancin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Oritavancin.", "severity": 2}
{"drug1": "benazepril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with benazepril.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dienogest", "interaction_type": 75, "interaction_text": "The serum concentration of Dienogest can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with PERINDOPRIL.", "severity": 2}
{"drug1": "mitotane", "drug2": "estazolam", "interaction_type": 75, "interaction_text": "The serum concentration of estazolam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Flucloxacillin", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with Flucloxacillin.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with doxorubicin.", "severity": 2}
{"drug1": "Aluminium", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "oxamniquine", "interaction_type": 75, "interaction_text": "The serum concentration of oxamniquine can be decreased when it is combined with PRIMAQUINE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "sulfadiazine", "interaction_type": 75, "interaction_text": "The serum concentration of sulfadiazine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "mefloquine", "interaction_type": 75, "interaction_text": "The serum concentration of mefloquine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Delafloxacin", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Delafloxacin.", "severity": 2}
{"drug1": "Clevidipine", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Clevidipine.", "severity": 2}
{"drug1": "piperacillin", "drug2": "tobramycin", "interaction_type": 75, "interaction_text": "The serum concentration of tobramycin can be decreased when it is combined with piperacillin.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "chlorzoxazone", "interaction_type": 75, "interaction_text": "The serum concentration of chlorzoxazone can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "Roflumilast", "interaction_type": 75, "interaction_text": "The serum concentration of Roflumilast can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "guanabenz", "interaction_type": 75, "interaction_text": "The serum concentration of guanabenz can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with SIMEPREVIR.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Asenapine", "interaction_type": 75, "interaction_text": "The serum concentration of Asenapine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "nevirapine", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Eltrombopag", "interaction_type": 75, "interaction_text": "The serum concentration of Eltrombopag can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "indinavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with indinavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Tolvaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Tolvaptan can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "ALENDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of ALENDRONIC ACID can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "etoposide", "interaction_type": 75, "interaction_text": "The serum concentration of etoposide can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with olanzapine.", "severity": 2}
{"drug1": "Liotrix", "drug2": "Afatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Afatinib can be decreased when it is combined with Liotrix.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Repaglinide", "interaction_type": 75, "interaction_text": "The serum concentration of Repaglinide can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "doxorubicin", "interaction_type": 75, "interaction_text": "The serum concentration of doxorubicin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Hexobarbital", "interaction_type": 75, "interaction_text": "The serum concentration of Hexobarbital can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Penicillin G benzathine", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with Penicillin G benzathine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Medroxyprogesterone acetate", "interaction_type": 75, "interaction_text": "The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Telaprevir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Arformoterol", "interaction_type": 75, "interaction_text": "The serum concentration of Arformoterol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "mitotane", "drug2": "dantrolene", "interaction_type": 75, "interaction_text": "The serum concentration of dantrolene can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ADINAZOLAM", "interaction_type": 75, "interaction_text": "The serum concentration of ADINAZOLAM can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "norethindrone", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with norethindrone.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "nortriptyline", "interaction_type": 75, "interaction_text": "The serum concentration of nortriptyline can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "Retigabine", "interaction_type": 75, "interaction_text": "The serum concentration of Retigabine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "methylprednisolone", "interaction_type": 75, "interaction_text": "The serum concentration of methylprednisolone can be decreased when it is combined with pentobarbital.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "zafirlukast", "interaction_type": 75, "interaction_text": "The serum concentration of zafirlukast can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "phenytoin", "drug2": "PREDNICARBATE", "interaction_type": 75, "interaction_text": "The serum concentration of PREDNICARBATE can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Ribociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Ribociclib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Maraviroc", "interaction_type": 75, "interaction_text": "The serum concentration of Maraviroc can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "CARTEOLOL", "interaction_type": 75, "interaction_text": "The serum concentration of CARTEOLOL can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "mifepristone", "interaction_type": 75, "interaction_text": "The serum concentration of mifepristone can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "pergolide", "interaction_type": 75, "interaction_text": "The serum concentration of pergolide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "deferiprone", "interaction_type": 75, "interaction_text": "The serum concentration of deferiprone can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "naloxone", "interaction_type": 75, "interaction_text": "The serum concentration of naloxone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "propafenone", "interaction_type": 75, "interaction_text": "The serum concentration of propafenone can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ifosfamide", "interaction_type": 75, "interaction_text": "The serum concentration of ifosfamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Palonosetron", "interaction_type": 75, "interaction_text": "The serum concentration of Palonosetron can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "azlocillin", "drug2": "gentamicin", "interaction_type": 75, "interaction_text": "The serum concentration of gentamicin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "VORTIOXETINE", "interaction_type": 75, "interaction_text": "The serum concentration of VORTIOXETINE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "xylometazoline", "interaction_type": 75, "interaction_text": "The serum concentration of xylometazoline can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "chloroquine", "drug2": "hexylresorcinol", "interaction_type": 75, "interaction_text": "The serum concentration of hexylresorcinol can be decreased when it is combined with chloroquine.", "severity": 2}
{"drug1": "mitotane", "drug2": "cannabidiol", "interaction_type": 75, "interaction_text": "The serum concentration of cannabidiol can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "ceritinib", "interaction_type": 75, "interaction_text": "The serum concentration of ceritinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Imatinib", "interaction_type": 75, "interaction_text": "The serum concentration of Imatinib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Aprepitant", "drug2": "ethinyl estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of ethinyl estradiol can be decreased when it is combined with Aprepitant.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Vitamin D3", "interaction_type": 75, "interaction_text": "The serum concentration of Vitamin D3 can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "mitotane", "drug2": "BISOPROLOL", "interaction_type": 75, "interaction_text": "The serum concentration of BISOPROLOL can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "RIFABUTIN", "interaction_type": 75, "interaction_text": "The serum concentration of RIFABUTIN can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "PARAMETHADIONE", "interaction_type": 75, "interaction_text": "The serum concentration of PARAMETHADIONE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "ampicillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with ampicillin.", "severity": 2}
{"drug1": "Almasilate", "drug2": "Clodronic Acid", "interaction_type": 75, "interaction_text": "The serum concentration of Clodronic Acid can be decreased when it is combined with Almasilate.", "severity": 2}
{"drug1": "Magnesium trisilicate", "drug2": "Pitavastatin", "interaction_type": 75, "interaction_text": "The serum concentration of Pitavastatin can be decreased when it is combined with Magnesium trisilicate.", "severity": 2}
{"drug1": "Aluminium", "drug2": "Ledipasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Ledipasvir can be decreased when it is combined with Aluminium.", "severity": 2}
{"drug1": "mycophenolic acid", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with mycophenolic acid.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "flumethasone", "interaction_type": 75, "interaction_text": "The serum concentration of flumethasone can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "FERRIC CITRATE", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with FERRIC CITRATE.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with rabeprazole.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "chloramphenicol", "interaction_type": 75, "interaction_text": "The serum concentration of chloramphenicol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "OXTRIPHYLLINE", "interaction_type": 75, "interaction_text": "The serum concentration of OXTRIPHYLLINE can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "dienestrol", "interaction_type": 75, "interaction_text": "The serum concentration of dienestrol can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "ETONOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of ETONOGESTREL can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "morphine", "interaction_type": 75, "interaction_text": "The serum concentration of morphine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Ropivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Ropivacaine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "bupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of bupivacaine can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Abemaciclib", "interaction_type": 75, "interaction_text": "The serum concentration of Abemaciclib can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ritonavir", "interaction_type": 75, "interaction_text": "The serum concentration of ritonavir can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Aliskiren", "drug2": "furosemide", "interaction_type": 75, "interaction_text": "The serum concentration of furosemide can be decreased when it is combined with Aliskiren.", "severity": 2}
{"drug1": "vinblastine", "drug2": "SOFOSBUVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SOFOSBUVIR can be decreased when it is combined with vinblastine.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "estrone", "interaction_type": 75, "interaction_text": "The serum concentration of estrone can be decreased when it is combined with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Imidafenacin", "interaction_type": 75, "interaction_text": "The serum concentration of Imidafenacin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Elbasvir", "interaction_type": 75, "interaction_text": "The serum concentration of Elbasvir can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "SIMEPREVIR", "interaction_type": 75, "interaction_text": "The serum concentration of SIMEPREVIR can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "nisoldipine", "interaction_type": 75, "interaction_text": "The serum concentration of nisoldipine can be decreased when it is combined with carbamazepine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "GUANFACINE", "interaction_type": 75, "interaction_text": "The serum concentration of GUANFACINE can be decreased when it is combined with RIFAPENTINE.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Regorafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Regorafenib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Tofacitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Tofacitinib can be decreased when it is combined with nevirapine.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "ethanol", "interaction_type": 75, "interaction_text": "The serum concentration of ethanol can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Saxagliptin", "interaction_type": 75, "interaction_text": "The serum concentration of Saxagliptin can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "nafcillin", "drug2": "Spectinomycin", "interaction_type": 75, "interaction_text": "The serum concentration of Spectinomycin can be decreased when it is combined with nafcillin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Dabrafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Dabrafenib can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "Delavirdine", "interaction_type": 75, "interaction_text": "The serum concentration of Delavirdine can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "Saxagliptin", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Saxagliptin.", "severity": 2}
{"drug1": "mitotane", "drug2": "Levomilnacipran", "interaction_type": 75, "interaction_text": "The serum concentration of Levomilnacipran can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Panobinostat", "interaction_type": 75, "interaction_text": "The serum concentration of Panobinostat can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "Benidipine", "interaction_type": 75, "interaction_text": "The serum concentration of Benidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Rifaximin", "drug2": "cilnidipine", "interaction_type": 75, "interaction_text": "The serum concentration of cilnidipine can be decreased when it is combined with Rifaximin.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "mianserin", "interaction_type": 75, "interaction_text": "The serum concentration of mianserin can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Apixaban", "interaction_type": 75, "interaction_text": "The serum concentration of Apixaban can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "plicamycin", "interaction_type": 75, "interaction_text": "The serum concentration of plicamycin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "vincristine", "interaction_type": 75, "interaction_text": "The serum concentration of vincristine can be decreased when it is combined with cyclosporin A.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "Levobupivacaine", "interaction_type": 75, "interaction_text": "The serum concentration of Levobupivacaine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Enasidenib", "interaction_type": 75, "interaction_text": "The serum concentration of Enasidenib can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Clobetasone", "interaction_type": 75, "interaction_text": "The serum concentration of Clobetasone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "efavirenz", "drug2": "gabapentin", "interaction_type": 75, "interaction_text": "The serum concentration of gabapentin can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "CALCIUM GLUCONATE", "drug2": "Zoledronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Zoledronic acid can be decreased when it is combined with CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "chenodeoxycholic acid", "interaction_type": 75, "interaction_text": "The serum concentration of chenodeoxycholic acid can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "CLOCORTOLONE", "interaction_type": 75, "interaction_text": "The serum concentration of CLOCORTOLONE can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "CABAZITAXEL", "interaction_type": 75, "interaction_text": "The serum concentration of CABAZITAXEL can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "benzyl alcohol", "interaction_type": 75, "interaction_text": "The serum concentration of benzyl alcohol can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Naloxegol", "interaction_type": 75, "interaction_text": "The serum concentration of Naloxegol can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "loperamide", "interaction_type": 75, "interaction_text": "The serum concentration of loperamide can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "theophylline", "interaction_type": 75, "interaction_text": "The serum concentration of theophylline can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "efavirenz", "interaction_type": 75, "interaction_text": "The serum concentration of efavirenz can be decreased when it is combined with phenytoin.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "abacavir", "interaction_type": 75, "interaction_text": "The serum concentration of abacavir can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Levomilnacipran", "interaction_type": 75, "interaction_text": "The serum concentration of Levomilnacipran can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Pomalidomide", "interaction_type": 75, "interaction_text": "The serum concentration of Pomalidomide can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "quinapril", "drug2": "minocycline", "interaction_type": 75, "interaction_text": "The serum concentration of minocycline can be decreased when it is combined with quinapril.", "severity": 2}
{"drug1": "fosinopril", "drug2": "estradiol", "interaction_type": 75, "interaction_text": "The serum concentration of estradiol can be decreased when it is combined with fosinopril.", "severity": 2}
{"drug1": "metrizamide", "drug2": "ouabain", "interaction_type": 75, "interaction_text": "The serum concentration of ouabain can be decreased when it is combined with metrizamide.", "severity": 2}
{"drug1": "Fosaprepitant", "drug2": "DESOGESTREL", "interaction_type": 75, "interaction_text": "The serum concentration of DESOGESTREL can be decreased when it is combined with Fosaprepitant.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "clozapine", "interaction_type": 75, "interaction_text": "The serum concentration of clozapine can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Telaprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Telaprevir can be decreased when it is combined with Fluticasone furoate.", "severity": 2}
{"drug1": "Teriflunomide", "drug2": "propofol", "interaction_type": 75, "interaction_text": "The serum concentration of propofol can be decreased when it is combined with Teriflunomide.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "GESTODENE", "interaction_type": 75, "interaction_text": "The serum concentration of GESTODENE can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Mephobarbital", "drug2": "doxycycline", "interaction_type": 75, "interaction_text": "The serum concentration of doxycycline can be decreased when it is combined with Mephobarbital.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "cephalexin", "interaction_type": 75, "interaction_text": "The serum concentration of cephalexin can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ambroxol", "interaction_type": 75, "interaction_text": "The serum concentration of ambroxol can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "efavirenz", "drug2": "ATOVAQUONE", "interaction_type": 75, "interaction_text": "The serum concentration of ATOVAQUONE can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "efavirenz", "drug2": "nifedipine", "interaction_type": 75, "interaction_text": "The serum concentration of nifedipine can be decreased when it is combined with efavirenz.", "severity": 2}
{"drug1": "MAGNESIUM HYDROXIDE", "drug2": "Pazopanib", "interaction_type": 75, "interaction_text": "The serum concentration of Pazopanib can be decreased when it is combined with MAGNESIUM HYDROXIDE.", "severity": 2}
{"drug1": "Magaldrate", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Magaldrate.", "severity": 2}
{"drug1": "budesonide", "drug2": "isoniazid", "interaction_type": 75, "interaction_text": "The serum concentration of isoniazid can be decreased when it is combined with budesonide.", "severity": 2}
{"drug1": "Delafloxacin", "drug2": "Vemurafenib", "interaction_type": 75, "interaction_text": "The serum concentration of Vemurafenib can be decreased when it is combined with Delafloxacin.", "severity": 2}
{"drug1": "Bosentan", "drug2": "cyclobenzaprine", "interaction_type": 75, "interaction_text": "The serum concentration of cyclobenzaprine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "azlocillin", "drug2": "kanamycin", "interaction_type": 75, "interaction_text": "The serum concentration of kanamycin can be decreased when it is combined with azlocillin.", "severity": 2}
{"drug1": "SODIUM BICARBONATE", "drug2": "Dabigatran etexilate", "interaction_type": 75, "interaction_text": "The serum concentration of Dabigatran etexilate can be decreased when it is combined with SODIUM BICARBONATE.", "severity": 2}
{"drug1": "Pivmecillinam", "drug2": "Epirubicin", "interaction_type": 75, "interaction_text": "The serum concentration of Epirubicin can be decreased when it is combined with Pivmecillinam.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "promethazine", "interaction_type": 75, "interaction_text": "The serum concentration of promethazine can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Bosentan", "drug2": "tolterodine", "interaction_type": 75, "interaction_text": "The serum concentration of tolterodine can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Bosentan", "drug2": "selegiline", "interaction_type": 75, "interaction_text": "The serum concentration of selegiline can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "TICARCILLIN", "drug2": "Arbekacin", "interaction_type": 75, "interaction_text": "The serum concentration of Arbekacin can be decreased when it is combined with TICARCILLIN.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "amoxicillin", "interaction_type": 75, "interaction_text": "The serum concentration of amoxicillin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Melatonin", "interaction_type": 75, "interaction_text": "The serum concentration of Melatonin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "ethanol", "drug2": "ACENOCOUMAROL", "interaction_type": 75, "interaction_text": "The serum concentration of ACENOCOUMAROL can be decreased when it is combined with ethanol.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "CEFPODOXIME", "interaction_type": 75, "interaction_text": "The serum concentration of CEFPODOXIME can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "medrysone", "interaction_type": 75, "interaction_text": "The serum concentration of medrysone can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "norethindrone", "interaction_type": 75, "interaction_text": "The serum concentration of norethindrone can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "diethylstilbestrol", "interaction_type": 75, "interaction_text": "The serum concentration of diethylstilbestrol can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "atorvastatin", "interaction_type": 75, "interaction_text": "The serum concentration of atorvastatin can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Etidronic acid", "interaction_type": 75, "interaction_text": "The serum concentration of Etidronic acid can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Lopinavir.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Macitentan", "interaction_type": 75, "interaction_text": "The serum concentration of Macitentan can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Tiotropium", "interaction_type": 75, "interaction_text": "The serum concentration of Tiotropium can be decreased when it is combined with Enzalutamide.", "severity": 2}
{"drug1": "Darunavir", "drug2": "zidovudine", "interaction_type": 75, "interaction_text": "The serum concentration of zidovudine can be decreased when it is combined with Darunavir.", "severity": 2}
{"drug1": "topotecan", "drug2": "Aripiprazole", "interaction_type": 75, "interaction_text": "The serum concentration of Aripiprazole can be decreased when it is combined with topotecan.", "severity": 2}
{"drug1": "mitotane", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "hexylresorcinol", "interaction_type": 75, "interaction_text": "The serum concentration of hexylresorcinol can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "mitotane", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 75, "interaction_text": "The serum concentration of FLUTICASONE PROPIONATE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "LISURIDE", "interaction_type": 75, "interaction_text": "The serum concentration of LISURIDE can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "Voriconazole", "interaction_type": 75, "interaction_text": "The serum concentration of Voriconazole can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "enalapril", "interaction_type": 75, "interaction_text": "The serum concentration of enalapril can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "mitotane", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "CALCIUM CARBONATE", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with CALCIUM CARBONATE.", "severity": 2}
{"drug1": "Iron sucrose", "drug2": "PAMIDRONIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of PAMIDRONIC ACID can be decreased when it is combined with Iron sucrose.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "glucosamine", "interaction_type": 75, "interaction_text": "The serum concentration of glucosamine can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "enalapril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with enalapril.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "losartan", "interaction_type": 75, "interaction_text": "The serum concentration of losartan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Halofantrine", "interaction_type": 75, "interaction_text": "The serum concentration of Halofantrine can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "dantrolene", "interaction_type": 75, "interaction_text": "The serum concentration of dantrolene can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "estazolam", "interaction_type": 75, "interaction_text": "The serum concentration of estazolam can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "finasteride", "interaction_type": 75, "interaction_text": "The serum concentration of finasteride can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Sunitinib", "interaction_type": 75, "interaction_text": "The serum concentration of Sunitinib can be decreased when it is combined with dexamethasone.", "severity": 2}
{"drug1": "famotidine", "drug2": "Rilpivirine", "interaction_type": 75, "interaction_text": "The serum concentration of Rilpivirine can be decreased when it is combined with famotidine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "irinotecan", "interaction_type": 75, "interaction_text": "The serum concentration of irinotecan can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Mometasone", "interaction_type": 75, "interaction_text": "The serum concentration of Mometasone can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Coenzyme Q10", "interaction_type": 75, "interaction_text": "The serum concentration of Coenzyme Q10 can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "Bortezomib", "interaction_type": 75, "interaction_text": "The serum concentration of Bortezomib can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "mitotane", "drug2": "clonazepam", "interaction_type": 75, "interaction_text": "The serum concentration of clonazepam can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Lomitapide", "interaction_type": 75, "interaction_text": "The serum concentration of Lomitapide can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "kanamycin", "drug2": "acetyldigitoxin", "interaction_type": 75, "interaction_text": "The serum concentration of acetyldigitoxin can be decreased when it is combined with kanamycin.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "estramustine", "interaction_type": 75, "interaction_text": "The serum concentration of estramustine can be decreased when it is combined with Elvitegravir.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Canagliflozin", "interaction_type": 75, "interaction_text": "The serum concentration of Canagliflozin can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Fluticasone furoate", "interaction_type": 75, "interaction_text": "The serum concentration of Fluticasone furoate can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "formestane", "interaction_type": 75, "interaction_text": "The serum concentration of formestane can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Bedaquiline", "interaction_type": 75, "interaction_text": "The serum concentration of Bedaquiline can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "Trabectedin", "interaction_type": 75, "interaction_text": "The serum concentration of Trabectedin can be decreased when it is combined with RIFABUTIN.", "severity": 2}
{"drug1": "Bosentan", "drug2": "hydrocortisone", "interaction_type": 75, "interaction_text": "The serum concentration of hydrocortisone can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Cobicistat.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "mycophenolic acid", "interaction_type": 75, "interaction_text": "The serum concentration of mycophenolic acid can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Vemurafenib", "drug2": "Safinamide", "interaction_type": 75, "interaction_text": "The serum concentration of Safinamide can be decreased when it is combined with Vemurafenib.", "severity": 2}
{"drug1": "MAGNESIUM OXIDE", "drug2": "ketoconazole", "interaction_type": 75, "interaction_text": "The serum concentration of ketoconazole can be decreased when it is combined with MAGNESIUM OXIDE.", "severity": 2}
{"drug1": "Bosentan", "drug2": "ZILEUTON", "interaction_type": 75, "interaction_text": "The serum concentration of ZILEUTON can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "galanthamine", "interaction_type": 75, "interaction_text": "The serum concentration of galanthamine can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "tamoxifen", "interaction_type": 75, "interaction_text": "The serum concentration of tamoxifen can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "diclofenac", "interaction_type": 75, "interaction_text": "The serum concentration of diclofenac can be decreased when it is combined with Rifampicin.", "severity": 2}
{"drug1": "Esomeprazole", "drug2": "Erlotinib", "interaction_type": 75, "interaction_text": "The serum concentration of Erlotinib can be decreased when it is combined with Esomeprazole.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "busulfan", "interaction_type": 75, "interaction_text": "The serum concentration of busulfan can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "osimertinib", "drug2": "leflunomide", "interaction_type": 75, "interaction_text": "The serum concentration of leflunomide can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "osimertinib", "drug2": "hesperetin", "interaction_type": 75, "interaction_text": "The serum concentration of hesperetin can be decreased when it is combined with osimertinib.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Ibrutinib", "interaction_type": 75, "interaction_text": "The serum concentration of Ibrutinib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Deferasirox", "drug2": "letrozole", "interaction_type": 75, "interaction_text": "The serum concentration of letrozole can be decreased when it is combined with Deferasirox.", "severity": 2}
{"drug1": "primidone", "drug2": "Cabozantinib", "interaction_type": 75, "interaction_text": "The serum concentration of Cabozantinib can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "primidone", "drug2": "Boceprevir", "interaction_type": 75, "interaction_text": "The serum concentration of Boceprevir can be decreased when it is combined with primidone.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Idelalisib", "interaction_type": 75, "interaction_text": "The serum concentration of Idelalisib can be decreased when it is combined with Lumacaftor.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "Conivaptan", "interaction_type": 75, "interaction_text": "The serum concentration of Conivaptan can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Brigatinib", "drug2": "rapamycin", "interaction_type": 75, "interaction_text": "The serum concentration of rapamycin can be decreased when it is combined with Brigatinib.", "severity": 2}
{"drug1": "Cilastatin", "drug2": "mestranol", "interaction_type": 75, "interaction_text": "The serum concentration of mestranol can be decreased when it is combined with Cilastatin.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "oxiconazole", "interaction_type": 75, "interaction_text": "The serum concentration of oxiconazole can be decreased when it is combined with Fosphenytoin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Fosamprenavir", "interaction_type": 75, "interaction_text": "The serum concentration of Fosamprenavir can be decreased when it is combined with Boceprevir.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "L-thyroxine", "interaction_type": 75, "interaction_text": "The serum concentration of L-thyroxine can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Bosentan", "drug2": "Vismodegib", "interaction_type": 75, "interaction_text": "The serum concentration of Vismodegib can be decreased when it is combined with Bosentan.", "severity": 2}
{"drug1": "mitotane", "drug2": "glipizide", "interaction_type": 75, "interaction_text": "The serum concentration of glipizide can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "Flubendazole", "interaction_type": 75, "interaction_text": "The serum concentration of Flubendazole can be decreased when it is combined with hydroxychloroquine.", "severity": 2}
{"drug1": "mitotane", "drug2": "oxybutynin", "interaction_type": 75, "interaction_text": "The serum concentration of oxybutynin can be decreased when it is combined with mitotane.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "quinidine", "interaction_type": 75, "interaction_text": "The serum concentration of quinidine can be decreased when it is combined with nisoldipine.", "severity": 2}
{"drug1": "Dabrafenib", "drug2": "Vitamin D3", "interaction_type": 75, "interaction_text": "The serum concentration of Vitamin D3 can be decreased when it is combined with Dabrafenib.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Riociguat", "interaction_type": 75, "interaction_text": "The serum concentration of Riociguat can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Aluminium hydroxide", "drug2": "Dolutegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Dolutegravir can be decreased when it is combined with Aluminium hydroxide.", "severity": 2}
{"drug1": "Asunaprevir", "drug2": "VALPROIC ACID", "interaction_type": 75, "interaction_text": "The serum concentration of VALPROIC ACID can be decreased when it is combined with Asunaprevir.", "severity": 2}
{"drug1": "Bismuth subcitrate potassium", "drug2": "Elvitegravir", "interaction_type": 75, "interaction_text": "The serum concentration of Elvitegravir can be decreased when it is combined with Bismuth subcitrate potassium.", "severity": 2}
{"drug1": "Spirapril", "drug2": "Estrone sulfate", "interaction_type": 75, "interaction_text": "The serum concentration of Estrone sulfate can be decreased when it is combined with Spirapril.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Nintedanib", "interaction_type": 75, "interaction_text": "The serum concentration of Nintedanib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Palbociclib", "interaction_type": 75, "interaction_text": "The serum concentration of Palbociclib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Tasimelteon", "interaction_type": 75, "interaction_text": "The serum concentration of Tasimelteon can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "Olaparib", "interaction_type": 75, "interaction_text": "The serum concentration of Olaparib can be decreased when it is combined with phenobarbital.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "mirtazapine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of mirtazapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "diphenhydramine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of diphenhydramine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "clemastine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of clemastine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "cimetidine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of cimetidine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "mirtazapine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of mirtazapine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "clemastine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of clemastine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "mianserin", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of mianserin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "flumazenil", "drug2": "zolpidem", "interaction_type": 76, "interaction_text": "flumazenil may decrease the sedative activities of zolpidem.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "doxepin", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of doxepin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "doxepin", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of doxepin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "mianserin", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of mianserin.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "doxepin", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of doxepin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "flumazenil", "drug2": "zopiclone", "interaction_type": 76, "interaction_text": "flumazenil may decrease the sedative activities of zopiclone.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "diphenhydramine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of diphenhydramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "flumazenil", "drug2": "Eszopiclone", "interaction_type": 76, "interaction_text": "flumazenil may decrease the sedative activities of Eszopiclone.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "cimetidine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of cimetidine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "clemastine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of clemastine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "mirtazapine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of mirtazapine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "hydroxyzine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of hydroxyzine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "cimetidine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of cimetidine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "meclizine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of meclizine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "diphenhydramine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of diphenhydramine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "cimetidine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of cimetidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "mirtazapine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of mirtazapine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "mianserin", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of mianserin.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "flumazenil", "drug2": "Tasimelteon", "interaction_type": 76, "interaction_text": "flumazenil may decrease the sedative activities of Tasimelteon.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Lodoxamide", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Lodoxamide.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "flumazenil", "drug2": "Suvorexant", "interaction_type": 76, "interaction_text": "flumazenil may decrease the sedative activities of Suvorexant.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "flumazenil", "drug2": "zaleplon", "interaction_type": 76, "interaction_text": "flumazenil may decrease the sedative activities of zaleplon.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "diphenhydramine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of diphenhydramine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "astemizole", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of astemizole.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "antazoline", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of antazoline.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Dexbrompheniramine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Dexbrompheniramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "promethazine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of promethazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "mianserin", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of mianserin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "thonzylamine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of thonzylamine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "flunarizine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of flunarizine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "DIMETHINDENE", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of DIMETHINDENE.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Isothipendyl", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Isothipendyl.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ROXATIDINE ACETATE", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of ROXATIDINE ACETATE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "emedastine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of emedastine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Mepyramine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Mepyramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Phenindamine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Phenindamine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "fexofenadine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of fexofenadine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "tripelennamine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of tripelennamine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "flumazenil", "drug2": "Ramelteon", "interaction_type": 76, "interaction_text": "flumazenil may decrease the sedative activities of Ramelteon.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "doxepin", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of doxepin.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ranitidine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of ranitidine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "ethopropazine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of ethopropazine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "trimeprazine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of trimeprazine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Alcaftadine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Alcaftadine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "Pemirolast", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of Pemirolast.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "cinnarizine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of cinnarizine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "doxepin", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of doxepin.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "clemastine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of clemastine.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "epinastine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of epinastine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "loratadine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of loratadine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "doxylamine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of doxylamine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "benztropine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of benztropine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "ACRIVASTINE", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of ACRIVASTINE.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Dexchlorpheniramine maleate", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of Dexchlorpheniramine maleate.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Olopatadine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Olopatadine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "famotidine", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of famotidine.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "CYPROHEPTADINE", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of CYPROHEPTADINE.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "ketotifen", "interaction_type": 76, "interaction_text": "dextroamphetamine may decrease the sedative activities of ketotifen.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "chlorpheniramine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of chlorpheniramine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "nizatidine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of nizatidine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "triprolidine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of triprolidine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "Levocetirizine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of Levocetirizine.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "cetirizine", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of cetirizine.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Desloratadine", "interaction_type": 76, "interaction_text": "AMPHETAMINE may decrease the sedative activities of Desloratadine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "hydroxyamphetamine", "drug2": "mianserin", "interaction_type": 76, "interaction_text": "hydroxyamphetamine may decrease the sedative activities of mianserin.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "mequitazine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of mequitazine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "diphenhydramine", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of diphenhydramine.", "severity": 2}
{"drug1": "benzphetamine", "drug2": "CYCLIZINE", "interaction_type": 76, "interaction_text": "benzphetamine may decrease the sedative activities of CYCLIZINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "DIMENHYDRINATE", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of DIMENHYDRINATE.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Buclizine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Buclizine.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "METHAMPHETAMINE may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "Lisdexamfetamine", "drug2": "Chloropyramine", "interaction_type": 76, "interaction_text": "Lisdexamfetamine may decrease the sedative activities of Chloropyramine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "pheniramine", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of pheniramine.", "severity": 2}
{"drug1": "Amfepramone", "drug2": "cimetidine", "interaction_type": 76, "interaction_text": "Amfepramone may decrease the sedative activities of cimetidine.", "severity": 2}
{"drug1": "MEPHENTERMINE", "drug2": "AZATADINE", "interaction_type": 76, "interaction_text": "MEPHENTERMINE may decrease the sedative activities of AZATADINE.", "severity": 2}
{"drug1": "PSEUDOEPHEDRINE", "drug2": "azelastine", "interaction_type": 76, "interaction_text": "PSEUDOEPHEDRINE may decrease the sedative activities of azelastine.", "severity": 2}
{"drug1": "bromocriptine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with bromocriptine.", "severity": 2}
{"drug1": "Methylnaltrexone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Methylnaltrexone.", "severity": 2}
{"drug1": "timolol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with timolol.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with nelfinavir.", "severity": 2}
{"drug1": "AMPHETAMINE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with AMPHETAMINE.", "severity": 2}
{"drug1": "Vitamin D3", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Vitamin D3.", "severity": 2}
{"drug1": "cimetidine", "drug2": "tegafur", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of tegafur can be increased when tegafur is used in combination with cimetidine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Atazanavir.", "severity": 2}
{"drug1": "citalopram", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with citalopram.", "severity": 2}
{"drug1": "isoniazid", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with isoniazid.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with vinorelbine.", "severity": 2}
{"drug1": "Crizotinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Crizotinib.", "severity": 2}
{"drug1": "metyrapone", "drug2": "Propacetamol", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Propacetamol can be increased when Propacetamol is used in combination with metyrapone.", "severity": 2}
{"drug1": "nisoldipine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with nisoldipine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Fosamprenavir", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with ketoconazole.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Idelalisib.", "severity": 2}
{"drug1": "Pipotiazine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Pipotiazine.", "severity": 2}
{"drug1": "quetiapine", "drug2": "carbamazepine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of carbamazepine can be increased when carbamazepine is used in combination with quetiapine.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Cinacalcet.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with fluvoxamine.", "severity": 2}
{"drug1": "Dasatinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Dasatinib.", "severity": 2}
{"drug1": "Zucapsaicin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Zucapsaicin.", "severity": 2}
{"drug1": "Etoricoxib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Etoricoxib.", "severity": 2}
{"drug1": "sumatriptan", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with sumatriptan.", "severity": 2}
{"drug1": "loratadine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with loratadine.", "severity": 2}
{"drug1": "prednisone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with prednisone.", "severity": 2}
{"drug1": "indinavir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with indinavir.", "severity": 2}
{"drug1": "bupropion", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with bupropion.", "severity": 2}
{"drug1": "sildenafil", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with sildenafil.", "severity": 2}
{"drug1": "palmitic acid", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with palmitic acid.", "severity": 2}
{"drug1": "desipramine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with desipramine.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Cobicistat.", "severity": 2}
{"drug1": "lomustine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with lomustine.", "severity": 2}
{"drug1": "losartan", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with losartan.", "severity": 2}
{"drug1": "Febuxostat", "drug2": "theophylline", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of theophylline can be increased when theophylline is used in combination with Febuxostat.", "severity": 2}
{"drug1": "rabeprazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with rabeprazole.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with ritonavir.", "severity": 2}
{"drug1": "doxazosin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with doxazosin.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nelfinavir.", "severity": 2}
{"drug1": "Fosamprenavir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with Fosamprenavir.", "severity": 2}
{"drug1": "amprenavir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with amprenavir.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with pentobarbital.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "primidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of primidone can be increased when primidone is used in combination with methylphenidate.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with nefazodone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with venlafaxine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Temsirolimus", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with ketoconazole.", "severity": 2}
{"drug1": "buspirone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with buspirone.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with trimethoprim.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with cimetidine.", "severity": 2}
{"drug1": "acetaminophen", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with acetaminophen.", "severity": 2}
{"drug1": "Naloxegol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Naloxegol.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Posaconazole.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Dexmethylphenidate.", "severity": 2}
{"drug1": "astemizole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with astemizole.", "severity": 2}
{"drug1": "metronidazole", "drug2": "CAPECITABINE", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of CAPECITABINE can be increased when CAPECITABINE is used in combination with metronidazole.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Cobicistat.", "severity": 2}
{"drug1": "selegiline", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with selegiline.", "severity": 2}
{"drug1": "Dexmethylphenidate", "drug2": "primidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of primidone can be increased when primidone is used in combination with Dexmethylphenidate.", "severity": 2}
{"drug1": "Yohimbine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Yohimbine.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with paroxetine.", "severity": 2}
{"drug1": "estramustine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with estramustine.", "severity": 2}
{"drug1": "tioconazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with tioconazole.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Fosamprenavir", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Voriconazole.", "severity": 2}
{"drug1": "ritonavir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with ritonavir.", "severity": 2}
{"drug1": "propofol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with propofol.", "severity": 2}
{"drug1": "colchicine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with colchicine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with pravastatin.", "severity": 2}
{"drug1": "Velpatasvir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Velpatasvir.", "severity": 2}
{"drug1": "ticlopidine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ticlopidine.", "severity": 2}
{"drug1": "Febuxostat", "drug2": "dyphylline", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of dyphylline can be increased when dyphylline is used in combination with Febuxostat.", "severity": 2}
{"drug1": "chlorpropamide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with chlorpropamide.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Gefitinib.", "severity": 2}
{"drug1": "Lumefantrine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lumefantrine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with carbamazepine.", "severity": 2}
{"drug1": "Pioglitazone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Pioglitazone.", "severity": 2}
{"drug1": "cilazapril", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with cilazapril.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Imatinib.", "severity": 2}
{"drug1": "fluvastatin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with fluvastatin.", "severity": 2}
{"drug1": "Candesartan cilexetil", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Candesartan cilexetil.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with doxorubicin.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Voriconazole.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telaprevir.", "severity": 2}
{"drug1": "oxamniquine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with oxamniquine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with RIFAPENTINE.", "severity": 2}
{"drug1": "labetalol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with labetalol.", "severity": 2}
{"drug1": "Letermovir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Letermovir.", "severity": 2}
{"drug1": "sertraline", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with sertraline.", "severity": 2}
{"drug1": "quinidine", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with quinidine.", "severity": 2}
{"drug1": "Fidaxomicin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Fidaxomicin.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Telithromycin.", "severity": 2}
{"drug1": "morphine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with morphine.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ketoconazole.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Midostaurin.", "severity": 2}
{"drug1": "pimozide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with pimozide.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with haloperidol.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with oxybutynin.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Desloratadine.", "severity": 2}
{"drug1": "primidone", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with primidone.", "severity": 2}
{"drug1": "nitrendipine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with nitrendipine.", "severity": 2}
{"drug1": "triflupromazine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with triflupromazine.", "severity": 2}
{"drug1": "Caspofungin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Caspofungin.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with ketoconazole.", "severity": 2}
{"drug1": "vinorelbine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with vinorelbine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with FLUPHENAZINE.", "severity": 2}
{"drug1": "felodipine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with felodipine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Idelalisib.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with paroxetine.", "severity": 2}
{"drug1": "pimozide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with pimozide.", "severity": 2}
{"drug1": "erythromycin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with erythromycin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Boceprevir.", "severity": 2}
{"drug1": "GLYCEROL PHENYLBUTYRATE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with GLYCEROL PHENYLBUTYRATE.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ranitidine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Fosamprenavir", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Posaconazole.", "severity": 2}
{"drug1": "indinavir", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with indinavir.", "severity": 2}
{"drug1": "cyclophosphamide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with cyclophosphamide.", "severity": 2}
{"drug1": "methadone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with methadone.", "severity": 2}
{"drug1": "bepridil", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with bepridil.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Dronedarone.", "severity": 2}
{"drug1": "Fosphenytoin", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with Fosphenytoin.", "severity": 2}
{"drug1": "scopolamine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with scopolamine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with nelfinavir.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with dexamethasone.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with clarithromycin.", "severity": 2}
{"drug1": "Propoxyphene napsylate", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Propoxyphene napsylate.", "severity": 2}
{"drug1": "hydroxyzine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with hydroxyzine.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with nicardipine.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with clotrimazole.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with venlafaxine.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with Lumacaftor.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with phenobarbital.", "severity": 2}
{"drug1": "Tramadol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Tramadol.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with tamoxifen.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with VERAPAMIL.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with mirtazapine.", "severity": 2}
{"drug1": "cimetidine", "drug2": "floxuridine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of floxuridine can be increased when floxuridine is used in combination with cimetidine.", "severity": 2}
{"drug1": "carvedilol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with carvedilol.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with metoprolol.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Voriconazole.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with buprenorphine.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with ketoconazole.", "severity": 2}
{"drug1": "SIMEPREVIR", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with SIMEPREVIR.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Rolapitant.", "severity": 2}
{"drug1": "Halofantrine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Halofantrine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with itraconazole.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with clarithromycin.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with lidocaine.", "severity": 2}
{"drug1": "mitomycin C", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with mitomycin C.", "severity": 2}
{"drug1": "Telmisartan", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Telmisartan.", "severity": 2}
{"drug1": "digoxin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with digoxin.", "severity": 2}
{"drug1": "felodipine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with felodipine.", "severity": 2}
{"drug1": "Ziprasidone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ziprasidone.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ritonavir.", "severity": 2}
{"drug1": "Gefitinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Gefitinib.", "severity": 2}
{"drug1": "trifluoperazine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with trifluoperazine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with nevirapine.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with terbinafine.", "severity": 2}
{"drug1": "mifepristone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with mifepristone.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Telaprevir.", "severity": 2}
{"drug1": "Imatinib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Imatinib.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with itraconazole.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Reboxetine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with Darunavir.", "severity": 2}
{"drug1": "METHAMPHETAMINE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with METHAMPHETAMINE.", "severity": 2}
{"drug1": "atenolol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with atenolol.", "severity": 2}
{"drug1": "amodiaquine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with amodiaquine.", "severity": 2}
{"drug1": "miconazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with miconazole.", "severity": 2}
{"drug1": "mebendazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with mebendazole.", "severity": 2}
{"drug1": "Midostaurin", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Midostaurin.", "severity": 2}
{"drug1": "glyburide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with glyburide.", "severity": 2}
{"drug1": "Daclatasvir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Daclatasvir.", "severity": 2}
{"drug1": "olanzapine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with olanzapine.", "severity": 2}
{"drug1": "efavirenz", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with efavirenz.", "severity": 2}
{"drug1": "midodrine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with midodrine.", "severity": 2}
{"drug1": "FLUPHENAZINE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with FLUPHENAZINE.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Posaconazole.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with lansoprazole.", "severity": 2}
{"drug1": "Vilazodone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Vilazodone.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with fexofenadine.", "severity": 2}
{"drug1": "Lomitapide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Lomitapide.", "severity": 2}
{"drug1": "Bortezomib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Bortezomib.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Idelalisib.", "severity": 2}
{"drug1": "imipramine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with imipramine.", "severity": 2}
{"drug1": "doxepin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with doxepin.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with lovastatin.", "severity": 2}
{"drug1": "tamoxifen", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with tamoxifen.", "severity": 2}
{"drug1": "betaxolol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with betaxolol.", "severity": 2}
{"drug1": "nicardipine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nicardipine.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Darunavir.", "severity": 2}
{"drug1": "MEGESTROL ACETATE", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with MEGESTROL ACETATE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with clomipramine.", "severity": 2}
{"drug1": "ranitidine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with ranitidine.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with nelfinavir.", "severity": 2}
{"drug1": "quetiapine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with quetiapine.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with cyclosporin A.", "severity": 2}
{"drug1": "methylphenidate", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with methylphenidate.", "severity": 2}
{"drug1": "cocaine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with cocaine.", "severity": 2}
{"drug1": "Voriconazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Voriconazole.", "severity": 2}
{"drug1": "haloperidol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with haloperidol.", "severity": 2}
{"drug1": "proguanil", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with proguanil.", "severity": 2}
{"drug1": "nitrazepam", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with nitrazepam.", "severity": 2}
{"drug1": "promazine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with promazine.", "severity": 2}
{"drug1": "ALFENTANIL", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with ALFENTANIL.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with Rifampicin.", "severity": 2}
{"drug1": "rosiglitazone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with rosiglitazone.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with diltiazem.", "severity": 2}
{"drug1": "acebutolol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with acebutolol.", "severity": 2}
{"drug1": "Temsirolimus", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Temsirolimus.", "severity": 2}
{"drug1": "codeine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with codeine.", "severity": 2}
{"drug1": "Sunitinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Sunitinib.", "severity": 2}
{"drug1": "IDARUBICIN", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with IDARUBICIN.", "severity": 2}
{"drug1": "cyclosporin A", "drug2": "prednisone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of prednisone can be increased when prednisone is used in combination with cyclosporin A.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Atazanavir.", "severity": 2}
{"drug1": "miconazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with miconazole.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with nifedipine.", "severity": 2}
{"drug1": "diclofenac", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with diclofenac.", "severity": 2}
{"drug1": "daunorubicin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with daunorubicin.", "severity": 2}
{"drug1": "clemastine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with clemastine.", "severity": 2}
{"drug1": "RIFAPENTINE", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with RIFAPENTINE.", "severity": 2}
{"drug1": "Canagliflozin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Canagliflozin.", "severity": 2}
{"drug1": "spironolactone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with spironolactone.", "severity": 2}
{"drug1": "terbinafine", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with terbinafine.", "severity": 2}
{"drug1": "Rolapitant", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Rolapitant.", "severity": 2}
{"drug1": "ELIGLUSTAT", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ELIGLUSTAT.", "severity": 2}
{"drug1": "Artemether", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Artemether.", "severity": 2}
{"drug1": "Flupentixol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Flupentixol.", "severity": 2}
{"drug1": "Afatinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Afatinib.", "severity": 2}
{"drug1": "phenobarbital", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with phenobarbital.", "severity": 2}
{"drug1": "Escitalopram", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Escitalopram.", "severity": 2}
{"drug1": "imipramine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with imipramine.", "severity": 2}
{"drug1": "azithromycin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with azithromycin.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with amitriptyline.", "severity": 2}
{"drug1": "rapamycin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with rapamycin.", "severity": 2}
{"drug1": "Levomepromazine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Levomepromazine.", "severity": 2}
{"drug1": "IVERMECTIN", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with IVERMECTIN.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Roflumilast", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Roflumilast can be increased when Roflumilast is used in combination with fluvoxamine.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with Rifampicin.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with cimetidine.", "severity": 2}
{"drug1": "oxprenolol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with oxprenolol.", "severity": 2}
{"drug1": "TROLEANDOMYCIN", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with TROLEANDOMYCIN.", "severity": 2}
{"drug1": "pentamidine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with pentamidine.", "severity": 2}
{"drug1": "allopurinol", "drug2": "azathioprine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of azathioprine can be increased when azathioprine is used in combination with allopurinol.", "severity": 2}
{"drug1": "risperidone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with risperidone.", "severity": 2}
{"drug1": "fluvoxamine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with fluvoxamine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with amiodarone.", "severity": 2}
{"drug1": "Reboxetine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Reboxetine.", "severity": 2}
{"drug1": "clozapine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with clozapine.", "severity": 2}
{"drug1": "VALPROIC ACID", "drug2": "carbamazepine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of carbamazepine can be increased when carbamazepine is used in combination with VALPROIC ACID.", "severity": 2}
{"drug1": "dolasetron", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with dolasetron.", "severity": 2}
{"drug1": "clotrimazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with clotrimazole.", "severity": 2}
{"drug1": "Tolvaptan", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Tolvaptan.", "severity": 2}
{"drug1": "Mepyramine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Mepyramine.", "severity": 2}
{"drug1": "pravastatin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with pravastatin.", "severity": 2}
{"drug1": "rivastigmine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with rivastigmine.", "severity": 2}
{"drug1": "PONATINIB", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with PONATINIB.", "severity": 2}
{"drug1": "mitoxantrone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with mitoxantrone.", "severity": 2}
{"drug1": "testosterone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with testosterone.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "DEXMEDETOMIDINE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ajmaline.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Enasidenib.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Darunavir.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with RIFABUTIN.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Atazanavir.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with vinblastine.", "severity": 2}
{"drug1": "biperiden", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with biperiden.", "severity": 2}
{"drug1": "lovastatin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with lovastatin.", "severity": 2}
{"drug1": "probenecid", "drug2": "GLYCEROL PHENYLBUTYRATE", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of GLYCEROL PHENYLBUTYRATE can be increased when GLYCEROL PHENYLBUTYRATE is used in combination with probenecid.", "severity": 2}
{"drug1": "Pibrentasvir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Pibrentasvir.", "severity": 2}
{"drug1": "metoclopramide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with metoclopramide.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with clomipramine.", "severity": 2}
{"drug1": "fexofenadine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with fexofenadine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Atomoxetine.", "severity": 2}
{"drug1": "methimazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with methimazole.", "severity": 2}
{"drug1": "enalapril", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with enalapril.", "severity": 2}
{"drug1": "pentobarbital", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with pentobarbital.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Fosamprenavir", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with itraconazole.", "severity": 2}
{"drug1": "primidone", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with primidone.", "severity": 2}
{"drug1": "etoposide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with etoposide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Lopinavir.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Regorafenib.", "severity": 2}
{"drug1": "cocaine", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with cocaine.", "severity": 2}
{"drug1": "cisapride", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with cisapride.", "severity": 2}
{"drug1": "Glecaprevir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Glecaprevir.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with thioridazine.", "severity": 2}
{"drug1": "phenytoin", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with phenytoin.", "severity": 2}
{"drug1": "sulfaphenazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with sulfaphenazole.", "severity": 2}
{"drug1": "gemfibrozil", "drug2": "irinotecan", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of irinotecan can be increased when irinotecan is used in combination with gemfibrozil.", "severity": 2}
{"drug1": "albendazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with albendazole.", "severity": 2}
{"drug1": "promethazine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with promethazine.", "severity": 2}
{"drug1": "nevirapine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nevirapine.", "severity": 2}
{"drug1": "Mirabegron", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Mirabegron.", "severity": 2}
{"drug1": "ketoconazole", "drug2": "Fingolimod", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fingolimod can be increased when Fingolimod is used in combination with ketoconazole.", "severity": 2}
{"drug1": "nifedipine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nifedipine.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with dextromethorphan.", "severity": 2}
{"drug1": "CARTEOLOL", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with CARTEOLOL.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Sorafenib.", "severity": 2}
{"drug1": "Regorafenib", "drug2": "irinotecan", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of irinotecan can be increased when irinotecan is used in combination with Regorafenib.", "severity": 2}
{"drug1": "dextromethorphan", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with dextromethorphan.", "severity": 2}
{"drug1": "meprobamate", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with meprobamate.", "severity": 2}
{"drug1": "Febuxostat", "drug2": "aminophylline", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of aminophylline can be increased when aminophylline is used in combination with Febuxostat.", "severity": 2}
{"drug1": "Darunavir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Darunavir.", "severity": 2}
{"drug1": "Enasidenib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Enasidenib.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with itraconazole.", "severity": 2}
{"drug1": "RANOLAZINE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with RANOLAZINE.", "severity": 2}
{"drug1": "thiothixene", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with thiothixene.", "severity": 2}
{"drug1": "nelfinavir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with nelfinavir.", "severity": 2}
{"drug1": "diphenhydramine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with diphenhydramine.", "severity": 2}
{"drug1": "histamine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with histamine.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Atazanavir.", "severity": 2}
{"drug1": "metoprolol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with metoprolol.", "severity": 2}
{"drug1": "methoxsalen", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with methoxsalen.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Rifampicin.", "severity": 2}
{"drug1": "PRIMAQUINE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with PRIMAQUINE.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with itraconazole.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with amiodarone.", "severity": 2}
{"drug1": "Lercanidipine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lercanidipine.", "severity": 2}
{"drug1": "Idelalisib", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Idelalisib.", "severity": 2}
{"drug1": "progesterone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with progesterone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Dronabinol.", "severity": 2}
{"drug1": "lansoprazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with lansoprazole.", "severity": 2}
{"drug1": "cimetidine", "drug2": "CAPECITABINE", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of CAPECITABINE can be increased when CAPECITABINE is used in combination with cimetidine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Telaprevir.", "severity": 2}
{"drug1": "ERGOTAMINE", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with ERGOTAMINE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with amitriptyline.", "severity": 2}
{"drug1": "ketamine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with ketamine.", "severity": 2}
{"drug1": "Vernakalant", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Vernakalant.", "severity": 2}
{"drug1": "flurazepam", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with flurazepam.", "severity": 2}
{"drug1": "terazosin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with terazosin.", "severity": 2}
{"drug1": "disulfiram", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with disulfiram.", "severity": 2}
{"drug1": "Gimeracil", "drug2": "CAPECITABINE", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of CAPECITABINE can be increased when CAPECITABINE is used in combination with Gimeracil.", "severity": 2}
{"drug1": "Isavuconazonium", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Isavuconazonium.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with simvastatin.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with omeprazole.", "severity": 2}
{"drug1": "epinastine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with epinastine.", "severity": 2}
{"drug1": "Lapatinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Lapatinib.", "severity": 2}
{"drug1": "antipyrine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with antipyrine.", "severity": 2}
{"drug1": "Bosentan", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with Bosentan.", "severity": 2}
{"drug1": "biperiden", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with biperiden.", "severity": 2}
{"drug1": "trimethoprim", "drug2": "PROCAINAMIDE", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of PROCAINAMIDE can be increased when PROCAINAMIDE is used in combination with trimethoprim.", "severity": 2}
{"drug1": "pergolide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with pergolide.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with Lopinavir.", "severity": 2}
{"drug1": "irbesartan", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with irbesartan.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with duloxetine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with chloroquine.", "severity": 2}
{"drug1": "LEVOFLOXACIN", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with LEVOFLOXACIN.", "severity": 2}
{"drug1": "loperamide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with loperamide.", "severity": 2}
{"drug1": "CABAZITAXEL", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with CABAZITAXEL.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with fluoxetine.", "severity": 2}
{"drug1": "propoxyphene", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with propoxyphene.", "severity": 2}
{"drug1": "desipramine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with desipramine.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telithromycin.", "severity": 2}
{"drug1": "hydroxyurea", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with hydroxyurea.", "severity": 2}
{"drug1": "quinacrine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with quinacrine.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Levalbuterol.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ceritinib.", "severity": 2}
{"drug1": "chlorprothixene", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with chlorprothixene.", "severity": 2}
{"drug1": "quinidine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with quinidine.", "severity": 2}
{"drug1": "probenecid", "drug2": "4-PHENYLBUTYRIC ACID", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of 4-PHENYLBUTYRIC ACID can be increased when 4-PHENYLBUTYRIC ACID is used in combination with probenecid.", "severity": 2}
{"drug1": "Aripiprazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Aripiprazole.", "severity": 2}
{"drug1": "pantoprazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with pantoprazole.", "severity": 2}
{"drug1": "Lumacaftor", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Lumacaftor.", "severity": 2}
{"drug1": "doxepin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with doxepin.", "severity": 2}
{"drug1": "granisetron", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with granisetron.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "citalopram", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with citalopram.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with mefloquine.", "severity": 2}
{"drug1": "midazolam", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with midazolam.", "severity": 2}
{"drug1": "probenecid", "drug2": "oseltamivir", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of oseltamivir can be increased when oseltamivir is used in combination with probenecid.", "severity": 2}
{"drug1": "selegiline", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with selegiline.", "severity": 2}
{"drug1": "Cinacalcet", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Cinacalcet.", "severity": 2}
{"drug1": "loxapine", "drug2": "carbamazepine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of carbamazepine can be increased when carbamazepine is used in combination with loxapine.", "severity": 2}
{"drug1": "perphenazine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with perphenazine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with trimipramine.", "severity": 2}
{"drug1": "Quinine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Quinine.", "severity": 2}
{"drug1": "promethazine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with promethazine.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Cobicistat.", "severity": 2}
{"drug1": "amsacrine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with amsacrine.", "severity": 2}
{"drug1": "Voxilaprevir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Voxilaprevir.", "severity": 2}
{"drug1": "ondansetron", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ondansetron.", "severity": 2}
{"drug1": "diltiazem", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with diltiazem.", "severity": 2}
{"drug1": "nicotinic acid", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nicotinic acid.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Temsirolimus", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with Posaconazole.", "severity": 2}
{"drug1": "dextroamphetamine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with dextroamphetamine.", "severity": 2}
{"drug1": "sulconazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with sulconazole.", "severity": 2}
{"drug1": "CYPROTERONE ACETATE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with CYPROTERONE ACETATE.", "severity": 2}
{"drug1": "maprotiline", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with maprotiline.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Nilotinib.", "severity": 2}
{"drug1": "ritonavir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with ritonavir.", "severity": 2}
{"drug1": "mefloquine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with mefloquine.", "severity": 2}
{"drug1": "indinavir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with indinavir.", "severity": 2}
{"drug1": "Lorcaserin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lorcaserin.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with RUCAPARIB.", "severity": 2}
{"drug1": "Rotigotine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Rotigotine.", "severity": 2}
{"drug1": "amantadine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with amantadine.", "severity": 2}
{"drug1": "oxymetholone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with oxymetholone.", "severity": 2}
{"drug1": "prazosin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with prazosin.", "severity": 2}
{"drug1": "Ivacaftor", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Ivacaftor.", "severity": 2}
{"drug1": "RIFABUTIN", "drug2": "clarithromycin", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of clarithromycin can be increased when clarithromycin is used in combination with RIFABUTIN.", "severity": 2}
{"drug1": "propafenone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with propafenone.", "severity": 2}
{"drug1": "captopril", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with captopril.", "severity": 2}
{"drug1": "methazolamide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with methazolamide.", "severity": 2}
{"drug1": "indomethacin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with indomethacin.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Delavirdine.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with fluoxetine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lopinavir.", "severity": 2}
{"drug1": "hydroxychloroquine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with hydroxychloroquine.", "severity": 2}
{"drug1": "doxorubicin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with doxorubicin.", "severity": 2}
{"drug1": "propranolol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with propranolol.", "severity": 2}
{"drug1": "Rifampicin", "drug2": "leflunomide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of leflunomide can be increased when leflunomide is used in combination with Rifampicin.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with amiodarone.", "severity": 2}
{"drug1": "ribavirin", "drug2": "azathioprine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of azathioprine can be increased when azathioprine is used in combination with ribavirin.", "severity": 2}
{"drug1": "cimetidine", "drug2": "Roflumilast", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Roflumilast can be increased when Roflumilast is used in combination with cimetidine.", "severity": 2}
{"drug1": "reserpine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with reserpine.", "severity": 2}
{"drug1": "Nilotinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Nilotinib.", "severity": 2}
{"drug1": "probenecid", "drug2": "Propacetamol", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Propacetamol can be increased when Propacetamol is used in combination with probenecid.", "severity": 2}
{"drug1": "Diacerein", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Diacerein.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Boceprevir.", "severity": 2}
{"drug1": "Gimeracil", "drug2": "floxuridine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of floxuridine can be increased when floxuridine is used in combination with Gimeracil.", "severity": 2}
{"drug1": "celecoxib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with celecoxib.", "severity": 2}
{"drug1": "moclobemide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with moclobemide.", "severity": 2}
{"drug1": "paroxetine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with paroxetine.", "severity": 2}
{"drug1": "carbamazepine", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with carbamazepine.", "severity": 2}
{"drug1": "Tapentadol", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Tapentadol.", "severity": 2}
{"drug1": "dihydroergotamine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with dihydroergotamine.", "severity": 2}
{"drug1": "nicotinamide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nicotinamide.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "probenecid", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with probenecid.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Dothiepin.", "severity": 2}
{"drug1": "Boceprevir", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Boceprevir.", "severity": 2}
{"drug1": "phenytoin", "drug2": "ifosfamide", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of ifosfamide can be increased when ifosfamide is used in combination with phenytoin.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nortriptyline.", "severity": 2}
{"drug1": "Delavirdine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Delavirdine.", "severity": 2}
{"drug1": "methadone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with methadone.", "severity": 2}
{"drug1": "Dexfenfluramine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Dexfenfluramine.", "severity": 2}
{"drug1": "metronidazole", "drug2": "tegafur", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of tegafur can be increased when tegafur is used in combination with metronidazole.", "severity": 2}
{"drug1": "ropinirole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with ropinirole.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with ciprofloxacin.", "severity": 2}
{"drug1": "Atazanavir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with Atazanavir.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with SAQUINAVIR.", "severity": 2}
{"drug1": "vincristine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with vincristine.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Lopinavir.", "severity": 2}
{"drug1": "indinavir", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with indinavir.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with protriptyline.", "severity": 2}
{"drug1": "bicalutamide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with bicalutamide.", "severity": 2}
{"drug1": "vinblastine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with vinblastine.", "severity": 2}
{"drug1": "chloroquine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with chloroquine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Posaconazole.", "severity": 2}
{"drug1": "aspirin", "drug2": "carisoprodol", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of carisoprodol can be increased when carisoprodol is used in combination with aspirin.", "severity": 2}
{"drug1": "clarithromycin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with clarithromycin.", "severity": 2}
{"drug1": "Pazopanib", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Pazopanib.", "severity": 2}
{"drug1": "glycerol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with glycerol.", "severity": 2}
{"drug1": "propafenone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with propafenone.", "severity": 2}
{"drug1": "Ospemifene", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ospemifene.", "severity": 2}
{"drug1": "Sorafenib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Sorafenib.", "severity": 2}
{"drug1": "fluoxetine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with fluoxetine.", "severity": 2}
{"drug1": "indinavir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with indinavir.", "severity": 2}
{"drug1": "PERINDOPRIL", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with PERINDOPRIL.", "severity": 2}
{"drug1": "zafirlukast", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with zafirlukast.", "severity": 2}
{"drug1": "Abemaciclib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Abemaciclib.", "severity": 2}
{"drug1": "Cobicistat", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Cobicistat.", "severity": 2}
{"drug1": "chlorpheniramine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with chlorpheniramine.", "severity": 2}
{"drug1": "flecainide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with flecainide.", "severity": 2}
{"drug1": "Ticagrelor", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ticagrelor.", "severity": 2}
{"drug1": "felbamate", "drug2": "primidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of primidone can be increased when primidone is used in combination with felbamate.", "severity": 2}
{"drug1": "VERAPAMIL", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with VERAPAMIL.", "severity": 2}
{"drug1": "Quinine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Quinine.", "severity": 2}
{"drug1": "Enzalutamide", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Enzalutamide.", "severity": 2}
{"drug1": "4-PHENYLBUTYRIC ACID", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with 4-PHENYLBUTYRIC ACID.", "severity": 2}
{"drug1": "bupropion", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with bupropion.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with ceritinib.", "severity": 2}
{"drug1": "tranylcypromine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with tranylcypromine.", "severity": 2}
{"drug1": "azelastine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with azelastine.", "severity": 2}
{"drug1": "pyrimethamine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with pyrimethamine.", "severity": 2}
{"drug1": "fluconazole", "drug2": "Temsirolimus", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with fluconazole.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with nefazodone.", "severity": 2}
{"drug1": "Telithromycin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Telithromycin.", "severity": 2}
{"drug1": "Gramicidin D", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Gramicidin D.", "severity": 2}
{"drug1": "Trospium", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Trospium.", "severity": 2}
{"drug1": "sulfanilamide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with sulfanilamide.", "severity": 2}
{"drug1": "actinomycin D", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with actinomycin D.", "severity": 2}
{"drug1": "tripelennamine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with tripelennamine.", "severity": 2}
{"drug1": "clofazimine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with clofazimine.", "severity": 2}
{"drug1": "lidocaine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with lidocaine.", "severity": 2}
{"drug1": "Posaconazole", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Posaconazole.", "severity": 2}
{"drug1": "fluconazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with fluconazole.", "severity": 2}
{"drug1": "RUCAPARIB", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with RUCAPARIB.", "severity": 2}
{"drug1": "PERHEXILINE", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with PERHEXILINE.", "severity": 2}
{"drug1": "nefazodone", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with nefazodone.", "severity": 2}
{"drug1": "naltrexone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with naltrexone.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Dothiepin.", "severity": 2}
{"drug1": "loratadine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with loratadine.", "severity": 2}
{"drug1": "Telaprevir", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Telaprevir.", "severity": 2}
{"drug1": "Lopinavir", "drug2": "Isavuconazonium", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Lopinavir.", "severity": 2}
{"drug1": "triprolidine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with triprolidine.", "severity": 2}
{"drug1": "simvastatin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with simvastatin.", "severity": 2}
{"drug1": "Gimeracil", "drug2": "5-Fluorocytosine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of 5-Fluorocytosine can be increased when 5-Fluorocytosine is used in combination with Gimeracil.", "severity": 2}
{"drug1": "Desloratadine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Desloratadine.", "severity": 2}
{"drug1": "omeprazole", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with omeprazole.", "severity": 2}
{"drug1": "caffeine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with caffeine.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with hydrocortisone.", "severity": 2}
{"drug1": "propranolol", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with propranolol.", "severity": 2}
{"drug1": "Asenapine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Asenapine.", "severity": 2}
{"drug1": "itraconazole", "drug2": "Temsirolimus", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with itraconazole.", "severity": 2}
{"drug1": "atorvastatin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with atorvastatin.", "severity": 2}
{"drug1": "buprenorphine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with buprenorphine.", "severity": 2}
{"drug1": "mianserin", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with mianserin.", "severity": 2}
{"drug1": "praziquantel", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with praziquantel.", "severity": 2}
{"drug1": "NEOSTIGMINE", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with NEOSTIGMINE.", "severity": 2}
{"drug1": "Elvitegravir", "drug2": "RIFABUTIN", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of RIFABUTIN can be increased when RIFABUTIN is used in combination with Elvitegravir.", "severity": 2}
{"drug1": "benzocaine", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with benzocaine.", "severity": 2}
{"drug1": "manidipine", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with manidipine.", "severity": 2}
{"drug1": "dimethyl sulfoxide", "drug2": "Fesoterodine", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with dimethyl sulfoxide.", "severity": 2}
{"drug1": "sertraline", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with sertraline.", "severity": 2}
{"drug1": "thioridazine", "drug2": "Iloperidone", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with thioridazine.", "severity": 2}
{"drug1": "Bosutinib", "drug2": "Dabigatran etexilate", "interaction_type": 77, "interaction_text": "The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Bosutinib.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Tixocortol", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of Tixocortol.", "severity": 2}
{"drug1": "ceritinib", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "desoximetasone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of desoximetasone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "medrysone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of medrysone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "CLOCORTOLONE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of CLOCORTOLONE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "equilin", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of equilin.", "severity": 2}
{"drug1": "ceritinib", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Halobetasol", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of Halobetasol.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Clobetasone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of Clobetasone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "formestane", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of formestane.", "severity": 2}
{"drug1": "ceritinib", "drug2": "PREDNICARBATE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of PREDNICARBATE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "loteprednol", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of loteprednol.", "severity": 2}
{"drug1": "ceritinib", "drug2": "RIMEXOLONE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of RIMEXOLONE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Mometasone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of Mometasone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "flumethasone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of flumethasone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "DESONIDE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of DESONIDE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "amcinonide", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of amcinonide.", "severity": 2}
{"drug1": "ceritinib", "drug2": "fludrocortisone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of fludrocortisone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "difluprednate", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of difluprednate.", "severity": 2}
{"drug1": "ceritinib", "drug2": "diflorasone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of diflorasone.", "severity": 2}
{"drug1": "ceritinib", "drug2": "FLUOCORTOLONE", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of FLUOCORTOLONE.", "severity": 2}
{"drug1": "ceritinib", "drug2": "Fluprednidene", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of Fluprednidene.", "severity": 2}
{"drug1": "ceritinib", "drug2": "halcinonide", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of halcinonide.", "severity": 2}
{"drug1": "ceritinib", "drug2": "flurandrenolide", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of flurandrenolide.", "severity": 2}
{"drug1": "ceritinib", "drug2": "fluocinonide", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of fluocinonide.", "severity": 2}
{"drug1": "ceritinib", "drug2": "betamethasone", "interaction_type": 78, "interaction_text": "ceritinib may increase the hyperglycemic activities of betamethasone.", "severity": 2}
{"drug1": "Pirlindole", "drug2": "SUFENTANIL", "interaction_type": 79, "interaction_text": "Pirlindole may increase the central nervous system depressant (CNS depressant) and hypertensive activities of SUFENTANIL.", "severity": 3}
{"drug1": "isocarboxazid", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "isocarboxazid may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "Phenelzine", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "Phenelzine may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "furazolidone", "drug2": "SUFENTANIL", "interaction_type": 79, "interaction_text": "furazolidone may increase the central nervous system depressant (CNS depressant) and hypertensive activities of SUFENTANIL.", "severity": 3}
{"drug1": "selegiline", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "selegiline may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "moclobemide", "drug2": "REMIFENTANIL", "interaction_type": 79, "interaction_text": "moclobemide may increase the central nervous system depressant (CNS depressant) and hypertensive activities of REMIFENTANIL.", "severity": 3}
{"drug1": "pargyline", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "pargyline may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "moclobemide", "drug2": "SUFENTANIL", "interaction_type": 79, "interaction_text": "moclobemide may increase the central nervous system depressant (CNS depressant) and hypertensive activities of SUFENTANIL.", "severity": 3}
{"drug1": "furazolidone", "drug2": "REMIFENTANIL", "interaction_type": 79, "interaction_text": "furazolidone may increase the central nervous system depressant (CNS depressant) and hypertensive activities of REMIFENTANIL.", "severity": 3}
{"drug1": "Pirlindole", "drug2": "REMIFENTANIL", "interaction_type": 79, "interaction_text": "Pirlindole may increase the central nervous system depressant (CNS depressant) and hypertensive activities of REMIFENTANIL.", "severity": 3}
{"drug1": "moclobemide", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "moclobemide may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "pargyline", "drug2": "REMIFENTANIL", "interaction_type": 79, "interaction_text": "pargyline may increase the central nervous system depressant (CNS depressant) and hypertensive activities of REMIFENTANIL.", "severity": 3}
{"drug1": "Toloxatone", "drug2": "REMIFENTANIL", "interaction_type": 79, "interaction_text": "Toloxatone may increase the central nervous system depressant (CNS depressant) and hypertensive activities of REMIFENTANIL.", "severity": 3}
{"drug1": "furazolidone", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "furazolidone may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "Toloxatone", "drug2": "SUFENTANIL", "interaction_type": 79, "interaction_text": "Toloxatone may increase the central nervous system depressant (CNS depressant) and hypertensive activities of SUFENTANIL.", "severity": 3}
{"drug1": "rasagiline", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "rasagiline may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "pargyline", "drug2": "SUFENTANIL", "interaction_type": 79, "interaction_text": "pargyline may increase the central nervous system depressant (CNS depressant) and hypertensive activities of SUFENTANIL.", "severity": 3}
{"drug1": "Pirlindole", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "Pirlindole may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "Toloxatone", "drug2": "ALFENTANIL", "interaction_type": 79, "interaction_text": "Toloxatone may increase the central nervous system depressant (CNS depressant) and hypertensive activities of ALFENTANIL.", "severity": 3}
{"drug1": "Imatinib", "drug2": "Propacetamol", "interaction_type": 80, "interaction_text": "Imatinib may increase the hepatotoxic activities of Propacetamol.", "severity": 3}
{"drug1": "quinidine", "drug2": "phenobarbital", "interaction_type": 80, "interaction_text": "quinidine may increase the hepatotoxic activities of phenobarbital.", "severity": 3}
{"drug1": "6-Mercaptopurine", "drug2": "doxorubicin", "interaction_type": 80, "interaction_text": "6-Mercaptopurine may increase the hepatotoxic activities of doxorubicin.", "severity": 3}
{"drug1": "amodiaquine", "drug2": "efavirenz", "interaction_type": 80, "interaction_text": "amodiaquine may increase the hepatotoxic activities of efavirenz.", "severity": 3}
{"drug1": "acetaminophen", "drug2": "ethanol", "interaction_type": 80, "interaction_text": "acetaminophen may increase the hepatotoxic activities of ethanol.", "severity": 3}
{"drug1": "clonazepam", "drug2": "Tetracosactide", "interaction_type": 80, "interaction_text": "clonazepam may increase the hepatotoxic activities of Tetracosactide.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "OXANDROLONE", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of OXANDROLONE.", "severity": 3}
{"drug1": "Rifampicin", "drug2": "pyrazinamide", "interaction_type": 80, "interaction_text": "Rifampicin may increase the hepatotoxic activities of pyrazinamide.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "Lomitapide", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of Lomitapide.", "severity": 3}
{"drug1": "methotrexate", "drug2": "Acitretin", "interaction_type": 80, "interaction_text": "methotrexate may increase the hepatotoxic activities of Acitretin.", "severity": 3}
{"drug1": "Bosentan", "drug2": "glyburide", "interaction_type": 80, "interaction_text": "Bosentan may increase the hepatotoxic activities of glyburide.", "severity": 3}
{"drug1": "zalcitabine", "drug2": "ribavirin", "interaction_type": 80, "interaction_text": "zalcitabine may increase the hepatotoxic activities of ribavirin.", "severity": 3}
{"drug1": "Propacetamol", "drug2": "isoniazid", "interaction_type": 80, "interaction_text": "Propacetamol may increase the hepatotoxic activities of isoniazid.", "severity": 3}
{"drug1": "Pazopanib", "drug2": "simvastatin", "interaction_type": 80, "interaction_text": "Pazopanib may increase the hepatotoxic activities of simvastatin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "NANDROLONE DECANOATE", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of NANDROLONE DECANOATE.", "severity": 3}
{"drug1": "phenobarbital", "drug2": "Tetracosactide", "interaction_type": 80, "interaction_text": "phenobarbital may increase the hepatotoxic activities of Tetracosactide.", "severity": 3}
{"drug1": "abacavir", "drug2": "ribavirin", "interaction_type": 80, "interaction_text": "abacavir may increase the hepatotoxic activities of ribavirin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "danazol", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of danazol.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "testosterone propionate", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of testosterone propionate.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "acetaminophen", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of acetaminophen.", "severity": 3}
{"drug1": "Propacetamol", "drug2": "Mipomersen", "interaction_type": 80, "interaction_text": "Propacetamol may increase the hepatotoxic activities of Mipomersen.", "severity": 3}
{"drug1": "Trabectedin", "drug2": "ethanol", "interaction_type": 80, "interaction_text": "Trabectedin may increase the hepatotoxic activities of ethanol.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "Isotretinoin", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of Isotretinoin.", "severity": 3}
{"drug1": "lamivudine", "drug2": "ribavirin", "interaction_type": 80, "interaction_text": "lamivudine may increase the hepatotoxic activities of ribavirin.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "doxycycline", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of doxycycline.", "severity": 3}
{"drug1": "primidone", "drug2": "Tetracosactide", "interaction_type": 80, "interaction_text": "primidone may increase the hepatotoxic activities of Tetracosactide.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "methyltestosterone", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of methyltestosterone.", "severity": 3}
{"drug1": "Propacetamol", "drug2": "Sorafenib", "interaction_type": 80, "interaction_text": "Propacetamol may increase the hepatotoxic activities of Sorafenib.", "severity": 3}
{"drug1": "Pazopanib", "drug2": "Pitavastatin", "interaction_type": 80, "interaction_text": "Pazopanib may increase the hepatotoxic activities of Pitavastatin.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "chlortetracycline", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of chlortetracycline.", "severity": 3}
{"drug1": "methotrexate", "drug2": "sulfasalazine", "interaction_type": 80, "interaction_text": "methotrexate may increase the hepatotoxic activities of sulfasalazine.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "stanozolol", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of stanozolol.", "severity": 3}
{"drug1": "methotrexate", "drug2": "Alitretinoin", "interaction_type": 80, "interaction_text": "methotrexate may increase the hepatotoxic activities of Alitretinoin.", "severity": 3}
{"drug1": "Emtricitabine", "drug2": "ribavirin", "interaction_type": 80, "interaction_text": "Emtricitabine may increase the hepatotoxic activities of ribavirin.", "severity": 3}
{"drug1": "Propacetamol", "drug2": "Dasatinib", "interaction_type": 80, "interaction_text": "Propacetamol may increase the hepatotoxic activities of Dasatinib.", "severity": 3}
{"drug1": "Pazopanib", "drug2": "Rosuvastatin", "interaction_type": 80, "interaction_text": "Pazopanib may increase the hepatotoxic activities of Rosuvastatin.", "severity": 3}
{"drug1": "phenytoin", "drug2": "Tetracosactide", "interaction_type": 80, "interaction_text": "phenytoin may increase the hepatotoxic activities of Tetracosactide.", "severity": 3}
{"drug1": "Dasatinib", "drug2": "acetaminophen", "interaction_type": 80, "interaction_text": "Dasatinib may increase the hepatotoxic activities of acetaminophen.", "severity": 3}
{"drug1": "Pazopanib", "drug2": "fluvastatin", "interaction_type": 80, "interaction_text": "Pazopanib may increase the hepatotoxic activities of fluvastatin.", "severity": 3}
{"drug1": "stavudine", "drug2": "ribavirin", "interaction_type": 80, "interaction_text": "stavudine may increase the hepatotoxic activities of ribavirin.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "testosterone", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of testosterone.", "severity": 3}
{"drug1": "isoniazid", "drug2": "RIFABUTIN", "interaction_type": 80, "interaction_text": "isoniazid may increase the hepatotoxic activities of RIFABUTIN.", "severity": 3}
{"drug1": "methotrexate", "drug2": "Mipomersen", "interaction_type": 80, "interaction_text": "methotrexate may increase the hepatotoxic activities of Mipomersen.", "severity": 3}
{"drug1": "Pazopanib", "drug2": "Coenzyme Q10", "interaction_type": 80, "interaction_text": "Pazopanib may increase the hepatotoxic activities of Coenzyme Q10.", "severity": 3}
{"drug1": "nitrazepam", "drug2": "Tetracosactide", "interaction_type": 80, "interaction_text": "nitrazepam may increase the hepatotoxic activities of Tetracosactide.", "severity": 3}
{"drug1": "VALPROIC ACID", "drug2": "Tetracosactide", "interaction_type": 80, "interaction_text": "VALPROIC ACID may increase the hepatotoxic activities of Tetracosactide.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "fluoxymesterone", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of fluoxymesterone.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "minocycline", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of minocycline.", "severity": 3}
{"drug1": "Entecavir", "drug2": "ribavirin", "interaction_type": 80, "interaction_text": "Entecavir may increase the hepatotoxic activities of ribavirin.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "amiodarone", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of amiodarone.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "ethanol", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of ethanol.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "tamoxifen", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of tamoxifen.", "severity": 3}
{"drug1": "cyclosporin A", "drug2": "oxymetholone", "interaction_type": 80, "interaction_text": "cyclosporin A may increase the hepatotoxic activities of oxymetholone.", "severity": 3}
{"drug1": "isoniazid", "drug2": "Rifaximin", "interaction_type": 80, "interaction_text": "isoniazid may increase the hepatotoxic activities of Rifaximin.", "severity": 3}
{"drug1": "isoniazid", "drug2": "RIFAPENTINE", "interaction_type": 80, "interaction_text": "isoniazid may increase the hepatotoxic activities of RIFAPENTINE.", "severity": 3}
{"drug1": "Imatinib", "drug2": "acetaminophen", "interaction_type": 80, "interaction_text": "Imatinib may increase the hepatotoxic activities of acetaminophen.", "severity": 3}
{"drug1": "Mipomersen", "drug2": "demeclocycline", "interaction_type": 80, "interaction_text": "Mipomersen may increase the hepatotoxic activities of demeclocycline.", "severity": 3}
{"drug1": "diazepam", "drug2": "Tetracosactide", "interaction_type": 80, "interaction_text": "diazepam may increase the hepatotoxic activities of Tetracosactide.", "severity": 3}
{"drug1": "Pazopanib", "drug2": "lovastatin", "interaction_type": 80, "interaction_text": "Pazopanib may increase the hepatotoxic activities of lovastatin.", "severity": 3}
{"drug1": "cyclophosphamide", "drug2": "azathioprine", "interaction_type": 80, "interaction_text": "cyclophosphamide may increase the hepatotoxic activities of azathioprine.", "severity": 3}
{"drug1": "Sorafenib", "drug2": "acetaminophen", "interaction_type": 80, "interaction_text": "Sorafenib may increase the hepatotoxic activities of acetaminophen.", "severity": 3}
{"drug1": "isoniazid", "drug2": "Rifampicin", "interaction_type": 80, "interaction_text": "isoniazid may increase the hepatotoxic activities of Rifampicin.", "severity": 3}
{"drug1": "Bedaquiline", "drug2": "ethanol", "interaction_type": 80, "interaction_text": "Bedaquiline may increase the hepatotoxic activities of ethanol.", "severity": 3}
{"drug1": "Lomitapide", "drug2": "ethanol", "interaction_type": 80, "interaction_text": "Lomitapide may increase the hepatotoxic activities of ethanol.", "severity": 3}
{"drug1": "tranexamic acid", "drug2": "dienestrol", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of dienestrol.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "dexamethasone", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of dexamethasone.", "severity": 2}
{"drug1": "GESTODENE", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "GESTODENE may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "thalidomide", "drug2": "NORGESTIMATE", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of NORGESTIMATE.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "ethinyl estradiol may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "mestranol", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "mestranol may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "estrone", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "estrone may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "ethinyl estradiol may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ETONOGESTREL", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of ETONOGESTREL.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "QUINESTROL may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "NORGESTIMATE", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "NORGESTIMATE may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "tibolone", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "tibolone may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "tibolone", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of tibolone.", "severity": 2}
{"drug1": "6-aminohexanoic acid", "drug2": "tretinoin", "interaction_type": 81, "interaction_text": "6-aminohexanoic acid may increase the thrombogenic activities of tretinoin.", "severity": 2}
{"drug1": "mestranol", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "mestranol may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "QUINESTROL", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of QUINESTROL.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "estriol", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of estriol.", "severity": 2}
{"drug1": "mestranol", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "mestranol may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "dienestrol", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of dienestrol.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "diethylstilbestrol may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "Medroxyprogesterone acetate", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "Medroxyprogesterone acetate may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "diethylstilbestrol may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "thalidomide", "drug2": "estramustine", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of estramustine.", "severity": 2}
{"drug1": "thalidomide", "drug2": "estradiol", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of estradiol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ethinyl estradiol", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of ethinyl estradiol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Drospirenone", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of Drospirenone.", "severity": 2}
{"drug1": "tranexamic acid", "drug2": "ethinyl estradiol", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of ethinyl estradiol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "DESOGESTREL", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of DESOGESTREL.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "diethylstilbestrol may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "diethylstilbestrol may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "dienestrol", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "dienestrol may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "estriol", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "estriol may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "mestranol", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "mestranol may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "tranexamic acid", "drug2": "estradiol", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of estradiol.", "severity": 2}
{"drug1": "diethylstilbestrol", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "diethylstilbestrol may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "estriol", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "estriol may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "estradiol", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "estradiol may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "tranexamic acid", "drug2": "diethylstilbestrol", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of diethylstilbestrol.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Dienogest", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of Dienogest.", "severity": 2}
{"drug1": "dienestrol", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "dienestrol may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "norgestrel", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of norgestrel.", "severity": 2}
{"drug1": "estradiol", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "estradiol may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "dienestrol", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "dienestrol may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "estriol", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "estriol may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "estrone", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of estrone.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "QUINESTROL may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "estradiol", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "estradiol may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "tranexamic acid", "drug2": "Estrone sulfate", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of Estrone sulfate.", "severity": 2}
{"drug1": "thalidomide", "drug2": "diethylstilbestrol", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of diethylstilbestrol.", "severity": 2}
{"drug1": "mestranol", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "mestranol may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "norgestrel", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "norgestrel may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "mestranol", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of mestranol.", "severity": 2}
{"drug1": "ETHYNODIOL DIACETATE", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "ETHYNODIOL DIACETATE may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "estrone", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "estrone may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "estrone", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "estrone may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "Etoricoxib", "interaction_type": 81, "interaction_text": "ethinyl estradiol may increase the thrombogenic activities of Etoricoxib.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "ethinyl estradiol", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of ethinyl estradiol.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "QUINESTROL may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "phytonadione", "drug2": "tretinoin", "interaction_type": 81, "interaction_text": "phytonadione may increase the thrombogenic activities of tretinoin.", "severity": 2}
{"drug1": "estradiol", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "estradiol may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "tibolone", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "tibolone may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Norelgestromin", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of Norelgestromin.", "severity": 2}
{"drug1": "estriol", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "estriol may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "tibolone", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "tibolone may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "Norelgestromin", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "Norelgestromin may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "ethinyl estradiol may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "ETHYNODIOL DIACETATE", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of ETHYNODIOL DIACETATE.", "severity": 2}
{"drug1": "tranexamic acid", "drug2": "estramustine", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of estramustine.", "severity": 2}
{"drug1": "ethinyl estradiol", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "ethinyl estradiol may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "dienestrol", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "dienestrol may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "estriol", "drug2": "etodolac", "interaction_type": 81, "interaction_text": "estriol may increase the thrombogenic activities of etodolac.", "severity": 2}
{"drug1": "dienestrol", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "dienestrol may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "QUINESTROL", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of QUINESTROL.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Estrone sulfate", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of Estrone sulfate.", "severity": 2}
{"drug1": "estradiol", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "estradiol may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "estriol", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of estriol.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "diethylstilbestrol", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of diethylstilbestrol.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "QUINESTROL may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "mestranol", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of mestranol.", "severity": 2}
{"drug1": "tibolone", "drug2": "celecoxib", "interaction_type": 81, "interaction_text": "tibolone may increase the thrombogenic activities of celecoxib.", "severity": 2}
{"drug1": "Dienogest", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "Dienogest may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "tibolone", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "tibolone may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "tranexamic acid", "drug2": "tretinoin", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of tretinoin.", "severity": 2}
{"drug1": "QUINESTROL", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "QUINESTROL may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "estradiol", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of estradiol.", "severity": 2}
{"drug1": "Levonorgestrel", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "Levonorgestrel may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "DESOGESTREL", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "DESOGESTREL may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "thalidomide", "drug2": "tibolone", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of tibolone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Medroxyprogesterone acetate", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of Medroxyprogesterone acetate.", "severity": 2}
{"drug1": "menadione", "drug2": "tretinoin", "interaction_type": 81, "interaction_text": "menadione may increase the thrombogenic activities of tretinoin.", "severity": 2}
{"drug1": "ETONOGESTREL", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "ETONOGESTREL may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "dienestrol", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of dienestrol.", "severity": 2}
{"drug1": "estrone", "drug2": "Lumiracoxib", "interaction_type": 81, "interaction_text": "estrone may increase the thrombogenic activities of Lumiracoxib.", "severity": 2}
{"drug1": "thalidomide", "drug2": "GESTODENE", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of GESTODENE.", "severity": 2}
{"drug1": "estrone", "drug2": "nabumetone", "interaction_type": 81, "interaction_text": "estrone may increase the thrombogenic activities of nabumetone.", "severity": 2}
{"drug1": "thalidomide", "drug2": "Levonorgestrel", "interaction_type": 81, "interaction_text": "thalidomide may increase the thrombogenic activities of Levonorgestrel.", "severity": 2}
{"drug1": "Drospirenone", "drug2": "tranexamic acid", "interaction_type": 81, "interaction_text": "Drospirenone may increase the thrombogenic activities of tranexamic acid.", "severity": 2}
{"drug1": "tranexamic acid", "drug2": "mestranol", "interaction_type": 81, "interaction_text": "tranexamic acid may increase the thrombogenic activities of mestranol.", "severity": 2}
{"drug1": "Lenalidomide", "drug2": "estrone", "interaction_type": 81, "interaction_text": "Lenalidomide may increase the thrombogenic activities of estrone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Asenapine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Asenapine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "calcium lactate", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of calcium lactate.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "Dronedarone may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "digitoxin", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "digitoxin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "halothane", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "halothane may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Paricalcitol", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Paricalcitol.", "severity": 2}
{"drug1": "dopamine", "drug2": "sevoflurane", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of sevoflurane.", "severity": 2}
{"drug1": "astemizole", "drug2": "Delavirdine", "interaction_type": 82, "interaction_text": "astemizole may increase the arrhythmogenic activities of Delavirdine.", "severity": 2}
{"drug1": "digoxin", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "disopyramide", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "disopyramide may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "TRICHLOROETHYLENE", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "TRICHLOROETHYLENE may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "amisulpride", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of amisulpride.", "severity": 2}
{"drug1": "dopamine", "drug2": "enflurane", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of enflurane.", "severity": 2}
{"drug1": "digoxin", "drug2": "ergocalciferol", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of ergocalciferol.", "severity": 2}
{"drug1": "propafenone", "drug2": "SAQUINAVIR", "interaction_type": 82, "interaction_text": "propafenone may increase the arrhythmogenic activities of SAQUINAVIR.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Doxercalciferol", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Doxercalciferol.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "clomipramine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "losartan", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of losartan.", "severity": 2}
{"drug1": "dopamine", "drug2": "halothane", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of halothane.", "severity": 2}
{"drug1": "epinephrine", "drug2": "sevoflurane", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of sevoflurane.", "severity": 2}
{"drug1": "mequitazine", "drug2": "sulpiride", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of sulpiride.", "severity": 2}
{"drug1": "desipramine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "desipramine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "Ibutilide", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "Ibutilide may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "deslanoside", "drug2": "dihydrotachysterol", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of dihydrotachysterol.", "severity": 2}
{"drug1": "digitoxin", "drug2": "calcium lactate", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of calcium lactate.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Pipamperone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Pipamperone.", "severity": 2}
{"drug1": "deslanoside", "drug2": "succinylcholine", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of succinylcholine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Glubionate calcium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Glubionate calcium.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "Tianeptine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Calcifediol", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Calcifediol.", "severity": 2}
{"drug1": "digitoxin", "drug2": "tubocurarine", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of tubocurarine.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "ondansetron", "interaction_type": 82, "interaction_text": "Panobinostat may increase the arrhythmogenic activities of ondansetron.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "DESFLURANE", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of DESFLURANE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "droperidol", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of droperidol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "periciazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of periciazine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "lithium ion", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of lithium ion.", "severity": 2}
{"drug1": "ouabain", "drug2": "Calcium citrate", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Calcium citrate.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "PERINDOPRIL", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of PERINDOPRIL.", "severity": 2}
{"drug1": "mequitazine", "drug2": "risperidone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of risperidone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "MELPERONE", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of MELPERONE.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Mivacurium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Mivacurium.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Mivacurium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Mivacurium.", "severity": 2}
{"drug1": "mequitazine", "drug2": "pentamidine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of pentamidine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "indapamide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of indapamide.", "severity": 2}
{"drug1": "digoxin", "drug2": "decamethonium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of decamethonium.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "mirtazapine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "cyclobenzaprine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "ouabain", "drug2": "decamethonium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of decamethonium.", "severity": 2}
{"drug1": "isoflurane", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "isoflurane may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "mirtazapine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Doxacurium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Doxacurium.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Atracurium besylate", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Atracurium besylate.", "severity": 2}
{"drug1": "mequitazine", "drug2": "perphenazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of perphenazine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Doxercalciferol", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Doxercalciferol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "zotepine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of zotepine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "tiapride", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of tiapride.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "captopril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of captopril.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Doxacurium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Doxacurium.", "severity": 2}
{"drug1": "clomipramine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "clomipramine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Calcium phosphate", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Calcium phosphate.", "severity": 2}
{"drug1": "digoxin", "drug2": "Glubionate calcium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Glubionate calcium.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Rocuronium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Rocuronium.", "severity": 2}
{"drug1": "ouabain", "drug2": "Calcifediol", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Calcifediol.", "severity": 2}
{"drug1": "imipramine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "imipramine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Lurasidone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Lurasidone.", "severity": 2}
{"drug1": "formoterol", "drug2": "methoxyflurane", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of methoxyflurane.", "severity": 2}
{"drug1": "formoterol", "drug2": "enflurane", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of enflurane.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "dopamine", "drug2": "isoflurane", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of isoflurane.", "severity": 2}
{"drug1": "DESFLURANE", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "DESFLURANE may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "cilazapril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of cilazapril.", "severity": 2}
{"drug1": "mequitazine", "drug2": "pimozide", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of pimozide.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "Dothiepin may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Spirapril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of Spirapril.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "TASOSARTAN", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of TASOSARTAN.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Calcium acetate", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Calcium acetate.", "severity": 2}
{"drug1": "ouabain", "drug2": "Paricalcitol", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Paricalcitol.", "severity": 2}
{"drug1": "digitoxin", "drug2": "dihydrotachysterol", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of dihydrotachysterol.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Calcium phosphate", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Calcium phosphate.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "nitrous oxide", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of nitrous oxide.", "severity": 2}
{"drug1": "mequitazine", "drug2": "thioridazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of thioridazine.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "dolasetron", "interaction_type": 82, "interaction_text": "Panobinostat may increase the arrhythmogenic activities of dolasetron.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Calcifediol", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Calcifediol.", "severity": 2}
{"drug1": "formoterol", "drug2": "halothane", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of halothane.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Perospirone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Perospirone.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "furosemide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of furosemide.", "severity": 2}
{"drug1": "ouabain", "drug2": "CALCIUM GLUCONATE", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "dihydrotachysterol", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of dihydrotachysterol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "quetiapine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of quetiapine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "nortriptyline may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "ouabain", "drug2": "tubocurarine", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of tubocurarine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Calcium citrate", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Calcium citrate.", "severity": 2}
{"drug1": "digoxin", "drug2": "PYRANTEL", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of PYRANTEL.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "hydrochlorothiazide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "ouabain", "drug2": "Calcium phosphate", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Calcium phosphate.", "severity": 2}
{"drug1": "thioridazine", "drug2": "chlorpheniramine", "interaction_type": 82, "interaction_text": "thioridazine may increase the arrhythmogenic activities of chlorpheniramine.", "severity": 2}
{"drug1": "ouabain", "drug2": "Vecuronium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Vecuronium.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Doxercalciferol", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Doxercalciferol.", "severity": 2}
{"drug1": "ouabain", "drug2": "METOCURINE", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of METOCURINE.", "severity": 2}
{"drug1": "ouabain", "drug2": "pancuronium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of pancuronium.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Calcium phosphate", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Calcium phosphate.", "severity": 2}
{"drug1": "digoxin", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "amoxapine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "amoxapine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "amitriptyline may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "formoterol", "drug2": "DESFLURANE", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of DESFLURANE.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Enalaprilat", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of Enalaprilat.", "severity": 2}
{"drug1": "mequitazine", "drug2": "loxapine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of loxapine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Remoxipride", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Remoxipride.", "severity": 2}
{"drug1": "mequitazine", "drug2": "SERTINDOLE", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of SERTINDOLE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "nortriptyline may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "ouabain", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Calcium acetate", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Calcium acetate.", "severity": 2}
{"drug1": "ouabain", "drug2": "Doxercalciferol", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Doxercalciferol.", "severity": 2}
{"drug1": "enflurane", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "enflurane may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Cyamemazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Cyamemazine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "ergocalciferol", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of ergocalciferol.", "severity": 2}
{"drug1": "ouabain", "drug2": "Calcium acetate", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Calcium acetate.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Rocuronium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Rocuronium.", "severity": 2}
{"drug1": "mequitazine", "drug2": "chlorprothixene", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of chlorprothixene.", "severity": 2}
{"drug1": "protriptyline", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "protriptyline may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "Dofetilide may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "deslanoside", "drug2": "tubocurarine", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of tubocurarine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "succinylcholine", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of succinylcholine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "MOLINDONE", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of MOLINDONE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Paliperidone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Paliperidone.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Calcium citrate", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Calcium citrate.", "severity": 2}
{"drug1": "epinephrine", "drug2": "enflurane", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of enflurane.", "severity": 2}
{"drug1": "digoxin", "drug2": "Doxercalciferol", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Doxercalciferol.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Aceprometazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Aceprometazine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "trimipramine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "halothane", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of halothane.", "severity": 2}
{"drug1": "digoxin", "drug2": "PIPECURONIUM", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "digoxin", "drug2": "succinylcholine", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of succinylcholine.", "severity": 2}
{"drug1": "digoxin", "drug2": "METOCURINE", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of METOCURINE.", "severity": 2}
{"drug1": "digoxin", "drug2": "pancuronium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of pancuronium.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Calcium citrate", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Calcium citrate.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Doxacurium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Doxacurium.", "severity": 2}
{"drug1": "lidocaine", "drug2": "disopyramide", "interaction_type": 82, "interaction_text": "lidocaine may increase the arrhythmogenic activities of disopyramide.", "severity": 2}
{"drug1": "formoterol", "drug2": "sevoflurane", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of sevoflurane.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "methoxyflurane", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of methoxyflurane.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Fencamfamin", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Fencamfamin.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "trichlormethiazide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of trichlormethiazide.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "cyclobenzaprine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "enflurane", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of enflurane.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "halothane", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of halothane.", "severity": 2}
{"drug1": "dopamine", "drug2": "nitrous oxide", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of nitrous oxide.", "severity": 2}
{"drug1": "deslanoside", "drug2": "decamethonium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of decamethonium.", "severity": 2}
{"drug1": "dopamine", "drug2": "DESFLURANE", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of DESFLURANE.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "Torasemide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of Torasemide.", "severity": 2}
{"drug1": "mequitazine", "drug2": "clozapine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of clozapine.", "severity": 2}
{"drug1": "Ibutilide", "drug2": "lidocaine", "interaction_type": 82, "interaction_text": "Ibutilide may increase the arrhythmogenic activities of lidocaine.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "AZILSARTAN MEDOXOMIL", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of AZILSARTAN MEDOXOMIL.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "rescinnamine", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of rescinnamine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "hydroflumethiazide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Paricalcitol", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Paricalcitol.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "nitrous oxide", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "nitrous oxide may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Calcifediol", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Calcifediol.", "severity": 2}
{"drug1": "quinidine", "drug2": "propafenone", "interaction_type": 82, "interaction_text": "quinidine may increase the arrhythmogenic activities of propafenone.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Atracurium besylate", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Atracurium besylate.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Calcium acetate", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Calcium acetate.", "severity": 2}
{"drug1": "mequitazine", "drug2": "moxifloxacin", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of moxifloxacin.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "imipramine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "imipramine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "deslanoside", "drug2": "CALCIUM GLUCONATE", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "BREXPIPRAZOLE", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of BREXPIPRAZOLE.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "isoflurane", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of isoflurane.", "severity": 2}
{"drug1": "digoxin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "FLUPHENAZINE", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of FLUPHENAZINE.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "lidocaine", "drug2": "SAQUINAVIR", "interaction_type": 82, "interaction_text": "lidocaine may increase the arrhythmogenic activities of SAQUINAVIR.", "severity": 2}
{"drug1": "digitoxin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "chlorthalidone", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of chlorthalidone.", "severity": 2}
{"drug1": "digoxin", "drug2": "Vecuronium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Vecuronium.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "succinylcholine", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of succinylcholine.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Calcium phosphate", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Calcium phosphate.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "nitrous oxide", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of nitrous oxide.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Glubionate calcium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Glubionate calcium.", "severity": 2}
{"drug1": "Panobinostat", "drug2": "granisetron", "interaction_type": 82, "interaction_text": "Panobinostat may increase the arrhythmogenic activities of granisetron.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "calcium lactate", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of calcium lactate.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Aripiprazole", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Aripiprazole.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "propafenone", "interaction_type": 82, "interaction_text": "Dofetilide may increase the arrhythmogenic activities of propafenone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "thiothixene", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of thiothixene.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Thioproperazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Thioproperazine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Pipotiazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Pipotiazine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "CALCIUM CHLORIDE", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Zuclopenthixol", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Zuclopenthixol.", "severity": 2}
{"drug1": "disopyramide", "drug2": "propafenone", "interaction_type": 82, "interaction_text": "disopyramide may increase the arrhythmogenic activities of propafenone.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "decamethonium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of decamethonium.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "isoflurane", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of isoflurane.", "severity": 2}
{"drug1": "doxepin", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "doxepin may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Olmesartan", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of Olmesartan.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "valsartan", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of valsartan.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "ramipril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of ramipril.", "severity": 2}
{"drug1": "deslanoside", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "PROCAINAMIDE may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "methoxyflurane", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of methoxyflurane.", "severity": 2}
{"drug1": "deslanoside", "drug2": "PIPECURONIUM", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Vecuronium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Vecuronium.", "severity": 2}
{"drug1": "mequitazine", "drug2": "mesoridazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of mesoridazine.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "DESFLURANE", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of DESFLURANE.", "severity": 2}
{"drug1": "deslanoside", "drug2": "METOCURINE", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of METOCURINE.", "severity": 2}
{"drug1": "deslanoside", "drug2": "pancuronium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of pancuronium.", "severity": 2}
{"drug1": "ajmaline", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "ajmaline may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "digoxin", "drug2": "Calcifediol", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Calcifediol.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Eprosartan", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of Eprosartan.", "severity": 2}
{"drug1": "amoxapine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "amoxapine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "ouabain", "drug2": "Atracurium besylate", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Atracurium besylate.", "severity": 2}
{"drug1": "mequitazine", "drug2": "prochlorperazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of prochlorperazine.", "severity": 2}
{"drug1": "ouabain", "drug2": "calcium lactate", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of calcium lactate.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "sevoflurane", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of sevoflurane.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "Tianeptine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "quinidine", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "quinidine may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "mequitazine", "drug2": "ACETOPHENAZINE", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of ACETOPHENAZINE.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "enflurane", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of enflurane.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "mirtazapine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "sevoflurane", "interaction_type": 82, "interaction_text": "isoproterenol may increase the arrhythmogenic activities of sevoflurane.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Cariprazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Cariprazine.", "severity": 2}
{"drug1": "dopamine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "cisapride", "drug2": "protriptyline", "interaction_type": 82, "interaction_text": "cisapride may increase the arrhythmogenic activities of protriptyline.", "severity": 2}
{"drug1": "doxepin", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "doxepin may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Ziprasidone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Ziprasidone.", "severity": 2}
{"drug1": "formoterol", "drug2": "TRICHLOROETHYLENE", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "SAQUINAVIR", "interaction_type": 82, "interaction_text": "Dofetilide may increase the arrhythmogenic activities of SAQUINAVIR.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "Dothiepin may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "pancuronium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of pancuronium.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "METOCURINE", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of METOCURINE.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "Vecuronium", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of Vecuronium.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "PIPECURONIUM", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "mequitazine", "drug2": "haloperidol", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of haloperidol.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Atracurium besylate", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Atracurium besylate.", "severity": 2}
{"drug1": "digoxin", "drug2": "Doxacurium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Doxacurium.", "severity": 2}
{"drug1": "ouabain", "drug2": "PYRANTEL", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of PYRANTEL.", "severity": 2}
{"drug1": "ouabain", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "Dothiepin may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Mivacurium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Mivacurium.", "severity": 2}
{"drug1": "protriptyline", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "protriptyline may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "ouabain", "drug2": "CALCIUM CHLORIDE", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "nortriptyline may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "dolasetron", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of dolasetron.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "digoxin", "drug2": "Mivacurium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Mivacurium.", "severity": 2}
{"drug1": "digitoxin", "drug2": "PYRANTEL", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of PYRANTEL.", "severity": 2}
{"drug1": "doxepin", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "doxepin may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Calcium citrate", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Calcium citrate.", "severity": 2}
{"drug1": "flecainide", "drug2": "SAQUINAVIR", "interaction_type": 82, "interaction_text": "flecainide may increase the arrhythmogenic activities of SAQUINAVIR.", "severity": 2}
{"drug1": "trimipramine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "trimipramine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Flupentixol", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Flupentixol.", "severity": 2}
{"drug1": "digoxin", "drug2": "calcium lactate", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of calcium lactate.", "severity": 2}
{"drug1": "ouabain", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "formoterol", "drug2": "nitrous oxide", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of nitrous oxide.", "severity": 2}
{"drug1": "Dronedarone", "drug2": "lidocaine", "interaction_type": 82, "interaction_text": "Dronedarone may increase the arrhythmogenic activities of lidocaine.", "severity": 2}
{"drug1": "amiodarone", "drug2": "Fingolimod", "interaction_type": 82, "interaction_text": "amiodarone may increase the arrhythmogenic activities of Fingolimod.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Levomepromazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Levomepromazine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "clomipramine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "ergocalciferol", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of ergocalciferol.", "severity": 2}
{"drug1": "digitoxin", "drug2": "PIPECURONIUM", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "mequitazine", "drug2": "reserpine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of reserpine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Sacubitril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of Sacubitril.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Telmisartan", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of Telmisartan.", "severity": 2}
{"drug1": "digoxin", "drug2": "dihydrotachysterol", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of dihydrotachysterol.", "severity": 2}
{"drug1": "deslanoside", "drug2": "CALCIUM CHLORIDE", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of CALCIUM CHLORIDE.", "severity": 2}
{"drug1": "digitoxin", "drug2": "METOCURINE", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of METOCURINE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "methoxyflurane", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of methoxyflurane.", "severity": 2}
{"drug1": "amoxapine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "amoxapine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "DESFLURANE", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of DESFLURANE.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "benazepril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of benazepril.", "severity": 2}
{"drug1": "digoxin", "drug2": "Calcium acetate", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Calcium acetate.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "ETHACRYNIC ACID", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "protriptyline", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "protriptyline may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Paricalcitol", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Paricalcitol.", "severity": 2}
{"drug1": "Dofetilide", "drug2": "lidocaine", "interaction_type": 82, "interaction_text": "Dofetilide may increase the arrhythmogenic activities of lidocaine.", "severity": 2}
{"drug1": "epinephrine", "drug2": "isoflurane", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of isoflurane.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "amitriptyline may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "chlorothiazide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of chlorothiazide.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "bumetanide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of bumetanide.", "severity": 2}
{"drug1": "SAQUINAVIR", "drug2": "bepridil", "interaction_type": 82, "interaction_text": "SAQUINAVIR may increase the arrhythmogenic activities of bepridil.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 82, "interaction_text": "norepinephrine may increase the arrhythmogenic activities of TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "trifluoperazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of trifluoperazine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "methyclothiazide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of methyclothiazide.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "QUINETHAZONE", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "polythiazide", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of polythiazide.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "Candesartan cilexetil", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of Candesartan cilexetil.", "severity": 2}
{"drug1": "ouabain", "drug2": "Glubionate calcium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Glubionate calcium.", "severity": 2}
{"drug1": "formoterol", "drug2": "isoflurane", "interaction_type": 82, "interaction_text": "formoterol may increase the arrhythmogenic activities of isoflurane.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "fosinopril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of fosinopril.", "severity": 2}
{"drug1": "digoxin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "TRICHLOROETHYLENE", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of TRICHLOROETHYLENE.", "severity": 2}
{"drug1": "ouabain", "drug2": "PIPECURONIUM", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of PIPECURONIUM.", "severity": 2}
{"drug1": "epinephrine", "drug2": "nitrous oxide", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of nitrous oxide.", "severity": 2}
{"drug1": "mequitazine", "drug2": "ondansetron", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of ondansetron.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Glubionate calcium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Glubionate calcium.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "lisinopril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of lisinopril.", "severity": 2}
{"drug1": "ouabain", "drug2": "Rocuronium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Rocuronium.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "Tianeptine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "ouabain", "drug2": "Mivacurium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Mivacurium.", "severity": 2}
{"drug1": "deslanoside", "drug2": "PYRANTEL", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of PYRANTEL.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Fluspirilene", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Fluspirilene.", "severity": 2}
{"drug1": "ouabain", "drug2": "Doxacurium", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of Doxacurium.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "irbesartan", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of irbesartan.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "quinapril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of quinapril.", "severity": 2}
{"drug1": "digoxin", "drug2": "Atracurium besylate", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Atracurium besylate.", "severity": 2}
{"drug1": "ajmaline", "drug2": "propafenone", "interaction_type": 82, "interaction_text": "ajmaline may increase the arrhythmogenic activities of propafenone.", "severity": 2}
{"drug1": "desipramine", "drug2": "L-thyroxine", "interaction_type": 82, "interaction_text": "desipramine may increase the arrhythmogenic activities of L-thyroxine.", "severity": 2}
{"drug1": "methoxyflurane", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "methoxyflurane may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "PYRANTEL", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of PYRANTEL.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "GALLAMINE TRIETHIODIDE", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of GALLAMINE TRIETHIODIDE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "methadone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of methadone.", "severity": 2}
{"drug1": "mequitazine", "drug2": "olanzapine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of olanzapine.", "severity": 2}
{"drug1": "ouabain", "drug2": "ergocalciferol", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of ergocalciferol.", "severity": 2}
{"drug1": "sevoflurane", "drug2": "Ephedrine", "interaction_type": 82, "interaction_text": "sevoflurane may increase the arrhythmogenic activities of Ephedrine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "amitriptyline may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "digoxin", "drug2": "Rocuronium", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of Rocuronium.", "severity": 2}
{"drug1": "Ibutilide", "drug2": "propafenone", "interaction_type": 82, "interaction_text": "Ibutilide may increase the arrhythmogenic activities of propafenone.", "severity": 2}
{"drug1": "digitoxin", "drug2": "decamethonium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of decamethonium.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Rocuronium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Rocuronium.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "spironolactone", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of spironolactone.", "severity": 2}
{"drug1": "imipramine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "imipramine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "mequitazine", "drug2": "triflupromazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of triflupromazine.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "CALCIUM GLUCONATE", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of CALCIUM GLUCONATE.", "severity": 2}
{"drug1": "mequitazine", "drug2": "erythromycin", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of erythromycin.", "severity": 2}
{"drug1": "PROCAINAMIDE", "drug2": "propafenone", "interaction_type": 82, "interaction_text": "PROCAINAMIDE may increase the arrhythmogenic activities of propafenone.", "severity": 2}
{"drug1": "digitoxin", "drug2": "Vecuronium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of Vecuronium.", "severity": 2}
{"drug1": "epinephrine", "drug2": "halothane", "interaction_type": 82, "interaction_text": "epinephrine may increase the arrhythmogenic activities of halothane.", "severity": 2}
{"drug1": "digitoxin", "drug2": "pancuronium", "interaction_type": 82, "interaction_text": "digitoxin may increase the arrhythmogenic activities of pancuronium.", "severity": 2}
{"drug1": "cisapride", "drug2": "amitriptyline", "interaction_type": 82, "interaction_text": "cisapride may increase the arrhythmogenic activities of amitriptyline.", "severity": 2}
{"drug1": "mequitazine", "drug2": "promazine", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of promazine.", "severity": 2}
{"drug1": "ouabain", "drug2": "dihydrotachysterol", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of dihydrotachysterol.", "severity": 2}
{"drug1": "acetyldigitoxin", "drug2": "tubocurarine", "interaction_type": 82, "interaction_text": "acetyldigitoxin may increase the arrhythmogenic activities of tubocurarine.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "enalapril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of enalapril.", "severity": 2}
{"drug1": "deslanoside", "drug2": "Cisatracurium", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of Cisatracurium.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "MOEXIPRIL", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of MOEXIPRIL.", "severity": 2}
{"drug1": "trimipramine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "trimipramine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "ciprofloxacin", "drug2": "trandolapril", "interaction_type": 82, "interaction_text": "ciprofloxacin may increase the arrhythmogenic activities of trandolapril.", "severity": 2}
{"drug1": "deslanoside", "drug2": "ergocalciferol", "interaction_type": 82, "interaction_text": "deslanoside may increase the arrhythmogenic activities of ergocalciferol.", "severity": 2}
{"drug1": "ouabain", "drug2": "succinylcholine", "interaction_type": 82, "interaction_text": "ouabain may increase the arrhythmogenic activities of succinylcholine.", "severity": 2}
{"drug1": "Ivabradine", "drug2": "metolazone", "interaction_type": 82, "interaction_text": "Ivabradine may increase the arrhythmogenic activities of metolazone.", "severity": 2}
{"drug1": "dopamine", "drug2": "methoxyflurane", "interaction_type": 82, "interaction_text": "dopamine may increase the arrhythmogenic activities of methoxyflurane.", "severity": 2}
{"drug1": "mequitazine", "drug2": "Iloperidone", "interaction_type": 82, "interaction_text": "mequitazine may increase the arrhythmogenic activities of Iloperidone.", "severity": 2}
{"drug1": "desipramine", "drug2": "liothyronine", "interaction_type": 82, "interaction_text": "desipramine may increase the arrhythmogenic activities of liothyronine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "Liotrix", "interaction_type": 82, "interaction_text": "cyclobenzaprine may increase the arrhythmogenic activities of Liotrix.", "severity": 2}
{"drug1": "digoxin", "drug2": "tubocurarine", "interaction_type": 82, "interaction_text": "digoxin may increase the arrhythmogenic activities of tubocurarine.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "dobutamine", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "ritodrine", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "halcinonide", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "betamethasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "paramethasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "equilin", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "medrysone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "equilin", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "equilin", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "hydroflumethiazide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "hydroflumethiazide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "formestane", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "prednisone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of prednisone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "diflorasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of diflorasone.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "dobutamine", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "dobutamine", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "formestane", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "formestane", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "formoterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "dobutamine", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Halobetasol", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Halobetasol.", "severity": 2}
{"drug1": "isoetharine", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "trichlormethiazide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "trichlormethiazide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "ritodrine", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "formoterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "estrone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "medrysone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "epinephrine", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "equilin", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of equilin.", "severity": 2}
{"drug1": "droxidopa", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "flunisolide", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "terbutaline", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "droxidopa", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "medrysone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "budesonide", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "equilin", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "medrysone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Mometasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "prednisone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "paramethasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "formoterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "budesonide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of budesonide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "loteprednol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "formestane", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "formestane", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "paramethasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of paramethasone.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "formestane", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "paramethasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "CORTISONE ACETATE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of CORTISONE ACETATE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "estrone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "formoterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "PREDNICARBATE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of PREDNICARBATE.", "severity": 2}
{"drug1": "loteprednol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "epinephrine", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "droxidopa", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "terbutaline", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "amcinonide", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "dobutamine", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "medrysone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "formoterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "fluocinonide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of fluocinonide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "equilin", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "medrysone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of medrysone.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "prednisone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "formoterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "loteprednol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "medrysone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "polythiazide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "polythiazide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "DESONIDE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of DESONIDE.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "dobutamine", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "budesonide", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "hydrocortisone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of hydrocortisone.", "severity": 2}
{"drug1": "difluprednate", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "triamcinolone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of triamcinolone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "FLUTICASONE PROPIONATE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of FLUTICASONE PROPIONATE.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "equilin", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "amcinonide", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "flurandrenolide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of flurandrenolide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "methylprednisolone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of methylprednisolone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "flunisolide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of flunisolide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "ritodrine", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "betamethasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of betamethasone.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "hydrochlorothiazide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "hydrochlorothiazide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "dobutamine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "estrone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "budesonide", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "dobutamine", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "loteprednol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dobutamine", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "chlorthalidone", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "chlorthalidone may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "ritodrine", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "isoetharine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Mometasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "estrone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of estrone.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "equilin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "halcinonide", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "budesonide", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "estrone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "prednisone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "medrysone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Tixocortol", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Tixocortol.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "amcinonide", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "celiprolol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "medrysone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "formestane", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "BECLOMETHASONE DIPROPIONATE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of BECLOMETHASONE DIPROPIONATE.", "severity": 2}
{"drug1": "flunisolide", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "flumethasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of flumethasone.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "flumethasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "formestane", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Fluticasone furoate", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Fluticasone furoate.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "equilin", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "dexamethasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of dexamethasone.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "RIMEXOLONE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of RIMEXOLONE.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "formoterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "alclometasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of alclometasone.", "severity": 2}
{"drug1": "terbutaline", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "equilin", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "formestane", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "ritodrine", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Estrone sulfate", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Estrone sulfate.", "severity": 2}
{"drug1": "ritodrine", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "BENDROFLUMETHIAZIDE", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "BENDROFLUMETHIAZIDE may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "formoterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Clobetasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Clobetasone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "difluprednate", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "indapamide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "indapamide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "formestane", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "dobutamine", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "ritodrine", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "chlorothiazide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "chlorothiazide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "alclometasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "diflorasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "loteprednol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "dobutamine", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "celiprolol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "amcinonide", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "medrysone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Torasemide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "Torasemide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "formestane", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "difluprednate", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "isoetharine", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "formoterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "isoetharine", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "fludrocortisone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of fludrocortisone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "amcinonide", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "equilin", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "DEFLAZACORT", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of DEFLAZACORT.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "medrysone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "droxidopa", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "prednisone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "FLUOCINOLONE ACETONIDE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of FLUOCINOLONE ACETONIDE.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "medrysone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "loteprednol", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of loteprednol.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "amcinonide", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "flumethasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "droxidopa", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "budesonide", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "dobutamine", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "formoterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "betamethasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "betamethasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "CLOBETASOL PROPIONATE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of CLOBETASOL PROPIONATE.", "severity": 2}
{"drug1": "terbutaline", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "estrone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "metolazone", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "metolazone may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "formoterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "equilin", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "paramethasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "terbutaline", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "medrysone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Dehydroepiandrosterone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Dehydroepiandrosterone.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "halcinonide", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "halcinonide", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "epinephrine", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "epinephrine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "halcinonide", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "droxidopa", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "medrysone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "dobutamine", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "difluprednate", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "difluprednate may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "QUINETHAZONE", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "QUINETHAZONE may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "equilin", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "flunisolide", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "dobutamine", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "budesonide", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "medrysone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "desoximetasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of desoximetasone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "droxidopa", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "ETHACRYNIC ACID", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "ETHACRYNIC ACID may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "paramethasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "prednisone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "flunisolide", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "budesonide", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Fluprednidene", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Fluprednidene.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "loteprednol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "CLOCORTOLONE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of CLOCORTOLONE.", "severity": 2}
{"drug1": "dobutamine", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "dobutamine may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "alclometasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "medrysone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "terbutaline", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "FLUOCORTOLONE", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of FLUOCORTOLONE.", "severity": 2}
{"drug1": "loteprednol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "loteprednol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "diflorasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "amcinonide", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "formestane", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of formestane.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "formoterol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Mometasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "formoterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "alclometasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "formoterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "isoetharine", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "terbutaline", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "bumetanide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "bumetanide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "epinephrine", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "epinephrine may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "diflorasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "equilin", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "flumethasone", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "amcinonide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of amcinonide.", "severity": 2}
{"drug1": "Fluticasone furoate", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Fluticasone furoate may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "furosemide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "furosemide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Salmeterol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Salmeterol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "isoetharine", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "isoetharine may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "estrone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "paramethasone", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "paramethasone may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Levalbuterol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Levalbuterol may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Vilanterol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Vilanterol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Clobetasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Clobetasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Mometasone", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Mometasone.", "severity": 2}
{"drug1": "FLUTICASONE PROPIONATE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "FLUTICASONE PROPIONATE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "amcinonide", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "amcinonide may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "formestane", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "phenylpropanolamine", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "phenylpropanolamine may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "formestane", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "formestane", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "flumethasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "flumethasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "triamcinolone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "triamcinolone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "droxidopa", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "alclometasone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Salbutamol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Salbutamol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "norepinephrine", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "norepinephrine may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "betamethasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "droxidopa", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "droxidopa may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "PROCATEROL", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "PROCATEROL may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "hydrocortisone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "hydrocortisone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Bambuterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "Bambuterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "equilin", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Ciclesonide", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Ciclesonide may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "DESONIDE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "DESONIDE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "formestane", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "diflorasone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "diflorasone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "CLOBETASOL PROPIONATE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "CLOBETASOL PROPIONATE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "equilin", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "equilin", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "equilin may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "medrysone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "medrysone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "betamethasone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "betamethasone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "alclometasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "alclometasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "RIMEXOLONE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "RIMEXOLONE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "Halobetasol", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Halobetasol may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "clenbuterol", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "clenbuterol may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "celiprolol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "terbutaline", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "flunisolide", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "formestane", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "formestane may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "fludrocortisone", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "fludrocortisone may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "PREDNICARBATE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "PREDNICARBATE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "FLUOCINOLONE ACETONIDE", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "FLUOCINOLONE ACETONIDE may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "methyclothiazide", "drug2": "topiramate", "interaction_type": 83, "interaction_text": "methyclothiazide may increase the hypokalemic activities of topiramate.", "severity": 2}
{"drug1": "flurandrenolide", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "flurandrenolide may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "celiprolol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "formoterol", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "formoterol may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "dipivefrin", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "dipivefrin may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "isoproterenol", "drug2": "indapamide", "interaction_type": 83, "interaction_text": "isoproterenol may increase the hypokalemic activities of indapamide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "ritodrine", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "ritodrine may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "methylprednisolone", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "methylprednisolone may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "Ciclesonide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of Ciclesonide.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "FLUOCORTOLONE", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 83, "interaction_text": "FLUOCORTOLONE may increase the hypokalemic activities of BENDROFLUMETHIAZIDE.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Fluprednidene", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Fluprednidene may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "halcinonide", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "halcinonide may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "fluocinonide", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "fluocinonide may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "prednisone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "metaproterenol", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "metaproterenol may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "chlorothiazide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of chlorothiazide.", "severity": 2}
{"drug1": "terbutaline", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "terbutaline may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "prednisone", "drug2": "trichlormethiazide", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of trichlormethiazide.", "severity": 2}
{"drug1": "flunisolide", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "flunisolide may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "dexamethasone", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "dexamethasone may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "PIRBUTEROL", "drug2": "methyclothiazide", "interaction_type": 83, "interaction_text": "PIRBUTEROL may increase the hypokalemic activities of methyclothiazide.", "severity": 2}
{"drug1": "estrone", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "polythiazide", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of polythiazide.", "severity": 2}
{"drug1": "desoximetasone", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "desoximetasone may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "OLODATEROL", "drug2": "chlorthalidone", "interaction_type": 83, "interaction_text": "OLODATEROL may increase the hypokalemic activities of chlorthalidone.", "severity": 2}
{"drug1": "BECLOMETHASONE DIPROPIONATE", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "BECLOMETHASONE DIPROPIONATE may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "Mometasone", "drug2": "QUINETHAZONE", "interaction_type": 83, "interaction_text": "Mometasone may increase the hypokalemic activities of QUINETHAZONE.", "severity": 2}
{"drug1": "Dehydroepiandrosterone", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "Dehydroepiandrosterone may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "celiprolol", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "celiprolol may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "estrone", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "estrone may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "Arformoterol", "drug2": "ETHACRYNIC ACID", "interaction_type": 83, "interaction_text": "Arformoterol may increase the hypokalemic activities of ETHACRYNIC ACID.", "severity": 2}
{"drug1": "DEFLAZACORT", "drug2": "amphotericin b", "interaction_type": 83, "interaction_text": "DEFLAZACORT may increase the hypokalemic activities of amphotericin b.", "severity": 2}
{"drug1": "Estrone sulfate", "drug2": "Torasemide", "interaction_type": 83, "interaction_text": "Estrone sulfate may increase the hypokalemic activities of Torasemide.", "severity": 2}
{"drug1": "budesonide", "drug2": "hydrochlorothiazide", "interaction_type": 83, "interaction_text": "budesonide may increase the hypokalemic activities of hydrochlorothiazide.", "severity": 2}
{"drug1": "CLOCORTOLONE", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "CLOCORTOLONE may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "prednisone", "drug2": "metolazone", "interaction_type": 83, "interaction_text": "prednisone may increase the hypokalemic activities of metolazone.", "severity": 2}
{"drug1": "ARBUTAMINE", "drug2": "furosemide", "interaction_type": 83, "interaction_text": "ARBUTAMINE may increase the hypokalemic activities of furosemide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "difluprednate", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of difluprednate.", "severity": 2}
{"drug1": "CORTISONE ACETATE", "drug2": "hydroflumethiazide", "interaction_type": 83, "interaction_text": "CORTISONE ACETATE may increase the hypokalemic activities of hydroflumethiazide.", "severity": 2}
{"drug1": "Indacaterol", "drug2": "halcinonide", "interaction_type": 83, "interaction_text": "Indacaterol may increase the hypokalemic activities of halcinonide.", "severity": 2}
{"drug1": "Tixocortol", "drug2": "bumetanide", "interaction_type": 83, "interaction_text": "Tixocortol may increase the hypokalemic activities of bumetanide.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "mirtazapine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "amoxapine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "Tianeptine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "amitriptyline may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "protriptyline may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "amoxapine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "clomipramine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "trimipramine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "trimipramine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "Dothiepin may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "cyclobenzaprine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "cyclobenzaprine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "imipramine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "imipramine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "doxepin", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "doxepin may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "nortriptyline may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "protriptyline", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "protriptyline may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "nortriptyline may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "amitriptyline may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "mirtazapine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "Tianeptine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "nortriptyline may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "clomipramine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "clomipramine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "desipramine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "desipramine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "doxepin", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "doxepin may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "clomipramine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "doxepin", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "doxepin may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "mirtazapine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "Dothiepin may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "desipramine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "desipramine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "imipramine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "imipramine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "cyclobenzaprine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "mirtazapine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "trimipramine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "Tianeptine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "clomipramine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "clomipramine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "Tianeptine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "amoxapine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "amoxapine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "protriptyline", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "protriptyline may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "nortriptyline may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "trimipramine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "protriptyline may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "imipramine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "imipramine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "amitriptyline may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "trimipramine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "cyclobenzaprine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "nortriptyline", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "nortriptyline may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "desipramine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "desipramine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "protriptyline", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "protriptyline may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "Dothiepin may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "mirtazapine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "mirtazapine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "amitriptyline may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "clomipramine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "clomipramine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "amitriptyline", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "amitriptyline may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "amoxapine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "doxepin", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "doxepin may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "desipramine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "desipramine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "desipramine", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "desipramine may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "midodrine", "interaction_type": 84, "interaction_text": "Dothiepin may increase the vasopressor activities of midodrine.", "severity": 2}
{"drug1": "cyclobenzaprine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "cyclobenzaprine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "amoxapine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "amoxapine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "Dothiepin", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "Dothiepin may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "trimipramine", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "trimipramine may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "doxepin", "drug2": "phenylephrine", "interaction_type": 84, "interaction_text": "doxepin may increase the vasopressor activities of phenylephrine.", "severity": 2}
{"drug1": "imipramine", "drug2": "metaraminol", "interaction_type": 84, "interaction_text": "imipramine may increase the vasopressor activities of metaraminol.", "severity": 2}
{"drug1": "imipramine", "drug2": "MEPHENTERMINE", "interaction_type": 84, "interaction_text": "imipramine may increase the vasopressor activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Tianeptine", "drug2": "methoxamine", "interaction_type": 84, "interaction_text": "Tianeptine may increase the vasopressor activities of methoxamine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "apraclonidine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of apraclonidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "clonidine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of clonidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "isoxsuprine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of isoxsuprine.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Butylscopolamine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "methoxamine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of methoxamine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "terbutaline", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of terbutaline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "terbutaline", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of terbutaline.", "severity": 2}
{"drug1": "Nabilone", "drug2": "epinephrine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of epinephrine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "benztropine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "PIRBUTEROL", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of PIRBUTEROL.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Lofexidine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of Lofexidine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "phenylpropanolamine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of phenylpropanolamine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "dicyclomine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Arformoterol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of Arformoterol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Nebivolol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ritodrine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of ritodrine.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "isoproterenol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of isoproterenol.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "pancuronium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "phenylpropanolamine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Indacaterol", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of Indacaterol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "metaproterenol", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of metaproterenol.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "tubocurarine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "metaproterenol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of metaproterenol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Nebivolol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of Nebivolol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "tizanidine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of tizanidine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "PROCATEROL", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of PROCATEROL.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "MEPHENTERMINE", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Ephedrine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of Ephedrine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "epinephrine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of epinephrine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "isoproterenol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of isoproterenol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "ritodrine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of ritodrine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "benzphetamine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of benzphetamine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "PROCATEROL", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of PROCATEROL.", "severity": 2}
{"drug1": "Nabilone", "drug2": "MEPHENTERMINE", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "Ephedrine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of Ephedrine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "dipivefrin", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of dipivefrin.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "dopamine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of dopamine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "isoproterenol", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of isoproterenol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "MEPHENTERMINE", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "PROCATEROL", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of PROCATEROL.", "severity": 2}
{"drug1": "Nabilone", "drug2": "labetalol", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of labetalol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "droxidopa", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of droxidopa.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "clenbuterol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of clenbuterol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Ephedrine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of Ephedrine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "MEPHENTERMINE", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "PROCATEROL", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of PROCATEROL.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "methyldopa", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of methyldopa.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "droxidopa", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of droxidopa.", "severity": 2}
{"drug1": "Nabilone", "drug2": "clenbuterol", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of clenbuterol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "brimonidine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of brimonidine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "apraclonidine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of apraclonidine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "trihexyphenidyl may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "nylidrin", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of nylidrin.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "ethopropazine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "quinidine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "quinidine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "norepinephrine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of norepinephrine.", "severity": 2}
{"drug1": "trihexyphenidyl", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "trihexyphenidyl may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "naphazoline", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of naphazoline.", "severity": 2}
{"drug1": "Nabilone", "drug2": "norepinephrine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of norepinephrine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Vilanterol", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of Vilanterol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "ARBUTAMINE", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of ARBUTAMINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "ARBUTAMINE", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of ARBUTAMINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "isoproterenol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of isoproterenol.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "ipratropium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "AMPHETAMINE", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Mirabegron", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of Mirabegron.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "midodrine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of midodrine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "nylidrin", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of nylidrin.", "severity": 2}
{"drug1": "Nabilone", "drug2": "AMPHETAMINE", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of AMPHETAMINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "apraclonidine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of apraclonidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "metaraminol", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of metaraminol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "guanabenz", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of guanabenz.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "methyldopa", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of methyldopa.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "tropicamide may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "ARBUTAMINE", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of ARBUTAMINE.", "severity": 2}
{"drug1": "Butylscopolamine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Butylscopolamine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "metaproterenol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of metaproterenol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "isoproterenol", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of isoproterenol.", "severity": 2}
{"drug1": "pancuronium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "pancuronium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "dobutamine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of dobutamine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "dopamine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of dopamine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "methscopolamine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "phenylpropanolamine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "PIRBUTEROL", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of PIRBUTEROL.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "brimonidine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of brimonidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "isoetharine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of isoetharine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "isoxsuprine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of isoxsuprine.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "hyoscyamine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "propantheline", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "propantheline may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Metixene", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Metixene may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "UMECLIDINIUM may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "oxymetazoline", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of oxymetazoline.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "phenmetrazine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of phenmetrazine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "isoetharine", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of isoetharine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "PROCATEROL", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of PROCATEROL.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Ephedrine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of Ephedrine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "MEPHENTERMINE", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "metaproterenol", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of metaproterenol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "clenbuterol", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of clenbuterol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "HEXOPRENALINE", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "OLODATEROL", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of OLODATEROL.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Mirabegron", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of Mirabegron.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "isoxsuprine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of isoxsuprine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ritodrine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of ritodrine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "formoterol", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of formoterol.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Atracurium besylate may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Salbutamol", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of Salbutamol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "hydroxyamphetamine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "isoetharine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of isoetharine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "phenylephrine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of phenylephrine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "phenylephrine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of phenylephrine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "PROCATEROL", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of PROCATEROL.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Ephedrine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of Ephedrine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "MEPHENTERMINE", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of MEPHENTERMINE.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Tiotropium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "terbutaline", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of terbutaline.", "severity": 2}
{"drug1": "Nabilone", "drug2": "nylidrin", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of nylidrin.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "naphazoline", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of naphazoline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ARBUTAMINE", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of ARBUTAMINE.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "ANISOTROPINE METHYLBROMIDE may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "OLODATEROL", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of OLODATEROL.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "oxyphenonium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "naphazoline", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of naphazoline.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Levalbuterol", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of Levalbuterol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "brimonidine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of brimonidine.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Propiverine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "ANISOTROPINE METHYLBROMIDE", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "ANISOTROPINE METHYLBROMIDE may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "ritodrine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of ritodrine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "droxidopa", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of droxidopa.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "methoxamine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of methoxamine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Arformoterol", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of Arformoterol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Salmeterol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of Salmeterol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Arformoterol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of Arformoterol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "terbutaline", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of terbutaline.", "severity": 2}
{"drug1": "Nabilone", "drug2": "terbutaline", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of terbutaline.", "severity": 2}
{"drug1": "Trospium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Trospium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "celiprolol", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of celiprolol.", "severity": 2}
{"drug1": "oxyphenonium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "oxyphenonium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "metaraminol", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of metaraminol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Lofexidine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of Lofexidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "ARBUTAMINE", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of ARBUTAMINE.", "severity": 2}
{"drug1": "hyoscyamine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "hyoscyamine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "DEXMEDETOMIDINE", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "METHAMPHETAMINE", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "PIRBUTEROL", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of PIRBUTEROL.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "methoxamine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of methoxamine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "OLODATEROL", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of OLODATEROL.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "tolterodine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "pirenzepine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "dipivefrin", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of dipivefrin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "isoetharine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of isoetharine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "DEXMEDETOMIDINE", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "TRIMETHAPHAN may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "OLODATEROL", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of OLODATEROL.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "methyldopa", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of methyldopa.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Salbutamol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of Salbutamol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "phenmetrazine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of phenmetrazine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "Arformoterol", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of Arformoterol.", "severity": 2}
{"drug1": "propantheline", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "propantheline may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "ethopropazine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "ethopropazine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Pentolinium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Vecuronium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "HEXOPRENALINE", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "Nabilone", "drug2": "tetrahydrozoline", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of tetrahydrozoline.", "severity": 2}
{"drug1": "UMECLIDINIUM", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "UMECLIDINIUM may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Vecuronium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Vecuronium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Mirabegron", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of Mirabegron.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "procyclidine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "HEXOPRENALINE", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Methylscopolamine bromide may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "ritodrine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of ritodrine.", "severity": 2}
{"drug1": "Methylscopolamine bromide", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Methylscopolamine bromide may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "phenylpropanolamine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "formoterol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of formoterol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "epinephrine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of epinephrine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "guanabenz", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of guanabenz.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Glycopyrronium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "phenylephrine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of phenylephrine.", "severity": 2}
{"drug1": "biperiden", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "biperiden may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Atracurium besylate", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Atracurium besylate may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "tolterodine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "tolterodine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "nylidrin", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of nylidrin.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "dipivefrin", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of dipivefrin.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "GUANFACINE", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "clenbuterol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of clenbuterol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "phenylpropanolamine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of phenylpropanolamine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "midodrine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of midodrine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "norepinephrine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of norepinephrine.", "severity": 2}
{"drug1": "benztropine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "benztropine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "dobutamine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of dobutamine.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Salbutamol", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of Salbutamol.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "PIPECURONIUM may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "pirenzepine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "pirenzepine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "dipivefrin", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of dipivefrin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "clonidine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of clonidine.", "severity": 2}
{"drug1": "methscopolamine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "methscopolamine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "mecamylamine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "PIPECURONIUM", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "PIPECURONIUM may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "norepinephrine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of norepinephrine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "metaraminol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of metaraminol.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "oxybutynin may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "metaproterenol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of metaproterenol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "acebutolol", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of acebutolol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Salmeterol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of Salmeterol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "DEXMEDETOMIDINE", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of DEXMEDETOMIDINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "PIRBUTEROL", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of PIRBUTEROL.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "oxymetazoline", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of oxymetazoline.", "severity": 2}
{"drug1": "TRIMETHAPHAN", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "TRIMETHAPHAN may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "formoterol", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of formoterol.", "severity": 2}
{"drug1": "Metixene", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Metixene may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Salbutamol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of Salbutamol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "hydroxyamphetamine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of hydroxyamphetamine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "dobutamine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of dobutamine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "benzphetamine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of benzphetamine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "ritodrine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of ritodrine.", "severity": 2}
{"drug1": "ipratropium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "ipratropium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Fesoterodine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "oxymetazoline", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of oxymetazoline.", "severity": 2}
{"drug1": "quinidine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "quinidine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "dobutamine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of dobutamine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "midodrine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of midodrine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "oxymetazoline", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of oxymetazoline.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "guanabenz", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of guanabenz.", "severity": 2}
{"drug1": "biperiden", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "biperiden may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "labetalol", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of labetalol.", "severity": 2}
{"drug1": "Trospium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Trospium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "isoproterenol", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of isoproterenol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "formoterol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of formoterol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "tizanidine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of tizanidine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "acebutolol", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of acebutolol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "formoterol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of formoterol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "epinephrine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of epinephrine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "methoxamine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of methoxamine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "PIRBUTEROL", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of PIRBUTEROL.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "ATROPINE may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "dipivefrin", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of dipivefrin.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "cyclopentolate may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Tiotropium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Tiotropium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "naphazoline", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of naphazoline.", "severity": 2}
{"drug1": "Glycopyrronium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Glycopyrronium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "duloxetine", "drug2": "dobutamine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of dobutamine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "oxymetazoline", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of oxymetazoline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "norepinephrine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of norepinephrine.", "severity": 2}
{"drug1": "Fesoterodine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Fesoterodine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "Ephedrine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of Ephedrine.", "severity": 2}
{"drug1": "cyclopentolate", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "cyclopentolate may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Mirabegron", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of Mirabegron.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "GUANFACINE", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "dobutamine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of dobutamine.", "severity": 2}
{"drug1": "dicyclomine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "dicyclomine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "terbutaline", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of terbutaline.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "methoxamine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of methoxamine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "epinephrine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of epinephrine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "phenylephrine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of phenylephrine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "isoetharine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of isoetharine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "tubocurarine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "tubocurarine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "nylidrin", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of nylidrin.", "severity": 2}
{"drug1": "tropicamide", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "tropicamide may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "epinephrine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of epinephrine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "celiprolol", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of celiprolol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "GUANFACINE", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of GUANFACINE.", "severity": 2}
{"drug1": "procyclidine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "procyclidine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "clenbuterol", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of clenbuterol.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "metaproterenol", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of metaproterenol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "isoxsuprine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of isoxsuprine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "phenylephrine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of phenylephrine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "epinastine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of epinastine.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "clonidine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of clonidine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Arformoterol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of Arformoterol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "metaraminol", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of metaraminol.", "severity": 2}
{"drug1": "duloxetine", "drug2": "epinastine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of epinastine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "phenylpropanolamine", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of phenylpropanolamine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "norepinephrine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of norepinephrine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "metaraminol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of metaraminol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "metaraminol", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of metaraminol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "Salbutamol", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of Salbutamol.", "severity": 2}
{"drug1": "ATROPINE", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "ATROPINE may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Propiverine", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Propiverine may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "methoxamine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of methoxamine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "METHAMPHETAMINE", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of METHAMPHETAMINE.", "severity": 2}
{"drug1": "duloxetine", "drug2": "oxymetazoline", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of oxymetazoline.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "droxidopa", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of droxidopa.", "severity": 2}
{"drug1": "duloxetine", "drug2": "Salmeterol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of Salmeterol.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Aclidinium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Atomoxetine", "drug2": "Bambuterol", "interaction_type": 85, "interaction_text": "Atomoxetine may increase the tachycardic activities of Bambuterol.", "severity": 2}
{"drug1": "Nabilone", "drug2": "isoxsuprine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of isoxsuprine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "nylidrin", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of nylidrin.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "Lofexidine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of Lofexidine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "midodrine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of midodrine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "clenbuterol", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of clenbuterol.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "guanabenz", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of guanabenz.", "severity": 2}
{"drug1": "mecamylamine", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "mecamylamine may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Levomilnacipran", "drug2": "epinastine", "interaction_type": 85, "interaction_text": "Levomilnacipran may increase the tachycardic activities of epinastine.", "severity": 2}
{"drug1": "Pentolinium", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "Pentolinium may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "oxybutynin", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "oxybutynin may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Nabilone", "drug2": "midodrine", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of midodrine.", "severity": 2}
{"drug1": "Nabilone", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 85, "interaction_text": "Nabilone may increase the tachycardic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Aclidinium", "drug2": "Nabilone", "interaction_type": 85, "interaction_text": "Aclidinium may increase the tachycardic activities of Nabilone.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "midodrine", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of midodrine.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "PSEUDOEPHEDRINE", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of PSEUDOEPHEDRINE.", "severity": 2}
{"drug1": "Dronabinol", "drug2": "tetrahydrozoline", "interaction_type": 85, "interaction_text": "Dronabinol may increase the tachycardic activities of tetrahydrozoline.", "severity": 2}
{"drug1": "duloxetine", "drug2": "phenylephrine", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of phenylephrine.", "severity": 2}
{"drug1": "duloxetine", "drug2": "HEXOPRENALINE", "interaction_type": 85, "interaction_text": "duloxetine may increase the tachycardic activities of HEXOPRENALINE.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "epinastine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of epinastine.", "severity": 2}
{"drug1": "venlafaxine", "drug2": "tizanidine", "interaction_type": 85, "interaction_text": "venlafaxine may increase the tachycardic activities of tizanidine.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "droxidopa", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of droxidopa.", "severity": 2}
{"drug1": "GALLAMINE TRIETHIODIDE", "drug2": "Dronabinol", "interaction_type": 85, "interaction_text": "GALLAMINE TRIETHIODIDE may increase the tachycardic activities of Dronabinol.", "severity": 2}
{"drug1": "Milnacipran", "drug2": "OLODATEROL", "interaction_type": 85, "interaction_text": "Milnacipran may increase the tachycardic activities of OLODATEROL.", "severity": 2}
{"drug1": "allopurinol", "drug2": "lisinopril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to lisinopril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "methyclothiazide", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to methyclothiazide is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "ramipril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to ramipril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "chlorthalidone", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to chlorthalidone is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "quinapril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to quinapril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "chlorothiazide", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to chlorothiazide is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "trandolapril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to trandolapril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "rescinnamine", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to rescinnamine is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Spirapril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to Spirapril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "QUINETHAZONE", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to QUINETHAZONE is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "polythiazide", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to polythiazide is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "cilazapril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to cilazapril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "trichlormethiazide", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to trichlormethiazide is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "amoxicillin", "drug2": "allopurinol", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to allopurinol is increased when it is combined with amoxicillin.", "severity": 2}
{"drug1": "allopurinol", "drug2": "enalapril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to enalapril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "hydrochlorothiazide", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to hydrochlorothiazide is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "indapamide", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to indapamide is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "BENDROFLUMETHIAZIDE", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to BENDROFLUMETHIAZIDE is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "hydroflumethiazide", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to hydroflumethiazide is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "metolazone", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to metolazone is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "captopril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to captopril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "benazepril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to benazepril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "fosinopril", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to fosinopril is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "Enalaprilat", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to Enalaprilat is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "allopurinol", "drug2": "PERINDOPRIL", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to PERINDOPRIL is increased when it is combined with allopurinol.", "severity": 2}
{"drug1": "ampicillin", "drug2": "allopurinol", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to allopurinol is increased when it is combined with ampicillin.", "severity": 2}
{"drug1": "allopurinol", "drug2": "MOEXIPRIL", "interaction_type": 86, "interaction_text": "The risk of a hypersensitivity reaction to MOEXIPRIL is increased when it is combined with allopurinol.", "severity": 2}